{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:32:04Z","timestamp":1792787524697,"version":"4.5.0"},"reference-count":321,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Faculty of Pharmacy, Jagiellonian University Medical College","award":["K\/ZDS\/007869"],"award-info":[{"award-number":["K\/ZDS\/007869"]}],"id":[{"id":"https:\/\/ror.org\/03bqmcz70","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.phrs.2019.02.001","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T18:47:09Z","timestamp":1549824429000},"page":"30-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Recent advances in the neurobiology of posttraumatic stress disorder: A review of possible mechanisms underlying an effective pharmacotherapy"],"prefix":"10.1016","volume":"142","author":[{"given":"Natalia","family":"Malikowska-Racia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Salat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2019.02.001_bib0005","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1471-4159.2005.03342.x","article-title":"Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system","volume":"95","author":"Kim","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2019.02.001_bib0015","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1073\/pnas.1017820108","article-title":"Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism","volume":"108","author":"Ros-Bernal","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib0020","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.pnpbp.2010.08.026","article-title":"In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression","volume":"35","author":"Kubera","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0025","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1176\/ajp.156.6.837","article-title":"Causal relationship between stressful life events and the onset of major depression","volume":"156","author":"Kendler","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0030","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1073\/pnas.0705615105","article-title":"Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy","volume":"105","author":"Mitra","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cpr.2017.09.001","article-title":"A review of current evidence regarding the ICD-11 proposals for diagnosing PTSD and complex PTSD","volume":"58","author":"Brewin","year":"2017","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.phrs.2019.02.001_bib0040","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.phrs.2019.02.001_bib0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/jts.21814","article-title":"The co-occurrence of major depressive disorder among individuals with posttraumatic stress disorder: a meta-analysis","volume":"26","author":"Rytwinski","year":"2013","journal-title":"J. Trauma. Stress"},{"key":"10.1016\/j.phrs.2019.02.001_bib0050","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jagp.2017.03.012","article-title":"Post-traumatic stress disorder and risk of parkinson disease: a nationwide longitudinal study","volume":"25","author":"Chan","year":"2017","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0055","series-title":"VA\/DOD Clinical Practice Guideline for the Management of Posttraumatic Stress Disorder and Acute Stress Disorder","author":"The Management of Posttraumatic Stress Disorder Work Group","year":"2017"},{"key":"10.1016\/j.phrs.2019.02.001_bib0060","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1001\/archpsyc.60.10.1024","article-title":"A randomized controlled trial of cognitive therapy, a self-help booklet, and repeated assessments as early interventions for posttraumatic stress disorde","volume":"60","author":"Ehlers","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0065","doi-asserted-by":"crossref","DOI":"10.7812\/TPP\/17-207","article-title":"Cognitive behavioral therapy with heart rate variability biofeedback for adults with persistent noncombat-related posttraumatic stress disorder","volume":"22","author":"Criswell","year":"2018","journal-title":"Perm. J."},{"key":"10.1016\/j.phrs.2019.02.001_bib0070","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nn.3582","article-title":"Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety","volume":"17","author":"Likhtik","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0075","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0079-6123(07)67025-3","article-title":"Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder","volume":"167","author":"de Kloet","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0080","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1176\/ajp.156.4.585","article-title":"Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder","volume":"156","author":"Baker","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0085","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.psyneuen.2007.12.012","article-title":"Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorder","volume":"33","author":"Geracioti","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0090","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.psyneuen.2014.12.005","article-title":"Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating","volume":"53","author":"Flandreau","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0095","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/npp.2011.256","article-title":"Consolidation of remote fear memories involves corticotropin-releasing hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus","volume":"37","author":"Thoeringer","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0100","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/en.2017-00336","article-title":"Corticotropin-releasing hormone suppresses synapse formation in the hippocampus of male rats via inhibition of CXCL5 secretion by glia","volume":"159","author":"Zhang","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.neuropharm.2016.05.008","article-title":"Corticotropin-releasing factor in ventromedial prefrontal cortex mediates avoidance of a traumatic stress-paired context","volume":"113","author":"Schreiber","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0110","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/10253890500504557","article-title":"Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety","volume":"8","author":"Shekhar","year":"2005","journal-title":"Stress"},{"key":"10.1016\/j.phrs.2019.02.001_bib0115","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1017\/S1461145709990496","article-title":"CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD","volume":"13","author":"Adamec","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0120","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/npp.2014.316","article-title":"The CRH1 antagonist GSK561679 increases human fear but not anxiety as assessed by startle","volume":"40","author":"Grillon","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0125","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.biopsych.2017.06.024","article-title":"Corticotropin-releasing factor receptor 1 antagonism is ineffective for women with posttraumatic stress disorder","volume":"82","author":"Dunlop","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0130","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/da.20695","article-title":"Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder","volume":"27","author":"Coric","year":"2010","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.phrs.2019.02.001_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1600001","article-title":"The role of corticotropin-releasing factor in depression and anxiety disorders","volume":"160","author":"Arborelius","year":"1999","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbr.2016.03.013","article-title":"The activation and blockage of CRF type 2 receptors of the medial amygdala alter elevated T-maze inhibitory avoidance, an anxiety-related response","volume":"305","author":"Alves","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0145","doi-asserted-by":"crossref","first-page":"16206","DOI":"10.3402\/ejpt.v3i0.16206","article-title":"Neuroendocrine and immune responses to a cognitive stress challenge in veterans with and without PTSD","volume":"3","author":"de Kloet","year":"2012","journal-title":"Eur. J. Psychotraumatol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0150","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.jpsychires.2008.01.015","article-title":"Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder","volume":"42","author":"Str\u00f6hle","year":"2008","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1196\/annals.1364.012","article-title":"Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications","volume":"1071","author":"Yehuda","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0160","doi-asserted-by":"crossref","first-page":"e1002379","DOI":"10.1371\/journal.pcbi.1002379","article-title":"Modeling cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and post-traumatic stress disorder (PTSD) in humans","volume":"8","author":"Sriram","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0165","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.psyneuen.2006.09.003","article-title":"HPA- and HPT-axis alterations in chronic posttraumatic stress disorder","volume":"31","author":"Olff","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0170","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0006-3223(01)01253-7","article-title":"Salivary cortisol, posttraumatic stress symptoms, and general health in the acute phase and during 9-month follow-up","volume":"50","author":"Aardal-Eriksson","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pscychresns.2016.12.004","article-title":"Evidence for the changes of pituitary volumes in patients with post-traumatic stress disorder","volume":"260","author":"Atmaca","year":"2017","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.phrs.2019.02.001_bib0180","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF03040918","article-title":"Increase of serum triiodothyronine concentration in soldiers with combat-related chronic post-traumatic stress disorder with or without alcohol dependence","volume":"116","author":"Karlovi\u0107","year":"2004","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.phrs.2019.02.001_bib0185","doi-asserted-by":"crossref","first-page":"e26582","DOI":"10.1371\/journal.pone.0026582","article-title":"Adult-onset hypothyroidism enhances fear memory and upregulates mineralocorticoid and glucocorticoid receptors in the amygdala","volume":"6","author":"Montero-Pedrazuela","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2019.02.001_bib0190","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10072-011-0597-1","article-title":"Expression of locus coeruleus mineralocorticoid receptor and glucocorticoid receptor in rats under single-prolonged stress","volume":"32","author":"Li","year":"2011","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0195","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0306-4530(97)00044-9","article-title":"Stress-restress: effects on ACTH and fast feedback","volume":"22","author":"Liberzon","year":"1997","journal-title":"Pergamon Psychoneuroendocrinol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0200","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1210\/edrv-7-3-284","article-title":"The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis","volume":"7","author":"Sapolsky","year":"1986","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phrs.2019.02.001_bib0205","first-page":"1573","article-title":"Regulation of corticotropin-releasing hormone secretion by ACTH at different times after adrenalectomy","volume":"29","author":"Castro","year":"1996","journal-title":"Rev. Bras. Pesqui. Med."