{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T23:50:47Z","timestamp":1787356247508,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004776","name":"Faculty of Medicine, Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004776","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.phrs.2019.104517","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T17:10:56Z","timestamp":1572801056000},"page":"104517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Plumbagin inhibits cancer stem-like cells, angiogenesis and suppresses cell proliferation and invasion by targeting Wnt\/\u03b2-catenin pathway in endocrine resistant breast cancer"],"prefix":"10.1016","volume":"150","author":[{"given":"Nithidol","family":"Sakunrangsit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-5750","authenticated-orcid":false,"given":"Wannarasmi","family":"Ketchart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phrs.2019.104517_bib0005","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1634\/theoncologist.2014-0372","article-title":"Defining breast cancer intrinsic subtypes by quantitative receptor expression","volume":"20","author":"Cheang","year":"2015","journal-title":"Oncologist"},{"issue":"4","key":"10.1016\/j.phrs.2019.104517_bib0010","first-page":"290","article-title":"Breast cancer-Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual","volume":"67","author":"Giuliano","year":"2017","journal-title":"CA. Cancer J. Clin."},{"issue":"8","key":"10.1016\/j.phrs.2019.104517_bib0015","doi-asserted-by":"crossref","first-page":"R337","DOI":"10.1530\/ERC-16-0121","article-title":"Endocrine resistance in hormone-responsive breast cancer: mechanisms and therapeutic strategies","volume":"23","author":"Murphy","year":"2016","journal-title":"Endocrine-Related Cancer"},{"issue":"30","key":"10.1016\/j.phrs.2019.104517_bib0020","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1038\/onc.2013.368","article-title":"c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer","volume":"33","author":"Nair","year":"2014","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.phrs.2019.104517_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183578","article-title":"Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells","volume":"12","author":"Yin","year":"2017","journal-title":"PloS One"},{"issue":"6","key":"10.1016\/j.phrs.2019.104517_bib0030","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.tranon.2017.07.007","article-title":"Isolation of stem-like cancer cells in primary endometrial cancer using cell surface markers CD133 and CXCR4","volume":"10","author":"Sun","year":"2017","journal-title":"Transl. Oncol."},{"issue":"16","key":"10.1016\/j.phrs.2019.104517_bib0035","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.3760\/cma.j.issn.0366-6999.20130227","article-title":"Tamoxifen-resistant breast cancer cells possess cancer stem-like cell properties","volume":"126","author":"Liu","year":"2013","journal-title":"Chin. Med. J. (Engl.)"},{"issue":"12","key":"10.1016\/j.phrs.2019.104517_bib0040","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/ptr.5702","article-title":"Plumbagin enhances tamoxifen sensitivity and inhibits tumor invasion in endocrine resistant breast cancer through EMT regulation","volume":"30","author":"Sakunrangsit","year":"2016","journal-title":"Phytother. Res."},{"issue":"16","key":"10.1016\/j.phrs.2019.104517_bib0045","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1158\/0008-5472.CAN-14-3265","article-title":"Diverse targets of beta-catenin during the epithelial-mesenchymal transition define cancer stem cells and predict disease relapse","volume":"75","author":"Chang","year":"2015","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.phrs.2019.104517_bib0050","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317712617","article-title":"The Wnt\/beta-catenin and PI3K\/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation","volume":"39","author":"Song","year":"2017","journal-title":"Tumour Biol."},{"issue":"2","key":"10.1016\/j.phrs.2019.104517_bib0055","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/carcin\/bgn279","article-title":"Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells","volume":"30","author":"Su","year":"2009","journal-title":"Carcinogenesis"},{"issue":"10","key":"10.1016\/j.phrs.2019.104517_bib0060","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1158\/1541-7786.MCR-07-2172","article-title":"An autocrine VEGF\/VEGFR2 and p38 signaling loop confers resistance to 4-hydroxytamoxifen in MCF-7 breast cancer cells","volume":"6","author":"Aesoy","year":"2008","journal-title":"Mol. Cancer Res."},{"issue":"10","key":"10.1016\/j.phrs.2019.104517_bib0065","first-page":"12357","article-title":"Wnt\/beta-catenin pathway is required for epithelial to mesenchymal transition in CXCL12 over expressed breast cancer cells","volume":"8","author":"Shan","year":"2015","journal-title":"Int. J. Clin. Exp. Path."