{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:38:34Z","timestamp":1790393914985,"version":"4.1.0"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","award":["20-3997\/NRPU\/R&D\/HEC\/14"],"award-info":[{"award-number":["20-3997\/NRPU\/R&D\/HEC\/14"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.phrs.2018.06.030","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T13:33:47Z","timestamp":1530365627000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Serotonin-1A receptor dependent modulation of pain and reward for improving therapy of chronic pain"],"prefix":"10.1016","volume":"134","author":[{"given":"Darakhshan Jabeen","family":"Haleem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2018.06.030_bib0005","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.berh.2014.08.002","article-title":"Burden of disability due to musculoskeletal (MSK) disorders","volume":"28","author":"March","year":"2014","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0010","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jpain.2016.12.018","article-title":"Patient-reported outcomes and opioid use in outpatients with chronic pain","volume":"18","author":"Witkin","year":"2017","journal-title":"J. Pain"},{"key":"10.1016\/j.phrs.2018.06.030_bib0015","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.289.18.2370","article-title":"Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities","volume":"289","author":"Rosenblum","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2018.06.030_bib0020","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1526-4637.2008.00420.x","article-title":"Prevalence and characteristics of chronic pain in patients admitted to an outpatient drug and alcohol treatment program","volume":"9","author":"Sheu","year":"2008","journal-title":"Pain Med."},{"key":"10.1016\/j.phrs.2018.06.030_bib0025","first-page":"219","article-title":"The pharmacological basis of opioids","volume":"12","author":"Ghelardini","year":"2015","journal-title":"Clin. Cases Miner Bone Metab."},{"key":"10.1016\/j.phrs.2018.06.030_bib0030","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.00005.2009","article-title":"Reward processing by the opioid system in the brain","volume":"89","author":"Le Merrer","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2018.06.030_bib0035","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pnpbp.2013.07.015","article-title":"Extending therapeutic use of psychostimulants: focus on serotonin-1A receptor","volume":"46","author":"Haleem","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.phrs.2018.06.030_bib0040","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40122-017-0091-4","article-title":"Pharmacotherapy for neuropathic pain: a review","volume":"6","author":"Fornasari","year":"2017","journal-title":"Pain Ther."},{"key":"10.1016\/j.phrs.2018.06.030_bib0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jpain.2016.10.001","article-title":"Inhibition of reinforcing, hyperalgesic, and motor effects of morphine by buspirone in rats","volume":"18","author":"Haleem","year":"2017","journal-title":"J. Pain"},{"key":"10.1016\/j.phrs.2018.06.030_bib0050","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1017\/S1461145708008766","article-title":"Role of serotonin 5-HT1A receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice","volume":"12","author":"Berrocoso","year":"2009","journal-title":"Int. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0055","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2018.06.030_bib0060","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.sjpain.2017.03.001","article-title":"A neurobiologist\u2019s attempt to understand persistent pain","volume":"15","author":"Brodal","year":"2017","journal-title":"Scand. J. Pain"},{"key":"10.1016\/j.phrs.2018.06.030_bib0065","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrn3516","article-title":"Cognitive and emotional control of pain and its disruption in chronic pain","volume":"14","author":"Bushnell","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phrs.2018.06.030_bib0070","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nn.3153","article-title":"Corticostriatal functional connectivity predicts transition to chronic back pain","volume":"15","author":"Baliki","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2018.06.030_bib0075","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrrheum.2013.138","article-title":"Towards a mechanism-based approach to pain management in osteoarthritis","volume":"9","author":"Malfait","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0080","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1460-9568.2010.07351.x","article-title":"Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn","volume":"32","author":"Liu","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2018.06.030_bib0085","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s40263-015-0255-x","article-title":"Targeting opioid-induced hyperalgesia in clinical treatment: neurobiological considerations","volume":"29","author":"Arout","year":"2015","journal-title":"CNS Drugs"},{"key":"10.1016\/j.phrs.2018.06.030_bib0090","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fphar.2015.00104","article-title":"Opioid-induced hyperalgesia in chronic pain patients and the mitigating effects of gabapentin","volume":"6","author":"Stoicea","year":"2015","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2018.06.030_bib0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/j.pain.0000000000000342","article-title":"GluN2B N-methyl-D-aspartate receptor and excitatory amino acid transporter 3 are upregulated in primary sensory neurons after 7 days of morphine administration in rats: implication for opiate-induced hyperalgesia","volume":"157","author":"Gong","year":"2016","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.phrs.2018.06.030_bib0100","doi-asserted-by":"crossref","first-page":"145","DOI":"10.36076\/ppj.2011\/14\/145","article-title":"A comprehensive review of opioid-induced hyperalgesia","volume":"14","author":"Lee","year":"2011","journal-title":"Pain Phys."