{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:24:58Z","timestamp":1790263498483,"version":"4.1.0"},"reference-count":191,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Victorian Government\u2019s Operational Infrastructure Support Program"},{"name":"J & E Borrowman Research Trust"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.phrs.2016.12.016","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T18:16:38Z","timestamp":1481739398000},"page":"45-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"special_numbering":"C","title":["Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications"],"prefix":"10.1016","volume":"116","author":[{"given":"Cheng Xue","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle","family":"Sleaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J.","family":"Davidoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles J.","family":"De Blasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne M.","family":"Delbridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Chatham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca H.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0005","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nchembio.338","article-title":"Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc","volume":"6","author":"Teo","year":"2010","journal-title":"Nat. Chem. Biol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0010","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00125-014-3171-6","article-title":"Molecular mechanisms of diabetic cardiomyopathy","volume":"57","author":"Bugger","year":"2014","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.pharmthera.2014.01.003","article-title":"Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways","volume":"142","author":"Huynh","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0020","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","article-title":"New type of cardiomyopathy associated with diabetic glomerulosclerosis","volume":"30","author":"Rubler","year":"1972","journal-title":"Am. J. Cardiol."},{"issue":"6 Pt 2","key":"10.1016\/j.phrs.2016.12.016_bib0025","first-page":"H2876","article-title":"High extracellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner","volume":"273","author":"Ren","year":"1997","journal-title":"Am. J. Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0030","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0035","doi-asserted-by":"crossref","first-page":"H1489","DOI":"10.1152\/ajpheart.00278.2006","article-title":"Role of changes in cardiac metabolism in development of diabetic cardiomyopathy","volume":"291","author":"An","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.016_bib0040","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1006\/jmcc.2002.2084","article-title":"Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes","volume":"34","author":"Petrova","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1-2","key":"10.1016\/j.phrs.2016.12.016_bib0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/B:MCBI.0000038231.68078.4b","article-title":"Diabetic cardiomyocyte dysfunction and myocyte insulin resistance: role of glucose-induced PKC activity","volume":"262","author":"Davidoff","year":"2004","journal-title":"Mol. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0050","doi-asserted-by":"crossref","first-page":"C456","DOI":"10.1152\/ajpcell.00124.2010","article-title":"Muscle-specific overexpression of NCOATGK, splice variant of O-GlcNAcase, induces skeletal muscle atrophy","volume":"300","author":"Huang","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"11","key":"10.1016\/j.phrs.2016.12.016_bib0055","doi-asserted-by":"crossref","first-page":"7097","DOI":"10.1074\/jbc.M114.617779","article-title":"Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis","volume":"290","author":"Keembiyehetty","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"7139","key":"10.1016\/j.phrs.2016.12.016_bib0060","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature05815","article-title":"Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins","volume":"446","author":"Hart","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0065","doi-asserted-by":"crossref","first-page":"H13","DOI":"10.1152\/ajpheart.01056.2008","article-title":"Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system","volume":"296","author":"Laczy","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0070","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1161\/CIRCRESAHA.110.224675","article-title":"O-GlcNAc signaling in the cardiovascular system","volume":"107","author":"Ngoh","year":"2010","journal-title":"Circ. Res."},{"issue":"1-2","key":"10.1016\/j.phrs.2016.12.016_bib0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mce.2009.09.022","article-title":"Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes","volume":"318","author":"Teo","year":"2010","journal-title":"Mol. Cell Endocrinol."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.016_bib0080","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1016\/S0021-9258(19)67706-9","article-title":"Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance","volume":"266","author":"Marshall","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0085","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1152\/japplphysiol.00865.2005","article-title":"Bastide B: O-GlcNAc level variations are associated with the development of skeletal muscle atrophy","volume":"100","author":"Cieniewski-Bernard","year":"2006","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"17","key":"10.1016\/j.phrs.2016.12.016_bib0090","doi-asserted-by":"crossref","first-page":"14764","DOI":"10.1074\/jbc.M201056200","article-title":"Kinetic characterization of human glutamine-fructose-6-phosphate amidotransferase I: potent feedback inhibition by glucosamine 6-phosphate","volume":"277","author":"Broschat","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"5\u20136","key":"10.1016\/j.phrs.2016.12.016_bib0095","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/pmic.201400326","article-title":"Detection and identification of O-GlcNAcylated proteins by proteomic approaches","volume":"15","author":"Vercoutter-Edouart","year":"2015","journal-title":"Proteomics"},{"issue":"10","key":"10.1016\/j.phrs.2016.12.016_bib0100","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.tibs.2010.04.005","article-title":"O-GlcNAc signaling: a metabolic link between diabetes and cancer?","volume":"35","author":"Slawson","year":"2010","journal-title":"Trends Biochem. Sci."},{"issue":"Part 1","key":"10.1016\/j.phrs.2016.12.016_bib0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1242\/jcs.053678","article-title":"The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways","volume":"123","author":"Zeidan","year":"2010","journal-title":"J. Cell Sci."