{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:42:04Z","timestamp":1790336524594,"version":"4.1.0"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2012\/15205-4"],"award-info":[{"award-number":["2012\/15205-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2012\/02270-2"],"award-info":[{"award-number":["2012\/02270-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2016\/08907-3"],"award-info":[{"award-number":["2016\/08907-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2017\/05264-7"],"award-info":[{"award-number":["2017\/05264-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2017\/06222-6"],"award-info":[{"award-number":["2017\/06222-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"\u201cCoordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior \u2013 Brasil\u201d","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.phrs.2019.01.019","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T17:33:00Z","timestamp":1547141580000},"page":"366-377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":158,"special_numbering":"C","title":["The interplay among gut microbiota, hypertension and kidney diseases: The role of short-chain fatty acids"],"prefix":"10.1016","volume":"141","author":[{"given":"R.J.F.","family":"Felizardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. K.M.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Dardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.V.","family":"Rossoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.O.S.","family":"C\u00e2mara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2019.01.019_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and Bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0010","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature03001","article-title":"International Human Genome Sequencing Consortium, finishing the euchromatic sequence of the human genome","volume":"431","year":"2004","journal-title":"Nature."},{"key":"10.1016\/j.phrs.2019.01.019_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006074","article-title":"More than 9,000,000 unique genes in human gut bacterial community: estimating gene numbers inside a human body","volume":"4","author":"Yang","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2019.01.019_bib0020","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature06245","article-title":"An ecological and evolutionary perspective on human\u2013microbe mutualism and disease","volume":"449","author":"Dethlefsen","year":"2007","journal-title":"Nature."},{"key":"10.1016\/j.phrs.2019.01.019_bib0025","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature."},{"key":"10.1016\/j.phrs.2019.01.019_bib0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrmicro2974","article-title":"The gut microbiota \u2014 masters of host development and physiology","volume":"11","author":"Sommer","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0035","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1126\/science.1195568","article-title":"Has the microbiota played a critical role in the evolution of the adaptive immune system?","volume":"330","author":"Lee","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.phrs.2019.01.019_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.mehy.2009.08.047","article-title":"The human superorganism \u2013 of microbes and men","volume":"74","author":"Sleator","year":"2010","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.phrs.2019.01.019_bib0050","first-page":"26191","article-title":"Dysbiosis of the gut microbiota in disease","volume":"26","author":"Carding","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.phrs.2019.01.019_bib0055","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12263-011-0229-7","article-title":"Intestinal microbiota in human health and disease: the impact of probiotics","volume":"6","author":"Gerritsen","year":"2011","journal-title":"Genes Nutr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0060","article-title":"The placenta harbors a unique microbiome","volume":"6","author":"Aagaard","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.phrs.2019.01.019_bib0065","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00284-005-0020-3","article-title":"Isolation of commensal Bacteria from umbilical cord blood of healthy neonates born by cesarean section","volume":"51","author":"Jim\u00e9nez","year":"2005","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.resmic.2007.12.007","article-title":"Is meconium from healthy newborns actually sterile?","volume":"159","author":"Jim\u00e9nez","year":"2008","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0075","doi-asserted-by":"crossref","first-page":"11971","DOI":"10.1073\/pnas.1002601107","article-title":"Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns","volume":"107","author":"Dominguez-Bello","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phrs.2019.01.019_bib0080","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/0890334411424729","article-title":"Sharing of bacterial strains between breast milk and infant feces","volume":"28","author":"Mart\u00edn","year":"2012","journal-title":"J. Hum. Lact."},{"key":"10.1016\/j.phrs.2019.01.019_bib0085","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature."},{"key":"10.1016\/j.phrs.2019.01.019_bib0090","first-page":"46","article-title":"Profound perturbation induced by triclosan exposure in mouse gut microbiome: a less resilient microbial community with elevated antibiotic and metal resistomes, BMC Pharmacol","volume":"18","author":"Gao","year":"2017","journal-title":"Toxicol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0095","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1136\/gutjnl-2012-303184","article-title":"Gut microbiota disturbance during antibiotic therapy: a multi-omic approach","volume":"62","author":"P\u00e9rez-Cobas","year":"2013","journal-title":"Gut."},{"key":"10.1016\/j.phrs.2019.01.019_bib0100","first-page":"625","article-title":"The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level","volume":"67","author":"Barton","year":"2017","journal-title":"Gut."