{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:27:50Z","timestamp":1786408070997,"version":"build-2736575974"},"reference-count":123,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.phrs.2019.104617","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T14:29:59Z","timestamp":1577197799000},"page":"104617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"special_numbering":"C","title":["The gut-liver-kidney axis: Novel regulator of fatty liver associated chronic kidney disease"],"prefix":"10.1016","volume":"152","author":[{"given":"Desh","family":"Raj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawna","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Lahiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikant R.","family":"Mulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0005","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.celrep.2015.03.049","article-title":"The gut microbiota of rural papua new guineans: composition, diversity patterns, and ecological processes","volume":"11","author":"Martinez","year":"2015","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11906-017-0727-0","article-title":"Gut microbiome in chronic kidney disease","volume":"19","author":"Armani","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"issue":"10","key":"10.1016\/j.phrs.2019.104617_bib0015","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/cvr\/cvz135","article-title":"The intestinal microbiota and cardiovascular disease","volume":"115","author":"Katsimichas","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.phrs.2019.104617_bib0020","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/eurheartj\/eht271","article-title":"The heart and the gut","volume":"35","author":"Rogler","year":"2014","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.phrs.2019.104617_bib0025","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1136\/gutjnl-2012-303816","article-title":"Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice","volume":"62","author":"Le Roy","year":"2013","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.phrs.2019.104617_bib0030","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","article-title":"The role of the gut microbiota in NAFLD","volume":"13","author":"Leung","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"16","key":"10.1016\/j.phrs.2019.104617_bib0035","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.jacc.2007.07.016","article-title":"Altered intestinal function in patients with chronic heart failure","volume":"50","author":"Sandek","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.phrs.2019.104617_bib0040","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jacc.2014.06.1179","article-title":"Intestinal blood flow in patients with chronic heart failure: a link with bacterial growth, gastrointestinal symptoms, and cachexia","volume":"64","author":"Sandek","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phrs.2019.104617_bib0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.phrs.2018.04.023","article-title":"Linking gut microbiota to cardiovascular disease and hypertension: lessons from chronic kidney disease","volume":"133","author":"Meijers","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"6230","key":"10.1016\/j.phrs.2019.104617_bib0050","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.aaa4972","article-title":"Cancer and the microbiota","volume":"348","author":"Garrett","year":"2015","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00281-014-0454-4","article-title":"The gut microbiota and inflammatory bowel disease","volume":"37","author":"Matsuoka","year":"2015","journal-title":"Semin. Immunopathol."},{"issue":"6467","key":"10.1016\/j.phrs.2019.104617_bib0060","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1126\/science.aav3487","article-title":"Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy","volume":"366","author":"Gil-Cruz","year":"2019","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0065","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1038\/s41598-018-23014-0","article-title":"Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study","volume":"8","author":"Jang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2019.104617_bib0070","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/847539","article-title":"Chronic kidney disease and nonalcoholic Fatty liver disease-is there a link?","volume":"2014","author":"Orlic","year":"2014","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.phrs.2019.104617_bib0075","first-page":"1","article-title":"The microbiome in benign renal tissue and in renal cell carcinoma","author":"Heidler","year":"2019","journal-title":"Urol. Int."},{"issue":"5","key":"10.1016\/j.phrs.2019.104617_bib0080","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3945\/jn.110.135657","article-title":"Regulation of tight junction permeability by intestinal bacteria and dietary components","volume":"141","author":"Ulluwishewa","year":"2011","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0085","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2019.104617_bib0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fvets.2015.00057","article-title":"Regulation of the intestinal barrier function by host defense peptides","volume":"2","author":"Robinson","year":"2015","journal-title":"Front. Vet. Sci."