{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:14:34Z","timestamp":1790486074798,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.phrs.2020.105067","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T12:40:35Z","timestamp":1594125635000},"page":"105067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Antibacterial and antibiofilm effects of flufenamic acid against methicillin-resistant Staphylococcus aureus"],"prefix":"10.1016","volume":"160","author":[{"given":"Shutao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin\u2019en","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-1554","authenticated-orcid":false,"given":"Hongtao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weien","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phrs.2020.105067_bib0005","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13018-019-1224-8","article-title":"Economic burden of surgical site infections within the episode of care following joint replacement","volume":"14","author":"Adeyemi","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"issue":"8","key":"10.1016\/j.phrs.2020.105067_bib0010","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1001\/jamasurg.2017.0904","article-title":"Centers for disease control and prevention guideline for the prevention of surgical site infection, 2017","volume":"152","author":"Berrios-Torres","year":"2017","journal-title":"JAMA Surg."},{"issue":"5","key":"10.1016\/j.phrs.2020.105067_bib0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ajic.2008.12.010","article-title":"Surgical site infection: incidence and impact on hospital utilization and treatment costs","volume":"37","author":"de Lissovoy","year":"2009","journal-title":"Am. J. Infect. Control"},{"issue":"4","key":"10.1016\/j.phrs.2020.105067_bib0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1086\/502033","article-title":"The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost","volume":"23","author":"Whitehouse","year":"2002","journal-title":"Infect. Control Hosp. Epidemiol."},{"issue":"5","key":"10.1016\/j.phrs.2020.105067_bib0025","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S1473-3099(17)30059-2","article-title":"Effect of laminar airflow ventilation on surgical site infections: a systematic review and meta-analysis","volume":"17","author":"Bischoff","year":"2017","journal-title":"Lancet Infect. Dis."},{"issue":"2","key":"10.1016\/j.phrs.2020.105067_bib0030","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1053\/jhin.2001.1052","article-title":"Implant infections: a haven for opportunistic bacteria","volume":"49","author":"Schierholz","year":"2001","journal-title":"J. Hosp. Infect."},{"issue":"9","key":"10.1016\/j.phrs.2020.105067_bib0035","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1086\/323130","article-title":"Device-associated infections: a macroproblem that starts with microadherence","volume":"33","author":"Darouiche","year":"2001","journal-title":"Clin. Infect. Dis."},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0040","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.immuni.2011.12.003","article-title":"The multitasking organ: recent insights into skin immune function","volume":"35","author":"Di Meglio","year":"2011","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.phrs.2020.105067_bib0045","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2020.105067_bib0050","doi-asserted-by":"crossref","DOI":"10.1111\/1468-0009.12405","article-title":"Less is more: Norwegian drug regulation, antibiotic policy, and the \u201cNeed Clause\u201d","author":"Hobaek","year":"2019","journal-title":"Milbank Q."},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0055","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.arcmed.2005.06.009","article-title":"Resistance to antibiotics: are we in the post-antibiotic era?","volume":"36","author":"Alanis","year":"2005","journal-title":"Arch. Med. Res."},{"issue":"9172","key":"10.1016\/j.phrs.2020.105067_bib0060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0140-6736(99)00874-0","article-title":"Postoperative pain and subcutaneous oxygen tension","volume":"354","author":"Akca","year":"1999","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.phrs.2020.105067_bib0065","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S1098-3597(01)90069-9","article-title":"Understanding NSAIDs: from aspirin to COX-2","volume":"3","author":"Green","year":"2001","journal-title":"Clin. Cornerstone"},{"issue":"6891","key":"10.1016\/j.phrs.2020.105067_bib0070","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1136\/bmj.306.6891.1493","article-title":"NSAIDs and postoperative pain","volume":"306","author":"Murphy","year":"1993","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.phrs.2020.105067_bib0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/bja\/88.2.199","article-title":"Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review","volume":"88","author":"Hyllested","year":"2002","journal-title":"Br. J. Anaesth."},{"issue":"20","key":"10.1016\/j.phrs.2020.105067_bib0080","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1001\/jama.282.20.1961","article-title":"COX-1-sparing NSAIDs--is the enthusiasm justified?","volume":"282","author":"Peterson","year":"1999","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.phrs.2020.105067_bib0085","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00404-019-05256-z","article-title":"Prevention and treatment of uncomplicated lower urinary tract infections in the era of increasing antimicrobial resistance-non-antibiotic approaches: a systemic review","volume":"300","author":"Wawrysiuk","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"issue":"1","key":"10.1016\/j.phrs.2020.105067_bib0090","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijantimicag.2013.08.018","article-title":"In vitro analysis of flufenamic acid activity against Candida albicans biofilms","volume":"43","author":"Chavez-Dozal","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0095","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s40259-016-0200-7","article-title":"Identification of potential therapeutics to conquer drug resistance in Salmonella typhimurium: drug repurposing strategy","volume":"30","author":"Preethi","year":"2016","journal-title":"BioDrugs"},{"key":"10.1016\/j.phrs.2020.105067_bib0100","series-title":"CLSI Document