{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:24:45Z","timestamp":1772839485696,"version":"3.50.1"},"reference-count":227,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["- 2018R1A6A1A03025159"],"award-info":[{"award-number":["- 2018R1A6A1A03025159"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.phrs.2018.12.003","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T12:34:53Z","timestamp":1544531693000},"page":"1-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Research update and opportunity of non-hormonal male contraception: Histone demethylase KDM5B-based targeting"],"prefix":"10.1016","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5653-7347","authenticated-orcid":false,"given":"Sarder","family":"Arifuzzaman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Saidur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung-Geol","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2018.12.003_bib0005","unstructured":"World Population Prospects: The 2017 Revision. Department of Economic and Social Affairs, Population Division, United Nations, 2017; Key Findings and Advance Tables. ESA\/P\/WP\/248."},{"key":"10.1016\/j.phrs.2018.12.003_bib0010","series-title":"Department of Economic and Social Affairs Population Division, Fertility and Family Planning Section, United Nations","author":"WORLD CONTRACEPTIVE USE","year":"2018"},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0015","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.contraception.2010.03.016","article-title":"Acceptability of contraception for men: a review","volume":"82","author":"Glasier","year":"2010","journal-title":"Contraception"},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0020","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/humrep\/15.3.646","article-title":"Would women trust their partners to use a male pill?","volume":"15","author":"Glasier","year":"2000","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0010-7824(02)00360-8","article-title":"Migrant fathers and their attitudes to potential male hormonal contraceptives","volume":"66","author":"Weston","year":"2002","journal-title":"Contraception"},{"issue":"9520","key":"10.1016\/j.phrs.2018.12.003_bib0030","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/S0140-6736(06)68614-5","article-title":"Hormonal male contraception summit G. Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis","volume":"367","author":"Liu","year":"2006","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0035","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.contraception.2010.03.010","article-title":"Recent methodological advances in male hormonal contraception","volume":"82","author":"Liu","year":"2010","journal-title":"Contraception"},{"issue":"7","key":"10.1016\/j.phrs.2018.12.003_bib0040","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1210\/jc.2008-0265","article-title":"Male hormonal contraception: a double-blind, placebo-controlled study","volume":"93","author":"Mommers","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0045","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.contraception.2010.03.020","article-title":"Clinical trials in male hormonal contraception","volume":"82","author":"Nieschlag","year":"2010","journal-title":"Contraception"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0050","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1210\/jc.2008-1846","article-title":"Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men","volume":"94","author":"Gu","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0055","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1210\/jc.2002-020447","article-title":"A multicenter contraceptive efficacy study of injectable testosterone undecanoate in healthy Chinese men","volume":"88","author":"Gu","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0060","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.fertnstert.2016.08.036","article-title":"Male contraception","volume":"106","author":"Amory","year":"2016","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0065","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1210\/jc.2007-2768","article-title":"Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis","volume":"93","author":"Liu","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0070","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1177\/1557988315596361","article-title":"Male contraception: research, new methods, and implications for marginalized populations","volume":"11","author":"Plana","year":"2017","journal-title":"Am. J. Mens. Health"},{"issue":"10","key":"10.1016\/j.phrs.2018.12.003_bib0075","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrd1526","article-title":"Strategies to facilitate the development of new contraceptives","volume":"3","author":"Nass","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0080","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2164\/jandrol.110.010751","article-title":"Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis","volume":"32","author":"Amory","year":"2011","journal-title":"J. Androl."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0085","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1095\/biolreprod.106.059204","article-title":"Effects of CDB-4022 on leydig cell function in adult male rats","volume":"77","author":"Chen","year":"2007","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0090","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1021\/ml300365k","article-title":"Pharmacological activity of retinoic acid receptor alpha-selective antagonists in vitro and in vivo","volume":"4","author":"Chung","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0095","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1210\/en.2010-0941","article-title":"Oral administration of a retinoic acid receptor antagonist reversibly inhibits spermatogenesis in mice","volume":"152","author":"Chung","year":"2011","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0100","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1210\/en.2015-1675","article-title":"Prolonged oral administration of a pan-retinoic acid receptor antagonist inhibits spermatogenesis in mice with a rapid recovery and changes in the expression of influx and efflux transporters","volume":"157","author":"Chung","year":"2016","journal-title":"Endocrinology"},{"issue":"22","key":"10.1016\/j.phrs.2018.12.003_bib0105","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1002\/cmdc.201700503","article-title":"Potent pyrimidine and pyrrolopyrimidine inhibitors of testis-specific serine\/threonine kinase 2 (TSSK2)","volume":"12","author":"Hawkinson","year":"2017","journal-title":"ChemMedChem."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0110","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1210\/en.2006-1487","article-title":"Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis)","volume":"148","author":"Hild","year":"2007","journal-title":"Endocrinology."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0115","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0015-0282(16)59419-9","article-title":"Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study","volume":"48","author":"Liu","year":"1987","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0120","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0015-0282(16)59418-7","article-title":"Clinical trial of gossypol as a male contraceptive drug. Part I. Efficacy study","volume":"48","author":"Liu","year":"1987","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0125","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cell.2012.06.045","article-title":"Small-molecule inhibition of BRDT for male contraception","volume":"150","author":"Matzuk","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0130","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1530\/REP-10-0464","article-title":"Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes","volume":"141","author":"Mok","year":"2011","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0135","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tem.2007.11.002","article-title":"New perspectives in non-hormonal male