{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:22:32Z","timestamp":1782300152235,"version":"3.54.5"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974083"],"award-info":[{"award-number":["81974083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330074"],"award-info":[{"award-number":["81330074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81620108029"],"award-info":[{"award-number":["81620108029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81261160507"],"award-info":[{"award-number":["81261160507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170632"],"award-info":[{"award-number":["81170632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873597"],"award-info":[{"award-number":["81873597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7172113"],"award-info":[{"award-number":["7172113"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.phrs.2020.104751","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T12:05:06Z","timestamp":1583496306000},"page":"104751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis"],"prefix":"10.1016","volume":"155","author":[{"given":"Jinzhao","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10174","key":"10.1016\/j.phrs.2020.104751_bib0005","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(18)32782-X","article-title":"Autosomal dominant polycystic kidney disease","volume":"393","author":"Cornec-Le Gall","year":"2019","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.phrs.2020.104751_bib0010","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1681\/ASN.2018050493","article-title":"Prevalence estimates of polycystic kidney and liver disease by population sequencing","volume":"29","author":"Lanktree","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"9981","key":"10.1016\/j.phrs.2020.104751_bib0015","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0140-6736(15)60907-2","article-title":"Autosomal dominant polycystic kidney disease: the changing face of clinical management","volume":"385","author":"Ong","year":"2015","journal-title":"Lancet"},{"issue":"9569","key":"10.1016\/j.phrs.2020.104751_bib0020","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/path.2734","article-title":"Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease","volume":"222","author":"Hassane","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.phrs.2020.104751_bib0030","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/978-3-319-51436-9_12","article-title":"Inflammation and fibrosis in polycystic kidney disease","volume":"60","author":"Song","year":"2017","journal-title":"Results Probl. Cell Differ."},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0035","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1681\/ASN.2013040398","article-title":"Strategies targeting cAMP signaling in the treatment of polycystic kidney disease","volume":"25","author":"Torres","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"issue":"8","key":"10.1016\/j.phrs.2020.104751_bib0040","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrneph.2014.104","article-title":"Renal transplantation in autosomal dominant polycystic kidney disease","volume":"10","author":"Kanaan","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"issue":"20","key":"10.1016\/j.phrs.2020.104751_bib0045","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1056\/NEJMe1714276","article-title":"Tolvaptan and autosomal dominant polycystic kidney disease","volume":"377","author":"Ingelfinger","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2020.104751_bib0050","doi-asserted-by":"crossref","DOI":"10.1038\/nrneph.2017.180","article-title":"Polycystic kidney disease: tolvaptan slows disease progression in late-stage ADPKD","author":"Ong","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"issue":"20","key":"10.1016\/j.phrs.2020.104751_bib0055","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1056\/NEJMoa1710030","article-title":"Tolvaptan in later-stage autosomal dominant polycystic kidney disease","volume":"377","author":"Torres","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"27","key":"10.1016\/j.phrs.2020.104751_bib0060","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1073\/pnas.1620454114","article-title":"Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease","volume":"114","author":"Ciolek","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0065","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejphar.2010.12.008","article-title":"Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathways","volume":"654","author":"Gao","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.phrs.2020.104751_bib0070","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1681\/ASN.2008030259","article-title":"Triptolide reduces cystogenesis in a model of ADPKD","volume":"19","author":"Leuenroth","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.phrs.2020.104751_bib0075","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.kint.2017.04.013","article-title":"Ganoderma triterpenes retard renal cyst development by downregulating Ras\/MAPK signaling and promoting cell differentiation","volume":"92","author":"Su","year":"2017","journal-title":"Kidney Int."},{"issue":"10","key":"10.1016\/j.phrs.2020.104751_bib0080","doi-asserted-by":"crossref","first-page":"F1234","DOI":"10.1152\/ajprenal.00356.2011","article-title":"Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models","volume":"302","author":"Zhou","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"6","key":"10.1016\/j.phrs.2020.104751_bib0085","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1172\/JCI72272","article-title":"Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease","volume":"124","author":"Harris","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.phrs.2020.104751_bib0090","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nrneph.2017.127","article-title":"New treatment paradigms for ADPKD: moving towards precision medicine","volume":"13","author":"Lanktree","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"issue":"8","key":"10.1016\/j.phrs.2020.104751_bib0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073173","article-title":"The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney disease","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.phrs.2020.104751_bib0100","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1096\/fj.201801338RRR","article-title":"Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease","volume":"33","author":"Wang","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.phrs.2020.104751_bib0105","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.addr.2017.12.019","article-title":"Targeting renal fibrosis: mechanisms and drug delivery systems","volume":"129","author":"Nastase","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.phrs.2020.104751_bib0110","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1096\/fj.201800563RR","article-title":"Impact of miR-192 and miR-194 on cyst enlargement through EMT in autosomal dominant polycystic kidney disease","volume":"33","author":"Kim","year":"2019","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.phrs.2020.104751_bib0115","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95874","article-title":"Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD","volume":"3","author":"Li","year":"2018","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00109-017-1606-5","article-title":"beta-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1\/beta-catenin signaling in mice","volume":"96","author":"Xu","year":"2018","journal-title":"J. Mol. Med."},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ydbio.2012.01.014","article-title":"A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development","volume":"364","author":"Gallegos","year":"2012","journal-title":"Dev. Biol. (Basel)"},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0130","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.tcb.2018.08.005","article-title":"WNT signaling in Cancer immunosurveillance","volume":"29","author":"Galluzzi","year":"2019","journal-title":"Trends Cell Biol."