{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:35:45Z","timestamp":1787114145807,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371798"],"award-info":[{"award-number":["81371798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.phrs.2018.11.036","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T12:03:39Z","timestamp":1543406619000},"page":"367-374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Use of oral contraceptives and risk of ulcerative colitis \u2013 A systematic review and meta-analysis"],"prefix":"10.1016","volume":"139","author":[{"given":"Xiaoyun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7413-080X","authenticated-orcid":false,"given":"Xiude","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"127","key":"10.1016\/j.phrs.2018.11.036_bib0005","first-page":"345","article-title":"A retrospective\u2009, case-control study on traditional environmental risk factors in inflammatory bowel disease in Vukovar-Srijem County, north-eastern Croatia","volume":"2015","author":"Vcev","year":"2010","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.phrs.2018.11.036_bib0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrgastro.2015.34","article-title":"Epidemiology and risk factors for IBD","volume":"12","author":"Ananthakrishnan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0020","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ng.764","article-title":"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47","volume":"43","author":"Anderson","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2018.11.036_bib0025","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2018.11.036_bib0030","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1111\/j.1572-0241.2008.02064.x","article-title":"The risk of oral contraceptives in the etiology of inflammatory bowel disease: a meta-analysis","volume":"103","author":"Cornish","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0035","first-page":"743","article-title":"Oral steroid contraception","volume":"11","author":"Sech","year":"2015","journal-title":"Women\u2019s Health"},{"key":"10.1016\/j.phrs.2018.11.036_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.beem.2012.11.004","article-title":"History of oral contraceptive drugs and their use worldwide","volume":"27","author":"Christin-Maitre","year":"2013","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2018.11.036_bib0045","first-page":"1","article-title":"Current contraceptive use in the United States, 2006-2010, and changes in patterns of use since 1995","volume":"60","author":"Jones","year":"2012","journal-title":"Health Stat. Report."},{"key":"10.1016\/j.phrs.2018.11.036_bib0050","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1136\/gut.37.5.668","article-title":"Meta-analysis of the role of oral contraceptive agents in inflammatory bowel disease","volume":"37","author":"Godet","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2018.11.036_bib0055","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0060","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1136\/bmj.316.7136.989","article-title":"When can odds ratios mislead?","volume":"316","author":"Davies","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2018.11.036_bib0065","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/j.1440-1746.2007.04873.x","article-title":"APDW 2004 Chinese IBD working group. Ulcerative colitis in China: retrospective analysis of 3100 hospitalized patients","volume":"22","author":"Wang","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0070","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2018.11.036_bib0075","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.phrs.2018.11.036_bib0080","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/ije\/dyn065","article-title":"Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation","volume":"37","author":"Patsopoulos","year":"2008","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0085","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2018.11.036_bib0090","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1136\/bmj.292.6528.1101","article-title":"Chronic inflammatory bowel disease, cigarette smoking, and use of oral contraceptives: findings in a large cohort study of women of childbearing age","volume":"292","author":"Vessey","year":"1986","journal-title":"Br. Med. J."},{"key":"10.1016\/j.phrs.2018.11.036_bib0095","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0016-5085(86)90611-6","article-title":"Inflammatory bowel disease in oral contraceptive users","volume":"91","author":"Calkins","year":"1986","journal-title":"Gastroenterology."},{"key":"10.1016\/j.phrs.2018.11.036_bib0100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/ije\/18.1.105","article-title":"Oral contraception, smoking and inflammatory bowel disease--findings in the Royal College of General Practitioners Oral Contraception Study","volume":"18","author":"Logan","year":"1989","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0105","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/0016-5085(90)90623-9","article-title":"Lack of association between oral contraceptive use and ulcerative colitis","volume":"99","author":"Lashner","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2018.11.036_bib0110","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/00001648-199207000-00014","article-title":"Oral contraceptive use and the risk of inflammatory bowel disease","volume":"3","author":"Sandler","year":"1992","journal-title":"Epidemiology"},{"key":"10.1016\/j.phrs.2018.11.036_bib0115","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/ije\/22.2.268","article-title":"Risk indicators for inflammatory bowel disease","volume":"22","author":"Persson","year":"1993","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0120","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/oxfordjournals.aje.a117246","article-title":"Increased risk of inflammatory bowel disease associated with oral contraceptive use","volume":"140","author":"Boyko","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0125","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/ije\/27.3.397","article-title":"Risk of inflammatory bowel disease attributable to smoking, oral contraception and breast feeding in Italy A nationwide case controlstudy","volume":"27","author":"Carrao","year":"1998","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0130","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2036.2005.02564.x","article-title":"Risk factors for inflammatory bowel disease in the general population","volume":"22","author":"Garc\u00eda Rodr\u00edguez","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2018.11.036_bib0135","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.3748\/wjg.v19.i11.1827","article-title":"Multicenter case-control study of the risk factors for ulcerative colitis in China","volume":"19","author":"Wang","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0140","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1136\/gutjnl-2012-302362","article-title":"Oral contraceptives, reproductive factors and risk of inflammatory bowel disease","volume":"62","author":"Khalili","year":"2013","journal-title":"Gut."