{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:38:28Z","timestamp":1770327508099,"version":"3.49.0"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Environments, Genes and Chronic Disease Canadian Institutes for Health Research Team Grant","award":["144626"],"award-info":[{"award-number":["144626"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.phrs.2018.02.002","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T17:45:58Z","timestamp":1517852758000},"page":"52-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Therapies for gestational diabetes and their implications for maternal and offspring health: Evidence from human and animal studies"],"prefix":"10.1016","volume":"130","author":[{"given":"Gabriel M.","family":"Brawerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernon W.","family":"Dolinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2018.02.002_bib0005","unstructured":"World Health Organization, Obesity and Overweight, (2017). http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/en\/."},{"key":"10.1016\/j.phrs.2018.02.002_bib0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bpobgyn.2010.10.006","article-title":"Diabetes and obesity in pregnancy","volume":"25","author":"Simmons","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.2009.2014","article-title":"Prevalence and trends i obesity among US adults, 1999\u20132008","volume":"303","author":"Flegal","year":"2010","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.phrs.2018.02.002_bib0020","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2105\/AJPH.2009.172890","article-title":"Percentage of gestational diabetes mellitus attributable to overweight and obesity","volume":"100","author":"Kim","year":"2010","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.phrs.2018.02.002_bib0025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1203\/PDR.0b013e3182055ede","article-title":"Obesity in pregnancy: implications for the mother and lifelong health of the child. A consensus statement","volume":"69","author":"Poston","year":"2011","journal-title":"Pediatr. Res."},{"issue":"June","key":"10.1016\/j.phrs.2018.02.002_bib0030","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1471-0528.1963.tb04922.x","article-title":"Increase in plasma volume during normal pregnancy","volume":"40","author":"Hytten","year":"1963","journal-title":"J. Obs. Gynaecol. Br. Emp."},{"key":"10.1016\/j.phrs.2018.02.002_bib0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.ackd.2013.01.012","article-title":"Renal physiology of pregnancy","volume":"20","author":"Cheung","year":"2013","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.phrs.2018.02.002_bib0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fphar.2014.00065","article-title":"Physiologic and pharmacokinetic changes in pregnancy","volume":"5","author":"Costantine","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0045","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.mce.2015.12.020","article-title":"A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth","volume":"422","author":"Capobianco","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"312","key":"10.1016\/j.phrs.2018.02.002_bib0050","doi-asserted-by":"crossref","first-page":"E117","DOI":"10.1152\/ajpendo.00262.2016","article-title":"Effects of paternal obesity on growth and adiposity of male rat offspring","author":"Lecomte","year":"2017","journal-title":"Am. J. Physiol. \u2013 Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2018.02.002_bib0055","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.phrs.2018.02.002_bib0060","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0899-9007(97)00193-7","article-title":"Fetal nutrition, and disease in later life","volume":"13","author":"Barker","year":"1997","journal-title":"Nutrition"},{"key":"10.1016\/j.phrs.2018.02.002_bib0065","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal nutrition and cardiovascular disease in adult life","volume":"341","author":"Barker","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2018.02.002_bib0070","doi-asserted-by":"crossref","first-page":"E1451","DOI":"10.3390\/ijms18071451","article-title":"Maternal macronutrient consumption and the developmental origins of metabolic disease in the offspring","volume":"18","author":"Kereliuk","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2018.02.002_bib0075","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2337\/diab.29.12.1023","article-title":"Banting lecture 1980. Of pregnancy and progeny","volume":"29","author":"Freinkel","year":"1980","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2018.02.002_bib0080","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1900\/RDS.2008.5.194","article-title":"Gestational diabetes: pathogenesis and consequences to mother and offspring","volume":"5","author":"Kaaja","year":"2008","journal-title":"Rev. Diabet. Stud."},{"key":"10.1016\/j.phrs.2018.02.002_bib0085","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1038\/ijo.2008.240","article-title":"Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective","volume":"32","author":"Gluckman","year":"2008","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phrs.2018.02.002_bib0090","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.2337\/dc07-s206","article-title":"Increasing prevalence of gestational diabetes mellitus: a public health perspective","volume":"30","author":"Ferrara","year":"2007","journal-title":"Diabetes Care."