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Neurosci."},{"key":"10.1016\/j.phrs.2018.11.012_bib0370","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainresbull.2012.09.015","article-title":"Effects of morphine withdrawal on the membrane properties of medium spiny neurons in the nucleus accumbens shell","volume":"90","author":"Wu","year":"2013","journal-title":"Brain Res. Bull."},{"issue":"6","key":"10.1016\/j.phrs.2018.11.012_bib0375","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/jnr.23025","article-title":"Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal","volume":"90","author":"Wu","year":"2012","journal-title":"J. Neurosci. Res."},{"issue":"5","key":"10.1016\/j.phrs.2018.11.012_bib0380","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuron.2010.08.012","article-title":"Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition","volume":"67","author":"Lu","year":"2010","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0385","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1124\/jpet.104.075184","article-title":"Repeated cocaine administration increases membrane excitability of pyramidal neurons in the rat medial prefrontal cortex","volume":"312","author":"Nasif","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"8","key":"10.1016\/j.phrs.2018.11.012_bib0390","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/sj.npp.1301577","article-title":"Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration","volume":"33","author":"Freeman","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0395","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1523\/JNEUROSCI.23-03-00742.2003","article-title":"Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving","volume":"23","author":"Grimm","year":"2003","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2018.11.012_bib0400","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1046\/j.1471-4159.2003.01824.x","article-title":"Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats","volume":"85","author":"Lu","year":"2003","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.phrs.2018.11.012_bib0405","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s002130100748","article-title":"Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats","volume":"156","author":"Shalev","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"issue":"7","key":"10.1016\/j.phrs.2018.11.012_bib0410","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/syn.20640","article-title":"Extended daily access to cocaine results in distinct alterations in Homer 1b\/c and NMDA receptor subunit expression within the medial prefrontal cortex","volume":"63","author":"Ben-Shahar","year":"2009","journal-title":"Synapse"},{"issue":"5","key":"10.1016\/j.phrs.2018.11.012_bib0415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037541","article-title":"Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex","volume":"7","author":"Kroener","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.phrs.2018.11.012_bib0420","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0248-16.2016","article-title":"Increased synaptic excitation and abnormal dendritic structure of prefrontal cortex layer V pyramidal neurons following prolonged binge-like consumption of ethanol","volume":"3","author":"Klenowski","year":"2016","journal-title":"eNeuro"},{"issue":"4","key":"10.1016\/j.phrs.2018.11.012_bib0425","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/j.1471-4159.2004.02392.x","article-title":"Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats","volume":"89","author":"Tang","year":"2004","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.phrs.2018.11.012_bib0430","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1460-9568.2010.07502.x","article-title":"Repeated exposure to morphine alters surface expression of AMPA receptors in the rat medial prefrontal cortex","volume":"33","author":"Mickiewicz","year":"2011","journal-title":"Eur. J. Neurosci."},{"issue":"9","key":"10.1016\/j.phrs.2018.11.012_bib0435","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/nn.2165","article-title":"Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking","volume":"11","author":"Van den Oever","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"1-2","key":"10.1016\/j.phrs.2018.11.012_bib0440","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cell.2015.11.038","article-title":"Prefrontal Parvalbumin Neurons in Control of Attention","volume":"164","author":"Kim","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2018.11.012_bib0445","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fnsys.2014.00230","article-title":"Optogenetic dissection of medial prefrontal cortex circuitry","volume":"8","author":"Riga","year":"2014","journal-title":"Front. Syst. Neurosci."},{"issue":"10","key":"10.1016\/j.phrs.2018.11.012_bib0450","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1523\/JNEUROSCI.0235-13.2014","article-title":"Activation of prefrontal cortical parvalbumin interneurons facilitates extinction of reward-seeking behavior","volume":"34","author":"Sparta","year":"2014","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2018.11.012_bib0455","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"Kalivas","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"5445","key":"10.1016\/j.phrs.2018.11.012_bib0460","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1126\/science.286.5445.1745","article-title":"Building neural representations of habits","volume":"286","author":"Jog","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.phrs.2018.11.012_bib0465","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.neuro.25.112701.142937","article-title":"Learning and memory functions of the Basal Ganglia","volume":"25","author":"Packard","year":"2002","journal-title":"Annu. Rev. Neurosci."},{"issue":"31","key":"10.1016\/j.phrs.2018.11.012_bib0470","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1523\/JNEUROSCI.1554-07.2007","article-title":"The role of the dorsal striatum in reward and decision-making","volume":"27","author":"Balleine","year":"2007","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2018.11.012_bib0475","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neubiorev.2003.11.013","article-title":"The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration","volume":"27","author":"Porrino","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"14","key":"10.1016\/j.phrs.2018.11.012_bib0480","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1523\/JNEUROSCI.5578-03.2004","article-title":"Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains","volume":"24","author":"Porrino","year":"2004","journal-title":"J. Neurosci."},{"issue":"5986","key":"10.1016\/j.phrs.2018.11.012_bib0485","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.1187801","article-title":"Transition to addiction is associated with a persistent impairment in synaptic plasticity","volume":"328","author":"Kasanetz","year":"2010","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.phrs.2018.11.012_bib0490","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/13803395.2013.828022","article-title":"Impulsivity, cognitive function, and their relationship in heroin-dependent individuals","volume":"35","author":"Zeng","year":"2013","journal-title":"J. Clin. Exp. Neuropsychol."