{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:55:10Z","timestamp":1784127310620,"version":"3.55.0"},"reference-count":271,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"am","delay-in-days":356,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIAAA11147"],"award-info":[{"award-number":["NIAAA11147"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.phrs.2018.08.010","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T05:25:33Z","timestamp":1535001933000},"page":"2-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases"],"prefix":"10.1016","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2472-7672","authenticated-orcid":false,"given":"Amit U.","family":"Joshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Mochly-Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tcb.2012.10.006","article-title":"Mitochondrial dynamics in neurodegeneration","volume":"23","author":"Itoh","year":"2013","journal-title":"Trends Cell Biol."},{"issue":"6098","key":"10.1016\/j.phrs.2018.08.010_bib0010","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0015","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib0020","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1074\/mcp.M500298-MCP200","article-title":"Quantitative proteomic comparison of rat mitochondria from muscle, heart, and liver","volume":"5","author":"Forner","year":"2006","journal-title":"Mol. Cell Proteomics"},{"issue":"12","key":"10.1016\/j.phrs.2018.08.010_bib0025","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1084\/jem.20160776","article-title":"Potential biomarkers to follow the progression and treatment response of Huntington\u2019s disease","volume":"213","author":"Disatnik","year":"2016","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0168-8278(88)80024-2","article-title":"Subcellular changes and apoptosis induced by ethanol in rat liver","volume":"6","author":"Benedetti","year":"1988","journal-title":"J. Hepatol."},{"issue":"5-6","key":"10.1016\/j.phrs.2018.08.010_bib0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1054\/ceca.2000.0167","article-title":"Age-related structural and functional changes of brain mitochondria","volume":"28","author":"Toescu","year":"2000","journal-title":"Cell Calcium"},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0040","doi-asserted-by":"crossref","first-page":"223","DOI":"10.18388\/abp.1999_4156","article-title":"Structural changes of mitochondria related to apoptosis: swelling and megamitochondria formation","volume":"46","author":"Wakabayashi","year":"1999","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.phrs.2018.08.010_bib0045","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-physiol-021115-105011","article-title":"Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function","volume":"78","author":"Pernas","year":"2016","journal-title":"Annu. Rev. Physiol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0050","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2018.08.010_bib0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1749-6632.2010.05615.x","article-title":"Physiological functions of mitochondrial fusion","volume":"1201","author":"Chen","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0060","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011072","article-title":"Mechanisms of mitochondrial fission and fusion","volume":"5","author":"van der Bliek","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib0065","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.molcel.2016.02.022","article-title":"Mitofusins, from mitochondria to metabolism","volume":"61","author":"Schrepfer","year":"2016","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib0070","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.201511036","article-title":"Metabolic regulation of mitochondrial dynamics","volume":"212","author":"Mishra","year":"2016","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0075","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbamcr.2012.08.004","article-title":"The dynamin GTPase OPA1: more than mitochondria?","volume":"1833","author":"Belenguer","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"22","key":"10.1016\/j.phrs.2018.08.010_bib0080","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.15252\/embj.201488349","article-title":"OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand","volume":"33","author":"Patten","year":"2014","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0085","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1091\/mbc.01-12-0588","article-title":"Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae","volume":"13","author":"Dimmer","year":"2002","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0090","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00018-012-1066-6","article-title":"Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates","volume":"70","author":"Zhao","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phrs.2018.08.010_bib0095","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1146\/annurev.biochem.76.071905.090048","article-title":"The machines that divide and fuse mitochondria","volume":"76","author":"Hoppins","year":"2007","journal-title":"Annu. Rev. Biochem."},{"issue":"12","key":"10.1016\/j.phrs.2018.08.010_bib0100","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrm3013","article-title":"Mitochondrial fusion and fission in cell life and death","volume":"11","author":"Westermann","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0105","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physrev.00030.2008","article-title":"Mitochondrial dynamics in mammalian health and disease","volume":"89","author":"Liesa","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2018.08.010_bib0110","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.genet.38.072902.093019","article-title":"Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes","volume":"39","author":"Okamoto","year":"2005","journal-title":"Annu. Rev. Genet."},{"issue":"48","key":"10.1016\/j.phrs.2018.08.010_bib0115","doi-asserted-by":"crossref","first-page":"50286","DOI":"10.1074\/jbc.M405531200","article-title":"Mitochondria-specific function of the dynamin family protein DLP1 is mediated by its C-terminal domains","volume":"279","author":"Pitts","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.phrs.2018.08.010_bib0120","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1091\/mbc.10.12.4403","article-title":"The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells","volume":"10","author":"Pitts","year":"1999","journal-title":"Mol. Biol. Cell"},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib0125","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/13014","article-title":"The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast","volume":"1","author":"Bleazard","year":"1999","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.143.2.333","article-title":"The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast","volume":"143","author":"Otsuga","year":"1998","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib0135","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1534-5807(01)00055-7","article-title":"The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis","volume":"1","author":"Frank","year":"2001","journal-title":"Dev. Cell"},{"issue":"18","key":"10.1016\/j.phrs.2018.08.010_bib0140","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1242\/jcs.199562","article-title":"The constriction and scission machineries involved in mitochondrial fission","volume":"130","author":"Kraus","year":"2017","journal-title":"J. Cell. Sci."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0145","first-page":"127","article-title":"Mechanism of mitochondrial fission - structure and function of Drp1 protein","volume":"62","author":"Michalska","year":"2016","journal-title":"Postepy Biochem."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0150","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1083\/jcb.200903065","article-title":"The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice","volume":"186","author":"Wakabayashi","year":"2009","journal-title":"J. Cell Biol."},{"issue":"17","key":"10.1016\/j.phrs.2018.08.010_bib0155","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1056\/NEJMoa064436","article-title":"A lethal defect of mitochondrial and peroxisomal fission","volume":"356","author":"Waterham","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.phrs.2018.08.010_bib0160","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/ejhg.2015.243","article-title":"DNM1L-related mitochondrial fission defect presenting as refractory epilepsy","volume":"24","author":"Vanstone","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"issue":"8","key":"10.1016\/j.phrs.2018.08.010_bib0165","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1002\/ajmg.a.37721","article-title":"A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy","volume":"170","author":"Fahrner","year":"2016","journal-title":"Am. J. Med. Genet. A"},{"issue":"18","key":"10.1016\/j.phrs.2018.08.010_bib0170","doi-asserted-by":"crossref","first-page":"11692","DOI":"10.1074\/jbc.M114.610881","article-title":"The mechanoenzymatic core of dynamin-related protein 1 comprises the minimal machinery required for membrane constriction","volume":"290","author":"Francy","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0175","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1083\/jcb.143.2.351","article-title":"A human dynamin-related protein controls the distribution of mitochondria","volume":"143","author":"Smirnova","year":"1998","journal-title":"J. Cell Biol."