},{"key":"10.1016\/j.phrs.2019.02.001_bib0210","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1172\/JCI10002","article-title":"Regulation of adrenocorticotropic hormone secretion: lessons from mice deficient in corticotropin-releasing hormone","volume":"105","author":"Seasholtz","year":"2000","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.phrs.2019.02.001_bib0215","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1176\/appi.ajp.159.11.1938","article-title":"Mineralocorticoid receptor function in patients with posttraumatic stress disorder","volume":"159","author":"Kellner","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0220","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1267\/ahc.08013","article-title":"Expressions of hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the single-prolonged stress-rats","volume":"41","author":"Zhe","year":"2008","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.phrs.2019.02.001_bib0225","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.psyneuen.2017.05.023","article-title":"Dexamethasone facilitates fear extinction and safety discrimination in PTSD: a placebo-controlled, double-blind study","volume":"83","author":"Michopoulos","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0230","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.psyneuen.2014.08.004","article-title":"Cortisol augmentation of a psychological treatment for warfighters with posttraumatic stress disorder: randomized trial showing improved treatment retention and outcome","volume":"51","author":"Yehuda","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0235","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/10253890.2015.1094689","article-title":"Post-traumatic stress avoidance is attenuated by corticosterone and associated with brain levels of steroid receptor co-activator-1 in rats","volume":"19","author":"Whitaker","year":"2016","journal-title":"Stress"},{"key":"10.1016\/j.phrs.2019.02.001_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/393251","article-title":"A pilot study of mifepristone in combat-related PTSD","volume":"2012","author":"Golier","year":"2012","journal-title":"Depress. Res. Treat."},{"key":"10.1016\/j.phrs.2019.02.001_bib0245","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.psyneuen.2015.11.001","article-title":"A randomized, double-blind, placebo-controlled, crossover trial of mifepristone in Gulf War veterans with chronic multisymptom illness","volume":"64","author":"Golier","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0250","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1523\/JNEUROSCI.09-09-03072.1989","article-title":"Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo\u2013pituitary\u2013adrenocortical axis","volume":"9","author":"Herman","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0255","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0031-9384(96)00410-6","article-title":"Cardiorespiratory components of defense reaction elicited from paraventricular nucleus","volume":"61","author":"Duan","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.phrs.2019.02.001_bib0260","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.expneurol.2016.05.014","article-title":"Noradrenergic dysregulation in the pathophysiology of PTSD","volume":"284","author":"Hendrickson","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0265","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1046\/j.1365-2826.2002.00867.x","article-title":"Neurosecretory and non-neurosecretory parvocellular neurones of the hypothalamic paraventricular nucleus express distinct electrophysiological properties","volume":"14","author":"Luther","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0270","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nn.4491","article-title":"Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress","volume":"20","author":"Ramot","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0275","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1523\/JNEUROSCI.1492-17.2017","article-title":"Local corticotropin-releasing factor signaling in the hypothalamic paraventricular nucleus","volume":"38","author":"Jiang","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0280","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbr.2016.06.016","article-title":"Amelioration of oxidative stress-induced phenotype loss of parvalbumin interneurons might contribute to the beneficial effects of environmental enrichment in a rat model of post-traumatic stress disorder","volume":"312","author":"Sun","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0285","first-page":"265","article-title":"GAD65 haplodeficiency conveys resilience in animal models of stress-induced psychopathology","volume":"8","author":"M\u00fcller","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0290","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/10253890500070005","article-title":"Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus","volume":"7","author":"Jo\u00ebls","year":"2004","journal-title":"Stress"},{"key":"10.1016\/j.phrs.2019.02.001_bib0295","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1111\/bph.13924","article-title":"Neuroadaptations of presynaptic and postsynaptic GABA B receptor function in the paraventricular nucleus in response to chronic unpredictable stress","volume":"174","author":"Gao","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0300","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/JCP.0000000000000089","article-title":"Baclofen add-on to citalopram in treatment of posttraumatic stress disorder","volume":"34","author":"Manteghi","year":"2014","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0305","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1345\/aph.1C465","article-title":"Baclofen treatment for chronic posttraumatic stress disorder","volume":"37","author":"Drake","year":"2003","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.phrs.2019.02.001_bib0310","doi-asserted-by":"crossref","first-page":"9908","DOI":"10.1038\/s41598-018-28321-0","article-title":"Baclofen acts in the central amygdala to reduce synaptic transmission and impair context fear conditioning","volume":"8","author":"Delaney","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2019.02.001_bib0315","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1210\/en.2017-03176","article-title":"Enhanced hypothalamic NMDA receptor activity contributes to hyperactivity of HPA axis in chronic stress in male rats","volume":"159","author":"Zhou","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0320","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000122400","article-title":"Effect of intraventricular glutamate on ACTH release","volume":"18","author":"Makara","year":"1975","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0325","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1523\/JNEUROSCI.22-03-00959.2002","article-title":"Neurotransmitter regulation of cellular activation and neuropeptide gene expression in the paraventricular nucleus of the hypothalamus","volume":"22","author":"Cole","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0330","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/cne.22142","article-title":"Chronic stress-induced neurotransmitter plasticity in the PVN","volume":"517","author":"Flak","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0335","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1111\/ejn.12587","article-title":"Role of paraventricular nucleus-projecting norepinephrine\/epinephrine neurons in acute and chronic stress","volume":"39","author":"Flak","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0340","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.psychres.2016.05.013","article-title":"Is plasma GABA level a biomarker of Post-Traumatic Stress Disorder (PTSD) severity? A preliminary study","volume":"241","author":"Trousselard","year":"2016","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0345","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1176\/ajp.2006.163.8.1446","article-title":"Relationship between posttrauma GABA plasma levels and PTSD at 1-year follow-up","volume":"163","author":"Vaiva","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0350","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.biopsych.2003.08.009","article-title":"Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder","volume":"55","author":"Vaiva","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0355","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jpsychires.2006.11.009","article-title":"Elevated plasma arginine vasopressin levels in veterans with posttraumatic stress disorder","volume":"42","author":"de Kloet","year":"2008","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0360","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0024-3205(98)00232-X","article-title":"Increased expression of magnocellular arginine vasopressin mRNA in paraventricular nucleus of stress-induced depression-model rats","volume":"63","author":"Nakase","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0365","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1172\/JCI113382","article-title":"Vasopressin stimulation of adrenocorticotropin hormone (ACTH) in humans. In vivo bioassay of corticotropin-releasing factor (CRF) which provides evidence for CRF mediation of the diurnal rhythm of ACTH","volume":"81","author":"Salata","year":"1988","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.phrs.2019.02.001_bib0370","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0006-8993(97)01159-1","article-title":"Stress increases oxytocin release within the hypothalamic paraventricular nucleus","volume":"781","author":"Nishioka","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0375","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0306-4522(97)00683-0","article-title":"Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: new insights into the secretory capacities of peptidergic neurons","volume":"85","author":"Wotjak","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2019.02.001_bib0380","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2826.2000.00442.x","article-title":"Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo\u2013pituitary\u2013adrenal axis in male and female rats: partial action within the paraventricular nucleus","volume":"12","author":"Neumann","year":"2000","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0385","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1210\/en.2018-00217","article-title":"Chronic variable stress induces sex-specific alterations in social behavior and neuropeptide expression in the mouse","volume":"159","author":"Borrow","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0390","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1016\/j.celrep.2017.03.004","article-title":"Single-cell RNA-Seq reveals hypothalamic cell diversity","volume":"18","author":"Chen","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.phrs.2019.02.001_bib0395","doi-asserted-by":"crossref","first-page":"e12532","DOI":"10.1111\/jne.12532","article-title":"Regulation of hypothalamic corticotropin-releasing hormone neurone excitability by