{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:45:37Z","timestamp":1792568737258,"version":"4.5.0"},"reference-count":291,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004351","name":"Sultan Qaboos University","doi-asserted-by":"publisher","award":["IG\/AGR\/FOOD\/17\/02"],"award-info":[{"award-number":["IG\/AGR\/FOOD\/17\/02"]}],"id":[{"id":"10.13039\/501100004351","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001230","name":"Macquarie University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.phrs.2020.105078","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:02:41Z","timestamp":1594677761000},"page":"105078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"special_numbering":"C","title":["Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders"],"prefix":"10.1016","volume":"160","author":[{"given":"Abid","family":"Bhat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipul","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arehally Marappa","family":"Mahalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunanda","family":"Tuladhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DN","family":"Nandakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malathi","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musthafa Mohamed","family":"Essa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravana Babu","family":"Chidambaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles J.","family":"Guillemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena Kishore","family":"Sakharkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2020.105078_bib0005","first-page":"S252","article-title":"Phosphodiesterase inhibitors","author":"B.Smith","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pharmthera.2005.07.003","article-title":"Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents","volume":"109","author":"Lugnier","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2020.105078_bib0015","first-page":"12","article-title":"Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C","author":"Uys","year":"2011","journal-title":"BMC Cell Biol."},{"issue":"14","key":"10.1016\/j.phrs.2020.105078_bib0020","doi-asserted-by":"crossref","first-page":"11189","DOI":"10.1074\/jbc.M006546200","article-title":"Myomegalin is a novel protein of the golgi\/centrosome that interacts with a cyclic nucleotide phosphodiesterase","volume":"276","author":"Verde","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.phrs.2020.105078_bib0025","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3389\/fphar.2018.01048","article-title":"Phosphodiesterase-4 inhibitors for the treatment of inflammatory diseases","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0030","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1471-4159.2005.03028.x","article-title":"Differential phosphodiesterase expression and cytosolic Ca2+ in human CNS tumour cells and in non-malignant and malignant cells of rat origin","volume":"93","author":"Vatter","year":"2005","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0035","doi-asserted-by":"crossref","first-page":"362","DOI":"10.18433\/J3S02V","article-title":"Effects of PDE4 pathway inhibition in rat experimental stroke","volume":"17","author":"Yang","year":"2014","journal-title":"J. Pharm. Pharm. Sci."},{"issue":"9","key":"10.1016\/j.phrs.2020.105078_bib0040","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/onc.2012.136","article-title":"Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF","volume":"32","author":"Pullamsetti","year":"2013","journal-title":"Oncogene."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0045","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12035-007-0025-y","article-title":"Function and dysfunction of CNG channels: insights from channelopathies and mouse models","volume":"35","author":"Biel","year":"2007","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0050","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.ajhg.2012.03.004","article-title":"Exome sequencing identifies PDE4D mutations in acrodysostosis","volume":"90","author":"Lee","year":"2012","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0055","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1523\/JNEUROSCI.5236-10.2011","article-title":"Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling","volume":"31","author":"Li","year":"2011","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0060","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ng1245","article-title":"The gene encoding phosphodiesterase 4D confers risk of ischemic stroke","volume":"35","author":"Gretarsdottir","year":"2003","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0065","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1210\/er.2013-1053","article-title":"Clinical and molecular genetics of the phosphodiesterases (PDEs)","volume":"35","author":"Azevedo","year":"2014","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jaad.2017.11.056","article-title":"Phosphodiesterase 4 inhibitors","volume":"78","author":"Zebda","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105078_bib0075","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1080\/13543784.2017.1364360","article-title":"Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer\u2019s disease","volume":"26","author":"Prickaerts","year":"2017","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib0080","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.tips.2019.10.006","article-title":"Phosphodiesterase type 4 inhibition in CNS diseases","volume":"40","author":"Blokland","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0085","first-page":"149","article-title":"Roflumilast (Daliresp)","volume":"37","author":"Baye","year":"2012","journal-title":"P T"},{"key":"10.1016\/j.phrs.2020.105078_bib0090","first-page":"105","article-title":"Otezla (Apremilast), an oral PDE-4 inhibitor, receives FDA approval for the treatment of patients with active psoriatic arthritis and plaque psoriasis","volume":"8","author":"Fala","year":"2015","journal-title":"Am. Health Drug Benefits"},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0095","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.rmed.2003.12.012","article-title":"PDE4 inhibitors in COPD\u2014a more selective approach to treatment","volume":"98","author":"Vignola","year":"2004","journal-title":"Respir. Med."},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/jop.2005.21.315","article-title":"Case report: association of combined nonarteritic anterior ischemic optic neuropathy (NAION) and obstruction of cilioretinal artery with overdose of Viagra","volume":"21","author":"Akash","year":"2005","journal-title":"J. Ocul. Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib0105","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1001\/archoto.2010.51","article-title":"Phosphodiesterase type 5 inhibitor use and hearing impairment","volume":"136","author":"McGwin","year":"2010","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"issue":"9","key":"10.1016\/j.phrs.2020.105078_bib0110","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1097\/00004647-200209000-00010","article-title":"The phosphodiesterase 5 inhibitor sildenafil has No effect on cerebral blood flow or blood velocity","volume":"22","author":"Kruuse","year":"2002","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0115","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1741-7015-11-96","article-title":"Phosphodiesterase 4-targeted treatments for autoimmune diseases","volume":"11","author":"Kumar","year":"2013","journal-title":"BMC Medicine"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0120","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1124\/jpet.110.173690","article-title":"GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization","volume":"337","author":"Tralau-Stewart","year":"2011","journal-title":"J Pharmacol Exp Ther."},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib0125","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1038\/mt.2016.175","article-title":"Targeted delivery of an anti-inflammatory PDE4 inhibitor to immune cells via an antibody\u2013drug conjugate","volume":"24","author":"Yu","year":"2016","journal-title":"Mol Ther."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/cts.12436","article-title":"Pharmacokinetic\/Pharmacodynamic modeling of the PDE4 inhibitor TAK-648 in type 2 diabetes: early translational approaches for human dose prediction","volume":"10","author":"Plock","year":"2017","journal-title":"Clin Transl Sci"},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib0135","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/1759720X10381432","article-title":"Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases","volume":"2","author":"Schett","year":"2010","journal-title":"Ther Adv Musculoskelet Dis."},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18040696","article-title":"Phosphodiesterase inhibitors as a therapeutic approach to neuroprotection and repair","volume":"18","author":"Knott","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0145","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2174\/1381612820666140826113731","article-title":"Phosphodiesterase inhibitors as therapeutics for traumatic brain injury","volume":"21","author":"Titus","year":"2014","journal-title":"Curr Pharm Des"},{"issue":"22","key":"10.1016\/j.phrs.2020.105078_bib0150","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S1359-6446(05)03622-6","article-title":"Keynote review: phosphodiesterase-4 as a therapeutic target","volume":"10","author":"Houslay","year":"2005","journal-title":"Drug Discov Today"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0155","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tibs.2009.09.007","article-title":"Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown","volume":"35","author":"Houslay","year":"2010","journal-title":"Trends Biochem Sci"},{"issue":"11","key":"10.1016\/j.phrs.2020.105078_bib0160","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.cellsig.2006.07.018","article-title":"Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579","volume":"18","author":"Hill","year":"2006","journal-title":"Cell Signal"},{"issue":"14","key":"10.1016\/j.phrs.2020.105078_bib0165","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.2174\/138161209788168092","article-title":"Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs","volume":"15","author":"Zhang","year":"2009","journal-title":"Curr Pharm Des."},{"issue":"5472","key":"10.1016\/j.phrs.2020.105078_bib0170","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1126\/science.288.5472.1822","article-title":"Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity","volume":"288","author":"Xu","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.phrs.2020.105078_bib0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/BJ20070970","article-title":"Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors","volume":"408","author":"Wang","year":"2007","journal-title":"Biochem J."