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2016.12.016_bib0110","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1440-1681.2006.04343.x","article-title":"Convergence of glucose- and fatty acid-induced abnormal myocardial excitation-contraction coupling and insulin signalling","volume":"33","author":"Davidoff","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0115","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1210\/endo.141.6.7566","article-title":"Hexosamines and nutrient sensing","volume":"141","author":"Perspective","year":"2000","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1056-8727(01)00188-X","article-title":"Hexosamines as mediators of nutrient sensing and regulation in diabetes","volume":"16","author":"McClain","year":"2002","journal-title":"J. Diabetes Complications"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0125","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s000180300017","article-title":"A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance","volume":"60","author":"Wells","year":"2003","journal-title":"Cell Mol. Life Sci."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2016.12.016_bib0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbagen.2004.03.016","article-title":"O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress","volume":"1673","author":"Zachara","year":"2004","journal-title":"Biochim. Biophys. Acta."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0135","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1124\/jpet.108.143263","article-title":"New insights into metabolic signaling and cell survival: the role of beta-O-linkage of N-acetylglucosamine","volume":"327","author":"Ngoh","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2016.12.016_bib0140","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev-nutr-071812-161240","article-title":"O-GlcNAc cycling: a link between metabolism and chronic disease","volume":"33","author":"Bond","year":"2013","journal-title":"Ann. Rev. Nutr."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0145","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3390\/molecules16031987","article-title":"Chemical arsenal for the study of O-GlcNAc","volume":"16","author":"Kim","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.phrs.2016.12.016_bib0150","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev-biochem-060608-102511","article-title":"Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease","volume":"80","author":"Hart","year":"2011","journal-title":"Ann. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0155","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pharmthera.2013.11.005","article-title":"O-GlcNAc and the cardiovascular system","volume":"142","author":"Dassanayaka","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0160","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1016\/S0021-9258(17)43295-9","article-title":"Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc","volume":"259","author":"Torres","year":"1984","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.phrs.2016.12.016_bib0165","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1073\/pnas.1424017112","article-title":"Diabetes-associated dysregulation of O-GlcNAcylation in rat cardiac mitochondria","volume":"112","author":"Banerjee","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0170","doi-asserted-by":"crossref","first-page":"e18959","DOI":"10.1371\/journal.pone.0018959","article-title":"O-GlcNAc-specific antibody CTD110.6 cross-reacts with N-GlcNAc2-modified proteins induced under glucose deprivation","volume":"6","author":"Isono","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0175","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/abio.1996.0047","article-title":"Selective detection and site-analysis of O-GlcNAc-modified glycopeptides by beta-elimination and tandem electrospray mass spectrometry","volume":"234","author":"Greis","year":"1996","journal-title":"Anal. Biochem."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.016_bib0180","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1074\/mcp.M200048-MCP200","article-title":"Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications","volume":"1","author":"Wells","year":"2002","journal-title":"Mol. Cell Proteomics"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0185","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1074\/mcp.T500040-MCP200","article-title":"O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry","volume":"5","author":"Vosseller","year":"2006","journal-title":"Mol. Cell Proteomics"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0190","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1074\/mcp.M900268-MCP200","article-title":"Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical\/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry","volume":"9","author":"Wang","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"issue":"19","key":"10.1016\/j.phrs.2016.12.016_bib0195","doi-asserted-by":"crossref","first-page":"7280","DOI":"10.1073\/pnas.1200425109","article-title":"Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets","volume":"109","author":"Alfaro","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0200","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.yjmcc.2011.08.009","article-title":"Protein O-linked beta-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function","volume":"52","author":"Darley-Usmar","year":"2012","journal-title":"J. Mol. Cell Cardiol"},{"issue":"12","key":"10.1016\/j.phrs.2016.12.016_bib0205","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.bbapap.2006.10.003","article-title":"The utility of ETD mass spectrometry in proteomic analysis","volume":"1764","author":"Mikesh","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0210","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1210\/endo.138.6.5172","article-title":"Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues","volume":"138","author":"Virkamaki","year":"1997","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0215","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.yjmcc.2005.11.003","article-title":"Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemia","volume":"40","author":"Liu","year":"2006","journal-title":"J. Mol. Cell Cardiol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0220","doi-asserted-by":"crossref","first-page":"e18417","DOI":"10.1371\/journal.pone.0018417","article-title":"Acute regulation of cardiac metabolism by the hexosamine biosynthesis pathway and protein O-GlcNAcylation","volume":"6","author":"Laczy","year":"2011","journal-title":"PLoS One"},{"issue":"34","key":"10.1016\/j.phrs.2016.12.016_bib0225","doi-asserted-by":"crossref","first-page":"35313","DOI":"10.1074\/jbc.M404133200","article-title":"Dynamic actions of glucose and glucosamine on hexosamine biosynthesis in isolated adipocytes: differential effects on glucosamine 6-phosphate, UDP-N-acetylglucosamine, and ATP levels","volume":"279","author":"Marshall","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0230","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/geno.1999.5785","article-title":"cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse","volume":"57","author":"Oki","year":"1999","journal-title":"Genomics"},{"issue":"11","key":"10.1016\/j.phrs.2016.12.016_bib0235","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.2337\/diabetes.50.11.2419","article-title":"A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle","volume":"50","author":"DeHaven","year":"2001","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.phrs.2016.12.016_bib0240","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s100380170022","article-title":"Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle","volume":"46","author":"Niimi","year":"2001","journal-title":"J. Hum. Genet."