oxytocin","volume":"29","author":"Jamieson","year":"2017","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0400","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainres.2011.02.091","article-title":"Hypothalamic oxytocin attenuates CRF expression via GABA(A) receptors in rats","volume":"1387","author":"B\u00fclb\u00fcl","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0405","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.psyneuen.2015.09.017","article-title":"Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus","volume":"63","author":"Smith","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0410","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1210\/endo.138.7.5255","article-title":"Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats","volume":"138","author":"Windle","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0415","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123848","article-title":"Effects of oxytocin on fear memory and neuroinflammation in a rodent model of posttraumatic stress disorder","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0420","article-title":"Effects of intranasal oxytocin on distraction as emotion regulation strategy in patients with post-traumatic stress disorder","author":"Koch","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0425","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jpsychires.2017.12.014","article-title":"Augmenting prolonged exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial","volume":"98","author":"Flanagan","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0430","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jpsychires.2017.06.010","article-title":"Individual variation in plasma oxytocin and vasopressin levels in relation to the development of combat-related PTSD in a large military cohort","volume":"94","author":"Reijnen","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0435","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/jne.12300","article-title":"Salivary oxytocin and vasopressin levels in police officers with and without post-traumatic stress disorder","volume":"27","author":"Frijling","year":"2015","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0440","article-title":"Oxytocin receptor gene methylation in male and female PTSD patients and trauma-exposed controls","author":"Nawijn","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0445","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.brainres.2005.12.100","article-title":"Mesocortical dopamine and HPA axis regulation: role of laterality and early environment","volume":"1076","author":"Sullivan","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0450","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.1226767","article-title":"Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons","volume":"339","author":"Barik","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.phrs.2019.02.001_bib0455","first-page":"2299","article-title":"Regulation of intermediate pituitary corticotropin-releasing hormone receptors by dopamine","volume":"130","author":"Shiver","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0460","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.neuron.2015.09.001","article-title":"Dopamine regulation of amygdala inhibitory circuits for expression of learned fear","volume":"88","author":"Kwon","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2019.02.001_bib0465","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/JCP.0b013e318032eaed","article-title":"A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder","volume":"27","author":"Becker","year":"2007","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0470","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/1099-1077(200006)15:4<295::AID-HUP166>3.0.CO;2-O","article-title":"The use of stimulants in the treatment of post traumatic stress disorder: case report","volume":"15","author":"Daly","year":"2000","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0475","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1177\/0269881110385600","article-title":"Psychostimulant treatment of combat-related posttraumatic stress disorder","volume":"25","author":"Houlihan","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0480","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S2215-0366(18)30135-4","article-title":"3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial","volume":"5","author":"Mithoefer","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0485","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pnpbp.2013.09.021","article-title":"Behavioral and neurochemical effects of repeated MDMA administration during late adolescence in the rat","volume":"48","author":"Cox","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0490","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4161\/cib.2.3.7825","article-title":"Neuregulin links dopaminergic and glutamatergic neurotransmission to control hippocampal synaptic plasticity","volume":"2","author":"Neddens","year":"2009","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0495","doi-asserted-by":"crossref","first-page":"15587","DOI":"10.1073\/pnas.0805722105","article-title":"Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors","volume":"105","author":"Bin Kwon","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib0500","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.neuron.2007.04.009","article-title":"Neuregulin-1 enhances depolarization-induced GABA release","volume":"54","author":"Woo","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2019.02.001_bib0505","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/npp.2014.274","article-title":"Amygdala NRG1\u2013ErbB4 is critical for the modulation of anxiety-like behaviors","volume":"40","author":"Bi","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0510","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/0269881116655979","article-title":"A functional neuregulin-1 gene variant and stressful life events: effect on drug use in a longitudinal population-representative cohort study","volume":"31","author":"Vaht","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0515","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.physbeh.2010.11.015","article-title":"Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli","volume":"104","author":"Taylor","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.phrs.2019.02.001_bib0520","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/j.1471-4159.2011.07284.x","article-title":"Systemic administration of neuregulin-1\u03b21 protects dopaminergic neurons in a mouse model of Parkinson's disease","volume":"117","author":"Carlsson","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2019.02.001_bib0525","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2014.12.024","article-title":"Level of plasma neuregulin-1 SMDF is reduced in patients with idiopathic Parkinson's disease","volume":"587","author":"Hama","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2019.02.001_bib0530","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pnpbp.2018.11.018","article-title":"Elevated cleavage of neuregulin-1 by beta-secretase 1 in plasma of schizophrenia patients","volume":"90","author":"Zhang","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0535","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2005.01.090","article-title":"Glutamatergic innervation of corticotropin-releasing hormone- and thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat","volume":"1039","author":"Wittmann","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0540","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.neuroscience.2006.10.053","article-title":"Glutamatergic innervation of the hypothalamic median eminence and posterior pituitary of the rat","volume":"144","author":"Hrabovszky","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2019.02.001_bib0545","doi-asserted-by":"crossref","DOI":"10.1210\/en.2017-03176","article-title":"Enhanced hypothalamic NMDA receptor activity contributes to hyperactivity of HPA axis in chronic stress in male rats","author":"Zhou","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0550","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/cne.20445","article-title":"Organization and regulation of paraventricular nucleus glutamate signaling systems: N-methyl-d-aspartate receptors","volume":"484","author":"Ziegler","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/934162","article-title":"An open-label trial of memantine for cognitive impairment in patients with posttraumatic stress disorder","volume":"2015","author":"Ramaswamy","year":"2015","journal-title":"J. Aging Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0560","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00213-017-4786-3","article-title":"Impact of oral ketamine augmentation on hospital admissions in treatment-resistant depression and PTSD: a retrospective study","volume":"235","author":"Hartberg","year":"2017","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2019.02.001_bib0565","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.17464","article-title":"Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval","volume":"5","author":"Ishikawa","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.phrs.2019.02.001_bib0570","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.bbr.2018.03.037","article-title":"d-Cycloserine facilitates reversal in an animal model of post-traumatic stress disorder","volume":"347","author":"George","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0575","doi-asserted-by":"crossref","first-page":"88","DOI":"10.9740\/mhc.2017.03.088","article-title":"d-Cycloserine in the treatment of posttraumatic stress disorder","volume":"7","author":"Baker","year":"2018","journal-title":"Ment. Health Clin."},{"key":"10.1016\/j.phrs.2019.02.001_bib0580","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s12035-011-8203-3","article-title":"The cochlear CRF signaling systems and their mechanisms of action in modulating cochlear sensitivity and protection against trauma","volume":"44","author":"Graham","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0585","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1210\/en.2007-0319","article-title":"Hypothalamic\u2013pituitary\u2013adrenal axis hyporesponsiveness to restraint stress in mice deficient for large-conductance calcium- and voltage-activated potassium (BK) channels","volume":"148","author":"Brunton","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0590","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10571-017-0517-x","article-title":"Posttraumatic stress disorder disturbs coronary tone and its regulatory mechanisms","volume":"38","author":"Lazuko","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0595","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fnbeh.2014.00096","article-title":"Modulating fear extinction memory by manipulating SK potassium channels in the infralimbic cortex","volume":"8","author":"Criado-Marrero","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0600","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/j.2040-4603.2014.tb00585.x","article-title":"Hypothalamic\u2013pituitary\u2013adrenal (HPA) axis and aging","volume":"4","author":"Gupta","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0605","doi-asserted-by":"crossref","first-page":"e1501723","DOI":"10.1126\/sciadv.1501723","article-title":"A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence","volume":"2","author":"Kakizawa","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phrs.2019.02.001_bib0610","doi-asserted-by":"crossref","first-page":"11188","DOI":"10.1523\/JNEUROSCI.1046-10.2010","article-title":"Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus","volume":"30","author":"Wamsteeker","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0615","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.copsyc.2016.12.001","article-title":"Cannabinoids as therapeutic for PTSD","volume":"14","author":"Loflin","year":"2017","journal-title":"Curr. Opin. Psychol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0620","doi-asserted-by":"crossref","first-page":"86","DOI":"10.9740\/mhc.2018.03.086","article-title":"A review of medical marijuana for the treatment of posttraumatic stress disorder: real symptom re-leaf or just high hopes?","volume":"8","author":"Shishko","year":"2018","journal-title":"Ment. Health Clin."