},{"key":"10.1016\/j.phrs.2018.06.030_bib0105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/jicd.12087","article-title":"Relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain: a literature review","volume":"5","author":"de Avila","year":"2014","journal-title":"J. Investig. Clin. Dent."},{"key":"10.1016\/j.phrs.2018.06.030_bib0110","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/ALN.0b013e318238bba6","article-title":"Molecular mechanisms of opioid receptor-dependent signaling and behavior","volume":"115","author":"Al-Hasani","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.phrs.2018.06.030_bib0115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/19336950.2015.1069450","article-title":"The mechanism of \u03bc-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependence","volume":"9","author":"Bao","year":"2015","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.phrs.2018.06.030_bib0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2165\/11630070-000000000-00000","article-title":"Pain mechanism in patients with chronic pain","volume":"32","author":"Fornasari","year":"2012","journal-title":"Clin. Drug Invest."},{"key":"10.1016\/j.phrs.2018.06.030_bib0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112483","article-title":"Analgesic mechanisms of antidepressants for neuropathic pain","volume":"18","author":"Obata","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2018.06.030_bib0130","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.forsciint.2016.02.033","article-title":"The cutting of cocaine and heroin: a critical review","volume":"262","author":"Bros\u00e9us","year":"2016","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.phrs.2018.06.030_bib0135","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuint.2017.04.017","article-title":"Upregulation of IRAS\/nischarin (I1-imidazoline receptor), a regulatory protein of \u03bc-opioid receptor trafficking, in postmortem prefrontal cortex of long-term opiate and mixed opiate\/cocaine abusers","volume":"108","author":"Keller","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phrs.2018.06.030_bib0140","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/npp.2015.340","article-title":"Blunted endogenous opioid release following an oral amphetamine challenge in pathological gamblers","volume":"41","author":"Mick","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2018.06.030_bib0145","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.biopsych.2006.11.016","article-title":"Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis","volume":"62","author":"Job","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2018.06.030_bib0150","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.neuropharm.2012.11.022","article-title":"Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system","volume":"67","author":"Kawahara","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2018.06.030_bib0155","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s00429-013-0599-2","article-title":"Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal","volume":"219","author":"Sun","year":"2014","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.phrs.2018.06.030_bib0160","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.tins.2015.01.002","article-title":"Understanding opioid reward","volume":"38","author":"Fields","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2018.06.030_bib0165","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.neuron.2014.04.030","article-title":"Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal","volume":"82","author":"Matsui","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2018.06.030_bib0170","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.tips.2003.10.005","article-title":"Opioid hyperalgesia and tolerance versus 5-HT1A receptor-mediated inverse tolerance","volume":"24","author":"Xu","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2018.06.030_bib0175","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1097\/MJT.0000000000000019","article-title":"Remifentanil-acute opioid tolerance and opioid-induced hyperalgesia: a systematic review","volume":"22","author":"Kim","year":"2015","journal-title":"Am. J. Ther."},{"issue":"2013","key":"10.1016\/j.phrs.2018.06.030_bib0180","article-title":"Chronic opioid therapy and opioid tolerance: a new hypothesis","author":"Goldberg","year":"2013","journal-title":"Pain Res. Treat."},{"key":"10.1016\/j.phrs.2018.06.030_bib0185","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bpa.2006.12.004","article-title":"The impact of opioid-induced hyperalgesia for postoperative pain","volume":"21","author":"Koppert","year":"2007","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0190","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.pain.2009.12.002","article-title":"The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation","volume":"148","author":"da Costa","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2018.06.030_bib0195","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.brainresbull.2012.09.018","article-title":"The role of non-synaptic extracellular glutamate","volume":"93","author":"Rodriguez","year":"2013","journal-title":"Brain Res. Bull."