},{"key":"10.1016\/j.phrs.2019.01.019_bib0105","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1097\/01.mcg.0000128926.14285.25","article-title":"The first prebiotics in humans: human milk oligosaccharides","volume":"38","author":"Coppa","year":"2004","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0110","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jped.2017.05.013","article-title":"Breastfeeding increases microbial community resilience","volume":"94","author":"Carvalho-Ramos","year":"2018","journal-title":"J. Pediatr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0115","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1073\/pnas.1000081107","article-title":"Succession of microbial consortia in the developing infant gut microbiome","volume":"108","author":"Koenig","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phrs.2019.01.019_bib0120","doi-asserted-by":"crossref","DOI":"10.1126\/science.1237439","article-title":"The long-term stability of the human gut microbiota","volume":"341","author":"Faith","year":"2013","journal-title":"Science (80-.)"},{"key":"10.1016\/j.phrs.2019.01.019_bib0125","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1371\/journal.pbio.0060280","article-title":"The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing","volume":"6","author":"Dethlefsen","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0130","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"The Human Microbiome Project Consortium, Structure, function and diversity of the healthy human microbiome","volume":"486","year":"2012","journal-title":"Nature."},{"key":"10.1016\/j.phrs.2019.01.019_bib0135","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nbt.2942","article-title":"An integrated catalog of reference genes in the human gut microbiome","volume":"32","author":"Li","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0140","doi-asserted-by":"crossref","first-page":"14691","DOI":"10.1073\/pnas.1005963107","article-title":"Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa","volume":"107","author":"De Filippo","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phrs.2019.01.019_bib0145","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.chom.2015.05.012","article-title":"Dynamics and stabilization of the human gut microbiome during the first year of life","volume":"17","author":"B\u00e4ckhed","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phrs.2019.01.019_bib0150","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1073\/pnas.1310750111","article-title":"House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection","volume":"111","author":"Fujimura","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phrs.2019.01.019_bib0155","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2012.10.052","article-title":"Xenobiotics shape the physiology and gene expression of the active human gut microbiome","volume":"152","author":"Maurice","year":"2013","journal-title":"Cell."},{"key":"10.1016\/j.phrs.2019.01.019_bib0160","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2014.09.053","article-title":"Human genetics shape the gut microbiome","volume":"159","author":"Goodrich","year":"2014","journal-title":"Cell."},{"key":"10.1016\/j.phrs.2019.01.019_bib0165","doi-asserted-by":"crossref","first-page":"11512","DOI":"10.1073\/pnas.0801925105","article-title":"Colloquium paper: resistance, resilience, and redundancy in microbial communities","volume":"105","author":"Allison","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.01.019_bib0170","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fmicb.2013.00112","article-title":"Links between metabolic plasticity and functional redundancy in freshwater bacterioplankton communities","volume":"4","author":"Comte","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0175","series-title":"Role of the Indigenous Microbiota in Maintaining Human Health","first-page":"375","article-title":"Microbial inhabitants of humans: Their ecology and role in health and disease","author":"Wilson","year":"2005"},{"key":"10.1016\/j.phrs.2019.01.019_bib0180","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S1286-4579(01)01460-5","article-title":"IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms","volume":"3","author":"Macpherson","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.phrs.2019.01.019_bib0185","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1038\/ncomms4704","article-title":"Generation of colonic IgA-secreting cells in the caecal patch","volume":"5","author":"Masahata","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2019.01.019_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: metabolism of nutrients and other food \u2009components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0195","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4161\/gmic.19897","article-title":"Microbial degradation of complex carbohydrates in the gut","volume":"3","author":"Flint","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2019.01.019_bib0200","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0140-6736(03)12489-0","article-title":"Gut flora in health and disease","volume":"361","author":"Guarner","year":"2003","journal-title":"Lancet."