{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:40:51Z","timestamp":1786995651260,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science and Technology Development Fund of Macao"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.phrs.2017.08.014","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T22:15:58Z","timestamp":1504304158000},"page":"150-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"PB","title":["Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-\u03baB signaling"],"prefix":"10.1016","volume":"125","author":[{"given":"Lufen","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2017.08.014_bib0005","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1055\/s-2008-1081346","article-title":"Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis","volume":"74","author":"Xu","year":"2008","journal-title":"Planta Med."},{"key":"10.1016\/j.phrs.2017.08.014_bib0010","first-page":"041","article-title":"The Side Effects and Prevention of Drug Treatment by Zhengqingfengtongning","volume":"2","author":"Juanand","year":"2012","journal-title":"Chin. J. Med. Guide"},{"key":"10.1016\/j.phrs.2017.08.014_bib0015","first-page":"009","article-title":"Therapeutic effects and side effects of zhengqingfengtongning in the treatment of osteoarthritis","volume":"2","author":"Yonghong","year":"2001","journal-title":"Chin. J. Rehabil."},{"key":"10.1016\/j.phrs.2017.08.014_bib0020","article-title":"He Huiying Zhejiang Provincial TCM hospital, Hangzhou (310006); clinical analysis and prevention strategy on 32 cases of drug rash caused by Zhengqing Fengtong Ning","volume":"5","author":"Diwen","year":"2006","journal-title":"J. Zhejiang Univ. Trad. Chin. Med."},{"key":"10.1016\/j.phrs.2017.08.014_bib0025","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.intimp.2015.04.029","article-title":"Sinomenine potentiates degranulation of RBL-2H3 basophils via up-regulation of phospholipase A 2 phosphorylation by Annexin A1 cleavage and ERK phosphorylation without influencing on calcium mobilization","volume":"28","author":"Huang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0030","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1254\/jjp.3.62","article-title":"The release of histamine by sinomenine","volume":"3","author":"Mayeda","year":"1953","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0035","doi-asserted-by":"crossref","first-page":"958","DOI":"10.2183\/pjab1945.41.958","article-title":"Evidence for energy-requiring processes in mast cell degranulation and histamine release in rat induced by sinomenine","volume":"41","author":"Yamasaki","year":"1965","journal-title":"Proc. Jpn. Acad."},{"key":"10.1016\/j.phrs.2017.08.014_bib0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/all.12330","article-title":"Histamine and gut mucosal immune regulation","volume":"69","author":"Smolinska","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.phrs.2017.08.014_bib0045","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.anai.2013.11.010","article-title":"H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review","volume":"112","author":"Nurmatov","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nri2692","article-title":"Disease-associated functions of IL-33: the new kid in the IL-1 family","volume":"10","author":"Liew","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0055","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2009.04.081","article-title":"IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes","volume":"384","author":"Wood","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2017.08.014_bib0060","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.intimp.2015.01.012","article-title":"Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway","volume":"25","author":"Funakoshi-Tago","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0065","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejphar.2015.05.071","article-title":"Mast cell stabilisers","volume":"778","author":"Zhang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0070","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1046\/j.1365-2133.2000.03529.x","article-title":"Mast cell mediators other than histamine induced pruritus in atopic dermatitis patients-a dermal microdialysis study","volume":"142","author":"Greaves","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000438605","article-title":"Anti-allergic drugs tranilast and ketotifen dose-dependently exert mast cell-stabilizing properties","volume":"38","author":"Baba","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.phrs.2017.08.014_bib0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.taap.2011.04.008","article-title":"Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-\u03baB","volume":"254","author":"Bae","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0085","doi-asserted-by":"crossref","first-page":"9773","DOI":"10.1073\/pnas.0901206106","article-title":"The cytokine interleukin-33 mediates anaphylactic shock","volume":"106","author":"Pushparaj","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phrs.2017.08.014_bib0090","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1084\/jem.189.10.1573","article-title":"Modulation of immunoglobulin (Ig) E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG","volume":"189","author":"Ujike","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2017.08.014_bib0095","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1172\/JCI114025","article-title":"Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice","volume":"83","author":"Martin","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2017.08.014_bib0100","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/labinvest.2012.116","article-title":"Evidence questioning cromolyn\u2019s effectiveness and selectivity as a \u2018mast cell stabilizer\u2019in mice","volume":"92","author":"Oka","year":"2012","journal-title":"Lab. Invest."