},{"issue":"36","key":"10.1016\/j.phrs.2020.105078_bib0180","doi-asserted-by":"crossref","first-page":"22477","DOI":"10.1016\/S0021-9258(17)31669-1","article-title":"Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase","volume":"269","author":"Francis","year":"1994","journal-title":"J Biol Chem."},{"issue":"51","key":"10.1016\/j.phrs.2020.105078_bib0185","doi-asserted-by":"crossref","first-page":"30671","DOI":"10.1074\/jbc.270.51.30671","article-title":"An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase","volume":"270","author":"McAllister-Lucas","year":"1995","journal-title":"J Biol Chem"},{"issue":"45","key":"10.1016\/j.phrs.2020.105078_bib0190","doi-asserted-by":"crossref","first-page":"13220","DOI":"10.1021\/bi034653e","article-title":"The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis","volume":"42","author":"Huai","year":"2003","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0195","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0026-895X(25)10513-0","article-title":"Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3","volume":"48","author":"Alvarez","year":"1995","journal-title":"Mol Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0200","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0014-5793(94)01460-I","article-title":"Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)","volume":"358","author":"Engels","year":"1995","journal-title":"FEBS Lett."},{"issue":"3\u20134","key":"10.1016\/j.phrs.2020.105078_bib0205","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0891-0618(00)00097-1","article-title":"Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain","volume":"20","author":"P\u00e9rez-Torres","year":"2000","journal-title":"J Chem Neuroanat"},{"issue":"8","key":"10.1016\/j.phrs.2020.105078_bib0210","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrd2058","article-title":"Phosphodiesterases in the CNS: targets for drug development","volume":"5","author":"Menniti","year":"2006","journal-title":"Nature Reviews Drug Discovery"},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0215","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0896-6273(02)00828-0","article-title":"Function and regulation of CREB family transcription factors in the nervous system","volume":"35","author":"Lonze","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2020.105078_bib0220","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.brainres.2015.07.003","article-title":"Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP\/CREB signaling system","volume":"1622","author":"Jabaris","year":"2015","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0225","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00213-008-1273-x","article-title":"Selective phosphodiesterase inhibitors: a promising target for cognition enhancement","volume":"202","author":"Reneerkens","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.phrs.2020.105078_bib0230","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00255","article-title":"cAMP response element-binding protein (CREB): a possible signaling molecule link in the pathophysiology of schizophrenia","volume":"11","author":"Wang","year":"2018","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0235","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/sj.npp.1300813","article-title":"Subchronic rolipram delivery activates hippocampal CREB and arc, enhances retention and slows down extinction of conditioned fear","volume":"31","author":"Monti","year":"2006","journal-title":"Neuropsychopharmacology."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0240","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/hmg\/8.3.387","article-title":"Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism","volume":"8","author":"Oike","year":"1999","journal-title":"Hum Mol Genet."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0245","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.nlm.2008.04.016","article-title":"Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats","volume":"90","author":"Rutten","year":"2008","journal-title":"Neurobiol Learn Mem."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0250","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.1065.03.2004","article-title":"Activation of cAMP signaling facilitates the morphological maturation of newborn neurons in adult hippocampus","volume":"24","author":"Fujioka","year":"2004","journal-title":"J Neurosci"},{"issue":"11","key":"10.1016\/j.phrs.2020.105078_bib0255","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1038\/npp.2009.66","article-title":"Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus","volume":"34","author":"Li","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105078_bib0260","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.brainres.2003.08.007","article-title":"Different regulation of adenylyl cyclase and rolipram-sensitive phosphodiesterase activity on the frontal cortex and hippocampus in learned helplessness rats","volume":"991","author":"Itoh","year":"2003","journal-title":"Brain Res."},{"issue":"11","key":"10.1016\/j.phrs.2020.105078_bib0265","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2009.66","article-title":"Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 (PDE4) inhibitor rolipram on behavior depend on cyclic AMP-response element binding protein (CREB)-mediated neurogenesis in the hippocampus","volume":"34","author":"Li","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0270","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1042\/BJ20101010","article-title":"Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C","volume":"432","author":"Bird","year":"2010","journal-title":"Biochem J."},{"issue":"21","key":"10.1016\/j.phrs.2020.105078_bib0275","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1074\/jbc.274.21.14909","article-title":"The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform","volume":"274","author":"Yarwood","year":"1999","journal-title":"J Biol Chem."},{"issue":"8","key":"10.1016\/j.phrs.2020.105078_bib0280","doi-asserted-by":"crossref","first-page":"5710","DOI":"10.1073\/pnas.062046299","article-title":"NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1","volume":"99","author":"Yaka","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"10.1016\/j.phrs.2020.105078_bib0285","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1101\/lm.1114808","article-title":"The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK\/MAP kinase","volume":"15","author":"Ota","year":"2008","journal-title":"Learn Mem."},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0290","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/S0026-895X(24)08991-0","article-title":"Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole","volume":"63","author":"Chien","year":"2003","journal-title":"Mol Pharmacol."},{"key":"10.1016\/j.phrs.2020.105078_bib0295","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0079-6123(08)63206-9","article-title":"Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus","volume":"118","author":"Hawkins","year":"1998","journal-title":"Prog Brain Res"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0300","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1523\/JNEUROSCI.21-01-00143.2001","article-title":"Presynaptic role of cGMP-dependent protein kinase during long-lasting potentiation","volume":"21","author":"Arancio","year":"2001","journal-title":"J Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0305","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/S0026-895X(24)08991-0","article-title":"Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole","volume":"63","author":"Chien","year":"2003","journal-title":"Mol Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0310","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0166-2236(91)90022-M","article-title":"Glutamate, nitric oxide and cell-cell signalling in the nervous system","volume":"14","author":"Garthwaite","year":"1991","journal-title":"Trends Neurosci."},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib0315","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.neuropharm.2004.07.040","article-title":"Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance","volume":"47","author":"Boess","year":"2004","journal-title":"Neuropharmacology."},{"issue":"20","key":"10.1016\/j.phrs.2020.105078_bib0320","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.2174\/138161206777698855","article-title":"Improving memory: a role for phosphodiesterases","volume":"12","author":"Blokland","year":"2006","journal-title":"Curr Pharm Des"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0325","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2147\/NDT.S2447","article-title":"Role of phosphodiesterase 5 in synaptic plasticity and memory","volume":"4","author":"Puzzo","year":"2008","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"22","key":"10.1016\/j.phrs.2020.105078_bib0330","doi-asserted-by":"crossref","first-page":"8707","DOI":"10.1523\/JNEUROSCI.21-22-08707.2001","article-title":"Cyclic nucleotide-gated channels contribute to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons","volume":"21","author":"Kuzmiski","year":"2001","journal-title":"J Neurosci."},{"issue":"16","key":"10.1016\/j.phrs.2020.105078_bib0335","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1111\/bph.14377","article-title":"The phosphodiesterase 5 inhibitor, KJH\u20101002, reverses a mouse model of amnesia by activating a cGMP\/cAMP response element binding protein pathway and decreasing oxidative damage","volume":"175","author":"Zhang","year":"2018","journal-title":"Br J Pharmacol."},{"key":"10.1016\/j.phrs.2020.105078_bib0340","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev.pharmtox.42.082701.145401","article-title":"Molecular psychology: roles for the ERK MAP kinase cascade in memory","volume":"42","author":"Adams","year":"2002","journal-title":"Annu Rev Pharmacol Toxicol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105078_bib0345","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1523\/JNEUROSCI.23-09-03899.2003","article-title":"Differential role of mitogen-activated protein kinase in three distinct phases of memory for sensitization in Aplysia","volume":"23","author":"Sharma","year":"2003","journal-title":"J Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0350","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0896-6273(03)00030-8","article-title":"Activation of a tyrosine kinase-MAPK cascade enhances the induction of long-term synaptic facilitation and long-term memory in Aplysia","volume":"37","author":"Purcell","year":"2003","journal-title":"Neuron."