},{"issue":"6","key":"10.1016\/j.phrs.2018.06.030_bib0200","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.pain.2011.02.007","article-title":"Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans","volume":"152","author":"Lenz","year":"2011","journal-title":"Pain."},{"key":"10.1016\/j.phrs.2018.06.030_bib0205","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1385\/MN:30:2:117","article-title":"Serotonin in pain and analgesia: actions in the periphery","volume":"30","author":"Sommer","year":"2004","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0210","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(02)00009-6","article-title":"Descending control of pain","volume":"66","author":"Millan","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0215","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1152\/jn.00836.2016","article-title":"Descending antinociception induced by secondary somatosensory cortex stimulation in experimental neuropathy: role of the medullospinal serotonergic pathway","volume":"117","author":"Sagalajev","year":"2017","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0220","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/SPC.0000000000000055","article-title":"Descending pain modulation and chronification of pain","volume":"8","author":"Ossipov","year":"2014","journal-title":"Curr. Opin. Support Palliat Care"},{"key":"10.1016\/j.phrs.2018.06.030_bib0225","doi-asserted-by":"crossref","first-page":"15","DOI":"10.33549\/physiolres.931903","article-title":"Serotonin receptors - from molecular biology to clinical applications","volume":"60","author":"Pytliak","year":"2011","journal-title":"Physiol. Res."},{"key":"10.1016\/j.phrs.2018.06.030_bib0230","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2174\/1570159X15666170911121027","article-title":"Review: 5-Ht1, 5-Ht2, 5-Ht3, and 5-Ht7 receptors and their role in the modulation of pain response in the central nervous system","volume":"16","author":"Cortes-Altamirano","year":"2018","journal-title":"Curr. Neuropharmacol."},{"issue":"10","key":"10.1016\/j.phrs.2018.06.030_bib0235","first-page":"272","article-title":"What do we really know about 5-HT1A receptor signaling in neuronal cells?","volume":"10","author":"Rojas","year":"2016","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.phrs.2018.06.030_bib0240","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00213-013-3389-x","article-title":"5-HT(1A) [corrected] receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function","volume":"231","author":"Garcia-Garcia","year":"2014","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.phrs.2018.06.030_bib0245","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.2174\/1389450117666151209123049","article-title":"Drug targets for obesity and depression: from serotonin to leptin","volume":"17","author":"Haleem","year":"2016","journal-title":"Curr. Drug Targets"},{"issue":"3","key":"10.1016\/j.phrs.2018.06.030_bib0250","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0304-3959(02)00026-X","article-title":"Expression of 5-HT1A receptor mRNA in rat lumbar spinal dorsal horn neurons after peripheral inflammation","volume":"98","author":"Zhang","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2018.06.030_bib0255","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.98","article-title":"Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord","volume":"2","author":"Perrin","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phrs.2018.06.030_bib0260","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1002\/cne.21665","article-title":"Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descendingcontrol circuits","volume":"507","author":"Braz","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0265","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1097\/00001756-200010200-00020","article-title":"Expression of 5-HT1A receptor mRNA in rat dorsal raphe nucleus and ventrolateral periaqueductal gray neurons after peripheral inflammation","volume":"11","author":"Zhang","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.phrs.2018.06.030_bib0270","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/WNR.0b013e3283614cbf","article-title":"5-hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons","volume":"24","author":"Choi","year":"2013","journal-title":"Neuroreport"},{"key":"10.1016\/j.phrs.2018.06.030_bib0275","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3959(94)90184-8","article-title":"Serotonin and pain: evidence that activation of 5-HT1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice","volume":"58","author":"Millan","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2018.06.030_bib0280","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejphar.2017.06.023","article-title":"Synergic stimulation of serotonin 5 HT1 Areceptor and \u03b12-adrenoceptors for neuropathic pain relief: preclinical effects of 2-substituted imidazoline derivatives","volume":"810","author":"Di Cesare Mannelli","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0285","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuron.2009.12.003","article-title":"5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants","volume":"65","author":"Richardson-Jones","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2018.06.030_bib0290","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1074\/jbc.M111.293027","article-title":"Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice","volume":"287","author":"Czesak","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2018.06.030_bib0295","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pain.2006.11.015","article-title":"Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-\/-, 