{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:41:53Z","timestamp":1789177313012,"version":"build-2803163510"},"reference-count":349,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NIH-NCI","award":["CA207287"],"award-info":[{"award-number":["CA207287"]}]},{"name":"WesternU intramural startup fund"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.phrs.2020.105124","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T10:27:14Z","timestamp":1597573634000},"page":"105124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"special_numbering":"C","title":["Dopamine receptors in emesis: Molecular mechanisms and potential therapeutic function"],"prefix":"10.1016","volume":"161","author":[{"given":"Louiza","family":"Belkacemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nissar A.","family":"Darmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.phrs.2020.105124_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/a2019934-b1cc-4781-80cb-9e09fc7ff6dc","article-title":"The dopamine metabolite 3-methoxytyramine is a neuromodulator","volume":"5","author":"Sotnikova","year":"2010","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib0010","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0028-3908(96)00100-1","article-title":"Dopamine receptors and brain function","volume":"35","author":"Jaber","year":"1996","journal-title":"Neuropharmacology"},{"issue":"24","key":"10.1016\/j.phrs.2020.105124_bib0015","doi-asserted-by":"crossref","first-page":"8506","DOI":"10.1523\/JNEUROSCI.23-24-08506.2003","article-title":"Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity","volume":"23","author":"Centonze","year":"2003","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib0020","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s10072-014-1996-x","article-title":"Dopamine agonist withdrawal syndrome in a patient with restless legs syndrome without impulse control disorder or drug abuse","volume":"36","author":"Shimo","year":"2015","journal-title":"Neurol. Sci."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0025","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.parkreldis.2012.06.006","article-title":"Dopamine agonist withdrawal syndrome in a patient with restless legs syndrome","volume":"19","author":"Dorfman","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib0030","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.3390\/ph3092930","article-title":"Mechanisms of broad-spectrum antiemetic efficacy of cannabinoids against chemotherapy-induced acute and delayed vomiting","volume":"3","author":"Darmani","year":"2010","journal-title":"Pharmaceuticals (Basel)"},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0035","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1021\/cr900117p","article-title":"Evidence for a re-evaluation of the neurochemical and anatomical bases of chemotherapy-induced vomiting","volume":"109","author":"Darmani","year":"2009","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0040","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","article-title":"Dopamine receptors: from structure to function","volume":"78","author":"Missale","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2020.105124_bib0045","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.neuro.27.070203.144206","article-title":"Desensitization of G protein-coupled receptors and neuronal functions","volume":"27","author":"Gainetdinov","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib0050","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1073\/pnas.0230374100","article-title":"The G protein-coupled receptor repertoires of human and mouse","volume":"100","author":"Vassilatis","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib0055","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0165-6147(90)90249-8","article-title":"Dopamine receptor subtypes: beyond the D1\/D2 classification","volume":"11","author":"Andersen","year":"1990","journal-title":"Trends Pharmacol. Sci."},{"issue":"1\u20134","key":"10.1016\/j.phrs.2020.105124_bib0060","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3109\/10799899309073679","article-title":"Dopaminergic activity measured in D1- and D2- transfected fibroblasts by silicon-microphysiometry","volume":"13","author":"Bouvier","year":"1993","journal-title":"J. Recept. Res."},{"issue":"1\u20133","key":"10.1016\/j.phrs.2020.105124_bib0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0014-2999(96)00061-1","article-title":"Involvement of dopamine D3 receptors in the area postrema in R(+)-7-OH-DPAT-induced emesis in the ferret","volume":"301","author":"Yoshikawa","year":"1996","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0070","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.pbb.2005.03.012","article-title":"Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets","volume":"81","author":"Osinski","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0075","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/0003-9861(70)90144-X","article-title":"Preparation and properties of a homogeneous aromatic L-amino acid decarboxylase from hog kidney","volume":"141","author":"Christenson","year":"1970","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0080","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0006-3002(56)90261-X","article-title":"Precursors of adrenal epinephrine and norepinephrine in vivo","volume":"20","author":"Udenfriend","year":"1956","journal-title":"Biochim. Biophys. Acta"},{"issue":"4016","key":"10.1016\/j.phrs.2020.105124_bib0085","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.174.4016.1349","article-title":"Proportional release of norepinephrine and dopamine- -hydroxylase from sympathetic nerves","volume":"174","author":"Weinshilboum","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.phrs.2020.105124_bib0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2014.01.025","article-title":"The role of D2-autoreceptors in regulating dopamine neuron activity and transmission","volume":"282","author":"Ford","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2020.105124_bib0095","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev.ne.16.030193.001503","article-title":"Recent advances in the molecular biology of dopamine receptors","volume":"16","author":"Gingrich","year":"1993","journal-title":"Annu. Rev. Neurosci."