{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T07:15:59Z","timestamp":1778397359706,"version":"3.51.4"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.phrs.2019.104334","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:21:17Z","timestamp":1561681277000},"page":"104334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Mechanisms explaining the efficacy of psoralidin in cancer and osteoporosis, a review"],"prefix":"10.1016","volume":"147","author":[{"given":"Zhenlong","family":"Xin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2019.104334_bib0005","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.phymed.2011.02.002","article-title":"Estrogenic activities of psoralea corylifolia l. Seed extracts and main constituents","volume":"18","author":"Lim","year":"2011","journal-title":"Phytomedicine."},{"key":"10.1016\/j.phrs.2019.104334_bib0010","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.fitote.2013.06.016","article-title":"Psoralea corylifolia l. (buguchi) - folklore to modern evidence: review","volume":"90","author":"Chopra","year":"2013","journal-title":"Fitoterapia."},{"key":"10.1016\/j.phrs.2019.104334_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1142\/S0192415X16500038","article-title":"The chemical constituents and bioactivities of psoralea corylifolia linn.: a review","volume":"44","author":"Zhang","year":"2016","journal-title":"Am. J. Chin. Med. (Gard City N Y)"},{"key":"10.1016\/j.phrs.2019.104334_bib0020","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1021\/jo8025884","article-title":"Total synthesis of psoralidin, an anticancer natural product","volume":"74","author":"Pahari","year":"2009","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phrs.2019.104334_bib0025","first-page":"2328","article-title":"[Chemical constituents from psoralea corylifolia and their antioxidant alpha-glucosidase inhibitory and antimicrobial activities]","volume":"38","author":"Wang","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.phrs.2019.104334_bib0030","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.fitote.2003.12.018","article-title":"Antibacterial compounds from the seeds of psoralea corylifolia","volume":"75","author":"Khatune","year":"2004","journal-title":"Fitoterapia."},{"key":"10.1016\/j.phrs.2019.104334_bib0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.phytochem.2017.08.004","article-title":"Isoflavones and anti-inflammatory constituents from the fruits of psoralea corylifolia","volume":"143","author":"Chen","year":"2017","journal-title":"Phytochemistry."},{"key":"10.1016\/j.phrs.2019.104334_bib0040","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.pnpbp.2007.10.005","article-title":"Antidepressant-like effects of psoralidin isolated from the seeds of psoralea corylifolia in the forced swimming test in mice","volume":"32","author":"Yi","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2019.104334_bib0045","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.lfs.2008.03.014","article-title":"Transcriptional regulation of corticotrophin releasing factor gene by furocoumarins isolated from seeds of psoralea corylifolia","volume":"82","author":"Chen","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2019.104334_bib0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/bjc.2017.143","article-title":"Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis","volume":"117","author":"Pal","year":"2017","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.phrs.2019.104334_bib0055","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1038\/bjc.2013.642","article-title":"Silencing notch signaling causes growth arrest in both breast cancer stem cells and breast cancer cells","volume":"109","author":"Suman","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.phrs.2019.104334_bib0060","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3892\/ol.2015.3861","article-title":"Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-kappab and b-cell lymphoma-2\/b-cell lymphoma-2-associated x protein signaling pathways","volume":"11","author":"Jin","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.phrs.2019.104334_bib0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2017.07.003","article-title":"Psoralidin suppresses osteoclastogenesis in bmms and attenuates lps-mediated osteolysis by inhibiting inflammatory cytokines","volume":"51","author":"Kong","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2019.104334_bib0070","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3892\/ol.2016.4716","article-title":"Psoralidin inhibits proliferation and enhances apoptosis of human esophageal carcinoma cells via nf-kappab and pi3k\/akt signaling pathways","volume":"12","author":"Jin","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.phrs.2019.104334_bib0075","doi-asserted-by":"crossref","first-page":"e555","DOI":"10.7717\/peerj.555","article-title":"Psoralidin induces autophagy through ros generation which inhibits the proliferation of human lung cancer a549 cells","volume":"2","author":"Hao","year":"2014","journal-title":"PeerJ."