{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:29:09Z","timestamp":1793071749561,"version":"4.5.0"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.phrs.2020.104730","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T11:19:49Z","timestamp":1582975189000},"page":"104730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":190,"special_numbering":"C","title":["Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives"],"prefix":"10.1016","volume":"155","author":[{"given":"Ramesh Kumar","family":"Saini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan R.R.","family":"Rengasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzi M.","family":"Mahomoodally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Soo","family":"Keum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.phrs.2020.104730_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/cancers8060058","article-title":"Tomato as a source of carotenoids and polyphenols targeted to cancer prevention","volume":"8","author":"Marti","year":"2016","journal-title":"Cancers"},{"issue":"Part 3","key":"10.1016\/j.phrs.2020.104730_bib0010","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.foodres.2015.07.047","article-title":"Carotenoids from fruits and vegetables: chemistry, analysis, occurrence, bioavailability and biological activities","volume":"76","author":"Saini","year":"2015","journal-title":"Food Res. Int."},{"issue":"2","key":"10.1016\/j.phrs.2020.104730_bib0015","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.abb.2006.09.012","article-title":"Lycopenoids: are lycopene metabolites bioactive?","volume":"458","author":"Lindshield","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.phrs.2020.104730_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600685","article-title":"Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans","volume":"61","author":"Bohn","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"11","key":"10.1016\/j.phrs.2020.104730_bib0025","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.nutres.2014.07.010","article-title":"Carotenoids, inflammation, and oxidative stress--implications of cellular signaling pathways and relation to chronic disease prevention","volume":"34","author":"Kaulmann","year":"2014","journal-title":"Nutr. Res."},{"issue":"100","key":"10.1016\/j.phrs.2020.104730_bib0030","doi-asserted-by":"crossref","first-page":"98498","DOI":"10.1039\/C6RA19639J","article-title":"DFT study on the quenching mechanism of singlet oxygen by lycopene","volume":"6","author":"Zhang","year":"2016","journal-title":"RSC Adv."},{"issue":"11","key":"10.1016\/j.phrs.2020.104730_bib0035","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1080\/10408398.2013.801827","article-title":"Lycopene and its antioxidant role in the prevention of cardiovascular diseases-A critical review","volume":"56","author":"Muller","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"3","key":"10.1016\/j.phrs.2020.104730_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/nu11030633","article-title":"Can lycopene impact the androgen Axis in prostate cancer?: a systematic review of cell culture and animal studies","volume":"11","author":"Applegate","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2020.104730_bib0045","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.biopha.2018.12.151","article-title":"A review for the pharmacological effect of lycopene in central nervous system disorders","volume":"111","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.phrs.2020.104730_bib0050","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/bph.13625","article-title":"Carotenoids: biochemistry, pharmacology and treatment","volume":"174","author":"Milani","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.phrs.2020.104730_bib0055","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1080\/10408398.2012.657809","article-title":"Tomato (Solanum lycopersicum) carotenoids and lycopenes chemistry; metabolism, absorption, nutrition, and allied health claims--a comprehensive review","volume":"55","author":"Perveen","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"2","key":"10.1016\/j.phrs.2020.104730_bib0060","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1017\/S0029665116000744","article-title":"Cardiovascular benefits of lycopene: fantasy or reality?","volume":"76","author":"Thies","year":"2017","journal-title":"Proc. Nutr. Soc."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.104730_bib0065","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1024\/0300-9831\/a000404","article-title":"A review about lycopene-induced nuclear hormone receptor signalling in inflammation and lipid metabolism via still unknown endogenous Apo-10\u00b4-Lycopenoids","volume":"86","author":"Caris-Veyrat","year":"2016","journal-title":"Int. J. Vitam. Nutr. Res."