{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:22:19Z","timestamp":1789791739961,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371250"],"award-info":[{"award-number":["81371250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873732"],"award-info":[{"award-number":["81873732"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571053"],"award-info":[{"award-number":["81571053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771196"],"award-info":[{"award-number":["81771196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.phrs.2019.104339","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T14:42:37Z","timestamp":1562078557000},"page":"104339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Pharmacological inhibition of the NLRP3 in\ufb02ammasome as a potential target for cancer-induced bone pain"],"prefix":"10.1016","volume":"147","author":[{"given":"Shu-Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Qun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem","family":"HaiSam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Wei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ke","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2019.104339_bib0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.phrs.2018.07.002","article-title":"Minocycline as a promising therapeutic strategy for chronic pain","volume":"134","author":"Zhou","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.phrs.2019.104339_bib0010","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1124\/jpet.117.243048","article-title":"Cellular and molecular mechanisms of calcium\/calmodulin-dependent protein kinase II in chronic pain","volume":"363","author":"Zhou","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"11","key":"10.1016\/j.phrs.2019.104339_bib0015","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1080\/14728222.2016.1214716","article-title":"Targeting glia for bone cancer pain","volume":"20","author":"Zhou","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"issue":"12","key":"10.1016\/j.phrs.2019.104339_bib0020","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.2174\/1381612823666170210150147","article-title":"PI3K\/Akt pathway: a potential therapeutic target for chronic pain","volume":"23","author":"Chen","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.phrs.2019.104339_bib0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.expneurol.2014.09.019","article-title":"Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats","volume":"263","author":"Guan","year":"2015","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2019.104339_bib0030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/art.24185","article-title":"Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout","volume":"60","author":"Martin","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.phrs.2019.104339_bib0035","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.freeradbiomed.2014.04.021","article-title":"TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout","volume":"72","author":"Trevisan","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2019.104339_bib0040","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.phymed.2018.04.045","article-title":"Role of curcumin in the management of pathological pain","volume":"48","author":"Sun","year":"2018","journal-title":"Phytomed.: Int. J. Phytother. Phytopharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2019.104339_bib0045","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/01.j.pain.0000460322.72396.53","article-title":"Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain","volume":"156","author":"Lopes","year":"2015","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.phrs.2019.104339_bib0050","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12974-017-0849-y","article-title":"Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression","volume":"14","author":"Liu","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.phrs.2019.104339_bib0055","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12974-017-0971-x","article-title":"Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain","volume":"14","author":"Doyen","year":"2017","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.phrs.2019.104339_bib0060","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12974-018-1133-5","article-title":"Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury","volume":"15","author":"Kiguchi","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2019.104339_bib0065","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1038\/cddis.2012.86","article-title":"Caspase-1: is IL-1 just the tip of the ICEberg?","volume":"3","author":"Denes","year":"2012","journal-title":"Cell Death Dis."},{"issue":"5053","key":"10.1016\/j.phrs.2019.104339_bib0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1373520","article-title":"Molecular cloning of the interleukin-1 beta converting enzyme","volume":"256","author":"Cerretti","year":"1992","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phrs.2019.104339_bib0075","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.immuni.2015.06.003","article-title":"Proteolytic processing of Interleukin-1 family cytokines: variations on a common theme","volume":"42","author":"Afonina","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.phrs.2019.104339_bib0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbi.2015.06.016","article-title":"Early single Aspirin-triggered Lipoxin blocked morphine anti-nociception tolerance through inhibiting NALP1 inflammasome: involvement of PI3k\/Akt signaling pathway","volume":"50","author":"Tian","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.phrs.2019.104339_bib0085","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.phrs.2019.104339_bib0090","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/bja\/aew376","article-title":"The inflammasome as a target for pain therapy","volume":"117","author":"Zhang","year":"2016","journal-title":"Br. J. Anaesth."},{"issue":"10","key":"10.1016\/j.phrs.2019.104339_bib0095","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41583-018-0055-7","article-title":"Inflammasome signalling in brain function and neurodegenerative disease","volume":"19","author":"Heneka","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"issue":"Pt 5","key":"10.1016\/j.phrs.2019.104339_bib0100","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1242\/jcs.113.5.753","article-title":"Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies","volume":"113","author":"Wang","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phrs.2019.104339_bib0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2018.01.034","article-title":"The NLRP3 inflammasome: role in metabolic disorders and regulation by metabolic pathways","volume":"419","author":"Jiang","year":"2018","journal-title":"Cancer Lett."},{"issue":"7081","key":"10.1016\/j.phrs.2019.104339_bib0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.phrs.2019.104339_bib0115","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration","volume":"14","author":"Petrilli","year":"2007","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.phrs.2019.104339_bib0120","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2019.104339_bib0125","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2019.104339_bib0130","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.intimp.2015.05.008","article-title":"Fluorofenidone inhibits macrophage IL-1beta production by suppressing inflammasome activity","volume":"27","author":"Lu","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2019.104339_bib0135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbi.2017.08.004","article-title":"Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain","volume":"67","author":"Gao","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2019.104339_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2017.10.016","article-title":"Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice","volume":"300","author":"Tonkin","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2019.104339_bib0145","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2147\/JPR.S119820","article-title":"Bay11-7082 attenuates neuropathic pain via inhibition of nuclear factor-kappa B and nucleotide-binding domain-like receptor protein 3 inflammasome activation in dorsal root ganglions in a rat model of lumbar disc herniation","volume":"10","author":"Zhang","year":"2017","journal-title":"J. Pain Res."