{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:18:30Z","timestamp":1792595910863,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774151"],"award-info":[{"award-number":["81774151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81822047"],"award-info":[{"award-number":["81822047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81522051"],"award-info":[{"award-number":["81522051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.phrs.2020.104739","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T04:22:04Z","timestamp":1583122924000},"page":"104739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["A machine learning-driven study indicates emodin improves cardiac hypertrophy by modulation of mitochondrial SIRT3 signaling"],"prefix":"10.1016","volume":"155","author":[{"given":"Jian","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.phrs.2020.104739_bib0005","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.phrs.2020.104739_bib0010","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7326\/0003-4819-114-5-345","article-title":"Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension","volume":"114","author":"Koren","year":"1991","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.phrs.2020.104739_bib0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-3-319-55330-6_11","article-title":"Mitochondria and cardiac hypertrophy","volume":"982","author":"Facundo","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.phrs.2020.104739_bib0020","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrcardio.2016.203","article-title":"Expert consensus document: mitochondrial function as a therapeutic target in heart failure","volume":"14","author":"Brown","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"issue":"8\u20139","key":"10.1016\/j.phrs.2020.104739_bib0025","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.phymed.2009.10.009","article-title":"Microcalorimetric assay on the antimicrobial property of five hydroxyanthraquinone derivatives in rhubarb (Rheum palmatum L.) to Bifidobacterium adolescentis","volume":"17","author":"Wang","year":"2010","journal-title":"Phytomedicine"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.104739_bib0030","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0378-8741(00)00195-1","article-title":"Antifungal activity of anthraquinone derivatives from Rheum emodi","volume":"72","author":"Agarwal","year":"2000","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.104739_bib0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jep.2003.11.021","article-title":"Evaluation of Rhubarb using antioxidative activity as an index of pharmacological usefulness","volume":"91","author":"Iizuka","year":"2004","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.phrs.2020.104739_bib0040","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/ptr.2429","article-title":"Aqueous extract of rhubarb stabilizes vulnerable atherosclerotic plaques due to depression of inflammation and lipid accumulation","volume":"22","author":"Liu","year":"2008","journal-title":"Phytother. Res."},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2020.104739_bib0045","article-title":"Emodin attenuates pathological cardiac hypertrophy by regulating gene expression through acetyl-histone-mediated actions","volume":"3","author":"Evans","year":"2019","journal-title":"Curr. Dev. Nutr."},{"issue":"4","key":"10.1016\/j.phrs.2020.104739_bib0050","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.apsb.2019.04.003","article-title":"Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3","volume":"9","author":"Xiao","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2020.104739_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104315","article-title":"Aloe-emodin attenuates myocardial infarction and apoptosis via up-regulating miR-133 expression","volume":"146","author":"Yu","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2020.104739_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2018.06.029","article-title":"Rhein protects the myocardiac cells against hypoxia\/reoxygention-induced injury by suppressing GSK3beta activity","volume":"51","author":"Liu","year":"2018","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.phrs.2020.104739_bib0065","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.apsb.2018.10.008","article-title":"Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation","volume":"9","author":"Lu","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.phrs.2020.104739_bib0070","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/cbin.11146","article-title":"Chrysophanol attenuated isoproterenol-induced cardiac hypertrophy by inhibiting Janus kinase 2\/signal transducer and activator of transcription 3 signaling pathway","volume":"43","author":"Yuan","year":"2019","journal-title":"Cell Biol. Int."