},{"issue":"6","key":"10.1016\/j.phrs.2020.104730_bib0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/antiox8060179","article-title":"Carotenoids and markers of oxidative stress in human observational studies and intervention trials: implications for chronic diseases","volume":"8","author":"Bohn","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.phrs.2020.104730_bib0075","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.tifs.2017.03.002","article-title":"Overview of carotenoid bioavailability determinants: from dietary factors to host genetic variations","volume":"69","author":"Desmarchelier","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.phrs.2020.104730_bib0080","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.fct.2018.07.060","article-title":"Antioxidant and pro-oxidant activities of carotenoids and their oxidation products","volume":"120","author":"Ribeiro","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.phrs.2020.104730_bib0085","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1079\/PHN2004598","article-title":"Plasma levels of six carotenoids in nine European countries: report from the European Prospective Investigation into Cancer and Nutrition (EPIC)","volume":"7","author":"Al-Delaimy","year":"2004","journal-title":"Public Health Nutr."},{"issue":"12","key":"10.1016\/j.phrs.2020.104730_bib0090","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1093\/jn\/133.12.4189","article-title":"[14C]-lycopene and [14C]-labeled polar products are differentially distributed in tissues of F344 rats prefed lycopene","volume":"133","author":"Zaripheh","year":"2003","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.phrs.2020.104730_bib0095","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.3390\/ijms15011433","article-title":"Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia","volume":"15","author":"Mariani","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2020.104730_bib0100","series-title":"Lycopene: Chemistry, Metabolism, and Bioavailability, Lycopene and Tomatoes in Human Nutrition and Health","first-page":"1","author":"Lowe","year":"2018"},{"issue":"3","key":"10.1016\/j.phrs.2020.104730_bib0105","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1104\/pp.111.182394","article-title":"Chemical quenching of singlet oxygen by carotenoids in plants","volume":"158","author":"Ramel","year":"2012","journal-title":"Plant Physiol."},{"key":"10.1016\/j.phrs.2020.104730_bib0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fct.2019.02.037","article-title":"Lutein derived from marigold (Tagetes erecta) petals triggers ROS generation and activates Bax and caspase-3 mediated apoptosis of human cervical carcinoma (HeLa) cells","volume":"127","author":"Gansukh","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.phrs.2020.104730_bib0115","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/antiox9010028","article-title":"Chemopreventive effect of \u03b2-cryptoxanthin on human cervical carcinoma (HeLa) cells is modulated through oxidative stress-induced apoptosis","volume":"9","author":"Gansukh","year":"2019","journal-title":"Antioxidants"},{"issue":"10","key":"10.1016\/j.phrs.2020.104730_bib0120","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1016\/j.bbagen.2013.05.032","article-title":"Astaxanthin inhibits NF-kappaB and Wnt\/beta-catenin signaling pathways via inactivation of Erk\/MAPK and PI3K\/Akt to induce intrinsic apoptosis in a hamster model of oral cancer","volume":"1830","author":"Kavitha","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2020.104730_bib0125","series-title":"NF-\u03baB Signaling Pathways in Carcinogenesis, Predictive Biomarkers in Oncology","first-page":"321","author":"Nakshatri","year":"2019"},{"issue":"20","key":"10.1016\/j.phrs.2020.104730_bib0130","doi-asserted-by":"crossref","first-page":"11304","DOI":"10.1021\/jf202433f","article-title":"Cancer chemopreventive effects of lycopene: suppression of MMP-7 expression and cell invasion in human colon cancer cells","volume":"59","author":"Lin","year":"2011","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.phrs.2020.104730_bib0135","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/cas.12349","article-title":"Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines","volume":"105","author":"Takeshima","year":"2014","journal-title":"Cancer Sci."},{"issue":"2","key":"10.1016\/j.phrs.2020.104730_bib0140","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/01635581.2011.523494","article-title":"Lycopene and apo-12\u2019-lycopenal reduce cell proliferation and alter cell cycle progression in human prostate cancer cells","volume":"63","author":"Ford","year":"2011","journal-title":"Nutr. Cancer"},{"issue":"10","key":"10.1016\/j.phrs.2020.104730_bib0145","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1158\/1541-7786.MCR-16-0075","article-title":"Mitochondrial beta-carotene 9\u2019,10\u2019 oxygenase modulates prostate cancer growth via NF-kappaB inhibition: a lycopene-independent function","volume":"14","author":"Gong","year":"2016","journal-title":"Mol. Cancer Res."