},{"issue":"7","key":"10.1016\/j.phrs.2016.12.016_bib0245","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1210\/endo.136.7.7789306","article-title":"Regulation of glutamine:fructose-6-phosphate amidotransferase gene transcription by epidermal growth factor and glucose","volume":"136","author":"Paterson","year":"1995","journal-title":"Endocrinology"},{"issue":"29","key":"10.1016\/j.phrs.2016.12.016_bib0250","doi-asserted-by":"crossref","first-page":"21981","DOI":"10.1074\/jbc.M001049200","article-title":"Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity","volume":"275","author":"Chang","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"29","key":"10.1016\/j.phrs.2016.12.016_bib0255","doi-asserted-by":"crossref","first-page":"29988","DOI":"10.1074\/jbc.M401547200","article-title":"Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity","volume":"279","author":"Hu","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0260","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1210\/endo.141.6.7532","article-title":"Hexosamines stimulate leptin production in transgenic mice","volume":"141","author":"McClain","year":"2000","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0265","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1210\/en.2003-0812","article-title":"Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance","volume":"145","author":"Hazel","year":"2004","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0270","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/S0021-9258(19)39838-2","article-title":"Enzymatic addition of O-GlcNAc to nuclear and cytoplasmic proteins: identification of a uridine diphospho-N-acetylglucosamine:peptide beta-N-acetylglucosaminyltransferase","volume":"265","author":"Haltiwanger","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.phrs.2016.12.016_bib0275","doi-asserted-by":"crossref","first-page":"9005","DOI":"10.1016\/S0021-9258(19)50380-5","article-title":"Glycosylation of nuclear and cytoplasmic proteins: purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase","volume":"267","author":"Haltiwanger","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.phrs.2016.12.016_bib0280","doi-asserted-by":"crossref","first-page":"9308","DOI":"10.1074\/jbc.272.14.9308","article-title":"Dynamic glycosylation of nuclear and cytosolic proteins: cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats","volume":"272","author":"Kreppel","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"15","key":"10.1016\/j.phrs.2016.12.016_bib0285","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1074\/jbc.275.15.10983","article-title":"Functional expression of O-linked GlcNAc transferase: domain structure and substrate specificity","volume":"275","author":"Lubas","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0290","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cell.2010.12.030","article-title":"O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1","volume":"144","author":"Capotosti","year":"2011","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.phrs.2016.12.016_bib0295","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1073\/pnas.1013822108","article-title":"Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway","volume":"108","author":"Daou","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"14","key":"10.1016\/j.phrs.2016.12.016_bib0300","doi-asserted-by":"crossref","first-page":"9316","DOI":"10.1074\/jbc.272.14.9316","article-title":"O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats","volume":"272","author":"Lubas","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.phrs.2016.12.016_bib0305","doi-asserted-by":"crossref","first-page":"9838","DOI":"10.1074\/jbc.M010420200","article-title":"Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain","volume":"276","author":"Gao","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"45","key":"10.1016\/j.phrs.2016.12.016_bib0310","doi-asserted-by":"crossref","first-page":"32015","DOI":"10.1074\/jbc.274.45.32015","article-title":"Regulation of a cytosolic and nuclear O-GlcNAc transferase: role of the tetratricopeptide repeats","volume":"274","author":"Kreppel","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"7331","key":"10.1016\/j.phrs.2016.12.016_bib0315","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature09638","article-title":"Structure of human O-GlcNAc transferase and its complex with a peptide substrate","volume":"469","author":"Lazarus","year":"2011","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.phrs.2016.12.016_bib0320","doi-asserted-by":"crossref","first-page":"13009","DOI":"10.1074\/jbc.M801222200","article-title":"AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation","volume":"283","author":"Cheung","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"49","key":"10.1016\/j.phrs.2016.12.016_bib0325","doi-asserted-by":"crossref","first-page":"33935","DOI":"10.1074\/jbc.M806199200","article-title":"O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins","volume":"283","author":"Cheung","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0330","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbagen.2009.07.018","article-title":"O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress","volume":"1800","author":"Butkinaree","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0335","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.cardiores.2006.07.018","article-title":"Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system","volume":"73","author":"Fulop","year":"2007","journal-title":"Cardiovasc. Res."},{"issue":"Part 1","key":"10.1016\/j.phrs.2016.12.016_bib0340","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/bj3340283","article-title":"Permanent exposure of mucin-secreting HT-29 cells to benzyl-N-acetyl-alpha-D-galactosaminide induces abnormal O-glycosylation of mucins and inhibits constitutive and stimulated MUC5AC secretion","volume":"334","author":"Hennebicq-Reig","year":"1998","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0345","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1042\/BST20150189","article-title":"O-GlcNAc transferase inhibitors: current tools and future challenges","volume":"44","author":"Trapannone","year":"2016","journal-title":"Biochem. Soc. Trans."