},{"key":"10.1016\/j.phrs.2018.02.002_bib0095","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1001\/jama.286.20.2516","article-title":"Gestational diabetes mellitus","volume":"286","author":"Jovanovic","year":"2001","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.phrs.2018.02.002_bib0100","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1139\/bcb-2014-0141","article-title":"Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence","volume":"93","author":"Pereira","year":"2015","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0105","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrendo.2012.96","article-title":"Gestational diabetes mellitus: risks and management during and after pregnancy","volume":"8","author":"Buchanan","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0110","first-page":"240","article-title":"Effects of insulin on placental, fetal and maternal outcomes in gestational diabetes mellitus","volume":"30","author":"Arshad","year":"2014","journal-title":"Pak. J. Med. Sci."},{"key":"10.1016\/j.phrs.2018.02.002_bib0115","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1758-5996-7-S1-A80","article-title":"Risk factors for gestational diabetes mellitus in a sample of pregnant women diagnosed with the disease","volume":"7","author":"Pons","year":"2015","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.phrs.2018.02.002_bib0120","doi-asserted-by":"crossref","first-page":"j2563","DOI":"10.1136\/bmj.j2563","article-title":"Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons","volume":"357","author":"Persson","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2018.02.002_bib0125","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.2337\/dc15-S015","article-title":"12. Management of diabetes in pregnancy","volume":"38","author":"American Diabetes Association","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phrs.2018.02.002_bib0130","first-page":"1","article-title":"Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (Review)","volume":"6","author":"Brown","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.phrs.2018.02.002_bib0135","first-page":"903","article-title":"Effect of physical activity and\/or healthy eating on gdm risk: the dali lifestyle study","volume":"102","author":"Simmons","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2018.02.002_bib0140","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2337\/dc15-0511","article-title":"Gestational diabetes mellitus can be prevented by lifestyle intervention: the Finnish gestational diabetes prevention study (RADIEL): a randomized controlled trial","volume":"39","author":"Koivusalo","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phrs.2018.02.002_bib0145","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12966-017-0632-6","article-title":"A randomized controlled trial of exercise during pregnancy on maternal and neonatal outcomes: results from the PAMELA study","volume":"14","author":"da Silva","year":"2017","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"key":"10.1016\/j.phrs.2018.02.002_bib0150","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/bjsports-2012-091788","article-title":"Exercise during pregnancy and gestational diabetes-related adverse effects: a randomised controlled trial","volume":"47","author":"Barakat","year":"2013","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.phrs.2018.02.002_bib0155","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/humupd\/dmp050","article-title":"Maternal metabolism and obesity: modifiable determinants of pregnancy outcome","volume":"16","author":"Nelson","year":"2010","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.phrs.2018.02.002_bib0160","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1113\/jphysiol.2010.190033","article-title":"Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats","volume":"588","author":"Zambrano","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0165","doi-asserted-by":"crossref","first-page":"E1095","DOI":"10.1152\/ajpendo.00390.2006","article-title":"Resistance to high-fat diet in the female progeny of obese mice fed a control diet during the periconceptual, gestation, and lactation periods","volume":"292","author":"Gallou-Kabani","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2018.02.002_bib0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pbb.2010.04.017","article-title":"Maternal high fat feeding and gestational dietary restriction: effects on offspring body weight, food intake and hypothalamic gene expression over three generations in mice","volume":"97","author":"Giraudo","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2018.02.002_bib0175","doi-asserted-by":"crossref","first-page":"F312","DOI":"10.1152\/ajprenal.00123.2016","article-title":"Intrauterine growth restriction programs an accelerated age-related increase in cardiovascular risk in male offspring","volume":"311","author":"Dasinger","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0180","doi-asserted-by":"crossref","first-page":"E1061","DOI":"10.1152\/ajpendo.00213.2012","article-title":"Perinatal exercise improves glucose homeostasis in adult offspring","volume":"303","author":"Carter","year":"2012","journal-title":"AJP Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2018.02.002_bib0185","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1249\/MSS.0b013e31827de953","article-title":"Maternal exercise improves insulin sensitivity in mature rat offspring","volume":"45","author":"Carter","year":"2013","journal-title":"Med Sci