{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:16:57Z","timestamp":1784254617555,"version":"3.55.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012397","name":"Army Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.phrs.2020.104780","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T02:11:22Z","timestamp":1588299082000},"page":"104780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Rottlerin acts as a therapeutic in primary open-angle glaucoma by targeting the trabecular meshwork via activation of Rap1 signaling"],"prefix":"10.1016","volume":"159","author":[{"given":"Jingyi","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiumei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongdi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.phrs.2020.104780_bib0005","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of Glaucoma and projections of Glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.phrs.2020.104780_bib0010","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/bjo.86.2.238","article-title":"The definition and classification of glaucoma in prevalence surveys","volume":"86","author":"Foster","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.phrs.2020.104780_bib0015","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","article-title":"Primary open-angle glaucoma","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"9422","key":"10.1016\/j.phrs.2020.104780_bib0020","first-page":"1711","article-title":"Primary open-angle glaucoma","volume":"363","author":"Kwon","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.phrs.2020.104780_bib0025","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1167\/iovs.03-0077","article-title":"Risk factors associated with the incidence of open-angle glaucoma: the visual impairment project","volume":"44","author":"Anhchuong","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2020.104780_bib0030","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch. Ophthalmol."},{"issue":"3","key":"10.1016\/j.phrs.2020.104780_bib0035","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0014-4835(71)90149-7","article-title":"Uveoscleral drainage of aqueous humour in human eyes","volume":"12","author":"Bill","year":"1971","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.phrs.2020.104780_bib0040","series-title":"Morphology of Aqueous Outflow Pathways in Normal and Glaucomatous Eyes","author":"Rohen","year":"1989"},{"issue":"6","key":"10.1016\/j.phrs.2020.104780_bib0045","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1006\/exer.1993.1085","article-title":"Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG)","volume":"56","author":"Rohen","year":"1993","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.phrs.2020.104780_bib0050","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0039-6257(96)80066-X","article-title":"The extracellular matrix and its modulation in the trabecular meshwork","volume":"40","author":"Weinreb","year":"1996","journal-title":"Surv. Ophthalmol."},{"issue":"4","key":"10.1016\/j.phrs.2020.104780_bib0055","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.exer.2008.11.025","article-title":"Structural changes of the trabecular meshwork in different kinds of glaucoma","volume":"88","author":"Tektas","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.phrs.2020.104780_bib0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.exer.2016.07.011","article-title":"Trabecular meshwork stiffness in glaucoma","volume":"158","author":"Wang","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.phrs.2020.104780_bib0065","first-page":"1513","article-title":"Apoptosis in the trabecular meshwork of glaucomatous patients","volume":"14","author":"Baleriola","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.phrs.2020.104780_bib0070","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.preteyeres.2017.02.001","article-title":"Characterizing the \"POAGome\": a bioinformatics-driven approach to primary open-angle glaucoma","volume":"58","author":"ID","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.phrs.2020.104780_bib0075","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nrc2044","article-title":"The Connectivity Map: a new tool for biomedical research","volume":"7","author":"Lamb","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"5795","key":"10.1016\/j.phrs.2020.104780_bib0080","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2020.104780_bib0085","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/bbrc.1994.1199","article-title":"Rottlerin, a novel protein kinase inhibitor","volume":"199","author":"Gschwendt","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2020.104780_bib0090","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/350826","article-title":"Rottlerin and cancer: novel evidence and mechanisms","volume":"2012","author":"Maioli","year":"2012","journal-title":"Sci. World. J."},{"issue":"1","key":"10.1016\/j.phrs.2020.104780_bib0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-213X-1-3","article-title":"The mouse anterior chamber angle and trabecular meshwork develop without cell death","volume":"1","author":"Smith","year":"2001","journal-title":"BMC Dev. Biol."},{"issue":"6","key":"10.1016\/j.phrs.2020.104780_bib0100","first-page":"2561","article-title":"Contractile markers distinguish structures of the mouse aqueous drainage tract","volume":"19","author":"Ko","year":"2013","journal-title":"Mol. Vis."