{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:41:08Z","timestamp":1792078868354,"version":"4.4.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health \u201cRicerca Finalizzata\u201d","award":["GR-2011-02351151"],"award-info":[{"award-number":["GR-2011-02351151"]}]},{"name":"Rita Levi Montalcini \u201cBrain Gain\u201d","award":["9795"],"award-info":[{"award-number":["9795"]}]},{"name":"Michael J. Fox RRIA 2014"},{"name":"PISCOPIA-MARIE CURIE"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.phrs.2018.09.006","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T18:33:06Z","timestamp":1536863586000},"page":"43-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":219,"special_numbering":"C","title":["Regulation of ER-mitochondria contacts by Parkin via Mfn2"],"prefix":"10.1016","volume":"138","author":[{"given":"Valentina","family":"Basso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Marchesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Peggion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"von Stockum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Giacomello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Ottolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Debattisti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Caicci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Tasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pegoraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Angelini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Bertoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Brini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ziviani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2018.09.006_bib0005","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1093\/hmg\/ddm159","article-title":"Parkinson\u2019s disease","volume":"16","author":"Thomas","year":"2007","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.phrs.2018.09.006_bib0010","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1601-183X.2007.00342.x","article-title":"Genetic findings in Parkinson\u2019s disease and translation into treatment: a leading role for mitochondria?","volume":"7","author":"Bogaerts","year":"2008","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.phrs.2018.09.006_bib0015","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/jemt.1070270303","article-title":"Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria","volume":"27","author":"Bereiter-Hahn","year":"1994","journal-title":"Microsc. Res. Technol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0020","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1242\/jcs.115.8.1663","article-title":"Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo","volume":"115","author":"Rojo","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phrs.2018.09.006_bib0025","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.151.2.341","article-title":"The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria","volume":"151","author":"Wong","year":"2000","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0030","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.09.006_bib0035","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/CIRCRESAHA.112.266585","article-title":"Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk","volume":"111","author":"Chen","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2018.09.006_bib0040","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature07534","article-title":"Mitofusin 2 tethers endoplasmic reticulum to mitochondria","volume":"456","author":"de Brito","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046293","article-title":"Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study","volume":"7","author":"Cosson","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.phrs.2018.09.006_bib0050","doi-asserted-by":"crossref","first-page":"E2174","DOI":"10.1073\/pnas.1504880112","article-title":"Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling","volume":"112","author":"Filadi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.09.006_bib0055","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nrm3440","article-title":"Endoplasmic reticulum-mitochondria contacts: function of the junction","volume":"13","author":"Rowland","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0060","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.280.5370.1763","article-title":"Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses","volume":"280","author":"Rizzuto","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.phrs.2018.09.006_bib0065","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1016\/S0021-9258(19)39106-9","article-title":"Phospholipid synthesis in a membrane fraction associated with mitochondria","volume":"265","author":"Vance","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2018.09.006_bib0070","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbadis.2013.01.004","article-title":"Enhanced Parkin levels favor ER-mitochondria crosstalk and guarantee Ca(2+) transfer to sustain cell bioenergetics","volume":"1832","author":"Cali","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2018.09.006_bib0075","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1093\/hmg\/ddt068","article-title":"The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering","volume":"22","author":"Ottolini","year":"2013","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.phrs.2018.09.006_bib0080","doi-asserted-by":"crossref","first-page":"17914","DOI":"10.1074\/jbc.M111.302794","article-title":"Alpha-synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions","volume":"287","author":"Cali","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2018.09.006_bib0085","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington\u2019s disease are a direct effect of polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2018.09.006_bib0090","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0095","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1073\/pnas.0913485107","article-title":"Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin","volume":"107","author":"Ziviani","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.09.006_bib0100","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1073\/pnas.0709336105","article-title":"The PINK1\/Parkin pathway regulates mitochondrial morphology","volume":"105","author":"Poole","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.09.006_bib0105","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0110","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1093\/hmg\/ddq419","article-title":"Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1\/Parkin-dependent manner upon induction of mitophagy","volume":"19","author":"Gegg","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.phrs.2018.09.006_bib0115","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04779","article-title":"Drosophila pink1 is required for mitochondrial function and interacts genetically with Parkin","volume":"441","author":"Clark","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0120","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nature04788","article-title":"Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by Parkin","volume":"441","author":"Park","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0125","doi-asserted-by":"crossref","first-page":"10793","DOI":"10.1073\/pnas.0602493103","article-title":"Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by parkin","volume":"103","author":"Yang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.09.006_bib0130","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1523\/JNEUROSCI.0719-07.2007","article-title":"Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by Parkin","volume":"27","author":"Exner","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2018.09.006_bib0135","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.molcel.2012.12.003","article-title":"Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways","volume":"49","author":"Anton","year":"2013","journal-title":"Mol. Cell."