Sport. Exercise"},{"key":"10.1016\/j.phrs.2018.02.002_bib0190","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ijo.2013.150","article-title":"Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism","volume":"39","author":"Vega","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phrs.2018.02.002_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep44650","article-title":"Exercise rescues obese mothers\u2019 insulin sensitivity, placental hypoxia and male offspring insulin sensitivity","volume":"7","author":"Fernandez-Twinn","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2018.02.002_bib0200","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2337\/db13-1848","article-title":"Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring","volume":"64","author":"Stanford","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2018.02.002_bib0205","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.2337\/db17-0098","article-title":"Maternal exercise improves glucose tolerance in female offspring","volume":"66","author":"Stanford","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2018.02.002_bib0210","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2337\/db13-1614","article-title":"Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1a gene and age-dependent metabolic dysfunction in the offspring","volume":"63","author":"Laker","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2018.02.002_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/jns.2014.55","article-title":"Maternal high-fat diet consumption impairs exercise performance in offspring","volume":"3","author":"Walter","year":"2014","journal-title":"J. Nutr. Sci."},{"key":"10.1016\/j.phrs.2018.02.002_bib0220","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1136\/bmj.312.7038.1053","article-title":"Drugs and the fetus","volume":"312","author":"Vallance","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2018.02.002_bib0225","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s40264-014-0253-9","article-title":"Safety considerations with pharmacological treatment of gestational diabetes mellitus","volume":"38","author":"Simmons","year":"2015","journal-title":"Drug Saf."},{"key":"10.1016\/j.phrs.2018.02.002_bib0230","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s11892-016-0802-y","article-title":"Pharmacological management of gestational diabetes mellitus","volume":"16","author":"Bergel","year":"2016","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.phrs.2018.02.002_bib0235","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1023\/A:1021162117177","article-title":"Insulin and the thrifty women: the influence of insulin during pregnancy on gestational weight gain and postpartum weight retention","volume":"6","author":"Scholl","year":"2002","journal-title":"Matern. Child Health J."},{"key":"10.1016\/j.phrs.2018.02.002_bib0240","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1007\/s00125-016-4047-8","article-title":"A novel validated model for the prediction of insulin therapy initiation and adverse perinatal outcomes in women with gestational diabetes mellitus","volume":"59","author":"Barnes","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2018.02.002_bib0245","doi-asserted-by":"crossref","first-page":"E1203","DOI":"10.3390\/ijms18061203","article-title":"Insulin treatment may alter fatty acid carriers in placentas from gestational diabetes subjects","volume":"18","author":"Ruiz-Palacios","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2018.02.002_bib0250","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1007\/s00125-017-4318-z","article-title":"Metformin: historical overview","volume":"60","author":"Bailey","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2018.02.002_bib0255","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(98)07037-8","article-title":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)","volume":"352","author":"Turner","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2018.02.002_bib0260","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.2337\/dc11-1153","article-title":"Metformin therapy during pregnancy: good for the goose and good for the gosling too?","volume":"34","author":"Feig","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phrs.2018.02.002_bib0265","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00125-017-4342-z","article-title":"The mechanisms of action of metformin","volume":"60","author":"Rena","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2018.02.002_bib0270","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1007\/s00125-017-4351-y","article-title":"Metformin use in pregnancy: promises and uncertainties","volume":"60","author":"Lindsay","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2018.02.002_bib0275","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1056\/NEJMoa0707193","article-title":"Metformin versus insulin for the treatment of gestational diabetes","volume":"358","author":"Rowan","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2018.02.002_bib0280","first-page":"227","article-title":"Short-term antidiabetic treatment with insulin or metformin has a similar impact on the components of metabolic syndrome in women with gestational diabetes mellitus requiring antidiabetic agents: results of a prospective, randomised study","volume":"67","author":"Zawiejska","year":"2016","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0285","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1210\/jc.2014-3761","article-title":"The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the diabetes prevention program outcomes study 10-year