contraception","volume":"19","author":"Mruk","year":"2008","journal-title":"Trends Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0140","doi-asserted-by":"crossref","first-page":"e0195953","DOI":"10.1371\/journal.pone.0195953","article-title":"Inhibition of sperm motility in male macaques with EP055, a potential non-hormonal male contraceptive","volume":"13","author":"O\u2019Rand","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0145","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bpobgyn.2014.05.008","article-title":"Male contraception","volume":"28","author":"Chao","year":"2014","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"6235","key":"10.1016\/j.phrs.2018.12.003_bib0150","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1126\/science.aaa0355","article-title":"Human genomics. The human transcriptome across tissues and individuals","volume":"348","author":"Mele","year":"2015","journal-title":"Science"},{"issue":"6220","key":"10.1016\/j.phrs.2018.12.003_bib0155","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"issue":"7527","key":"10.1016\/j.phrs.2018.12.003_bib0160","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature13992","article-title":"A comparative encyclopedia of DNA elements in the mouse genome","volume":"515","author":"Yue","year":"2014","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0165","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/molehr\/gau018","article-title":"The human testis-specific proteome defined by transcriptomics and antibody-based profiling","volume":"20","author":"Djureinovic","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.phrs.2018.12.003_bib0170","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.1126\/science.aal3321","article-title":"A subcellular map of the human proteome","volume":"356","author":"Thul","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.phrs.2018.12.003_bib0175","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bay002","article-title":"Worldwide protein data Bank biocuration supporting open access to high-quality 3D structural biology data","volume":"2018","author":"Young","year":"2018","journal-title":"Database (Oxford)"},{"issue":"18","key":"10.1016\/j.phrs.2018.12.003_bib0180","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/bioinformatics\/btv313","article-title":"DSigDB: drug signatures database for gene set analysis","volume":"31","author":"Yoo","year":"2015","journal-title":"Bioinformatics"},{"issue":"18","key":"10.1016\/j.phrs.2018.12.003_bib0185","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1021\/jm9006966","article-title":"Automated docking screens: a feasibility study","volume":"52","author":"Irwin","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phrs.2018.12.003_bib0190","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.pharmtox.41.1.101","article-title":"Pharmacogenomics: unlocking the human genome for better drug therapy","volume":"41","author":"McLeod","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib0195","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/01.ogx.0000182905.71077.13","article-title":"Nonhormonal drugs for contraception in men: a systematic review","volume":"60","author":"Lopez","year":"2005","journal-title":"Obstet. Gynecol. Surv."},{"issue":"6259","key":"10.1016\/j.phrs.2018.12.003_bib0200","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.aad0836","article-title":"Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive","volume":"350","author":"Miyata","year":"2015","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0205","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s11906-011-0184-0","article-title":"Metabolic syndrome, androgens, and hypertension","volume":"13","author":"Moulana","year":"2011","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.phrs.2018.12.003_bib0210","doi-asserted-by":"crossref","DOI":"10.1093\/humupd\/dmy021","article-title":"Epigenetic regulation in development: is the mouse a good model for the human?","author":"Hanna","year":"2018","journal-title":"Hum. Reprod. Update"},{"issue":"8","key":"10.1016\/j.phrs.2018.12.003_bib0215","doi-asserted-by":"crossref","first-page":"e72689","DOI":"10.1371\/journal.pone.0072689","article-title":"H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts","volume":"8","author":"Iwamori","year":"2013","journal-title":"PLoS One"},{"issue":"37","key":"10.1016\/j.phrs.2018.12.003_bib0220","doi-asserted-by":"crossref","first-page":"E5408","DOI":"10.1073\/pnas.1611995113","article-title":"MRG15 is required for pre-mRNA splicing and spermatogenesis","volume":"113","author":"Iwamori","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0225","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1095\/biolreprod.110.088955","article-title":"The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility","volume":"84","author":"Iwamori","year":"2011","journal-title":"Biol. Reprod."},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib0230","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1073\/pnas.0500702102","article-title":"Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis","volume":"102","author":"Webster","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.phrs.2018.12.003_bib0235","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1101\/gr.168801","article-title":"Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs","volume":"11","author":"Lahoud","year":"2001","journal-title":"Genome Res."},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib0240","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1096\/fj.14-267328","article-title":"The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors","volume":"29","author":"Lambrot","year":"2015","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0245","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1095\/biolreprod.115.135988","article-title":"The histone demethylase FBXL10 regulates the proliferation of spermatogonia and ensures long-term sustainable spermatogenesis in mice","volume":"94","author":"Ozawa","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.phrs.2018.12.003_bib0250","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13046-016-0311-5","article-title":"Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27","volume":"35","author":"Wang","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2018.12.003_bib0255","doi-asserted-by":"crossref","first-page":"21776","DOI":"10.1038\/srep21776","article-title":"Knockout of BRD7 results in impaired spermatogenesis and male infertility","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep."},{"issue":"7","key":"10.1016\/j.phrs.2018.12.003_bib0260","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nchembio.2087","article-title":"Structural analysis of human KDM5B guides histone demethylase inhibitor development","volume":"12","author":"Johansson","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"13","key":"10.1016\/j.phrs.2018.12.003_bib0265","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1074\/jbc.M112.419861","article-title":"Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen","volume":"288","author":"Sayegh","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2018.12.003_bib0270","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/1471-0528.12630","article-title":"Pregnancy and childbirth outcomes among adolescent mothers: a World Health Organization multicountry study","volume":"121","author":"Ganchimeg","year":"2014","journal-title":"BJOG"},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0275","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/jurban\/jth122","article-title":"Unintended pregnancy among the urban poor","volume":"81","author":"Besculides","year":"2004","journal-title":"J. Urban Health."},{"issue":"27","key":"10.1016\/j.phrs.2018.12.003_bib0280","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0968-8080(06)27233-1","article-title":"Addressing Japan\u2019s fertility decline: influences of unintended pregnancy on child rearing","volume":"14","author":"Goto","year":"2006","journal-title":"Reprod. Health Matters."},{"issue":"5 Suppl","key":"10.1016\/j.phrs.2018.12.003_bib0285","first-page":"27","article-title":"Complementary and alternative medicines: the herbal male contraceptives","volume":"8","author":"Lampiao","year":"2011","journal-title":"Afric. J. Tradit. Complement. Altern. Med."