},{"issue":"D1","key":"10.1016\/j.phrs.2020.104739_bib0075","doi-asserted-by":"crossref","first-page":"D1110","DOI":"10.1093\/nar\/gky1021","article-title":"SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping","volume":"47","author":"Wu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2020.104739_bib0080","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.phrs.2015.11.015","article-title":"Drug-symptom networking: linking drug-likeness screening to drug discovery","volume":"103","author":"Xu","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.phrs.2020.104739_bib0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1056-8719(00)00107-6","article-title":"Drug-like properties and the causes of poor solubility and poor permeability","volume":"44","author":"Lipinski","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"D1","key":"10.1016\/j.phrs.2020.104739_bib0090","doi-asserted-by":"crossref","first-page":"D865","DOI":"10.1093\/nar\/gkw1039","article-title":"The human phenotype ontology in 2017","volume":"45","author":"Kohler","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"Database issue","key":"10.1016\/j.phrs.2020.104739_bib0095","doi-asserted-by":"crossref","first-page":"D36","DOI":"10.1093\/nar\/gku1055","article-title":"Gene: a gene-centered information resource at NCBI","volume":"43","author":"Brown","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.phrs.2020.104739_bib0100","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1021\/jm020406h","article-title":"Surflex: fully automatic flexible molecular docking using a molecular similarity-based search engine","volume":"46","author":"Jain","year":"2003","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2020.104739_bib0105","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/BF00124474","article-title":"Scoring noncovalent protein-ligand interactions: a continuous differentiable function tuned to compute binding affinities","volume":"10","author":"Jain","year":"1996","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"1","key":"10.1016\/j.phrs.2020.104739_bib0110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00894-002-0112-y","article-title":"Binding site characteristics in structure-based virtual screening: evaluation of current docking tools","volume":"9","author":"Schulz-Gasch","year":"2003","journal-title":"J. Mol. Model."},{"issue":"7","key":"10.1016\/j.phrs.2020.104739_bib0115","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/15548627.2015.1052208","article-title":"SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin","volume":"11","author":"Pi","year":"2015","journal-title":"Autophagy"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.104739_bib0120","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0014-5793(01)03228-8","article-title":"A study on permeability transition pore opening and cytochrome c release from mitochondria, induced by caspase-3 in vitro","volume":"510","author":"Xia","year":"2002","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.phrs.2020.104739_bib0125","first-page":"385","article-title":"Assay of mitochondrial functions by resazurin in vitro","volume":"25","author":"Zhang","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.104739_bib0130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.anireprosci.2010.05.005","article-title":"Alterations in mitochondrial function and spermatozoal motility in goat spermatozoa following incubation with a human lysozyme plasmid","volume":"121","author":"Ma","year":"2010","journal-title":"Anim. Reprod. Sci."},{"issue":"4","key":"10.1016\/j.phrs.2020.104739_bib0135","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.bbrc.2019.09.018","article-title":"TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction","volume":"519","author":"Ma","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.phrs.2020.104739_bib0140","first-page":"2758","article-title":"Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.phrs.2020.104739_bib0145","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1152\/physrev.00024.2010","article-title":"Myocardial AKT: the omnipresent nexus","volume":"91","author":"Sussman","year":"2011","journal-title":"Physiol. Rev."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.104739_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2011.04.010","article-title":"AMPK activation enhances PPARalpha activity to inhibit cardiac hypertrophy via ERK1\/2 MAPK signaling pathway","volume":"511","author":"Meng","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"issue":"Suppl. (1)","key":"10.1016\/j.phrs.2020.104739_bib0155","first-page":"S137","article-title":"Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis","volume":"153","author":"Sugden","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.104739_bib0160","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.phrs.2020.104739_bib0165","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","article-title":"Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators","volume":"127","author":"St-Pierre","year":"2006","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.phrs.2020.104739_bib0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011707","article-title":"A new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis","volume":"5","author":"Kong","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2020.104739_bib0175","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-3-319-41334-1_3","article-title":"Emodin and its role in chronic diseases","volume":"928","author":"Monisha","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2020.104739_bib0180","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1139\/cjpp-2015-0152","article-title":"Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3","volume":"94","author":"Koentges","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.104739_bib0185","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/cvr\/cvq250","article-title":"Mitochondrial SIRT3 and heart disease","volume":"88","author":"Pillai","year":"2010","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.phrs.2020.104739_bib0190","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCRESAHA.110.232306","article-title":"Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure","volume":"108","author":"Dai","year":"2011","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.phrs.2020.104739_bib0195","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/jmcc.2002.1526","article-title":"Role