},{"issue":"8","key":"10.1016\/j.phrs.2019.104617_bib0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s12276-018-0126-x","article-title":"Mechanisms regulating intestinal barrier integrity and its pathological implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0100","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj2630597","article-title":"Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance","volume":"263","author":"Stevenson","year":"1989","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0105","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00018-012-1070-x","article-title":"Regulation of intestinal epithelial permeability by tight junctions","volume":"70","author":"Suzuki","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0110","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbagen.2014.05.003","article-title":"Mucins: a biologically relevant glycan barrier in mucosal protection","volume":"1850","author":"Corfield","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0115","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/mi.2008.5","article-title":"Mucins in the mucosal barrier to infection","volume":"1","author":"Linden","year":"2008","journal-title":"Mucosal Immunol."},{"issue":"5","key":"10.1016\/j.phrs.2019.104617_bib0120","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0125","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/j.gastro.2004.04.015","article-title":"Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C","volume":"127","author":"Cario","year":"2004","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0130","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/iub.175","article-title":"Regulation and roles for claudin-family tight junction proteins","volume":"61","author":"Findley","year":"2009","journal-title":"IUBMB Life"},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0135","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1053\/gast.2001.27224","article-title":"Probiotic bacteria enhance murine and human intestinal epithelial barrier function","volume":"121","author":"Madsen","year":"2001","journal-title":"Gastroenterology"},{"issue":"Pt 10","key":"10.1016\/j.phrs.2019.104617_bib0140","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1242\/jcs.02915","article-title":"Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure","volume":"119","author":"Shen","year":"2006","journal-title":"J. Cell. Sci."},{"issue":"12","key":"10.1016\/j.phrs.2019.104617_bib0145","doi-asserted-by":"crossref","first-page":"e1308","DOI":"10.1371\/journal.pone.0001308","article-title":"Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity","volume":"2","author":"Ukena","year":"2007","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0150","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1053\/gast.2001.27060","article-title":"Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia","volume":"121","author":"Walsh","year":"2001","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0155","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1462-5822.2006.00836.x","article-title":"Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair","volume":"9","author":"Zyrek","year":"2007","journal-title":"Cell. Microbiol."},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0160","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1053\/j.gastro.2005.12.015","article-title":"Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells","volume":"130","author":"Resta-Lenert","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2019.104617_bib0165","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.2741\/3413","article-title":"Mechanism of cytokine modulation of epithelial tight junction barrier","volume":"14","author":"Al-Sadi","year":"2009","journal-title":"Front. Biosci."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.105.085449","article-title":"The role of protein kinase C isoforms in modulating injury and repair of the intestinal barrier","volume":"316","author":"Farhadi","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"Pt 1","key":"10.1016\/j.phrs.2019.104617_bib0175","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/BJ20050959","article-title":"MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide","volume":"393","author":"Basuroy","year":"2006","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.phrs.2019.104617_bib0180","first-page":"G851","article-title":"Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier","volume":"298","author":"Karczewski","year":"2010","journal-title":"Am. J. Physiol."},{"issue":"23","key":"10.1016\/j.phrs.2019.104617_bib0185","doi-asserted-by":"crossref","first-page":"10629","DOI":"10.1073\/pnas.92.23.10629","article-title":"Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia","volume":"92","author":"Nusrat","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2019.104617_bib0190","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.trsl.2016.07.005","article-title":"Gut microbiome and liver disease","volume":"179","author":"Betrapally","year":"2017","journal-title":"Transl. Res."},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0195","article-title":"Gut(-)Liver axis: how do gut bacteria influence the liver?","volume":"6","author":"Konturek","year":"2018","journal-title":"Med. Sci."},{"issue":"7","key":"10.1016\/j.phrs.2019.104617_bib0200","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/17474124.2018.1481747","article-title":"Bacterial translocation in patients with liver cirrhosis: physiology, clinical consequences, and practical implications","volume":"12","author":"Ponziani","year":"2018","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0205","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3350\/cmh.2017.0067","article-title":"Microbiota, a key player in alcoholic liver disease","volume":"24","author":"Cassard","year":"2018","journal-title":"Clin. Mol. Hepatol."},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0210","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/apt.14397","article-title":"Review article: the gut microbiome as a therapeutic target in the pathogenesis and treatment of chronic liver disease","volume":"47","author":"Woodhouse","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/hep.30036","article-title":"Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease","volume":"69","author":"Ponziani","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.phrs.2019.104617_bib0220","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.metabol.2017.03.013","article-title":"Non-alcoholic fatty liver disease: an update with special focus on the role of gut microbiota","volume":"71","author":"Doulberis","year":"2017","journal-title":"Metab. Clin. Exp."