},{"key":"10.1016\/j.phrs.2019.01.019_bib0205","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1128\/aem.62.5.1589-1592.1996","article-title":"Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora","volume":"62","author":"Miller","year":"1996","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0210","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2019.01.019_bib0215","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"den Besten","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phrs.2019.01.019_bib0220","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1017\/S0007114508888733","article-title":"Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability","volume":"100","author":"Suzuki","year":"2008","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0225","doi-asserted-by":"crossref","first-page":"2485S","DOI":"10.1093\/jn\/133.7.2485S","article-title":"Inhibition of histone deacetylase activity by butyrate","volume":"133","author":"Davie","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0230","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1093\/jn\/131.6.1770","article-title":"Whole wheat and Triticale flours with differing viscosities stimulate cecal fermentations and lower plasma and hepatic lipids in rats","volume":"131","author":"Adam","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0235","first-page":"57","article-title":"Comparison of fermentation reactions in different regions of the human colon","volume":"72","author":"Macfarlane","year":"1992","journal-title":"J. Appl. Bacteriol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0240","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1079\/BJN20041150","article-title":"Contribution of acetate to butyrate formation by human faecal bacteria","volume":"91","author":"Duncan","year":"2004","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0245","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1038\/ncomms4611","article-title":"The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism","volume":"5","author":"Frost","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2019.01.019_bib0250","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature18309","article-title":"Acetate mediates a microbiome-brain-\u03b2-cell axis to promote metabolic syndrome","volume":"534","author":"Perry","year":"2016","journal-title":"Nature."},{"key":"10.1016\/j.phrs.2019.01.019_bib0255","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.clnu.2009.05.011","article-title":"S.W. Olde Damink, W.A. Buurman, C.H. Dejong, Short chain fatty acids exchange across the gut and liver in humans measured at surgery","volume":"28","author":"Bloemen","year":"2009","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0260","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The orphan g protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2019.01.019_bib0265","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/112_2013_13","article-title":"Free fatty acid receptors and their role in regulation of energy metabolism","author":"Hara","year":"2013","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0270","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1124\/mol.115.102301","article-title":"The pharmacology and function of receptors for short-chain fatty acids","volume":"89","author":"Bolognini","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0275","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1073\/pnas.1016088108","article-title":"Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)","volume":"108","author":"Kimura","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.01.019_bib0280","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1210\/en.2008-0059","article-title":"Activation of g protein-coupled receptor 43 in adipocytes leads to inhibition of Lipolysis and suppression of plasma free fatty acids","volume":"149","author":"Ge","year":"2008","journal-title":"Endocrinology."},{"key":"10.1016\/j.phrs.2019.01.019_bib0285","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bbrc.2012.07.082","article-title":"Effects of high fat diet on GPR109A and GPR81 gene expression","volume":"425","author":"Wanders","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2019.01.019_bib0290","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2220\/biomedres.30.149","article-title":"Expression of short-chain fatty acid receptor GPR41 in the human colon","volume":"30","author":"Tazoe","year":"2009","journal-title":"Biomed. Res."},{"key":"10.1016\/j.phrs.2019.01.019_bib0295","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1158\/0008-5472.CAN-08-4466","article-title":"GPR109A is a G-protein-Coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in Colon","volume":"69","author":"Thangaraju","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2019.01.019_bib0300","doi-asserted-by":"crossref","first-page":"25481","DOI":"10.1074\/jbc.M301403200","article-title":"Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation","volume":"278","author":"Le Poul","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2019.01.019_bib0305","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.cdd.4402238","article-title":"Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A)","volume":"15","author":"Kostylina","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2019.01.019_bib0310","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1152\/physiolgenomics.00089.2016","article-title":"Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41","volume":"48","author":"Natarajan","year":"2016","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.phrs.2019.01.019_bib0315","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.atherosclerosis.2014.10.090","article-title":"Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity","volume":"237","author":"Hughes-Large","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.phrs.2019.01.019_bib0320","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1073\/pnas.0812859106","article-title":"Functional expression of the olfactory signaling system in the kidney","volume":"106","author":"Pluznick","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.01.019_bib0325","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1073\/pnas.1215927110","article-title":"Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation","volume":"110","author":"Pluznick","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phrs.2019.01.019_bib0330","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1073\/pnas.2637002100","article-title":"Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41","volume":"101","author":"Xiong","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.01.019_bib0335","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1600-0773.1994.tb00344.x","article-title":"Short chain fatty acids relax isolated resistance