},{"issue":"6252","key":"10.1016\/j.phrs.2020.105124_bib0100","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/342923a0","article-title":"Alternative splicing directs the expression of two D2 dopamine receptor isoforms","volume":"342","author":"Giros","year":"1989","journal-title":"Nature"},{"issue":"6252","key":"10.1016\/j.phrs.2020.105124_bib0105","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/342926a0","article-title":"Multiple D2 dopamine receptors produced by alternative RNA splicing","volume":"342","author":"Monsma","year":"1989","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0110","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/0006-291X(91)90469-N","article-title":"Shorter variants of the D3 dopamine receptor produced through various patterns of alternative splicing","volume":"176","author":"Giros","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6319","key":"10.1016\/j.phrs.2020.105124_bib0115","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/350610a0","article-title":"Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine","volume":"350","author":"Van Tol","year":"1991","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0120","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0165-6147(94)90323-9","article-title":"Dopamine receptor pharmacology","volume":"15","author":"Seeman","year":"1994","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0125","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0022-3956(96)00039-8","article-title":"Review the role of dopamine D4 receptors in schizophrenia and antipsychotic action","volume":"31","author":"Sanyal","year":"1997","journal-title":"J. Psychiatr. Res."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/dna.1992.11.1","article-title":"Sequence alignment of the G-protein coupled receptor superfamily","volume":"11","author":"Probst","year":"1992","journal-title":"DNA Cell Biol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0135","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/S0021-9258(18)45962-5","article-title":"Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation","volume":"267","author":"Kjelsberg","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.phrs.2020.105124_bib0140","doi-asserted-by":"crossref","first-page":"10267","DOI":"10.1016\/S0021-9258(19)81509-0","article-title":"Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function","volume":"263","author":"Strader","year":"1988","journal-title":"J. Biol. Chem."},{"issue":"23","key":"10.1016\/j.phrs.2020.105124_bib0145","doi-asserted-by":"crossref","first-page":"13572","DOI":"10.1016\/S0021-9258(18)80035-7","article-title":"Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor","volume":"264","author":"Strader","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0150","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0165-6147(93)90106-T","article-title":"This is not a G protein-coupled receptor","volume":"14","author":"Hibert","year":"1993","journal-title":"Trends Pharmacol. Sci."},{"issue":"19","key":"10.1016\/j.phrs.2020.105124_bib0155","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1021\/jm00097a002","article-title":"Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors","volume":"35","author":"Trumpp-Kallmeyer","year":"1992","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/bph.12906","article-title":"Dopamine receptors \u2013 IUPHAR review 13","volume":"172","author":"Beaulieu","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib0165","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.febslet.2012.04.033","article-title":"Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation","volume":"586","author":"Brown","year":"2012","journal-title":"FEBS Lett."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0170","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0736-5748(00)00033-2","article-title":"Coupling of dopamine receptor subtypes to multiple and diverse G proteins","volume":"18","author":"Sidhu","year":"2000","journal-title":"Int. J. Dev. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib0175","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1073\/pnas.69.8.2145","article-title":"Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the \u201cdopamine receptor\u201d","volume":"69","author":"Kebabian","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5692","key":"10.1016\/j.phrs.2020.105124_bib0180","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/277093a0","article-title":"Multiple receptors for dopamine","volume":"277","author":"Kebabian","year":"1979","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0185","first-page":"321","article-title":"Signal transduction and gene control: the cAMP pathway","volume":"3","author":"Borrelli","year":"1992","journal-title":"Crit. Rev. Oncog."