},{"issue":"9","key":"10.1016\/j.phrs.2020.104780_bib0105","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1167\/iovs.13-12128","article-title":"Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma","volume":"54","author":"Liu","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.phrs.2020.104780_bib0110","series-title":"Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments","author":"Smyth","year":"2004"},{"key":"10.1016\/j.phrs.2020.104780_bib0115","series-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor","first-page":"397","article-title":"Limma: linear models for microarray data","author":"Smyth","year":"2005"},{"issue":"14","key":"10.1016\/j.phrs.2020.104780_bib0120","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","article-title":"GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor","volume":"23","author":"Sean","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phrs.2020.104780_bib0125","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkm415","article-title":"Lempicki RA. DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists","volume":"35","author":"Huang","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.phrs.2020.104780_bib0130","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"issue":"11","key":"10.1016\/j.phrs.2020.104780_bib0135","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"D1","key":"10.1016\/j.phrs.2020.104780_bib0140","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.phrs.2020.104780_bib0145","doi-asserted-by":"crossref","first-page":"W32","DOI":"10.1093\/nar\/gku293","article-title":"Swiss Target Prediction: a web server for target prediction of bioactive small molecules","volume":"42","author":"Daina","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.phrs.2020.104780_bib0150","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1073\/pnas.76.9.4498","article-title":"Fluorescent phallotoxin, a tool for the visualization of cellular actin","volume":"76","author":"Wulf","year":"1979","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"7","key":"10.1016\/j.phrs.2020.104780_bib0155","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"issue":"Pt A","key":"10.1016\/j.phrs.2020.104780_bib0160","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mito.2014.09.002","article-title":"ATP\/ADP ratio, the missed connection between mitochondria and the Warburg effect","volume":"19","author":"Maldonado","year":"2014","journal-title":"Mitochondrion."},{"key":"10.1016\/j.phrs.2020.104780_bib0165","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1101\/sqb.2011.76.010868","article-title":"Control of glycolysis through regulation of PFK1: old friends and recent additions","volume":"76","author":"Mor","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"issue":"8","key":"10.1016\/j.phrs.2020.104780_bib0170","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0002-9343(03)00114-1","article-title":"Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients","volume":"114","author":"Izzotti","year":"2003","journal-title":"Am. J. Med."},{"issue":"11","key":"10.1016\/j.phrs.2020.104780_bib0175","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1167\/iovs.09-3871","article-title":"Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma","volume":"50","author":"Izzotti","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"13","key":"10.1016\/j.phrs.2020.104780_bib0180","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1167\/iovs.13-12494","article-title":"Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells","volume":"54","author":"Wallace","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2020.104780_bib0185","doi-asserted-by":"crossref","first-page":"BIO106","DOI":"10.1167\/iovs.17-21723","article-title":"Functional activity of matrix metalloproteinases 2 and 9 in tears of patients with Glaucoma","volume":"58","author":"Sahay","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.phrs.2020.104780_bib0190","series-title":"The Dysfunction of the Trabecular Meshwork During Glaucoma Course","author":"Sacc\u00e0","year":"2015"},{"issue":"3","key":"10.1016\/j.phrs.2020.104780_bib0195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00061198-199506000-00007","article-title":"Cytoskeletal changes in cultured human glaucoma trabecular meshwork cells","volume":"4","author":"Clark","year":"1995","journal-title":"J. Glaucoma"},{"issue":"1","key":"10.1016\/j.phrs.2020.104780_bib0200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1242\/jcs.03306","article-title":"Rap1: a key regulator in cell-cell junction formation","volume":"120","author":"Kooistra","year":"2007","journal-title":"J. Cell. Sci."},{"issue":"5558","key":"10.1016\/j.phrs.2020.104780_bib0205","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1126\/science.1067549","article-title":"Rap1 GTPase regulation of adherens junction positioning and cell adhesion","volume":"295","author":"Knox","year":"2002","journal-title":"Science"},{"issue":"Pt 1","key":"10.1016\/j.phrs.2020.104780_bib0210","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/bj2890017","article-title":"Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins","volume":"289","author":"Bokoch","year":"1993","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.phrs.2020.104780_bib0215","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1091\/mbc.e09-03-0177","article-title":"A Rap\/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected]","volume":"21","author":"Kortholt","year":"2010","journal-title":"Mol. Biol. Cell"},{"issue":"414","key":"10.1016\/j.phrs.2020.104780_bib0220","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaf4259","article-title":"Rewarded with active Rap1","volume":"9","author":"Gough","year":"2016","journal-title":"Sci. Signal."