},{"issue":"9","key":"10.1016\/j.phrs.2020.104751_bib0135","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrneph.2015.46","article-title":"The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease","volume":"11","author":"Seeger-Nukpezah","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phrs.2020.104751_bib0140","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.phrs.2019.01.039","article-title":"Targeting ERK1\/2 protein-serine\/threonine kinases in human cancers","volume":"142","author":"Roskoski","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"2S Suppl 1","key":"10.1016\/j.phrs.2020.104751_bib0145","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1097\/TP.0000000000001729","article-title":"mTOR inhibition and kidney diseases","volume":"102","author":"Ma","year":"2018","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0150","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12943-018-0935-5","article-title":"Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1\/mTOR pathway","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol. Cancer"},{"issue":"4","key":"10.1016\/j.phrs.2020.104751_bib0155","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-beta signaling in immunity and Cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.phrs.2020.104751_bib0160","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tips.2019.03.002","article-title":"Triptolide and its derivatives as Cancer therapies","volume":"40","author":"Noel","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"issue":"11","key":"10.1016\/j.phrs.2020.104751_bib0165","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1073\/pnas.0700499104","article-title":"Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease","volume":"104","author":"Leuenroth","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.phrs.2020.104751_bib0170","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jfda.2019.07.001","article-title":"Quercetin facilitates cell death and chemosensitivity through RAGE\/PI3K\/AKT\/mTOR axis in human pancreatic cancer cells","volume":"27","author":"Lan","year":"2019","journal-title":"J. Food Drug Anal."},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0175","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1039\/C7FO01253E","article-title":"Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model","volume":"9","author":"Zhu","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.phrs.2020.104751_bib0180","article-title":"Ketogenic diet in the treatment of cancer - Where do we stand?","author":"Weber","year":"2019","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phrs.2020.104751_bib0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2019.09.012","article-title":"Ketosis ameliorates renal cyst growth in polycystic kidney disease","author":"Torres","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2020.104751_bib0190","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.phrs.2017.12.034","article-title":"Targeting oncogenic transcription factors by polyphenols: a novel approach for cancer therapy","volume":"130","author":"Rajagopal","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2020.104751_bib0195","article-title":"Cardamonin, a natural chalcone, reduces 5-fluorouracil resistance of gastric cancer cells through targeting Wnt\/beta-catenin signal pathway","author":"Hou","year":"2019","journal-title":"Invest. New Drugs"},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0200","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1038\/s41598-017-14253-8","article-title":"Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression","volume":"7","author":"James","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2020.104751_bib0205","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/cdd.2014.145","article-title":"Beta-Catenin and NF-kappaB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer","volume":"22","author":"Jia","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2020.104751_bib0210","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bcp.2018.07.039","article-title":"Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR\/Nrf2\/NQO1 pathway","volume":"155","author":"Wang","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"16","key":"10.1016\/j.phrs.2020.104751_bib0215","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1055\/a-0626-7426","article-title":"Anti-inflammatory effects of Cardamonin in ovarian Cancer cells are mediated via mTOR suppression","volume":"84","author":"Chen","year":"2018","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.phrs.2020.104751_bib0220","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s10495-016-1313-7","article-title":"Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer","volume":"22","author":"Zhang","year":"2017","journal-title":"Apoptosis"},{"issue":"12","key":"10.1016\/j.phrs.2020.104751_bib0225","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1016\/j.bmcl.2015.04.054","article-title":"Cardamonin induces autophagy and an antiproliferative effect through JNK activation in human colorectal carcinoma HCT116 cells","volume":"25","author":"Kim","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.phrs.2020.104751_bib0230","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4062\/biomolther.2014.117","article-title":"Cardamonin suppresses TGF-beta1-Induced epithelial mesenchymal transition via restoring protein phosphatase 2A expression","volume":"23","author":"Kim","year":"2015","journal-title":"Biomol. Ther. (Seoul)"},{"issue":"2","key":"10.1016\/j.phrs.2020.104751_bib0235","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/biof.1315","article-title":"Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt\/beta-catenin signaling cascades and reversal of epithelial-mesenchymal transition","volume":"43","author":"Shrivastava","year":"2017","journal-title":"Biofactors"},{"issue":"9","key":"10.1016\/j.phrs.2020.104751_bib0240","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1681\/ASN.2016111235","article-title":"Integrin-linked kinase signaling promotes cyst growth and fibrosis in polycystic kidney disease","volume":"28","author":"Raman","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.phrs.2020.104751_bib0245","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1172\/JCI90921","article-title":"Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease","volume":"127","author":"Li","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.phrs.2020.104751_bib0250","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1681\/ASN.2015030287","article-title":"Inhibition of activin signaling slows progression of polycystic kidney disease","volume":"27","author":"Leonhard","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2020.104751_bib0255","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bcp.2018.05.005","article-title":"Lansoprazole reduces renal cyst in polycystic kidney disease via inhibition of cell proliferation and fluid secretion","volume":"154","author":"Nantavishit","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.104751_bib0260","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/j.2040-4603.2017.tb00760.x","article-title":"Polycystic kidney disease","volume":"7","author":"Ghata","year":"2017","journal-title":"Compr. Physiol."},{"issue":"3","key":"10.1016\/j.phrs.2020.104751_bib0265","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1681\/ASN.2013030209","article-title":"Hypoxia-inducible factor-1alpha causes renal cyst expansion through calcium-activated chloride secretion","volume":"25","author":"Buchholz","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.phrs.2020.104751_bib0270","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.kint.2018.06.008","article-title":"HIF-1alpha promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease","volume":"94","author":"Kraus","year":"2018","journal-title":"Kidney Int."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820303479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820303479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:14:30Z","timestamp":1760912070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661820303479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":54,"alternative-id":["S1043661820303479"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104751","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104751","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104751"}}