},{"key":"10.1016\/j.phrs.2018.11.036_bib0145","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00508-015-0741-7","article-title":"A retrospective, case-control study on traditional environmental risk factors in inflammatory bowel disease in Vukovar-Srijem County, north-eastern Croatia","volume":"127","author":"Vcev","year":"2010","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.phrs.2018.11.036_bib0150","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.crohns.2014.02.002","article-title":"Smoking in inflammatory bowel disease: impact on disease course and insights into the aetiology of its effect","volume":"8","author":"Parkes","year":"2014","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.phrs.2018.11.036_bib0155","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1111\/j.1572-0241.2001.03944.x","article-title":"Impact of cessation of smoking on the course of ulcerative colitis","volume":"96","author":"Beaugerie","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0160","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/ibd.20884","article-title":"Effects of active and passive smoking on disease course of Crohn\u2019s disease and ulcerative colitis","volume":"15","author":"van der Heide","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.phrs.2018.11.036_bib0165","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ajg.2012.196","article-title":"A prospective study of cigarette smoking and the risk of inflammatory bowel disease in women","volume":"107","author":"Higuchi","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0170","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.4065\/81.11.1462","article-title":"Smoking and inflammatory bowel disease: a meta-analysis","volume":"81","author":"Mahid","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.phrs.2018.11.036_bib0175","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/BF01536701","article-title":"A meta-analysis of the role of smoking in inflammatory bowel disease","volume":"34","author":"Calkins","year":"1989","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.phrs.2018.11.036_bib0180","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2036.2005.02424.x","article-title":"Review article: smoking cessation as primary therapy to modify the course of Crohn\u2019s disease","volume":"21","author":"Johnson","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2018.11.036_bib0185","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetlycholine receptor \u03b17 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2018.11.036_bib0190","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1073\/pnas.0907697107","article-title":"Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats","volume":"107","author":"Braniste","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.11.036_bib0195","doi-asserted-by":"crossref","first-page":"G621","DOI":"10.1152\/ajpgi.00274.2010","article-title":"Estrogen receptor-\u03b2 signaling modulates epithelial barrier function","volume":"300","author":"Looijer-van Langen","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"Suppl. 3","key":"10.1016\/j.phrs.2018.11.036_bib0200","first-page":"iii2","article-title":"Oestrogens in rheumatic diseases: friend or foe?","volume":"47","author":"Cutolo","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.phrs.2018.11.036_bib0205","first-page":"339","article-title":"Environmental risk factors for inflammatory bowel disease","volume":"6","author":"Molodecky","year":"2010","journal-title":"Gastroenterol. Hepatol. (N. Y.)."},{"key":"10.1016\/j.phrs.2018.11.036_bib0210","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejogrb.2004.02.001","article-title":"Novel insight into the vaginal microflora in postmenopausal women under hormone replacement therapy as analyzed by PCR-denaturing gradient gel electrophoresis","volume":"117","author":"Devillard","year":"2004","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0215","first-page":"85","article-title":"Estrogen effects on the vaginal pH, flora and cytology in late postmenopause after a long period without hormone therapy","volume":"33","author":"Galhardo","year":"2006","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0220","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1139\/w05-070","article-title":"Vaginal microbial diversity among postmenopausal women with and without hormone replacement therapy","volume":"51","author":"Heinemann","year":"2005","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0225","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1902\/jop.2010.090575","article-title":"The impact of oral contraceptives on women\u2019s periodontal health and the subgingival occurrence of aggressive period on to pathogens and Candida species","volume":"81","author":"Brusca","year":"2010","journal-title":"J. Periodontol."},{"key":"10.1016\/j.phrs.2018.11.036_bib0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s40264-015-0372-y","article-title":"Risk of inflammatory bowel disease with oral contraceptives and menopausal HormoneTherapy: current evidence and future directions","volume":"39","author":"Khalili","year":"2016","journal-title":"Drug Saf."},{"key":"10.1016\/j.phrs.2018.11.036_bib0235","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1017\/S0033291700001732","article-title":"Publication bias and the integrity of psychiatry research","volume":"30","author":"Gilbody","year":"2000","journal-title":"Psychol. Med."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818317092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818317092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T07:41:28Z","timestamp":1565250088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818317092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":47,"alternative-id":["S1043661818317092"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2018.11.036","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of oral contraceptives and risk of ulcerative colitis \u2013 A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2018.11.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}