},{"issue":"8","key":"10.1016\/j.phrs.2020.105078_bib0355","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1038\/sj.npp.1300440","article-title":"Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat Hippocampus","volume":"29","author":"Zhang","year":"2004","journal-title":"Neuropsychopharmacol"},{"issue":"41","key":"10.1016\/j.phrs.2020.105078_bib0360","doi-asserted-by":"crossref","first-page":"31921","DOI":"10.1074\/jbc.M003327200","article-title":"Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins","volume":"275","author":"Qiu","year":"2000","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0365","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/emboj\/18.4.893","article-title":"The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579","volume":"18","author":"Hoffmann","year":"1999","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0370","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0896-6273(01)00443-3","article-title":"Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase","volume":"32","author":"Patterson","year":"2001","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0375","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0962-8924(02)02294-8","article-title":"Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation","volume":"12","author":"Stork","year":"2002","journal-title":"Trends Cell Biol."},{"issue":"10","key":"10.1016\/j.phrs.2020.105078_bib0380","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nrm2509","article-title":"The RSK family of kinases: emerging roles in cellular signalling","volume":"9","author":"Anjum","year":"2008","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0385","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.neuron.2004.10.030","article-title":"Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo","volume":"44","author":"Gao","year":"2004","journal-title":"Neuron."},{"issue":"38","key":"10.1016\/j.phrs.2020.105078_bib0390","doi-asserted-by":"crossref","first-page":"15437","DOI":"10.1073\/pnas.1311783110","article-title":"ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion","volume":"110","author":"Song","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib0395","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1254\/jphs.CPJ06007X","article-title":"Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus","volume":"100","author":"Miyamoto","year":"2006","journal-title":"J Pharmacol Sci"},{"issue":"46","key":"10.1016\/j.phrs.2020.105078_bib0400","doi-asserted-by":"crossref","first-page":"10664","DOI":"10.1523\/JNEUROSCI.2443-05.2005","article-title":"Mitogen-activated protein kinase-mediated reinforcement of hippocampal early long-term depression by the type IV-specific phosphodiesterase inhibitor rolipram and its effect on synaptic tagging","volume":"25","author":"Navakkode","year":"2005","journal-title":"J Neurosci"},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib0405","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuint.2008.07.007","article-title":"NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway","volume":"53","author":"Valera","year":"2008","journal-title":"Neurochem Int."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0410","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1172\/JCI118049","article-title":"Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells","volume":"96","author":"Matousovic","year":"1995","journal-title":"J Clin Invest."},{"issue":"35","key":"10.1016\/j.phrs.2020.105078_bib0415","doi-asserted-by":"crossref","first-page":"23564","DOI":"10.1074\/jbc.M109.027821","article-title":"ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells","volume":"284","author":"Obara","year":"2009","journal-title":"J Biol Chem."},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib0420","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nrneurol.2013.222","article-title":"Brain repair after stroke--a novel neurological model","volume":"9","author":"Small","year":"2013","journal-title":"Nat Rev Neurol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0425","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1474-4422(12)70039-X","article-title":"Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation","volume":"11","author":"Hermann","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.phrs.2020.105078_bib0430","first-page":"11","article-title":"Neuroplastic changes following brain ischemia and their contribution to stroke recovery: novel approaches in Neurorehabilitation","author":"Alia","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.phrs.2020.105078_bib0435","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.nlm.2014.10.011","article-title":"PDE and cognitive processing: beyond the memory domain","volume":"119","author":"Heckman","year":"2015","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0440","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.npp.1301574","article-title":"Stress, depression, and neuroplasticity: a convergence of mechanisms","volume":"33","author":"Pittenger","year":"2008","journal-title":"Neuropsychopharmacology."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0445","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brs.2014.08.006","article-title":"Val66Met BDNF gene polymorphism influences human motor cortex plasticity in acute stroke","volume":"8","author":"Di Lazzaro","year":"2015","journal-title":"Brain Stimul"},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0450","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.pjnns.2017.02.008","article-title":"The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients","volume":"51","author":"Kotl\u0119ga","year":"2017","journal-title":"Neurol Neurochir Pol"},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib0455","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2522\/ptj.20130053","article-title":"Promoting neuroplasticity for motor rehabilitation after stroke: considering the effects of aerobic exercise and genetic variation on brain-derived neurotrophic factor","volume":"93","author":"Mang","year":"2013","journal-title":"Phys Ther."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0460","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/syn.20459","article-title":"Differential distribution of PDE4B splice variant mRNAs in rat brain and the effects of systemic administration of LPS in their expression","volume":"62","author":"Reyes-Irisarri","year":"2008","journal-title":"Synapse"},{"key":"10.1016\/j.phrs.2020.105078_bib0465","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13424","article-title":"Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1","volume":"5","author":"Havekes","year":"2016","journal-title":"eLife"},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib0470","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/sj.npp.1301537","article-title":"Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)","volume":"33","author":"Zhang","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105078_bib0475","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jns.2015.11.010","article-title":"Phosphodiesterase4D (PDE4D)--A risk factor for atrial fibrillation and stroke?","volume":"359","author":"J\u00f8rgensen","year":"2015","journal-title":"J Neurol Sci"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0480","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1124\/jpet.116.239608","article-title":"Novel phosphodiesterase 4 inhibitor FCPR03 alleviates lipopolysaccharide-induced neuroinflammation by regulation of the cAMP\/PKA\/CREB signaling pathway and NF-\u03baB inhibition","volume":"362","author":"Zou","year":"2017","journal-title":"J Pharmacol Exp Ther."},{"issue":"34","key":"10.1016\/j.phrs.2020.105078_bib0485","doi-asserted-by":"crossref","first-page":"8936","DOI":"10.1523\/JNEUROSCI.0248-16.2016","article-title":"Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory","volume":"36","author":"Havekes","year":"2016","journal-title":"J Neurosci"},{"key":"10.1016\/j.phrs.2020.105078_bib0490","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.expneurol.2017.03.025","article-title":"Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast","volume":"293","author":"Vogel","year":"2017","journal-title":"Exp Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0495","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1523\/JNEUROSCI.5236-10.2011","article-title":"Phosphodiesterase-4D knockout and RNAi-mediated knockdown enhance memory and increase hippocampal neurogenesis via increased cAMP signaling","volume":"31","author":"Li","year":"2011","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0500","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3233\/JAD-122236","article-title":"RNA interference-mediated knockdown of long-form phosphodiesterase-4D (PDE4D) enzyme reverses amyloid-\u03b242-induced memory deficits in mice","volume":"38","author":"Zhang","year":"2014","journal-title":"J Alzheimers Dis."},{"key":"10.1016\/j.phrs.2020.105078_bib0505","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuropharm.2017.01.004","article-title":"FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP\/PS1 transgenic mice via cAMP\/PKA\/CREB signaling and anti-inflammatory effects","volume":"116","author":"Guo","year":"2017","journal-title":"Neuropharmacology."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0510","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1038\/tp.2012.17","article-title":"PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosis","volume":"2","author":"Wiescholleck","year":"2012","journal-title":"Transl Psychiatry."