{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:02:27Z","timestamp":1785214947218,"version":"3.55.0"},"reference-count":9,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.phrs.2016.12.033","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T18:01:06Z","timestamp":1482948066000},"page":"29-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Tacrine: In vivo veritas"],"prefix":"10.1016","volume":"116","author":[{"given":"Bevyn","family":"Jarrott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2016.12.033_bib0005","first-page":"160","article-title":"The influence of chemical constitution on antibacterial activity. Part II: A general survey of the acridine series","volume":"26","author":"Albert","year":"1945","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.phrs.2016.12.033_bib0010","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0301-0082(91)90002-I","article-title":"Tacrine: a pharmacological review","volume":"36","author":"Freeman","year":"1991","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phrs.2016.12.033_bib0015","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2165\/00003088-199528060-00003","article-title":"Clinical pharmacokinetics of tacrine","volume":"28","author":"Madden","year":"1995","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.phrs.2016.12.033_bib0020","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.bmcl.2013.02.017","article-title":"Novel tacrine-related drugs as potential candidates for the treatment of Alzheimers disease","volume":"23","author":"Romero","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phrs.2016.12.033_bib0025","doi-asserted-by":"crossref","first-page":"868","DOI":"10.5694\/j.1326-5377.1949.tb37429.x","article-title":"Some aspects of the pharmacology of morphine, with special reference to its antagonism by 5-amino-acridine and other chemically related compounds","author":"Shaw","year":"1949","journal-title":"Med. J. Aust. ii"},{"key":"10.1016\/j.phrs.2016.12.033_bib0030","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/169712a0","article-title":"Morphine antagonism","volume":"169","author":"Shaw","year":"1952","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2016.12.033_bib0035","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1136\/bmj.1.5224.471","article-title":"Treatment of intractable pain with morphine and tetrahydroaminacrine","volume":"1","author":"Stone","year":"1961","journal-title":"Brit. Med. J."},{"key":"10.1016\/j.phrs.2016.12.033_bib0040","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/15563658008989949","article-title":"THA- A review of the literature and its use in treatment of five overdose patients","volume":"16","author":"Summers","year":"1980","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.phrs.2016.12.033_bib0045","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3233\/JAD-2006-9S350","article-title":"Tacrine and Alzheimer\u2019s treatments","volume":"9","author":"Summers","year":"2006","journal-title":"J. Alzheimer\u2019s Dis."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816313974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816313974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T09:35:11Z","timestamp":1601285711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816313974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":9,"alternative-id":["S1043661816313974"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.033","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tacrine: In vivo veritas","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}