},{"key":"10.1016\/j.phrs.2019.02.001_bib0625","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrn1703","article-title":"Neurosteroids: endogenous regulators of the GABAA receptor","volume":"6","author":"Belelli","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0630","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.biopsych.2006.03.026","article-title":"Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder","volume":"60","author":"Rasmusson","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0635","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.biopsych.2012.12.008","article-title":"Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits","volume":"73","author":"Sripada","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0640","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1460-9568.2002.02084.x","article-title":"The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens","volume":"16","author":"Roug\u00e9-Pont","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0645","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroscience.2011.03.061","article-title":"Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons","volume":"191","author":"B\u00e4ckstr\u00f6m","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2019.02.001_bib0650","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000339822","article-title":"Membrane progesterone receptors: evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cells","volume":"96","author":"Thomas","year":"2012","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0655","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.1175055","article-title":"Translocator protein (18\u202fkD) as target for anxiolytics without benzodiazepine-like side effects","volume":"325","author":"Rupprecht","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.phrs.2019.02.001_bib0660","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fphar.2013.00166","article-title":"Targeting neurosteroidogenesis as therapy for PTSD","volume":"4","author":"Pinna","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0665","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12325-015-0176-6","article-title":"Etifoxine versus alprazolam for the treatment of adjustment disorder with anxiety: a randomized controlled trial","volume":"32","author":"Stein","year":"2015","journal-title":"Adv. Ther."},{"key":"10.1016\/j.phrs.2019.02.001_bib0670","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1177\/0269881115625115","article-title":"Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216","volume":"30","author":"Zhang","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0675","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.nlm.2014.10.001","article-title":"Low levels of estradiol are associated with elevated conditioned responding during fear extinction and with intrusive memories in daily life","volume":"116","author":"Wegerer","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.phrs.2019.02.001_bib0680","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.psyneuen.2017.10.006","article-title":"Neural activity during traumatic film viewing is linked to endogenous estradiol and hormonal contraception","volume":"87","author":"Miedl","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0685","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1006\/bbrc.1998.8177","article-title":"Modulation of GABA-gated chloride ion influx in the brain by dehydroepiandrosterone and its metabolites","volume":"243","author":"Imamura","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2019.02.001_bib0690","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.psyneuen.2017.06.010","article-title":"DHEA and DHEA-S levels in posttraumatic stress disorder: a meta-analytic review","volume":"84","author":"van Zuiden","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0695","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1002\/hbm.22399","article-title":"The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity","volume":"35","author":"Sripada","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.phrs.2019.02.001_bib0700","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1037\/a0018113","article-title":"Intrusive images in psychological disorders: characteristics, neural mechanisms, and treatment implications","volume":"117","author":"Brewin","year":"2010","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.phrs.2019.02.001_bib0705","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1101\/lm.1.1.34","article-title":"Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning","volume":"1","author":"Phillips","year":"1994","journal-title":"Learn. Mem."},{"key":"10.1016\/j.phrs.2019.02.001_bib0710","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1037\/0735-7044.112.4.863","article-title":"The dorsal hippocampus is essential for context discrimination but not for contextual conditioning","volume":"112","author":"Frankland","year":"1998","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0715","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1196\/annals.1314.012","article-title":"Neuroanatomical changes associated with pharmacotherapy in posttraumatic stress disorder","volume":"1032","author":"Bremner","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0720","doi-asserted-by":"crossref","first-page":"717958","DOI":"10.1155\/2015\/717958","article-title":"Involvement of adult hippocampal neurogenesis in learning and forgetting","volume":"2015","author":"Yau","year":"2015","journal-title":"Neural Plast."},{"key":"10.1016\/j.phrs.2019.02.001_bib0725","doi-asserted-by":"crossref","first-page":"14731","DOI":"10.1073\/pnas.97.26.14731","article-title":"Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin 1A receptors","volume":"97","author":"Sarnyai","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib0730","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.nucmedbio.2007.06.008","article-title":"Serotonin-1A receptor imaging in recurrent depression: replication and literature review","volume":"34","author":"Drevets","year":"2007","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0735","doi-asserted-by":"crossref","first-page":"13512","DOI":"10.1073\/pnas.96.23.13512","article-title":"Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes","volume":"96","author":"Griffin","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib0740","article-title":"Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials","volume":"358","author":"Batelaan","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2019.02.001_bib0745","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2019.02.001_bib0750","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/nn958","article-title":"Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma","volume":"5","author":"Gilbertson","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0755","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.biopsych.2017.09.006","article-title":"Smaller hippocampal volume in posttraumatic stress disorder: a multisite ENIGMA-PGC study: subcortical volumetry results from posttraumatic stress disorder consortia","volume":"83","author":"Logue","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0760","article-title":"The association of PTSD symptom severity with localized hippocampus and amygdala abnormalities","volume":"1","author":"Akiki","year":"2017","journal-title":"Chronic Stress (Thousand Oaks, Calif.)"},{"key":"10.1016\/j.phrs.2019.02.001_bib0765","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.neuropharm.2011.04.029","article-title":"Hippocampal dysfunction effects on context memory: possible etiology for posttraumatic stress disorder","volume":"62","author":"Acheson","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0770","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.yfrne.2007.10.002","article-title":"Corticosteroid hormones in the central stress response: quick-and-slow","volume":"29","author":"de Kloet","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0775","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/hipo.450020409","article-title":"Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation","volume":"2","author":"Diamond","year":"1992","journal-title":"Hippocampus"},{"key":"10.1016\/j.phrs.2019.02.001_bib0780","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1530\/JOE-10-0472","article-title":"Rapid non-genomic effects of corticosteroids and their role in the central stress response","volume":"209","author":"Groeneweg","year":"2011","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0785","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0022-3956(01)00018-8","article-title":"Corticosteroids and cognition","volume":"35","author":"Belanoff","year":"2001","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0790","doi-asserted-by":"crossref","first-page":"e30481","DOI":"10.1371\/journal.pone.0030481","article-title":"Stress leads to contrasting effects on the levels of brain derived neurotrophic factor in the hippocampus and amygdala","volume":"7","author":"Lakshminarasimhan","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2019.02.001_bib0795","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/nn.3266","article-title":"Glucocorticoid receptors recruit the CaMKII\u03b1-BDNF-CREB pathways to mediate memory consolidation","volume":"15","author":"Chen","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0800","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2007.09.017","article-title":"Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking","volume":"131","author":"Hu","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2019.02.001_bib0805","first-page":"1","article-title":"Contextual fear extinction induces hippocampal metaplasticity mediated by metabotropic glutamate receptor 5","author":"Stansley","year":"2017","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.phrs.2019.02.001_bib0810","doi-asserted-by":"crossref","first-page":"8390","DOI":"10.1073\/pnas.1701749114","article-title":"Altered metabotropic glutamate receptor 5 markers in PTSD: in vivo and postmortem evidence","volume":"114","author":"Holmes","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib0815","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/S0028-3908(00)00037-X","article-title":"Fear conditioning-induced time- and subregion-specific increase in expression of mGlu5 receptor protein in rat hippocampus","volume":"39","author":"Riedel","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0820","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1523\/JNEUROSCI.1519-16.2016","article-title":"Activation of group II metabotropic glutamate receptors promotes LTP induction at Schaffer collateral-CA1 pyramidal cell synapses by