},{"issue":"4","key":"10.1016\/j.phrs.2019.104517_bib0070","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.3892\/ol.2017.6754","article-title":"Activation of the Wnt\/beta-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of twist","volume":"14","author":"Sun","year":"2017","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.phrs.2019.104517_bib0075","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1136\/gutjnl-2016-313185","article-title":"Colorectal cancer cells use the negative feedback regulators of WNT signalling to activate epithelial-mesenchymal transition pathways","volume":"66","author":"Tulchinsky","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.phrs.2019.104517_bib0080","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3892\/ol.2015.3957","article-title":"Expression profile and clinical significance of wnt signaling in human gliomas","volume":"15","author":"Zhang","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.phrs.2019.104517_bib0085","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/1471-2407-13-174","article-title":"The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer","volume":"13","author":"Loh","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.phrs.2019.104517_bib0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13058-015-0579-y","volume":"17","author":"Yuan","year":"2015","journal-title":"Breast Cancer Res."},{"issue":"Pt 13","key":"10.1016\/j.phrs.2019.104517_bib0095","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1242\/jcs.021667","article-title":"E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression","volume":"121","author":"Solanas","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phrs.2019.104517_bib0100","article-title":"E-cadherin\/beta-catenin complex and the epithelial barrier","volume":"2011","author":"Tian","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"issue":"1","key":"10.1016\/j.phrs.2019.104517_bib0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jcb.23350","article-title":"The Wnt\/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer","volume":"113","author":"King","year":"2012","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.phrs.2019.104517_bib0110","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.1038\/oncsis.2017.14","article-title":"Wnt signaling in triple-negative breast cancer","volume":"6","author":"Pohl","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.phrs.2019.104517_bib0115","doi-asserted-by":"crossref","first-page":"12465","DOI":"10.1038\/srep12465","article-title":"Blockade of Wnt\/beta-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype","volume":"5","author":"Jang","year":"2015","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.phrs.2019.104517_bib0120","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2019.104517_bib0125","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/bcr2789","article-title":"Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression","volume":"13","author":"May","year":"2011","journal-title":"Breast Cancer Res."},{"issue":"9","key":"10.1016\/j.phrs.2019.104517_bib0130","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.4161\/cbt.5.9.3151","article-title":"Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades","volume":"5","author":"Katoh","year":"2006","journal-title":"Cancer Biol. Ther."},{"issue":"16","key":"10.1016\/j.phrs.2019.104517_bib0135","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1158\/1078-0432.CCR-10-2727","article-title":"FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo","volume":"17","author":"Sharpe","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.phrs.2019.104517_bib0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1684\/ecn.2009.0175","article-title":"Anti-FGF2 approaches as a strategy to compensate resistance to anti-VEGF therapy: long-pentraxin 3 as a novel antiangiogenic FGF2-antagonist","volume":"20","author":"Alessi","year":"2009","journal-title":"Eur. Cytokine Netw."},{"issue":"10","key":"10.1016\/j.phrs.2019.104517_bib0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185736","article-title":"Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions","volume":"12","author":"Aukes","year":"2017","journal-title":"PloS One"},{"issue":"22","key":"10.1016\/j.phrs.2019.104517_bib0150","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJM199811263392207","article-title":"Tamoxifen in the treatment of breast cancer","volume":"339","author":"Osborne","year":"1998","journal-title":"New Engl. J. Med."},{"issue":"6","key":"10.1016\/j.phrs.2019.104517_bib0155","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/med.20235","article-title":"Perspectives on medicinal properties of plumbagin and its analogs","volume":"32","author":"Padhye","year":"2012","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2019.104517_bib0160","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40360-016-0094-5","article-title":"Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin","volume":"17","author":"Sumsakul","year":"2016","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.phrs.2019.104517_bib0165","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.molonc.2012.12.001","article-title":"Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model","volume":"7","author":"Hafeez","year":"2013","journal-title":"Mol. Oncol."