},{"issue":"Pt 6","key":"10.1016\/j.phrs.2018.08.010_bib0180","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1242\/jcs.059246","article-title":"Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1","volume":"123","author":"Mai","year":"2010","journal-title":"J. Cell. Sci."},{"issue":"7631","key":"10.1016\/j.phrs.2018.08.010_bib0185","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nature20555","article-title":"Multiple dynamin family members collaborate to drive mitochondrial division","volume":"540","author":"Lee","year":"2016","journal-title":"Nature"},{"issue":"38","key":"10.1016\/j.phrs.2018.08.010_bib0190","doi-asserted-by":"crossref","first-page":"36373","DOI":"10.1074\/jbc.M303758200","article-title":"hFis1, a novel component of the mammalian mitochondrial fission machinery","volume":"278","author":"James","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0195","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbrc.2005.05.154","article-title":"Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating protein","volume":"333","author":"Jofuku","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"47","key":"10.1016\/j.phrs.2018.08.010_bib0200","doi-asserted-by":"crossref","first-page":"18526","DOI":"10.1073\/pnas.0706441104","article-title":"Structural basis for recruitment of mitochondrial fission complexes by Fis1","volume":"104","author":"Zhang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0205","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1083\/jcb.200503148","article-title":"The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria","volume":"170","author":"Griffin","year":"2005","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0210","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00018-017-2603-0","article-title":"The ever-growing complexity of the mitochondrial fission machinery","volume":"75","author":"Pagliuso","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0215","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1083\/jcb.201007152","article-title":"Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells","volume":"191","author":"Otera","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2018.08.010_bib0220","doi-asserted-by":"crossref","first-page":"e01612","DOI":"10.7554\/eLife.01612","article-title":"Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy","volume":"3","author":"Yamano","year":"2014","journal-title":"Elife"},{"issue":"Pt 1","key":"10.1016\/j.phrs.2018.08.010_bib0225","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1242\/jcs.111211","article-title":"Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology","volume":"126","author":"Onoue","year":"2013","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.phrs.2018.08.010_bib0230","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31326","article-title":"Endosomal Rab cycles regulate Parkin-mediated mitophagy","volume":"7","author":"Yamano","year":"2018","journal-title":"Elife"},{"issue":"828","key":"10.1016\/j.phrs.2018.08.010_bib0235","article-title":"Increased Drp1-mediated mitochondrial fission promotes proliferation and collagen production by right ventricular fibroblasts in experimental pulmonary arterial hypertension","volume":"9","author":"Tian","year":"2018","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib0240","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.molcel.2011.08.045","article-title":"Fine-tuning of Drp1\/Fis1 availability by AKAP121\/Siah2 regulates mitochondrial adaptation to hypoxia","volume":"44","author":"Kim","year":"2011","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib0245","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00109-017-1522-8","article-title":"Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension","volume":"95","author":"Tian","year":"2017","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.phrs.2018.08.010_bib0250","doi-asserted-by":"crossref","first-page":"32656","DOI":"10.1038\/srep32656","article-title":"Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson\u2019s disease model induced by MPTP","volume":"6","author":"Filichia","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0255","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/hmg\/ddr475","article-title":"Mutant huntingtin\u2019s interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington\u2019s disease","volume":"21","author":"Shirendeb","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.phrs.2018.08.010_bib0260","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","article-title":"Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington\u2019s disease: implications for selective neuronal damage","volume":"20","author":"Shirendeb","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"13","key":"10.1016\/j.phrs.2018.08.010_bib0265","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1093\/hmg\/ddr139","article-title":"Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer\u2019s disease: implications for neuronal damage","volume":"20","author":"Manczak","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib0270","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.18632\/oncotarget.23640","article-title":"Drp1\/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer\u2019s disease","volume":"9","author":"Joshi","year":"2018","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0275","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708166","article-title":"Inhibition of Drp1\/Fis1 interaction slows progression of amyotrophic lateral sclerosis","volume":"10","author":"Joshi","year":"2018","journal-title":"EMBO Mol. Med."},{"issue":"Pt 3","key":"10.1016\/j.phrs.2018.08.010_bib0280","first-page":"789","article-title":"A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity","volume":"126","author":"Qi","year":"2013","journal-title":"J. Cell. Sci."},{"issue":"12","key":"10.1016\/j.phrs.2018.08.010_bib0285","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1172\/JCI70911","article-title":"Inhibition of mitochondrial fragmentation diminishes Huntington\u2019s disease-associated neurodegeneration","volume":"123","author":"Guo","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0290","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1091\/mbc.e07-12-1287","article-title":"The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells","volume":"19","author":"Gandre-Babbe","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0295","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4161\/sgtp.2.3.16486","article-title":"Discovery of the membrane receptor for mitochondrial fission GTPase Drp1","volume":"2","author":"Otera","year":"2011","journal-title":"Small GTPases"},{"issue":"24","key":"10.1016\/j.phrs.2018.08.010_bib0300","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1091\/mbc.E15-08-0591","article-title":"The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1","volume":"26","author":"Liu","year":"2015","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0305","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/embor.2011.54","article-title":"MiD49 and MiD51, new components of the mitochondrial fission machinery","volume":"12","author":"Palmer","year":"2011","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib0310","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1083\/jcb.201508099","article-title":"Drp1-dependent mitochondrial fission via MiD49\/51 is essential for apoptotic cristae remodeling","volume":"212","author":"Otera","year":"2016","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0315","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.str.2014.01.001","article-title":"The mitochondrial fission receptor MiD51 requires ADP as a cofactor","volume":"22","author":"Loson","year":"2014","journal-title":"Structure"},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib0320","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1091\/mbc.e12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission","volume":"24","author":"Loson","year":"2013","journal-title":"Mol. Biol. Cell"},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0325","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1161\/CIRCULATIONAHA.117.031258","article-title":"Epigenetic dysregulation of the Drp1 binding partners MiD49 and MiD51 increases mitotic mitochondrial fission and promotes pulmonary arterial hypertension: mechanistic and therapeutic implications","volume":"138","author":"Chen","year":"2018","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0330","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41598-017-00853-x","article-title":"MIEF1\/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff","volume":"7","author":"Yu","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib0335","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1242\/jcs.185165","article-title":"Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission","volume":"129","author":"Osellame","year":"2016","journal-title":"J. Cell. Sci."