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Med."},{"key":"10.1016\/j.phrs.2019.104367_bib0550","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/19490976.2016.1145374","article-title":"Chemical conversations in the gut microbiota","volume":"7","author":"Thompson","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2019.104367_bib0555","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/lam.12748","article-title":"Prospective bacterial quorum sensing inhibitors from indian medicinal plant extracts","volume":"65","author":"Tiwary","year":"2017","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.phrs.2019.104367_bib0560","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.3748\/wjg.v10.i12.1802","article-title":"Intestinal microecology and quality of life in irritable bowel syndrome patients","volume":"10","author":"Si","year":"2004","journal-title":"World J. 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Res."},{"key":"10.1016\/j.phrs.2019.104367_bib0640","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11130-018-0689-7","article-title":"Beneficial effect of virgin coconut oil on alloxan-induced diabetes and microbiota composition in rats","volume":"73","author":"Djurasevic","year":"2018","journal-title":"Plant Food Hum. Res."},{"key":"10.1016\/j.phrs.2019.104367_bib0645","doi-asserted-by":"crossref","first-page":"G401","DOI":"10.1152\/ajpgi.00110.2011","article-title":"The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer?","volume":"301","author":"Azc\u00e1rate-Peril","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. 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Int."},{"key":"10.1016\/j.phrs.2019.104367_bib0655","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1099\/mic.0.082610-0","article-title":"Streptozotocin-induced type-1-diabetes disease onset in sprague-dawley rats is associated with an altered intestinal microbiota composition and decreased diversity","volume":"161","author":"Patterson","year":"2015","journal-title":"Microbiology"},{"key":"10.1016\/j.phrs.2019.104367_bib0660","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2174\/138945008784533561","article-title":"The \"classical\" ovalbumin challenge model of asthma in mice","volume":"9","author":"Kumar","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.phrs.2019.104367_bib0665","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaci.2014.11.011","article-title":"The microbiome in asthma","volume":"135","author":"Huang","year":"2015","journal-title":"J. Allergy Clin. 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Soc."},{"key":"10.1016\/j.phrs.2019.104367_bib0675","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/imm.12376","article-title":"Chronic obstructive pulmonary disease and asthma-associated proteobacteria, but not commensal prevotella spp., promote toll-like receptor 2-independent lung inflammation and pathology","volume":"144","author":"Larsen","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.phrs.2019.104367_bib0680","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/19490976.2016.1182293","article-title":"A humanized microbiota mouse model of ovalbumin-induced lung inflammation","volume":"7","author":"Arrieta","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2019.104367_bib0685","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0504s56","article-title":"Models of inflammation: Carrageenan- or complete freund\u2019s adjuvant (cfa)-induced edema and hypersensitivity in the rat","author":"Fehrenbacher","year":"2012","journal-title":"Curr. 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Lett."},{"key":"10.1016\/j.phrs.2019.104367_bib0700","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/AEM.04050-14","article-title":"Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer","volume":"81","author":"Reunanen","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.phrs.2019.104367_bib0705","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3945\/jn.116.240481","article-title":"Microbiota-gut-brain axis: modulator of host metabolism and appetite","volume":"147","author":"van de Wouw","year":"2017","journal-title":"J. Nutr."},{"key":"10.1016\/j.phrs.2019.104367_bib0710","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1046\/j.1365-2362.1998.00393.x","article-title":"Scopolamine model of dementia: electroencephalogram findings and cognitive performance","volume":"28","author":"Ebert","year":"1998","journal-title":"Eur. J. Clin. 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