},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib0515","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.euroneuro.2007.08.002","article-title":"Phosphodiesterase 10A inhibition is associated with locomotor and cognitive deficits and increased anxiety in mice","volume":"18","author":"Hebb","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"issue":"191","key":"10.1016\/j.phrs.2020.105078_bib0520","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-3-540-68964-5_5","article-title":"Phosphodiesterases in the central nervous system","author":"Kleppisch","year":"2009","journal-title":"Handb Exp Pharmacol"},{"issue":"10043","key":"10.1016\/j.phrs.2020.105078_bib0525","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer\u2019s disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0530","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pharep.2014.09.004","article-title":"A review on Alzheimer\u2019s disease pathophysiology and its management: an update","volume":"67","author":"Kumar","year":"2015","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.phrs.2020.105078_bib0535","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fchem.2018.00178","article-title":"Highlights in BACE1 inhibitors for alzheimer\u2019s disease treatment","volume":"6","author":"Coimbra","year":"2018","journal-title":"Front Chem"},{"key":"10.1016\/j.phrs.2020.105078_bib0540","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pnpbp.2019.01.005","article-title":"Dendritic spines: revisiting the physiological role","volume":"92","author":"Chidambaram","year":"2019","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.phrs.2020.105078_bib0545","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1093\/brain\/awt088","article-title":"The influence of phospho-\u03c4 on dendritic spines of cortical pyramidal neurons in patients with Alzheimer\u2019s disease","volume":"136","author":"Merino-Serrais","year":"2013","journal-title":"Brain"},{"issue":"2\u20133","key":"10.1016\/j.phrs.2020.105078_bib0550","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0014-5793(03)00645-8","article-title":"Inhibition of Abeta production and APP maturation by a specific PKA inhibitor","volume":"546","author":"Su","year":"2003","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0555","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0014-4886(03)00042-6","article-title":"Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer\u2019s disease brains examined by in situ hybridization","volume":"182","author":"P\u00e9rez-Torres","year":"2003","journal-title":"Exp Neurol"},{"issue":"13","key":"10.1016\/j.phrs.2020.105078_bib0560","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1073\/pnas.1322360111","article-title":"cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex","volume":"111","author":"Carlyle","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0565","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0006-8993(98)01307-9","article-title":"A quantitative autoradiographic study of [3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer\u2019s disease neurofibrillary changes and amyloid deposits","volume":"818","author":"Bonkale","year":"1999","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105078_bib0570","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0006-8993(99)02111-3","article-title":"Quantitative autoradiography of [3H]forskolin binding sites in post-mortem brain staged for Alzheimer\u2019s disease neurofibrillary changes and amyloid deposits","volume":"850","author":"Garc\u00eda-Jim\u00e9nez","year":"1999","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0575","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1111\/j.1471-4159.2007.04942.x","article-title":"Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain","volume":"103","author":"Liang","year":"2007","journal-title":"J Neurochem"},{"issue":"11","key":"10.1016\/j.phrs.2020.105078_bib0580","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1172\/JCI22831","article-title":"Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment","volume":"114","author":"Gong","year":"2004","journal-title":"J Clin Invest"},{"issue":"39","key":"10.1016\/j.phrs.2020.105078_bib0585","doi-asserted-by":"crossref","first-page":"16877","DOI":"10.1073\/pnas.0908706106","article-title":"Reversal of long-term dendritic spine alterations in Alzheimer disease models","volume":"106","author":"Smith","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0590","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1017\/S1461145711000836","article-title":"The phosphodiesterase-4 inhibitor rolipram reverses A\u03b2-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats","volume":"15","author":"Wang","year":"2012","journal-title":"Int. J. Neuropsychopharmacol"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0595","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nm.4011","article-title":"Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling","volume":"22","author":"Myeku","year":"2016","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.phrs.2020.105078_bib0600","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1111\/j.1476-5381.2011.01524.x","article-title":"GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses","volume":"164","author":"Bruno","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib0605","doi-asserted-by":"crossref","first-page":"e102449","DOI":"10.1371\/journal.pone.0102449","article-title":"Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female Cynomolgus monkeys (Macaca fascicularis)","volume":"9","author":"Sutcliffe","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.phrs.2020.105078_bib0610","first-page":"1","article-title":"Cocoa beans improve mitochondrial biogenesis via PPAR\u03b3\/PGC1\u03b1 dependent signalling pathway in MPP+ intoxicated human neuroblastoma cells (SH-SY5Y)","author":"Chidambaram","year":"2018","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.phrs.2020.105078_bib0615","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Disease Primers"},{"key":"10.1016\/j.phrs.2020.105078_bib0620","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuropharm.2013.05.025","article-title":"Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of \u03b1-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL\/6J mice","volume":"73","author":"Sathiya","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2020.105078_bib0625","first-page":"97","article-title":"Telmisartan alleviates nitrosative stress in turn dopaminergic degeneration in mice mptp model of parkinsonism \u201cbiochemical and histopathological evidences","volume":"1","author":"Sathiya","year":"2015","journal-title":"IJPPS"},{"key":"10.1016\/j.phrs.2020.105078_bib0630","doi-asserted-by":"crossref","DOI":"10.1007\/s12640-018-9921-3","article-title":"Telmisartan ameliorates astroglial and dopaminergic functions in a mouse model of chronic parkinsonism","author":"Sekar","year":"2018","journal-title":"Neurotox Res"},{"issue":"10","key":"10.1016\/j.phrs.2020.105078_bib0635","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyw030","article-title":"Phosphodiesterase inhibition and regulation of dopaminergic frontal and striatal functioning: clinical implications","volume":"19","author":"Heckman","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0640","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1515\/REVNEURO.1993.4.2.213","article-title":"Transmembrane signalling systems in the brain of patients with Parkinson\u2019s disease","volume":"4","author":"Nishino","year":"1993","journal-title":"Rev Neurosci"},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0645","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuint.2013.06.005","article-title":"Biomarkers in Parkinson\u2019s disease (recent update)","volume":"63","author":"Sharma","year":"2013","journal-title":"Neurochemistry International."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0650","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neuropharm.2003.09.009","article-title":"Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia","volume":"46","author":"Mizuno","year":"2004","journal-title":"Neuropharmacology."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0655","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jphs.2017.04.002","article-title":"Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson\u2019s disease","volume":"134","author":"Kinoshita","year":"2017","journal-title":"J. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0660","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1212\/WNL.0000000000004201","article-title":"Loss of phosphodiesterase 4 in Parkinson disease: relevance to cognitive deficits","volume":"89","author":"Niccolini","year":"2017","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib0665","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182019","article-title":"The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson\u2019s disease","volume":"12","author":"Schwenkgrub","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2020.105078_bib0670","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.redox.2018.02.008","article-title":"Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP+-induced decline of mitochondrial membrane potential and oxidative stress","volume":"16","author":"Zhong","year":"2018","journal-title":"Redox Biology"},{"key":"10.1016\/j.phrs.2020.105078_bib0675","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2019.02.027","article-title":"Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult","volume":"135","author":"Zhong","year":"2019","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib0680","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1111\/j.1460-9568.1995.tb01041.x","article-title":"Inhibitors of type IV phosphodiesterases reduce the toxicity of MPTP in substantia nigra neurons in vivo","volume":"7","author":"Hulley","year":"1995","journal-title":"Eur J Neurosci"},{"issue":"42","key":"10.1016\/j.phrs.2020.105078_bib0685","doi-asserted-by":"crossref","first-page":"10460","DOI":"10.1523\/JNEUROSCI.2518-08.2008","article-title":"Distinct roles of PDE4 and PDE10A in the regulation of cAMP\/PKA signaling in the striatum","volume":"28","author":"Nishi","year":"2008","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0690","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0031-6989(83)80017-4","article-title":"Therapeutic use of a selective cAMP phosphodiesterase inhibitor (Rolipram) in Parkinson\u2019s disease","volume":"15","author":"Casacchia","year":"1983","journal-title":"Pharmacol Res Commun."},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0695","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/sj.bjp.0704146","article-title":"Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model","volume":"133","author":"Takuma","year":"2001","journal-title":". Br J Pharmacol"},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0700","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/acn3.199","article-title":"Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis","volume":"2","author":"Salou","year":"2015","journal-title":"Ann Clin Transl Neurol."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105078_bib0705","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneuroim.2005.11.016","article-title":"IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination","volume":"173","author":"Deshpande","year":"2006","journal-title":"J Neuroimmunol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0710","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/01616412.2017.1420522","article-title":"Circulating levels of interleukin-17A, tumor necrosis factor-alpha, interleukin-18, interleukin-10, and cognitive performance of patients with relapsing-remitting multiple sclerosis","volume":"40","author":"Trenova","year":"2018","journal-title":"Neurol Res"},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib0715","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/jnr.24114","article-title":"Myelin as an inflammatory mediator: myelin interactions with complement, macrophages, and microglia in spinal cord injury","volume":"96","author":"Kopper","year":"2018","journal-title":"J Neurosci Res."