},{"key":"10.1016\/j.phrs.2019.104334_bib0080","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.biopha.2018.03.166","article-title":"The higher osteoprotective activity of psoralidin in vivo than coumestrol is attributed by its presence of an isopentenyl group and through activated pi3k\/akt axis","volume":"102","author":"Zhai","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phrs.2019.104334_bib0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2174\/187153012803832602","article-title":"Oxidative stress in atherosclerosis development: the central role of ldl and oxidative burst","volume":"12","author":"Peluso","year":"2012","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.phrs.2019.104334_bib0090","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1161\/CIRCULATIONAHA.117.031385","article-title":"Regarding article, \"particulate matter exposure and stress hormone levels: a randomized, double-blind, crossover trial of air purification\"","volume":"137","author":"Li","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2019.104334_bib0095","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/pros.20137","article-title":"Increased nox1 and hydrogen peroxide in prostate cancer","volume":"62","author":"Lim","year":"2005","journal-title":"Prostate"},{"key":"10.1016\/j.phrs.2019.104334_bib0100","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1172\/JCI76725","article-title":"Zeb1 drives epithelial-to-mesenchymal transition in lung cancer","volume":"126","author":"Larsen","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2019.104334_bib0105","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ros-mediated mechanisms: A radical therapeutic approach?","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phrs.2019.104334_bib0110","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mc.22014","article-title":"Induction of reactive oxygen species generation inhibits epithelial-mesenchymal transition and promotes growth arrest in prostate cancer cells","volume":"53","author":"Das","year":"2014","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.phrs.2019.104334_bib0115","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1089\/ars.2013.5603","article-title":"Nadph oxidases: a perspective on reactive oxygen species production in tumor biology","volume":"20","author":"Meitzler","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phrs.2019.104334_bib0120","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3109\/1061186X.2015.1036276","article-title":"The human nox4: gene, structure, physiological function and pathological significance","volume":"23","author":"Guo","year":"2015","journal-title":"J. Drug Target."},{"key":"10.1016\/j.phrs.2019.104334_bib0125","first-page":"1229","article-title":"Programmed cell death - strategy for maintenance cellular organisms homeostasis","volume":"70","author":"Godlewski","year":"2016","journal-title":"Postepy Hig Med Dosw (Online)."},{"key":"10.1016\/j.phrs.2019.104334_bib0130","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1242\/jcs.040188","article-title":"The vdac1 n-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins","volume":"122","author":"Abu-Hamad","year":"2009","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.phrs.2019.104334_bib0135","first-page":"573","article-title":"Why target apoptosis in cancer treatment?","volume":"2","author":"Kasibhatla","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.phrs.2019.104334_bib0140","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.7150\/thno.25674","article-title":"Ampk: potential therapeutic target for ischemic stroke","volume":"8","author":"Jiang","year":"2018","journal-title":"Theranostics."},{"key":"10.1016\/j.phrs.2019.104334_bib0145","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","author":"Al-Hajj","year":"2003","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.phrs.2019.104334_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2014.03.036","article-title":"Breast cancer stem cells: multiple capacities in tumor metastasis","volume":"349","author":"Geng","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2019.104334_bib0155","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical notch signaling pathway: unfolding the activation mechanism","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell."},{"key":"10.1016\/j.phrs.2019.104334_bib0160","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of notch1 in human t cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.phrs.2019.104334_bib0165","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1535-6108(03)00140-5","article-title":"Notch mediates tgf alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis","volume":"3","author":"Miyamoto","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phrs.2019.104334_bib0170","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1038\/onc.2008.226","article-title":"Rational targeting of notch signaling in cancer","volume":"27","author":"Rizzo","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.phrs.2019.104334_bib0175","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1158\/0008-5472.CAN-07-1022","article-title":"Gamma-secretase inhibitor prevents notch3 activation and reduces proliferation in human lung cancers","volume":"67","author":"Konishi","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2019.104334_bib0180","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/mc.22579","article-title":"Targeting aberrant expression of notch-1 in aldh(+) cancer stem cells in breast cancer","volume":"56","author":"Pal","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.phrs.2019.104334_bib0185","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1359-6101(03)00029-7","article-title":"Apo2l\/trail: apoptosis signaling, biology, and potential for cancer therapy","volume":"14","author":"Almasan","year":"2003","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.phrs.2019.104334_bib0190","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.2741\/1903","article-title":"Apo2 ligand\/tumor necrosis factor-related apoptosis-inducing ligand in prostate cancer therapy","volume":"11","author":"Bucur","year":"2006","journal-title":"Front Biosci."