{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:32:37Z","timestamp":1792031557719,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1062721"],"award-info":[{"award-number":["APP1062721"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Group-of-Eight Australia (Go8)\/German Academic Exchange Service (DAAD) Joint Research-Cooperation Scheme"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Postgraduate Award"},{"name":"Monash Graduate Scholarship"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.phrs.2016.12.015","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T23:46:21Z","timestamp":1481672781000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Anakinra reduces blood pressure and renal fibrosis in one kidney\/DOCA\/salt-induced hypertension"],"prefix":"10.1016","volume":"116","author":[{"given":"Yeong Hann","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini M.","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Diep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Ferens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaye","family":"Chin-Dusting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara K.","family":"Kemp-Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrishan S.","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Hewitson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eicke","family":"Latz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Mansell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Sobey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant R.","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2016.12.015_bib0005","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0022-2143(97)90178-5","article-title":"Increased serum levels of interleukin-1\u03b2 in the systemic circulation of patients with essential hypertension: additional risk factor for atherogenesis in hypertensive patients?","volume":"129","author":"Dalekos","year":"1997","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.phrs.2016.12.015_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/619704","article-title":"Proinflammation and hypertension. A population-based study","volume":"2008","author":"Mauno","year":"2008","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phrs.2016.12.015_bib0015","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2016.12.015_bib0020","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/bph.13230","article-title":"Inflammasome activity is essential for one kidney\/deoxycorticosterone acetate\/salt-induced hypertension in mice","volume":"173","author":"Krishnan","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0025","first-page":"6","article-title":"Renin-dependent hypertension in mice requires the NLRP3- inflammasome","volume":"3","author":"Wang","year":"2013","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2016.12.015_bib0030","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2567.2010.03283.x","article-title":"Regulation of inflammasome activity","volume":"130","author":"Guarda","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.phrs.2016.12.015_bib0035","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1161\/HYPERTENSIONAHA.112.201251","article-title":"Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone\/salt-treated mice","volume":"60","author":"Chan","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2016.12.015_bib0040","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.yrtph.2011.01.014","article-title":"Integration of efficacy, pharmacokinetic and safety assessment of interleukin-1 receptor antagonist in a preclinical model of arthritis","volume":"59","author":"Zuurmond","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0045","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1161\/CIRCULATIONAHA.107.740233","article-title":"a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction","volume":"117","author":"Abbate","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2016.12.015_bib0050","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1001\/archopht.123.7.957","article-title":"Suppression of immune-mediated ocular inflammation in mice by interleukin 1 receptor antagonist administration","volume":"123","author":"Lim","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2199-8-113","article-title":"Relative quantification of mRNA: Comparison of methods currently used for real-time PCR data analysis","volume":"8","author":"Cikos","year":"2007","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0060","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1440-1681.2011.05482.x","article-title":"Renal inflammation, autoimmunity and salt-sensitive hypertension","volume":"39","author":"Rodr\u00edguez-Iturbe","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1152\/advan.00063.2013","article-title":"The immune system in hypertension","volume":"38","author":"Trott","year":"2014","journal-title":"Adv. Physiol. Educ."},{"key":"10.1016\/j.phrs.2016.12.015_bib0070","doi-asserted-by":"crossref","DOI":"10.20452\/pamw.3275","article-title":"Malignant hypertension \u2013 new aspects of an old clinical entity","author":"Januszewicz","year":"2015","journal-title":"Polish Arch. Intern. Med."