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Immunol."},{"issue":"5","key":"10.1016\/j.phrs.2019.104408_bib0370","first-page":"291","article-title":"Protective autoantibodies in the rheumatic diseases: lessons for therapy, Nature reviews","volume":"9","author":"Silverman","year":"2013","journal-title":"Rheumatology"},{"issue":"2","key":"10.1016\/j.phrs.2019.104408_bib0375","first-page":"1346","article-title":"Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis","volume":"183","author":"Chen","year":"2009","journal-title":"J. Immunol. 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Autoimmun."},{"issue":"9","key":"10.1016\/j.phrs.2019.104408_bib0460","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.autrev.2011.11.018","article-title":"Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells","volume":"11","author":"Kessel","year":"2012","journal-title":"Autoimmun. 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Immunol."},{"issue":"5","key":"10.1016\/j.phrs.2019.104408_bib0480","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/acel.12114","article-title":"An age-related numerical and functional deficit in CD19(+) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity","volume":"12","author":"Duggal","year":"2013","journal-title":"Aging Cell"},{"issue":"3","key":"10.1016\/j.phrs.2019.104408_bib0485","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.immuni.2016.02.012","article-title":"A regulatory feedback between plasmacytoid dendritic cells and regulatory B cells is aberrant in systemic lupus erythematosus","volume":"44","author":"Menon","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.phrs.2019.104408_bib0490","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.3389\/fimmu.2018.02241","article-title":"PD-L1(+) regulatory B cells are significantly decreased in rheumatoid arthritis patients and increase after successful treatment","volume":"9","author":"Zacca","year":"2018","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.phrs.2019.104408_bib0495","doi-asserted-by":"crossref","first-page":"R118","DOI":"10.1186\/ar4571","article-title":"B cell subsets and dysfunction of regulatory B cells in IgG4-related diseases and primary Sjogren\u2019s syndrome: the similarities and differences","volume":"16","author":"Lin","year":"2014","journal-title":"Arthritis Res. Ther."},{"issue":"21","key":"10.1016\/j.phrs.2019.104408_bib0500","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V120.21.4843.4843","article-title":"Peripheral regulatory B cell phenotype in multiple sclerosis patients","volume":"120","author":"Habib","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.phrs.2019.104408_bib0505","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clim.2017.04.014","article-title":"Effector and regulatory B cells in multiple sclerosis","volume":"184","author":"Staun-Ram","year":"2017","journal-title":"Clin. Immunol."},{"issue":"8","key":"10.1016\/j.phrs.2019.104408_bib0510","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jnr.23749","article-title":"Role of regulatory b cells in neuroimmunologic disorders","volume":"94","author":"Han","year":"2016","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.phrs.2019.104408_bib0515","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s12974-018-1334-y","article-title":"Restoration of regulatory B cell deficiency following alemtuzumab therapy in patients with relapsing multiple sclerosis","volume":"15","author":"Kim","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"10.1016\/j.phrs.2019.104408_bib0520","first-page":"5630","article-title":"Regulation of differentiation of peritoneal B-1a (CD5+) B cells. Activated peritoneal macrophages release prostaglandin E2, which inhibits IgM secretion by peritoneal B-1a cells","volume":"154","author":"Chace","year":"1995","journal-title":"J. Immunol. (Baltimore, Md.\u202f: 1950)"},{"key":"10.1016\/j.phrs.2019.104408_bib0525","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/nyas.12799","article-title":"Characteristics of natural antibody-secreting cells","volume":"1362","author":"Savage","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.phrs.2019.104408_bib0530","doi-asserted-by":"crossref","DOI":"10.1038\/s41541-018-0087-z","article-title":"Targeting of the Yersinia pestis F1 capsular antigen by innate-like B1b cells mediates a rapid protective response against bubonic plague","volume":"3","author":"Levy","year":"2018","journal-title":"NPJ Vaccines"},{"issue":"5","key":"10.1016\/j.phrs.2019.104408_bib0535","first-page":"2289","article-title":"PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism","volume":"194","author":"McKay","year":"2015","journal-title":"J. Immunol. (Baltimore, Md.\u202f: 1950)"},{"issue":"12","key":"10.1016\/j.phrs.2019.104408_bib0540","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1002\/art.25015","article-title":"A novel subpopulation of B-1 cells is enriched with autoreactivity in normal and lupus-prone mice","volume":"60","author":"Zhong","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.phrs.2019.104408_bib0545","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/eji.200940050","article-title":"Class switching and consecutive loss of dsDNA-reactive B1a B cells from the peritoneal cavity during murine lupus development","volume":"40","author":"Enghard","year":"2010","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.phrs.2019.104408_bib0550","first-page":"3628","article-title":"Defective B1 cell homing to the peritoneal cavity and preferential recruitment of B1 cells in the target organs in a murine model for systemic lupus erythematosus","volume":"172","author":"Ito","year":"2004","journal-title":"J. Immunol. (Baltimore, Md.