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0290","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/aja.2010.43","article-title":"Effects of plants and plant products on the testis","volume":"12","author":"D\u2019Cruz","year":"2010","journal-title":"Asian J. Androl."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0295","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1084\/jem.68.3.335","article-title":"Studies on the antigenic structure of some mammalian spermatozoa","volume":"68","author":"Henle","year":"1938","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0300","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/physrev.1948.28.2.180","article-title":"Fertilization and immunity","volume":"28","author":"Tyler","year":"1948","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0305","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1095\/biolreprod11.3.326","article-title":"Tests for rabbit sperm surface iron-binding protein and hyaluronidase using the \"exchange agglutination\" reaction","volume":"11","author":"O\u2019Rand","year":"1974","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0310","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0012-1606(77)90178-6","article-title":"Appearance of cell surface auto- and isoantigens during spermatogenesis in the rabbit","volume":"55","author":"O\u2019Rand","year":"1977","journal-title":"Dev. Biol."},{"key":"10.1016\/j.phrs.2018.12.003_bib0315","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/ajcp\/32.4.357","article-title":"Autoantibodies against spermatozoa in sterile men","volume":"32","author":"Rumke","year":"1959","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.phrs.2018.12.003_bib0320","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0070-2153(08)60595-5","article-title":"Sperm and egg receptors involved in fertilization","volume":"12","author":"Metz","year":"1978","journal-title":"Curr. Top Dev. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0325","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-0378(79)90030-5","article-title":"The effect on fertility of immunizing female sheep with ram sperm acrosin and hyaluronidase","volume":"1","author":"Morton","year":"1979","journal-title":"J. Reprod. Immunol."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0330","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1095\/biolreprod18.4.669","article-title":"Infertility in female rabbits isoimmunized with subcellular sperm fractions","volume":"18","author":"Munoz","year":"1978","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0335","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1439-0272.1976.tb02141.x","article-title":"Immunologic and testicular response in guinea pigs after unilateral traumatic orchitis","volume":"8","author":"Fainboim","year":"1976","journal-title":"Andrologia"},{"issue":"21","key":"10.1016\/j.phrs.2018.12.003_bib0340","doi-asserted-by":"crossref","DOI":"10.1021\/jm1012616","article-title":"Pharmacology. Principles and practice","volume":"53","author":"Cannon","year":"2010","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.phrs.2018.12.003_bib0345","doi-asserted-by":"crossref","first-page":"12201","DOI":"10.1073\/pnas.1635054100","article-title":"A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets","volume":"100","author":"Schultz","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0350","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1530\/REP-13-0603","article-title":"Identification of Leydig cell-specific mRNA transcripts in the adult rat testis","volume":"147","author":"O\u2019Shaughnessy","year":"2014","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0355","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cbpa.2008.01.022","article-title":"Proteomic methods for drug target discovery","volume":"12","author":"Sleno","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"6928","key":"10.1016\/j.phrs.2018.12.003_bib0360","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nature01511","article-title":"Mass spectrometry-based proteomics","volume":"422","author":"Aebersold","year":"2003","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.phrs.2018.12.003_bib0365","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0960-9822(02)70764-1","article-title":"Protein identification with sequence tags","volume":"6","author":"Wilkins","year":"1996","journal-title":"Curr. Biol."},{"issue":"12","key":"10.1016\/j.phrs.2018.12.003_bib0370","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/prca.200780120","article-title":"Analysis of the human testis proteome by mass spectrometry and bioinformatics","volume":"2","author":"Guo","year":"2008","journal-title":"Proteomics Clin. Appl."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0375","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1289\/EHP378","article-title":"Gestational exposure to bisphenol A affects the function and proteome profile of F1 spermatozoa in adult mice","volume":"125","author":"Rahman","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.phrs.2018.12.003_bib0380","doi-asserted-by":"crossref","first-page":"9169","DOI":"10.1038\/srep09169","article-title":"Bisphenol-A affects male fertility via fertility-related proteins in spermatozoa","volume":"5","author":"Rahman","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2018.12.003_bib0385","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1186\/s12864-016-2979-5","article-title":"A novel approach to assessing bisphenol-a hazards using an in vitro model system","volume":"17","author":"Rahman","year":"2016","journal-title":"BMC Genomics"},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib0390","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1002\/pmic.200700876","article-title":"The rat sperm proteome characterized via IPG strip prefractionation and LC-MS\/MS identification","volume":"8","author":"Baker","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.phrs.2018.12.003_bib0395","doi-asserted-by":"crossref","first-page":"13821","DOI":"10.1038\/srep13821","article-title":"Proteomic approaches for profiling negative fertility markers in inferior boar spermatozoa","volume":"5","author":"Kwon","year":"2015","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.phrs.2018.12.003_bib0400","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nrd2199","article-title":"How many drug targets are there?","volume":"5","author":"Overington","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phrs.2018.12.003_bib0405","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1196\/annals.1336.021","article-title":"Analysis of the human sperm proteome","volume":"1061","author":"Johnston","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"23","key":"10.1016\/j.phrs.2018.12.003_bib0410","doi-asserted-by":"crossref","first-page":"11162","DOI":"10.1073\/pnas.90.23.11162","article-title":"Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene","volume":"90","author":"Lubahn","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.phrs.2018.12.003_bib0415","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1073\/pnas.93.8.3264","article-title":"Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility","volume":"93","author":"Dix","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0420","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1101\/gad.10.1.80","article-title":"Abnormal spermatogenesis in RXR beta mutant mice","volume":"10","author":"Kastner","year":"1996","journal-title":"Genes Dev."},{"issue":"10","key":"10.1016\/j.phrs.2018.12.003_bib0425","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1101\/gad.10.10.1184","article-title":"The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis","volume":"10","author":"Sonnenberg-Riethmacher","year":"1996","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0430","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ando.2014.04.006","article-title":"Disrupting the male germ line to find infertility and contraception targets","volume":"75","author":"Archambeault","year":"2014","journal-title":"Ann. Endocrinol. (Paris)"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0435","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.scr.2013.05.012","article-title":"GASZ promotes germ cell derivation from embryonic stem cells","volume":"11","author":"Wang","year":"2013","journal-title":"Stem Cell Res."