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0350","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0006-291X(02)00200-0","article-title":"Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase","volume":"293","author":"Konrad","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0355","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1073\/pnas.97.6.2820","article-title":"Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death","volume":"97","author":"Liu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"42","key":"10.1016\/j.phrs.2016.12.016_bib0360","doi-asserted-by":"crossref","first-page":"14588","DOI":"10.1021\/ja0555217","article-title":"Discovery of O-GlcNAc transferase inhibitors","volume":"127","author":"Gross","year":"2005","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0365","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nchembio.711","article-title":"A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase","volume":"8","author":"Jiang","year":"2012","journal-title":"Nat. Chem. Biol."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.016_bib0370","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1039\/C2CS35412H","article-title":"Chemical approaches to study O-GlcNAcylation","volume":"42","author":"Banerjee","year":"2013","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0375","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.yjmcc.2008.04.009","article-title":"Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition","volume":"45","author":"Ngoh","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0380","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/stem.1325","article-title":"Protein O-GlcNAcylation is a novel cytoprotective signal in cardiac stem cells","volume":"31","author":"Zafir","year":"2013","journal-title":"Stem Cells"},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0385","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nchembio.520","article-title":"Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells","volume":"7","author":"Gloster","year":"2011","journal-title":"Nat. Chem. Biol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0390","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1021\/acschembio.5b00004","article-title":"A small molecule that inhibits OGT activity in cells","volume":"10","author":"Ortiz-Meoz","year":"2015","journal-title":"ACS Chem. Biol."},{"issue":"16","key":"10.1016\/j.phrs.2016.12.016_bib0395","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1073\/pnas.152346899","article-title":"Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia","volume":"99","author":"McClain","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"41","key":"10.1016\/j.phrs.2016.12.016_bib0400","doi-asserted-by":"crossref","first-page":"17797","DOI":"10.1073\/pnas.1001907107","article-title":"O-linked beta-N-acetylglucosamine transferase is indispensable in the failing heart","volume":"107","author":"Watson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0405","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1006\/bbrc.2001.4815","article-title":"Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase","volume":"283","author":"Comtesse","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5\u20136","key":"10.1016\/j.phrs.2016.12.016_bib0410","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.cbpa.2012.10.021","article-title":"O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation","volume":"16","author":"Vocadlo","year":"2012","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"35","key":"10.1016\/j.phrs.2016.12.016_bib0415","doi-asserted-by":"crossref","first-page":"23557","DOI":"10.1074\/jbc.M804116200","article-title":"Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis","volume":"283","author":"Butkinaree","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20101338","article-title":"Human OGA binds substrates in a conserved peptide recognition groove","volume":"432","author":"Schimpl","year":"2010","journal-title":"Biochem. J"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0425","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.chembiol.2012.01.011","article-title":"Synergy of peptide and sugar in O-GlcNAcase substrate recognition","volume":"19","author":"Schimpl","year":"2012","journal-title":"Chem. Biol."},{"issue":"45","key":"10.1016\/j.phrs.2016.12.016_bib0430","doi-asserted-by":"crossref","first-page":"14260","DOI":"10.1021\/jp804626j","article-title":"A quantum mechanics\/molecular mechanics study of the protein-ligand interaction of two potent inhibitors of human O-GlcNAcase: pUGNAc and NAG-thiazoline","volume":"112","author":"Lameira","year":"2008","journal-title":"J. Phys. Chem. B"},{"issue":"8","key":"10.1016\/j.phrs.2016.12.016_bib0435","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nchembio.96","article-title":"A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo","volume":"4","author":"Yuzwa","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0440","doi-asserted-by":"crossref","first-page":"H1715","DOI":"10.1152\/ajpheart.00337.2010","article-title":"Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner","volume":"299","author":"Laczy","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phrs.2016.12.016_bib0445","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1039\/B612154C","article-title":"Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor","volume":"42","author":"Shanmugasundaram","year":"2006","journal-title":"Chem. Commun. (Camb)."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0450","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1021\/ja065697o","article-title":"Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise","volume":"129","author":"Whitworth","year":"2007","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"10.1016\/j.phrs.2016.12.016_bib0455","first-page":"2944","article-title":"Proteomics and PUGNAcity will overcome questioning of insulin resistance induction by nonselective inhibition of O-GlcNAcase","volume":"13","author":"Dehennaut","year":"2013","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0460","doi-asserted-by":"crossref","first-page":"C178","DOI":"10.1152\/ajpcell.00162.2006","article-title":"Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc","volume":"292","author":"Champattanachai","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.016_bib0465","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1161\/CIRCULATIONAHA.107.730515","article-title":"Cardioprotection by N-acetylglucosamine linkage to cellular proteins","volume":"117","author":"Jones","year":"2008","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0470","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/01.shk.0000245031.31859.29","article-title":"The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels","volume":"27","author":"Zou","year":"2007","journal-title":"Shock"},{"issue":"20","key":"10.1016\/j.phrs.2016.12.016_bib0475","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1002\/pmic.201200549","article-title":"Identification of differentially expressed proteins by treatment with PUGNAc in 3T3-L1 adipocytes through analysis of ATP-binding proteome","volume":"13","author":"Lee","year":"2013","journal-title":"Proteomics"},{"issue":"50","key":"10.1016\/j.phrs.2016.12.016_bib0480","doi-asserted-by":"crossref","first-page":"34687","DOI":"10.1074\/jbc.M804525200","article-title":"Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance","volume":"283","author":"Macauley","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.016_bib0485","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.chembiol.2010.07.005","article-title":"Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis","volume":"17","author":"Macauley","year":"2010","journal-title":"Chem. Biol."