},{"key":"10.1016\/j.phrs.2019.104334_bib0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1734-1140(11)70408-X","article-title":"Enhanced trail-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from psoralea corylifolia","volume":"63","author":"Szliszka","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.phrs.2019.104334_bib0200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.drup.2008.02.001","article-title":"Trail receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them","volume":"11","author":"Thorburn","year":"2008","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.phrs.2019.104334_bib0205","doi-asserted-by":"crossref","first-page":"9238","DOI":"10.1073\/pnas.91.20.9238","article-title":"Interactions among members of the bcl-2 protein family analyzed with a yeast two-hybrid system","volume":"91","author":"Sato","year":"1994","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.phrs.2019.104334_bib0210","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.arr.2017.11.002","article-title":"Foxo1\/3: potential suppressors of fibrosis","volume":"41","author":"Xin","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phrs.2019.104334_bib0215","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3748\/wjg.v11.i5.721","article-title":"Correlation between expression of gastrin, somatostatin and cell apoptosis regulation gene bcl-2\/bax in large intestine carcinoma","volume":"11","author":"Mao","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2019.104334_bib0220","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1388-1981(02)00300-1","article-title":"The nuclear phosphoinositide 3-kinase\/akt pathway: a new second messenger system","volume":"1584","author":"Neri","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2019.104334_bib0225","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/07853890.2014.912836","article-title":"Pi3k\/akt signaling pathway and cancer: an updated review","volume":"46","author":"Martini","year":"2014","journal-title":"Ann. Med."},{"key":"10.1016\/j.phrs.2019.104334_bib0230","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2119\/2006-00072.Miskolci","article-title":"Nfkappab is persistently activated in continuously stimulated human neutrophils","volume":"13","author":"Miskolci","year":"2007","journal-title":"Mol Med."},{"key":"10.1016\/j.phrs.2019.104334_bib0235","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3892\/etm.2013.1196","article-title":"Andrographolide inhibits the activation of nf-kappab and mmp-9 activity in h3255 lung cancer cells","volume":"6","author":"Luo","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phrs.2019.104334_bib0240","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1189\/jlb.0106024","article-title":"Molecular basis of age-associated cytokine dysregulation in lps-stimulated macrophages","volume":"79","author":"Chelvarajan","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.phrs.2019.104334_bib0245","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/molehr\/gal023","article-title":"Involvement of mapk pathway in tnf-alpha-induced mmp-9 expression in human trophoblastic cells","volume":"12","author":"Cohen","year":"2006","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.phrs.2019.104334_bib0250","first-page":"2251","article-title":"The molecular pathway of psoralidin-induced apoptosis in hepg2 cell line","author":"Yu","year":"2016","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phrs.2019.104334_bib0255","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.arr.2018.08.002","article-title":"Amp-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing","volume":"47","author":"Gu","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phrs.2019.104334_bib0260","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrclinonc.2011.71","article-title":"Autophagy as a target for anticancer therapy","volume":"8","author":"Janku","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phrs.2019.104334_bib0265","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.biocel.2004.05.009","article-title":"Lc3 conjugation system in mammalian autophagy","volume":"36","author":"Tanida","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.phrs.2019.104334_bib0270","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1091\/mbc.E15-09-0618","article-title":"Developing a set of guidelines for your research field: a practical approach","volume":"27","author":"Klionsky","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.phrs.2019.104334_bib0275","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2217\/WHE.13.73","article-title":"A review of osteoporosis management in younger premenopausal women","volume":"10","author":"McLendon","year":"2014","journal-title":"Womens Health Lond. (Lond)"},{"key":"10.1016\/j.phrs.2019.104334_bib0280","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.bmcl.2014.01.029","article-title":"Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from psoralea corylifolia","volume":"24","author":"Liu","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phrs.2019.104334_bib0285","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejphar.2017.03.001","article-title":"Psoralidin, a prenylated coumestan, as a novel anti-osteoporosis candidate to enhance bone formation of osteoblasts and decrease bone resorption of osteoclasts","volume":"801","author":"Zhai","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2019.104334_bib0290","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1002\/jbmr.2882","article-title":"Anti-osteoporosis