},{"issue":"2","key":"10.1016\/j.phrs.2020.104730_bib0150","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/01635581.2012.643273","article-title":"Antimetastatic effects and mechanisms of apo-8\u2019-lycopenal, an enzymatic metabolite of lycopene, against human hepatocarcinoma SK-Hep-1 cells","volume":"64","author":"Yang","year":"2012","journal-title":"Nutr. Cancer"},{"issue":"6","key":"10.1016\/j.phrs.2020.104730_bib0155","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1093\/jn\/136.6.1552","article-title":"Apo-8\u2019-lycopenal and apo-12\u2019-lycopenal are metabolic products of lycopene in rat liver","volume":"136","author":"Gajic","year":"2006","journal-title":"J. Nutr."},{"issue":"28","key":"10.1016\/j.phrs.2020.104730_bib0160","doi-asserted-by":"crossref","first-page":"19327","DOI":"10.1074\/jbc.M512095200","article-title":"The biochemical characterization of ferret carotene-9\u2019,10\u2019-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo","volume":"281","author":"Hu","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"28","key":"10.1016\/j.phrs.2020.104730_bib0165","doi-asserted-by":"crossref","first-page":"14609","DOI":"10.1074\/jbc.M116.723684","article-title":"Substrate specificity of purified recombinant chicken \u03b2-carotene 9\u2032,10\u2032-oxygenase (BCO2)","volume":"291","author":"Dela Se\u00f1a","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2020.104730_bib0170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.redox.2012.10.001","article-title":"The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer","volume":"1","author":"Kansanen","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2020.104730_bib0175","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.redox.2017.04.013","article-title":"Controversy about pharmacological modulation of Nrf2 for cancer therapy","volume":"12","author":"Milkovic","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2020.104730_bib0180","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.2101","article-title":"Nrf2 in cancers: a double\u2010edged sword","author":"Wu","year":"2019","journal-title":"Cancer Med."},{"issue":"Pt. 1","key":"10.1016\/j.phrs.2020.104730_bib0185","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.fct.2017.09.050","article-title":"Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2\/NF-kappaB transcriptional pathway","volume":"109","author":"Zhao","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.phrs.2020.104730_bib0190","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/ijc.23696","article-title":"Enzymatic metabolites of lycopene induce Nrf2\u2010mediated expression of phase II detoxifying\/antioxidant enzymes in human bronchial epithelial cells","volume":"123","author":"Lian","year":"2008","journal-title":"Int. J. Cancer"},{"issue":"7","key":"10.1016\/j.phrs.2020.104730_bib0195","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1039\/C4FO00035H","article-title":"Chemomodulatory efficacy of lycopene on antioxidant enzymes and carcinogen-induced cutaneum carcinoma in mice","volume":"5","author":"Shen","year":"2014","journal-title":"Food Funct."},{"key":"10.1016\/j.phrs.2020.104730_bib0200","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jff.2018.06.002","article-title":"Lycopene-supplemented diet ameliorates cardiovascular remodeling and oxidative stress in rats with hypertension induced by Angiotensin II","volume":"47","author":"Ferreira-Santos","year":"2018","journal-title":"J. Funct. Food"},{"key":"10.1016\/j.phrs.2020.104730_bib0205","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jnutbio.2019.01.002","article-title":"Lycopene protects against pressure overload-induced cardiac hypertrophy by attenuating oxidative stress","volume":"66","author":"Zeng","year":"2019","journal-title":"J. Nutr. Biochem."},{"issue":"8","key":"10.1016\/j.phrs.2020.104730_bib0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136443","article-title":"Lycopene protects against hypoxia\/reoxygenation injury by alleviating ER stress induced apoptosis in neonatal mouse cardiomyocytes","volume":"10","author":"Xu","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.phrs.2020.104730_bib0215","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3892\/mmr.2014.2676","article-title":"Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodeling by inhibiting the nuclear factor-kappaB signaling pathway","volume":"11","author":"He","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.phrs.2020.104730_bib0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099070","article-title":"Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial","volume":"9","author":"Gajendragadkar","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.phrs.2020.104730_bib0225","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.abb.2010.06.031","article-title":"Lycopene in atherosclerosis prevention: an integrated scheme of the potential