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib0190","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0006-3223(02)01405-1","article-title":"Preclinical models: status of basic research in depression","volume":"52","author":"Nestler","year":"2002","journal-title":"Biol. Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105124_bib0195","first-page":"83","article-title":"Regulation of 5-HT release from enterochromaffin cells","volume":"73","author":"Racke","year":"1996","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0200","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jchemneu.2010.03.004","article-title":"The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D","volume":"40","author":"Mori","year":"2010","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.phrs.2020.105124_bib0205","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pbb.2015.02.010","article-title":"Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1\/2, PKA and PKC activation","volume":"131","author":"Darmani","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1\u20133","key":"10.1016\/j.phrs.2020.105124_bib0210","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejphar.2012.09.008","article-title":"Cisplatin causes over-expression of tachykinin NK(1) receptors and increases ERK1\/2- and PKA- phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem","volume":"698","author":"Darmani","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2020.105124_bib0215","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejphar.2013.09.080","article-title":"Cyclophosphamide causes activation of protein kinase A (PKA) in the brainstem of vomiting least shrews (Cryptotis parva)","volume":"722","author":"Alkam","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0220","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1043-2760(99)00232-5","article-title":"Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor","volume":"11","author":"Naor","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0225","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0898-6568(00)00091-7","article-title":"Novel regulation of p38gamma by dopamine D2 receptors during hypoxia","volume":"12","author":"Conrad","year":"2000","journal-title":"Cell. Signal."},{"issue":"27","key":"10.1016\/j.phrs.2020.105124_bib0230","doi-asserted-by":"crossref","first-page":"28304","DOI":"10.1074\/jbc.M403899200","article-title":"Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase","volume":"279","author":"Beom","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"17","key":"10.1016\/j.phrs.2020.105124_bib0235","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1523\/JNEUROSCI.5236-05.2006","article-title":"The dopamine D2 receptor regulates the development of dopaminergic neurons via extracellular signal-regulated kinase and Nurr1 activation","volume":"26","author":"Kim","year":"2006","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0240","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1046\/j.1471-4159.1998.71030980.x","article-title":"D2 dopamine receptors stimulate mitogenesis through pertussis toxin-sensitive G proteins and Ras-involved ERK and SAP\/JNK pathways in rat C6-D2L glioma cells","volume":"71","author":"Luo","year":"1998","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib0245","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1046\/j.1471-4159.1998.70052139.x","article-title":"Activation of microtubule-associated protein kinase (Erk) and p70 S6 kinase by D2 dopamine receptors","volume":"70","author":"Welsh","year":"1998","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0250","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1471-4159.2005.03055.x","article-title":"Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases","volume":"93","author":"Wang","year":"2005","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib0255","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0898-6568(96)00074-5","article-title":"Signal transduction pathways modulated by the D2 subfamily of dopamine receptors","volume":"8","author":"Huff","year":"1996","journal-title":"Cell. Signal."},{"issue":"19","key":"10.1016\/j.phrs.2020.105124_bib0260","doi-asserted-by":"crossref","first-page":"10782","DOI":"10.1073\/pnas.1834556100","article-title":"Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2","volume":"100","author":"Wei","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2020.105124_bib0265","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.physiol.69.022405.154712","article-title":"Regulation of receptor trafficking by GRKs and arrestins","volume":"69","author":"Moore","year":"2007","journal-title":"Annu. Rev. Physiol."},{"issue":"5721","key":"10.1016\/j.phrs.2020.105124_bib0270","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1126\/science.1109237","article-title":"Transduction of receptor signals by beta-arrestins","volume":"308","author":"Lefkowitz","year":"2005","journal-title":"Science"},{"issue":"311","key":"10.1016\/j.phrs.2020.105124_bib0275","doi-asserted-by":"crossref","first-page":"cm14","DOI":"10.1126\/stke.3112005cm14","article-title":"Angiotensin II-stimulated signaling through G proteins and beta-arrestin","volume":"2005","author":"Shenoy","year":"2005","journal-title":"Sci. STKE"},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0280","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1124\/pr.109.002436","article-title":"Beyond desensitization: physiological relevance of arrestin-dependent signaling","volume":"62","author":"Luttrell","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0285","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.phrs.2012.09.012","article-title":"Multiple signaling routes involved in the regulation of adenylyl cyclase and extracellular regulated kinase by dopamine D(2) and D(3) receptors","volume":"67","author":"Jin","year":"2013","journal-title":"Pharmacol. Res."