},{"issue":"4b","key":"10.1016\/j.phrs.2019.104517_bib0170","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1476-5381.2011.01532.x","article-title":"Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2","volume":"165","author":"Lai","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"16","key":"10.1016\/j.phrs.2019.104517_bib0175","first-page":"3486","article-title":"MCF7\/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen","volume":"57","author":"Brunner","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2019.104517_bib0180","first-page":"14","article-title":"Cancer stem cells as a potential therapeutic target in breast cancer","volume":"1","author":"Zhang","year":"2014","journal-title":"Stem Cell Investig."},{"key":"10.1016\/j.phrs.2019.104517_bib0185","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/1479-5876-11-280","article-title":"Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells","volume":"11","author":"Bilir","year":"2013","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phrs.2019.104517_bib0190","doi-asserted-by":"crossref","DOI":"10.1111\/jphp.13176","article-title":"Ethoxy mansonone G as an anticancer agent in estrogen receptor-positive and endocrine-resistant breast cancer","author":"Chonsut","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"issue":"5","key":"10.1016\/j.phrs.2019.104517_bib0195","first-page":"6233","article-title":"Establishment of a murine breast tumor model by subcutaneous or orthotopic implantation","volume":"15","author":"Zhang","year":"2018","journal-title":"Oncol. Lett."},{"issue":"5","key":"10.1016\/j.phrs.2019.104517_bib0200","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3892\/ol.2013.1256","article-title":"Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt\/beta-catenin pathway in gastric cancer","volume":"5","author":"Mo","year":"2013","journal-title":"Oncol. Lett."},{"issue":"19","key":"10.1016\/j.phrs.2019.104517_bib0205","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.1158\/1078-0432.CCR-11-0659","article-title":"Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis","volume":"17","author":"Lieu","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.phrs.2019.104517_bib0210","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.molcel.2011.06.020","article-title":"FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1\/KDM2B-miR-101-EZH2 pathway","volume":"43","author":"Kottakis","year":"2011","journal-title":"Mol. Cell"},{"issue":"48","key":"10.1016\/j.phrs.2019.104517_bib0215","doi-asserted-by":"crossref","first-page":"45847","DOI":"10.1074\/jbc.M209354200","article-title":"Fibroblast growth factor-2 induces Lef\/Tcf-dependent transcription in human endothelial cells","volume":"277","author":"Holnthoner","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.phrs.2019.104517_bib0220","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1158\/0008-5472.CAN-15-2616","article-title":"Endoplasmic reticulum stress protein GRP78 modulates lipid metabolism to control drug sensitivity and antitumor immunity in breast cancer","volume":"76","author":"Cook","year":"2016","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.phrs.2019.104517_bib0225","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1158\/1078-0432.CCR-13-3227","article-title":"Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer","volume":"20","author":"Cook","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.phrs.2019.104517_bib0230","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1158\/1078-0432.CCR-17-2776","article-title":"Reactivation of cAMP pathway by PDE4D inhibition represents a novel druggable axis for overcoming tamoxifen resistance in ER-positive breast cancer","volume":"24","author":"Mishra","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"19","key":"10.1016\/j.phrs.2019.104517_bib0235","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1158\/0008-5472.CAN-12-1248","article-title":"Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K\/AKT pathway","volume":"72","author":"Ramaswamy","year":"2012","journal-title":"Cancer Res."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818320358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661818320358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:03:15Z","timestamp":1760911395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661818320358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":47,"alternative-id":["S1043661818320358"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2019.104517","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plumbagin inhibits cancer stem-like cells, angiogenesis and suppresses cell proliferation and invasion by targeting Wnt\/\u03b2-catenin pathway in endocrine resistant breast cancer","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2019.104517","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104517"}}