M07-A10","article-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standard","author":"CLSI","year":"2015"},{"issue":"1","key":"10.1016\/j.phrs.2020.105067_bib0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41467-017-02123-w","article-title":"Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria","volume":"9","author":"Blaskovich","year":"2018","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0110","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1128\/AAC.00039-06","article-title":"Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus","volume":"50","author":"Friedman","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phrs.2020.105067_bib0115","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1471-2180-13-212","article-title":"The two peptide lantibiotic lacticin 3147 acts synergistically with polymyxin to inhibit Gram negative bacteria","volume":"13","author":"Draper","year":"2013","journal-title":"BMC Microbiol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105067_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","author":"Odds","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"issue":"2","key":"10.1016\/j.phrs.2020.105067_bib0125","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3892\/mmr.2014.2264","article-title":"Cultivation and identification of rat bone marrow-derived mesenchymal stem cells","volume":"10","author":"Song","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2020.105067_bib0130","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1128\/AAC.00603-08","article-title":"Ultrastructural effects of oritavancin on methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus","volume":"53","author":"Belley","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phrs.2020.105067_bib0135","series-title":"Specimen Preparation for Scanning Electron Microscopy","author":"Stutzman","year":"1999"},{"key":"10.1016\/j.phrs.2020.105067_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.12.003","article-title":"Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145","volume":"222","author":"de Breij","year":"2016","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.phrs.2020.105067_bib0145","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12906-019-2558-9","article-title":"Antimicrobial characteristics of Berberine against prosthetic joint infection-related Staphylococcus aureus of different multi-locus sequence types","volume":"19","author":"Tan","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"issue":"51","key":"10.1016\/j.phrs.2020.105067_bib0150","doi-asserted-by":"crossref","first-page":"E5555","DOI":"10.1073\/pnas.1415610111","article-title":"Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection","volume":"111","author":"Yeaman","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.phrs.2020.105067_bib0155","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1128\/JB.00655-08","article-title":"NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses","volume":"190","author":"Ding","year":"2008","journal-title":"J. Bacteriol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105067_bib0160","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/bph.14153","article-title":"Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers","volume":"175","author":"Curtis","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"15","key":"10.1016\/j.phrs.2020.105067_bib0165","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1242\/jeb.204.15.2597","article-title":"Structure-function relationships of A-, F- and V-ATPases","volume":"204","author":"Gruber","year":"2001","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.phrs.2020.105067_bib0170","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1146\/annurev.micro.50.1.791","article-title":"The F0F1-type ATP synthases of bacteria: structure and function of the F0 complex","volume":"50","author":"Deckers-Hebestreit","year":"1996","journal-title":"Annu. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.phrs.2020.105067_bib0175","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.170275","article-title":"Insights into the regulatory function of the varepsilon subunit from bacterial F-type ATP synthases: a comparison of structural, biochemical and biophysical data","volume":"8","author":"Krah","year":"2018","journal-title":"Open Biol."},{"issue":"11","key":"10.1016\/j.phrs.2020.105067_bib0180","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1172\/JCI200320442","article-title":"Quorum sensing in Staphylococcus infections","volume":"112","author":"Yarwood","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.phrs.2020.105067_bib0185","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1172\/JCI20074","article-title":"Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections","volume":"112","author":"Hentzer","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0190","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1128\/AAC.00045-11","article-title":"Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo","volume":"55","author":"Brackman","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0195","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1128\/AAC.01097-06","article-title":"Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP","volume":"51","author":"Balaban","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.phrs.2020.105067_bib0200","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.chembiol.2012.11.013","article-title":"Discovery of wall teichoic acid inhibitors as potential anti-MRSA beta-lactam combination agents","volume":"20","author":"Wang","year":"2013","journal-title":"Chem. Biol."},{"issue":"8","key":"10.1016\/j.phrs.2020.105067_bib0205","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/cbic.201100120","article-title":"Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway","volume":"12","author":"Rausch","year":"2011","journal-title":"Chembiochem"},{"issue":"5","key":"10.1016\/j.phrs.2020.105067_bib0210","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1368-7646(98)80048-4","article-title":"Role of fem factors in methicillin resistance","volume":"1","author":"Berger-Bachi","year":"1998","journal-title":"Drug Resist. Updat."},{"issue":"7","key":"10.1016\/j.phrs.2020.105067_bib0215","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1086\/589331","article-title":"Economic burden of surgical site infections at a European university hospital","volume":"29","author":"Weber","year":"2008","journal-title":"Infect. Control Hosp. Epidemiol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105067_bib0220","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1473-3099(01)00091-3","article-title":"Vancomycin-resistant Staphylococcus aureus\u202f: a new model of antibiotic resistance","volume":"1","author":"Hiramatsu","year":"2001","journal-title":"Lancet Infect. Dis."