},{"issue":"51","key":"10.1016\/j.phrs.2016.12.016_bib0490","doi-asserted-by":"crossref","first-page":"16484","DOI":"10.1021\/ja066743n","article-title":"GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels","volume":"128","author":"Dorfmueller","year":"2006","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"10.1016\/j.phrs.2016.12.016_bib0495","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.chembiol.2010.09.014","article-title":"Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases","volume":"17","author":"Dorfmueller","year":"2010","journal-title":"Chem. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0500","doi-asserted-by":"crossref","first-page":"H1711","DOI":"10.1152\/ajpheart.00553.2009","article-title":"O-GlcNAc signaling attenuates ER stress-induced cardiomyocyte death","volume":"297","author":"Ngoh","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0505","first-page":"422","article-title":"Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins","volume":"110","author":"Roos","year":"1998","journal-title":"Proc. Assoc. Am. Phys."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0510","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/abbi.1998.1016","article-title":"Elevated O-linked N-acetylglucosamine metabolism in pancreatic beta-cells","volume":"362","author":"Hanover","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0515","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/abbi.2000.2094","article-title":"Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells","volume":"383","author":"Gao","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0520","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/bbrc.2001.5607","article-title":"Cytosolic O-GlcNAc accumulation is not involved in beta-cell death in HIT-T15 or Min6","volume":"287","author":"Okuyama","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0525","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00726-010-0728-7","article-title":"Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes","volume":"40","author":"Ngoh","year":"2011","journal-title":"Amino Acids"},{"issue":"7","key":"10.1016\/j.phrs.2016.12.016_bib0530","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/glycob\/6.7.711","article-title":"O-GlcNAcylation of key nuclear and cytoskeletal proteins: reciprocity with O-phosphorylation and putative roles in protein multimerization","volume":"6","author":"Hart","year":"1996","journal-title":"Glycobiology"},{"issue":"8","key":"10.1016\/j.phrs.2016.12.016_bib0535","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1074\/mcp.M600453-MCP200","article-title":"Dynamic interplay between O-linked N-acetylglucosaminylation and glycogen synthase kinase-3-dependent phosphorylation","volume":"6","author":"Wang","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0540","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1046\/j.1432-1327.1999.00439.x","article-title":"O-linked N-acetylglucosamine levels in cerebellar neurons respond reciprocally to pertubations of phosphorylation","volume":"262","author":"Griffith","year":"1999","journal-title":"Eur. J. Biochem."},{"issue":"37","key":"10.1016\/j.phrs.2016.12.016_bib0545","doi-asserted-by":"crossref","first-page":"13793","DOI":"10.1073\/pnas.0806216105","article-title":"Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0550","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/glycob\/8.4.383","article-title":"SV40 large T antigen is modified with O-linked N-acetylglucosamine but not with other forms of glycosylation","volume":"8","author":"Medina","year":"1998","journal-title":"Glycobiology"},{"issue":"38","key":"10.1016\/j.phrs.2016.12.016_bib0555","doi-asserted-by":"crossref","first-page":"11609","DOI":"10.1021\/bi000755i","article-title":"Alternative O-glycosylation\/O-phosphorylation of the murine estrogen receptor beta","volume":"39","author":"Cheng","year":"2000","journal-title":"Biochemistry"},{"issue":"21","key":"10.1016\/j.phrs.2016.12.016_bib0560","doi-asserted-by":"crossref","first-page":"19229","DOI":"10.1074\/jbc.M201729200","article-title":"Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation\/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens","volume":"277","author":"Kamemura","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0565","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1046\/j.1471-4159.1999.0730418.x","article-title":"Glycosylation sites flank phosphorylation sites on synapsin I: O-linked N-acetylglucosamine residues are localized within domains mediating synapsin I interactions","volume":"73","author":"Cole","year":"1999","journal-title":"J. Neurochem."},{"issue":"14","key":"10.1016\/j.phrs.2016.12.016_bib0570","doi-asserted-by":"crossref","first-page":"10416","DOI":"10.1016\/S0021-9258(18)82216-5","article-title":"RNA polymerase II is a glycoprotein: modification of the COOH-terminal domain by O-GlcNAc","volume":"268","author":"Kelly","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"26","key":"10.1016\/j.phrs.2016.12.016_bib0575","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1021\/bi0027480","article-title":"Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase II","volume":"40","author":"Comer","year":"2001","journal-title":"Biochemistry"},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0580","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1016\/S0021-9258(19)50611-1","article-title":"Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18","volume":"267","author":"Chou","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"46","key":"10.1016\/j.phrs.2016.12.016_bib0585","doi-asserted-by":"crossref","first-page":"28741","DOI":"10.1074\/jbc.271.46.28741","article-title":"The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine","volume":"271","author":"Arnold","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0590","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1128\/MCB.24.4.1680-1690.2004","article-title":"Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability","volume":"24","author":"O'Donnell","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2006-9101","article-title":"Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation","volume":"9","author":"Gong","year":"2006","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0600","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbagen.2009.07.004","article-title":"The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses","volume":"1800","author":"Chatham","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.phrs.2016.12.016_bib0605","doi-asserted-by":"crossref","first-page":"H2122","DOI":"10.1152\/ajpheart.00775.2011","article-title":"O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy","volume":"302","author":"Facundo","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0610","doi-asserted-by":"crossref","first-page":"H138","DOI":"10.1152\/ajpheart.2002.282.1.H138","article-title":"Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats","volume":"282","author":"Abe","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0615","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.yjmcc.2006.09.015","article-title":"Glutamine-induced protection of isolated rat heart from ischemia\/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels","volume":"42","author":"Liu","year":"2007","journal-title":"J. Mol. Cell Cardiol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0620","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/01.shk.0000209563.07693.db","article-title":"Glucosamine administration during resuscitation improves organ function after trauma hemorrhage","volume":"25","author":"Yang","year":"2006","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0625","doi-asserted-by":"crossref","first-page":"C1509","DOI":"10.1152\/ajpcell.00456.2007","article-title":"Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2","volume":"294","author":"Champattanachai","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0630","doi-asserted-by":"crossref","first-page":"H515","DOI":"10.1152\/ajpheart.01025.2008","article-title":"Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling","volume":"296","author":"Zou","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"13\u201314","key":"10.1016\/j.phrs.2016.12.016_bib0635","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.clinbiochem.2007.05.002","article-title":"Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with type 2 diabetes: inter-relationships with hyperglycaemia and oxidative stress","volume":"40","author":"Srinivasan","year":"2007","journal-title":"Clin. Biochem.."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0640","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2337\/diab.45.3.302","article-title":"Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM","volume":"45","author":"Yki-Jarvinen","year":"1996","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0645","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.2337\/diabetes.54.4.1214","article-title":"A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans","volume":"54","author":"Lehman","year":"2005","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.phrs.2016.12.016_bib0650","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s001250051519","article-title":"Increased O-GlcNAc transferase in pancreas of rats with streptozotocin-induced diabetes","volume":"43","author":"Akimoto","year":"2000","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0655","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/abbi.2001.2331","article-title":"Hyperglycemia and the O-GlcNAc transferase in rat aortic smooth muscle cells: elevated expression and altered patterns of O-GlcNAcylation","volume":"389","author":"Akimoto","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0660","doi-asserted-by":"crossref","first-page":"E241","DOI":"10.1152\/ajpendo.00060.2002","article-title":"Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles","volume":"283","author":"Buse","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0665","doi-asserted-by":"crossref","first-page":"C1370","DOI":"10.1152\/ajpcell.00422.2006","article-title":"Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart","volume":"292","author":"Fulop","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0670","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1074\/jbc.M808518200","article-title":"Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose","volume":"284","author":"Hu","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0675","doi-asserted-by":"crossref","first-page":"H282","DOI":"10.1152\/ajpheart.00421.2008","article-title":"Interaction of diet and diabetes on cardiovascular function in rats","volume":"296","author":"Marsh","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0680","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2337\/db08-0994","article-title":"Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes","volume":"58","author":"Wang","year":"2009","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.phrs.2016.12.016_bib0685","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ncpcardio1347","article-title":"Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy","volume":"5","author":"Lebeche","year":"2008","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0690","doi-asserted-by":"crossref","first-page":"C139","DOI":"10.1152\/ajpcell.00020.2010","article-title":"Hyperglycemia-mediated activation of the hexosamine biosynthetic pathway results in myocardial apoptosis","volume":"299","author":"Rajamani","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0695","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2337\/diab.47.2.170","article-title":"Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes","volume":"47","author":"Nerlich","year":"1998","journal-title":"Diabetes"},{"issue":"45","key":"10.1016\/j.phrs.2016.12.016_bib0700","doi-asserted-by":"crossref","first-page":"44230","DOI":"10.1074\/jbc.M303810200","article-title":"Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation","volume":"278","author":"Clark","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.016_bib0705","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/01.RES.0000165478.06813.58","article-title":"Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart","volume":"96","author":"Hu","year":"2005","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.016_bib0710","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.2337\/diabetes.50.10.2363","article-title":"Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death","volume":"50","author":"Fiordaliso","year":"2001","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.phrs.2016.12.016_bib0715","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1021\/acs.jproteome.6b00250","article-title":"Comparative proteomics reveals dysregulated mitochondrial O-GlcNAcylation in diabetic hearts","volume":"15","author":"Ma","year":"2016","journal-title":"J. Proteome Res."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2016.12.016_bib0720","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0303-7207(02)00155-7","article-title":"Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion","volume":"194","author":"Liu","year":"2002","journal-title":"Mol. Cell Endocrinol."