5-HT1B-\/-, 5-HT2A-\/-, 5-HT3A-\/- and 5-HTT-\/- knock-out male mice","volume":"130","author":"Kayser","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2018.06.030_bib0300","first-page":"201","article-title":"Buspirone attenuates tolerance to analgesic effect of morphine in mice with skin cancer","volume":"23","author":"Nayebi","year":"2010","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.phrs.2018.06.030_bib0305","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pbb.2007.04.007","article-title":"Reversal of haloperidol-induced tardive vacuous chewing movements and supersensitive somatodendritic serotonergic response by buspirone in rats","volume":"87","author":"Haleem","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2018.06.030_bib0310","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.neuroscience.2007.09.036","article-title":"The role of 5-HT receptor subtypes in the ventrolateral orbital cortex of 5-HT-induced antinociception in the rat","volume":"152","author":"Qu","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2018.06.030_bib0315","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1177\/0269216310378546","article-title":"Effectiveness of antiepileptic or antidepressant drugs when added to opioids for cancer pain: systematic review","volume":"25","author":"Bennett","year":"2011","journal-title":"Palliat. Med."},{"key":"10.1016\/j.phrs.2018.06.030_bib0320","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jclinane.2017.03.049","article-title":"The effect of ondansetron on analgesic efficacy of acetaminophen after hysterectomy: a randomized double blinded placebo controlled trial","volume":"40","author":"Koyuncu","year":"2017","journal-title":"J. Clin. Anesth."},{"key":"10.1016\/j.phrs.2018.06.030_bib0325","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainres.2007.07.036","article-title":"Correlation o human cold pressor reponse with 5-HT(1A) receptor binding in the brain","volume":"1172","author":"Martikainen","year":"2007","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.phrs.2018.06.030_bib0330","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0304-3959(89)90134-6","article-title":"Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain","volume":"37","author":"Kishore-Kumar","year":"1989","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2018.06.030_bib0335","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1472-6904-9-12","article-title":"Effects of buspirone on thermal sensory and pain thresholds in human volunteers","volume":"9","author":"Pavlakovi\u0107","year":"2009","journal-title":"BMC Clin. Pharmacol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0340","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.peptides.2013.10.001","article-title":"Endogenous opiates and behavior","volume":"50","author":"Bodnar","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.phrs.2018.06.030_bib0345","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1172\/JCI43766","article-title":"Central modulation of pain","volume":"120","author":"Ossipov","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2018.06.030_bib0350","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/j.1476-5381.2011.01685.x","article-title":"Role of 5-HT(1) receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn","volume":"165","author":"Jeong","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0355","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.pain.2013.02.019","article-title":"Adaptations in responsiveness of brainstem pain-modulating neurons in acute compared with chronic inflammation","volume":"154","author":"Cleary","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2018.06.030_bib0360","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/sj.bjp.0706859","article-title":"Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist, F13714: a microdialysis study in the rat","volume":"149","author":"Assi\u00e9","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0365","first-page":"35","article-title":"Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy","volume":"4","author":"Albert","year":"2010","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.phrs.2018.06.030_bib0370","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/jn.01062.2010","article-title":"Opioid receptor modulation of GABAergic and serotonergic spinally projecting neurons of the rostral ventromedial medulla in mice","volume":"106","author":"Pedersen","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0375","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.neuropharm.2012.07.023","article-title":"GABA, but not opioids, mediates the anti-hyperalgesic effects of 5-HT7 receptor activation in rats suffering from neuropathic pain","volume":"63","author":"Viguier","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2018.06.030_bib0380","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neuropharm.2017.06.022","article-title":"The effects of analgesics on central processing of tonic pain: a cross-over placebo controlled study","volume":"123","author":"Lelic","year":"2017","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.phrs.2018.06.030_bib0385","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/sj.clpt.6100018","article-title":"The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans","volume":"81","author":"Oertel","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2018.06.030_bib0390","first-page":"152","article-title":"Dopamine signaling in reward-related behaviors","volume":"7","author":"Baik","year":"2013","journal-title":"Front. Neural Circ."