{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:18:01Z","timestamp":1792592281463,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.phrs.2017.11.003","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T08:46:48Z","timestamp":1510044408000},"page":"95-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":596,"special_numbering":"C","title":["Hypertension and cardiovascular risk: General aspects"],"prefix":"10.1016","volume":"129","author":[{"given":"Sverre E.","family":"Kjeldsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2017.11.003_bib0005","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.hjh.0000431740.32696.cc","article-title":"The task force for the management of arterial hypertension of the European society of hypertension (ESH) and of the European society of cardiology (ESC): 2013 ESH\/ESC guidelines for the management of arterial hypertension","volume":"31","year":"2013","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3109\/08037051.2013.812549","article-title":"The task force for the management of arterial hypertension of the European society of hypertension (ESH) and of the European society of cardiology (ESC): 2013 ESH\/ESC Guidelines for the management of arterial hypertension","volume":"22","year":"2013","journal-title":"Blood Press."},{"key":"10.1016\/j.phrs.2017.11.003_bib0015","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2017.11.003_bib0020","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/eurjhf\/hfp141","article-title":"Normal systolic blood pressure and risk of heart failure in US male physicians","volume":"11","author":"Britton","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.phrs.2017.11.003_bib0025","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ki.2009.439","article-title":"Prehypertension: is it relevant for nephrologists","volume":"77","author":"Kalaitzidis","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2017.11.003_bib0030","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/00004872-200304000-00013","article-title":"Blood pressure and cardiovascular disease in the Asia Pacific region","volume":"21","author":"Lawes","year":"2003","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0035","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.amjhyper.2006.08.004","article-title":"Blood pressure parameters and risk of fatal stroke, NHANES II mortality study","volume":"20","author":"Brown","year":"2007","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0040","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/01.CIR.96.1.308","article-title":"Hemodynamic patterns of age-related changes in blood pressure. The Framingham heart study","volume":"96","author":"Franklin","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2017.11.003_bib0045","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1161\/HYPERTENSIONAHA.112.201400","article-title":"On behalf of the MORGAM project impact of age on the importance of systolic and diastolic blood pressures for stroke risk: the MOnica, risk, genetics, archiving, and monograph (MORGAM) project","volume":"60","author":"Vishram","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2017.11.003_bib0050","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/01.HYP.30.6.1410","article-title":"Pulse pressure: a predictor of long-term cardiovascular mortality in a French male population","volume":"30","author":"Benetos","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2017.11.003_bib0055","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1001\/jama.1981.03310370017013","article-title":"Systolic blood pressure, arterial rigidity, and risk of stroke. the Framingham study","volume":"245","author":"Kannel","year":"1981","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2017.11.003_bib0060","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/S0895-7061(99)00252-6","article-title":"Risk stratification in hypertension: new insights from the Framingham study","volume":"13","author":"Kannel","year":"2000","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0065","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/01.HYP.37.5.1256","article-title":"Cardiovascular mortality in hypertensive men according to presence of associated risk factors","volume":"37","author":"Thomas","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2017.11.003_bib0070","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/0002-9343(72)90049-6","article-title":"Hypertension. Definitions, natural histories and consequences","volume":"52","author":"Pickering","year":"1972","journal-title":"Am. J. Med."},{"key":"10.1016\/j.phrs.2017.11.003_bib0075","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1097\/HJH.0b013e32832f4f6b","article-title":"Management of high blood pressure in children and adolescents: recommendations of the European society of hypertension","volume":"27","author":"Lurbe","year":"2009","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0080","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/HJH.0b013e3283282f65","article-title":"Differences in prevalence, awareness, treatment and control of hypertension between developing and developed countries","volume":"27","author":"Pereira","year":"2009","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0085","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1097\/HJH.0b013e328311ce04","volume":"26","author":"Costanzo","year":"2008","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0090","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/01.HYP.0000259106.77783.f8","article-title":"Using public health indicators to measure the success of hypertension control","volume":"49","author":"Cooper","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2017.11.003_bib0095","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1001\/jama.289.18.2363","article-title":"Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States","volume":"289","author":"Wolf-Maier","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2017.11.003_bib0100","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/eurheartj\/ehr045","article-title":"Stroke