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0440","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.cell.2017.04.034","article-title":"Ubiquitination-deficient mutations in human piwi cause male infertility by impairing histone-to-protamine Exchange during spermiogenesis","volume":"169","author":"Gou","year":"2017","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0445","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/rda.12632","article-title":"VASA (DDX4) is a putative marker for spermatogonia, spermatocytes and round spermatids in stallions","volume":"50","author":"Kim","year":"2015","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.phrs.2018.12.003_bib0450","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1186\/1471-2164-12-591","article-title":"An exonic insertion within Tex14 gene causes spermatogenic arrest in pigs","volume":"12","author":"Sironen","year":"2011","journal-title":"BMC Genomics"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0455","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1073\/pnas.251686198","article-title":"The archetype STYX\/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production","volume":"99","author":"Wishart","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"28","key":"10.1016\/j.phrs.2018.12.003_bib0460","doi-asserted-by":"crossref","first-page":"7704","DOI":"10.1073\/pnas.1608458113","article-title":"Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice","volume":"113","author":"Miyata","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2018.12.003_bib0465","series-title":"Pharmacology: Principles and Practice","author":"Hacker","year":"2009"},{"issue":"9","key":"10.1016\/j.phrs.2018.12.003_bib0470","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1517\/17460441.2012.699036","article-title":"An update of novel screening methods for GPCR in drug discovery","volume":"7","author":"Chen","year":"2012","journal-title":"Expert Opin. Drug Discov."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0475","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.drudis.2013.06.003","article-title":"Genomics and transcriptomics in drug discovery","volume":"19","author":"Dopazo","year":"2014","journal-title":"Drug Discov Today"},{"issue":"W1","key":"10.1016\/j.phrs.2018.12.003_bib0480","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv352","article-title":"ChEMBL web services: streamlining access to drug discovery data and utilities","volume":"43","author":"Davies","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"Suppl 2","key":"10.1016\/j.phrs.2018.12.003_bib0485","first-page":"S4","article-title":"Phenotypic drug screening","volume":"19","author":"Enna","year":"2014","journal-title":"J. Peripher. Nerv. Syst."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0490","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0495","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.tibtech.2015.12.013","article-title":"Trans-omics: how to reconstruct biochemical networks across multiple\u2019 Omic\u2019 layers","volume":"34","author":"Yugi","year":"2016","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.phrs.2018.12.003_bib0500","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jpba.2014.12.020","article-title":"Emerging field of metabolomics: big promise for cancer biomarker identification and drug discovery","volume":"107","author":"Patel","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"12","key":"10.1016\/j.phrs.2018.12.003_bib0505","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nrg3796","article-title":"Unravelling the genomic targets of small molecules using high-throughput sequencing","volume":"15","author":"Rodriguez","year":"2014","journal-title":"Nat. Rev. Genet."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0510","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"6259","key":"10.1016\/j.phrs.2018.12.003_bib0515","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.aad4425","article-title":"Developmental biology. Toward a rapid and reversible male pill","volume":"350","author":"Castaneda","year":"2015","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib0520","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/nm.f.1895","article-title":"The biology of infertility: research advances and clinical challenges","volume":"14","author":"Matzuk","year":"2008","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0525","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0010-7824(02)00294-9","article-title":"Gossypol: a contraceptive for men","volume":"65","author":"Coutinho","year":"2002","journal-title":"Contraception"},{"issue":"4 Pt 2","key":"10.1016\/j.phrs.2018.12.003_bib0530","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0002-9378(87)80136-9","article-title":"Experiences with gossypol as a male pill","volume":"157","author":"Liu","year":"1987","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0535","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2605.1988.tb01211.x","article-title":"Recovery of sperm production following the cessation of gossypol treatment: a two-centre study in China","volume":"11","author":"Meng","year":"1988","journal-title":"Int. J. Androl."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0540","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1365-2605.1998.00092.x","article-title":"Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug","volume":"21","author":"Waites","year":"1998","journal-title":"Int. J. Androl."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0545","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0010-7824(87)90104-1","article-title":"Tripterygium wilfordii, a Chinese herb effective in male fertility regulation","volume":"36","author":"Qian","year":"1987","journal-title":"Contraception"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0550","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0010-7824(93)90036-7","article-title":"Male antifertility compounds from Tripterygium wilfordii Hook f","volume":"47","author":"Matlin","year":"1993","journal-title":"Contraception"},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0555","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/j.1939-4640.2000.tb02137.x","article-title":"Long-term effects of triptolide on spermatogenesis, epididymal sperm function, and fertility in male rats","volume":"21","author":"Huynh","year":"2000","journal-title":"J Androl."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0560","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/j.1939-4640.1998.tb02042.x","article-title":"Triptolide: a potential male contraceptive","volume":"19","author":"Lue","year":"1998","journal-title":"J. Androl."},{"issue":"7","key":"10.1016\/j.phrs.2018.12.003_bib0565","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2174\/0929867323666160112122724","article-title":"Effective delivery of male contraceptives behind the blood-testis barrier (BTB) - lesson from Adjudin","volume":"23","author":"Chen","year":"2016","journal-title":"Curr. Med. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0570","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1095\/biolreprod64.5.1500","article-title":"Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide","volume":"64","author":"Grima","year":"2001","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0575","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/humrep\/des384","article-title":"Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans","volume":"28","author":"Li","year":"2013","journal-title":"Hum. Reprod."