{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:25:11Z","timestamp":1782311111131,"version":"3.54.5"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573667"],"award-info":[{"award-number":["81573667"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["020814380021"],"award-info":[{"award-number":["020814380021"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.phrs.2018.09.021","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T09:00:38Z","timestamp":1537606838000},"page":"64-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP\/NLRP3 inflammasome inhibition"],"prefix":"10.1016","volume":"137","author":[{"given":"Xiao-Qing","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Qing","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-9659","authenticated-orcid":false,"given":"Ting-Ting","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Dong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phrs.2018.09.021_bib0005","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrgastro.2010.41","article-title":"The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome","volume":"7","author":"Lim","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.phrs.2018.09.021_bib0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/s-2004-823104","article-title":"The pathogenesis of nonalcoholic steatohepatitis and other fatty liver diseases: a four-step model including the role of lipid release and hepatic venular obstruction in the progression to cirrhosis","volume":"24","author":"Wanless","year":"2004","journal-title":"Semin. Liver Dis."},{"issue":"5","key":"10.1016\/j.phrs.2018.09.021_bib0015","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.phrs.2018.09.021_bib0020","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ni.2228","article-title":"A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?","volume":"13","author":"Wen","year":"2012","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2018.09.021_bib0025","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bcp.2012.10.014","article-title":"Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-delta agonism correlates with impaired NLRP3 inflammasome activation","volume":"85","author":"Collino","year":"2013","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.phrs.2018.09.021_bib0030","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1089\/ars.2014.5868","article-title":"Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation","volume":"22","author":"Zhang","year":"2015","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.phrs.2018.09.021_bib0035","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phrs.2018.09.021_bib0040","doi-asserted-by":"crossref","first-page":"28734","DOI":"10.1038\/srep28734","article-title":"New insights into salvianolic acid A action: regulation of the TXNIP\/NLRP3 and TXNIP\/ChREBP pathways ameliorates HFD-induced NAFLD in rats","volume":"6","author":"Ding","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2018.09.021_bib0045","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.phrs.2018.09.021_bib0050","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrgastro.2013.87","article-title":"MicroRNAs in liver disease","volume":"10","author":"Szabo","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"9","key":"10.1016\/j.phrs.2018.09.021_bib0055","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/nm.3287","article-title":"Thioredoxin-interacting protein regulates insulin transcription through microRNA-204","volume":"19","author":"Xu","year":"2013","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.phrs.2018.09.021_bib0060","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.phrs.2018.09.021_bib0065","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.etp.2010.03.001","article-title":"Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property","volume":"63","author":"Naik","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"issue":"12","key":"10.1016\/j.phrs.2018.09.021_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015099","article-title":"Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation","volume":"5","author":"Bereswill","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.phrs.2018.09.021_bib0075","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1124\/mol.107.039818","article-title":"Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation","volume":"73","author":"Fu","year":"2008","journal-title":"Mol. Pharmacol."},{"issue":"11","key":"10.1016\/j.phrs.2018.09.021_bib0080","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1016\/j.fct.2010.08.034","article-title":"Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat","volume":"48","author":"Yousef","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.phrs.2018.09.021_bib0085","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1210\/en.2008-0262","article-title":"Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity","volume":"149","author":"Weisberg","year":"2008","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.phrs.2018.09.021_bib0090","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/hep.23524","article-title":"Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats","volume":"51","author":"Li","year":"2010","journal-title":"Hepatology"},{"issue":"48","key":"10.1016\/j.phrs.2018.09.021_bib0095","doi-asserted-by":"crossref","first-page":"40732","DOI":"10.1074\/jbc.M112.399899","article-title":"Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver","volume":"287","author":"Lanaspa","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.phrs.2018.09.021_bib0100","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: the ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.phrs.2018.09.021_bib0105","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","article-title":"Guidelines for reporting experiments involving animals: the ARRIVE guidelines","volume":"160","author":"McGrath","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.phrs.2018.09.021_bib0110","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1002\/mnfr.201500370","article-title":"Curcumin protects against fructose-induced podocyte insulin signaling impairment through upregulation of miR-206","volume":"59","author":"Ding","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phrs.2018.09.021_bib0115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.freeradbiomed.2015.02.029","article-title":"Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377","volume":"83","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.phrs.2018.09.021_bib0120","doi-asserted-by":"crossref","first-page":"G1044","DOI":"10.1152\/ajpgi.00297.2015","article-title":"microRNA-192 suppresses the expression of the farnesoid X receptor","volume":"310","author":"Krattinger","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"3","key":"10.1016\/j.phrs.2018.09.021_bib0125","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.phrs.2012.05.003","article-title":"Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats","volume":"66","author":"Bagul","year":"2012","journal-title":"Pharmacol. Res."},{"issue":"11","key":"10.1016\/j.phrs.2018.09.021_bib0130","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1073\/pnas.1119908109","article-title":"Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice","volume":"109","author":"Ishimoto","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.phrs.2018.09.021_bib0135","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jhep.2008.02.011","article-title":"Fructose consumption as a risk factor for non-alcoholic fatty liver disease","volume":"48","author":"Ouyang","year":"2008","journal-title":"J. Hepatol."},{"issue":"9","key":"10.1016\/j.phrs.2018.09.021_bib0140","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/mnfr.200700184","article-title":"Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db\/db mice","volume":"52","author":"Seo","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"issue":"11","key":"10.1016\/j.phrs.2018.09.021_bib0145","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/mnfr.201100080","article-title":"Curcumin attenuates diabetic nephropathy by inhibiting PKC-alpha and PKC-beta1 activity in streptozotocin-induced type I diabetic rats","volume":"55","author":"Soetikno","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"issue":"11","key":"10.1016\/j.phrs.2018.09.021_bib0150","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.metabol.2008.06.014","article-title":"Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters","volume":"57","author":"Jang","year":"2008","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.phrs.2018.09.021_bib0155","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.phrs.2018.09.021_bib0160","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/mnfr.201500316","article-title":"Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock","volume":"59","author":"Gong","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"issue":"8","key":"10.1016\/j.phrs.2018.09.021_bib0165","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.4049\/jimmunol.1701495","article-title":"Curcumin suppresses IL-1beta secretion and prevents inflammation through inhibition of the NLRP3 inflammasome","volume":"200","author":"Yin","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2018.09.021_bib0170","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3389\/fphar.2016.00369","article-title":"Curcumin represses NLRP3 inflammasome activation via TLR4\/MyD88\/NF-kappaB and P2X7R signaling in PMA-induced macrophages","volume":"7","author":"Kong","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2018.09.021_bib0175","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/161346","article-title":"Molecular mechanisms of curcumin on diabetes-induced endothelial dysfunctions: txnip, ICAM-1, and NOX2 expressions","volume":"2014","author":"Wongeakin","year":"2014","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.phrs.2018.09.021_bib0180","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.taap.2015.03.010","article-title":"Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP\/NLRP3 inflammasome activation in a manner dependent on AMPK","volume":"286","author":"Li","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2018.09.021_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2016.03.011","article-title":"Identification and differential expression of microRNAs associated with fat deposition in the liver of Wistar rats with nonalcoholic fatty liver disease","volume":"585","author":"Zhang","year":"2016","journal-title":"Gene"},{"issue":"11","key":"10.1016\/j.phrs.2018.09.021_bib0190","article-title":"Downregulation of miR-200a induces EMT phenotypes and CSC-like signatures through targeting the beta-catenin pathway in hepatic oval cells","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"issue":"1-2","key":"10.1016\/j.phrs.2018.09.021_bib0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11010-013-1895-0","article-title":"Participation of miR-200a in TGF-beta1-mediated hepatic stellate cell activation","volume":"388","author":"Sun","year":"2014","journal-title":"Mol. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.phrs.2018.09.021_bib0200","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s40291-016-0202-7","article-title":"Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases","volume":"20","author":"Momtazi","year":"2016","journal-title":"Mol. Diagn. Ther."