},{"issue":"7","key":"10.1016\/j.phrs.2018.08.010_bib0340","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1083\/jcb.200407046","article-title":"Endophilin B1 is required for the maintenance of mitochondrial morphology","volume":"166","author":"Karbowski","year":"2004","journal-title":"J. Cell Biol."},{"issue":"21","key":"10.1016\/j.phrs.2018.08.010_bib0345","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.1128\/MCB.25.21.9369-9382.2005","article-title":"Loss of Bif-1 suppresses Bax\/Bak conformational change and mitochondrial apoptosis","volume":"25","author":"Takahashi","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"Pt. 14","key":"10.1016\/j.phrs.2018.08.010_bib0350","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1242\/jcs.02415","article-title":"The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells","volume":"118","author":"Tondera","year":"2005","journal-title":"J. Cell. Sci."},{"issue":"30","key":"10.1016\/j.phrs.2018.08.010_bib0355","doi-asserted-by":"crossref","first-page":"31544","DOI":"10.1074\/jbc.M404704200","article-title":"Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis","volume":"279","author":"Tondera","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005115","article-title":"Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy","volume":"11","author":"Barneo-Munoz","year":"2015","journal-title":"PLoS Genet."},{"issue":"7","key":"10.1016\/j.phrs.2018.08.010_bib0365","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1083\/jcb.200507087","article-title":"Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease","volume":"170","author":"Niemann","year":"2005","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0370","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nbd.2009.09.011","article-title":"GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance","volume":"36","author":"Niemann","year":"2009","journal-title":"Neurobiol. Dis."},{"issue":"Pt 13","key":"10.1016\/j.phrs.2018.08.010_bib0375","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1242\/jcs.038513","article-title":"The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation","volume":"122","author":"Zhao","year":"2009","journal-title":"J. Cell. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0380","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0385","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/msj.20157","article-title":"Neuropathology of Alzheimer\u2019s disease","volume":"77","author":"Perl","year":"2010","journal-title":"Mt. Sinai J. Med."},{"issue":"2-3","key":"10.1016\/j.phrs.2018.08.010_bib0390","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbadis.2004.06.018","article-title":"Tau alteration and neuronal degeneration in tauopathies: mechanisms and models","volume":"1739","author":"Brandt","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0395","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1083\/jcb.200207030","article-title":"Mitochondrial targeting and a novel transmembrane arrest of Alzheimer\u2019s amyloid precursor protein impairs mitochondrial function in neuronal cells","volume":"161","author":"Anandatheerthavarada","year":"2003","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0400","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/alzrt74","article-title":"Mitochondrial dysfunction - the beginning of the end in Alzheimer\u2019s disease? Separate and synergistic modes of tau and amyloid-beta toxicity","volume":"3","author":"Eckert","year":"2011","journal-title":"Alzheimers Res. Ther."},{"issue":"Suppl 2","key":"10.1016\/j.phrs.2018.08.010_bib0405","doi-asserted-by":"crossref","first-page":"S401","DOI":"10.3233\/JAD-2010-100666","article-title":"A synergistic dysfunction of mitochondrial fission\/fusion dynamics and mitophagy in Alzheimer\u2019s disease","volume":"20","author":"Santos","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0410","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bbadis.2009.10.006","article-title":"Mitochondrial dysfunction is a trigger of Alzheimer\u2019s disease pathophysiology","volume":"1802","author":"Moreira","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.phrs.2018.08.010_bib0415","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1111\/j.1582-4934.2009.00892.x","article-title":"Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis","volume":"13","author":"Pavlov","year":"2009","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0420","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbadis.2009.08.010","article-title":"Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases","volume":"1802","author":"Gibson","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"30","key":"10.1016\/j.phrs.2018.08.010_bib0425","doi-asserted-by":"crossref","first-page":"28294","DOI":"10.1074\/jbc.M212265200","article-title":"Neurotoxic mechanisms caused by the Alzheimer\u2019s disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway","volume":"278","author":"Marques","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0430","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032737","article-title":"Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer\u2019s disease","volume":"7","author":"Trushina","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib0435","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/WNR.0000000000000739","article-title":"Mitochondrial dynamics changes with age in an APPsw\/PS1dE9 mouse model of Alzheimer\u2019s disease","volume":"28","author":"Xu","year":"2017","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0440","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phrs.2018.08.010_bib0445","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E: far more than a lipid transport protein","volume":"1","author":"Mahley","year":"2000","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"issue":"10","key":"10.1016\/j.phrs.2018.08.010_bib0450","doi-asserted-by":"crossref","first-page":"e413","DOI":"10.1097\/RLU.0000000000000547","article-title":"Brain PET in the diagnosis of Alzheimer\u2019s disease","volume":"39","author":"Marcus","year":"2014","journal-title":"Clin. Nucl. Med."},{"issue":"7","key":"10.1016\/j.phrs.2018.08.010_bib0455","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1074\/jbc.M110.151084","article-title":"Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease","volume":"286","author":"Chen","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.phrs.2018.08.010_bib0460","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1523\/JNEUROSCI.19-12-04867.1999","article-title":"Expression of human apolipoprotein E3 or E4 in the brains of Apoe-\/- mice: isoform-specific effects on neurodegeneration","volume":"19","author":"Buttini","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2018.08.010_bib0465","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1750-1326-4-35","article-title":"Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells","volume":"4","author":"Nakamura","year":"2009","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0470","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/exnr.2000.7333","article-title":"Abnormal mitochondrial morphology in sporadic Parkinson\u2019s and Alzheimer\u2019s disease cybrid cell lines","volume":"162","author":"Trimmer","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2018.08.010_bib0475","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/B978-0-12-394816-8.00003-9","article-title":"Mitochondrial abnormalities in Alzheimer\u2019s disease: possible targets for therapeutic intervention","volume":"64","author":"Silva","year":"2012","journal-title":"Adv. Pharmacol."},{"issue":"23","key":"10.1016\/j.phrs.2018.08.010_bib0480","first-page":"5148","article-title":"Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer\u2019s disease","volume":"25","author":"Manczak","year":"2016","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib0485","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/j.bbamcr.2016.09.003","article-title":"Abeta-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis","volume":"1863","author":"Kim","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0490","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neurobiolaging.2014.08.005","article-title":"Blockage of GSK3beta-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer\u2019s disease","volume":"36","author":"Yan","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"5923","key":"10.1016\/j.phrs.2018.08.010_bib0495","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0500","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3233\/JAD-130275","article-title":"Abnormal interaction of oligomeric amyloid-beta with phosphorylated tau: implications to synaptic dysfunction and neuronal damage","volume":"36","author":"Manczak","year":"2013","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib0505","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1093\/hmg\/dds072","article-title":"Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer\u2019s disease neurons: implications for mitochondrial dysfunction and neuronal damage","volume":"21","author":"Manczak","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2018.08.010_bib0510","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fnins.2017.00553","article-title":"Mitochondrial bioenergetics is altered in fibroblasts from patients with sporadic alzheimer\u2019s disease","volume":"11","author":"Perez","year":"2017","journal-title":"Front. Neurosci."