},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib0580","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/nm1420","article-title":"A male contraceptive targeting germ cell adhesion","volume":"12","author":"Mruk","year":"2006","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0585","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1095\/biolreprod.106.057810","article-title":"A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose","volume":"78","author":"Tash","year":"2008","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0590","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1095\/biolreprod.103.026989","article-title":"The ability of a gonadotropin-releasing hormone antagonist, acyline, to prevent irreversible infertility induced by the indenopyridine, CDB-4022, in adult male rats: the role of testosterone","volume":"71","author":"Hild","year":"2004","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0595","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2164\/jandrol.106.002295","article-title":"Acute adverse effects of the indenopyridine CDB-4022 on the ultrastructure of sertoli cells, spermatocytes, and spermatids in rat testes: comparison to the known sertoli cell toxicant Di-n-pentylphthalate (DPP)","volume":"28","author":"Hild","year":"2007","journal-title":"J. Androl."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0600","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1095\/biolreprod65.6.1771","article-title":"Disruption of spermatogenesis and sertoli cell structure and function by the indenopyridine CDB-4022 in rats","volume":"65","author":"Hild","year":"2001","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0605","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1210\/en.2007-1332","article-title":"Mechanism of action of l-CDB-4022, a potential nonhormonal male contraceptive, in the seminiferous epithelium of the rat testis","volume":"149","author":"Koduri","year":"2008","journal-title":"Endocrinology"},{"issue":"39","key":"10.1016\/j.phrs.2018.12.003_bib0610","doi-asserted-by":"crossref","first-page":"64203","DOI":"10.18632\/oncotarget.11887","article-title":"F5-peptide induces aspermatogenesis by disrupting organization of actin- and microtubule-based cytoskeletons in the testis","volume":"7","author":"Gao","year":"2016","journal-title":"Oncotarget"},{"issue":"21","key":"10.1016\/j.phrs.2018.12.003_bib0615","doi-asserted-by":"crossref","first-page":"15104","DOI":"10.1074\/jbc.M113.540211","article-title":"Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice","volume":"289","author":"Paik","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0620","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/molehr\/gah052","article-title":"Expression analysis of the human testis-specific serine\/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm","volume":"10","author":"Hao","year":"2004","journal-title":"Mol. Hum. Reprod."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0625","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2164\/jandrol.109.008466","article-title":"Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment","volume":"31","author":"Zhang","year":"2010","journal-title":"J. Androl."},{"key":"10.1016\/j.phrs.2018.12.003_bib0630","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/B978-0-12-416024-8.00011-8","article-title":"The role of the double bromodomain-containing BET genes during mammalian spermatogenesis","volume":"102","author":"Berkovits","year":"2013","journal-title":"Curr. Top Dev. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0635","first-page":"659","article-title":"The role of human bromodomains in chromatin biology and gene transcription","volume":"12","author":"Sanchez","year":"2009","journal-title":"Curr. Opin. Drug Discov. Dev."},{"issue":"19","key":"10.1016\/j.phrs.2018.12.003_bib0640","doi-asserted-by":"crossref","first-page":"8642","DOI":"10.1128\/MCB.24.19.8642-8648.2004","article-title":"Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility","volume":"24","author":"Davies","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"1-2","key":"10.1016\/j.phrs.2018.12.003_bib0645","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.mce.2005.12.034","article-title":"Epididymal secreted protein Crisp-1 and sperm function","volume":"250","author":"Roberts","year":"2006","journal-title":"Mol. Cell Endocrinol."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0650","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1530\/REP-08-0132","article-title":"Novel epididymal proteins as targets for the development of post-testicular male contraception","volume":"137","author":"Sipila","year":"2009","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0655","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1530\/jrf.0.0580019","article-title":"Effect of local application of sympathomimetic drugs to the epididymis on fertility in rats","volume":"58","author":"Ratnasooriya","year":"1980","journal-title":"J. Reprod. Fertil."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0660","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0010-7824(90)90043-U","article-title":"Impairment of fertility of male rats with prazosin","volume":"41","author":"Ratnasooriya","year":"1990","journal-title":"Contraception"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0665","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1439-0272.1994.tb00766.x","article-title":"Tamsulosin, a selective alpha 1-adrenoceptor antagonist, inhibits fertility of male rats","volume":"26","author":"Ratnasooriya","year":"1994","journal-title":"Andrologia"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0670","doi-asserted-by":"crossref","first-page":"e66091","DOI":"10.1371\/journal.pone.0066091","article-title":"Slimmer or fertile? Pharmacological mechanisms involved in reduced sperm quality and fertility in rats exposed to the anorexigen sibutramine","volume":"8","author":"Borges","year":"2013","journal-title":"PLoS One"},{"issue":"5220","key":"10.1016\/j.phrs.2018.12.003_bib0675","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.7541556","article-title":"Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization","volume":"269","author":"Burks","year":"1995","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0680","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1152\/physrev.00028.2010","article-title":"Calcium channels in the development, maturation, and function of spermatozoa","volume":"91","author":"Darszon","year":"2011","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0685","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/oxfordjournals.humrep.a136023","article-title":"A positive correlation between expression of beta 1-integrin cell adhesion molecules and fertilizing ability of human spermatozoa in vitro","volume":"10","author":"Klentzeris","year":"1995","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0690","first-page":"456","article-title":"Integrin cell adhesion molecules on human spermatozoa","volume":"36","author":"Reddy","year":"1998","journal-title":"Indian J. Exp. Biol."},{"issue":"20","key":"10.1016\/j.phrs.2018.12.003_bib0695","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1056\/NEJMcibr1001843","article-title":"Sperm and the proton channel","volume":"362","author":"Ren","year":"2010","journal-title":"New Engl. J. Med."},{"issue":"6856","key":"10.1016\/j.phrs.2018.12.003_bib0700","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35098027","article-title":"A sperm ion channel required for sperm motility and male fertility","volume":"413","author":"Ren","year":"2001","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0705","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/molehr\/7.2.119","article-title":"Intracellular calcium store depletion and acrosome reaction in human spermatozoa: role of calcium and plasma membrane potential","volume":"7","author":"Rossato","year":"2001","journal-title":"Mol. Hum. Reprod."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0710","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0014-5793(92)80848-B","article-title":"The complete primary structure of the spermadhesin AWN, a zona pellucida-binding protein isolated from boar spermatozoa","volume":"300","author":"Sanz","year":"1992","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0715","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1439-0272.2001.00370.x","article-title":"Assessment of fibronectin as a potential new clinical tool in andrology","volume":"33","author":"Wennemuth","year":"2001","journal-title":"Andrologia"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0720","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2164\/jandrol.05009","article-title":"Sperm ion channels: molecular targets for the next generation of contraceptive medicines?","volume":"26","author":"Zhang","year":"2005","journal-title":"J. Androl."