mechanisms of action from cell culture studies","volume":"504","author":"Palozza","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.phrs.2020.104730_bib0230","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4062\/biomolther.2015.085","article-title":"Pretreatment with lycopene attenuates oxidative stress-induced apoptosis in human mesenchymal stem cells","volume":"23","author":"Kim","year":"2015","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.phrs.2020.104730_bib0235","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.biopha.2017.11.116","article-title":"Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity","volume":"96","author":"Alvi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phrs.2020.104730_bib0240","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jff.2016.12.029","article-title":"Lycopene mitigates atrazine-induced cardiac inflammation via blocking the NF-\u03baB pathway and NO production","volume":"29","author":"Li","year":"2017","journal-title":"J. Funct. Food"},{"issue":"1","key":"10.1016\/j.phrs.2020.104730_bib0245","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10735-013-9535-2","article-title":"Protective effect of lycopene on cardiac function and myocardial fibrosis after acute myocardial infarction in rats via the modulation of p38 and MMP-9","volume":"45","author":"Wang","year":"2014","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.phrs.2020.104730_bib0250","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.fct.2016.09.016","article-title":"Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines","volume":"97","author":"Arathi","year":"2016","journal-title":"Food Chem. Toxicol."},{"issue":"8","key":"10.1016\/j.phrs.2020.104730_bib0255","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1080\/01635581.2015.1087040","article-title":"Lycopene enriched tomato extract inhibits hypoxia, angiogenesis, and metastatic markers in early stage N-nitrosodiethylamine induced hepatocellular carcinoma","volume":"67","author":"Bhatia","year":"2015","journal-title":"Nutr. Cancer"},{"issue":"5","key":"10.1016\/j.phrs.2020.104730_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062773","article-title":"Lycopene and beta-carotene induce growth inhibition and proapoptotic effects on ACTH-secreting pituitary adenoma cells","volume":"8","author":"Haddad","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.phrs.2020.104730_bib0265","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1017\/S0007114511005800","article-title":"Lycopene inhibits angiogenesis in human umbilical vein endothelial cells and rat aortic rings","volume":"108","author":"Elgass","year":"2012","journal-title":"Br. J. Nutr."},{"issue":"2","key":"10.1016\/j.phrs.2020.104730_bib0270","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.acthis.2011.03.004","article-title":"Effects of lycopene and apigenin on human umbilical vein endothelial cells in vitro under angiogenic stimulation","volume":"114","author":"Sahin","year":"2012","journal-title":"Acta Histochem."},{"key":"10.1016\/j.phrs.2020.104730_bib0275","series-title":"Antioxidant\/Pro-Oxidant Actions of Carotenoids, Carotenoids","first-page":"235","author":"Yeum","year":"2009"},{"issue":"7","key":"10.1016\/j.phrs.2020.104730_bib0280","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jnutbio.2005.01.009","article-title":"\u03b2-Carotene breakdown products may impair mitochondrial functions \u2014 potential side effects of high-dose \u03b2-carotene supplementation","volume":"16","author":"Siems","year":"2005","journal-title":"J. Nutr. Biochem."},{"issue":"12","key":"10.1016\/j.phrs.2020.104730_bib0285","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrc.2016.105","article-title":"Gap junctions and cancer: communicating for 50 years","volume":"16","author":"Aasen","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.phrs.2020.104730_bib0290","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jnutbio.2012.01.003","article-title":"Anti-angiogenic effects of lycopene through immunomodualtion of cytokine secretion in human peripheral blood mononuclear cells","volume":"24","author":"Huang","year":"2013","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.phrs.2020.104730_bib0295","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/mnfr.201100311","article-title":"Carotenoids and apocarotenoids in cellular signaling related to cancer: a review","volume":"56","author":"Sharoni","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"10.1016\/j.phrs.2020.104730_bib0300","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1158\/1940-6207.CAPR-15-0402","article-title":"Beta-carotene 9\u2019,10\u2019 oxygenase modulates the anticancer activity of dietary tomato or lycopene on prostate carcinogenesis in the TRAMP model","volume":"10","author":"Tan","year":"2017","journal-title":"Cancer Prev. Res. (Phila)"},{"issue":"8","key":"10.1016\/j.phrs.2020.104730_bib0305","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1073\/pnas.92.8.3439","article-title":"Prostate