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0225","doi-asserted-by":"crossref","first-page":"12200","DOI":"10.1038\/s41598-017-11744-6","article-title":"Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD","volume":"7","author":"Pierantonelli","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0230","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1681\/ASN.2015111285","article-title":"Intestinal dysbiosis, barrier dysfunction, and bacterial translocation account for CKD-related systemic inflammation","volume":"28","author":"Andersen","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0235","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000360010","article-title":"Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD","volume":"39","author":"Wong","year":"2014","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.phrs.2019.104617_bib0240","doi-asserted-by":"crossref","DOI":"10.1038\/s41581-019-0172-1","article-title":"Intestinal microbiome and fitness in kidney disease","author":"Meijers","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"9","key":"10.1016\/j.phrs.2019.104617_bib0245","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1007\/s10620-014-3202-7","article-title":"Gut bacterial translocation may aggravate microinflammation in hemodialysis patients","volume":"59","author":"Shi","year":"2014","journal-title":"Dig. Dis. Sci."},{"issue":"9","key":"10.1016\/j.phrs.2019.104617_bib0250","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.2215\/CJN.03100315","article-title":"Associations of soluble CD14 and endotoxin with mortality, cardiovascular disease, and progression of kidney disease among patients with CKD","volume":"10","author":"Poesen","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0255","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/imm.12231","article-title":"The microbiome and regulation of mucosal immunity","volume":"142","author":"McDermott","year":"2014","journal-title":"Immunology"},{"issue":"7","key":"10.1016\/j.phrs.2019.104617_bib0260","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/ndt\/gft091","article-title":"Renohepatic crosstalk: does acute kidney injury cause liver dysfunction?","volume":"28","author":"Lane","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0265","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-0032-1301735","article-title":"Hepatorenal syndrome: a critical update","volume":"33","author":"Wadei","year":"2012","journal-title":"Semin. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0270","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1053\/j.jrn.2004.10.003","article-title":"Dyslipidemia and nephrotic syndrome: recent advances","volume":"15","author":"Kronenberg","year":"2005","journal-title":"J. Ren. Nutr."},{"issue":"12","key":"10.1016\/j.phrs.2019.104617_bib0275","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.dld.2015.08.004","article-title":"Epidemiological modifiers of non-alcoholic fatty liver disease: focus on high-risk groups","volume":"47","author":"Non-alcoholic Fatty Liver Disease Study","year":"2015","journal-title":"Dig. Liver Dis."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0280","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/j.ajkd.2014.05.019","article-title":"CKD and nonalcoholic fatty liver disease","volume":"64","author":"Targher","year":"2014","journal-title":"Am. J. Kidney Dis."},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0285","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00041552-200103000-00007","article-title":"Dyslipidemia and renal disease: pathogenesis and clinical consequences","volume":"10","author":"Wanner","year":"2001","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0290","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/MOL.0b013e32832dd832","article-title":"Dyslipidemia of kidney disease","volume":"20","author":"Attman","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"issue":"5","key":"10.1016\/j.phrs.2019.104617_bib0295","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/01.HYP.0000102971.85504.7c","volume":"42","author":"Sarnak","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2019.104617_bib0300","first-page":"52","article-title":"Alteration of fatty acid oxidation in tubular epithelial cells: from acute kidney injury to renal fibrogenesis","volume":"2","author":"Simon","year":"2015","journal-title":"Front. Med. (Lausanne)"},{"issue":"5","key":"10.1016\/j.phrs.2019.104617_bib0305","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrneph.2017.16","article-title":"Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease","volume":"13","author":"Targher","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"issue":"5","key":"10.1016\/j.phrs.2019.104617_bib0310","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1159\/000343885","article-title":"Association between nonalcoholic liver disease and chronic kidney disease: an ultrasound analysis from NHANES 1988-1994","volume":"36","author":"Sirota","year":"2012","journal-title":"Am. J. Nephrol."