follow-up","volume":"100","author":"Aroda","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2018.02.002_bib0290","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.2337\/dc11-0660","article-title":"Metformin in gestational diabetes: the offspring follow-up","volume":"34","author":"Rowan","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phrs.2018.02.002_bib0295","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/1471-0528.12964","article-title":"A follow-up of a randomised study of metformin and insulin in gestational diabetes mellitus: growth and development of the children at the age of 18 months","volume":"122","author":"Ijas","year":"2015","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0300","doi-asserted-by":"crossref","first-page":"F488","DOI":"10.1136\/archdischild-2015-309602","article-title":"Neurodevelopmental outcome at 2\u2005years in offspring of women randomised to metformin or insulin treatment for gestational diabetes","volume":"101","author":"Wouldes","year":"2016","journal-title":"Arch. Dis. Child. \u2013 Fetal Neonatal Ed."},{"key":"10.1016\/j.phrs.2018.02.002_bib0305","doi-asserted-by":"crossref","first-page":"e56594","DOI":"10.1371\/journal.pone.0056594","article-title":"Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood","volume":"8","author":"Salom\u00e4ki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2018.02.002_bib0310","first-page":"1","article-title":"Impact of metformin on reproductive tissues: an overview from gametogenesis to gestation","volume":"2","author":"Bertoldo","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phrs.2018.02.002_bib0315","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1093\/humrep\/des264","article-title":"Metformin exposure affects human and mouse fetal testicular cells","volume":"27","author":"Tartarin","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.phrs.2018.02.002_bib0320","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/dmrr.2451","article-title":"Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy","volume":"30","author":"Lee","year":"2014","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.phrs.2018.02.002_bib0325","doi-asserted-by":"crossref","first-page":"757913","DOI":"10.5402\/2012\/757913","article-title":"Oral metformin treatment prevents enhanced insulin demand and placental dysfunction in the pregnant rat fed a fructose-rich diet","volume":"2012","author":"Alzamendi","year":"2012","journal-title":"ISRN Endocrinol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nutd.2011.3","article-title":"Metformin mitigates the impaired development of skeletal muscle in the offspring of obese mice","volume":"1","author":"Tong","year":"2011","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.phrs.2018.02.002_bib0335","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1007\/s00125-014-3379-5","article-title":"Exposure of embryonic pancreas to metformin enhances the number of pancreatic protenitors","volume":"57","author":"Gregg","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2018.02.002_bib0340","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.apjtm.2015.12.018","article-title":"Effect of insulin and metformin on methylation and glycolipid metabolism of peroxisome proliferator-activated receptor \u03b3 coactivator-1A of rat offspring with gestational diabetes mellitus","volume":"9","author":"Song","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.phrs.2018.02.002_bib0345","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/17425255.2016.1187131","article-title":"Pharmacokinetics, efficacy and safety of glyburide for treatment of gestational diabetes mellitus","volume":"12","author":"Malek","year":"2016","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0350","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1056\/NEJM200010193431601","article-title":"A comparison of glyburide and insulin in women with gestational diabetes mellitus","volume":"343","author":"Langer","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2018.02.002_bib0355","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1517\/17425255.2016.1124413","article-title":"Effects of antidiabetic agents on pancreatic beta-cell function in gestational diabetes: is there enough evidence?","volume":"12","author":"Tura","year":"2016","journal-title":"Exp. Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0360","first-page":"214","article-title":"Examining the starting dose of glyburide in gestational diabetes","volume":"33","author":"Glover","year":"2016","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0365","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1124\/dmd.110.033837","article-title":"Increased glyburide clearance in the pregnant mouse model","volume":"38","author":"Zhou","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phrs.2018.02.002_bib0370","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/clpt.2008.1","article-title":"Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study","volume":"84","author":"Hebert","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2018.02.002_bib0375","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/AOG.0000000000000672","article-title":"Glyburide transport across the human placenta","volume":"125","author":"Schwartz","year":"2015","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0380","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/clpt.2009.5","article-title":"Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice","volume":"85","author":"Hebert","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2018.02.002_bib0385","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1124\/jpet.110.165639","article-title":"Impact of hyperlipidemia on plasma protein binding and hepatic drug transporter and metabolic enzyme regulation in a rat model of gestational diabetes","volume":"334","author":"Anger","year":"2010","journal-title":"J. Pharmacol. Exp."