},{"key":"10.1016\/j.phrs.2016.12.015_bib0075","series-title":"Assessment Report: Kineret","year":"2013"},{"key":"10.1016\/j.phrs.2016.12.015_bib0080","doi-asserted-by":"crossref","first-page":"b1665","DOI":"10.1136\/bmj.b1665","article-title":"Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies","volume":"338","author":"Law","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2016.12.015_bib0085","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/HYPERTENSIONAHA.114.04006","article-title":"Preventing autoimmunity protects against the development of hypertension and renal injury","volume":"64","author":"Mathis","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2016.12.015_bib0090","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.2174\/138161211798764753","article-title":"Inflammation in hypertension: current therapeutic approaches","volume":"17","author":"Androulakis","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.phrs.2016.12.015_bib0095","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/hr.2013.99","article-title":"Renal inflammatory markers during the onset of hypertension in spontaneously hypertensive rats","volume":"37","author":"Heijnen","year":"2014","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.phrs.2016.12.015_bib0100","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1159\/000082313","article-title":"Evolution of renal interstitial inflammation and NF-\u03baB activation in spontaneously hypertensive rats","volume":"24","author":"Rodr\u00edguez-Iturbe","year":"2004","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0105","doi-asserted-by":"crossref","first-page":"25900","DOI":"10.1074\/jbc.M707692200","article-title":"Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT\/IkappaB kinase alpha pathway targeting activator protein-1","volume":"283","author":"Cahill","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.12.015_bib0110","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2249.1993.tb08203.x","article-title":"Interaction of IL-1 beta, IL-6 and tumour necrosis factor-alpha (TNF-alpha) in human T cells activated by murine antigens","volume":"93","author":"Panzer","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0115","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1161\/HYPERTENSIONAHA.115.05779","article-title":"Obligatory role for b cells in the development of angiotensin II\u2013dependent hypertension","volume":"66","author":"Chan","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2016.12.015_bib0120","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20070657","article-title":"Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction","volume":"204","author":"Guzik","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2016.12.015_bib0125","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1097\/01.CCM.0000053516.15727.E5","article-title":"Interleukin-1 beta rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism","volume":"31","author":"Loughrey","year":"2003","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.phrs.2016.12.015_bib0130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1124\/jpet.105.088435","article-title":"Increased superoxide anion production by interleukin-1 beta impairs nitric oxide-mediated relaxation in resistance arteries","volume":"316","author":"Jim\u00e9nez-Altay\u00f3","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2016.12.015_bib0135","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.vph.2007.05.007","article-title":"Interleukin 1-beta (lL-1\u03b2) enhances contractile responses in endothelium-denuded aorta from hypertensive, but not normotensive rats","volume":"47","author":"Dorrance","year":"2007","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0140","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.ph.57.030195.001403","article-title":"Progression of renal disease and renal hypertrophy","volume":"57","author":"Hostetter","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0145","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00421-008-0755-1","article-title":"Interleukin-1 receptor antagonist restores homeostatic function and limits multiorgan damage in heatstroke","volume":"103","author":"Shen","year":"2008","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.phrs.2016.12.015_bib0150","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0272-6386(97)90495-9","article-title":"Interleukin-1 receptor antagonist modulates the progression of a spontaneously occurring IgA nephropathy in mice","volume":"30","author":"Chen","year":"1997","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.phrs.2016.12.015_bib0155","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ki.1993.70","article-title":"Suppression of experimental crescentic glomerulonephritis by the interleukin-1 receptor antagonist","volume":"43","author":"Lan","year":"1993","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.12.015_bib0160","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1369\/0022155414545787","article-title":"Picrosirius red staining: a useful tool to appraise collagen networks in normal and pathological tissues","volume":"62","author":"Lattouf","year":"2014","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.phrs.2016.12.015_bib0165","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1242\/dmm.012062","article-title":"Diverse functions of matrix metalloproteinases during fibrosis","volume":"7","author":"Giannandrea","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.phrs.2016.12.015_bib0170","first-page":"211","article-title":"Progression of chronic renal disease in humans is associated with the deposition of basement membrane components and decorin in the interstitial extracellular matrix","volume":"44","author":"Vleming","year":"1995","journal-title":"Clin. Nephrol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816313299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816313299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T05:07:22Z","timestamp":1718946442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816313299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":34,"alternative-id":["S1043661816313299"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.015","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anakinra reduces blood pressure and renal fibrosis in one kidney\/DOCA\/salt-induced hypertension","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}