arteries from the human ileum by a mechanism dependent on anion-exchange","volume":"75","author":"Mortensen","year":"1994","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0340","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1161\/HYPERTENSIONAHA.118.11175","article-title":"Attenuation of microbiotal dysbiosis and hypertension in a CRISPR\/Cas9 gene ablation rat model of GPER1","volume":"72","author":"Waghulde","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2019.01.019_bib0345","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0168-1605(98)00044-0","article-title":"Overview of gut flora and probiotics","volume":"41","author":"Holzapfel","year":"1998","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0350","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm.4176","article-title":"Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation","volume":"22","author":"Fujimura","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2019.01.019_bib0355","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/MCG.0000000000000356","article-title":"Dysbiosis: a review highlighting obesity and inflammatory bowel disease","volume":"49","author":"Kim","year":"2015","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0360","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nature07336","article-title":"Innate immunity and intestinal microbiota in the development of Type 1 diabetes","volume":"455","author":"Wen","year":"2008","journal-title":"Nature."},{"key":"10.1016\/j.phrs.2019.01.019_bib0365","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fncel.2017.00120","article-title":"The gut microbiota and autism Spectrum disorders","volume":"11","author":"Li","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2019.01.019_bib0370","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/gutjnl-2013-304833","article-title":"A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis","volume":"63","author":"Machiels","year":"2014","journal-title":"Gut."},{"key":"10.1016\/j.phrs.2019.01.019_bib0375","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrmicro.2017.149","article-title":"Microbial modulation of cardiovascular disease","volume":"16","author":"Brown","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0380","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1016\/j.crvasa.2013.07.006","article-title":"Hypertension and chronic kidney diseases","volume":"55","author":"Monhart","year":"2013","journal-title":"Cor Vasa"},{"key":"10.1016\/j.phrs.2019.01.019_bib0385","first-page":"37","article-title":"Hypertension and chronic kidney disease: controversies in pathogenesis and treatment","volume":"65","author":"Pirkle","year":"2013","journal-title":"Minerva Urol. Nefrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0390","article-title":"Essential hypertension","volume":"101","author":"Carretero","year":"2000","journal-title":"Circulation."},{"key":"10.1016\/j.phrs.2019.01.019_bib0395","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1681\/ASN.2005010063","article-title":"Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?","volume":"16","author":"Johnson","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0400","first-page":"402","article-title":"Epidemiology and causes of chronic kidney disease","volume":"39","author":"Evans","year":"2011","journal-title":"Bull. Sch. Med. Md"},{"key":"10.1016\/j.phrs.2019.01.019_bib0405","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/132405","article-title":"Hypertension in chronic kidney disease: navigating the evidence","volume":"2011","author":"Tedla","year":"2011","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.phrs.2019.01.019_bib0410","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1681\/ASN.2005121319","article-title":"Importance of blood pressure control in chronic kidney disease","volume":"17","author":"Ravera","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0415","series-title":"USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States., 2018","author":"Saran","year":"2017"},{"key":"10.1016\/j.phrs.2019.01.019_bib0420","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1053\/j.ajkd.2009.09.014","article-title":"Hypertension awareness, treatment, and control in adults with CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study","volume":"55","author":"Muntner","year":"2010","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.phrs.2019.01.019_bib0425","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0140-6736(16)31919-5","article-title":"Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19\u00b71 million participants","volume":"389","author":"Zhou","year":"2017","journal-title":"Lancet."},{"key":"10.1016\/j.phrs.2019.01.019_bib0430","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/CIR.0000000000000366","article-title":"Executive summary: heart disease and stroke statistics\u20142016 update","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2019.01.019_bib0435","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jash.2012.11.007","article-title":"The mosaic theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension","volume":"7","author":"Harrison","year":"2013","journal-title":"J. Am. Soc. Hypertens."},{"key":"10.1016\/j.phrs.2019.01.019_bib0440","series-title":"Gut Microbiota Dysbiosis Contributes to the Development of Hypertension","author":"Li","year":"2017"},{"key":"10.1016\/j.phrs.2019.01.019_bib0445","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1152\/physiolgenomics.00136.2014","article-title":"Evidence for a link between gut microbiota and hypertension in the Dahl rat","volume":"47","author":"Mell","year":"2015","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.phrs.2019.01.019_bib0450","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/HYPERTENSIONAHA.115.05315","article-title":"Gut microbiota dysbiosis is linked to hypertension","volume":"65","author":"Yang","year":"2015","journal-title":"Hypertension."