},{"issue":"23","key":"10.1016\/j.phrs.2020.105124_bib0290","doi-asserted-by":"crossref","first-page":"8701","DOI":"10.1523\/JNEUROSCI.20-23-08701.2000","article-title":"Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties","volume":"20","author":"Valjent","year":"2000","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0295","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1471-4159.2001.00051.x","article-title":"Cyclic AMP and mitogen-activated protein kinases are required for glutamate-dependent cyclic AMP response element binding protein and Elk-1 phosphorylation in the dorsal striatum in vivo","volume":"76","author":"Choe","year":"2001","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib0300","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1111\/j.1471-4159.2005.03500.x","article-title":"Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A","volume":"95","author":"Mattson","year":"2005","journal-title":"J. Neurochem."},{"issue":"12","key":"10.1016\/j.phrs.2020.105124_bib0305","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.tins.2006.10.005","article-title":"Role of ERK in cocaine addiction","volume":"29","author":"Lu","year":"2006","journal-title":"Trends Neurosci."},{"issue":"51","key":"10.1016\/j.phrs.2020.105124_bib0310","doi-asserted-by":"crossref","first-page":"13287","DOI":"10.1523\/JNEUROSCI.3795-06.2006","article-title":"c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes","volume":"26","author":"Zhang","year":"2006","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0315","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.coph.2006.08.012","article-title":"ERK2: a logical AND gate critical for drug-induced plasticity?","volume":"7","author":"Girault","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"issue":"5240","key":"10.1016\/j.phrs.2020.105124_bib0320","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0325","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/2836","article-title":"The MAPK cascade is required for mammalian associative learning","volume":"1","author":"Atkins","year":"1998","journal-title":"Nat. Neurosci."},{"issue":"22","key":"10.1016\/j.phrs.2020.105124_bib0330","doi-asserted-by":"crossref","first-page":"12866","DOI":"10.1073\/pnas.96.22.12866","article-title":"MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia","volume":"96","author":"Alessandrini","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0335","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02970136","article-title":"Role of reactive oxygen species in extracellular signal-regulated protein kinase phosphorylation and 6-hydroxydopamine cytotoxicity","volume":"28","author":"Kulich","year":"2003","journal-title":"J. Biosci."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104718","article-title":"Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+\/CaMKII-dependent ERK1\/2 signaling in the least shrew (Cryptotis parva)","volume":"9","author":"Zhong","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2020.105124_bib0345","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neuint.2018.11.012","article-title":"Intracellular emetic signaling cascades by which the selective neurokinin type 1 receptor (NK1R) agonist GR73632 evokes vomiting in the least shrew (Cryptotis parva)","volume":"122","author":"Zhong","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phrs.2020.105124_bib0350","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuropharm.2015.11.023","article-title":"Thapsigargin-induced activation of Ca(2+)-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew","volume":"103","author":"Zhong","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2020.105124_bib0355","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejphar.2018.06.035","article-title":"Intracellular emetic signaling evoked by the L-type Ca(2+) channel agonist FPL64176 in the least shrew (Cryptotis parva)","volume":"834","author":"Zhong","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2020.105124_bib0360","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev.pharmtox.011008.145634","article-title":"Akt\/GSK3 signaling in the action of psychotropic drugs","volume":"49","author":"Beaulieu","year":"2009","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"20","key":"10.1016\/j.phrs.2020.105124_bib0365","doi-asserted-by":"crossref","first-page":"8911","DOI":"10.1523\/JNEUROSCI.22-20-08911.2002","article-title":"Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation","volume":"22","author":"Brami-Cherrier","year":"2002","journal-title":"J. Neurosci."