{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:19:27Z","timestamp":1790770767037,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NARSAD Young Investigator","award":["22709"],"award-info":[{"award-number":["22709"]}]},{"name":"Brain & Behavior Research Foundation"},{"name":"National Institute Of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health","award":["R01DK107916"],"award-info":[{"award-number":["R01DK107916"]}]},{"name":"Yale Diabetes Research Center","award":["P30 DK045735"],"award-info":[{"award-number":["P30 DK045735"]}]},{"name":"Yale Center for Clinical Investigation Scholar Award"},{"DOI":"10.13039\/100001391","name":"Whitehall Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charles H. Hood Foundation, Inc. (Boston, MA)"},{"name":"Modern Diet and Physiology Research Center (The John B. Pierce Laboratory)"},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"name":"Coordenadoria de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"},{"name":"CNPq"},{"name":"CAPES"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.phrs.2018.12.024","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T12:00:50Z","timestamp":1546430450000},"page":"303-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Activation of Agrp neurons modulates memory-related cognitive processes in mice"],"prefix":"10.1016","volume":"141","author":[{"given":"Marcelo R.","family":"Zimmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-8580","authenticated-orcid":false,"given":"Ariana E.","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9781-2221","authenticated-orcid":false,"given":"Marcelo O.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.phrs.2018.12.024_bib0005","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1242\/jeb.103549","article-title":"Niche-specific cognitive strategies: object memory interferes with spatial memory in the predatory bat Myotis nattereri","volume":"217","author":"Hulgard","year":"2014","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.phrs.2018.12.024_bib0010","series-title":"Conditioned Reflexes","author":"Pavlov","year":"2003"},{"issue":"9","key":"10.1016\/j.phrs.2018.12.024_bib0015","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nrd3739","article-title":"Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons","volume":"11","author":"Dietrich","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.phrs.2018.12.024_bib0020","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1101\/gad.11.5.593","article-title":"Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice","volume":"11","author":"Shutter","year":"1997","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.024_bib0025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/1082","article-title":"Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons","volume":"1","author":"Hahn","year":"1998","journal-title":"Nat. Neurosci."},{"issue":"10","key":"10.1016\/j.phrs.2018.12.024_bib0030","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1210\/endo.139.10.6332","article-title":"A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo","volume":"139","author":"Rossi","year":"1998","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.phrs.2018.12.024_bib0035","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/nn1548","article-title":"Agouti-related peptide-expressing neurons are mandatory for feeding","volume":"8","author":"Gropp","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.024_bib0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuron.2016.08.032","article-title":"Hunger-driven motivational state competition","volume":"92","author":"Burnett","year":"2016","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.024_bib0045","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.cell.2015.02.024","article-title":"Hypothalamic agrp neurons drive stereotypic behaviors beyond feeding","volume":"160","author":"Dietrich","year":"2015","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.phrs.2018.12.024_bib0050","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/nn.4274","article-title":"Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state","volume":"19","author":"Padilla","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.024_bib0055","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cell.2014.09.010","article-title":"O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat","volume":"159","author":"Ruan","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2018.12.024_bib0060","series-title":"Barnes Maze, a Useful Task to Assess Spatial Reference Memory in the Mice","author":"Sunyer","year":"2007"},{"issue":"1","key":"10.1016\/j.phrs.2018.12.024_bib0065","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1037\/h0077579","article-title":"Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat","volume":"93","author":"Barnes","year":"1979","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.phrs.2018.12.024_bib0070","first-page":"1","article-title":"Spontaneous alternation behavior in humans","author":"Nguyen","year":"2017","journal-title":"Proceedings of the 23rd ACM Symposium on Virtual Reality Software and Technology"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.024_bib0075","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF02686603","article-title":"Spontaneous alternation behavior in animals: A review","volume":"5","author":"Richman","year":"1986","journal-title":"Curr. Psychol. Res. Rev."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.024_bib0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1037\/h0072784","article-title":"Purpose and cognition: the determiners of animal learning","volume":"32","author":"Tolman","year":"1925","journal-title":"Psychol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.024_bib0085","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0149-7634(01)00041-0","article-title":"The neurobiological basis of spontaneous alternation","volume":"26","author":"Lalonde","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.024_bib0090","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1037\/h0045446","article-title":"Spontaneous alternation behavior","volume":"55","author":"Dember","year":"1958","journal-title":"Psychol. Bull."},{"issue":"2","key":"10.1016\/j.phrs.2018.12.024_bib0095","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00428688","article-title":"Effects of delta9-THC, LSD-25 and scopolamine on continuous, spontaneous alternation in the Y-maze","volume":"32","author":"Drew","year":"1973","journal-title":"Psychopharmacologia"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.024_bib0100","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF00212843","article-title":"Attenuation of scopolamine-induced impairment of spontaneous alteration behaviour by antagonist but not inverse agonist and agonist beta-carbolines","volume":"94","author":"Sarter","year":"1988","journal-title":"Psychopharmacology (Berl.)"