priming NMDA receptors","volume":"36","author":"Rosenberg","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0825","doi-asserted-by":"crossref","first-page":"e0159192","DOI":"10.1371\/journal.pone.0159192","article-title":"Ketamine protects gamma oscillations by inhibiting hippocampal LTD","volume":"11","author":"Huang","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.phrs.2019.02.001_bib0830","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00213-017-4793-4","article-title":"Psychedelics and reconsolidation of traumatic and appetitive maladaptive memories: focus on cannabinoids and ketamine","volume":"235","author":"Fattore","year":"2017","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2019.02.001_bib0835","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbr.2017.03.027","article-title":"Extinction memory is facilitated by methylphenidate and regulated by dopamine and noradrenaline receptors","volume":"326","author":"Furini","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0840","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/npp.2017.305","article-title":"Enhancing endocannabinoid neurotransmission augments the efficacy of extinction training and ameliorates traumatic stress-induced behavioral alterations in rats","volume":"43","author":"Morena","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0845","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1038\/s41386-018-0135-4","article-title":"Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity","volume":"43","author":"Segev","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0850","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.euroneuro.2018.02.004","article-title":"Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD","volume":"28","author":"Fidelman","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0855","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/mp.2013.61","article-title":"Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study","volume":"18","author":"Neumeister","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0860","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/npp.2017.162","article-title":"Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder","volume":"43","author":"Hill","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0865","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1007\/s00429-015-1056-1","article-title":"Stress, trauma and PTSD: translational insights into the core synaptic circuitry and its modulation","volume":"221","author":"Bennett","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.phrs.2019.02.001_bib0870","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/da.22478","article-title":"Aberrant resting-state brain activity in posttraumatic stress disorder: a meta-analysis and systematic review","volume":"33","author":"Koch","year":"2016","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.phrs.2019.02.001_bib0875","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1101\/lm.044412.116","article-title":"Characterization of the amplificatory effect of norepinephrine in the acquisition of Pavlovian threat associations","volume":"24","author":"D\u00edaz-Mataix","year":"2017","journal-title":"Learn. Mem."},{"key":"10.1016\/j.phrs.2019.02.001_bib0880","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/jnr.22592","article-title":"Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala","volume":"89","author":"Izumi","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0885","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1523\/JNEUROSCI.0680-07.2007","article-title":"Glucocorticoids enhance the excitability of principal basolateral amygdala neurons","volume":"27","author":"Duvarci","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0890","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1038\/npp.2015.76","article-title":"Alteration of the centromedial amygdala glutamatergic synapses by the BDNF Val66Met polymorphism","volume":"40","author":"Galvin","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0895","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.conb.2006.07.004","article-title":"Prefrontal involvement in the regulation of emotion: convergence of rat and human studies","volume":"16","author":"Quirk","year":"2006","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0900","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.neuroimage.2005.03.047","article-title":"Trauma modulates amygdala and medial prefrontal responses to consciously attended fear","volume":"29","author":"Williams","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.phrs.2019.02.001_bib0905","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1096-9861(19980525)395:1<53::AID-CNE5>3.0.CO;2-G","article-title":"Intrinsic connections of the rat amygdaloid complex: projections originating in the central nucleus","volume":"395","author":"Jolkkonen","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0910","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/jnr.23690","article-title":"The basolateral amygdala \u03b3-aminobutyric acidergic system in health and disease","volume":"94","author":"Prager","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0915","doi-asserted-by":"crossref","first-page":"e94666","DOI":"10.1371\/journal.pone.0094666","article-title":"Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the amygdala","volume":"9","author":"Tzanoulinou","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.phrs.2019.02.001_bib0920","doi-asserted-by":"crossref","first-page":"12387","DOI":"10.1523\/JNEUROSCI.4316-06.2006","article-title":"Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning","volume":"26","author":"Wilensky","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0925","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/mp.2008.81","article-title":"Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults","volume":"14","author":"Nelson","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0930","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.11.011","article-title":"Behavioral insights from mouse models of forebrain \u2013 and amygdala-specific glucocorticoid receptor genetic disruption","volume":"336","author":"Arnett","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0935","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1152\/jn.1991.66.3.999","article-title":"Inhibitory transmission in the basolateral amygdala","volume":"66","author":"Rainnie","year":"1991","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0940","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/mp.2016.87","article-title":"Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor","volume":"22","author":"Hartmann","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib0945","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3389\/fphar.2017.00921","article-title":"Dual influence of endocannabinoids on long-term potentiation of synaptic transmission","volume":"8","author":"Silva-Cruz","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0950","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.psyneuen.2010.03.005","article-title":"Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo","volume":"35","author":"Hill","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0955","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.euroneuro.2017.06.006","article-title":"The effects of enhancing endocannabinoid signaling and blocking corticotrophin releasing factor receptor in the amygdala and hippocampus on the consolidation of a stressful event","volume":"27","author":"Aisenberg","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib0960","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.brainres.2006.09.078","article-title":"The NMDA receptor antagonist CPP blocks the effects of predator stress on pCREB in brain regions involved in fearful and anxious behavior","volume":"1136","author":"Blundell","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0965","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0306-4522(01)00380-3","article-title":"Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: high concentrations in a subpopulation of cholecystokinin-containing interneurons","volume":"107","author":"McDonald","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2019.02.001_bib0970","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.psyneuen.2014.11.002","article-title":"The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: a preliminary randomized, double-blind, placebo-controlled cross-over design study","volume":"51","author":"Jetly","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib0975","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.nlm.2017.08.004","article-title":"The effects of cannabinoid receptors activation and glucocorticoid receptors deactivation in the amygdala and hippocampus on the consolidation of a traumatic event","volume":"144","author":"Shoshan","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.phrs.2019.02.001_bib0980","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.phrs.2016.07.024","article-title":"The endocannabinoid system and Post Traumatic Stress Disorder (PTSD): from preclinical findings to innovative therapeutic approaches in clinical settings","volume":"111","author":"Berardi","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0985","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.brainres.2004.05.053","article-title":"Immunocytochemical localization of GABABR1 receptor subunits in the basolateral amygdala","volume":"1018","author":"McDonald","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib0990","doi-asserted-by":"crossref","first-page":"11027","DOI":"10.1523\/JNEUROSCI.19-24-11027.1999","article-title":"Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo","volume":"19","author":"Rosenkranz","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib0995","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.10.045","article-title":"Distribution of dopamine D2-like receptors in the rat amygdala and their role in the modulation of unconditioned fear and anxiety","volume":"201","author":"de la Mora","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2019.02.001_bib1000","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.neuron.2012.02.015","article-title":"GABA neurons of the VTA drive conditioned place aversion","volume":"73","author":"Tan","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2019.02.001_bib1005","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.neuropharm.2008.09.005","article-title":"Involvement of dopamine D2 receptors in the induction of long-term potentiation in the basolateral amygdala\u2013dentate gyrus pathway of anesthetized rats","volume":"55","author":"Abe","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1010","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/npp.2010.246","article-title":"Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral\/basolateral amygdala","volume":"36","author":"Diaz","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1015","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1177\/0269881111405556","article-title":"D1 and D2 dopaminergic systems in the rat basolateral amygdala are involved in anxiogenic-like effects induced by histamine","volume":"26","author":"Bananej","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/0269881110376688","article-title":"Anxiolytic-like effect induced by the cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA), in the rat amygdala is mediated through the D1 and D2 dopaminergic