},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib0720","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/07853890701379700","article-title":"Regulatory T cells--the renaissance of the suppressor T cells","volume":"39","author":"Bopp","year":"2007","journal-title":"Ann Med"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0725","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00313327","article-title":"Cyclic adenosine 3\u2032,5\u2032monophosphate in cerebrospinal fluid of multiple sclerosis patients","volume":"225","author":"Maida","year":"1981","journal-title":"J Neurol"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0730","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12031-013-9959-x","article-title":"Dibutyryl cyclic AMP inhibits the progression of experimental autoimmune encephalomyelitis and potentiates recruitment of endogenous neural stem cells","volume":"51","author":"Khezri","year":"2013","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.phrs.2020.105078_bib0735","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jneuroim.2018.06.002","article-title":"Sildenafil ameliorates EAE by decreasing apoptosis in the spinal cord of C57BL\/6 mice","volume":"321","author":"Duarte-Silva","year":"2018","journal-title":"Journal of Neuroimmunology"},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib0740","doi-asserted-by":"crossref","first-page":"43545","DOI":"10.1038\/srep43545","article-title":"Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis","volume":"03","author":"Medina-Rodr\u00edguez","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0745","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.4049\/jimmunol.159.3.1520","article-title":"Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein","volume":"159","author":"Ekholm","year":"1997","journal-title":"The Journal of Immunology."},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib0750","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/bph.12189","article-title":"Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1","volume":"169","author":"Korhonen","year":"2013","journal-title":"Br J Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0755","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/bph.12308","article-title":"Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis","volume":"170","author":"Gonz\u00e1lez-Garc\u00eda","year":"2013","journal-title":"Br J Pharmacol"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105078_bib0760","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-5728(96)00051-3","article-title":"Preventive but not therapeutic application of Rolipram ameliorates experimental autoimmune encephalomyelitis in Lewis rats","volume":"68","author":"Jung","year":"1996","journal-title":"J Neuroimmunol."},{"issue":"8","key":"10.1016\/j.phrs.2020.105078_bib0765","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1073\/pnas.92.8.3601","article-title":"Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor","volume":"92","author":"Genain","year":"1995","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105078_bib0770","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0165-5728(98)00251-3","article-title":"A phosphodiesterase inhibitor, ameliorates experimental autoimmune encephalomyelitis in Dark August rats","volume":"95","author":"Fujimoto","year":"1999","journal-title":"J Neuroimmunol"},{"issue":"97","key":"10.1016\/j.phrs.2020.105078_bib0775","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-5728(99)00063-6","article-title":"Treatment with BBB022A or rolipram stabilizes the blood-brain barrier in experimental autoimmune encephalomyelitis: an additional mechanism for the therapeutic effect of type IV phosphodiesterase inhibitors","volume":"1","author":"Folcik","year":"1999","journal-title":"J Neuroimmunol."},{"key":"10.1016\/j.phrs.2020.105078_bib0780","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/978-3-319-58811-7_14","article-title":"PDE inhibitors for the treatment of schizophrenia","volume":"17","author":"Snyder","year":"2017","journal-title":"Adv Neurobiol"},{"issue":"26","key":"10.1016\/j.phrs.2020.105078_bib0785","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.2174\/1381612821666150605110941","article-title":"Treatment of cognitive impairment in schizophrenia: potential value of phosphodiesterase inhibitors in prefrontal dysfunction","volume":"21","author":"Duinen","year":"2015","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.phrs.2020.105078_bib0790","article-title":"An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients","author":"Gilleen","year":"2018","journal-title":"Psychopharmacology"},{"issue":"5751","key":"10.1016\/j.phrs.2020.105078_bib0795","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1126\/science.1112915","article-title":"DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling","volume":"310","author":"Millar","year":"2005","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0800","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/YPG.0b013e328014492b","article-title":"The PDE4B gene confers sex-specific protection against schizophrenia","volume":"17","author":"Pickard","year":"2007","journal-title":"Psychiatr Genet"},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0805","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.bbrc.2008.10.120","article-title":"DISC1, PDE4B, and NDE1 at the centrosome and synapse","volume":"377","author":"Bradshaw","year":"2008","journal-title":"Biochem Biophys Res Commun."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0810","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neuron.2007.04.015","article-title":"Behavioral phenotypes of Disc1 missense mutations in mice","volume":"54","author":"Clapcote","year":"2007","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0815","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.neuropharm.2006.04.013","article-title":"Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis","volume":"51","author":"Siuciak","year":"2006","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0820","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0021-5198(19)30605-5","article-title":"Effects of rolipram, a selective inhibitor of phosphodiesterase 4, on hyperlocomotion induced by several abused drugs in mice","volume":"83","author":"Mori","year":"2000","journal-title":"Jpn J Pharmacol"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0825","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroscience.2006.09.026","article-title":"Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity","volume":"144","author":"Kanes","year":"2007","journal-title":"Neuroscience"},{"issue":"10161","key":"10.1016\/j.phrs.2020.105078_bib0830","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"The Lancet"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105078_bib0835","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0006-8993(94)91552-0","article-title":"Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims","volume":"633","author":"Cowburn","year":"1994","journal-title":"Brain Res."},{"issue":"9142","key":"10.1016\/j.phrs.2020.105078_bib0840","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/S0140-6736(05)79827-5","article-title":"Increased temporal cortex CREB concentrations and antidepressant treatment in major depression","volume":"352","author":"Dowlatshahi","year":"1998","journal-title":"Lancet."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0845","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1176\/appi.ajp.159.1.66","article-title":"[(3)H]cAMP binding sites and protein kinase a activity in the prefrontal cortex of suicide victims","volume":"159","author":"Dwivedi","year":"2002","journal-title":"Am J Psychiatry."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0850","first-page":"46","article-title":"Involvement of beta-1 and beta-2 adrenergic receptors in the antidepressant-like effects of centrally administered isoproterenol","volume":"271","author":"O\u2019Donnell","year":"1994","journal-title":"J Pharmacol Exp Ther."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0855","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s002130100889","article-title":"Comparison of the effects of isoproterenol administered into the hippocampus, frontal cortex, or amygdala on behavior of rats maintained by differential reinforcement of low response rate","volume":"159","author":"Zhang","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0860","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/phrs.1999.0609","article-title":"Evidence for different interactions between beta(1)- and beta(2)-adrenoceptor subtypes with adenylyl cyclase in the rat brain: a concentration-response study using forskolin","volume":"41","author":"Morin","year":"2000","journal-title":"Pharmacol Res."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0865","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/sj.emboj.7601968","article-title":"Signaling from \u03b21- and \u03b22-adrenergic receptors is defined by differential interactions with PDE4","volume":"27","author":"Richter","year":"2008","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0870","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00213-005-0055-y","article-title":"Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor rolipram in rats","volume":"182","author":"Zhang","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib0875","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/mp.2016.171","article-title":"cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor","volume":"22","author":"Fujita","year":"2017","journal-title":"Mol Psychiatry."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0880","first-page":"132","article-title":"Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on \u03b3:-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress","volume":"3","author":"Shalaby","year":"2012","journal-title":"Journal of Pharmacology and Pharmacotherapeutics."},{"key":"10.1016\/j.phrs.2020.105078_bib0885","doi-asserted-by":"crossref","first-page":"11332","DOI":"10.1038\/srep11332","article-title":"Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice","volume":"5","author":"Wang","year":"2015","journal-title":"Scientific Reports"},{"key":"10.1016\/j.phrs.2020.105078_bib0890","doi-asserted-by":"crossref","first-page":"40115","DOI":"10.1038\/srep40115","article-title":"Comparison of the pharmacological profiles of selective PDE4B and PDE4D inhibitors in the central nervous system","volume":"7","author":"Zhang","year":"2017","journal-title":"Scientific Reports."},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib0895","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1161\/STROKEAHA.106.476754","article-title":"The phosphodiesterase inhibitor rolipram promotes survival of newborn hippocampal neurons after ischemia","volume":"38","author":"Sasaki","year":"2007","journal-title":"Stroke."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0900","first-page":"41","article-title":"Phoenix dactylifera L. Fruits date fruit ameliorate oxidative stress in 3-NP intoxicated PC12 cells","volume":"9","author":"Essa","year":"2019","journal-title":"Int. J. Nutrition Pharmacol. Neurol. Diseases."