},{"issue":"3","key":"10.1016\/j.phrs.2019.104339_bib0150","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.phrs.2019.104339_bib0155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-3565(24)29317-4","article-title":"Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors","volume":"299","author":"Perregaux","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.phrs.2019.104339_bib0160","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s10753-016-0483-3","article-title":"Inhibition of NLRP3 inflammasome prevents LPS-induced inflammatory hyperalgesia in mice: contribution of NF-kappaB, caspase-1\/11, ASC, NOX, and NOS isoforms","volume":"40","author":"Dolunay","year":"2017","journal-title":"Inflammation"},{"issue":"8","key":"10.1016\/j.phrs.2019.104339_bib0165","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1161\/ATVBAHA.117.309575","article-title":"NLRP3 inflammasome inhibition by MCC950 reduces atherosclerotic lesion development in apolipoprotein E-deficient mice-brief report","volume":"37","author":"van der Heijden","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.phrs.2019.104339_bib0170","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918793232","article-title":"Sinomenine attenuates cancer-induced bone pain via suppressing microglial JAK2\/STAT3 and neuronal CAMKII\/CREB cascades in rat models","volume":"14","author":"Chen","year":"2018","journal-title":"Mol. Pain"},{"issue":"8","key":"10.1016\/j.phrs.2019.104339_bib0175","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jpain.2017.02.438","article-title":"The role of spinal GABAB receptors in cancer-induced bone pain in rats","volume":"18","author":"Zhou","year":"2017","journal-title":"J. Pain"},{"key":"10.1016\/j.phrs.2019.104339_bib0180","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.redox.2017.10.011","article-title":"Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain","volume":"14","author":"Zhou","year":"2018","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.phrs.2019.104339_bib0185","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/aps.2016.1","article-title":"Minocycline attenuates bone cancer pain in rats by inhibiting NF-kappaB in spinal astrocytes","volume":"37","author":"Song","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.phrs.2019.104339_bib0190","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/FBP.0b013e32833e7e2a","article-title":"Intrathecal injection of anti-CX3CR1 neutralizing antibody delayed and attenuated pain facilitation in rat tibial bone cancer pain model","volume":"21","author":"Yin","year":"2010","journal-title":"Behav. Pharmacol."},{"issue":"6","key":"10.1016\/j.phrs.2019.104339_bib0195","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/jnr.22815","article-title":"Brain-derived neurotrophic factor modulates N-methyl-D-aspartate receptor activation in a rat model of cancer-induced bone pain","volume":"90","author":"Wang","year":"2012","journal-title":"J. Neurosci. Res."},{"issue":"Pt 1","key":"10.1016\/j.phrs.2019.104339_bib0200","first-page":"1","article-title":"The role of spinal interleukin-1beta and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model","volume":"287","author":"Choi","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2019.104339_bib0205","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2019.104339_bib0210","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"issue":"20","key":"10.1016\/j.phrs.2019.104339_bib0215","doi-asserted-by":"crossref","first-page":"7950","DOI":"10.1523\/JNEUROSCI.5250-14.2015","article-title":"Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18","volume":"35","author":"Yang","year":"2015","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2019.104339_bib0220","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/jnc.13139","article-title":"Activation of PI3Kgamma\/Akt pathway mediates bone cancer pain in rats","volume":"134","author":"Guan","year":"2015","journal-title":"J. Neurochem."},{"issue":"9","key":"10.1016\/j.phrs.2019.104339_bib0225","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.celrep.2017.02.004","article-title":"Beta-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares","volume":"18","author":"Goldberg","year":"2017","journal-title":"Cell Rep."},{"issue":"24","key":"10.1016\/j.phrs.2019.104339_bib0230","doi-asserted-by":"crossref","first-page":"E3441","DOI":"10.1073\/pnas.1602070113","article-title":"Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation","volume":"113","author":"Grace","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.phrs.2019.104339_bib0235","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1523\/JNEUROSCI.2235-16.2016","article-title":"TNF-alpha differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury","volume":"37","author":"Liu","year":"2017","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2019.104339_bib0240","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nri1997","article-title":"Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation","volume":"7","author":"Mariathasan","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2019.104339_bib0245","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.coi.2007.09.002","article-title":"The inflammasome: a danger sensing complex triggering innate immunity","volume":"19","author":"Petrilli","year":"2007","journal-title":"Curr. Opin. Immunol."},{"issue":"7381","key":"10.1016\/j.phrs.2019.104339_bib0250","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phrs.2019.104339_bib0255","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nrn3638","article-title":"Inflammasomes in the CNS","volume":"15","author":"Walsh","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"issue":"5","key":"10.1016\/j.phrs.2019.104339_bib0260","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1369\/jhc.6A7101.2006","article-title":"Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response","volume":"55","author":"Kummer","year":"2007","journal-title":"J. Histochem. Cytochem."},{"issue":"2","key":"10.1016\/j.phrs.2019.104339_bib0265","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1365-2567.2009.03174.x","article-title":"Expression and function of the NALP3 inflammasome in rheumatoid synovium","volume":"129","author":"Kolly","year":"2010","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.phrs.2019.104339_bib0270","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12974-018-1073-0","article-title":"miRNA-23a\/CXCR4 regulates neuropathic pain via directly targeting TXNIP\/NLRP3 inflammasome axis","volume":"15","author":"Pan","year":"2018","journal-title":"J. Neuroinflammation"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661819303482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661819303482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:31:50Z","timestamp":1778581910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661819303482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":54,"alternative-id":["S1043661819303482"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2019.104339","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological inhibition of the NLRP3 in\ufb02ammasome as a potential target for cancer-induced bone pain","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2019.104339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104339"}}