},{"key":"10.1016\/j.phrs.2018.06.030_bib0395","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroscience.2016.05.017","article-title":"Modulation of pain, nociception, and analgesia by the brain reward center","volume":"338","author":"Mitsi","year":"2016","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.phrs.2018.06.030_bib0400","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s13311-017-0525-z","article-title":"Reward circuitry in addiction","volume":"14","author":"Cooper","year":"2017","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.phrs.2018.06.030_bib0405","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/syn.20122","article-title":"Dopamine and serotonin release in dorsal striatum and nucleus accumbens is differentially modulated by morphine in DBA\/2J and C57BL\/6J mice","volume":"56","author":"Fadda","year":"2005","journal-title":"Synapse"},{"issue":"9","key":"10.1016\/j.phrs.2018.06.030_bib0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024865","article-title":"Repeated exposure to methamphetamine, cocaine or morphine induces augmentation of dopamine release in rat mesocorticolimbic slice co-cultures","volume":"6","author":"Nakagawa","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.phrs.2018.06.030_bib0415","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00210-003-0803-7","article-title":"Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine releases at the nucleus accumbens","volume":"368","author":"Huang","year":"2003","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2018.06.030_bib0420","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jnr.20537","article-title":"Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area","volume":"81","author":"Sotomayor","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.phrs.2018.06.030_bib0425","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.npep.2016.01.007","article-title":"The effect of Gly-Gln [\u00df-endorphin30-31] on morphine-evoked serotonin and GABA efflux in the nucleus accumbens of conscious rats","volume":"58","author":"Basaran","year":"2016","journal-title":"Neuropeptides"},{"issue":"1","key":"10.1016\/j.phrs.2018.06.030_bib0430","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.euroneuro.2015.11.009","article-title":"Effects of cocaine history on postsynaptic GABA receptors on dorsal raphe serotonin neurons in a stress-induced relapse model in rats","volume":"26","author":"Li","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2018.06.030_bib0435","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnbeh.2014.00008","article-title":"VTA GABA neurons modulate specific learning behaviors through the control of dopamine and cholinergic systems","volume":"8","author":"Creed","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"10","key":"10.1016\/j.phrs.2018.06.030_bib0440","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012096","article-title":"The neurobiology of opiate motivation","volume":"2","author":"Ting-A-Kee","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.phrs.2018.06.030_bib0445","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pbb.2018.05.010","article-title":"Dopamine and serotonin metabolism associated with morphine reward and its inhibition with buspirone: a study in the rat striatum","volume":"170","author":"Haleem","year":"2018","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"42","key":"10.1016\/j.phrs.2018.06.030_bib0450","doi-asserted-by":"crossref","first-page":"14029","DOI":"10.1523\/JNEUROSCI.3366-10.2010","article-title":"Opioid-induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area","volume":"30","author":"Madhavan","year":"2010","journal-title":"J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2018.06.030_bib0455","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejphar.2007.10.020","article-title":"Role of GABAA receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats","volume":"580","author":"Aono","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2018.06.030_bib0460","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ejphar.2007.12.008","article-title":"Role of GABA B receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamineefflux in the nucleus accumbens of freely moving rats","volume":"581","author":"Saigusa","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.phrs.2018.06.030_bib0465","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuropharm.2008.07.011","article-title":"Glutamate transmission in addiction","author":"Kalivas","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2018.06.030_bib0470","first-page":"404","article-title":"Glutamatergic transmission in drug reward: implications for drug addiction","volume":"9","author":"D\u2019Souza","year":"2015","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2018.06.030_bib0475","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pbb.2012.03.009","article-title":"Lesion of medial prefrontal cortex reduces morphine-induced extracellular dopamine level in the ventral tegmental area: a microdialysis study in rats","volume":"102","author":"Shahidani","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2018.06.030_bib0480","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.pbb.2015.06.004","article-title":"Blockage of acquisition and expression