of oxidative stress in myocardial hypertrophy and failure","volume":"34","author":"Sawyer","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"11\u201312","key":"10.1016\/j.phrs.2020.104739_bib0200","article-title":"Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes","volume":"8","author":"Sugden","year":"2006","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.phrs.2020.104739_bib0205","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbrc.2019.07.029","article-title":"Dosing depending on SIRT3 activity attenuates doxorubicin-induced cardiotoxicity via elevated tolerance against mitochondrial dysfunction and oxidative stress","volume":"517","author":"Yang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2020.104739_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20120030","article-title":"SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging","volume":"444","author":"Giralt","year":"2012","journal-title":"Biochem. J."},{"issue":"14","key":"10.1016\/j.phrs.2020.104739_bib0215","doi-asserted-by":"crossref","first-page":"13560","DOI":"10.1074\/jbc.M414670200","article-title":"SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes","volume":"280","author":"Shi","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2020.104739_bib0220","doi-asserted-by":"crossref","first-page":"291","DOI":"10.7150\/ijbs.4.291","article-title":"SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression","volume":"4","author":"Jacobs","year":"2008","journal-title":"Int. J. Biol. Sci."},{"issue":"2\u20133","key":"10.1016\/j.phrs.2020.104739_bib0225","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0014-2999(03)01976-9","article-title":"Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9","volume":"473","author":"Srinivas","year":"2003","journal-title":"Eur. J. Pharmacol."},{"issue":"17\u201318","key":"10.1016\/j.phrs.2020.104739_bib0230","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.lfs.2007.08.040","article-title":"Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium","volume":"81","author":"Wu","year":"2007","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.phrs.2020.104739_bib0235","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1248\/bpb.34.1432","article-title":"Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes","volume":"34","author":"Ha","year":"2011","journal-title":"Biol. Pharm. Bull."},{"issue":"9","key":"10.1016\/j.phrs.2020.104739_bib0240","first-page":"15054","article-title":"Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1","volume":"8","author":"Qu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"4","key":"10.1016\/j.phrs.2020.104739_bib0245","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/jmcc.2002.1526","article-title":"Role of oxidative stress in myocardial hypertrophy and failure","volume":"34","author":"Sawyer","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"12","key":"10.1016\/j.phrs.2020.104739_bib0250","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1161\/01.RES.0000106132.04301.F5","article-title":"Ras, Akt, and mechanotransduction in the cardiac myocyte","volume":"93","author":"Sugden","year":"2003","journal-title":"Circ. Res."},{"issue":"44","key":"10.1016\/j.phrs.2020.104739_bib0255","doi-asserted-by":"crossref","first-page":"29730","DOI":"10.1074\/jbc.M805514200","article-title":"Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase","volume":"283","author":"Tan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2020.104739_bib0260","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1038\/ncomms7656","article-title":"Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3","volume":"6","author":"Pillai","year":"2015","journal-title":"Nat. Commun."},{"issue":"6904","key":"10.1016\/j.phrs.2020.104739_bib0265","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature01036","article-title":"Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress","volume":"419","author":"Kops","year":"2002","journal-title":"Nature"},{"issue":"5564","key":"10.1016\/j.phrs.2020.104739_bib0270","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1126\/science.1069004","article-title":"Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway","volume":"295","author":"Nemoto","year":"2002","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.phrs.2020.104739_bib0275","doi-asserted-by":"crossref","first-page":"254","DOI":"10.7150\/ijbs.17053","article-title":"Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1a-SOD2-mediated regulation of mitochondrial function","volume":"13","author":"Ding","year":"2017","journal-title":"Int. J. Biol. Sci."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182030267X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182030267X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:32:00Z","timestamp":1778581920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366182030267X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":55,"alternative-id":["S104366182030267X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104739","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A machine learning-driven study indicates emodin improves cardiac hypertrophy by modulation of mitochondrial SIRT3 signaling","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104739","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104739"}}