},{"key":"10.1016\/j.phrs.2018.02.002_bib0390","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.placenta.2017.05.016","article-title":"Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight","volume":"57","author":"D\u00edaz","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.phrs.2018.02.002_bib0395","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1080\/09513590.2016.1209479","article-title":"Insulin detemir versus glyburide in women with gestational diabetes mellitus","volume":"3590","author":"Koren","year":"2016","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0400","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/jamapediatrics.2015.74","article-title":"Association of adverse pregnancy outcomes with glyburide vs insulin in women with gestational diabetes","volume":"169","author":"Camelo Castillo","year":"2015","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.phrs.2018.02.002_bib0405","first-page":"97","article-title":"Comparison of glyburide and insulin in women with gestational diabetes mellitus and associated perinatal outcome: a randomized clinical trial","volume":"53","author":"Mirzamoradi","year":"2015","journal-title":"Acta Med. Iran."},{"key":"10.1016\/j.phrs.2018.02.002_bib0410","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1124\/jpet.114.213470","article-title":"Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age","volume":"350","author":"Shuster","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2018.02.002_bib0415","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s001250050348","article-title":"Glyburide crosses the placenta in vivo in pregnant rats","volume":"38","author":"Sivan","year":"1995","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2018.02.002_bib0420","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5455\/OVJ.2014.v4.i1.p59","article-title":"Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus","volume":"4","author":"Aguillar-Gomes","year":"2014","journal-title":"Open Vet. J."},{"key":"10.1016\/j.phrs.2018.02.002_bib0425","doi-asserted-by":"crossref","first-page":"h102","DOI":"10.1136\/bmj.h102","article-title":"Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis","volume":"350","author":"Balsells","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2018.02.002_bib0430","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2337\/dc16-2307","article-title":"Glyburide versus metformin and their combination for the treatment of gestational diabetes mellitus: a randomized controlled study","volume":"40","author":"Nachum","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phrs.2018.02.002_bib0435","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s40261-015-0289-3","article-title":"Comparison of glyburide with metformin in treating gestational diabetes mellitus: a systematic review and meta-analysis","volume":"35","author":"Amin","year":"2015","journal-title":"Clin. Drug Investig."},{"key":"10.1016\/j.phrs.2018.02.002_bib0440","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/AOG.0000000000000967","article-title":"Glyburide in women with mild gestational diabetes: a randomized controlled trial","volume":"126","author":"Casey","year":"2015","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0445","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/ajo.12276","article-title":"Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide \u2013 a randomised controlled trial","volume":"55","author":"George","year":"2015","journal-title":"Aust. N. Zeal. J. Obstet. Gynaecol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0450","first-page":"6189820","article-title":"Inositols in the treatment of insulin-mediated diseases","volume":"2016","author":"Muscogiuri","year":"2016","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0455","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ajog.2016.05.038","article-title":"The effect of combined inositol supplementation on maternal metabolic profile in pregnancies complicated by metabolic syndrome and obesity","volume":"215","author":"Ferrari","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"141","key":"10.1016\/j.phrs.2018.02.002_bib0460","doi-asserted-by":"crossref","first-page":"E141","DOI":"10.3390\/nu9020141","article-title":"The effects of myo-Inositol and B and D vitamin supplementation in the db\/+ mouse model of gestational diabetes mellitus","volume":"9","author":"Plows","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2018.02.002_bib0465","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0002-9378(97)70543-X","article-title":"Dietary intake of myo-inositol and neural tube defects in offspring of diadetic rats","volume":"176","author":"Reece","year":"1997","journal-title":"Am. J. Obs. Gynecol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0470","doi-asserted-by":"crossref","first-page":"e1604","DOI":"10.1097\/MD.0000000000001604","article-title":"Relationship between myo-inositol supplementary and gestational diabetes mellitus: a meta-analysis","volume":"94","author":"Zheng","year":"2015","journal-title":"Medicine (Baltimore)."