},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0495","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neulet.2005.03.053","article-title":"Neural activity associated with cognitive regulation in heroin users: A fMRI study","volume":"382","author":"Lee","year":"2005","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.phrs.2018.11.012_bib0500","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/13803395.2016.1156652","article-title":"The effects of heroin administration and drug cues on impulsivity","volume":"38","author":"Jones","year":"2016","journal-title":"J. Clin. Exp. Neuropsychol."},{"issue":"2","key":"10.1016\/j.phrs.2018.11.012_bib0505","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00213-011-2444-8","article-title":"Unidirectional relationship between heroin self-administration and impulsive decision-making in rats","volume":"219","author":"Schippers","year":"2012","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2018.11.012_bib0510","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3389\/fnhum.2017.00646","article-title":"Neural correlates of drug-related attentional Bias in heroin dependence","volume":"11","author":"Zhao","year":"2017","journal-title":"Front. Hum. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0515","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.biopsych.2007.07.011","article-title":"Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats","volume":"63","author":"Diergaarde","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0520","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.biopsych.2007.06.003","article-title":"The role of orbitofrontal cortex in drug addiction: a review of preclinical studies","volume":"63","author":"Schoenbaum","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.phrs.2018.11.012_bib0525","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jsat.2009.03.009","article-title":"Measures of cognitive functioning as predictors of treatment outcome for cocaine dependence","volume":"37","author":"Turner","year":"2009","journal-title":"J. Subst. Abuse Treat."},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2018.11.012_bib0530","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuropharm.2004.06.005","article-title":"Conditioned reinforcing properties of stimuli paired with self-administered cocaine, heroin or sucrose: implications for the persistence of addictive behaviour","volume":"47","author":"Di Ciano","year":"2004","journal-title":"Neuropharmacology"},{"issue":"23","key":"10.1016\/j.phrs.2018.11.012_bib0535","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1523\/JNEUROSCI.1045-08.2008","article-title":"Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats","volume":"28","author":"Peters","year":"2008","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.phrs.2018.11.012_bib0540","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1460-9568.2012.07991.x","article-title":"Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell","volume":"35","author":"LaLumiere","year":"2012","journal-title":"Eur. J. Neurosci."},{"issue":"1-2","key":"10.1016\/j.phrs.2018.11.012_bib0545","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00213-003-1393-2","article-title":"Brain circuitry and the reinstatement of cocaine-seeking behavior","volume":"168","author":"Kalivas","year":"2003","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2018.11.012_bib0550","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnbeh.2013.00213","article-title":"Optogenetic dissection of basolateral amygdala projections during cue-induced reinstatement of cocaine seeking","volume":"7","author":"Stefanik","year":"2013","journal-title":"Front. Behav. Neurosci."},{"issue":"11","key":"10.1016\/j.phrs.2018.11.012_bib0555","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1523\/JNEUROSCI.20-11-04320.2000","article-title":"Medial frontal cortex mediates perceptual attentional set shifting in the rat","volume":"20","author":"Birrell","year":"2000","journal-title":"J. Neurosci."},{"issue":"6569","key":"10.1016\/j.phrs.2018.11.012_bib0560","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/380069a0","article-title":"Dissociation in prefrontal cortex of affective and attentional shifts","volume":"380","author":"Dias","year":"1996","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2018.11.012_bib0565","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbr.2008.02.008","article-title":"Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure","volume":"190","author":"Floresco","year":"2008","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.phrs.2018.11.012_bib0570","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuron.2011.01.020","article-title":"Impulsivity, compulsivity, and top-down cognitive control","volume":"69","author":"Dalley","year":"2011","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0575","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.biopsych.2007.11.014","article-title":"Impulsivity, compulsivity, and habit: the role of orbitofrontal cortex revisited","volume":"63","author":"Torregrossa","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.phrs.2018.11.012_bib0580","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/npp.2009.93","article-title":"Cortico-Basal Ganglia reward network: microcircuitry","volume":"35","author":"Sesack","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.phrs.2018.11.012_bib0585","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2011.05.007","article-title":"Molecular substrates of action control in cortico-striatal circuits","volume":"95","author":"Shiflett","year":"2011","journal-title":"Prog. Neurobiol."},{"issue":"8","key":"10.1016\/j.phrs.2018.11.012_bib0590","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tins.2004.06.006","article-title":"Putting a spin on the dorsal\u2013ventral divide of the striatum","volume":"27","author":"Voorn","year":"2004","journal-title":"Trends Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0595","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1176\/jnp.9.3.354","article-title":"The accumbens: beyond the core-shell dichotomy","volume":"9","author":"Heimer","year":"1997","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.phrs.2018.11.012_bib0600","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1749-6632.1999.tb09280.x","article-title":"Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems","volume":"877","author":"Everitt","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2018.11.012_bib0605","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0306-4522(91)90202-Y","article-title":"Specificity in the projection patterns of accumbal core and shell in the