},{"key":"10.1016\/j.phrs.2018.09.006_bib0140","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1083\/jcb.201306121","article-title":"Reduction of endoplasmic reticulum stress attenuates the defects caused by drosophila mitofusin depletion","volume":"204","author":"Debattisti","year":"2014","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0145","doi-asserted-by":"crossref","first-page":"11249","DOI":"10.1073\/pnas.1606786113","article-title":"Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether","volume":"113","author":"Naon","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.09.006_bib0150","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cell.2011.02.010","article-title":"PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson\u2019s disease","volume":"144","author":"Shin","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2018.09.006_bib0155","doi-asserted-by":"crossref","first-page":"10744","DOI":"10.1073\/pnas.0401297101","article-title":"Loss of locus coeruleus neurons and reduced startle in parkin null mice","volume":"101","author":"Von Coelln","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.09.006_bib0160","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A","volume":"36","author":"Zuchner","year":"2004","journal-title":"Nat. Genet"},{"key":"10.1016\/j.phrs.2018.09.006_bib0165","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0170","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1083\/jcb.201611194","article-title":"A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space","volume":"217","author":"Mattie","year":"2018","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0175","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1091\/mbc.e08-02-0227","article-title":"Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion","volume":"19","author":"Cohen","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.phrs.2018.09.006_bib0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016746","article-title":"Mutations in PINK1 and Parkin impair ubiquitination of mitofusins in human fibroblasts","volume":"6","author":"Rakovic","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.phrs.2018.09.006_bib0185","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nature13418","article-title":"The mitochondrial deubiquitinase USP30 opposes Parkin-mediated mitophagy","volume":"510","author":"Bingol","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0190","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12043","article-title":"Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization","volume":"496","author":"Sarraf","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0195","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/02648725.2013.801232","article-title":"Proteomic identification of protein ubiquitination events","volume":"29","author":"Xu","year":"2013","journal-title":"Biotechnol. Genetic Eng. Rev."},{"key":"10.1016\/j.phrs.2018.09.006_bib0200","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tins.2016.01.008","article-title":"There\u2019s something wrong with my MAM; The ER-mitochondria axis and neurodegenerative diseases","volume":"39","author":"Paillusson","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2018.09.006_bib0205","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00401-015-1528-7","article-title":"Mitochondria-associated membranes as hubs for neurodegeneration","volume":"131","author":"Krols","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0210","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nature05865","article-title":"\u2019Rejuvenation\u2019 protects neurons in mouse models of Parkinson\u2019s disease","volume":"447","author":"Chan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0215","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.200604016","article-title":"Structural and functional features and significance of the physical linkage between ER and mitochondria","volume":"174","author":"Csordas","year":"2006","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0220","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molcel.2010.06.029","article-title":"Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface","volume":"39","author":"Csordas","year":"2010","journal-title":"Mol. Cell."},{"key":"10.1016\/j.phrs.2018.09.006_bib0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000298","article-title":"PINK1 is selectively stabilized on impaired mitochondria to activate Parkin","volume":"8","author":"Narendra","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0230","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1242\/jcs.078303","article-title":"Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance","volume":"124","author":"Heeman","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phrs.2018.09.006_bib0235","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1111\/j.1742-4658.2009.07201.x","article-title":"Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling","volume":"276","author":"Sandebring","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.phrs.2018.09.006_bib0240","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/nprot.2016.112","article-title":"A simple method for imaging axonal transport in aging neurons using the adult Drosophila wing","volume":"11","author":"Vagnoni","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phrs.2018.09.006_bib0245","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cmet.2014.12.007","article-title":"PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane","volume":"21","author":"Gehrke","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2018.09.006_bib0250","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.molcel.2013.01.036","article-title":"The E3 ligase Parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO","volume":"49","author":"Muller-Rischart","year":"2013","journal-title":"Mol. Cell."