},{"issue":"20","key":"10.1016\/j.phrs.2018.08.010_bib0515","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1523\/JNEUROSCI.2385-16.2017","article-title":"Inhibition of Drp1 ameliorates synaptic depression, abeta deposition, and cognitive impairment in an Alzheimer\u2019s disease model","volume":"37","author":"Baek","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2018.08.010_bib0520","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4103\/2152-7806.169561","article-title":"A comprehensive review of amyotrophic lateral sclerosis","volume":"6","author":"Zarei","year":"2015","journal-title":"Surg. Neurol. Int."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0525","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/WCO.0b013e3283168d1d","article-title":"The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"21","author":"Mackenzie","year":"2008","journal-title":"Curr. Opin. Neurol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0530","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s13311-015-0338-x","article-title":"TDP-43 proteinopathy and ALS: insights into disease mechanisms and therapeutic targets","volume":"12","author":"Scotter","year":"2015","journal-title":"Neurotherapeutics."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0535","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1440-1789.2009.01089.x","article-title":"Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy","volume":"30","author":"Arai","year":"2010","journal-title":"Neuropathology"},{"issue":"8","key":"10.1016\/j.phrs.2018.08.010_bib0540","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1468-1331.2008.02195.x","article-title":"ALS and FTLD: two faces of TDP-43 proteinopathy","volume":"15","author":"Liscic","year":"2008","journal-title":"Eur. J. Neurol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0545","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mito.2005.01.002","article-title":"Mitochondrial dysfunction and its role in motor neuron degeneration in ALS","volume":"5","author":"Manfredi","year":"2005","journal-title":"Mitochondrion"},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0550","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/01913120252934260","article-title":"Ultrastructural changes of mitochondria in the skeletal muscle of patients with amyotrophic lateral sclerosis","volume":"26","author":"Chung","year":"2002","journal-title":"Ultrastruct. Pathol."},{"issue":"6415","key":"10.1016\/j.phrs.2018.08.010_bib0555","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"issue":"1-2","key":"10.1016\/j.phrs.2018.08.010_bib0560","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cell.2012.11.046","article-title":"SOD1 integrates signals from oxygen and glucose to repress respiration","volume":"152","author":"Reddi","year":"2013","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0565","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2174\/15672026113109990060","article-title":"Mitochondrial fusion and fission proteins expression dynamically change in a murine model of amyotrophic lateral sclerosis","volume":"10","author":"Liu","year":"2013","journal-title":"Curr. Neurovasc. Res."},{"issue":"12","key":"10.1016\/j.phrs.2018.08.010_bib0570","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082112","article-title":"Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model","volume":"8","author":"Luo","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0575","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/jnc.14327","article-title":"Pathomechanisms of TDP-43 in neurodegeneration","volume":"146","author":"Gao","year":"2018","journal-title":"J. Neurochem."},{"issue":"23","key":"10.1016\/j.phrs.2018.08.010_bib0580","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1093\/hmg\/ddt319","article-title":"The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons","volume":"22","author":"Wang","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"3-4","key":"10.1016\/j.phrs.2018.08.010_bib0585","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bbrc.2016.10.134","article-title":"Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis","volume":"481","author":"Altanbyek","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.phrs.2018.08.010_bib0590","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005357","article-title":"FUS interacts with HSP60 to promote mitochondrial damage","volume":"11","author":"Deng","year":"2015","journal-title":"PLoS Genet."},{"issue":"9","key":"10.1016\/j.phrs.2018.08.010_bib0595","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.15252\/embr.201541726","article-title":"ALS\/FTD-associated FUS activates GSK-3beta to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations","volume":"17","author":"Stoica","year":"2016","journal-title":"EMBO Rep."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0600","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrn3156","article-title":"Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration","volume":"13","author":"Sheng","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0605","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/nen.0b013e31802c396b","article-title":"Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis","volume":"66","author":"Sasaki","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"22","key":"10.1016\/j.phrs.2018.08.010_bib0610","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1093\/hmg\/ddm226","article-title":"Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content","volume":"16","author":"De Vos","year":"2007","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0615","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/hmg\/ddt528","article-title":"Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models","volume":"23","author":"Magrane","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0620","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12035-013-8427-5","article-title":"Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice","volume":"48","author":"Janssens","year":"2013","journal-title":"Mol. Neurobiol."},{"issue":"23","key":"10.1016\/j.phrs.2018.08.010_bib0625","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1093\/hmg\/ddx348","article-title":"Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels","volume":"26","author":"Moller","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2018.08.010_bib0630","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.nbd.2017.02.004","article-title":"Neurobiology of axonal transport defects in motor neuron diseases: opportunities for translational research?","volume":"105","author":"De Vos","year":"2017","journal-title":"Neurobiol. Dis."},{"issue":"7","key":"10.1016\/j.phrs.2018.08.010_bib0635","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1083\/jcb.201312123","article-title":"Mitochondrial trafficking and anchoring in neurons: new insight and implications","volume":"204","author":"Sheng","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2018.08.010_bib0640","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3389\/fncel.2015.00336","article-title":"SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis","volume":"9","author":"Tafuri","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2018.08.010_bib0645","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nm.4130","article-title":"The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity","volume":"22","author":"Wang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2018.08.010_bib0650","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.nbd.2012.07.004","article-title":"Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1alpha","volume":"51","author":"Song","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"Pt 5","key":"10.1016\/j.phrs.2018.08.010_bib0655","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1093\/brain\/aww033","article-title":"NEK1 mutations in familial amyotrophic lateral sclerosis","volume":"139","author":"Brenner","year":"2016","journal-title":"Brain."},{"issue":"9","key":"10.1016\/j.phrs.2018.08.010_bib0660","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/ng.3626","article-title":"NEK1 variants confer susceptibility to amyotrophic lateral sclerosis","volume":"48","author":"Kenna","year":"2016","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0665","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ajhg.2010.12.004","article-title":"NEK1 mutations cause short-rib polydactyly syndrome type majewski","volume":"88","author":"Thiel","year":"2011","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0670","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4161\/cc.8.2.7551","article-title":"Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1","volume":"8","author":"Chen","year":"2009","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0675","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/hmg\/ddx393","article-title":"Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS","volume":"27","author":"Straub","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2018.08.010_bib0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2017.02.011","article-title":"CHCHD10 mutations in patients with amyotrophic lateral sclerosis in Mainland China","volume":"54","author":"Shen","year":"2017","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib0685","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1007\/s12035-016-9888-0","article-title":"Mutation screening of the CHCHD10 gene in chinese patients with amyotrophic lateral sclerosis","volume":"54","author":"Zhou","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.phrs.2018.08.010_bib0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2014.07.022","article-title":"Screening of CHCHD10 in a French cohort confirms the involvement of this gene in frontotemporal dementia with amyotrophic lateral sclerosis patients","volume":"35","author":"Chaussenot","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib0695","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/WCO.0000000000000367","article-title":"Amyotrophic lateral sclerosis: recent genetic highlights","volume":"29","author":"White","year":"2016","journal-title":"Curr. Opin. Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0700","doi-asserted-by":"crossref","first-page":"58","DOI":"10.15252\/emmm.201505496","article-title":"CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis","volume":"8","author":"Genin","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.phrs.2018.08.010_bib0705","doi-asserted-by":"crossref","first-page":"15558","DOI":"10.1038\/ncomms15558","article-title":"Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity","volume":"8","author":"Woo","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2018.08.010_bib0710","doi-asserted-by":"crossref","first-page":"15500","DOI":"10.1038\/ncomms15500","article-title":"Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c","volume":"8","author":"Meng","year":"2017","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0715","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1083\/jcb.201601061","article-title":"The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages","volume":"215","author":"Zhu","year":"2016","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0720","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13041-017-0287-x","article-title":"TBK1: a new player in ALS linking autophagy and neuroinflammation","volume":"10","author":"Oakes","year":"2017","journal-title":"Mol. Brain"},{"issue":"15","key":"10.1016\/j.phrs.2018.08.010_bib0725","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1073\/pnas.1523926113","article-title":"Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria","volume":"113","author":"Richter","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.08.010_bib0730","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/B978-0-12-394305-7.00005-7","article-title":"Cellular and molecular biology of optineurin","volume":"294","author":"Ying","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0735","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/15548627.2015.1009792","article-title":"Temporal dynamics of PARK2\/parkin and OPTN\/optineurin recruitment during the mitophagy of damaged mitochondria","volume":"11","author":"Wong","year":"2015","journal-title":"Autophagy."},{"issue":"42","key":"10.1016\/j.phrs.2018.08.010_bib0740","doi-asserted-by":"crossref","first-page":"E4439","DOI":"10.1073\/pnas.1405752111","article-title":"Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation","volume":"111","author":"Wong","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.08.010_bib0745","series-title":"Neurobiology of Huntington\u2019S Disease: Applications to Drug Discovery","article-title":"Huntington\u2019s disease: clinical features and routes to therapy","author":"Paulson","year":"2011"},{"key":"10.1016\/j.phrs.2018.08.010_bib0750","series-title":"Neurobiology of Huntington\u2019s Disease: Applications to Drug Discovery","article-title":"Huntington\u2019s disease pathogenesis: mechanisms and pathways","author":"La Spada","year":"2011"},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0755","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nm.2313","article-title":"Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity","volume":"17","author":"Song","year":"2011","journal-title":"Nat. Med."},{"issue":"20","key":"10.1016\/j.phrs.2018.08.010_bib0760","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1093\/hmg\/ddq306","article-title":"Mitochondrial loss, dysfunction and altered dynamics in Huntington\u2019s disease","volume":"19","author":"Kim","year":"2010","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib0765","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1016\/j.bbadis.2015.08.012","article-title":"HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons","volume":"1852","author":"Guedes-Dias","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib0770","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1089\/ars.2012.4928","article-title":"S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington\u2019s disease","volume":"19","author":"Haun","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"7","key":"10.1016\/j.phrs.2018.08.010_bib0775","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.drudis.2014.03.020","article-title":"Increased mitochondrial fission and neuronal dysfunction in Huntington\u2019s disease: implications for molecular inhibitors of excessive mitochondrial fission","volume":"19","author":"Reddy","year":"2014","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib0780","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1476-5381.2012.02203.x","article-title":"Autophagy, mitochondria and 3-nitropropionic acid joined in the same model","volume":"168","author":"Gonzalez-Polo","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0785","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/cdd.2009.22","article-title":"Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway","volume":"16","author":"Liot","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2018.08.010_bib0790","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fnmol.2017.00050","article-title":"Modeling human neurological and neurodegenerative diseases: from induced pluripotent stem cells to neuronal differentiation and its applications in Neurotrauma","volume":"10","author":"Bahmad","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"10","key":"10.1016\/j.phrs.2018.08.010_bib0795","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1007\/s12035-015-9601-8","article-title":"Induced pluripotent stem cells in Huntington\u2019s disease: disease modeling and the potential for cell-based therapy","volume":"53","author":"Liu","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"24","key":"10.1016\/j.phrs.2018.08.010_bib0800","doi-asserted-by":"crossref","first-page":"10045","DOI":"10.1073\/pnas.0610628104","article-title":"Huntingtin facilitates dynein\/dynactin-mediated vesicle transport","volume":"104","author":"Caviston","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"18","key":"10.1016\/j.phrs.2018.08.010_bib0805","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.1128\/MCB.24.18.8195-8209.2004","article-title":"Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro","volume":"24","author":"Trushina","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0810","doi-asserted-by":"crossref","first-page":"259","DOI":"10.31887\/DCNS.2004.6.3\/galexander","article-title":"Biology of Parkinson\u2019s disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder","volume":"6","author":"Alexander","year":"2004","journal-title":"Dialogues Clin. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2018.08.010_bib0815","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009258","article-title":"Parkinson\u2019s disease and parkinsonism: neuropathology","volume":"2","author":"Dickson","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.phrs.2018.08.010_bib0820","first-page":"93","article-title":"Genetic models of Parkinson\u2019s disease: mechanisms and therapies","volume":"60","author":"Whitworth","year":"2008","journal-title":"SEB Exp. Biol. Ser."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0825","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson\u2019s disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2018.08.010_bib0830","article-title":"Toxin-induced and genetic animal models of Parkinson\u2019s disease","volume":"2011","author":"Hisahara","year":"2010","journal-title":"Parkinsons Dis."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0835","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1602\/neurorx.2.3.484","article-title":"Toxin-induced models of Parkinson\u2019s disease","volume":"2","author":"Bove","year":"2005","journal-title":"NeuroRx"},{"issue":"19","key":"10.1016\/j.phrs.2018.08.010_bib0840","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1523\/JNEUROSCI.0984-06.2006","article-title":"Parkinson\u2019s disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled","volume":"26","author":"Keeney","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2018.08.010_bib0845","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuint.2016.10.001","article-title":"Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson\u2019s disease","volume":"101","author":"Bhattacharjee","year":"2016","journal-title":"Neurochem. Int."