rat","volume":"41","author":"Heimer","year":"1991","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.phrs.2018.11.012_bib0610","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0306-4522(92)90202-D","article-title":"On the significance of subterritories in the \"accumbens\" part of the rat ventral striatum","volume":"50","author":"Zahm","year":"1992","journal-title":"Neuroscience"},{"issue":"5951","key":"10.1016\/j.phrs.2018.11.012_bib0615","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1126\/science.1174519","article-title":"Molecular and cellular approaches to memory allocation in neural circuits","volume":"326","author":"Silva","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.phrs.2018.11.012_bib0620","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1749-6632.2012.06768.x","article-title":"Associative learning mechanisms underpinning the transition from recreational drug use to addiction","volume":"1282","author":"Hogarth","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2018.11.012_bib0625","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nn1471","article-title":"Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior","volume":"8","author":"Goto","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"7501","key":"10.1016\/j.phrs.2018.11.012_bib0630","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nature13257","article-title":"Contrasting forms of cocaine-evoked plasticity control components of relapse","volume":"509","author":"Pascoli","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.phrs.2018.11.012_bib0635","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.conb.2013.01.026","article-title":"Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways)","volume":"23","author":"Smith","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0640","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/cne.903550308","article-title":"D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum","volume":"355","author":"Le Moine","year":"1995","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0645","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nn1654","article-title":"FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains","volume":"9","author":"Lobo","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"9","key":"10.1016\/j.phrs.2018.11.012_bib0650","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/nn.4068","article-title":"Coding the direct\/indirect pathways by D1 and D2 receptors is not valid for accumbens projections","volume":"18","author":"Kupchik","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"7","key":"10.1016\/j.phrs.2018.11.012_bib0655","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067219","article-title":"Evaluation of D1 and D2 dopamine receptor segregation in the developing striatum using BAC transgenic mice","volume":"8","author":"Thibault","year":"2013","journal-title":"PLoS One"},{"issue":"22","key":"10.1016\/j.phrs.2018.11.012_bib0660","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1523\/JNEUROSCI.1039-08.2008","article-title":"Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol","volume":"28","author":"Bertran-Gonzalez","year":"2008","journal-title":"J. Neurosci."},{"issue":"7379","key":"10.1016\/j.phrs.2018.11.012_bib0665","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nature10709","article-title":"Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour","volume":"481","author":"Pascoli","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0670","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1073\/pnas.1519248113","article-title":"Reversal of morphine-induced cell-type-specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement","volume":"113","author":"Hearing","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.phrs.2018.11.012_bib0675","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nn.4313","article-title":"Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses","volume":"19","author":"Graziane","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"7","key":"10.1016\/j.phrs.2018.11.012_bib0680","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/npp.2015.345","article-title":"Cell-type specific insertion of GluA2-Lacking AMPARs with cocaine exposure leading to sensitization, cue-induced seeking, and incubation of craving","volume":"41","author":"Terrier","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.phrs.2018.11.012_bib0685","doi-asserted-by":"crossref","first-page":"e4770","DOI":"10.1371\/journal.pone.0004770","article-title":"Striatal medium-sized spiny neurons: identification by nuclear staining and study of neuronal subpopulations in BAC transgenic mice","volume":"4","author":"Matamales","year":"2009","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.phrs.2018.11.012_bib0690","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tins.2009.06.005","article-title":"Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice","volume":"32","author":"Valjent","year":"2009","journal-title":"Trends Neurosci."},{"issue":"48","key":"10.1016\/j.phrs.2018.11.012_bib0695","doi-asserted-by":"crossref","first-page":"19407","DOI":"10.1073\/pnas.1112052108","article-title":"Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors","volume":"108","author":"Shen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.phrs.2018.11.012_bib0700","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.tins.2006.08.008","article-title":"Exciting inhibition in psychostimulant addiction","volume":"29","author":"Kalivas","year":"2006","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2018.11.012_bib0705","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2010.07.039","article-title":"Cocaine-induced homeostatic regulation and dysregulation of nucleus accumbens neurons","volume":"216","author":"Huang","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"18","key":"10.1016\/j.phrs.2018.11.012_bib0710","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1523\/JNEUROSCI.5703-08.2009","article-title":"Homeostatic synapse-driven membrane plasticity in nucleus accumbens neurons","volume":"29","author":"Ishikawa","year":"2009","journal-title":"J. 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Sci."},{"issue":"9","key":"10.1016\/j.phrs.2018.11.012_bib0750","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012088","article-title":"Glutamate mechanisms underlying opiate memories","volume":"2","author":"Peters","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"11","key":"10.1016\/j.phrs.2018.11.012_bib0755","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrn3104","article-title":"Opiate versus psychostimulant addiction: the differences do matter","volume":"12","author":"Badiani","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"issue":"21","key":"10.1016\/j.phrs.2018.11.012_bib0760","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1523\/JNEUROSCI.2875-12.2016","article-title":"Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats","volume":"36","author":"Russell","year":"2016","journal-title":"J. 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