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0315","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.metabol.2007.11.022","article-title":"Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men","volume":"57","author":"Chang","year":"2008","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0320","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/hep.26717","article-title":"Extrahepatic complications of nonalcoholic fatty liver disease","volume":"59","author":"Armstrong","year":"2014","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0325","doi-asserted-by":"crossref","first-page":"92","DOI":"10.11613\/BM.2012.010","article-title":"Nonalcoholic fatty liver disease associated with impairment of kidney function in nondiabetes population","volume":"22","author":"Li","year":"2012","journal-title":"Biochem. Med. (Zagreb)"},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0330","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s12072-015-9690-5","article-title":"High FIB-4 index as an independent risk factor of prevalent chronic kidney disease in patients with nonalcoholic fatty liver disease","volume":"10","author":"Xu","year":"2016","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.phrs.2019.104617_bib0335","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1111\/j.1523-1755.2005.09503.x","article-title":"Risks of chronic metabolic acidosis in patients with chronic kidney disease","volume":"95","author":"Kopple","year":"2005","journal-title":"Kidney Int. Suppl."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0340","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1523-1755.2002.00409.x","article-title":"The flux of arginine after ischemia-reperfusion in the rat kidney","volume":"62","author":"Prins","year":"2002","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0345","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.taap.2011.05.015","article-title":"Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: investigation of nicotinic acid receptor agonists","volume":"255","author":"Zgoda-Pols","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0350","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000092919","article-title":"Effects of indoxylsulfate on the in vitro hepatic metabolism of various compounds using human liver microsomes and hepatocytes","volume":"103","author":"Hanada","year":"2006","journal-title":"Nephron Physiol."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0355","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/00365520500292962","article-title":"Determinants of the renin-angiotensin-aldosterone system in cirrhosis with special emphasis on the central blood volume","volume":"41","author":"Moller","year":"2006","journal-title":"Scand. J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0360","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/ndt\/gfq580","article-title":"p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease","volume":"26","author":"Wu","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"issue":"8","key":"10.1016\/j.phrs.2019.104617_bib0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134590","article-title":"The role of liver in determining serum colon-derived uremic solutes","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0370","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2174\/1872312810666160719143703","article-title":"The uremic toxin Indoxyl-3-Sulfate induces CYP1A2 in primary human hepatocytes","volume":"10","author":"Liu","year":"2016","journal-title":"Drug Metab. Lett."},{"key":"10.1016\/j.phrs.2019.104617_bib0375","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900257","article-title":"Trimethylamine N-Oxide aggravates liver steatosis through modulation of bile acid metabolism and inhibition of farnesoid X receptor signaling in nonalcoholic fatty liver disease","author":"Tan","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0380","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/CIRCRESAHA.116.305360","article-title":"Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease","volume":"116","author":"Tang","year":"2015","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.phrs.2019.104617_bib0385","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1177\/2050640618804444","article-title":"Fecal SCFAs and SCFA-producing bacteria in gut microbiome of human NAFLD as a putative link to systemic T-cell activation and advanced disease","volume":"6","author":"Rau","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0390","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000356211","article-title":"Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release","volume":"89","author":"Kaji","year":"2014","journal-title":"Digestion"},{"issue":"12","key":"10.1016\/j.phrs.2019.104617_bib0395","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s12276-018-0183-1","article-title":"Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression","volume":"50","author":"Zhou","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0400","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41598-018-37019-2","article-title":"Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells","volume":"9","author":"Marinelli","year":"2019","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.phrs.2019.104617_bib0405","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.dld.2014.02.010","article-title":"Intestinal permeability is increased in children with non-alcoholic fatty liver disease, and correlates with liver disease severity","volume":"46","author":"Giorgio","year":"2014","journal-title":"Dig. Liver Dis."},{"issue":"7203","key":"10.1016\/j.phrs.2019.104617_bib0410","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000345969","article-title":"Role of urea in intestinal barrier dysfunction and disruption of epithelial tight junction in chronic kidney disease","volume":"37","author":"Vaziri","year":"2013","journal-title":"Am. J. Nephrol."