},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2018.08.010_bib0850","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/jnc.13731","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease","volume":"139","author":"Bose","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2018.08.010_bib0855","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40035-016-0060-6","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease","volume":"5","author":"Hu","year":"2016","journal-title":"Transl. Neurodegener."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0860","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0865","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neulet.2008.05.005","article-title":"Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells","volume":"439","author":"Shavali","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2018.08.010_bib0870","article-title":"alphaSynuclein and mitochondrial dysfunction: a pathogenic partnership in parkinson\u2019s disease?","volume":"2012","author":"Protter","year":"2012","journal-title":"Parkinsons Dis."},{"issue":"9","key":"10.1016\/j.phrs.2018.08.010_bib0875","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1093\/hmg\/dds003","article-title":"LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1","volume":"21","author":"Wang","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2018.08.010_bib0880","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.nbd.2015.02.031","article-title":"Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice","volume":"78","author":"Yue","year":"2015","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib0885","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1089\/ars.2016.6634","article-title":"The essential role of Drp1 and its regulation by S-nitrosylation of Parkin in dopaminergic neurodegeneration: implications for parkinson\u2019s disease","volume":"25","author":"Zhang","year":"2016","journal-title":"Antioxid. Redox Signal."},{"issue":"22","key":"10.1016\/j.phrs.2018.08.010_bib0890","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1093\/hmg\/ddt301","article-title":"Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation","volume":"22","author":"Su","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0895","doi-asserted-by":"crossref","first-page":"281","DOI":"10.31887\/DCNS.2009.11.3\/mbelanger","article-title":"The role of astroglia in neuroprotection","volume":"11","author":"Belanger","year":"2009","journal-title":"Dialogues Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0900","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bbadis.2015.11.014","article-title":"Reactive gliosis in the pathogenesis of CNS diseases","volume":"1862","author":"Pekny","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0905","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive astrocytes: production, function, and therapeutic potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"issue":"7638","key":"10.1016\/j.phrs.2018.08.010_bib0910","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0915","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0006-8993(03)02361-8","article-title":"Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains","volume":"971","author":"Nagele","year":"2003","journal-title":"Brain Res."},{"issue":"7","key":"10.1016\/j.phrs.2018.08.010_bib0920","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/glia.20967","article-title":"Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer\u2019s disease","volume":"58","author":"Olabarria","year":"2010","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib0925","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.neurobiolaging.2008.05.015","article-title":"Ageing Neuropathology Study G. Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain","volume":"31","author":"Simpson","year":"2010","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib0930","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/glia.21212","article-title":"Multiple cellular and molecular mechanisms are involved in human Abeta clearance by transplanted adult astrocytes","volume":"59","author":"Pihlaja","year":"2011","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib0935","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nm838","article-title":"Adult mouse astrocytes degrade amyloid-beta in vitro and in situ","volume":"9","author":"Wyss-Coray","year":"2003","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib0940","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neurobiolaging.2014.09.027","article-title":"Alzheimer\u2019s disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes","volume":"36","author":"Sekar","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib0945","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1042\/BST20140171","article-title":"The contribution of astrocytes to Alzheimer\u2019s disease","volume":"42","author":"Birch","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.phrs.2018.08.010_bib0950","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.arr.2014.07.004","article-title":"When astrocytes become harmful: functional and inflammatory responses that contribute to Alzheimer\u2019s disease","volume":"18","author":"Avila-Munoz","year":"2014","journal-title":"Ageing Res. Rev."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0955","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020628","article-title":"Astrocytes in neurodegenerative disease","volume":"7","author":"Phatnani","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"38","key":"10.1016\/j.phrs.2018.08.010_bib0960","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1523\/JNEUROSCI.1243-10.2010","article-title":"Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer\u2019s disease","volume":"30","author":"Jana","year":"2010","journal-title":"J. Neurosci."},{"issue":"5918","key":"10.1016\/j.phrs.2018.08.010_bib0965","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1169096","article-title":"Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice","volume":"323","author":"Kuchibhotla","year":"2009","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.phrs.2018.08.010_bib0970","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1523\/JNEUROSCI.5098-09.2010","article-title":"Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability","volume":"30","author":"Allaman","year":"2010","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib0975","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/glia.20924","article-title":"Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer\u2019s disease","volume":"58","author":"Mori","year":"2010","journal-title":"Glia"},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib0980","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1083\/jcb.200508072","article-title":"Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity","volume":"171","author":"Shin","year":"2005","journal-title":"J. Cell Biol."},{"issue":"34","key":"10.1016\/j.phrs.2018.08.010_bib0985","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.1523\/JNEUROSCI.0168-16.2016","article-title":"Mutant huntingtin impairs BDNF release from astrocytes by disrupting conversion of Rab3a-GTP into Rab3a-GDP","volume":"36","author":"Hong","year":"2016","journal-title":"J. Neurosci."},{"issue":"52","key":"10.1016\/j.phrs.2018.08.010_bib0990","doi-asserted-by":"crossref","first-page":"22480","DOI":"10.1073\/pnas.0911503106","article-title":"Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms","volume":"106","author":"Bradford","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"13","key":"10.1016\/j.phrs.2018.08.010_bib0995","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1523\/JNEUROSCI.0116-08.2008","article-title":"Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5\/RANTES) by astrocytes","volume":"28","author":"Chou","year":"2008","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1000","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ana.24428","article-title":"Aberrant astrocytes impair vascular reactivity in Huntington disease","volume":"78","author":"Hsiao","year":"2015","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","article-title":"Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse","volume":"89","author":"Zhang","year":"2016","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib1010","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tins.2017.04.001","article-title":"The role of astrocyte dysfunction in parkinson\u2019s disease pathogenesis","volume":"40","author":"Booth","year":"2017","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1015","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.nbd.2008.09.013","article-title":"DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone","volume":"33","author":"Mullett","year":"2009","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib1020","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s12031-013-9984-9","article-title":"Knocking out DJ-1 attenuates astrocytes neuroprotection against 6-hydroxydopamine toxicity","volume":"50","author":"Lev","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.phrs.2018.08.010_bib1025","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.nbd.2015.03.003","article-title":"Glia and alpha-synuclein in neurodegeneration: a complex interaction","volume":"85","author":"Bruck","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phrs.2018.08.010_bib1030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1756-6606-3-12","article-title":"Astrocytic