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.024_bib0105","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-2999(96)00622-X","article-title":"U-50488H, a selective kappa-opioid receptor agonist, improves carbon monoxide-induced delayed amnesia in mice","volume":"315","author":"Hiramatsu","year":"1996","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.phrs.2018.12.024_bib0110","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nn.2167","article-title":"Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance","volume":"11","author":"Tong","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"6587","key":"10.1016\/j.phrs.2018.12.024_bib0115","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/382168a0","article-title":"A receptor subtype involved in neuropeptide-Y-induced food intake","volume":"382","author":"Gerald","year":"1996","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.phrs.2018.12.024_bib0120","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nm0698-722","article-title":"Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor","volume":"4","author":"Pedrazzini","year":"1998","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.024_bib0125","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1210\/endo.141.3.7387","article-title":"Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice","volume":"141","author":"Kanatani","year":"2000","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.phrs.2018.12.024_bib0130","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/cne.10823","article-title":"Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry","volume":"464","author":"Wolak","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2018.12.024_bib0135","series-title":"Encyclopedia of Animal Behavior","first-page":"304","article-title":"Spatial memory","author":"Healy","year":"2010"},{"key":"10.1016\/j.phrs.2018.12.024_bib0140","series-title":"Learning and Memory: A Comprehensive Reference","first-page":"547","article-title":"4.27 - transcription regulation of memory: CREB, CaMKIV, Fos\/Jun, CBP, and SRF","author":"Cole","year":"2008"},{"key":"10.1016\/j.phrs.2018.12.024_bib0145","series-title":"Mechanisms of Memory (Second Edition)","first-page":"76","article-title":"Chapter 4 - rodent behavioral learning and memory models","author":"Sweatt","year":"2010"},{"key":"10.1016\/j.phrs.2018.12.024_bib0150","series-title":"Guide to Research Techniques in Neuroscience (Second Edition)","first-page":"39","article-title":"Chapter 2 - animal behavior","author":"Carter","year":"2015"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.024_bib0155","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0892-0362(00)00084-2","article-title":"Effects of prenatal cocaine on Morris and Barnes maze tests of spatial learning and memory in the offspring of C57BL\/6J mice","volume":"22","author":"Inman-Wood","year":"2000","journal-title":"Neurotoxicol. Teratol."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.024_bib0160","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1601-1848.2001.00005.x","article-title":"Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice","volume":"1","author":"Holmes","year":"2002","journal-title":"Genes Brain Behav."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.024_bib0165","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"D\u2019Hooge","year":"2001","journal-title":"Brain Res. Rev."},{"issue":"6","key":"10.1016\/j.phrs.2018.12.024_bib0170","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(95)90010-1","article-title":"Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency","volume":"81","author":"Bach","year":"1995","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2018.12.024_bib0175","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuron.2016.08.032","article-title":"Hunger-driven motivational state competition","volume":"92","author":"Burnett","year":"2016","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.phrs.2018.12.024_bib0180","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/ejn.12824","article-title":"Effects of defeat stress on behavioral flexibility in males and females: modulation by the mu-opioid receptor","volume":"41","author":"Laredo","year":"2015","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.024_bib0185","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1601-183X.2006.00221.x","article-title":"Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer\u2019s disease","volume":"6","author":"Reiserer","year":"2007","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.phrs.2018.12.024_bib0190","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1038\/srep06613","article-title":"IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours","volume":"4","author":"Yasumura","year":"2014","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.phrs.2018.12.024_bib0195","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00496859","article-title":"Interaction between cholinergic and catecholaminergic agents in a spontaneous alternation task","volume":"48","author":"Kokkinidis","year":"1976","journal-title":"Psychopharmacology (Berl.)"},{"issue":"2","key":"10.1016\/j.phrs.2018.12.024_bib0200","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00439098","article-title":"Perseveration and rotational behavior elicited by d-amphetamine in a Y-maze exploratory task: differential effects of intraperitoneal and unilateral intraventricular administration","volume":"52","author":"Kokkinidis","year":"1977","journal-title":"Psychopharmacology (Berl.)"},{"issue":"5","key":"10.1016\/j.phrs.2018.12.024_bib0205","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0091-3057(78)90388-X","article-title":"Abatement of stimulus perseveration following repeated d-amphetamine treatment: absence of behaviorally augmented tolerance","volume":"8","author":"Kokkinidis","year":"1978","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.phrs.2018.12.024_bib0210","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00426210","article-title":"Effects of scopolamine, d-amphetamine and other drugs affecting catecholamines on spontaneous alternation and locomotor activity in mice","volume":"45","author":"Anisman","year":"1975","journal-title":"Psychopharmacologia"},{"issue":"3","key":"10.1016\/j.phrs.2018.12.024_bib0215","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0149-7634(01)00066-5","article-title":"The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y","volume":"26","author":"Kask","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.024_bib0220","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0306-4522(00)00308-0","article-title":"Neuropeptide Y Y5 receptor protein in the cortical\/limbic system and brainstem of the rat: expression on \u03b3-aminobutyric acid and corticotropin-releasing hormone neurons","volume":"100","author":"Grove","year":"2000","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.phrs.2018.12.024_bib0225","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1749-6632.1990.tb48931.x","article-title":"Neuropeptide Y in cortex and striatum","volume":"611","author":"Aoki","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.phrs.2018.12.024_bib0230","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1172\/JCI46229","article-title":"Rapid, reversible activation of AgRP neurons drives feeding behavior in mice","volume":"121","author":"Krashes","year":"2011","journal-title":"J. Clin. Invest."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818319340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818319340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:45:49Z","timestamp":1565225149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818319340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":46,"alternative-id":["S1043661818319340"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2018.12.024","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of Agrp neurons modulates memory-related cognitive processes in mice","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2018.12.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}