},{"issue":"4","key":"10.1016\/j.phrs.2020.105067_bib0225","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/jac\/25.4.679","article-title":"Nephrotoxicity of vancomycin, alone and with an aminoglycoside","volume":"25","author":"Rybak","year":"1990","journal-title":"J. Antimicrob. Chemother."},{"issue":"4","key":"10.1016\/j.phrs.2020.105067_bib0230","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.chembiol.2014.02.009","article-title":"DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs","volume":"21","author":"Yin","year":"2014","journal-title":"Chem. Biol."},{"issue":"8","key":"10.1016\/j.phrs.2020.105067_bib0235","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s10096-009-0739-z","article-title":"The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target","volume":"28","author":"Mazumdar","year":"2009","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"4","key":"10.1016\/j.phrs.2020.105067_bib0240","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/infdis\/166.4.861","article-title":"The use of nonsteroidal antiinflammatory drugs to prevent adherence of Staphylococcus epidermidis to medical polymers","volume":"166","author":"Farber","year":"1992","journal-title":"J. Infect. Dis."},{"issue":"7","key":"10.1016\/j.phrs.2020.105067_bib0245","first-page":"846","article-title":"Celecoxib inhibits Helicobacter pylori colonization-related factors","volume":"16","author":"Wang","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2020.105067_bib0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106014","article-title":"Flufenamic acid inhibits osteoclast formation and bone resorption and act against estrogen-dependent bone loss in mice","volume":"78","author":"Zhang","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105067_bib0255","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13287-019-1321-y","article-title":"Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-kappaB signaling pathway","volume":"10","author":"Liu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0260","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.3892\/ijo.2013.1891","article-title":"Flufenamic acid promotes angiogenesis through AMPK activation","volume":"42","author":"Ge","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phrs.2020.105067_bib0265","doi-asserted-by":"crossref","first-page":"12504","DOI":"10.1038\/ncomms12504","article-title":"Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer\u2019s disease in rodent models","volume":"7","author":"Daniels","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2020.105067_bib0270","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3201\/eid2501.171862","article-title":"Surgical site infections caused by highly virulent methicillin-resistant Staphylococcus aureus sequence type 398, China","volume":"25","author":"Sun","year":"2019","journal-title":"Emerg. Infect. Dis."},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0275","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00264-018-4076-7","article-title":"Microbiological profile and susceptibility pattern of surgical site infections related to orthopaedic trauma","volume":"43","author":"Tuon","year":"2019","journal-title":"Int. Orthop."},{"issue":"21","key":"10.1016\/j.phrs.2020.105067_bib0280","first-page":"1970","article-title":"National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011","volume":"173","author":"Dantes","year":"2013","journal-title":"JAMA Intern. Med."},{"issue":"5","key":"10.1016\/j.phrs.2020.105067_bib0285","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1128\/AAC.19.5.726","article-title":"Altered penicillin-binding proteins in methicillin-resistant strains of Staphylococcus aureus","volume":"19","author":"Hartman","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.phrs.2020.105067_bib0290","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/cid\/ciy399","article-title":"National costs associated with methicillin-susceptible and methicillin-resistant Staphylococcus aureus hospitalizations in the United States, 2010-2014","volume":"68","author":"Klein","year":"2019","journal-title":"Clin. Infect. Dis."},{"issue":"2\u20133","key":"10.1016\/j.phrs.2020.105067_bib0295","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijmm.2009.10.005","article-title":"An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway","volume":"300","author":"Schneider","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105067_bib0300","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1053\/gast.2000.16497","article-title":"Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice","volume":"119","author":"Beck","year":"2000","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0305","doi-asserted-by":"crossref","first-page":"429","DOI":"10.7326\/0003-4819-127-6-199709150-00003","article-title":"Unnecessary prescribing of NSAIDs and the management of NSAID-related gastropathy in medical practice","volume":"127","author":"Tamblyn","year":"1997","journal-title":"Ann. Intern. Med."},{"issue":"6","key":"10.1016\/j.phrs.2020.105067_bib0310","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/0016-5085(93)90667-2","article-title":"Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans","volume":"104","author":"Bjarnason","year":"1993","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.phrs.2020.105067_bib0315","first-page":"522","article-title":"Nanoparticles modified by polydopamine: working as \u201cdrug\u201d carriers","volume":"5","author":"Jin","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.phrs.2020.105067_bib0320","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.micpath.2014.07.008","article-title":"Aspirin is an efficient inhibitor of quorum sensing, virulence and toxins in Pseudomonas aeruginosa","volume":"74","author":"El-Mowafy","year":"2014","journal-title":"Microb. Pathog."},{"issue":"8","key":"10.1016\/j.phrs.2020.105067_bib0325","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1021\/acschembio.5b01050","article-title":"Rapid inhibition profiling in Bacillus subtilis to identify the mechanism of action of new antimicrobials","volume":"11","author":"Lamsa","year":"2016","journal-title":"ACS Chem. Biol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182031375X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182031375X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:10:25Z","timestamp":1760911825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366182031375X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":65,"alternative-id":["S104366182031375X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105067","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibacterial and antibiofilm effects of flufenamic acid against methicillin-resistant Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105067"}}