\u202f: 1950)"},{"issue":"12","key":"10.1016\/j.phrs.2019.104408_bib0555","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1002\/eji.200425373","article-title":"Aberrant B1 cell migration into the thymus results in activation of CD4 T cells through its potent antigen-presenting activity in the development of murine lupus","volume":"34","author":"Sato","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phrs.2019.104408_bib0560","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2741\/2188","article-title":"Aberrant B1 cell trafficking in a murine model for lupus","volume":"12","author":"Ishikawa","year":"2007","journal-title":"Front. Biosci."},{"issue":"7","key":"10.1016\/j.phrs.2019.104408_bib0565","first-page":"4393","article-title":"B cell subsets contribute to renal injury and renal protection after ischemia\/reperfusion","volume":"185","author":"Renner","year":"2010","journal-title":"J. Immunol. (Baltimore, Md.\u202f: 1950)"},{"key":"10.1016\/j.phrs.2019.104408_bib0570","article-title":"Natural immunoglobulin M initiates an inflammatory response important for both hepatic ischemia reperfusion injury and regeneration in mice","author":"Marshall","year":"2017","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"3","key":"10.1016\/j.phrs.2019.104408_bib0575","first-page":"1717","article-title":"Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity","volume":"181","author":"Kerfoot","year":"2008","journal-title":"J. Immunol. (Baltimore, Md.\u202f: 1950)"},{"issue":"Pt 10","key":"10.1016\/j.phrs.2019.104408_bib0580","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/brain\/awu205","article-title":"Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation","volume":"137","author":"Beltran","year":"2014","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.phrs.2019.104408_bib0585","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.clim.2010.06.007","article-title":"Immunological mechanisms that associate with oligoclonal IgM band synthesis in multiple sclerosis","volume":"137","author":"Villar","year":"2010","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2019.104408_bib0590","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12974-017-0894-6","article-title":"Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury, drive secondary injury by activating complement","volume":"14","author":"Narang","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.phrs.2019.104408_bib0595","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1002\/eji.200737296","article-title":"Reciprocal generation of Th1\/Th17 and T(reg) cells by B1 and B2 B cells","volume":"37","author":"Zhong","year":"2007","journal-title":"Eur. J. Immunol."},{"issue":"49","key":"10.1016\/j.phrs.2019.104408_bib0600","doi-asserted-by":"crossref","first-page":"20077","DOI":"10.1073\/pnas.1212428109","article-title":"Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions","volume":"109","author":"Wang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.phrs.2019.104408_bib0605","doi-asserted-by":"crossref","first-page":"194","DOI":"10.5604\/17322693.1197370","article-title":"[The role of IRA B cells in selected inflammatory processes]","volume":"70","author":"Zasada","year":"2016","journal-title":"Postepy Hig. Med. Dosw. (Online)"},{"issue":"6","key":"10.1016\/j.phrs.2019.104408_bib0610","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1084\/jem.20131471","article-title":"Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis","volume":"211","author":"Weber","year":"2014","journal-title":"J. Exp. Med."},{"issue":"6068","key":"10.1016\/j.phrs.2019.104408_bib0615","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1215173","article-title":"Innate response activator B cells protect against microbial sepsis","volume":"335","author":"Rauch","year":"2012","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.phrs.2019.104408_bib0620","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/ATVBAHA.113.303097","article-title":"Interleukin-3\/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency","volume":"34","author":"Wang","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6227","key":"10.1016\/j.phrs.2019.104408_bib0625","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.aaa4268","article-title":"Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis","volume":"347","author":"Weber","year":"2015","journal-title":"Science"},{"issue":"5940","key":"10.1016\/j.phrs.2019.104408_bib0630","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites","volume":"325","author":"Swirski","year":"2009","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2019.104408_bib0635","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41572-018-0041-4","article-title":"Multiple sclerosis, nature reviews","volume":"4","author":"Filippi","year":"2018","journal-title":"Disease Primers"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2019.104408_bib0640","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jneuroim.2011.08.019","article-title":"Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive\/memory Breg ratio during a relapse but not in remission","volume":"239","author":"Knippenberg","year":"2011","journal-title":"J. Neuroimmunol."