{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:04:41Z","timestamp":1790730281270,"version":"4.1.0"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.phrs.2020.104945","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T11:39:48Z","timestamp":1590233988000},"page":"104945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe"],"prefix":"10.1016","volume":"159","author":[{"given":"Xiaofei","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binxin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qingxiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangmao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2020.104945_bib0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2020.104945_bib0010","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"issue":"386","key":"10.1016\/j.phrs.2020.104945_bib0015","first-page":"1546","article-title":"Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and","volume":"2015","author":"Schweitzer","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2020.104945_bib0020","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.2012.39","article-title":"Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010","volume":"307","author":"Flegal","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2020.104945_bib0025","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1056\/NEJMra1503519","article-title":"Pathogenesis, and treatment of nonalcoholic steatohepatitis","volume":"377","author":"Diehl","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2020.104945_bib0030","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00535-016-1264-3","article-title":"Nonalcoholic fatty liver disease in Asia: emerging perspectives","volume":"52","author":"Seto","year":"2017","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.phrs.2020.104945_bib0035","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1054\/bjoc.1999.1597","article-title":"Betel quid chewing as a risk factor for hepatocellular carcinoma: a case-control study","volume":"84","author":"Tsai","year":"2001","journal-title":"Br. J. Cancer"},{"issue":"12","key":"10.1016\/j.phrs.2020.104945_bib0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12916-014-0145-y","article-title":"Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis","author":"Mokdad","year":"2014","journal-title":"BMC Med."},{"key":"10.1016\/j.phrs.2020.104945_bib0045","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4103\/2225-4110.114898","article-title":"Therapeutic potential of traditional chinese medicine on inflammatory diseases","volume":"3","author":"Tsai","year":"2013","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.phrs.2020.104945_bib0050","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3748\/wjg.v23.i7.1125","article-title":"Therapeutic mechanism of Yin-Chen-Hao decoction in hepatic diseases","volume":"23","author":"Li","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2020.104945_bib0055","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/hepr.12299","article-title":"Current scenario for the hepatoprotective effects of Inchinkoto, a traditional herbal medicine, and its clinical application in liver surgery: a review","volume":"44","author":"Yokoyama","year":"2014","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.phrs.2020.104945_bib0060","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1248\/bpb.27.1580","article-title":"Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora","volume":"27","author":"Yim","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phrs.2020.104945_bib0065","doi-asserted-by":"crossref","DOI":"10.1111\/hepr.12985","article-title":"Does the intestinal microenvironment have an impact on the choleretic effect of inchinkoto, a hepatoprotective herbal medicine?","volume":"48","author":"Uji","year":"2018","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.phrs.2020.104945_bib0070","doi-asserted-by":"crossref","first-page":"8938","DOI":"10.1038\/s41598-017-09131-2","article-title":"Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation","volume":"7","author":"Tian","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2020.104945_bib0075","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s40263-016-0369-9","article-title":"Therapeutic potential of genipin in central neurodegenerative diseases","volume":"30","author":"Li","year":"2016","journal-title":"CNS Drugs"},{"key":"10.1016\/j.phrs.2020.104945_bib0080","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.phrs.2018.05.007","article-title":"Potential role of genipin in cancer therapy","volume":"133","author":"Shanmugam","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2020.104945_bib0085","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.14336\/AD.2018.0112","article-title":"Therapeutic potential and effective components of the chinese Herb Gardeniae Fructus in the treatment of senile disease","volume":"9","author":"Lv","year":"2018","journal-title":"Aging Dis."},{"key":"10.1016\/j.phrs.2020.104945_bib0090","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12470","article-title":"Comparative evaluation of decellularized porcine liver matrices crosslinked with different chemical and natural crosslinking agents","volume":"26","author":"Gao","year":"2019","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.phrs.2020.104945_bib0095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/jbm.a.32975","article-title":"Genipin-crosslinked microcarriers mediating hepatocellular aggregates formation and functionalities","volume":"96","author":"Lau","year":"2011","journal-title":"J. Biomed. Mater. Res. A."},{"key":"10.1016\/j.phrs.2020.104945_bib0100","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1002\/jbm.a.35717","article-title":"Preparation, characterization, and evaluation of genipin crosslinked chitosan\/gelatin three-dimensional scaffolds for liver tissue engineering applications","volume":"104","author":"Zhang","year":"2016","journal-title":"J. Biomed. Mater. Res. A."},{"key":"10.1016\/j.phrs.2020.104945_bib0105","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1248\/bpb1978.4.612","article-title":"Pharmacological studies on iridoid compounds. III. The choleretic mechanism of iridoid compounds","volume":"4","author":"Takeda","year":"1981","journal-title":"J. Pharmacobio-Dyn."