expression of Parkinson\u2019s disease-related A53T alpha-synuclein causes neurodegeneration in mice","volume":"3","author":"Gu","year":"2010","journal-title":"Mol. Brain"},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1035","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: a disease of motor neurons and their nonneuronal neighbors","volume":"52","author":"Boillee","year":"2006","journal-title":"Neuron"},{"issue":"21","key":"10.1016\/j.phrs.2018.08.010_bib1040","doi-asserted-by":"crossref","first-page":"7594","DOI":"10.1073\/pnas.0802556105","article-title":"Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice","volume":"105","author":"Yamanaka","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1045","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.stemcr.2017.06.008","article-title":"Reactive astrocytes promote ALS-like degeneration and intracellular protein aggregation in human motor neurons by disrupting autophagy through TGF-beta1","volume":"9","author":"Tripathi","year":"2017","journal-title":"Stem Cell Reports"},{"issue":"8","key":"10.1016\/j.phrs.2018.08.010_bib1050","doi-asserted-by":"crossref","first-page":"E756","DOI":"10.1073\/pnas.1222361110","article-title":"Intricate interplay between astrocytes and motor neurons in ALS","volume":"110","author":"Phatnani","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1055","first-page":"48","article-title":"ALS associated mutant SOD1 impairs the motor neurons and astrocytes and wild type astrocyte secreted-factors reverse the impaired motor neurons","volume":"18","author":"Thangavelu","year":"2011","journal-title":"Ann. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib1060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nn2047","article-title":"Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis","volume":"11","author":"Yamanaka","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1065","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/hmg\/ddq463","article-title":"Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice","volume":"20","author":"Wang","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib1070","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/nn.2210","article-title":"Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease","volume":"11","author":"Lepore","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1075","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/glia.22350","article-title":"Microglia and neurodegeneration: the role of systemic inflammation","volume":"61","author":"Cunningham","year":"2013","journal-title":"Glia."},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib1080","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease","volume":"10","author":"Perry","year":"2014","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1085","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/0192623310387619","article-title":"Microglia: key innate immune cells of the brain","volume":"39","author":"Kofler","year":"2011","journal-title":"Toxicol. Pathol."},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib1090","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.biopsych.2017.10.007","article-title":"Microglia-mediated neuroprotection, TREM2, and alzheimer\u2019s disease: evidence from optical imaging","volume":"83","author":"Condello","year":"2018","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1095","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.trci.2016.05.001","article-title":"The roles of inflammation and immune mechanisms in Alzheimer\u2019s disease","volume":"2","author":"Van Eldik","year":"2016","journal-title":"Alzheimers Dement. (N Y)"},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib1100","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2017.07.023","article-title":"TREM2 maintains microglial metabolic fitness in Alzheimer\u2019s disease","volume":"170","author":"Ulland","year":"2017","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib1105","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1110","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease","volume":"217","author":"Hansen","year":"2018","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1115","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/jnen\/60.2.161","article-title":"Early and progressive accumulation of reactive microglia in the Huntington disease brain","volume":"60","author":"Sapp","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"Pt 7","key":"10.1016\/j.phrs.2018.08.010_bib1120","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awm044","article-title":"Microglial activation in presymptomatic Huntington\u2019s disease gene carriers","volume":"130","author":"Tai","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.phrs.2018.08.010_bib1125","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1742-2094-11-98","article-title":"Neuroinflammation and M2 microglia: the good, the bad, and the inflamed","volume":"11","author":"Cherry","year":"2014","journal-title":"J. Neuroinflamm."},{"issue":"16","key":"10.1016\/j.phrs.2018.08.010_bib1130","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1093\/hmg\/ddu151","article-title":"Inhibition of soluble tumor necrosis factor is therapeutic in Huntington\u2019s disease","volume":"23","author":"Hsiao","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2018.08.010_bib1135","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneuroim.2016.02.012","article-title":"Revelation of the IFNalpha, IL-10, IL-8 and IL-1beta as promising biomarkers reflecting immuno-pathological mechanisms in porcine Huntington\u2019s disease model","volume":"293","author":"Valekova","year":"2016","journal-title":"J. Neuroimmunol."},{"issue":"8","key":"10.1016\/j.phrs.2018.08.010_bib1140","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1084\/jem.20080178","article-title":"A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington\u2019s disease","volume":"205","author":"Bjorkqvist","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2018.08.010_bib1145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.coph.2015.09.008","article-title":"Disruption of immune cell function by mutant huntingtin in Huntington\u2019s disease pathogenesis","volume":"26","author":"Andre","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"issue":"10","key":"10.1016\/j.phrs.2018.08.010_bib1150","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1172\/JCI64565","article-title":"Mutant huntingtin fragmentation in immune cells tracks Huntington\u2019s disease progression","volume":"122","author":"Weiss","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.phrs.2018.08.010_bib1155","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1172\/JCI64484","article-title":"Mutant huntingtin impairs immune cell migration in Huntington disease","volume":"122","author":"Kwan","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib1160","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.02.015","article-title":"Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons","volume":"33","author":"Kraft","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phrs.2018.08.010_bib1165","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1038\/ncomms11758","article-title":"Human glia can both induce and rescue aspects of disease phenotype in Huntington disease","volume":"7","author":"Benraiss","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2018.08.010_bib1170","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fnmol.2016.00089","article-title":"Protective microglia and their regulation in Parkinson's disease","volume":"9","author":"Le","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.phrs.2018.08.010_bib1175","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fnagi.2017.00176","article-title":"Targeting microglial activation states as a therapeutic avenue in parkinson\u2019s disease","volume":"9","author":"Subramaniam","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"9","key":"10.1016\/j.phrs.2018.08.010_bib1180","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ng.642","article-title":"Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson\u2019s disease","volume":"42","author":"Hamza","year":"2010","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.phrs.2018.08.010_bib1185","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00702-010-0428-1","article-title":"Neuroinflammation is a key player in Parkinson\u2019s disease and a prime target for therapy","volume":"117","author":"Qian","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.phrs.2018.08.010_bib1190","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-2094-2-14","article-title":"Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition","volume":"2","author":"Croisier","year":"2005","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1195","doi-asserted-by":"crossref","first-page":"e8784","DOI":"10.1371\/journal.pone.0008784","article-title":"Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson\u2019s disease","volume":"5","author":"Sanchez-Guajardo","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1200","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/glia.10150","article-title":"Microglial activation by purines and pyrimidines","volume":"40","author":"Inoue","year":"2002","journal-title":"Glia"},{"issue":"1-2","key":"10.1016\/j.phrs.2018.08.010_bib1205","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11302-006-9043-x","article-title":"Purinergic modulation of microglial cell activation","volume":"3","author":"Sperlagh","year":"2007","journal-title":"Purinergic Signal."