systems","volume":"25","author":"Zarrindast","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1025","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.brainres.2008.02.009","article-title":"Dopamine receptor gene expression in human amygdaloid nuclei: elevated D4 receptor mRNA in major depression","volume":"1207","author":"Xiang","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1030","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/1098-2396(20001201)38:3<328::AID-SYN12>3.0.CO;2-T","article-title":"5-HT(1A) receptor-mediated inhibition and 5-HT(2) as well as 5-HT(3) receptor-mediated excitation in different subdivisions of the rat amygdala","volume":"38","author":"Stein","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.phrs.2019.02.001_bib1035","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.biopsych.2015.06.025","article-title":"Stress enables reinforcement-elicited serotonergic consolidation of fear memory","volume":"79","author":"Baratta","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1040","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/bjhp.12109","article-title":"Intrusive memories of hallucinations and delusions in traumatized intensive care patients: an interview study","volume":"20","author":"Wade","year":"2015","journal-title":"Br. J. Health Psychol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1045","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature06612","article-title":"Identification of a serotonin\/glutamate receptor complex implicated in psychosis","volume":"452","author":"Gonz\u00e1lez-Maeso","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2019.02.001_bib1050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pbb.2007.10.016","article-title":"Activation of the serotonin 5-HT2C receptor is involved in the enhanced anxiety in rats after single-prolonged stress","volume":"89","author":"Harada","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2019.02.001_bib1055","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neuroscience.2007.01.047","article-title":"Neuronal localization of 5-HT type 2A receptor immunoreactivity in the rat basolateral amygdala","volume":"146","author":"McDonald","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2019.02.001_bib1060","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00213-015-4194-5","article-title":"Escitalopram reversed the traumatic stress-induced depressed and anxiety-like symptoms but not the deficits of fear memory","volume":"233","author":"Lin","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2019.02.001_bib1065","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.1214592","article-title":"Fear erasure in mice requires synergy between antidepressant drugs and extinction training","volume":"334","author":"Karpova","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.phrs.2019.02.001_bib1070","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/npp.2011.318","article-title":"BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity","volume":"37","author":"Bath","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.npp.1300297","article-title":"Stress impairs \u03b11A adrenoceptor-mediated noradrenergic facilitation of GABAergic transmission in the basolateral amygdala","volume":"29","author":"Braga","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1080","doi-asserted-by":"crossref","first-page":"12358","DOI":"10.1523\/JNEUROSCI.2007-07.2007","article-title":"Noradrenergic modulation of basolateral amygdala neuronal activity: opposing influences of alpha-2 and beta receptor activation","volume":"27","author":"Buffalari","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1085","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0006-8993(98)00795-1","article-title":"Norepinephrine release in the amygdala in response to footshock and opioid peptidergic drugs","volume":"808","author":"Quirarte","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1090","doi-asserted-by":"crossref","first-page":"E5584","DOI":"10.1073\/pnas.1421304111","article-title":"Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation","volume":"111","author":"Johansen","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib1095","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1176\/appi.ajp.2017.17050481","article-title":"Reduction of PTSD symptoms with pre-reactivation propranolol therapy: a randomized controlled trial","volume":"175","author":"Brunet","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1100","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1523\/JNEUROSCI.2706-14.2015","article-title":"Impact of basal forebrain cholinergic inputs on basolateral amygdala neurons","volume":"35","author":"Unal","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1105","article-title":"Cotinine: a therapy for memory extinction in post-traumatic stress disorder","author":"Mendoza","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1110","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1152\/jn.01030.2012","article-title":"\u03b17-Containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability","volume":"110","author":"Pidoplichko","year":"2013","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1115","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/npp.2015.282","article-title":"Randomized placebo-controlled trial of methylphenidate or galantamine for persistent emotional and cognitive symptoms associated with PTSD and\/or traumatic brain injury","volume":"41","author":"McAllister","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1120","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/JCP.0000000000000624","article-title":"Effect of rivastigmine augmentation in treatment of male patients with combat-related chronic posttraumatic stress disorder","volume":"37","author":"Rezaei Ardani","year":"2017","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1125","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.neuron.2017.03.022","article-title":"Synaptic plasticity, engrams, and network oscillations in amygdala circuits for storage and retrieval of emotional memories","volume":"94","author":"Bocchio","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2019.02.001_bib1130","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/29312","article-title":"Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala","volume":"394","author":"Mahanty","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2019.02.001_bib1135","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/sj.mp.4002054","article-title":"Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder","volume":"13","author":"Geuze","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroscience.2012.07.006","article-title":"Presynaptic facilitation of glutamate release in the basolateral amygdala: a mechanism for the anxiogenic and seizurogenic function of GluK1 receptors","volume":"221","author":"Aroniadou-Anderjaska","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2019.02.001_bib1145","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/npp.2013.317","article-title":"d-Cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial","volume":"39","author":"Difede","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/cercor\/bhn076","article-title":"The NMDA agonist d-cycloserine facilitates fear memory consolidation in humans","volume":"19","author":"Kalisch","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.phrs.2019.02.001_bib1155","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/jamapsychiatry.2014.62","article-title":"Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder","volume":"71","author":"Feder","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1160","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.eurpsy.2013.10.005","article-title":"Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex","volume":"29","author":"Zhou","year":"2014","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1165","doi-asserted-by":"crossref","first-page":"14075","DOI":"10.1073\/pnas.0906791106","article-title":"Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory","volume":"106","author":"Yuen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib1170","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1126\/science.1171203","article-title":"Chronic stress causes frontostriatal reorganization and affects decision-making","volume":"325","author":"Dias-Ferreira","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.phrs.2019.02.001_bib1175","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1101\/lm.1474609","article-title":"Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction","volume":"16","author":"Laurent","year":"2009","journal-title":"Learn. Mem."},{"key":"10.1016\/j.phrs.2019.02.001_bib1180","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00213-007-0758-3","article-title":"In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2\/3 receptor agonist LY404039 in animal models of psychiatric disorders","volume":"193","author":"Rorick-Kehn","year":"2007","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2019.02.001_bib1185","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrn3339","article-title":"Biological studies of post-traumatic stress disorder","volume":"13","author":"Pitman","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1190","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jpsychires.2013.01.023","article-title":"Effect of traumatic imagery on cerebrospinal fluid dopamine and serotonin metabolites in posttraumatic stress disorder","volume":"47","author":"Geracioti","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1195","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/S0006-3223(99)00138-9","article-title":"A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex","volume":"46","author":"Birnbaum","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1200","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1056\/NEJMoa1507598","article-title":"Trial of prazosin for post-traumatic stress disorder in military veterans","volume":"378","author":"Raskind","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2019.02.001_bib1205","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neubiorev.2014.02.006","article-title":"A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior","volume":"42","author":"McLaughlin","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phrs.2019.02.001_bib1210","article-title":"Prefrontal endocannabinoids, stress controllability and resilience: a hypothesis","author":"Worley","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1215","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/FBP.0000000000000253","article-title":"Cannabinoids and post-traumatic stress disorder","volume":"27","author":"Mizrachi Zer-Aviv","year":"2016","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1220","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1176\/appi.ajp.157.7.1120","article-title":"Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder","volume":"157","author":"Bremner","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1225","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0006-3223(02)01788-2","article-title":"Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECT","volume":"54","author":"Kugaya","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1230","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1523\/JNEUROSCI.1395-14.2014","article-title":"Early adolescent MK-801 exposure impairs the maturation of ventral hippocampal control of basolateral amygdala drive in the adult prefrontal cortex","volume":"34","author":"Thomases","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1235","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biopsych.2017.08.021","article-title":"Locus coeruleus activity mediates hyperresponsiveness in posttraumatic stress disorder","volume":"83","author":"Naegeli","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1240","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12031-017-0911-3","article-title":"Possible reversal of PTSD-related DNA methylation by sympathetic blockade","volume":"62","author":"Lipov","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1245","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s11064-013-1076-2","article-title":"Increased noradrenaline levels in the rostral pons can be reversed by M1 antagonist in a rat model of post-traumatic stress disorder","volume":"38","author":"Terzio\u011flu","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1250","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2017.04.006","article-title":"Comparison of pro-amnesic efficacy of scopolamine, biperiden, and phencyclidine by using passive avoidance task in CD-1 mice","volume":"86","author":"Malikowska","year":"2017","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.phrs.2019.02.001_bib1255","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1101\/lm.326906","article-title":"Aversive memory reactivation engages in the amygdala only some neurotransmitters involved in consolidation","volume":"13","author":"Bucherelli","year":"2006","journal-title":"Learn. Mem."