},{"key":"10.1016\/j.phrs.2020.104945_bib0110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/hep.20003","article-title":"Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver","volume":"39","author":"Shoda","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.phrs.2020.104945_bib0115","doi-asserted-by":"crossref","first-page":"G1450","DOI":"10.1152\/ajpgi.00302.2006","article-title":"Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2\/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers","volume":"292","author":"Okada","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.phrs.2020.104945_bib0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jep.2015.09.012","article-title":"Synergistic effects of rhubarb-gardenia herb pair in cholestatic rats at pharmacodynamic and pharmacokinetic levels","volume":"175","author":"Dong","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2020.104945_bib0125","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jhep.2018.10.023","article-title":"Inflammatory pathways in alcoholic steatohepatitis","volume":"70","author":"Gao","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2020.104945_bib0130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12072-018-9911-9","article-title":"DAMPs and sterile inflammation in drug hepatotoxicity","volume":"13","author":"Yang","year":"2019","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.phrs.2020.104945_bib0135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2020.104945_bib0140","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92634","article-title":"Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicity","volume":"2","author":"Cai","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.phrs.2020.104945_bib0145","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2119\/molmed.2011.00308","article-title":"Genipin attenuates sepsis by inhibiting Toll-like receptor signaling","volume":"18","author":"Kim","year":"2012","journal-title":"Mol Med"},{"key":"10.1016\/j.phrs.2020.104945_bib0150","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jep.2009.11.029","article-title":"Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis","volume":"127","author":"Mase","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2020.104945_bib0155","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","article-title":"Acute liver failure","volume":"394","author":"Stravitz","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2020.104945_bib0160","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3946706","article-title":"The protective effect of Cordycepin on D-Galactosamine\/Lipopolysaccharide-Induced acute liver injury","volume":"2017","author":"Li","year":"2017","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phrs.2020.104945_bib0165","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.intimp.2014.07.008","article-title":"Role of alpha-lipoic acid in LPS\/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis","volume":"22","author":"Xia","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2020.104945_bib0170","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.hepres.2005.08.009","article-title":"Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production","volume":"33","author":"Takeuchi","year":"2005","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.phrs.2020.104945_bib0175","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejphar.2017.07.024","article-title":"Genipin protects d-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling","volume":"812","author":"Seo","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2020.104945_bib0180","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1039\/C8FO01078A","article-title":"Polydatin protects against acetaminophen-induced hepatotoxicity in mice via anti-oxidative and anti-apoptotic activities","volume":"9","author":"Liu","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.phrs.2020.104945_bib0185","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8506195","article-title":"The beneficial roles of SIRT1 in drug-induced liver injury","volume":"2019","author":"Yan","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phrs.2020.104945_bib0190","doi-asserted-by":"crossref","DOI":"10.1080\/10408398.2018.1544542","article-title":"n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: a critical review","volume":"59","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phrs.2020.104945_bib0195","doi-asserted-by":"crossref","DOI":"10.3390\/biom6030029","article-title":"Role of transcription factors in steatohepatitis and hypertension after ethanol: the epicenter of metabolism","volume":"6","author":"Ansari","year":"2016","journal-title":"Biomolecules"},{"key":"10.1016\/j.phrs.2020.104945_bib0200","doi-asserted-by":"crossref","first-page":"F840","DOI":"10.1152\/ajprenal.00187.2002","article-title":"Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS","volume":"284","author":"Chien","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.phrs.2020.104945_bib0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047299","article-title":"Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney","volume":"7","author":"Chung","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2020.104945_bib0210","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.2147\/DDDT.S172612","article-title":"Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review","volume":"12","author":"Sova","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phrs.2020.104945_bib0215","article-title":"The effects of dietary supplements that overactivate the Nrf2\/ARE system","author":"Smith","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phrs.2020.104945_bib0220","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2015.04.036","article-title":"The emerging role of Nrf2 in mitochondrial function","volume":"88","author":"Dinkova-Kostova","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2020.104945_bib0225","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1142\/S0192415X09006886","article-title":"In-chern-hau-tang and genipin reduces acute urinary bladder distension evoked sympathetic activation-induced hepatic dysfunction in rats","volume":"37","author":"Yen","year":"2009","journal-title":"Am. J. Chin. Med. (Gard City N Y)"},{"key":"10.1016\/j.phrs.2020.104945_bib0230","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.exger.2013.09.001","article-title":"Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction","volume":"48","author":"Guan","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.phrs.2020.104945_bib0235","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4062\/biomolther.2013.005","article-title":"Protective effects of geniposide and genipin against hepatic Ischemia\/Reperfusion injury in mice","volume":"21","author":"Kim","year":"2013","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.phrs.2020.104945_bib0240","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2174\/1872312810666161020164658","article-title":"Genipin inhibits the induction of inducible nitric oxide synthase through the inhibition of NF-kappaB activation in rat hepatocytes","volume":"10","author":"Nakatake","year":"2017","journal-title":"Drug Metab. Lett."