{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:36:36Z","timestamp":1789061796086,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.phrs.2020.104936","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T11:39:20Z","timestamp":1590493160000},"page":"104936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Fecal bacteria can predict the efficacy of rifaximin in patients with diarrhea-predominant irritable bowel syndrome"],"prefix":"10.1016","volume":"159","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaichao","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhua","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 2","key":"10.1016\/j.phrs.2020.104936_bib0005","first-page":"II43","article-title":"Functional bowel disorders and functional abdominal pain","volume":"45","author":"Thompson","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2020.104936_bib0010","doi-asserted-by":"crossref","first-page":"ITC81","DOI":"10.7326\/AITC201706060","article-title":"Irritable bowel syndrome","volume":"166","author":"Sultan","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.phrs.2020.104936_bib0015","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2147\/JIR.S174982","article-title":"The role of inflammation in irritable bowel syndrome (IBS)","volume":"11","author":"Ng","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.phrs.2020.104936_bib0020","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2982.2012.01891.x","article-title":"Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome","volume":"24","author":"Carroll","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.phrs.2020.104936_bib0025","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.14592.1","article-title":"The gut microbiome and irritable bowel syndrome","volume":"7","author":"Menees","year":"2018","journal-title":"F1000Res"},{"issue":"Suppl. 1","key":"10.1016\/j.phrs.2020.104936_bib0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/apt.13434","article-title":"Review article: the antimicrobial effects of rifaximin on the gut microbiota","volume":"43","author":"DuPont","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2020.104936_bib0035","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tax025","article-title":"A meta-analysis of the use of rifaximin to prevent travellers\u2019 diarrhoea","volume":"24","author":"Ng","year":"2017","journal-title":"J. Travel Med."},{"key":"10.1016\/j.phrs.2020.104936_bib0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.anaerobe.2018.10.011","article-title":"A systematic review of the use of rifaximin for Clostridium difficile infections","volume":"55","author":"Ng","year":"2019","journal-title":"Anaerobe"},{"key":"10.1016\/j.phrs.2020.104936_bib0045","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1038\/ctg.2016.32","article-title":"Effects of Rifaximin on transit, permeability, fecal microbiome, and organic acid excretion in irritable bowel syndrome","volume":"7","author":"Acosta","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.phrs.2020.104936_bib0050","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJMoa1004409","article-title":"Rifaximin therapy for patients with irritable bowel syndrome without constipation","volume":"364","author":"Mark Pimentel","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2020.104936_bib0055","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1053\/j.gastro.2016.08.003","article-title":"Repeat treatment with rifaximin is safe and effective in patients with diarrhea-predominant irritable bowel syndrome","volume":"151","author":"Lembo","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2020.104936_bib0060","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/19490976.2016.1215805","article-title":"Limited prolonged effects of rifaximin treatment on irritable bowel syndrome-related differences in the fecal microbiome and metabolome","volume":"7","author":"Zeber-Lubecka","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2020.104936_bib0065","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1053\/j.gastro.2016.09.049","article-title":"Identification of an intestinal microbiota signature associated with severity of irritable bowel syndrome","volume":"152","author":"Tap","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2020.104936_bib0070","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1053\/j.gastro.2017.06.004","article-title":"Intestinal fungal dysbiosis is associated with visceral hypersensitivity in patients with irritable bowel syndrome and rats","volume":"153","author":"Botschuijver","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2020.104936_bib0075","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2020.104936_bib0080","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/gut.2005.075127","article-title":"Use and abuse of hydrogen breath tests","volume":"55","author":"Simren","year":"2006","journal-title":"Gut"},{"issue":"Suppl. 1","key":"10.1016\/j.phrs.2020.104936_bib0085","first-page":"1","article-title":"Methodology and indications of H2-breath testing in gastrointestinal diseases: the Rome Consensus Conference","volume":"29","author":"Gasbarrini","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2020.104936_bib0090","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of highthroughput community sequencing data","volume":"7","author":"Gregory caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phrs.2020.104936_bib0095","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phrs.2020.104936_bib0100","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/molbev\/msp077","article-title":"FastTree: computing large minimum evolution trees with profiles instead of a distance matrix","volume":"26","author":"Price","year":"2009","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.phrs.2020.104936_bib0105","doi-asserted-by":"crossref","first-page":"e2584","DOI":"10.7717\/peerj.2584","article-title":"VSEARCH: a versatile open source tool for metagenomics","volume":"4","author":"Rognes","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.phrs.2020.104936_bib0110","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1111\/mec.12481","article-title":"Towards a unified paradigm for sequence-based identification of fungi","volume":"22","author":"K\u00f5ljalg","year":"2013","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.phrs.2020.104936_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3852\/14-293","article-title":"Fungal identification using a Bayesian classifier and the Warcup training set of internal transcribed spacer sequences","volume":"108","author":"Deshpande","year":"2016","journal-title":"Mycologia"},{"key":"10.1016\/j.phrs.2020.104936_bib0120","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.phrs.2020.104936_bib0125","doi-asserted-by":"crossref","first-page":"e1029","DOI":"10.7717\/peerj.1029","article-title":"Compact graphical representation of phylogenetic data and metadata with GraPhlAn","volume":"3","author":"Asnicar","year":"2015","journal-title":"PeerJ"},{"key":"10.1016\/j.phrs.2020.104936_bib0130","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phrs.2020.104936_bib0135","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","article-title":"STAMP: statistical analysis of taxonomic and functional profiles","volume":"30","author":"Parks","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phrs.2020.104936_bib0140","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chom.2014.02.005","article-title":"The treatment-naive microbiome in new-onset Crohn\u2019s disease","volume":"15","author":"Gevers","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phrs.2020.104936_bib0145","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1574-6968.2004.tb09564.x","article-title":"Acquired resistance to bile increases fructose-6-phosphate phosphoketolase activity in Bifidobacterium","volume":"235","author":"Sanchez","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.phrs.2020.104936_bib0150","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/j.gastro.2019.03.049","article-title":"Gut microbiota in patients with irritable bowel Syndrome-A systematic review","volume":"157","author":"Pittayanon","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2020.104936_bib0155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40168-017-0260-z","article-title":"Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome","volume":"5","author":"Labus","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.phrs.2020.104936_bib0160","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1136\/gutjnl-2011-301501","article-title":"An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota","volume":"61","author":"Jeffery","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2020.104936_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mib.2017.07.003","article-title":"Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction","volume":"39","author":"Litvak","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.phrs.2020.104936_bib0170","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.phrs.2020.104936_bib0175","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00002-19","article-title":"Enterobacter spp.: update on taxonomy, clinical aspects, and emerging antimicrobial resistance","volume":"32","author":"Davin-Regli","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.phrs.2020.104936_bib0180","article-title":"Evaluation of Escherichia coli pathotypes associated with irritable bowel syndrome","volume":"365","author":"Dogan","year":"2018","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.phrs.2020.104936_bib0185","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41429-017-0022-y","article-title":"Rifaximin decreases virulence of Crohn\u2019s disease-associated Escherichia coli and epithelial inflammatory responses","volume":"71","author":"Dogan","year":"2018","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.phrs.2020.104936_bib0190","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3920\/BM2017.0107","article-title":"Lactobacillus fermentum L930BB and Bifidobacterium animalis subsp. animalis IM386 initiate signalling pathways involved in intestinal epithelial barrier protection","volume":"9","author":"Paveljsek","year":"2018","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.phrs.2020.104936_bib0195","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1080\/03007995.2017.1292230","article-title":"Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis","volume":"33","author":"Yuan","year":"2017","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.phrs.2020.104936_bib0200","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3920\/BM2017.0105","article-title":"Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study","volume":"9","author":"Preston","year":"2018","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.phrs.2020.104936_bib0205","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1053\/j.gastro.2013.10.026","article-title":"Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats","volume":"146","author":"Xu","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2020.104936_bib0210","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/jgh.13841","article-title":"Beneficial effects of Rifaximin in post-infectious irritable bowel syndrome mouse model beyond gut microbiota","volume":"33","author":"Jin","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2020.104936_bib0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071806","article-title":"Fungi of the murine gut: episodic variation and proliferation during antibiotic treatment","volume":"8","author":"Dollive","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2020.104936_bib0220","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1136\/gutjnl-2015-310746","article-title":"Fungal microbiota dysbiosis in IBD","volume":"66","author":"Sokol","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2020.104936_bib0225","article-title":"Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease","author":"Imai","year":"2018","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.phrs.2020.104936_bib0230","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.3693","article-title":"Association of host genome with intestinal microbial composition in a large healthy cohort","volume":"48","author":"Turpin","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2020.104936_bib0235","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.chom.2016.04.017","article-title":"Genetic determinants of the gut microbiome in UK twins","volume":"19","author":"Goodrich","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phrs.2020.104936_bib0240","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/ng.3695","article-title":"Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota","volume":"48","author":"Wang","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.phrs.2020.104936_bib0245","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nature25973","article-title":"Environment dominates over host genetics in shaping human gut microbiota","volume":"555","author":"Rothschild","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2020.104936_bib0250","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.cell.2018.10.029","article-title":"US immigration westernizes the human gut microbiome","volume":"175","author":"Vangay","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2020.104936_bib0255","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrmicro3552","article-title":"Gut biogeography of the bacterial microbiota","volume":"14","author":"Donaldson","year":"2016","journal-title":"Nat. Rev. Microbiol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820312445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820312445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:15:12Z","timestamp":1760912112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661820312445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":51,"alternative-id":["S1043661820312445"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104936","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fecal bacteria can predict the efficacy of rifaximin in patients with diarrhea-predominant irritable bowel syndrome","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104936","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104936"}}