},{"key":"10.1016\/j.phrs.2019.01.019_bib0455","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.107.3.437","article-title":"Irreversible hemorrhagic shock in germfree rats","volume":"107","author":"Zweifach","year":"1958","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2019.01.019_bib0460","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1084\/jem.134.4.846","article-title":"Tone and reactivity of vascular smooth muscle in germfree rat mesentery","volume":"134","author":"Baez","year":"1971","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2019.01.019_bib0465","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003698","article-title":"Gut microbiota promote angiotensin II\u2013Induced arterial hypertension and vascular dysfunction","volume":"5","author":"Karbach","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.phrs.2019.01.019_bib0470","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/CS20180087","article-title":"Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure","volume":"132","author":"Kim","year":"2018","journal-title":"Clin. Sci."},{"key":"10.1016\/j.phrs.2019.01.019_bib0475","series-title":"A High Salt Diet Modulates the Gut Microbiota and Short Chain Fatty Acids Production in a Salt-Sensitive Hypertension Rat Model","author":"Bier","year":"2018"},{"key":"10.1016\/j.phrs.2019.01.019_bib0480","doi-asserted-by":"crossref","first-page":"g4490","DOI":"10.1136\/bmj.g4490","article-title":"Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies","volume":"349","author":"Wang","year":"2014","journal-title":"BMJ."},{"key":"10.1016\/j.phrs.2019.01.019_bib0485","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/aje\/kwh085","article-title":"Relation of vegetable, fruit, and meat intake to 7-year blood pressure change in middle-aged men: the Chicago Western Electric Study","volume":"159","author":"Miura","year":"2004","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0490","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/CIRCRESAHA.116.309006","article-title":"Hypertension-linked pathophysiological alterations in the gut","volume":"120","author":"Santisteban","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2019.01.019_bib0495","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.ajpath.2013.01.013","article-title":"Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis","volume":"182","author":"Bergmann","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0500","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1152\/physiolgenomics.00073.2018","article-title":"Disparate effects of antibiotics on hypertension","volume":"50","author":"Galla","year":"2018","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.phrs.2019.01.019_bib0505","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.celrep.2018.09.058","article-title":"Salt-responsive metabolite, \u03b2-Hydroxybutyrate, attenuates hypertension","volume":"25","author":"Chakraborty","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2019.01.019_bib0510","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3389\/fimmu.2015.00639","article-title":"The Treg\/Th17 Axis: a dynamic balance regulated by the gut microbiome","volume":"6","author":"Omenetti","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0515","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature24628","article-title":"Salt-responsive gut commensal modulates TH17 axis and disease","volume":"551","author":"Wilck","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.phrs.2019.01.019_bib0520","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-0897-4_1","article-title":"Microbial Endocrinology and the Microbiota-Gut-Brain Axis","author":"Lyte","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0525","first-page":"4225","article-title":"Single cell transcriptome analysis of mouse carotid body glomus cells","volume":"594","author":"Zhou","year":"2016","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.phrs.2019.01.019_bib0530","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1681\/ASN.2014030288","article-title":"Gut Bacteria products prevent AKI induced by ischemia-reperfusion","volume":"26","author":"Andrade-Oliveira","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0535","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","article-title":"Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members, Evaluation and Management of Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2012 Clinical Practice Guideline","volume":"158","author":"Stevens","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.phrs.2019.01.019_bib0540","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrneph.2017.30","article-title":"Metabolomics for clinical use and research in chronic kidney disease","volume":"13","author":"Hocher","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0545","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1681\/ASN.V561339","article-title":"Intestinal excretion of oxalate in chronic renal failure","volume":"5","author":"Hatch","year":"1994","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0550","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1042\/cs0860511","article-title":"Enhanced enteric excretion of urate in rats with chronic renal failure","volume":"86","author":"Hatch","year":"1994","journal-title":"Clin. Sci."},{"key":"10.1016\/j.phrs.2019.01.019_bib0555","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000360010","article-title":"Expansion of urease- and uricase-containing, indole- and p-Cresol-Forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD","volume":"39","author":"Wong","year":"2014","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0560","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1046\/j.1523-1755.2003.00906.x","article-title":"Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-\u03baB and free radical in proximal tubular cells","volume":"63","author":"Motojima","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2019.01.019_bib0565","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/ki.2011.445","article-title":"Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation","volume":"81","author":"Sun","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2019.01.019_bib0570","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000168716","article-title":"Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate","volume":"14","author":"Niwa","year":"1994","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0575","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1159\/000064291","article-title":"Effects of oral adsorbent AST-120 (Kremezin) on renal function and glomerular injury in early-stage renal failure of subtotal nephrectomized rats","volume":"91","author":"Kobayashi","year":"2002","journal-title":"Nephron."