},{"key":"10.1016\/j.phrs.2020.104945_bib0245","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1053\/gast.2002.36061","article-title":"AGA technical review on the evaluation of liver chemistry tests","volume":"123","author":"Green","year":"2002","journal-title":"Gastroenterology"},{"issue":"25","key":"10.1016\/j.phrs.2020.104945_bib0250","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2020.104945_bib0255","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5009\/gnl18486","article-title":"Tsukamoto H. Cell death and liver disease","volume":"14","author":"Aizawa","year":"2020","journal-title":"Gut Liver"},{"key":"10.1016\/j.phrs.2020.104945_bib0260","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/acer.13078","article-title":"A mechanistic review of cell death in alcohol-induced liver injury","volume":"40","author":"Wang","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.phrs.2020.104945_bib0265","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1152\/physrev.00061.2009","article-title":"Hepatocyte death: a clear and present danger","volume":"90","author":"Malhi","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2020.104945_bib0270","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1053\/jhep.2003.50472","article-title":"Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression","volume":"38","author":"Canbay","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.phrs.2020.104945_bib0275","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nri.2015.7","article-title":"Converging roles of caspases in inflammasome activation, cell death and innate immunity","volume":"16","author":"Man","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2020.104945_bib0280","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0016-5085(00)70220-4","article-title":"Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice","volume":"118","author":"Yamamoto","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2020.104945_bib0285","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejphar.2010.03.007","article-title":"Genipin protects lipopolysaccharide-induced apoptotic liver damage in D-galactosamine-sensitized mice","volume":"635","author":"Kim","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2020.104945_bib0290","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1056\/NEJMra0901217","article-title":"Cell death","volume":"361","author":"Hotchkiss","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2020.104945_bib0295","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/00003246-199907000-00002","article-title":"Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction","volume":"27","author":"Hotchkiss","year":"1999","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.phrs.2020.104945_bib0300","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.intimp.2015.04.034","article-title":"Genipin attenuates sepsis-induced immunosuppression through inhibition of T lymphocyte apoptosis","volume":"27","author":"Kim","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2020.104945_bib0305","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2020.104945_bib0310","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrgastro.2016.185","article-title":"Autophagy in the liver: functions in health and disease","volume":"14","author":"Ueno","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2020.104945_bib0315","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1080\/15384101.2015.1038685","article-title":"Autophagy and apoptosis in liver injury","volume":"14","author":"Wang","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.phrs.2020.104945_bib0320","doi-asserted-by":"crossref","first-page":"17935","DOI":"10.1038\/srep17935","article-title":"Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression","volume":"5","author":"Yu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2020.104945_bib0325","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/bph.13397","article-title":"Genipin alleviates sepsis-induced liver injury by restoring autophagy","volume":"173","author":"Cho","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2020.104945_bib0330","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3729051","article-title":"Genipin ameliorates carbon tetrachloride-induced liver injury in mice via the concomitant inhibition of inflammation and induction of autophagy","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phrs.2020.104945_bib0335","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/cdd.2017.65","article-title":"Initiation and execution mechanisms of necroptosis: an overview","volume":"24","author":"Grootjans","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2020.104945_bib0340","doi-asserted-by":"crossref","first-page":"e1975","DOI":"10.1038\/cddis.2015.316","article-title":"Role of necroptosis in the pathogenesis of solid organ injury","volume":"6","author":"Zhao","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phrs.2020.104945_bib0345","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/cr.2013.171","article-title":"Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death","volume":"24","author":"Chen","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.phrs.2020.104945_bib0350","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2020.104945_bib0355","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1159\/000493651","article-title":"Genipin reverses HFD-Induced liver damage and inhibits UCP2-Mediated pyroptosis in mice","volume":"49","author":"Zhong","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.phrs.2020.104945_bib0360","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.freeradbiomed.2007.12.029","article-title":"Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases","volume":"44","author":"Mantena","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2020.104945_bib0365","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9100233","article-title":"Mitochondrial dysfunction in the transition from NASH to HCC","volume":"9","author":"Leveille","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.phrs.2020.104945_bib0370","article-title":"OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism","author":"Dai","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2020.104945_bib0375","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molmed.2011.08.003","article-title":"Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism","volume":"18","author":"Diano","year":"2012","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.phrs.2020.104945_bib0380","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3389\/fphys.2018.01060","article-title":"Uncoupling Protein 2 in Cardiovascular Health and