},{"issue":"5649","key":"10.1016\/j.phrs.2020.105124_bib0370","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1126\/science.1089681","article-title":"Diverse psychotomimetics act through a common signaling pathway","volume":"302","author":"Svenningsson","year":"2003","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0375","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1124\/mol.110.065409","article-title":"Signaling pathways leading to phosphorylation of Akt and GSK-3beta by activation of cloned human and rat cerebral D(2)and D(3) receptors","volume":"79","author":"Mannoury la Cour","year":"2011","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0380","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuropharm.2011.05.010","article-title":"Low dose methamphetamine mediates neuroprotection through a PI3K-AKT pathway","volume":"61","author":"Rau","year":"2011","journal-title":"Neuropharmacology"},{"issue":"19","key":"10.1016\/j.phrs.2020.105124_bib0385","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.1128\/MCB.24.19.8778-8789.2004","article-title":"Protein phosphatase 2A negatively regulates insulin\u2019s metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes","volume":"24","author":"Ugi","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0390","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cell.2005.05.012","article-title":"An Akt\/beta-arrestin 2\/PP2A signaling complex mediates dopaminergic neurotransmission and behavior","volume":"122","author":"Beaulieu","year":"2005","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.phrs.2020.105124_bib0395","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1073\/pnas.0307921101","article-title":"Lithium antagonizes dopamine-dependent behaviors mediated by an AKT\/glycogen synthase kinase 3 signaling cascade","volume":"101","author":"Beaulieu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0400","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tins.2007.02.002","article-title":"Schizophrenia as a GSK-3 dysregulation disorder","volume":"30","author":"Lovestone","year":"2007","journal-title":"Trends Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib0405","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/sj.npp.1301254","article-title":"Strain differences in lithium attenuation of d- amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium","volume":"32","author":"Gould","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"35","key":"10.1016\/j.phrs.2020.105124_bib0410","doi-asserted-by":"crossref","first-page":"9022","DOI":"10.1523\/JNEUROSCI.5216-05.2006","article-title":"Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania","volume":"26","author":"Prickaerts","year":"2006","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0415","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/jnr.10426","article-title":"Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade","volume":"70","author":"Kihara","year":"2002","journal-title":"J. Neurosci. Res."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib0420","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1080\/10715760802429021","article-title":"Phosphoinositide 3-kinase\/Akt signalling is responsible for the differential susceptibility of myoblasts and myotubes to menadione-induced oxidative stress","volume":"42","author":"Lim","year":"2008","journal-title":"Free Radic. Res."},{"issue":"22","key":"10.1016\/j.phrs.2020.105124_bib0425","doi-asserted-by":"crossref","first-page":"15469","DOI":"10.1074\/jbc.M707238200","article-title":"Differential modulation of Akt\/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses","volume":"283","author":"Nair","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib0430","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1055\/s-2007-986688","article-title":"Oxidative stress is associated with clinical severity of nausea and vomiting of pregnancy","volume":"24","author":"Verit","year":"2007","journal-title":"Am. J. Perinatol."},{"issue":"4\u20135","key":"10.1016\/j.phrs.2020.105124_bib0435","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10565-015-9307-8","article-title":"Oxidative damage induced by retching; antiemetic and neuroprotective role of Sambucus ebulus L","volume":"31","author":"Fathi","year":"2015","journal-title":"Cell Biol. Toxicol."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib0440","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-4159.2011.07618.x","article-title":"Pre-synaptic dopamine D(3) receptor mediates cocaine-induced structural plasticity in mesencephalic dopaminergic neurons via ERK and Akt pathways","volume":"120","author":"Collo","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2020.105124_bib0445","article-title":"Naoxintong protects primary neurons from oxygen-glucose deprivation\/reoxygenation induced injury through PI3K-Akt signaling pathway","volume":"2016","author":"Ma","year":"2016","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0450","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S1461145706006857","article-title":"Not only lithium: regulation of glycogen synthase kinase-3 by antipsychotics and serotonergic drugs","volume":"10","author":"Beaulieu","year":"2007","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0455","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1017\/S1461145706006547","article-title":"Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics","volume":"10","author":"Li","year":"2007","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0460","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1073\/pnas.0711496105","article-title":"Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency","volume":"105","author":"Beaulieu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2020.105124_bib0465","article-title":"The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva)","volume":"132","author":"Zhong","year":"2019","journal-title":"Neurochem. Int."