},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib0905","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177610","article-title":"Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation","volume":"12","author":"Xu","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0910","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0278-5846(03)00021-6","article-title":"Apoptosis in Huntington\u2019s disease","volume":"27","author":"Hickey","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"5\u20136","key":"10.1016\/j.phrs.2020.105078_bib0915","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","article-title":"Role of brain-derived neurotrophic factor in Huntington\u2019s disease","volume":"81","author":"Zuccato","year":"2007","journal-title":"Prog Neurobiol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib0920","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.nbd.2008.02.010","article-title":"Beneficial effects of rolipram in the R6\/2 mouse model of Huntington\u2019s disease","volume":"30","author":"DeMarch","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.phrs.2020.105078_bib0925","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-3-319-58811-7_11","article-title":"Role of phosphodiesterases in Huntington\u2019s disease","volume":"17","author":"Fusco","year":"2017","journal-title":"Adv Neurobiol."},{"key":"10.1016\/j.phrs.2020.105078_bib0930","first-page":"1","article-title":"Anatomy and pathophysiology of stroke","volume":"2","author":"Auriel","year":"2009","journal-title":"Stroke."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0935","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijdevneu.2010.08.001","article-title":"Post-ischemic administration of nimodipine following focal cerebral ischemic-reperfusion injury in rats alleviated excitotoxicity, neurobehavioural alterations and partially the bioenergetics","volume":"29","author":"Babu","year":"2011","journal-title":"Int J Dev Neurosci"},{"issue":"10","key":"10.1016\/j.phrs.2020.105078_bib0940","doi-asserted-by":"crossref","first-page":"577","DOI":"10.33588\/rn.4410.2006521","article-title":"Prognostic factors of functional recovery in very elderly stroke patients. A one-year follow-up study","volume":"44","author":"Bazt\u00e1n","year":"2007","journal-title":"Rev Neurol."},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib0945","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.7150\/ijbs.26230","article-title":"Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke","volume":"14","author":"Wang","year":"2018","journal-title":"Int J Biol Sci."},{"issue":"17","key":"10.1016\/j.phrs.2020.105078_bib0950","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1097\/00001756-199712010-00033","article-title":"Delayed treatment with rolipram protects against neuronal damage following global ischemia in rats","volume":"8","author":"Block","year":"1997","journal-title":"Neuroreport"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib0955","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-2999(94)00694-3","article-title":"Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil","volume":"272","author":"Kato","year":"1995","journal-title":"Eur J Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib0960","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/STROKEAHA.118.023664","article-title":"Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function","volume":"50","author":"Bieber","year":"2019","journal-title":"Stroke."},{"issue":"23","key":"10.1016\/j.phrs.2020.105078_bib0965","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1073\/pnas.0402595101","article-title":"The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery","volume":"101","author":"Nikulina","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2020.105078_bib0970","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.expneurol.2013.03.026","article-title":"The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis","volume":"247","author":"Kraft","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1016\/j.phrs.2020.105078_bib0975","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/21678421.2013.778554","article-title":"Mechanisms, models and biomarkers in amyotrophic lateral sclerosis","volume":"14","author":"Turner","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"51","key":"10.1016\/j.phrs.2020.105078_bib0980","doi-asserted-by":"crossref","first-page":"40266","DOI":"10.1074\/jbc.M110.161398","article-title":"Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis","volume":"285","author":"Chen","year":"2010","journal-title":"J Biol Chem"},{"issue":"5870","key":"10.1016\/j.phrs.2020.105078_bib0985","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science."},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib0990","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1046\/j.1471-4159.2001.00498.x","article-title":"Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection","volume":"78","author":"Guillemin","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2020.105078_bib0995","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.neuropharm.2016.05.011","article-title":"Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis","volume":"112","author":"Lee","year":"2017","journal-title":"Neuropharmacology."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1000","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3390\/jcm9010261","article-title":"Glial cells\u2014the strategic targets in amyotrophic lateral sclerosis treatment","volume":"9","author":"Filipi","year":"2020","journal-title":"J Clin Med."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbrc.2020.03.051","article-title":"Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: The new molecular mechanism of ibudilast and its implication for neuroprotective therapy","volume":"526","author":"Chen","year":"2020","journal-title":"Biochem Biophys Res Commun."},{"issue":"6\u20137","key":"10.1016\/j.phrs.2020.105078_bib1010","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1440-1681.1996.tb02772.x","article-title":"Ibudilast protects against neuronal damage induced by glutamate in cultured hippocampal neurons","volume":"23","author":"Tominaga","year":"1996","journal-title":"Clin Exp Pharmacol Physiol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1015","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1471-4159.2000.740633.x","article-title":"Cyclic GMP\/cyclic GMP-dependent protein kinase system prevents excitotoxicity in an immortalized oligodendroglial cell line","volume":"74","author":"Yoshioka","year":"2000","journal-title":"J Neurochem"},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib1020","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3171\/jns.1977.46.4.0477","article-title":"Cyclic AMP and adenyl cyclase in brain tumors","volume":"46","author":"Furman","year":"1977","journal-title":"J Neurosurg."},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib1025","doi-asserted-by":"crossref","first-page":"e2494","DOI":"10.1038\/cddis.2016.393","article-title":"Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling","volume":"7","author":"Daniel","year":"2016","journal-title":"Cell Death & Disease."},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib1030","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.celrep.2018.04.016","article-title":"CDK5 inhibition resolves PKA\/cAMP-Independent activation of CREB1 signaling in glioma stem cells","volume":"23","author":"Mukherjee","year":"2018","journal-title":"Cell Rep"},{"issue":"11","key":"10.1016\/j.phrs.2020.105078_bib1035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178881","article-title":"Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma","volume":"12","author":"Oh","year":"2017","journal-title":"PLoS ONE"},{"issue":"39","key":"10.1016\/j.phrs.2020.105078_bib1040","doi-asserted-by":"crossref","first-page":"15805","DOI":"10.1073\/pnas.1207787109","article-title":"cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a","volume":"109","author":"Tan","year":"2012","journal-title":"PNAS"},{"issue":"23","key":"10.1016\/j.phrs.2020.105078_bib1045","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1158\/1078-0432.CCR-08-0827","article-title":"Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression","volume":"14","author":"Goldhoff","year":"2008","journal-title":"Clin Cancer Res."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10549-015-3445-9","article-title":"Inhibition of breast cancer cell migration by activation of cAMP signaling","volume":"152","author":"Dong","year":"2015","journal-title":"Breast Cancer Res Treat."},{"issue":"9","key":"10.1016\/j.phrs.2020.105078_bib1055","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrm1197","article-title":"Epac: a new cAMP target and new avenues in cAMP research","volume":"4","author":"Bos","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol"},{"issue":"10","key":"10.1016\/j.phrs.2020.105078_bib1060","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1182\/blood-2002-10-3208","article-title":"PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A","volume":"101","author":"Moon","year":"2003","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib1065","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4161\/cbt.80","article-title":"The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells","volume":"1","author":"Chen","year":"2002","journal-title":"Cancer Biol Ther"},{"issue":"9\u201310","key":"10.1016\/j.phrs.2020.105078_bib1070","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.lfs.2011.12.010","article-title":"Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1\/Rap1 pathways","volume":"90","author":"Moon","year":"2012","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib1075","doi-asserted-by":"crossref","first-page":"325","DOI":"10.18869\/nirp.bcn.8.4.325","article-title":"The role of protein kinase B signaling pathway in anti-cancer effect of rolipram on glioblastoma multiforme: an in vitro study","volume":"8","author":"Ramezani","year":"2017","journal-title":"Basic Clinical Neurosci."},{"issue":"23","key":"10.1016\/j.phrs.2020.105078_bib1080","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1158\/1078-0432.CCR-08-0827","article-title":"CCR-08-0827 Version 2 targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression","volume":"14","author":"Goldhoff","year":"2008","journal-title":"Clin Cancer Res."},{"key":"10.1016\/j.phrs.2020.105078_bib1085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.lfs.2017.02.005","article-title":"Rolipram potentiates bevacizumab-induced cell death in human glioblastoma stem-like cells","volume":"173","author":"Ramezani","year":"2017","journal-title":"Life Sci"},{"key":"10.1016\/j.phrs.2020.105078_bib1090","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1038\/srep05546","article-title":"Growth arrest and forced differentiation of human primary glioblastoma multiforme by a novel small molecule","volume":"4","author":"Kang","year":"2014","journal-title":"Sci Rep."