},{"key":"10.1016\/j.phrs.2019.02.001_bib1260","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1037\/1064-1297.15.2.154","article-title":"The effect of nicotine and attention allocation on physiological and self-report measures of induced anxiety in PTSD: a double-blind placebo-controlled trial","volume":"15","author":"Buckley","year":"2007","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1265","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1037\/a0033966","article-title":"The effects of nicotine on intrusive memories in nonsmokers","volume":"21","author":"Hawkins","year":"2013","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1270","doi-asserted-by":"crossref","first-page":"263","DOI":"10.31887\/DCNS.2011.13.2\/jsherin","article-title":"Post-traumatic stress disorder: the neurobiological impact of psychological trauma","volume":"13","author":"Sherin","year":"2011","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1275","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1038\/npp.2012.50","article-title":"Corticotropin-releasing factor acting at the locus coeruleus disrupts thalamic and cortical sensory-evoked responses","volume":"37","author":"Devilbiss","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1280","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/jnc.13347","article-title":"Locus coeruleus response to single-prolonged stress and early intervention with intranasal neuropeptide Y","volume":"135","author":"Sabban","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2019.02.001_bib1285","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0893-133X(97)00199-1","article-title":"Plasma neuropeptide Y (NPY) increases in humans in response to the \u03b12 antagonist yohimbine","volume":"19","author":"Rasmusson","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1290","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.expneurol.2016.06.020","article-title":"Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): a translational update","volume":"284","author":"Schmeltzer","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1295","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ijnp\/pyx109","article-title":"A Randomized dose-ranging study of neuropeptide y in patients with posttraumatic stress disorder","volume":"21","author":"Sayed","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1300","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.brainres.2015.11.021","article-title":"Sex differences in the locus coeruleus\u2013norepinephrine system and its regulation by stress","volume":"1641","author":"Bangasser","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1305","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/ejn.12095","article-title":"Altered locus coeruleus\u2013norepinephrine function following single prolonged stress","volume":"37","author":"George","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1310","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1176\/jnp.17.4.503","article-title":"Postmortem locus coeruleus neuron count in three American veterans with probable or possible war-related PTSD","volume":"17","author":"Bracha","year":"2005","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1315","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0165-1781(98)00002-X","article-title":"Plasma dopamine beta-hydroxylase activity in psychotic and non-psychotic post-traumatic stress disorder","volume":"77","author":"Hamner","year":"1998","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1320","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/ajmg.b.30526","article-title":"Dopamine beta-hydroxylase (DBH) activity and -1021C\/T polymorphism ofDBH gene in combat-related post-traumatic stress disorder","volume":"144B","author":"Mustapi\u0107","year":"2007","journal-title":"Am. J. Med. Genet. Part B: Neuropsychiatr. Genet."},{"key":"10.1016\/j.phrs.2019.02.001_bib1325","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1001\/jamapsychiatry.2013.399","article-title":"Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus","volume":"70","author":"Pietrzak","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1330","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1038\/npp.2011.47","article-title":"Pharmacological stimulation of locus coeruleus reveals a new antipsychotic-responsive pathway for deficient sensorimotor gating","volume":"36","author":"Alsene","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1335","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/2045125313500982","article-title":"High-dose prazosin for the treatment of post-traumatic stress disorder","volume":"4","author":"Koola","year":"2014","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1340","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/JCP.0b013e31819a4bae","article-title":"Clonidine improves hyperarousal in borderline personality disorder with or without comorbid posttraumatic stress disorder","volume":"29","author":"Ziegenhorn","year":"2009","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1345","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1139\/y81-007","article-title":"Cyclobenzaprine: a possible mechanism of action for its muscle relaxant effect","volume":"59","author":"Commissiong","year":"1981","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1350","doi-asserted-by":"crossref","first-page":"11178","DOI":"10.1073\/pnas.1204524109","article-title":"Identifying mechanism-of-action targets for drugs and probes","volume":"109","author":"Gregori-Puigjane","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib1355","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/s41467-017-01782-z","article-title":"Orexin modulates behavioral fear expression through the locus coeruleus","volume":"8","author":"Soya","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2019.02.001_bib1360","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/ana.21881","article-title":"Reduced amygdala activity during aversive conditioning in human narcolepsy","volume":"67","author":"Ponz","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1365","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.psyneuen.2010.01.001","article-title":"Low cerebrospinal fluid and plasma orexin-A (hypocretin-1) concentrations in combat-related posttraumatic stress disorder","volume":"35","author":"Strawn","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1370","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00213-012-2736-7","article-title":"The brain orexin system and almorexant in fear-conditioned startle reactions in the rat","volume":"223","author":"Steiner","year":"2012","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2019.02.001_bib1375","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbr.2012.12.064","article-title":"Orexin-1 receptor antagonism fails to reduce anxiety-like behaviour in either plus-maze-na\u00efve or plus-maze-experienced mice","volume":"243","author":"Rodgers","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1380","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1212\/WNL.0b013e31827688ee","article-title":"Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant","volume":"79","author":"Herring","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1385","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1517\/13543784.16.11.1785","article-title":"The hypocretin\/orexin receptor: therapeutic prospective in sleep disorders","volume":"16","author":"Nishino","year":"2007","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.phrs.2019.02.001_bib1390","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/1097-4547(20001015)62:2<161::AID-JNR1>3.0.CO;2-1","article-title":"The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding","volume":"62","author":"Sutcliffe","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1395","doi-asserted-by":"crossref","DOI":"10.1186\/s13587-015-0018-9","article-title":"Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory","volume":"5","author":"Pace-Schott","year":"2015","journal-title":"Biol. Mood Anxiety Disord."},{"key":"10.1016\/j.phrs.2019.02.001_bib1400","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/cne.23969","article-title":"The cross-mammalian neurophenomenology of primal emotional affects: from animal feelings to human therapeutics","volume":"524","author":"Panksepp","year":"2016","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1405","doi-asserted-by":"crossref","first-page":"20160206","DOI":"10.1098\/rstb.2016.0206","article-title":"Freeze for action: neurobiological mechanisms in animal and human freezing","volume":"372","author":"Roelofs","year":"2017","journal-title":"Philos. Trans. R. Soc. B: Biol. Sci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1410","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbr.2016.01.056","article-title":"Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress","volume":"303","author":"Perrine","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1415","doi-asserted-by":"crossref","first-page":"e0155759","DOI":"10.1371\/journal.pone.0155759","article-title":"Impaired ethanol-induced sensitization and decreased cannabinoid receptor-1 in a model of posttraumatic stress disorder","volume":"11","author":"Matchynski-Franks","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.phrs.2019.02.001_bib1420","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1037\/bne0000151","article-title":"The organization of defensive behavior elicited by optogenetic excitation of rat lateral or ventrolateral periaqueductal gray","volume":"130","author":"Assareh","year":"2016","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1425","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2004.01.026","article-title":"Organization of single components of defensive behaviors within distinct columns of periaqueductal gray matter of the rat: role of N-methyl-d-aspartic acid glutamate receptors","volume":"125","author":"Bittencourt","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2019.02.001_bib1430","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0165-1781(95)02673-K","article-title":"Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: elements of face and predictive validity","volume":"57","author":"Jenck","year":"1995","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1435","doi-asserted-by":"crossref","first-page":"e00579","DOI":"10.1002\/brb3.579","article-title":"fMRI functional connectivity of the periaqueductal gray in PTSD and its dissociative subtype","volume":"6","author":"Harricharan","year":"2016","journal-title":"Brain Behav."