},{"key":"10.1016\/j.phrs.2018.09.006_bib0255","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1074\/jbc.M510393200","article-title":"Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro","volume":"281","author":"Matsuda","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2018.09.006_bib0260","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1093\/hmg\/ddl131","article-title":"Biochemical analysis of Parkinson\u2019s disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity","volume":"15","author":"Hampe","year":"2006","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.phrs.2018.09.006_bib0265","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1523\/JNEUROSCI.4474-04.2005","article-title":"Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation","volume":"25","author":"Lim","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2018.09.006_bib0270","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1471-4159.2011.07318.x","article-title":"Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1","volume":"118","author":"Glauser","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2018.09.006_bib0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010054","article-title":"The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1\/Parkin pathway","volume":"5","author":"Poole","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.phrs.2018.09.006_bib0280","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1523\/JNEUROSCI.5537-06.2007","article-title":"Parkin mediates neuroprotection through activation of IkappaB kinase\/nuclear factor-kappaB signaling","volume":"27","author":"Henn","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2018.09.006_bib0285","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ncb1441","article-title":"A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling","volume":"8","author":"Fallon","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0290","doi-asserted-by":"crossref","first-page":"16619","DOI":"10.1074\/jbc.M413591200","article-title":"Alpha-synuclein and Parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains","volume":"280","author":"Doss-Pepe","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2018.09.006_bib0295","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nrc2145","article-title":"Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation","volume":"7","author":"Salmena","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phrs.2018.09.006_bib0300","doi-asserted-by":"crossref","first-page":"R691","DOI":"10.1016\/j.cub.2013.07.039","article-title":"Structural biology: Parkin\u2019s serpentine shape revealed in the year of the snake","volume":"23","author":"Dove","year":"2013","journal-title":"Curr. Biol.: CB"},{"key":"10.1016\/j.phrs.2018.09.006_bib0305","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1038\/emboj.2013.125","article-title":"Structure of the human Parkin ligase domain in an autoinhibited state","volume":"32","author":"Wauer","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.phrs.2018.09.006_bib0310","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature11910","article-title":"Autophagosomes form at ER-mitochondria contact sites","volume":"495","author":"Hamasaki","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0315","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10230","article-title":"A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter","volume":"476","author":"De Stefani","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0320","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1207385","article-title":"ER tubules mark sites of mitochondrial division","volume":"334","author":"Friedman","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.phrs.2018.09.006_bib0325","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature02246","article-title":"The mitochondrial calcium uniporter is a highly selective ion channel","volume":"427","author":"Kirichok","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0330","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1089\/dna.2013.2011","article-title":"Calcium and endoplasmic reticulum-mitochondria tethering in neurodegeneration","volume":"32","author":"Cali","year":"2013","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0335","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.molcel.2009.02.013","article-title":"PINK1-associated Parkinson\u2019s disease is caused by neuronal vulnerability to calcium-induced cell death","volume":"33","author":"Gandhi","year":"2009","journal-title":"Mol. Cell."},{"key":"10.1016\/j.phrs.2018.09.006_bib0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037564","article-title":"Dopamine induced neurodegeneration in a PINK1 model of Parkinson\u2019s disease","volume":"7","author":"Gandhi","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.phrs.2018.09.006_bib0345","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1750-1326-7-22","article-title":"Regulation of mitochondrial permeability transition pore by PINK1","volume":"7","author":"Gautier","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.phrs.2018.09.006_bib0350","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1074\/jbc.270.17.9896","article-title":"Transfected aequorin in the measurement of cytosolic Ca2+ concentration ([Ca2+]c). A critical evaluation","volume":"270","author":"Brini","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2018.09.006_bib0355","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/358325a0","article-title":"Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin","volume":"358","author":"Rizzuto","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.09.006_bib0360","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/0006-291X(92)91309-E","article-title":"Engineering the CA(2+)-activated photoprotein aequorin with reduced affinity for calcium","volume":"187","author":"Kendall","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2018.09.006_bib0365","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2174\/1567205013666151116130104","article-title":"Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer\u2019s disease","volume":"13","author":"Lim","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.phrs.2018.09.006_bib0370","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/j.1471-4159.2010.07015.x","article-title":"Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons","volume":"116","author":"Lazzari","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2018.09.006_bib0375","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-0-12-801329-8.00002-7","article-title":"Methods to measure intracellular Ca(2+) fluxes with organelle-targeted aequorin-based probes","volume":"543","author":"Ottolini","year":"2014","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.phrs.2018.09.006_bib0380","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1002\/j.1460-2075.1995.tb00233.x","article-title":"Monitoring dynamic changes in free Ca2+ concentration in the endoplasmic reticulum of intact cells","volume":"14","author":"Montero","year":"1995","journal-title":"EMBO J."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818303219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818303219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T08:59:16Z","timestamp":1662022756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818303219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":76,"alternative-id":["S1043661818303219"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2018.09.006","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of ER-mitochondria contacts by Parkin via Mfn2","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2018.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}