medication prescriptions and incidence of subsequent fracture among primary hip fracture patients in england and wales: an interrupted time-series analysis","volume":"31","author":"Hawley","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phrs.2019.104334_bib0295","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1007\/s00198-016-3631-6","article-title":"The current economic burden of illness of osteoporosis in canada","volume":"27","author":"Hopkins","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.phrs.2019.104334_bib0300","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.arr.2017.07.001","article-title":"Ampk orchestrates an elaborate cascade protecting tissue from fibrosis and aging","volume":"38","author":"Jiang","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phrs.2019.104334_bib0305","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10875-009-9316-6","article-title":"Osteoimmunology: crosstalk between the immune and bone systems","volume":"29","author":"Nakashima","year":"2009","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.phrs.2019.104334_bib0310","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.phrs.2019.104334_bib0315","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2019.104334_bib0320","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bone.2007.05.016","article-title":"Interleukin-10 inhibits rankl-mediated expression of nfatc1 in part via suppression of c-fos and c-jun in raw264.7 cells and mouse bone marrow cells","volume":"41","author":"Mohamed","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.phrs.2019.104334_bib0325","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.190.12.1741","article-title":"Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-fms and receptor activator of nuclear factor kappab (rank) receptors","volume":"190","author":"Arai","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2019.104334_bib0330","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/edrv.20.3.0367","article-title":"Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families","volume":"20","author":"Suda","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phrs.2019.104334_bib0335","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/molecules21081076","article-title":"Quantitative analysis of psoralea corylifolia linne and its neuroprotective and anti-neuroinflammatory effects in ht22 hippocampal cells and bv-2 microglia","volume":"21","author":"Kim","year":"2016","journal-title":"Molecules."},{"key":"10.1016\/j.phrs.2019.104334_bib0340","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phymed.2009.05.015","article-title":"Phytoestrogens from psoralea corylifolia reveal estrogen receptor-subtype selectivity","volume":"17","author":"Xin","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2019.104334_bib0345","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s10495-016-1225-6","article-title":"Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1","volume":"21","author":"Feng","year":"2016","journal-title":"Apoptosis"},{"key":"10.1016\/j.phrs.2019.104334_bib0350","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/897296","article-title":"Psoralea corylifolia l. Seed extract ameliorates streptozotocin-induced diabetes in mice by inhibition of oxidative stress","volume":"2014","author":"Seo","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phrs.2019.104334_bib0355","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.taap.2013.03.017","article-title":"Protective effects of the compounds isolated from the seed of psoralea corylifolia on oxidative stress-induced retinal damage","volume":"269","author":"Kim","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2019.104334_bib0360","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1021\/np970488q","article-title":"DNA polymerase and topoisomerase ii inhibitors from psoralea corylifolia","volume":"61","author":"Sun","year":"1998","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phrs.2019.104334_bib0365","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1089\/jmf.2009.1207","article-title":"Isolation and anti-inflammatory activity of bakuchiol from ulmus davidiana var","volume":"13","author":"Choi","year":"2010","journal-title":"Japonica, J Med Food."},{"key":"10.1016\/j.phrs.2019.104334_bib0370","doi-asserted-by":"crossref","first-page":"8977","DOI":"10.3892\/mmr.2017.7696","article-title":"Antitumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through pi3k\/akt and mapk signaling pathways","volume":"16","author":"Lv","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phrs.2019.104334_bib0375","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1017\/S0007114508066750","article-title":"Ethanol extract of psoralea corylifolia l. And its main constituent, bakuchiol, reduce bone loss in ovariectomised sprague-dawley rats","volume":"101","author":"Lim","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phrs.2019.104334_bib0380","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.arr.2019.04.001","article-title":"Lncrna: shedding light on mechanisms and opportunities in fibrosis and aging","volume":"52","author":"Yang","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phrs.2019.104334_bib0385","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cell.2014.03.008","article-title":"The noncoding rna revolution-trashing old rules to forge new ones","volume":"157","author":"Cech","year":"2014","journal-title":"Cell."