},{"issue":"1 Pt 2","key":"10.1016\/j.phrs.2016.12.016_bib0725","first-page":"H148","article-title":"Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes","volume":"272","author":"Ren","year":"1997","journal-title":"Am. J. Physiol."},{"issue":"1 Pt 2","key":"10.1016\/j.phrs.2016.12.016_bib0730","first-page":"H159","article-title":"Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes","volume":"272","author":"Davidoff","year":"1997","journal-title":"Am. J. Physiol."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.016_bib0735","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1006\/jmcc.2002.2035","article-title":"Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy","volume":"34","author":"Dutta","year":"2002","journal-title":"J. Mol. Cell Cardiol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0740","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.2337\/diabetes.50.5.1186","article-title":"Cardiomyocyte dysfunction in sucrose-fed rats is associated with insulin resistance","volume":"50","author":"Dutta","year":"2001","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.016_bib0745","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.yjmcc.2005.03.014","article-title":"Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats","volume":"39","author":"Wold","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"12","key":"10.1016\/j.phrs.2016.12.016_bib0750","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.2337\/diabetes.53.12.3201","article-title":"Decreased sarcoplasmic reticulum activity and contractility in diabetic db\/db mouse heart","volume":"53","author":"Belke","year":"2004","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0755","doi-asserted-by":"crossref","first-page":"H1398","DOI":"10.1152\/ajpheart.00313.2002","article-title":"Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats","volume":"283","author":"Choi","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0760","doi-asserted-by":"crossref","first-page":"R1787","DOI":"10.1152\/ajpregu.00059.2007","article-title":"Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes","volume":"293","author":"Lacombe","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0765","doi-asserted-by":"crossref","first-page":"H1607","DOI":"10.1152\/ajpheart.00525.2006","article-title":"Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms","volume":"292","author":"Armoundas","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0770","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0008-6363(98)00241-7","article-title":"Enhanced phosphorylation of phospholamban and downregulation of sarco\/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure","volume":"41","author":"Currie","year":"1999","journal-title":"Cardiovasc. Res."},{"issue":"1 Pt 1","key":"10.1016\/j.phrs.2016.12.016_bib0775","first-page":"E25","article-title":"Basis for myocardial mechanical defects associated with non-insulin-dependent diabetes","volume":"256","author":"Schaffer","year":"1989","journal-title":"Am. J. Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0780","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1006\/jmcc.2000.1139","article-title":"Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunction","volume":"32","author":"Depre","year":"2000","journal-title":"J. Mol. Cell Cardiol."},{"issue":"5 Pt 2","key":"10.1016\/j.phrs.2016.12.016_bib0785","first-page":"H1656","article-title":"Effects of diabetes on isometric tension as a function of [Ca2+] and pH in rat skinned cardiac myocytes","volume":"269","author":"Hofmann","year":"1995","journal-title":"Am. J. Physiol."},{"issue":"6 Pt 2","key":"10.1016\/j.phrs.2016.12.016_bib0790","first-page":"H2185","article-title":"Alterations in contractile properties and Ca2+ handling in streptozotocin-induced diabetic rat myocardium","volume":"277","author":"Ishikawa","year":"1999","journal-title":"Am. J. Physiol."},{"issue":"14","key":"10.1016\/j.phrs.2016.12.016_bib0795","doi-asserted-by":"crossref","first-page":"10360","DOI":"10.1074\/jbc.M606787200","article-title":"O-linked N-acetylglucosaminylation is involved in the Ca2+ activation properties of rat skeletal muscle","volume":"282","author":"Hedou","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0800","doi-asserted-by":"crossref","first-page":"H1313","DOI":"10.1152\/ajpheart.00816.2005","article-title":"Mechanical stress-strain sensors embedded in cardiac cytoskeleton: z disk, titin, and associated structures","volume":"290","author":"Hoshijima","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"12","key":"10.1016\/j.phrs.2016.12.016_bib0805","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/CIRCRESAHA.108.184978","article-title":"O-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function","volume":"103","author":"Ramirez-Correa","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2016.12.016_bib0810","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/978-1-4684-5107-8_35","article-title":"Diabetes mellitus and hypothyroidism induce changes in myosin isoenzyme distribution in the rat heart\u2013do alterations in fuel flux mediate these changes?","volume":"194","author":"Dillmann","year":"1986","journal-title":"Adv. Exp. Med. Biol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0815","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1007\/s00125-006-0229-0","article-title":"Cardiac contractile dysfunction in Lep\/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch","volume":"49","author":"Li","year":"2006","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.phrs.2016.12.016_bib0820","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/glycob\/cwq071","article-title":"Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy","volume":"20","author":"Yokoe","year":"2010","journal-title":"Glycobiology"},{"issue":"12","key":"10.1016\/j.phrs.2016.12.016_bib0825","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.2337\/diabetes.51.12.3461","article-title":"Hyperglycemia inhibits capacitative calcium entry and hypertrophy in neonatal cardiomyocytes","volume":"51","author":"Pang","year":"2002","journal-title":"Diabetes"},{"issue":"41","key":"10.1016\/j.phrs.2016.12.016_bib0830","doi-asserted-by":"crossref","first-page":"34419","DOI":"10.1074\/jbc.M112.393207","article-title":"Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent","volume":"287","author":"Zou","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.phrs.2016.12.016_bib0835","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/1440-1681.12489","article-title":"CaMKIIdelta and cardiomyocyte Ca(2+) signalling new perspectives on splice variant targeting","volume":"42","author":"Bell","year":"2015","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"7471","key":"10.1016\/j.phrs.2016.12.016_bib0840","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12537","article-title":"Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation","volume":"502","author":"Erickson","year":"2013","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.016_bib0845","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10741-015-9498-3","article-title":"The role of CaMKII in diabetic heart dysfunction","volume":"20","author":"Daniels","year":"2015","journal-title":"Heart Failure Rev."