Disease","volume":"9","author":"Tian","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phrs.2020.104945_bib0385","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2174\/1874609811003020102","article-title":"Uncoupling protein-2 and the potential link between metabolism and longevity","volume":"3","author":"Andrews","year":"2010","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.phrs.2020.104945_bib0390","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0092-8674(01)00378-6","article-title":"Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes","volume":"105","author":"Zhang","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2020.104945_bib0395","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/415096a","article-title":"Superoxide activates mitochondrial uncoupling proteins","volume":"415","author":"Echtay","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2020.104945_bib0400","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cmet.2006.04.010","article-title":"Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets","volume":"3","author":"Zhang","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2020.104945_bib0405","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/hep.23121","article-title":"Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to lipopolysaccharide\/galactosamine-induced acute liver injury","volume":"50","author":"Shang","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.phrs.2020.104945_bib0410","first-page":"1327","article-title":"[Influence of genipin and vitamin E on UCP2 and other correlation factors in non-alcoholic fatty liver disease]","volume":"27","author":"Lin","year":"2010","journal-title":"Sheng Wu Yi Xue Gong Cheng Xue Za Zhi"},{"key":"10.1016\/j.phrs.2020.104945_bib0415","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/1476-511X-11-154","article-title":"Inhibition of uncoupling protein 2 with genipin exacerbates palmitate-induced hepatic steatosis","volume":"11","author":"Ma","year":"2012","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.phrs.2020.104945_bib0420","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/810401","article-title":"Uncoupling protein 2 regulates palmitic acid-induced hepatoma cell autophagy","volume":"2014","author":"Lou","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.phrs.2020.104945_bib0425","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial dysfunction and signaling in chronic liver diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2020.104945_bib0430","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s12035-010-8150-4","article-title":"Mitochondrial quality control and Parkinson\u2019s disease: a pathway unfolds","volume":"43","author":"de Castro","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2020.104945_bib0435","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/emboj.2012.38","article-title":"Mitochondrial quality control: a matter of life and death for neurons","volume":"31","author":"Rugarli","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.phrs.2020.104945_bib0440","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.taap.2017.05.002","article-title":"Genipin protects the liver from ischemia\/reperfusion injury by modulating mitochondrial quality control","volume":"328","author":"Shin","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2020.104945_bib0445","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jhep.2004.06.033","article-title":"Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis","volume":"41","author":"Inao","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2020.104945_bib0450","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1248\/bpb.34.1613","article-title":"Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic mice and free fatty acid-treated HepG2 cells","volume":"34","author":"Kojima","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phrs.2020.104945_bib0455","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/febs.14349","article-title":"Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p\/SREBP-1c axis","volume":"285","author":"Zhong","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.phrs.2020.104945_bib0460","first-page":"72","article-title":"SREBP-1c transcription factor and lipid homeostasis: clinical perspective","volume":"68","author":"Ferre","year":"2007","journal-title":"Horm. Res."},{"key":"10.1016\/j.phrs.2020.104945_bib0465","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/ptr.6022","article-title":"Genipin ameliorates diet-induced obesity via promoting lipid mobilization and browning of white adipose tissue in rats","volume":"32","author":"Guan","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phrs.2020.104945_bib0470","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0278-6915(02)00118-7","article-title":"Genotoxicity of gardenia yellow and its components","volume":"40","author":"Ozaki","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phrs.2020.104945_bib0475","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.fct.2018.06.001","article-title":"Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin","volume":"118","author":"Hobbs","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phrs.2020.104945_bib0480","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s12272-012-0418-y","article-title":"Role of metabolism by human intestinal microflora in geniposide-induced toxicity in HepG2 cells","volume":"35","author":"Kang","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.phrs.2020.104945_bib0485","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1021\/acs.chemrestox.6b00274","article-title":"Drug-protein adducts: chemistry, mechanisms of toxicity, and methods of characterization","volume":"29","author":"Gan","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.phrs.2020.104945_bib0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114624","article-title":"Role of intestinal microbiota-mediated genipin dialdehyde intermediate formation in geniposide-induced hepatotoxicity in rats","volume":"377","author":"Li","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2020.104945_bib0495","article-title":"Screening of the hepatotoxic components in Fructus Gardeniae and their effects on rat liver BRL-3A cells","volume":"24","author":"Li","year":"2019","journal-title":"Molecules"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820312536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820312536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:11:04Z","timestamp":1760911864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661820312536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":99,"alternative-id":["S1043661820312536"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104945","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.104945","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104945"}}