},{"key":"10.1016\/j.phrs.2019.104334_bib0390","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ccell.2016.03.010","article-title":"Long noncoding rnas in cancer pathways","volume":"29","author":"Schmitt","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phrs.2019.104334_bib0395","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2016.06.011","article-title":"Nuclear noncoding rnas and genome stability","volume":"63","author":"Khanduja","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phrs.2019.104334_bib0400","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cancergen.2017.06.003","article-title":"Regulatory mechanisms of long noncoding rnas on gene expression in cancers","volume":"216-217","author":"Sun","year":"2017","journal-title":"Cancer Genet."},{"key":"10.1016\/j.phrs.2019.104334_bib0405","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12943-016-0530-6","article-title":"Long noncoding rnas in cancer: mechanisms of action and technological advancements","volume":"15","author":"Bartonicek","year":"2016","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phrs.2019.104334_bib0410","doi-asserted-by":"crossref","first-page":"e2638","DOI":"10.1038\/cddis.2017.66","article-title":"2-o-methylmagnolol upregulates the long non-coding rna, gas5, and enhances apoptosis in skin cancer cells","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phrs.2019.104334_bib0415","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1158\/1541-7786.MCR-13-0636","article-title":"Involvement of extracellular vesicle long noncoding rna (linc-vldlr) in tumor cell responses to chemotherapy","volume":"12","author":"Takahashi","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.phrs.2019.104334_bib0420","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3390\/ijms19020380","article-title":"Corylin suppresses hepatocellular carcinoma progression via the inhibition of epithelial-mesenchymal transition, mediated by long noncoding rna gas5","volume":"19","author":"Chen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2019.104334_bib0425","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.biocel.2017.11.009","article-title":"Baicalein inhibits cervical cancer progression via downregulating long noncoding rna bdlnr and its downstream pi3k\/akt pathway","volume":"94","author":"Yu","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.phrs.2019.104334_bib0430","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.intimp.2015.07.012","article-title":"Baicalein attenuates inflammatory responses by suppressing tlr4 mediated nf-kappab and mapk signaling pathways in lps-induced mastitis in mice","volume":"28","author":"He","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2019.104334_bib0435","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1002\/jcp.24900","article-title":"Baicalein decreases hydrogen peroxide-induced damage to ng108-15 cells via upregulation of nrf2","volume":"230","author":"Yeh","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phrs.2019.104334_bib0440","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1158\/1078-0432.CCR-04-1974","article-title":"Characterization of chemical constituents in scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma","volume":"11","author":"Bonham","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2019.104334_bib0445","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.canlet.2014.12.033","article-title":"Baicalein upregulates ddit4 expression which mediates mtor inhibition and growth inhibition in cancer cells","volume":"358","author":"Wang","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2019.104334_bib0450","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/fcp.12036","article-title":"Mitigating role of baicalein on lysosomal enzymes and xenobiotic metabolizing enzyme status during lung carcinogenesis of swiss albino mice induced by benzo(a)pyrene","volume":"28","author":"Naveenkumar","year":"2014","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.phrs.2019.104334_bib0455","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1177\/1758834017742576","article-title":"Foxc1 in cancer development and therapy: deciphering its emerging and divergent roles","volume":"9","author":"Yang","year":"2017","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.phrs.2019.104334_bib0460","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/ijc.31338","article-title":"Deciphering the roles of foxo1 in human neoplasms","author":"Jiang","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.phrs.2019.104334_bib0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2018.04.007","article-title":"Novel role of forkhead box o 4 transcription factor in cancer: bringing out the good or the bad","volume":"50","author":"Jiang","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phrs.2019.104334_bib0470","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jamaoncol.2018.1209","article-title":"Database selection and heterogeneity-more details, more credibility","volume":"4","author":"Li","year":"2018","journal-title":"JAMA Oncol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661819302816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661819302816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:59:29Z","timestamp":1760911169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661819302816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":94,"alternative-id":["S1043661819302816"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2019.104334","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms explaining the efficacy of psoralidin in cancer and osteoporosis, a review","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2019.104334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104334"}}