},{"key":"10.1016\/j.phrs.2017.08.014_bib0105","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1039\/c3an00036b","article-title":"N-phosphorylation labeling for analysis of twenty natural amino acids and small peptides by using matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry","volume":"138","author":"Gao","year":"2013","journal-title":"Analyst"},{"key":"10.1016\/j.phrs.2017.08.014_bib0110","series-title":"Guidelines for Preparing Color Figures for Everyone Including the Colorblind","author":"Roskoski","year":"2017"},{"key":"10.1016\/j.phrs.2017.08.014_bib0115","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1172\/JCI8253","article-title":"Adenosine and inosine increase cutaneous vasopermeability by activating A3 receptors on mast cells","volume":"105","author":"Tilley","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2017.08.014_bib0120","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jaci.2007.01.017","article-title":"Proximal signaling events in Fc\u03b5RI-mediated mast cell activation","volume":"119","author":"Kambayashiand","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1440-1711.2001.00983.x","article-title":"Regulation of the inflammatory response in asthma by mast cell products","volume":"79","author":"Hart","year":"2001","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0130","doi-asserted-by":"crossref","first-page":"e55763","DOI":"10.1371\/journal.pone.0055763","article-title":"SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2017.08.014_bib0135","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbadis.2011.06.013","article-title":"The two faces of mast cells in food allergy and allergic asthma: the possible concept of Yin Yang","volume":"1822","author":"Kraneveld","year":"2012","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol. Basis Disease"},{"key":"10.1016\/j.phrs.2017.08.014_bib0140","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2222.2007.02886.x","article-title":"The mast cell and allergic diseases: role in pathogenesis and implications for therapy","volume":"38","author":"Brown","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.phrs.2017.08.014_bib0145","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1196\/annals.1366.025","article-title":"The critical role of mast cells in allergy and inflammation","volume":"1088","author":"Theoharidesand","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.phrs.2017.08.014_bib0150","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.phrs.2017.08.014_bib0155","first-page":"dxu058","article-title":"The role of basophils and pro-allergic cytokines, TSLP and IL-33, in cutaneously-sensitized food allergy","author":"Muto","year":"2014","journal-title":"Int. Immunol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.phrs.2014.10.009","article-title":"Tranilast: a review of its therapeutic applications","volume":"91","author":"Darakhshanand","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2017.08.014_bib0165","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1177\/019459989210700605.2","article-title":"Mast cell stabilizers","volume":"107","author":"King","year":"1992","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.phrs.2017.08.014_bib0170","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1398-9995.2012.02859.x","article-title":"Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naive mice","volume":"67","author":"Komai-Koma","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.phrs.2017.08.014_bib0175","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1172\/JCI26150","article-title":"The H1 histamine receptor regulates allergic lung responses","volume":"116","author":"Bryce","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2017.08.014_bib0180","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1172\/JCI26150","article-title":"The H1 histamine receptor regulates allergic lung responses","volume":"116","author":"Bryce","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2017.08.014_bib0185","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1476-5381.2009.00561.x","article-title":"The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice","volume":"159","author":"Shiota","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0190","unstructured":"h.C.g.I. NCT00882024."},{"key":"10.1016\/j.phrs.2017.08.014_bib0195","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1161\/ATVBAHA.106.139089","article-title":"Histamine upregulates the expression of inducible nitric oxide synthase in human intimal smooth muscle cells via histamine H1 receptor and NF-\u03baB signaling pathway","volume":"27","author":"Tanimoto","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.phrs.2017.08.014_bib0200","doi-asserted-by":"crossref","first-page":"34538","DOI":"10.1074\/jbc.M504943200","article-title":"Phosphorylation of RelA\/p65 on serine 536 defines an I\u03baB\u03b1-independent NF-\u03baB pathway","volume":"280","author":"Sasaki","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2017.08.014_bib0205","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1089\/acm.2011.0370","article-title":"Expert consensus on the treatment of rheumatoid arthritis with Chinese patent medicines","volume":"19","author":"Zhao","year":"2013","journal-title":"J. Altern. Complement. Med."},{"key":"10.1016\/j.phrs.2017.08.014_bib0210","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-\u03baB: a key role in inflammatory diseases","volume":"107","author":"Takand","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2017.08.014_bib0215","doi-asserted-by":"crossref","first-page":"368","DOI":"10.22205\/sijbs\/2016\/v2\/i4\/103443","article-title":"Function of nuclear factor kappa B (NF-kB) in human diseases-a review","volume":"2","author":"Serasanambatiand","year":"2016","journal-title":"South Indian J. Biol. Sci."},{"key":"10.1016\/j.phrs.2017.08.014_bib0220","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/cells5010012","article-title":"The regulation of NF-\u03baB subunits by phosphorylation","volume":"5","author":"Christian","year":"2016","journal-title":"Cells"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181730796X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181730796X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T13:29:49Z","timestamp":1719408589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366181730796X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":44,"alternative-id":["S104366181730796X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2017.08.014","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-\u03baB signaling","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2017.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}