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0725","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1073\/pnas.1016902108","article-title":"K-ATPase alpha4 isoform is essential for sperm fertility","volume":"108","author":"Jimenez","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"22","key":"10.1016\/j.phrs.2018.12.003_bib0730","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1073\/pnas.1700367114","article-title":"Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids","volume":"114","author":"Mannowetz","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0735","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1095\/biolreprod.112.101832","article-title":"Characterization of EPPIN\u2019s semenogelin I binding site: a contraceptive drug target","volume":"87","author":"Silva","year":"2012","journal-title":"Biol. Reprod."},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib0740","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1172\/JCI29224","article-title":"Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility","volume":"116","author":"Yildiz","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"26","key":"10.1016\/j.phrs.2018.12.003_bib0745","doi-asserted-by":"crossref","first-page":"17173","DOI":"10.1073\/pnas.262586099","article-title":"Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception","volume":"99","author":"van der Spoel","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0750","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/humrep\/del414","article-title":"Miglustat has no apparent effect on spermatogenesis in normal men","volume":"22","author":"Amory","year":"2007","journal-title":"Hum. Reprod."},{"issue":"47","key":"10.1016\/j.phrs.2018.12.003_bib0755","doi-asserted-by":"crossref","first-page":"16501","DOI":"10.1073\/pnas.0407708101","article-title":"Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility","volume":"101","author":"Miki","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0760","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/molehr\/gaw016","article-title":"Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme","volume":"22","author":"Danshina","year":"2016","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.phrs.2018.12.003_bib0765","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1875397301105010030","article-title":"Development and implementation of a high throughput screen for the human sperm-specific isoform of glyceraldehyde 3-phosphate dehydrogenase (GAPDHS)","volume":"5","author":"Sexton","year":"2011","journal-title":"Curr Chem. Genom."},{"issue":"8","key":"10.1016\/j.phrs.2018.12.003_bib0770","doi-asserted-by":"crossref","first-page":"e43004","DOI":"10.1371\/journal.pone.0043004","article-title":"(S)-alpha-chlorohydrin inhibits protein tyrosine phosphorylation through blocking cyclic AMP - protein kinase a pathway in spermatozoa","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2018.12.003_bib0775","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-physiol-020911-153258","article-title":"The control of male fertility by spermatozoan ion channels","volume":"74","author":"Lishko","year":"2012","journal-title":"Annu. Rev. Physiol."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0780","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4103\/1117-1936.180807","article-title":"The effect of nifedipine on oral contraceptive-induced hypertension in rats","volume":"13","author":"Olatunji","year":"2006","journal-title":"Niger Postgrad. Med. J."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0785","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1530\/REP-17-0664","article-title":"Influence of antifertility agents dutasteride and nifedipine on CatSper gene level in epididymis during sperm maturation in BALB\/c mice","volume":"155","author":"Srivastav","year":"2018","journal-title":"Reproduction"},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib0790","doi-asserted-by":"crossref","first-page":"e2472","DOI":"10.1038\/cddis.2016.344","article-title":"The control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon\u2019s head to tail","volume":"7","author":"Chen","year":"2016","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0795","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1095\/biolreprod.106.054064","article-title":"The role of potassium chloride cotransporters in murine and human sperm volume regulation","volume":"75","author":"Klein","year":"2006","journal-title":"Biol. Reprod."},{"issue":"9","key":"10.1016\/j.phrs.2018.12.003_bib0800","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/molehr\/7.9.819","article-title":"Effects of the ion-channel blocker quinine on human sperm volume, kinematics and mucus penetration, and the involvement of potassium channels","volume":"7","author":"Yeung","year":"2001","journal-title":"Mol Hum Reprod."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0805","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/cm.20108","article-title":"Role of the Na+\/Ca2+ exchanger in calcium homeostasis and human sperm motility regulation","volume":"63","author":"Krasznai","year":"2006","journal-title":"Cell Motil. Cytoskeleton"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0810","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0010-7824(93)90082-I","article-title":"Phase I clinical trial of an injectable contraceptive for the male","volume":"48","author":"Guha","year":"1993","journal-title":"Contraception"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0815","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0010-7824(97)00142-X","article-title":"Phase II clinical trial of a vas deferens injectable contraceptive for the male","volume":"56","author":"Guha","year":"1997","journal-title":"Contraception"},{"issue":"8","key":"10.1016\/j.phrs.2018.12.003_bib0820","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/humrep\/deh332","article-title":"Studies on the membrane integrity of human sperm treated with a new injectable male contraceptive","volume":"19","author":"Chaudhury","year":"2004","journal-title":"Hum Reprod."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0825","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2007.01.033","article-title":"The mammalian epigenome","volume":"128","author":"Bernstein","year":"2007","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.phrs.2018.12.003_bib0830","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1093\/humrep\/der192","article-title":"Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men","volume":"26","author":"Hammoud","year":"2011","journal-title":"Hum Reprod."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0835","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.celrep.2017.01.034","article-title":"Chromatin states in mouse sperm correlate with embryonic and adult regulatory landscapes","volume":"18","author":"Jung","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2018.12.003_bib0840","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2051-4190-24-6","article-title":"Recent knowledge concerning mammalian sperm chromatin organization and its potential weaknesses when facing oxidative challenge","volume":"24","author":"Noblanc","year":"2014","journal-title":"Basic Clin. Androl."},{"key":"10.1016\/j.phrs.2018.12.003_bib0845","series-title":"Male Reproductive Health and Dysfunction","author":"Nieschlag","year":"2010"},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0850","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/aja.2010.65","article-title":"Proteomics and the genetics of sperm chromatin condensation","volume":"13","author":"Oliva","year":"2011","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.phrs.2018.12.003_bib0855","doi-asserted-by":"crossref","first-page":"360986","DOI":"10.1155\/2013\/360986","article-title":"Sperm proteomics: road to male fertility and contraception","volume":"2013","author":"Rahman","year":"2013","journal-title":"Int. J. Endocrinol."