},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib0470","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0006-3223(98)00017-1","article-title":"A phosphoinositide-linked dopamine D1 receptor mediates repetitive jaw movements in rats","volume":"44","author":"Rosengarten","year":"1998","journal-title":"Biol. Psychiatry"},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0475","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0166-2236(90)90107-L","article-title":"Functional architecture of basal ganglia circuits: neural substrates of parallel processing","volume":"13","author":"Alexander","year":"1990","journal-title":"Trends Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0480","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0169-328X(93)90033-L","article-title":"Carbachol-induced phosphoinositide metabolism in slices of rat substantia nigra pars reticulata","volume":"19","author":"Arias-Montano","year":"1993","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0485","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1124\/mol.51.1.6","article-title":"D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice","volume":"51","author":"Friedman","year":"1997","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0490","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01474676","article-title":"Transmembrane signaling through phospholipase C in human cortical membranes","volume":"18","author":"Wallace","year":"1993","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0495","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1046\/j.1471-4159.1997.69020639.x","article-title":"Comparison of [3H]phosphatidylinositol and [3H]phosphatidylinositol 4,5-bisphosphate hydrolysis in postmortem human brain membranes and characterization of stimulation by dopamine D1 receptors","volume":"69","author":"Pacheco","year":"1997","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib0500","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0028-3908(01)00011-9","article-title":"SKF83959 exhibits biochemical agonism by stimulating [(35)S]GTP gamma S binding and phosphoinositide hydrolysis in rat and monkey brain","volume":"40","author":"Panchalingam","year":"2001","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0505","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0014-2999(87)90724-2","article-title":"Dopamine D2 receptor stimulation decreases the inositol trisphosphate level of rat striatal slices","volume":"136","author":"Pizzi","year":"1987","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0510","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0006-8993(88)90222-3","article-title":"Dopamine D2 receptor stimulation inhibits inositol phosphate generating system in rat striatal slices","volume":"456","author":"Pizzi","year":"1988","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0515","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pharmthera.2010.05.003","article-title":"Pharmacology of signaling induced by dopamine D(1)-like receptor activation","volume":"128","author":"Undieh","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0520","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0028-3908(99)00106-9","article-title":"Dopaminergic behaviors and signal transduction mediated through adenylate cyclase and phospholipase C pathways","volume":"39","author":"Undie","year":"2000","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0525","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj2200345","article-title":"Inositol trisphosphate and diacylglycerol as second messengers","volume":"220","author":"Berridge","year":"1984","journal-title":"Biochem. J."},{"issue":"5992","key":"10.1016\/j.phrs.2020.105124_bib0530","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/312315a0","article-title":"Inositol trisphosphate, a novel second messenger in cellular signal transduction","volume":"312","author":"Berridge","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2020.105124_bib0535","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fonc.2017.00140","article-title":"IP3 receptor-mediated calcium signaling and its role in autophagy in cancer","volume":"7","author":"Kania","year":"2017","journal-title":"Front. Oncol."},{"issue":"2\u20133","key":"10.1016\/j.phrs.2020.105124_bib0540","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-5793(01)02281-5","article-title":"Functional coupling with Galpha(q) and Galpha (i1) protein subunits promotes high-affinity agonist binding to the neurotensin receptor NTS-1 expressed in Escherichia coli","volume":"493","author":"Grisshammer","year":"2001","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0545","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1073\/pnas.0604049104","article-title":"D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq\/11 in the striatum","volume":"104","author":"Rashid","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2020.105124_bib0550","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev.biochem.70.1.281","article-title":"Regulation of phosphoinositide-specific phospholipase C","volume":"70","author":"Rhee","year":"2001","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0555","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1124\/mol.63.1.89","article-title":"Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory","volume":"63","author":"Charles","year":"2003","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0560","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1111\/j.1476-5381.1995.tb16420.x","article-title":"Pharmacological characterization of behavioural responses to SK&F 83959 in relation to\u2019 D1-like\u2019 dopamine receptors not linked to adenylyl cyclase","volume":"116","author":"Deveney","year":"1995","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib0565","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1248\/bpb.28.1342","article-title":"Neuronal Ca2+\/calmodulin-dependent protein kinase II--discovery, progress in a quarter of a century, and perspective: implication for learning and memory","volume":"28","author":"Yamauchi","year":"2005","journal-title":"Biol. Pharm. Bull."