of morphine-induced conditioned place preference in rats due to activation of glutamate receptors type II\/III in nucleus accumbens","volume":"135","author":"Baharlouei","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.phrs.2018.06.030_bib0485","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/WNR.0000000000000708","article-title":"The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels","volume":"128","author":"Ferrada","year":"2017","journal-title":"Neuroreport"},{"issue":"1","key":"10.1016\/j.phrs.2018.06.030_bib0490","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1124\/pr.114.009514","article-title":"Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder","volume":"67","author":"Howell","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phrs.2018.06.030_bib0495","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pharmthera.2017.07.014","article-title":"The central serotonin2B receptor as a new pharmacological target for the treatment of dopamine-related neuropsychiatric disorders: rationale and current status of research","volume":"181","author":"Devroye","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2018.06.030_bib0500","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2014.10.008","article-title":"Serotonin revisited","volume":"277","author":"M\u00fcller","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"11","key":"10.1016\/j.phrs.2018.06.030_bib0505","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1212\/WNL.0b013e3181b784e7","article-title":"Serotonergic modulation of basal ganglia circuits: complexity and therapeutic opportunities","volume":"73","author":"Benarroch","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2018.06.030_bib0510","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00213-006-0680-0","article-title":"Postsynaptic 5-HT1A receptor stimulation increases motor activity in the 6-hydroxydopamine-lesioned rat: implications for treating Parkinson\u2019s disease","volume":"192","author":"Mignon","year":"2007","journal-title":"Psychopharmacology (Berl)."},{"issue":"2","key":"10.1016\/j.phrs.2018.06.030_bib0515","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.neuropharm.2011.08.031","article-title":"Dopamine D2 and serotonin 5-HT1A receptors mediate the actions of aripiprazole in mesocortical and mesoaccumbens transmission","volume":"62","author":"Tanahashi","year":"2012","journal-title":"Neuropharmacology"},{"issue":"47","key":"10.1016\/j.phrs.2018.06.030_bib0520","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1523\/JNEUROSCI.2999-05.2005","article-title":"Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action","volume":"25","author":"D\u00edaz-Mataix","year":"2005","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.phrs.2018.06.030_bib0525","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuroscience.2008.08.033","article-title":"Involvement of glutamate neurotransmission and N-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat","volume":"156","author":"Gronier","year":"2008","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.phrs.2018.06.030_bib0530","first-page":"753","article-title":"Motor effects of buspirone: relationship with dopamine and serotonin in the striatum","volume":"15","author":"Shireen","year":"2005","journal-title":"J. Coll. Phys. Surg. Pak."},{"key":"10.1016\/j.phrs.2018.06.030_bib0535","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1021\/acschemneuro.5b00021","article-title":"Functional interplay between dopaminergic and serotonergic neuronal systems during development and adulthood","volume":"6","author":"Niederkofler","year":"2015","journal-title":"ACS Chem. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2018.06.030_bib0540","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.pnpbp.2004.08.003","article-title":"Somatodendritic and postsynaptic serotonin-1A receptors in the attenuation of haloperidol-induced catalepsy","volume":"28","author":"Haleem","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"7","key":"10.1016\/j.phrs.2018.06.030_bib0545","doi-asserted-by":"crossref","first-page":"748","DOI":"10.4088\/JCP.14f09279","article-title":"Focus on addiction: buspirone for cocaine relapse and monitoring controlled substances prescribed to dually diagnosed patients","volume":"75","author":"Langleben","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phrs.2018.06.030_bib0550","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2012.04.032","article-title":"Buspirone: what is it all about?","volume":"1461","author":"Loane","year":"2012","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.phrs.2018.06.030_bib0555","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1017\/S1461145712000661","article-title":"Modification of cocaine self-administration by buspirone (buspar\u00ae): potential involvement of D3 and D4 dopamine receptors","volume":"16","author":"Bergman","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818306145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818306145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:56:47Z","timestamp":1760911007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818306145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":111,"alternative-id":["S1043661818306145"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2018.06.030","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serotonin-1A receptor dependent modulation of pain and reward for improving therapy of chronic pain","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2018.06.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}