},{"key":"10.1016\/j.phrs.2016.12.016_bib0850","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ijcard.2015.09.022","article-title":"Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca(2+) release events in a rodent model of early stage diabetes: the arrhythmogenic substrate","volume":"202","author":"Sommese","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0855","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1172\/JCI65268","article-title":"Diabetes increases mortality after myocardial infarction by oxidizing CaMKII","volume":"123","author":"Luo","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2016.12.016_bib0860","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fphar.2014.00048","article-title":"CaMKII in sinoatrial node physiology and dysfunction","volume":"5","author":"Wu","year":"2014","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0865","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.2337\/diabetes.53.4.1074","article-title":"Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy","volume":"53","author":"Pang","year":"2004","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0870","doi-asserted-by":"crossref","first-page":"C57","DOI":"10.1152\/ajpcell.00263.2005","article-title":"Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine","volume":"290","author":"Nagy","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0875","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/jcp.20609","article-title":"Inhibition of phospholipase C-beta1-mediated signaling by O-GlcNAc modification","volume":"207","author":"Kim","year":"2006","journal-title":"J. Cell. Physiol."},{"issue":"46","key":"10.1016\/j.phrs.2016.12.016_bib0880","doi-asserted-by":"crossref","first-page":"39094","DOI":"10.1074\/jbc.M112.383778","article-title":"Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes","volume":"287","author":"Zhu-Mauldin","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0885","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00726-010-0699-8","article-title":"Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice","volume":"40","author":"Marsh","year":"2011","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0890","doi-asserted-by":"crossref","first-page":"H227","DOI":"10.1152\/ajpheart.00340.2004","article-title":"Profibrotic influence of high glucose concentration on cardiac fibroblast functions: effects of losartan and vitamin E","volume":"288","author":"Asbun","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0895","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.2337\/diabetes.51.4.1146","article-title":"Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation","volume":"51","author":"James","year":"2002","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0900","doi-asserted-by":"crossref","first-page":"F718","DOI":"10.1152\/ajprenal.2000.279.4.F718","article-title":"Overexpression of GFAT activates PAI-1 promoter in mesangial cells","volume":"279","author":"James","year":"2000","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.016_bib0905","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1172\/JCI119875","article-title":"High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells","volume":"101","author":"Kolm-Litty","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0910","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1161\/hy0302.105295","article-title":"Aldosterone and D-glucose stimulate the proliferation of human cardiac myofibroblasts in vitro","volume":"39","author":"Neumann","year":"2002","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.phrs.2016.12.016_bib0915","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.metabol.2004.01.006","article-title":"Direct effects of high glucose and insulin on protein synthesis in cultured cardiac myocytes and DNA and collagen synthesis in cardiac fibroblasts","volume":"53","author":"Tokudome","year":"2004","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.016_bib0920","doi-asserted-by":"crossref","first-page":"E713","DOI":"10.1152\/ajpendo.00108.2011","article-title":"O-linked beta-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells","volume":"301","author":"Goldberg","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.016_bib0925","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/CS20110638","article-title":"O-GlcNAcylation and oxidation of proteins: is signalling in the cardiovascular system becoming sweeter?","volume":"123","author":"Lima","year":"2012","journal-title":"Clin. Sci. (Lond)"},{"issue":"9","key":"10.1016\/j.phrs.2016.12.016_bib0930","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1172\/JCI11235","article-title":"Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site","volume":"108","author":"Du","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"22","key":"10.1016\/j.phrs.2016.12.016_bib0935","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.1073\/pnas.97.22.12222","article-title":"Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation","volume":"97","author":"Du","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0940","doi-asserted-by":"crossref","first-page":"666","DOI":"10.2337\/db06-0699","article-title":"Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes","volume":"56","author":"Thum","year":"2007","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.phrs.2016.12.016_bib0945","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/01.RES.0000248212.86638.e9","article-title":"Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells","volume":"99","author":"Gutierrez","year":"2006","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.016_bib0950","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00726-010-0719-8","article-title":"Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis","volume":"40","author":"Shin","year":"2011","journal-title":"Amino Acids"},{"issue":"7","key":"10.1016\/j.phrs.2016.12.016_bib0955","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI18127","article-title":"Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells","volume":"112","author":"Du","year":"2003","journal-title":"J. Clin. Invest."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181631338X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181631338X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T05:42:48Z","timestamp":1658036568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366181631338X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":191,"alternative-id":["S104366181631338X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.016","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}