},{"issue":"8","key":"10.1016\/j.phrs.2019.104617_bib0420","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/nep.12272","article-title":"Probiotic Bifidobacterium animalis subsp. lactis Bi-07 alleviates bacterial translocation and ameliorates microinflammation in experimental uraemia","volume":"19","author":"Wei","year":"2014","journal-title":"Nephrology (Carlton)"},{"issue":"6","key":"10.1016\/j.phrs.2019.104617_bib0425","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"Miele","year":"2009","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0430","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/apt.13860","article-title":"Improvement in liver histology due to lifestyle modification is independently associated with improved kidney function in patients with non-alcoholic steatohepatitis","volume":"45","author":"Vilar-Gomez","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0435","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s10787-018-0479-8","article-title":"Probiotic mixture of Lactobacillus and Bifidobacterium alleviates systemic adiposity and inflammation in non-alcoholic fatty liver disease rats through Gpr109a and the commensal metabolite butyrate","volume":"26","author":"Liang","year":"2018","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0440","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/ndt\/gfv353","article-title":"Gut Lactobacillus protects against the progression of renal damage by modulating the gut environment in rats","volume":"31","author":"Yoshifuji","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0445","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.kint.2016.09.040","article-title":"Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects","volume":"91","author":"Soleimani","year":"2017","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.phrs.2019.104617_bib0450","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.chom.2016.10.021","article-title":"Modulation of a circulating uremic solute via rational genetic manipulation of the gut microbiota","volume":"20","author":"Devlin","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0455","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/sj.ki.5001523","article-title":"Acarbose treatment lowers generation and serum concentrations of the protein-bound solute p-cresol: a pilot study","volume":"70","author":"Evenepoel","year":"2006","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0460","doi-asserted-by":"crossref","first-page":"F824","DOI":"10.1152\/ajprenal.00314.2017","article-title":"Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model","volume":"315","author":"Mishima","year":"2018","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.phrs.2019.104617_bib0465","doi-asserted-by":"crossref","DOI":"10.1177\/1756284819858470","article-title":"Insights into the evolving role of the gut microbiome in nonalcoholic fatty liver disease: rationale and prospects for therapeutic intervention","volume":"12","author":"Mouzaki","year":"2019","journal-title":"Therap. Adv. Gastroenterol."},{"key":"10.1016\/j.phrs.2019.104617_bib0470","doi-asserted-by":"crossref","DOI":"10.1093\/ndt\/gfz080","article-title":"The gut flora modulates intestinal barrier integrity but not progression of chronic kidney disease in hyperoxaluria-related nephrocalcinosis","author":"Konrad","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0475","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3748\/wjg.14.313","article-title":"Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats","volume":"14","author":"Wu","year":"2008","journal-title":"World J. Gastroenterol."},{"issue":"24","key":"10.1016\/j.phrs.2019.104617_bib0480","doi-asserted-by":"crossref","first-page":"38161","DOI":"10.18632\/oncotarget.16975","article-title":"Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice","volume":"8","author":"Hu","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0485","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13073-016-0297-9","article-title":"Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet","volume":"8","author":"Mahana","year":"2016","journal-title":"Genome Med."},{"issue":"6","key":"10.1016\/j.phrs.2019.104617_bib0490","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jhep.2008.01.035","article-title":"Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin","volume":"48","author":"Bergheim","year":"2008","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.phrs.2019.104617_bib0495","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1097\/MEG.0000000000001232","article-title":"Rifaximin in nonalcoholic fatty liver disease: hit multiple targets with a single shot","volume":"30","author":"Abdel-Razik","year":"2018","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.phrs.2019.104617_bib0500","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/MEG.0000000000000348","article-title":"Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease","volume":"27","author":"Gangarapu","year":"2015","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0505","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41598-017-01751-y","article-title":"Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.phrs.2019.104617_bib0510","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/hep.29646","article-title":"Restoration of a healthy intestinal microbiota normalizes portal hypertension in a rat model of nonalcoholic steatohepatitis","volume":"67","author":"Garcia-Lezana","year":"2018","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.phrs.2019.104617_bib0515","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molmed.2015.08.005","article-title":"Emerging liver-kidney interactions in nonalcoholic fatty liver disease","volume":"21","author":"Musso","year":"2015","journal-title":"Trends Mol. Med."