cancer in a transgenic mouse","volume":"92","author":"Greenberg","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"12","key":"10.1016\/j.phrs.2020.104730_bib0310","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1158\/1940-6207.CAPR-14-0182","article-title":"Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis","volume":"7","author":"Wan","year":"2014","journal-title":"Cancer Prev. Res. (Phila)"},{"key":"10.1016\/j.phrs.2020.104730_bib0315","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.neuropharm.2014.07.020","article-title":"Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats","volume":"86","author":"Yin","year":"2014","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.phrs.2020.104730_bib0320","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neurobiolaging.2013.06.020","article-title":"Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-alpha1\/heme oxygenase-1 pathways","volume":"35","author":"Lin","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phrs.2020.104730_bib0325","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejphar.2014.07.036","article-title":"Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in beta-amyloid induced Alzheimers disease","volume":"741","author":"Prakash","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2020.104730_bib0330","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neulet.2015.10.009","article-title":"Lycopene attenuates Abeta1-42 secretion and its toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease","volume":"608","author":"Chen","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2020.104730_bib0335","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2015.05.024","article-title":"Neuroprotective effect of lycopene against MPTP induced experimental Parkinson\u2019s disease in mice","volume":"599","author":"Prema","year":"2015","journal-title":"Neurosci. Lett."},{"issue":"50","key":"10.1016\/j.phrs.2020.104730_bib0340","doi-asserted-by":"crossref","first-page":"13173","DOI":"10.1021\/acs.jafc.8b05232","article-title":"The dose-response effect of lycopene on cerebral vessel and neuron impairment induced by hyperlipidemia","volume":"66","author":"Wang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2020.104730_bib0345","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jnutbio.2018.01.009","article-title":"Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress","volume":"56","author":"Wang","year":"2018","journal-title":"J. Nutr. Biochem."},{"issue":"7","key":"10.1016\/j.phrs.2020.104730_bib0350","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jnutbio.2015.01.012","article-title":"Lycopene abrogates Abeta(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer\u2019s disease","volume":"26","author":"Sachdeva","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phrs.2020.104730_bib0355","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neulet.2016.05.014","article-title":"Protective effect of lycopene on high-fat diet-induced cognitive impairment in rats","volume":"627","author":"Wang","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"10","key":"10.1016\/j.phrs.2020.104730_bib0360","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1194\/jlr.M300130-JLR200","article-title":"A physiological pharmacokinetic model describing the disposition of lycopene in healthy men","volume":"44","author":"Diwadkar-Navsariwala","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phrs.2020.104730_bib0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.05.082","article-title":"Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism","volume":"124","author":"Zhao","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.phrs.2020.104730_bib0370","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3945\/ajcn.115.118703","article-title":"Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression","volume":"103","author":"Graff","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.phrs.2020.104730_bib0375","first-page":"705","article-title":"Carotenoid intake and risk of colorectal adenomas in a cohort of male health professionals","volume":"24","author":"Jung","year":"2013","journal-title":"Cancer Causes Control"},{"issue":"2","key":"10.1016\/j.phrs.2020.104730_bib0380","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djt430","article-title":"Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era","volume":"106","author":"Zu","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"issue":"5","key":"10.1016\/j.phrs.2020.104730_bib0385","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3945\/an.114.005231","article-title":"Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors","volume":"5","author":"Burton-Freeman","year":"2014","journal-title":"Adv. Nutr."