},{"key":"10.1016\/j.phrs.2019.02.001_bib1440","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/hbm.23340","article-title":"Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder","volume":"38","author":"Thome","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.phrs.2019.02.001_bib1445","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1002\/hbm.23748","article-title":"Dynamic causal modeling in PTSD and its dissociative subtype: bottom-up versus top-down processing within fear and emotion regulation circuitry","volume":"38","author":"Nicholson","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.phrs.2019.02.001_bib1450","doi-asserted-by":"crossref","first-page":"14795","DOI":"10.1073\/pnas.1310845110","article-title":"Dorsal periaqueductal gray-amygdala pathway conveys both innate and learned fear responses in rats","volume":"110","author":"Kim","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.02.001_bib1455","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1037\/0735-7044.107.6.1093","article-title":"Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and long-term contextual fear","volume":"107","author":"Kim","year":"1993","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2009\/904568","article-title":"Viral vector induction of CREB expression in the periaqueductal gray induces a predator stress-like pattern of changes in pCREB expression, neuroplasticity, and anxiety in rodents","volume":"2009","author":"Adamec","year":"2009","journal-title":"Neural Plast."},{"key":"10.1016\/j.phrs.2019.02.001_bib1465","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s004060200014","article-title":"Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study","volume":"252","author":"Pissiota","year":"2002","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1470","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neubiorev.2016.10.012","article-title":"The periaqueductal gray and primal emotional processing critical to influence complex defensive responses, fear learning and reward seeking","volume":"76","author":"Motta","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phrs.2019.02.001_bib1475","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pbb.2013.12.001","article-title":"Connecting the pathology of posttraumatic stress and substance use disorders: monoamines and neuropeptides","volume":"117","author":"Enman","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2019.02.001_bib1480","doi-asserted-by":"crossref","first-page":"e700","DOI":"10.1038\/tp.2015.196","article-title":"Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder","volume":"5","author":"Morey","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1485","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.expneurol.2007.08.007","article-title":"Conditioned place aversion organized in the dorsal periaqueductal gray recruits the laterodorsal nucleus of the thalamus and the basolateral amygdala","volume":"208","author":"Zanoveli","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1490","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.1144298","article-title":"When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans","volume":"317","author":"Mobbs","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.phrs.2019.02.001_bib1495","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0006-3223(93)90096-V","article-title":"Hypersensitivity of the hypothalamic\u2013pituitary\u2013adrenal axis to naloxone in post-traumatic stress disorder","volume":"33","author":"Hockings","year":"1993","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1500","doi-asserted-by":"crossref","first-page":"e50361","DOI":"10.1371\/journal.pone.0050361","article-title":"The dorsolateral periaqueductal gray and its role in mediating fear learning to life threatening events","volume":"7","author":"Kincheski","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2019.02.001_bib1505","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.tins.2006.08.002","article-title":"Arousal and reward: a dichotomy in orexin function","volume":"29","author":"Harris","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1510","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.psyneuen.2014.07.026","article-title":"Effects of dorsal periaqueductal gray CRF1- and CRF2-receptor stimulation in animal models of panic","volume":"49","author":"de Oliveira Sergio","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1515","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fnana.2014.00136","article-title":"The hypothalamus and periaqueductal gray are the sources of dopamine fibers in the paraventricular nucleus of the thalamus in the rat","volume":"8","author":"Li","year":"2014","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.phrs.2019.02.001_bib1520","first-page":"4138","article-title":"Cerebrospinal fluid corticotropin-releasing hormone in healthy humans: effects of yohimbine and naloxone","volume":"85","author":"Vythilingam","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2019.02.001_bib1525","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/hup.395","article-title":"Short-term treatment of post-traumatic stress disorder with naltrexone: an open-label preliminary study","volume":"17","author":"Lubin","year":"2002","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"10.1016\/j.phrs.2019.02.001_bib1530","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neuroscience.2011.11.057","article-title":"Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it","volume":"204","author":"Riebe","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2019.02.001_bib1535","doi-asserted-by":"crossref","first-page":"625469","DOI":"10.1155\/2009\/625469","article-title":"Antiaversive effects of cannabinoids: is the periaqueductal gray involved?","volume":"2009","author":"Moreira","year":"2009","journal-title":"Neural Plast."},{"key":"10.1016\/j.phrs.2019.02.001_bib1540","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2009\/462879","article-title":"The role of the periaqueductal gray in the modulation of pain in males and females: are the anatomy and physiology really that different?","volume":"2009","author":"Loyd","year":"2009","journal-title":"Neural Plast."},{"key":"10.1016\/j.phrs.2019.02.001_bib1545","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/j.1460-9568.2008.06100.x","article-title":"Sexually dimorphic activation of the periaqueductal gray-rostral ventromedial medullary circuit during the development of tolerance to morphine in the rat","volume":"27","author":"Loyd","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1550","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1056\/NEJMoa0903326","article-title":"Morphine use after combat injury in Iraq and post-traumatic stress disorder","volume":"362","author":"Holbrook","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2019.02.001_bib1555","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s00213-014-3811-z","article-title":"Effect of morphine on the persistence of long-term memory in rats","volume":"232","author":"Porto","year":"2015","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2019.02.001_bib1560","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00008877-200011000-00005","article-title":"Place aversion induced by blockade of mu or activation of kappa opioid receptors in the dorsal periaqueductal gray matter","volume":"11","author":"Sante","year":"2000","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1565","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tins.2011.03.005","article-title":"Placing prediction into the fear circuit","volume":"34","author":"McNally","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1570","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00213-002-1246-4","article-title":"Role of benzodiazepine and serotonergic mechanisms in conditioned freezing and antinociception using electrical stimulation of the dorsal periaqueductal gray as unconditioned stimulus in rats","volume":"165","author":"Castilho","year":"2002","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2019.02.001_bib1575","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/npp.2010.231","article-title":"Acquisition of Pavlovian fear conditioning using \u03b2-adrenoceptor activation of the dorsal premammillary nucleus as an unconditioned stimulus to mimic live predator-threat exposure","volume":"36","author":"Pavesi","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2019.02.001_bib1580","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bbr.2016.08.021","article-title":"Acquisition and expression of fear memories are distinctly modulated along the dorsolateral periaqueductal gray axis of rats exposed to predator odor","volume":"315","author":"Souza","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1585","doi-asserted-by":"crossref","first-page":"13296","DOI":"10.1523\/JNEUROSCI.2843-08.2008","article-title":"New perspectives on beta-adrenergic mediation of innate and learned fear responses to predator odor","volume":"28","author":"Do Monte","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2019.02.001_bib1590","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1001\/archpsyc.1997.01830150070011","article-title":"Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder","volume":"54","author":"Bremner","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2019.02.001_bib1595","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.euroneuro.2010.05.004","article-title":"Involvement of dorsal raphe nucleus and dorsal periaqueductal gray 5-HT receptors in the modulation of mouse defensive behaviors","volume":"21","author":"Pobbe","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2019.02.001_bib1600","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2012.04.032","article-title":"Buspirone: what is it all about?","volume":"1461","author":"Loane","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2019.02.001_bib1605","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/10401239409148837","article-title":"Efficacy of buspirone in the treatment of posttraumatic stress disorder: an open trial","volume":"6","author":"Duffy","year":"1994","journal-title":"Ann. Clin. Psychiatry"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818311721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818311721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:56:32Z","timestamp":1760910992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818311721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":321,"alternative-id":["S1043661818311721"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2019.02.001","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advances in the neurobiology of posttraumatic stress disorder: A review of possible mechanisms underlying an effective pharmacotherapy","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2019.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}