},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0520","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/hep.23104","article-title":"Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice","volume":"50","author":"Osterreicher","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.phrs.2019.104617_bib0525","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.peptides.2013.05.010","article-title":"Oral Angiotensin-(1-7) prevented obesity and hepatic inflammation by inhibition of resistin\/TLR4\/MAPK\/NF-kappaB in rats fed with high-fat diet","volume":"46","author":"Santos","year":"2013","journal-title":"Peptides"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2019.104617_bib0530","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mce.2014.05.024","article-title":"The ACE2\/Ang-(1-7)\/Mas axis can inhibit hepatic insulin resistance","volume":"393","author":"Cao","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"issue":"5","key":"10.1016\/j.phrs.2019.104617_bib0535","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S2213-8587(14)70065-8","article-title":"Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease","volume":"2","author":"de Vries","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.phrs.2019.104617_bib0540","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.fct.2013.11.015","article-title":"Monascin and ankaflavin act as natural AMPK activators with PPARalpha agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL\/6 mice","volume":"64","author":"Hsu","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.phrs.2019.104617_bib0545","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/ki.2013.462","article-title":"Regulation of lipid accumulation by AMP-activated kinase [corrected] in high fat diet-induced kidney injury","volume":"85","author":"Decleves","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2019.104617_bib0550","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tiv.2019.01.003","article-title":"Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity","volume":"56","author":"Weigand","year":"2019","journal-title":"Toxicol. In Vitro"},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0555","doi-asserted-by":"crossref","first-page":"F391","DOI":"10.1152\/ajprenal.00445.2009","article-title":"Renin-angiotensin system activation in renal adipogenesis","volume":"298","author":"Sui","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"21","key":"10.1016\/j.phrs.2019.104617_bib0560","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1056\/NEJMcibr1608564","article-title":"Nephron protection in diabetic kidney disease","volume":"375","author":"Anders","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2019.104617_bib0565","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2015.02.009","article-title":"Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats","volume":"754","author":"Hayashizaki-Someya","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2019.104617_bib0570","doi-asserted-by":"crossref","first-page":"S211","DOI":"10.1016\/S0168-8278(15)30055-6","article-title":"Remogliflozin etabonate reduces insulin resistance and liver function enzymes: role for treatment of nash","volume":"62","author":"Wilkison","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2019.104617_bib0575","article-title":"Hepatic fat deposition is improved more with SGLT2 inhibitor luseogliflozin compared with sitagliptin: a randomised, crossover, controlled study using computed tomography","volume":"58","author":"Fushimi","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2019.104617_bib0580","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/1471-2180-10-316","article-title":"Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation","volume":"10","author":"Anderson","year":"2010","journal-title":"BMC Microbiol."},{"issue":"2","key":"10.1016\/j.phrs.2019.104617_bib0585","first-page":"184","article-title":"Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function","volume":"309","author":"Anderson","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"issue":"5","key":"10.1016\/j.phrs.2019.104617_bib0590","doi-asserted-by":"crossref","first-page":"G1025","DOI":"10.1152\/ajpgi.90227.2008","article-title":"Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function","volume":"295","author":"Ewaschuk","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2019.104617_bib0595","doi-asserted-by":"crossref","first-page":"e2369","DOI":"10.1371\/journal.pone.0002369","article-title":"Salmonella type III effector AvrA stabilizes cell tight junctions to inhibit inflammation in intestinal epithelial cells","volume":"3","author":"Liao","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2019.104617_bib0600","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2180-9-63","article-title":"L. plantarum prevents enteroinvasive Escherichia coli-induced tight junction proteins changes in intestinal epithelial cells","volume":"9","author":"Qin","year":"2009","journal-title":"BMC Microbiol."},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0605","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12929-018-0483-8","article-title":"Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis","volume":"25","author":"Yu","year":"2018","journal-title":"J. Biomed. Sci."},{"issue":"7195","key":"10.1016\/j.phrs.2019.104617_bib0610","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nature07008","article-title":"A microbial symbiosis factor prevents intestinal inflammatory disease","volume":"453","author":"Mazmanian","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2019.104617_bib0615","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat. Med."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181931905X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181931905X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:08:02Z","timestamp":1760911682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366181931905X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":123,"alternative-id":["S104366181931905X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2019.104617","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The gut-liver-kidney axis: Novel regulator of fatty liver associated chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2019.104617","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104617"}}