},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib1095","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1523\/JNEUROSCI.5133-12.2013","article-title":"Phosphodiesterase inhibition rescues chronic cognitive deficits induced by traumatic brain injury","volume":"33","author":"Titus","year":"2013","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib1100","first-page":"1307","article-title":"The pathophysiology of traumatic brain injury at a glance","volume":"6","author":"Prins","year":"2013","journal-title":"Dis Model Mech."},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib1105","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/jnc.12049","article-title":"Phosphodiesterase isoform-specific expression induced by traumatic brain injury","volume":"123","author":"Oliva","year":"2012","journal-title":"J Neurochem"},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib1110","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1038\/sj.bjp.0704629","article-title":"Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats","volume":"135","author":"Nagakura","year":"2002","journal-title":"Br J Pharmacol."},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib1115","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1002\/glia.22401","article-title":"Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury","volume":"60","author":"Ghosh","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.phrs.2020.105078_bib1120","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2016.00005","article-title":"Traumatic brain injury upregulates phosphodiesterase expression in the Hippocampus","volume":"10","author":"Wilson","year":"2016","journal-title":"Frontiers in Systems Neuroscience"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11011-011-9235-0","article-title":"Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats","volume":"26","author":"Li","year":"2011","journal-title":"Metab Brain Dis."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1130","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.expneurol.2007.08.011","article-title":"Modulation of the cAMP signaling pathway after traumatic brain injury","volume":"208","author":"Atkins","year":"2007","journal-title":"Exp Neurol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105078_bib1135","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association\/american stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"issue":"10004","key":"10.1016\/j.phrs.2020.105078_bib1140","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O\u2019Brien","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2020.105078_bib1145","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1749-6632.2000.tb06351.x","article-title":"Role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in Alzheimer\u2019s disease","volume":"903","author":"de la Monte","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.phrs.2020.105078_bib1150","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejphar.2018.05.015","article-title":"Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP\/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO induced vascular dementia in rats","volume":"832","author":"Kaundal","year":"2018","journal-title":"Eur J Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s13311-014-0309-7","article-title":"Phosphodiesterase-4 (PDE4) molecular pharmacology and alzheimer\u2019s disease","volume":"12","author":"Gurney","year":"2015","journal-title":"Neurotherapeutics"},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib1160","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/01.STR.20.5.668","article-title":"Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia","volume":"20","author":"Tanaka","year":"1989","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.phrs.2020.105078_bib1165","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1038\/npp.2009.24","article-title":"Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats","volume":"34","author":"Rutten","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2020.105078_bib1170","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.neuropharm.2018.06.019","article-title":"Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion","volume":"138","author":"Santiago","year":"2018","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib1175","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1021\/acs.jmedchem.0c00060","article-title":"Discovery and optimization of \u03b1-Mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia","volume":"63","author":"Liang","year":"2020","journal-title":"Journal of Medicinal Chemistry"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105078_bib1180","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000118897","article-title":"A multicenter double-blind study of three different doses of the new cAMP-phosphodiesterase inhibitor rolipram in patients with major depressive disorder","volume":"26","author":"Fleischhacker","year":"1992","journal-title":"Neuropsychobiology"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1185","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/sj.bjp.0704457","article-title":"Assessing the emetic potential of PDE4 inhibitors in rats","volume":"135","author":"Robichaud","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.phrs.2020.105078_bib1190","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.biopha.2017.01.059","article-title":"Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer\u2019s Type","volume":"88","author":"Kumar","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1195","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00429-017-1518-8","article-title":"Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata","volume":"23","author":"Heckman","year":"2018","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.phrs.2020.105078_bib1200","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuropharm.2017.12.019","article-title":"Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults","volume":"131","author":"Duinen","year":"2018","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib1205","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/hup.470030407","article-title":"A double-blind dose-finding study of rolipram in patients with major depressive disorder","volume":"3","author":"Bennie","year":"1988","journal-title":"Human Psychopharmacology: Clinical and Experimental"},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib1210","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/s-2007-1014599","article-title":"Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine","volume":"22","author":"Hebenstreit","year":"1989","journal-title":"Pharmacopsychiatry"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1215","first-page":"23","article-title":"Clinical effects of the neurotropic selective cAMP phosphodiesterase inhibitor rolipram in depressed patients: global evaluation of the preliminary reports","volume":"38","author":"Horowski","year":"1985","journal-title":"Current Therapeutic Research."},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib1220","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1055\/s-2007-1017435","article-title":"Results of a phase II study of the antidepressant effect of rolipram","volume":"17","author":"Zeller","year":"1984","journal-title":"Pharmacopsychiatry"},{"issue":"11","key":"10.1016\/j.phrs.2020.105078_bib1225","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1007\/s00018-005-4533-5","article-title":"Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development","volume":"62","author":"Jeon","year":"2005","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1230","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/pupt.1999.0181","article-title":"Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic","volume":"12","author":"Torphy","year":"1999","journal-title":"Pulm Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1235","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nbt.1598","article-title":"Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety","volume":"28","author":"Burgin","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib1240","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1172\/JCI0215506","article-title":"Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis","volume":"110","author":"Robichaud","year":"2002","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.phrs.2020.105078_bib1245","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1517\/13543770903313753","article-title":"PDE4 inhibitors: a review of current developments (2005 - 2009)","volume":"19","author":"Pag\u00e8s","year":"2009","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.phrs.2020.105078_bib1250","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nlm.2017.12.008","article-title":"A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury","volume":"148","author":"Titus","year":"2018","journal-title":"Neurobiol Learn Mem"},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib1255","doi-asserted-by":"crossref","first-page":"e102449","DOI":"10.1371\/journal.pone.0102449","article-title":"Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female Cynomolgus monkeys (Macaca fascicularis)","volume":"9","author":"Sutcliffe","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.phrs.2020.105078_bib1260","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1096\/fasebj.2019.33.1_supplement.806.4","article-title":"A selective phosphodiesterase 4D inhibitor BPN14770 reverses beta amyloid-induced memory impairment in humanized PDE4D mice","volume":"33","author":"Xu","year":"2019","journal-title":"The FASEB Journal."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1265","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1124\/jpet.301.1.241","article-title":"Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative, with anti-inflammatory activities","volume":"301","author":"Trifilieff","year":"2002","journal-title":"J Pharmacol Exp Ther."