},{"issue":"3","key":"10.1016\/j.phrs.2020.104730_bib0390","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1017\/S0007114513002730","article-title":"Effects of lutein and lycopene on carotid intima-media thickness in Chinese subjects with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial","volume":"111","author":"Zou","year":"2014","journal-title":"Br. J. Nutr."},{"issue":"3\u20134","key":"10.1016\/j.phrs.2020.104730_bib0395","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000356486","article-title":"Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer\u2019s disease mortality in older adults","volume":"37","author":"Min","year":"2014","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"4","key":"10.1016\/j.phrs.2020.104730_bib0400","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.numecd.2014.12.008","article-title":"Dietary intake of carotenoids and risk of type 2 diabetes","volume":"25","author":"Sluijs","year":"2015","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.phrs.2020.104730_bib0405","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.semcancer.2016.06.002","article-title":"Food-based natural products for cancer management: is the whole greater than the sum of the parts?","volume":"40\u201341","author":"Hussain","year":"2016","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phrs.2020.104730_bib0410","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1038\/srep05031","article-title":"Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies","volume":"4","author":"Li","year":"2014","journal-title":"Sci. Rep."},{"issue":"24","key":"10.1016\/j.phrs.2020.104730_bib0415","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/jnci\/djs461","article-title":"Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies","volume":"104","author":"Eliassen","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"issue":"4","key":"10.1016\/j.phrs.2020.104730_bib0420","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/pcan.2017.25","article-title":"Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis","volume":"20","author":"Rowles","year":"2017","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"9","key":"10.1016\/j.phrs.2020.104730_bib0425","article-title":"Effect of carotene and lycopene on the risk of prostate cancer: a systematic review and dose-response meta-analysis of observational studies","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.phrs.2020.104730_bib0430","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1080\/01635581.2015.1075560","article-title":"A phase II randomized trial of lycopene-rich tomato extract among men with high-grade prostatic intraepithelial neoplasia","volume":"67","author":"Gann","year":"2015","journal-title":"Nutr. Cancer"},{"issue":"8","key":"10.1016\/j.phrs.2020.104730_bib0435","doi-asserted-by":"crossref","first-page":"2060S","DOI":"10.1093\/jn\/135.8.2060S","article-title":"Are there adverse effects of lycopene exposure?","volume":"135","author":"Trumbo","year":"2005","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.phrs.2020.104730_bib0440","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.yrtph.2006.05.007","article-title":"Risk assessment for the carotenoids lutein and lycopene","volume":"45","author":"Shao","year":"2006","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.104730_bib0445","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0273-2300(03)00013-8","article-title":"Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats","volume":"37","author":"Jonker","year":"2003","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"24","key":"10.1016\/j.phrs.2020.104730_bib0450","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/jnci\/djs461","article-title":"Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies","volume":"104","author":"Eliassen","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.phrs.2020.104730_bib0455","first-page":"1","article-title":"Use of lycopene as a food colour scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food","volume":"674","author":"Aguilar","year":"2008","journal-title":"Eur. Food Saf. Authority J."},{"issue":"43","key":"10.1016\/j.phrs.2020.104730_bib0460","doi-asserted-by":"crossref","first-page":"11362","DOI":"10.1021\/acs.jafc.8b04850","article-title":"Fractionation and characterization of lycopene-oxidation products by LC-MS\/MS (ESI)(+): elucidation of the chemopreventative potency of oxidized lycopene in breast-cancer cell lines","volume":"66","author":"Arathi","year":"2018","journal-title":"J. Agric. Food Chem."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661819323424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661819323424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:11:15Z","timestamp":1760911875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661819323424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":92,"alternative-id":["S1043661819323424"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104730","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104730"}}