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0860","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2007.02.006","article-title":"Epigenetics: a landscape takes shape","volume":"128","author":"Goldberg","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0865","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1432-0436.1977.tb01508.x","article-title":"Histone synthesis and replacement during spermatogenesis in the mouse","volume":"7","author":"Goldberg","year":"1977","journal-title":"Differentiation"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0870","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.fertnstert.2014.04.025","article-title":"MicroRNAs and spermatogenesis","volume":"101","author":"Kotaja","year":"2014","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0875","doi-asserted-by":"crossref","DOI":"10.1530\/REP-14-0643","article-title":"MicroRNAs and DNA methylation as epigenetic regulators of mitosis, meiosis and spermiogenesis","volume":"150","author":"Yao","year":"2015","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0880","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1530\/REP-07-0576","article-title":"Epigenetic regulation in male germ cells","volume":"136","author":"Zamudio","year":"2008","journal-title":"Reproduction"},{"issue":"12","key":"10.1016\/j.phrs.2018.12.003_bib0885","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/humrep\/dex317","article-title":"Alterations in the sperm histone-retained epigenome are associated with unexplained male factor infertility and poor blastocyst development in donor oocyte IVF cycles","volume":"32","author":"Denomme","year":"2017","journal-title":"Hum Reprod."},{"key":"10.1016\/j.phrs.2018.12.003_bib0890","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1186\/s12864-015-1833-5","article-title":"DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis","volume":"16","author":"Kubo","year":"2015","journal-title":"BMC Genomics"},{"issue":"6314","key":"10.1016\/j.phrs.2018.12.003_bib0895","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1126\/science.aah5143","article-title":"The DNA methyltransferase DNMT3C protects male germ cells from transposon activity","volume":"354","author":"Barau","year":"2016","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib0900","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.rbmo.2016.08.022","article-title":"DNA methyltransferases exhibit dynamic expression during spermatogenesis","volume":"33","author":"Uysal","year":"2016","journal-title":"Reprod. Biomed. Online"},{"issue":"7143","key":"10.1016\/j.phrs.2018.12.003_bib0905","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature05915","article-title":"The complex language of chromatin regulation during transcription","volume":"447","author":"Berger","year":"2007","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0910","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/19396368.2016.1274791","article-title":"Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications","volume":"63","author":"Jenkins","year":"2017","journal-title":"Syst. Biol. Reprod. Med."},{"issue":"7","key":"10.1016\/j.phrs.2018.12.003_bib0915","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","article-title":"Histone demethylation mediated by the nuclear amine oxidase homolog LSD1","volume":"119","author":"Shi","year":"2004","journal-title":"Cell"},{"issue":"7078","key":"10.1016\/j.phrs.2018.12.003_bib0920","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature04433","article-title":"Histone demethylation by a family of JmjC domain-containing proteins","volume":"439","author":"Tsukada","year":"2006","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib0925","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1530\/REP-18-0009","article-title":"Epigenetic reprogramming during spermatogenesis and male factor infertility","volume":"156","author":"McSwiggin","year":"2018","journal-title":"Reproduction"},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0930","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbagrm.2013.08.004","article-title":"Chromatin dynamics during spermiogenesis","volume":"1839","author":"Rathke","year":"2014","journal-title":"Biochim. Biophys. Acta."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0935","doi-asserted-by":"crossref","first-page":"e0177473","DOI":"10.1371\/journal.pone.0177473","article-title":"KDM1A\/LSD1 regulates the differentiation and maintenance of spermatogonia in mice","volume":"12","author":"Myrick","year":"2017","journal-title":"PLoS One"},{"issue":"6261","key":"10.1016\/j.phrs.2018.12.003_bib0940","doi-asserted-by":"crossref","DOI":"10.1126\/science.aab2006","article-title":"Disruption of histone methylation in developing sperm impairs offspring health transgenerationally","volume":"350","author":"Siklenka","year":"2015","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0945","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.mcn.2011.01.001","article-title":"Fbxl10\/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly","volume":"46","author":"Fukuda","year":"2011","journal-title":"Mol. Cell Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0950","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/andr.12164","article-title":"Expression ratio of histone demethylase KDM3A to protamine-1 mRNA is predictive of successful testicular sperm extraction in men with obstructive and non-obstructive azoospermia","volume":"4","author":"Javadirad","year":"2016","journal-title":"Andrology"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib0955","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1095\/biolreprod.113.108597","article-title":"JMJD1C, A JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice","volume":"89","author":"Kuroki","year":"2013","journal-title":"Biol. Reprod."},{"issue":"7166","key":"10.1016\/j.phrs.2018.12.003_bib0960","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature06236","article-title":"Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis","volume":"450","author":"Okada","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib0965","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2164\/jandrol.109.008052","article-title":"Histone demethylase JHDM2A is involved in male infertility and obesity","volume":"31","author":"Okada","year":"2010","journal-title":"J. Androl."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib0970","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm3327","article-title":"Molecular mechanisms and potential functions of histone demethylases","volume":"13","author":"Kooistra","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib0975","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2217\/epi.14.14","article-title":"The KDM5 family of histone demethylases as targets in oncology drug discovery","volume":"6","author":"Rasmussen","year":"2014","journal-title":"Epigenomics"},{"key":"10.1016\/j.phrs.2018.12.003_bib0980","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.gene.2018.01.092","article-title":"Pig KDM5B: mRNA expression profiles of different tissues and testicular cells and association analyses with testicular morphology traits","volume":"650","author":"Cui","year":"2018","journal-title":"Gene"},{"issue":"25","key":"10.1016\/j.phrs.2018.12.003_bib0985","doi-asserted-by":"crossref","first-page":"17620","DOI":"10.1074\/jbc.M114.570853","article-title":"Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes","volume":"289","author":"Zou","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib0990","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/j.1742-4658.2012.08567.x","article-title":"Studies of H3K4me3 demethylation by KDM5B\/Jarid1B\/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor","volume":"279","author":"Kristensen","year":"2012","journal-title":"FEBS J."},{"issue":"16","key":"10.1016\/j.phrs.2018.12.003_bib0995","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1016\/j.bmcl.2016.06.078","article-title":"Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies","volume":"26","author":"Liang","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"7","key":"10.1016\/j.phrs.2018.12.003_bib1000","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nchembio.2085","article-title":"An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells","volume":"12","author":"Vinogradova","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib1005","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1021\/acs.jmedchem.5b01538","article-title":"Cell penetrant inhibitors of the KDM4 and KDM5 families of histone lysine demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one derivatives","volume":"59","author":"Westaway","year":"2016","journal-title":"J. Med. Chem."