},{"issue":"4","key":"10.1016\/j.phrs.2018.08.010_bib1210","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/glia.20015","article-title":"Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure","volume":"46","author":"Barcia","year":"2004","journal-title":"Glia"},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib1215","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/glia.20690","article-title":"Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys","volume":"56","author":"Kanaan","year":"2008","journal-title":"Glia"},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib1220","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/ana.10728","article-title":"Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration","volume":"54","author":"McGeer","year":"2003","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1225","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/neur.1996.0020","article-title":"Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson\u2019s disease mice model","volume":"5","author":"Czlonkowska","year":"1996","journal-title":"Neurodegeneration"},{"key":"10.1016\/j.phrs.2018.08.010_bib1230","article-title":"Dynamic changes in the Nigrostriatal Pathway in the MPTP mouse model of parkinson\u2019s disease","volume":"2017","author":"Huang","year":"2017","journal-title":"Parkinsons Dis."},{"issue":"1-2","key":"10.1016\/j.phrs.2018.08.010_bib1235","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2008.08.003","article-title":"The effects of MPTP on the activation of microglia\/astrocytes and cytokine\/chemokine levels in different mice strains","volume":"204","author":"Yasuda","year":"2008","journal-title":"J. Neuroimmunol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1240","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2005.10.034","article-title":"Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys","volume":"197","author":"Miklossy","year":"2006","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.phrs.2018.08.010_bib1245","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1651","article-title":"Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation","volume":"13","author":"Kebir","year":"2007","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1250","first-page":"182","article-title":"Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease","volume":"119","author":"Brochard","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1255","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.devcel.2007.11.019","article-title":"Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax\/Bak-dependent mitochondrial outer membrane permeabilization","volume":"14","author":"Cassidy-Stone","year":"2008","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.phrs.2018.08.010_bib1260","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.235","article-title":"Mitochondrial fission - a drug target for cytoprotection or cytodestruction?","volume":"4","author":"Rosdah","year":"2016","journal-title":"Pharmacol. Res. Perspect."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1265","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s12035-014-9002-4","article-title":"Mdivi-1 protects against ischemic brain injury via elevating extracellular adenosine in a cAMP\/CREB-CD39-Dependent manner","volume":"53","author":"Cui","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.phrs.2018.08.010_bib1270","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","article-title":"The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species","volume":"40","author":"Bordt","year":"2017","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1275","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbadis.2013.11.009","article-title":"Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer\u2019s disease cybrid cell","volume":"1842","author":"Gan","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"21","key":"10.1016\/j.phrs.2018.08.010_bib1280","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1093\/hmg\/ddx299","article-title":"Inhibition of mitochondrial fragmentation protects against Alzheimer\u2019s disease in rodent model","volume":"26","author":"Wang","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1285","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3233\/JAD-170051","article-title":"Mitochondria-division inhibitor 1 protects against amyloid-beta induced mitochondrial fragmentation and synaptic damage in Alzheimer\u2019s disease","volume":"58","author":"Reddy","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"15","key":"10.1016\/j.phrs.2018.08.010_bib1290","doi-asserted-by":"crossref","first-page":"11740","DOI":"10.1074\/jbc.M109.066662","article-title":"Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1","volume":"285","author":"Cui","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib1295","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/ALN.0000000000000857","article-title":"Altered mitochondrial dynamics contributes to propofol-induced cell death in human stem cell-derived neurons","volume":"123","author":"Twaroski","year":"2015","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1300","doi-asserted-by":"crossref","first-page":"7495","DOI":"10.1038\/s41598-017-07181-0","article-title":"Mitochondrial division inhibitor-1 is neuroprotective in the A53T-alpha-synuclein rat model of Parkinson\u2019s disease","volume":"7","author":"Bido","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2018.08.010_bib1305","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1038\/ncomms6244","article-title":"Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo","volume":"5","author":"Rappold","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2018.08.010_bib1310","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.320","article-title":"The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling","volume":"5","author":"Saez-Atienzar","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phrs.2018.08.010_bib1315","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bone.2017.10.010","article-title":"ALS-associated mutation SOD1(G93A) leads to abnormal mitochondrial dynamics in osteocytes","volume":"106","author":"Wang","year":"2018","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.phrs.2018.08.010_bib1320","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.3892\/ijo.2014.2608","article-title":"Mitochondrial division inhibitor-1 induces mitochondrial hyperfusion and sensitizes human cancer cells to TRAIL-induced apoptosis","volume":"45","author":"Akita","year":"2014","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1325","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bbrc.2014.11.010","article-title":"Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells","volume":"456","author":"Wang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2018.08.010_bib1330","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.redox.2013.10.011","article-title":"Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation","volume":"1","author":"Salabei","year":"2013","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.phrs.2018.08.010_bib1335","doi-asserted-by":"crossref","first-page":"R927","DOI":"10.1152\/ajpregu.00502.2012","article-title":"Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation","volume":"305","author":"Kim","year":"2013","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.phrs.2018.08.010_bib1340","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1262\/jrd.2014-070","article-title":"Mdivi-1, mitochondrial fission inhibitor, impairs developmental competence and mitochondrial function of embryos and cells in pigs","volume":"61","author":"Ji-Yeong","year":"2015","journal-title":"J. Reprod. Dev."},{"issue":"11","key":"10.1016\/j.phrs.2018.08.010_bib1345","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/CIRCRESAHA.116.305432","article-title":"Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases","volume":"116","author":"Kornfeld","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2018.08.010_bib1350","first-page":"789","article-title":"A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity","volume":"126","author":"Qi","year":"2013","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.phrs.2018.08.010_bib1355","first-page":"123","article-title":"Inhibition of mitochondrial fragmentation diminishes Huntington disease \u2013 associated neurodegeneration","author":"Guo","year":"2013","journal-title":"J Clin Invest."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818304675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818304675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:54:12Z","timestamp":1760910852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818304675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":271,"alternative-id":["S1043661818304675"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2018.08.010","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2018.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}