},{"key":"10.1016\/j.phrs.2018.02.002_bib0475","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.3390\/ijms15046298","article-title":"Maternal high folic acid supplement promotes glucose intolerance and insulin resistance in male mouse offspring fed a high-fat diet","volume":"15","author":"Huang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2018.02.002_bib0480","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/ijo.2013.41","article-title":"Obesity affects short-term folate pharmacokinetics in women of childbearing age","volume":"37","author":"da Silva","year":"2013","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phrs.2018.02.002_bib0485","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1507\/endocrj.K08E-180","article-title":"Folic acid prevents congenital malformations in the offspring of diabetic mice","volume":"56","author":"Oyama","year":"2009","journal-title":"Endocr. J."},{"key":"10.1016\/j.phrs.2018.02.002_bib0490","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.reprotox.2007.03.007","article-title":"Folic acid supplementation affects ROS scavenging enzymes, enhances Vegf-A, and diminishes apoptotic state in yolk sacs of embryos of diabetic rats","volume":"23","author":"Zabihi","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0495","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/mnfr.201300615","article-title":"Metabolic effects of a high-fat diet post-weaning after low maternal dietary folate during pregnancy and lactation","volume":"58","author":"Mckay","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phrs.2018.02.002_bib0500","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.2337\/dc15-2389","article-title":"Folic acid supplement intake in early pregnancy increases risk of gestational diabetes mellitus: evidence from a prospective cohort study","volume":"39","author":"Zhu","year":"2016","journal-title":"Diabetes Care."},{"key":"10.1016\/j.phrs.2018.02.002_bib0505","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1017\/S204017441400035X","article-title":"Supplementation with methyl donors during lactation to high-fat-sucrose-fed dams protects offspring against liver fat accumulation when consuming an obesogenic diet","volume":"5","author":"Cordero","year":"2014","journal-title":"J. Dev. Orig. Health Dis."},{"issue":"May","key":"10.1016\/j.phrs.2018.02.002_bib0510","first-page":"S3","article-title":"Dietary fat consumption and health","author":"Lichtenstein","year":"1998","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.phrs.2018.02.002_bib0515","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3945\/ajcn.111.022590","article-title":"Effect of reducing the n6: n3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial","volume":"95","author":"Hauner","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phrs.2018.02.002_bib0520","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/sj.ijo.0803211","article-title":"N-3 fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring","volume":"30","author":"Yessoufou","year":"2006","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.phrs.2018.02.002_bib0525","doi-asserted-by":"crossref","first-page":"368107","DOI":"10.1155\/2014\/368107","article-title":"Effect of dietary n \u2013 3 polyunsaturated fatty acids on oxidant\/antioxidant status in macrosomic offspring of diabetic rats","volume":"2014","author":"Guermouche","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phrs.2018.02.002_bib0530","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.bbadis.2011.06.010","article-title":"Calorie restriction and resveratrol in cardiovascular health and disease","volume":"1812","author":"Dolinsky","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2018.02.002_bib0535","doi-asserted-by":"crossref","first-page":"14919","DOI":"10.3390\/molecules190914919","article-title":"Experimental studies of the molecular pathways regulated by exercise and resveratrol in heart, skeletal muscle and the vasculature","volume":"19","author":"Dolinsky","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.phrs.2018.02.002_bib0540","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5603\/CJ.a2013.0051","article-title":"Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress","volume":"21","author":"Mohammadshahi","year":"2014","journal-title":"Cardiol. J."},{"key":"10.1016\/j.phrs.2018.02.002_bib0545","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10863-012-9429-0","article-title":"Resveratrol and diabetic cardiac function: focus on recent in vitro and in vivo studies","volume":"44","author":"Turan","year":"2012","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.phrs.2018.02.002_bib0550","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1096\/fj.13-245472","article-title":"Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates","volume":"28","author":"Roberts","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.phrs.2018.02.002_bib0555","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/1535370212473704","article-title":"Diabetic complications in pregnancy: is resveratrol a solution?","volume":"238","author":"Singh","year":"2013","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.phrs.2018.02.002_bib0560","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12958-015-0114-0","article-title":"Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK","volume":"13","author":"Yao","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0565","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.placenta.2012.01.012","article-title":"Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia","volume":"33","author":"Bourque","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.phrs.2018.02.002_bib0570","first-page":"1547","article-title":"Resveratrol