},{"issue":"5","key":"10.1016\/j.phrs.2019.104408_bib0645","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.4049\/jimmunol.1402029","article-title":"IFN-\u03b2 treatment requires B cells for efficacy in Neuroautoimmunity","volume":"194","author":"Schubert","year":"2015","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2019.104408_bib0650","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/acn3.155","article-title":"Fingolimod treatment promotes regulatory phenotype and function of B cells","volume":"2","author":"Grutzke","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2019.104408_bib0655","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10875-009-9327-3","article-title":"B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis","volume":"30","author":"Thompson","year":"2010","journal-title":"J. Clin. Immunol."},{"issue":"7","key":"10.1016\/j.phrs.2019.104408_bib0660","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1111\/j.1600-6143.2012.04012.x","article-title":"B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of na\u00efve B cells","volume":"12","author":"Heidt","year":"2012","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.phrs.2019.104408_bib0665","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaut.2016.03.012","article-title":"Fingolimod therapy modulates circulating B cell composition, increases B regulatory subsets and production of IL-10 and TGFbeta in patients with Multiple Sclerosis","volume":"70","author":"Blumenfeld","year":"2016","journal-title":"J. Autoimmun."},{"issue":"9","key":"10.1016\/j.phrs.2019.104408_bib0670","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1182\/blood-2007-10-120071","article-title":"Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells","volume":"111","author":"Kunisawa","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.phrs.2019.104408_bib0675","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbpb.2012.05.006","article-title":"The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death, Comparative biochemistry and physiology","volume":"163","author":"Van Brocklyn","year":"2012","journal-title":"Part B, Biochemistry & molecular biology"},{"issue":"1","key":"10.1016\/j.phrs.2019.104408_bib0680","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/01.RES.0000253900.66640.34","article-title":"Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis","volume":"100","author":"Pchejetski","year":"2007","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.phrs.2019.104408_bib0685","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000360","article-title":"Both cladribine and alemtuzumab may effect MS via B-cell depletion","volume":"4","author":"Baker","year":"2017","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.phrs.2019.104408_bib0690","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus, Nature reviews","volume":"2","author":"Kaul","year":"2016","journal-title":"Disease primers"},{"issue":"4","key":"10.1016\/j.phrs.2019.104408_bib0695","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3109\/03009742.2015.1126346","article-title":"Decreased IL-10(+) regulatory B cells (Bregs) in lupus nephritis patients","volume":"45","author":"Heinemann","year":"2016","journal-title":"Scand. J. 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Preferential homing of rheumatoid factor-producing B cell precursors in the synovial fluid","volume":"35","author":"Moynier","year":"1992","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.phrs.2019.104408_bib0875","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/art.1780330306","article-title":"The relationship between CD5-expressing B lymphocytes and serologic abnormalities in rheumatoid arthritis patients and their relatives","volume":"33","author":"Youinou","year":"1990","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.phrs.2019.104408_bib0880","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1749-6632.1997.tb52071.x","article-title":"Rheumatoid factor autoantibodies in health and disease","volume":"815","author":"Mageed","year":"1997","journal-title":"Ann. N. Y. Acad. 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Biol."},{"issue":"2","key":"10.1016\/j.phrs.2019.104408_bib1030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.molcel.2005.12.006","article-title":"A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons","volume":"21","author":"Riccio","year":"2006","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.phrs.2019.104408_bib1035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.bbagen.2011.05.008","article-title":"S-nitrosylation in the regulation of gene transcription","volume":"1820","author":"Sha","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"10.1016\/j.phrs.2019.104408_bib1040","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","article-title":"The role of the transcription factor CREB in immune function","volume":"185","author":"Wen","year":"2010","journal-title":"J. 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