},{"issue":"7","key":"10.1016\/j.phrs.2018.12.003_bib1010","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.chembiol.2016.06.006","article-title":"Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds","volume":"23","author":"Horton","year":"2016","journal-title":"Cell Chem. Biol."},{"issue":"7","key":"10.1016\/j.phrs.2018.12.003_bib1015","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1161\/ATVBAHA.115.305561","article-title":"Epigenetic regulation of angiogenesis by JARID1B-induced repression of HOXA5","volume":"35","author":"Fork","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"22","key":"10.1016\/j.phrs.2018.12.003_bib1020","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1038\/emboj.2011.383","article-title":"Jarid1b targets genes regulating development and is involved in neural differentiation","volume":"30","author":"Schmitz","year":"2011","journal-title":"EMBO J."},{"issue":"13","key":"10.1016\/j.phrs.2018.12.003_bib1025","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1182\/blood-2014-08-596734","article-title":"The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice","volume":"125","author":"Stewart","year":"2015","journal-title":"Blood."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib1030","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1021\/acs.jmedchem.7b00925","article-title":"Synthesis, and in vitro and in vivo evaluation of ouabain analogues as potent and selective Na,K-ATPase alpha4 isoform inhibitors for male contraception","volume":"61","author":"Syeda","year":"2018","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib1035","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1095\/biolreprod46.5.869","article-title":"Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells","volume":"46","author":"Welch","year":"1992","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib1040","doi-asserted-by":"crossref","first-page":"e54192","DOI":"10.1371\/journal.pone.0054192","article-title":"Vasopressin effectively suppresses male fertility","volume":"8","author":"Kwon","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib1045","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.fertnstert.2012.09.021","article-title":"Voltage-dependent anion channels are a key factor of male fertility","volume":"99","author":"Kwon","year":"2013","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib1050","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/andr.12076","article-title":"Actin-related protein 2\/3 complex-based actin polymerization is critical for male fertility","volume":"3","author":"Lee","year":"2015","journal-title":"Andrology"},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib1055","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1530\/REP-14-0471","article-title":"ATPases, ion exchangers and human sperm motility","volume":"149","author":"Peralta-Arias","year":"2015","journal-title":"Reproduction"},{"issue":"11","key":"10.1016\/j.phrs.2018.12.003_bib1060","doi-asserted-by":"crossref","first-page":"e27127","DOI":"10.1371\/journal.pone.0027127","article-title":"Mll5 is required for normal spermatogenesis","volume":"6","author":"Yap","year":"2011","journal-title":"PLoS One"},{"issue":"7004","key":"10.1016\/j.phrs.2018.12.003_bib1065","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature02886","article-title":"Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L","volume":"431","author":"Bourc\u2019his","year":"2004","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.003_bib1070","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","article-title":"Targeted mutation of the DNA methyltransferase gene results in embryonic lethality","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib1075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1101\/gad.13.1.26","article-title":"Cytosine methylation and mammalian development","volume":"13","author":"Walsh","year":"1999","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib1080","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0092-8674(00)80199-3","article-title":"Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination","volume":"89","author":"Essers","year":"1997","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.phrs.2018.12.003_bib1085","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(01)00542-6","article-title":"Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability","volume":"107","author":"Peters","year":"2001","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.phrs.2018.12.003_bib1090","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1038\/sj.emboj.7601767","article-title":"Functional dynamics of H3K9 methylation during meiotic prophase progression","volume":"26","author":"Tachibana","year":"2007","journal-title":"EMBO J."},{"issue":"7066","key":"10.1016\/j.phrs.2018.12.003_bib1095","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nature04112","article-title":"A histone H3 methyltransferase controls epigenetic events required for meiotic prophase","volume":"438","author":"Hayashi","year":"2005","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib1100","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/MCB.23.4.1151-1162.2003","article-title":"Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase","volume":"23","author":"Baarends","year":"2003","journal-title":"Mol Cell Biol."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib1105","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1534-5807(03)00093-5","article-title":"H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis","volume":"4","author":"Fernandez-Capetillo","year":"2003","journal-title":"Dev Cell."},{"issue":"21","key":"10.1016\/j.phrs.2018.12.003_bib1110","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.1128\/MCB.21.21.7243-7255.2001","article-title":"Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice","volume":"21","author":"Zhao","year":"2001","journal-title":"Mol Cell Biol."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.003_bib1115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1095\/biolreprod.102.015115","article-title":"Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice","volume":"69","author":"Cho","year":"2003","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.003_bib1120","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/78153","article-title":"Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4","volume":"25","author":"Wu","year":"2000","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib1125","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/ng2031","article-title":"Modifiers of epigenetic reprogramming show paternal effects in the mouse","volume":"39","author":"Chong","year":"2007","journal-title":"Nat Genet."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.003_bib1130","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1530\/REP-17-0302","article-title":"EZH2 deletion promotes spermatogonial differentiation and apoptosis","volume":"154","author":"Jin","year":"2017","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.003_bib1135","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ydbio.2017.02.017","article-title":"EZH1 in germ cells safeguards the function of PRC2 during spermatogenesis","volume":"424","author":"Mu","year":"2017","journal-title":"Dev Biol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818314105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818314105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:56:09Z","timestamp":1760910969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818314105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":227,"alternative-id":["S1043661818314105"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2018.12.003","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research update and opportunity of non-hormonal male contraception: Histone demethylase KDM5B-based targeting","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2018.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}