{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:45:48Z","timestamp":1790790348617,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NHMRC Project Grant","award":["APP1049100"],"award-info":[{"award-number":["APP1049100"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.phrs.2016.12.032","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T09:40:25Z","timestamp":1482486025000},"page":"70-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension"],"prefix":"10.1016","volume":"116","author":[{"given":"Quynh N.","family":"Dinh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophocles","family":"Chrissobolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Diep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Ferens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant R.","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Sobey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9587","key":"10.1016\/j.phrs.2016.12.032_bib0005","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(07)61299-9","article-title":"Essential hypertension","volume":"370","author":"Messerli","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2016.12.032_bib0010","doi-asserted-by":"crossref","first-page":"406960","DOI":"10.1155\/2014\/406960","article-title":"Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension","volume":"2014","author":"Dinh","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.032_bib0015","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.clim.2005.08.004","article-title":"C-reactive protein: ligands, receptors and role in inflammation","volume":"117","author":"Marnell","year":"2005","journal-title":"Clin. Immunol."},{"issue":"7","key":"10.1016\/j.phrs.2016.12.032_bib0020","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.amjhyper.2004.03.675","article-title":"Association between prehypertension status and inflammatory markers related to atherosclerotic disease: the ATTICA Study","volume":"17","author":"Chrysohoou","year":"2004","journal-title":"Am. J. Hypertens."},{"issue":"22","key":"10.1016\/j.phrs.2016.12.032_bib0025","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1001\/jama.290.22.2945","article-title":"C-reactive protein and the risk of developing hypertension","volume":"290","author":"Sesso","year":"2003","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.phrs.2016.12.032_bib0030","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat. Med."},{"issue":"14","key":"10.1016\/j.phrs.2016.12.032_bib0035","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.jacc.2007.10.065","article-title":"Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging","volume":"51","author":"Najjar","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.032_bib0040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/hy0102.099031","article-title":"Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study","volume":"39","author":"Boutouyrie","year":"2002","journal-title":"Hypertension"},{"issue":"22","key":"10.1016\/j.phrs.2016.12.032_bib0045","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1161\/hc4601.099485","article-title":"Endothelial dysfunction: oxidative stress, and risk of cardiovascular events in patients with coronary artery disease","volume":"104","author":"Heitzer","year":"2001","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.phrs.2016.12.032_bib0050","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrd3403","article-title":"Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets","volume":"10","author":"Drummond","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.032_bib0055","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJM199007053230105","article-title":"Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension","volume":"323","author":"Panza","year":"1990","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.032_bib0060","doi-asserted-by":"crossref","first-page":"F1384","DOI":"10.1152\/ajprenal.00049.2010","article-title":"High-salt diet reveals the hypertensive and renal effects of reduced nephron endowment","volume":"298","author":"Ruta","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.032_bib0065","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.032_bib0070","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/HYPERTENSIONAHA.112.198770","article-title":"CD36 and Na\/K-ATPase-alpha1 form a proinflammatory signaling loop in kidney","volume":"61","author":"Kennedy","year":"2013","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.phrs.2016.12.032_bib0075","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/01.fjc.0000211788.37658.ad","article-title":"Severity of hyperlipidemia does not affect antiatherosclerotic effect of an angiotensin II receptor antagonist in apolipoprotein E-deficient mice","volume":"47","author":"Kato","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"12","key":"10.1016\/j.phrs.2016.12.032_bib0080","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jnutbio.2009.10.003","article-title":"Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall","volume":"21","author":"Guri","year":"2010","journal-title":"J. Nutr. Biochem."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.032_bib0085","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1161\/01.ATV.0000172631.50972.0f","article-title":"Vitamin E. inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice","volume":"25","author":"Gavrila","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.032_bib0090","doi-asserted-by":"crossref","first-page":"H1898","DOI":"10.1152\/ajpheart.01081.2010","article-title":"Low circulating insulin-like growth factor I increases atherosclerosis in ApoE-deficient mice","volume":"300","author":"Shai","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.032_bib0095","doi-asserted-by":"crossref","first-page":"e54625","DOI":"10.1371\/journal.pone.0054625","article-title":"Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice","volume":"8","author":"Weng","year":"2013","journal-title":"PLoS One"},{"issue":"24","key":"10.1016\/j.phrs.2016.12.032_bib0100","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1161\/CIRCULATIONAHA.106.611822","article-title":"Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation","volume":"113","author":"Miriyala","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.032_bib0105","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.atherosclerosis.2005.05.016","article-title":"Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice","volume":"184","author":"Ayabe","year":"2006","journal-title":"Atherosclerosis"},{"issue":"12","key":"10.1016\/j.phrs.2016.12.032_bib0110","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1161\/01.CIR.0000124061.78478.94","article-title":"Irbesartan but not amlodipine suppresses diabetes-associated atherosclerosis","volume":"109","author":"Candido","year":"2004","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.032_bib0115","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1161\/HYPERTENSIONAHA.115.05779","article-title":"Obligatory role for B cells in the development of angiotensin II-dependent hypertension","volume":"66","author":"Chan","year":"2015","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.032_bib0120","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/bph.13230","article-title":"Inflammasome activity is essential for one kidney\/deoxycorticosterone acetate\/salt-induced hypertension in mice","volume":"173","author":"Krishnan","year":"2016","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.032_bib0125","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20070657","article-title":"Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction","volume":"204","author":"Guzik","year":"2007","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.phrs.2016.12.032_bib0130","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1161\/CIRCULATIONAHA.111.034470","article-title":"Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction","volume":"124","author":"Wenzel","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.032_bib0135","doi-asserted-by":"crossref","first-page":"H24","DOI":"10.1152\/ajpheart.00799.2009","article-title":"Direct evidence of a role for Nox2 in superoxide production: reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE\u2212\/\u2212 mice","volume":"298","author":"Judkins","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.032_bib0140","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.HYP.0000247302.20559.3a","article-title":"Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging","volume":"48","author":"Didion","year":"2006","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.032_bib0145","doi-asserted-by":"crossref","first-page":"H1829","DOI":"10.1152\/ajpheart.00230.2009","article-title":"eNOS uncoupling and endothelial dysfunction in aged vessels","volume":"297","author":"Yang","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.032_bib0150","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1152\/jappl.1991.71.6.2224","article-title":"Forearm vascular resistance increases during static exercise in heart transplant recipients","volume":"71","author":"Morgan","year":"1991","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.phrs.2016.12.032_bib0155","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2741\/3816","article-title":"Oxidative stress and endothelial dysfunction in cerebrovascular disease","volume":"16","author":"Chrissobolis","year":"2011","journal-title":"Front. Biosci."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816313998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816313998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T20:42:22Z","timestamp":1538080942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816313998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":31,"alternative-id":["S1043661816313998"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.032","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}