},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib1270","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0026-895X(24)12557-6","article-title":"Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10","volume":"59","author":"Rena","year":"2001","journal-title":"Mol Pharmacol"},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib1275","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1124\/mol.104.009423","article-title":"Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene","volume":"67","author":"Wallace","year":"2005","journal-title":"Mol Pharmacol"},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib1280","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/1759-7714.12475","article-title":"Epac1, PDE4, and PKC protein expression and their association with AKAP95, Cx43, and cyclinD2\/E1 in breast cancer tissues","volume":"8","author":"Huang","year":"2017","journal-title":"Thorac Cancer"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1285","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/BJ20071251","article-title":"Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change","volume":"411","author":"Mackenzie","year":"2008","journal-title":"Biochem J"},{"key":"10.1016\/j.phrs.2020.105078_bib1290","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1186\/s12885-016-2980-z","article-title":"Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia","volume":"16","author":"Mahmood","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.phrs.2020.105078_bib1295","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1042\/bj3330693","article-title":"Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2","volume":"333","author":"Sullivan","year":"1998","journal-title":"Biochem J."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1300","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1038\/s41598-018-22934-1","article-title":"Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission","volume":"8","author":"Agis-Torres","year":"2018","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1305","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/path.4760","article-title":"Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis","volume":"240","author":"Avila","year":"2016","journal-title":"J Pathol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1310","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0022-3565(24)36487-0","article-title":"The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy","volume":"280","author":"Cheng","year":"1997","journal-title":"J Pharmacol Exp Ther."},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1315","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.3390\/ijms16022320","article-title":"Cyclic nucleotide signalling in kidney fibrosis","volume":"16","author":"Schinner","year":"2015","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.phrs.2020.105078_bib1320","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/ncomms2674","article-title":"Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD","volume":"4","author":"Komatsu","year":"2013","journal-title":"Nature Communications"},{"issue":"10","key":"10.1016\/j.phrs.2020.105078_bib1325","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1002\/glia.22986","article-title":"PDE4B as a microglia target to reduce neuroinflammation","volume":"64","author":"Pearse","year":"2016","journal-title":"Glia."},{"issue":"6","key":"10.1016\/j.phrs.2020.105078_bib1330","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.jaci.2010.08.014","article-title":"Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma","volume":"126","author":"Jin","year":"2010","journal-title":"J Allergy Clin Immunol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib1335","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/pros.21478","article-title":"Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer","volume":"72","author":"Kashiwagi","year":"2012","journal-title":"Prostate"},{"key":"10.1016\/j.phrs.2020.105078_bib1340","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2016.00259","article-title":"Differential expression and function of PDE8 and PDE4 in effector t cells: implications for PDE8 as a drug target in inflammation","volume":"7","author":"Vang","year":"2016","journal-title":"Front Pharmacol"},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib1345","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1210\/en.2009-0108","article-title":"Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B","volume":"150","author":"Zhang","year":"2009","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1350","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1152\/ajpregu.00042.2018","article-title":"Phosphodiesterase 4B knockout prevents skeletal muscle atrophy in rats with burn injury","volume":"315","author":"Balasubramaniam","year":"2018","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"26","key":"10.1016\/j.phrs.2020.105078_bib1355","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.1016214108","article-title":"Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases","volume":"108","author":"Choi","year":"2011","journal-title":"Proc Natl Acad Sci USA."},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib1360","first-page":"1033","article-title":"PDE4B mediates local feedback regulation of \u03b21-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes","volume":"127","author":"Mika","year":"2014","journal-title":"J Cell Sci."},{"issue":"1","key":"10.1016\/j.phrs.2020.105078_bib1365","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1530\/REP-14-0436","article-title":"Phosphodiesterases in the rat ovary: effect of cAMP in primordial follicles","volume":"150","author":"Petersen","year":"2015","journal-title":"Reproduction"},{"issue":"14","key":"10.1016\/j.phrs.2020.105078_bib1370","first-page":"1800","article-title":"Cross-talk between PKA-C\u03b2 and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi","volume":"112","author":"Susuki","year":"2015","journal-title":"PNAS."},{"key":"10.1016\/j.phrs.2020.105078_bib1375","first-page":"111","article-title":"Alterations of phosphodiesterases in adrenocortical tumors","volume":"7","author":"Hannah","year":"2016","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1380","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1042\/CS20180519","article-title":"Creating a potential diagnostic for prostate cancer risk stratification (InformMDxTM) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7)","volume":"133","author":"Henderson","year":"2019","journal-title":"Clinical Science"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1385","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3892\/etm.2012.587","article-title":"Phosphodiesterase 4 regulates the migration of B16-F10 melanoma cells","volume":"4","author":"Watanabe","year":"2012","journal-title":"Exp Ther Med"},{"issue":"3","key":"10.1016\/j.phrs.2020.105078_bib1390","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0167-4781(97)00080-8","article-title":"Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis","volume":"1353","author":"Obernolte","year":"1997","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"10.1016\/j.phrs.2020.105078_bib1395","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.4049\/jimmunol.178.8.4820","article-title":"Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ t cells: predominant role of PDE4D","volume":"178","author":"Peter","year":"2007","journal-title":"The Journal of Immunology"},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib1400","doi-asserted-by":"crossref","first-page":"e14191","DOI":"10.1371\/journal.pone.0014191","article-title":"Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets","volume":"5","author":"Heimann","year":"2010","journal-title":"PLOS ONE"},{"issue":"2","key":"10.1016\/j.phrs.2020.105078_bib1405","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00395-010-0138-8","article-title":"Conserved expression and functions of PDE4 in rodent and human heart","volume":"106","author":"Richter","year":"2011","journal-title":"Basic Res Cardiol"},{"issue":"7","key":"10.1016\/j.phrs.2020.105078_bib1410","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.bcp.2008.07.025","article-title":"Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832\/13) cells and rat islets","volume":"76","author":"Waddleton","year":"2008","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib1415","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1194\/jlr.M600519-JLR200","article-title":"mRNA expression and antilipolytic role of phosphodiesterase 4 in rat adipocytes in vitro","volume":"48","author":"Wang","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1016\/j.phrs.2020.105078_bib1420","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1096\/fasebj.24.1_supplement.801.11","article-title":"The inhibition of phosphodiesterase 4 reduces skeletal muscle protein catabolism by suppressing autophagy\/lysosomal and proteasomal pathways and atrophy-specific gene transcription","volume":"24","author":"Lira","year":"2010","journal-title":"The FASEB Journal."},{"issue":"4","key":"10.1016\/j.phrs.2020.105078_bib1425","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.bbrc.2013.11.004","article-title":"Dynamic expression pattern of Pde4d and its relationship with CpG methylation in the promoter during mouse embryo development","volume":"441","author":"Huang","year":"2013","journal-title":"Biochem Biophys Res Commun."},{"issue":"5","key":"10.1016\/j.phrs.2020.105078_bib1430","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1095\/biolreprod.106.055343","article-title":"Expression of the cAMP-Phosphodiesterase PDE4D isoforms and age-related changes in follicle-stimulating hormone-stimulated PDE4 activities in immature rat sertoli cells","volume":"76","author":"Levallet","year":"2007","journal-title":"Biol Reprod"},{"issue":"17","key":"10.1016\/j.phrs.2020.105078_bib1435","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1016\/j.febslet.2006.06.058","article-title":"Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice","volume":"580","author":"Gr\u00f8nning","year":"2006","journal-title":"FEBS Letters"},{"issue":"15","key":"10.1016\/j.phrs.2020.105078_bib1440","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1073\/pnas.1218206110","article-title":"Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers","volume":"110","author":"Lin","year":"2013","journal-title":"PNAS"},{"issue":"8","key":"10.1016\/j.phrs.2020.105078_bib1445","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1158\/1078-0432.CCR-17-2776","article-title":"Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer","volume":"24","author":"Mishra","year":"2018","journal-title":"Clin Cancer Res"},{"issue":"Pt 3","key":"10.1016\/j.phrs.2020.105078_bib1450","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/BJ20050030","article-title":"Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue","volume":"388","author":"Richter","year":"2005","journal-title":"Biochem J."},{"issue":"12","key":"10.1016\/j.phrs.2020.105078_bib1455","doi-asserted-by":"crossref","first-page":"E1414","DOI":"10.1073\/pnas.1419906112","article-title":"Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4","volume":"112","author":"Cedervall","year":"2015","journal-title":"PNAS."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820313864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820313864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:13:19Z","timestamp":1760911999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661820313864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":291,"alternative-id":["S1043661820313864"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105078","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105078"}}