},{"issue":"4","key":"10.1016\/j.phrs.2018.09.021_bib0205","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1002\/jcp.26055","article-title":"MicroRNA: a novel target of curcumin in cancer therapy","volume":"233","author":"Mirzaei","year":"2018","journal-title":"J. Cell Physiol."},{"issue":"7","key":"10.1016\/j.phrs.2018.09.021_bib0210","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1007\/s00125-016-3958-8","article-title":"C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21","volume":"59","author":"Wu","year":"2016","journal-title":"Diabetologia"},{"issue":"8","key":"10.1016\/j.phrs.2018.09.021_bib0215","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600760","article-title":"Fructose downregulates miR-330 to induce renal inflammatory response and insulin signaling impairment: attenuation by morin","volume":"61","author":"Gu","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.phrs.2018.09.021_bib0220","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbrc.2014.08.068","article-title":"Molecular mechanism of an adverse drug-drug interaction of allopurinol and furosemide in gout treatment","volume":"452","author":"Knake","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.phrs.2018.09.021_bib0225","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.18632\/aging.101250","article-title":"Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs","volume":"9","author":"McCubrey","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.phrs.2018.09.021_bib0230","series-title":"RNA Therapeutics","first-page":"79","article-title":"Approaches for the discovery of small molecule ligands targeting microRNAs","author":"Lorenz","year":"2008"},{"issue":"6","key":"10.1016\/j.phrs.2018.09.021_bib0235","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/clpt.2010.46","article-title":"Targeting microRNAs with small molecules: from dream to reality","volume":"87","author":"Zhang","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.phrs.2018.09.021_bib0240","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/nsmb.1673","article-title":"Structural insights into RNA processing by the human RISC-loading complex","volume":"16","author":"Wang","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2018.09.021_bib0245","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2011.10.003","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis","volume":"52","author":"Rolo","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.phrs.2018.09.021_bib0250","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/eji.200940168","article-title":"Signaling by ROS drives inflammasome activation","volume":"40","author":"Martinon","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phrs.2018.09.021_bib0255","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fphys.2013.00050","article-title":"TXNIP shuttling: missing link between oxidative stress and inflammasome activation","volume":"4","author":"Lane","year":"2013","journal-title":"Front. Physiol."},{"issue":"5","key":"10.1016\/j.phrs.2018.09.021_bib0260","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00395-014-0415-z","article-title":"TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia\/reperfusion injury","volume":"109","author":"Liu","year":"2014","journal-title":"Basic Res. Cardiol."},{"issue":"3","key":"10.1016\/j.phrs.2018.09.021_bib0265","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-079X.2012.00991.x","article-title":"Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway","volume":"53","author":"Lim","year":"2012","journal-title":"J. Pineal Res."},{"issue":"3","key":"10.1016\/j.phrs.2018.09.021_bib0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpj.2009.12.2031","article-title":"Mechanisms underlying fructose-induced oxidative stress in the cytosol and mitochondria","volume":"98","author":"Gaspers","year":"2010","journal-title":"Biophys. J."},{"issue":"10","key":"10.1016\/j.phrs.2018.09.021_bib0275","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/cdd.2011.42","article-title":"miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition","volume":"18","author":"Magenta","year":"2011","journal-title":"Cell Death Differ."},{"issue":"12","key":"10.1016\/j.phrs.2018.09.021_bib0280","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1038\/nm.2512","article-title":"miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response","volume":"17","author":"Mateescu","year":"2011","journal-title":"Nat. Med."},{"issue":"47","key":"10.1016\/j.phrs.2018.09.021_bib0285","doi-asserted-by":"crossref","first-page":"40725","DOI":"10.1074\/jbc.M111.275495","article-title":"miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells","volume":"286","author":"Eades","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.phrs.2018.09.021_bib0290","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1161\/01.RES.0000037982.55074.F6","article-title":"Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin","volume":"91","author":"Schulze","year":"2002","journal-title":"Circ. Res."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818308284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818308284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T04:19:03Z","timestamp":1589948343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818308284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":58,"alternative-id":["S1043661818308284"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2018.09.021","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP\/NLRP3 inflammasome inhibition","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2018.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}