},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib0570","first-page":"805","article-title":"Phospholipase D and its essential role in cancer","volume":"40","author":"Cho","year":"2017","journal-title":"Mol. Cells"},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0575","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1152\/physrev.1997.77.2.303","article-title":"Phospholipase D: enzymology, mechanisms of regulation, and function","volume":"77","author":"Exton","year":"1997","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0580","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0026-895X(24)12083-4","article-title":"The D2s dopamine receptor stimulates phospholipase D activity: a novel signaling pathway for dopamine","volume":"58","author":"Senogles","year":"2000","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0585","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neulet.2004.08.033","article-title":"D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway","volume":"371","author":"Everett","year":"2004","journal-title":"Neurosci. Lett."},{"issue":"6674","key":"10.1016\/j.phrs.2020.105124_bib0590","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/32937","article-title":"Rhodopsin-family receptors associate with small G proteins to activate phospholipase D","volume":"392","author":"Mitchell","year":"1998","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0595","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/cdd.2014.30","article-title":"Phospholipase D1 regulates autophagic flux and clearance of alpha-synuclein aggregates","volume":"21","author":"Bae","year":"2014","journal-title":"Cell Death Differ."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0600","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.bmcl.2009.02.057","article-title":"Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: impact of alternative halogenated privileged structures for PLD1 specificity","volume":"19","author":"Lewis","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"18","key":"10.1016\/j.phrs.2020.105124_bib0605","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1021\/jm100814g","article-title":"Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1 -phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor","volume":"53","author":"Lavieri","year":"2010","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib0610","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.2217\/fon.09.110","article-title":"Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis","volume":"5","author":"Su","year":"2009","journal-title":"Future Oncol."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib0615","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1016\/j.bmcl.2009.02.125","article-title":"Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5] decan-4-one privileged structure that engenders PLD2 selectivity","volume":"19","author":"Lavieri","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0620","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nchembio.140","article-title":"Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness","volume":"5","author":"Scott","year":"2009","journal-title":"Nat. Chem. Biol."},{"issue":"12","key":"10.1016\/j.phrs.2020.105124_bib0625","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/j.cellsig.2013.08.021","article-title":"Mechanism of dopamine D2 receptor-induced Ca(2+) release in PC-12 cells","volume":"25","author":"Fregeau","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.phrs.2020.105124_bib0630","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.autneu.2016.07.006","article-title":"Ca(2+) signaling and emesis: Recent progress and new perspectives","volume":"202","author":"Zhong","year":"2017","journal-title":"Auton. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib0635","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1074\/jbc.M008215200","article-title":"Molecular and functional characterization of a family of rat brain T-type calcium channels","volume":"276","author":"McRory","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2020.105124_bib0640","first-page":"158","article-title":"Apical entry channels in calcium-transporting epithelia","volume":"18","author":"Peng","year":"2003","journal-title":"News Physiol. Sci."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0645","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1471-4159.2006.03901.x","article-title":"Dopamine receptor regulation of Ca2+ levels in individual isolated nerve terminals from rat striatum: comparison of presynaptic D1-like and D2-like receptors","volume":"98","author":"Wu","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2020.105124_bib0650","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejphar.2013.08.052","article-title":"Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT(3) receptor antagonist palonosetron in the least shrew (Cryptotis parva)","volume":"722","author":"Darmani","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0655","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF03020488","article-title":"Calcium channels\u2013basic aspects of their structure, function and gene encoding; anesthetic action on the channels\u2013a review","volume":"49","author":"Yamakage","year":"2002","journal-title":"Can. J. Anaesth."