supplementation to high fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring","author":"Zou","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0575","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbrep.2016.12.011","article-title":"Maternal resveratrol intake during lactation attenuates hepatic triglyceride and fatty acid synthesis in adult male rat offspring","volume":"9","author":"Tanaka","year":"2017","journal-title":"Biochem. Biophys. Reports"},{"key":"10.1016\/j.phrs.2018.02.002_bib0580","doi-asserted-by":"crossref","first-page":"E395","DOI":"10.3390\/molecules22030395","article-title":"Cancer chemoprevention by phytochemicals: nature\u2019s healing touch","volume":"22","author":"Zubair","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.phrs.2018.02.002_bib0585","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1203\/00006450-200106000-00007","article-title":"Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy","volume":"49","author":"Cederberg","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.phrs.2018.02.002_bib0590","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1007\/s001250050844","article-title":"Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats","volume":"40","author":"Sim\u00e1n","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2018.02.002_bib0595","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.2337\/db10-0301","article-title":"Maternal antioxidant supplementation prevents adiposity in the offspring of western diet-fed rats","volume":"59","author":"Sen","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2018.02.002_bib0600","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.3109\/14767058.2016.1154526","article-title":"Role of antioxidants in gestational diabetes mellitus and relation to fetal outcome: a randomized controlled trial","volume":"7058","author":"Maged","year":"2016","journal-title":"J. Matern. Neonatal Med."},{"key":"10.1016\/j.phrs.2018.02.002_bib0605","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(06)68433-X","article-title":"Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial","volume":"367","author":"Poston","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2018.02.002_bib0610","first-page":"1","article-title":"Vitamin D and its impact on maternal-fetal outcomes in pregnancy: a critical review","volume":"8398","author":"Agarwal","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phrs.2018.02.002_bib0615","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s40618-017-0696-9","article-title":"Low maternal circulating levels of vitamin D as potential determinant in the development of gestational diabetes mellitus","author":"Triunfo","year":"2017","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.phrs.2018.02.002_bib0620","first-page":"356","article-title":"Immunohistochemical localization of the 1, 25 (OH) 2D3 receptor and calbindin D28k in human and rat pancreas","volume":"267","author":"Johnson","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.phrs.2018.02.002_bib0625","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jcjd.2017.01.003","article-title":"The relationship between 25-hydroxyvitamin d levels, insulin sensitivity and insulin secretion in women 3 years after delivery","author":"T\u00e4nczer","year":"2017","journal-title":"Can. J. Diabetes"},{"key":"10.1016\/j.phrs.2018.02.002_bib0630","first-page":"1","article-title":"Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin","author":"Mousa","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phrs.2018.02.002_bib0635","doi-asserted-by":"crossref","first-page":"e0164999","DOI":"10.1371\/journal.pone.0164999","article-title":"Vitamin D deficiency increases the risk of adverse neonatal outcomes in gestational diabetes","volume":"11","author":"Schwerz Weinert","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2018.02.002_bib0640","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3892\/ijmm.2015.2300","article-title":"The effects of vitamin D3 on lipogenesis in the liver and adipose tissue of pregnant rats","author":"Kang","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phrs.2018.02.002_bib0645","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3177\/jnsv.59.367","article-title":"Transgenerational effects on the liver and pancreas resulting from maternal vitamin D restriction in mice","volume":"59","author":"Nascimento","year":"2013","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"10.1016\/j.phrs.2018.02.002_bib0650","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3109\/14767058.2014.913133","article-title":"Little beneficial effect of maternal vitamin supplement on metabolic disturbances in the offspring from the obese mother mice","volume":"28","author":"Huang","year":"2015","journal-title":"J. Matern. Neonatal Med."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661817313488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661817313488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T23:59:59Z","timestamp":1719791999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661817313488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":130,"alternative-id":["S1043661817313488"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2018.02.002","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapies for gestational diabetes and their implications for maternal and offspring health: Evidence from human and animal studies","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2018.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}