mortality and trends from 1990 to 2006 in 39 countries from Europe and Central Asia: implications for control of high blood pressure","volume":"32","author":"Redon","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2017.11.003_bib0105","first-page":"1300","article-title":"Prevention of coronary heart disease in clinical practice. Recommendations of the task force of the European society of cardiology, European atherosclerosis society and European society of hypertension","volume":"15","author":"Pyorala","year":"1994","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2017.11.003_bib0110","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham heart study","volume":"117","author":"D'Agostino","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2017.11.003_bib0115","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0195-668X(03)00114-3","article-title":"Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project","volume":"24","author":"Conroy","year":"2003","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2017.11.003_bib0120","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/hrt.2006.108167","article-title":"Adding social deprivation and family history to cardiovascular risk assessment: the ASSIGN score from the Scottish heart health extended cohort (SHHEC)","volume":"93","author":"Woodward","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.phrs.2017.11.003_bib0125","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1136\/bmj.39609.449676.25","article-title":"Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2","volume":"336","author":"Hippisley-Cox","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2017.11.003_bib0130","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/hc0302.102575","article-title":"Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study","volume":"105","author":"Assmann","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2017.11.003_bib0135","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1161\/CIRCULATIONAHA.108.814251","article-title":"C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men","volume":"118","author":"Ridker","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2017.11.003_bib0140","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/jama.297.6.611","article-title":"Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds risk score","volume":"297","author":"Ridker","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2017.11.003_bib0145","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jacc.2009.07.020","article-title":"Value and limitations of existing scores for the assessment of cardiovascular risk: a review for clinicians","volume":"54","author":"Cooney","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phrs.2017.11.003_bib0150","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/eurheartj\/ehs092","article-title":"The fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice. European guidelines on cardiovascular disease prevention in clinical practice (version 2012)","volume":"33","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2017.11.003_bib0155","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/eurheartj\/ehp546","article-title":"Risk prediction is improved by adding markers of subclinical organ damage to SCORE","volume":"31","author":"Sehestedt","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2017.11.003_bib0160","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1097\/HJH.0b013e328356c579","article-title":"Thresholds for pulse wave velocity, urine albumin creatinine ratio and left ventricular mass index using SCORE, Framingham and ESH\/ESC risk charts","volume":"30","author":"Sehestedt","year":"2012","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0165","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1097\/HJH.0b013e3283525715","article-title":"Cardiovascular risk assessment beyond systemic coronary risk estimation: a role for organ damage markers","volume":"30","author":"Volpe","year":"2012","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0170","first-page":"151","article-title":"1999 World Health Organization-international society of hypertension guidelines for the management of hypertension. Guidelines subcommittee","volume":"17","year":"1999","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0175","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/00004872-200311000-00002","article-title":"Guidelines committee 2003 World Health Organization (WHO)\/international society of hypertension (ISH) statement on management of hypertension","volume":"21","year":"2003","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2017.11.003_bib0180","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1177\/2047487317693949","article-title":"NORRISK 2: a Norwegian risk model for acute cerebral stroke and myocardial infarction","volume":"24","author":"Selmer","year":"2017","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.phrs.2017.11.003_bib0185","article-title":"New Norwegian guidlines for the preventing cardiovascular disease","author":"Klemsdal","year":"2017","journal-title":"J. Norw. Med. Assoc."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661817311180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661817311180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T06:29:34Z","timestamp":1535264974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661817311180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":37,"alternative-id":["S1043661817311180"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2017.11.003","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypertension and cardiovascular risk: General aspects","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2017.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}