},{"key":"10.1016\/j.phrs.2019.01.019_bib0580","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108448","article-title":"Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand","volume":"9","author":"Ichii","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2019.01.019_bib0585","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0590","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1038\/cti.2016.36","article-title":"The microbiota and chronic kidney diseases: a double-edged sword","volume":"5","author":"Felizardo","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0595","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ki.2012.345","article-title":"Chronic kidney disease alters intestinal microbial flora","volume":"83","author":"Vaziri","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2019.01.019_bib0600","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1681\/ASN.2015111285","article-title":"Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD\u2013Related Systemic Inflammation","volume":"28","author":"Andersen","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0605","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1681\/ASN.2015030279","article-title":"The influence of CKD on colonic microbial metabolism","volume":"27","author":"Poesen","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0610","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000345969","article-title":"Role of urea in intestinal barrier dysfunction and disruption of epithelial tight junction in chronic kidney disease","volume":"37","author":"Vaziri","year":"2013","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0615","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2215\/CJN.03490708","article-title":"Circulating bacterial-derived DNA fragments and markers of inflammation in chronic hemodialysis patients","volume":"4","author":"Bossola","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0620","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1440-1797.2012.01647.x","article-title":"Gut bacterial translocation is associated with microinflammation in end-stage renal disease patients","volume":"17","author":"Wang","year":"2012","journal-title":"Nephrology."},{"key":"10.1016\/j.phrs.2019.01.019_bib0625","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1007\/s10620-014-3202-7","article-title":"Gut bacterial translocation may aggravate microinflammation in hemodialysis patients","volume":"59","author":"Shi","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.phrs.2019.01.019_bib0630","doi-asserted-by":"crossref","first-page":"F1457","DOI":"10.1152\/ajprenal.90769.2008","article-title":"Early exposure to germs modifies kidney damage and inflammation after experimental ischemia-reperfusion injury","volume":"297","author":"Jang","year":"2009","journal-title":"Am. J. Physiol. Physiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0635","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5527\/wjn.v5.i3.258","article-title":"Stop chronic kidney disease progression: time is approaching","volume":"5","author":"El Din","year":"2016","journal-title":"World J. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0640","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cmet.2016.10.021","article-title":"Diet-microbiome interactions in health are controlled by intestinal nitrogen source constraints","volume":"25","author":"Holmes","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2019.01.019_bib0645","first-page":"26164","article-title":"Contribution of diet to the composition of the human gut microbiota","volume":"26","author":"Graf","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.phrs.2019.01.019_bib0650","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/s41564-018-0267-7","article-title":"Microbial nitrogen limitation in the mammalian large intestine","volume":"3","author":"Reese","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0655","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell."},{"key":"10.1016\/j.phrs.2019.01.019_bib0660","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/ki.2011.355","article-title":"High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease","volume":"81","author":"Raj Krishnamurthy","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2019.01.019_bib0665","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.2215\/CJN.00250117","article-title":"eGFR and the risk of community-acquired infections","volume":"12","author":"Xu","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0670","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"Lozupone","year":"2012","journal-title":"Nature."},{"key":"10.1016\/j.phrs.2019.01.019_bib0675","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.clnu.2014.08.009","article-title":"Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM 15313 and effects on the gut microbiota in healthy rats","volume":"34","author":"Ahr\u00e9n","year":"2015","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.phrs.2019.01.019_bib0680","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.jhh.1001745","article-title":"Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension","volume":"18","author":"Tuomilehto","year":"2004","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.phrs.2019.01.019_bib0685","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1002\/mnfr.201500290","article-title":"Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats","volume":"59","author":"G\u00f3mez-Guzm\u00e1n","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phrs.2019.01.019_bib0690","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/HYPERTENSIONAHA.114.03469","article-title":"Effect of probiotics on blood pressure","volume":"64","author":"Khalesi","year":"2014","journal-title":"Hypertension."