},{"issue":"10","key":"10.1016\/j.phrs.2020.104780_bib0225","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1167\/iovs.06-0299","article-title":"Variations in primary open-angle Glaucoma prevalence by age, gender, and race: a bayesian meta-analysis","volume":"47","author":"Rudnicka","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.phrs.2020.104780_bib0230","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0161-6420(01)00654-6","article-title":"Evidence for genetic heterogeneity within eight glaucoma families, with the GLC1A Gln368STOP mutation being an important phenotypic modifier","volume":"108","author":"Craig","year":"2001","journal-title":"Ophthalmology."},{"issue":"3","key":"10.1016\/j.phrs.2020.104780_bib0235","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/09286589409047221","article-title":"Genetic risk factor in primary open-angle glaucoma: a case-control study","volume":"1","author":"Charliat","year":"1994","journal-title":"Ophthalmic Epidemiol."},{"issue":"2","key":"10.1016\/j.phrs.2020.104780_bib0240","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2015.09.012","article-title":"Verteporfin without light stimulation inhibits YAP activation in trabecular meshwork cells: implications for glaucoma treatment","volume":"466","author":"Chen","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.phrs.2020.104780_bib0245","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00061198-200008000-00009","article-title":"Effect of calcium channel blockers alone and in combination with antiglaucoma medications on intraocular pressure in the primate eye","volume":"9","author":"Siegner","year":"2000","journal-title":"J. Glaucoma"},{"issue":"4","key":"10.1016\/j.phrs.2020.104780_bib0250","first-page":"325","article-title":"Ouabain and Aqueous Humor Dynamics in the Rabbit Eye","volume":"2","author":"BECKER","year":"1963","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"41","key":"10.1016\/j.phrs.2020.104780_bib0255","doi-asserted-by":"crossref","first-page":"37986","DOI":"10.1074\/jbc.M105073200","article-title":"Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation","volume":"276","author":"Soltoff","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2020.104780_bib0260","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1124\/jpet.106.108621","article-title":"Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells","volume":"319","author":"Jane","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"9","key":"10.1016\/j.phrs.2020.104780_bib0265","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.bcp.2012.08.007","article-title":"Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K\/Akt\/mTOR pathway in human pancreatic cancer stem cells","volume":"84","author":"Singh","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.104780_bib0270","first-page":"327","article-title":"Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells","volume":"8","author":"Parmer","year":"1997","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.phrs.2020.104780_bib0275","article-title":"Alternative pathways of Cancer cell death by rottlerin: apoptosis versus autophagy","volume":"2012","author":"Torricelli","year":"2012","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"3","key":"10.1016\/j.phrs.2020.104780_bib0280","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/emboj\/18.3.605","article-title":"The Rap1 GTPase functions as a regulator of morphogenesis in vivo","volume":"18","author":"Asha","year":"1999","journal-title":"EMBO J."},{"issue":"19","key":"10.1016\/j.phrs.2020.104780_bib0285","doi-asserted-by":"crossref","first-page":"E3839","DOI":"10.1073\/pnas.1608769114","article-title":"Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective","volume":"114","author":"Harder","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.phrs.2020.104780_bib0290","series-title":"Brain-derived Neurotrophic Factor Activates ERK5 in Cortical Neurons Via a Rap1-MEKK2 Signaling Cascade","author":"Wang","year":"2006"},{"issue":"2","key":"10.1016\/j.phrs.2020.104780_bib0295","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ydbio.2016.08.026","article-title":"The axon guidance function of Rap1 small GTPase is independent of PlexA RasGAP activity in Drosophila","volume":"418","author":"Yang","year":"2016","journal-title":"Dev. Biol."},{"issue":"6","key":"10.1016\/j.phrs.2020.104780_bib0300","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1530\/ERC-10-0224","article-title":"Protein kinase C\u03b4 inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors","volume":"18","author":"Chen","year":"2011","journal-title":"Endocr. Relat. Cancer"},{"issue":"9","key":"10.1016\/j.phrs.2020.104780_bib0305","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.tips.2007.07.003","article-title":"Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta","volume":"28","author":"Soltoff","year":"2007","journal-title":"Trends Pharmacol. Sci."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661819318985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661819318985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:08:30Z","timestamp":1760911710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661819318985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":61,"alternative-id":["S1043661819318985"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104780","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rottlerin acts as a therapeutic in primary open-angle glaucoma by targeting the trabecular meshwork via activation of Rap1 signaling","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104780","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104780"}}