},{"key":"10.1016\/j.phrs.2019.01.019_bib0695","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/CIRCULATIONAHA.116.024545","article-title":"High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice","volume":"135","author":"Marques","year":"2017","journal-title":"Circulation."},{"key":"10.1016\/j.phrs.2019.01.019_bib0700","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1038\/cti.2016.17","article-title":"Regulation of immune cell function by short-chain fatty acids","volume":"5","author":"Corr\u00eaa-Oliveira","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0705","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/nu3100858","article-title":"Regulation of inflammation by short chain fatty acids","volume":"3","author":"Vinolo","year":"2011","journal-title":"Nutrients."},{"key":"10.1016\/j.phrs.2019.01.019_bib0710","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ki.2015.255","article-title":"Probiotics and chronic kidney disease","volume":"88","author":"Koppe","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2019.01.019_bib0715","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000452453","article-title":"Liquid Chromatography\/Mass spectrometry reveals the effect of Lactobacillus treatment on the faecal metabolite profile of rats with chronic renal failure","volume":"135","author":"Wu","year":"2017","journal-title":"Nephron."},{"key":"10.1016\/j.phrs.2019.01.019_bib0720","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2215\/CJN.05240515","article-title":"Synbiotics easing renal failure by improving gut microbiology (SYNERGY): a randomized trial","volume":"11","author":"Rossi","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0725","doi-asserted-by":"crossref","first-page":"34712","DOI":"10.1038\/srep34712","article-title":"Hyperoxaluria leads to dysbiosis and drives selective enrichment of oxalate metabolizing bacterial species in recurrent kidney stone endures","volume":"6","author":"Suryavanshi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2019.01.019_bib0730","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/ki.2013.104","article-title":"The role of Oxalobacter formigenes colonization in calcium oxalate stone disease","volume":"83","author":"Siener","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2019.01.019_bib0735","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00240-013-0601-8","article-title":"A human strain of Oxalobacter (HC-1) promotes enteric oxalate secretion in the small intestine of mice and reduces urinary oxalate excretion","volume":"41","author":"Hatch","year":"2013","journal-title":"Urolithiasis."},{"key":"10.1016\/j.phrs.2019.01.019_bib0740","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/ndt\/gfp414","article-title":"p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin","volume":"25","author":"Meijers","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.phrs.2019.01.019_bib0745","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.2215\/CJN.00490114","article-title":"Effect of increasing dietary Fiber on plasma levels of colon-derived solutes in hemodialysis patients","volume":"9","author":"Sirich","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0750","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114881","article-title":"High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease","volume":"9","author":"Vaziri","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2019.01.019_bib0755","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cell.2018.08.047","article-title":"Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT","volume":"174","author":"Suez","year":"2018","journal-title":"Cell."},{"key":"10.1016\/j.phrs.2019.01.019_bib0760","first-page":"1046","article-title":"Clostridium difficile infection in patients with chronic kidney disease, mayo clin","volume":"87","author":"Keddis","year":"2012","journal-title":"Proc."},{"key":"10.1016\/j.phrs.2019.01.019_bib0765","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000351757","article-title":"Renal impairment and clinical outcomes of Clostridium difficile infection in two randomized trials","volume":"38","author":"Mullane","year":"2013","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.phrs.2019.01.019_bib0770","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofv078","article-title":"Loss of vancomycin-resistant Enterococcus Fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant","volume":"2","author":"Stripling","year":"2015","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.phrs.2019.01.019_bib0775","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12934-015-0394-2","article-title":"Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide","volume":"14","author":"Yang","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.phrs.2019.01.019_bib0780","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/ni.3713","article-title":"Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes","volume":"18","author":"Mari\u00f1o","year":"2017","journal-title":"Nat. Immunol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818316840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818316840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:58:53Z","timestamp":1760911133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818316840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":156,"alternative-id":["S1043661818316840"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2019.01.019","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interplay among gut microbiota, hypertension and kidney diseases: The role of short-chain fatty acids","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2019.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}