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0660","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0896-6273(95)90183-3","article-title":"Determinants of PKC-dependent modulation of a family of neuronal calcium channels","volume":"15","author":"Stea","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2020.105124_bib0665","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1242\/jeb.184.1.89","article-title":"Calcium handling by the mammalian kidney","volume":"184","author":"Bindels","year":"1993","journal-title":"J. Exp. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib0670","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/ki.1995.432","article-title":"Stimulation of calcium transport by amiloride in mouse distal convoluted tubule cells","volume":"48","author":"Friedman","year":"1995","journal-title":"Kidney Int."},{"issue":"11\u201312","key":"10.1016\/j.phrs.2020.105124_bib0675","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/j.molimm.2009.03.017","article-title":"Ca v 1.2 L-type Ca2+ channel protects mast cells against activation- induced cell death by preventing mitochondrial integrity disruption","volume":"46","author":"Suzuki","year":"2009","journal-title":"Mol. Immunol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0680","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.molimm.2008.11.011","article-title":"L-type Ca2+ channels in mast cells: activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels","volume":"46","author":"Yoshimaru","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phrs.2020.105124_bib0685","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pbb.2014.03.005","article-title":"Broad-spectrum antiemetic efficacy of the L-type calcium channel blocker amlodipine in the least shrew (Cryptotis parva)","volume":"120","author":"Zhong","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"47","key":"10.1016\/j.phrs.2020.105124_bib0690","doi-asserted-by":"crossref","first-page":"32591","DOI":"10.1074\/jbc.M109.019687","article-title":"The endoplasmic reticulum of dorsal root ganglion neurons contains functional TRPV1 channels","volume":"284","author":"Gallego-Sandin","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib0695","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1002\/jcp.25704","article-title":"Versatile roles of intracellularly located TRPV1 channel","volume":"232","author":"Zhao","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0700","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1073\/pnas.97.7.3655","article-title":"Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human","volume":"97","author":"Mezey","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105124_bib0705","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0169-328X(01)00313-8","article-title":"Pharmacological characterization of vanilloid receptor located in the brain","volume":"98","author":"Szabo","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0710","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","article-title":"Vanilloid (Capsaicin) receptors and mechanisms","volume":"51","author":"Szallasi","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phrs.2020.105124_bib0715","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2013.08.051","article-title":"Additive antiemetic efficacy of low-doses of the cannabinoid CB(1\/2) receptor agonist Delta(9)-THC with ultralow-doses of the vanilloid TRPV1 receptor agonist resiniferatoxin in the least shrew (Cryptotis parva)","volume":"722","author":"Darmani","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2020.105124_bib0720","article-title":"Ultra-low doses of the transient receptor potential vanilloid 1 agonist, resiniferatoxin, prevents vomiting evoked by diverse emetogens in the least shrew (Cryptotis parva)","author":"Darmani","year":"2019","journal-title":"Behav. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0725","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1476-5381.1992.tb12781.x","article-title":"Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin","volume":"107","author":"Bevan","year":"1992","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib0730","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1113\/JP271198","article-title":"Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons","volume":"594","author":"Chakraborty","year":"2016","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0735","doi-asserted-by":"crossref","first-page":"G631","DOI":"10.1152\/ajpgi.00178.2018","article-title":"Descending monoaminergic pathways projecting to the spinal defecation center enhance colorectal motility in rats","volume":"315","author":"Naitou","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"Pt 3","key":"10.1016\/j.phrs.2020.105124_bib0740","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1469-7793.2001.00813.x","article-title":"Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide","volume":"534","author":"Vellani","year":"2001","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0745","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0896-6273(02)00802-4","article-title":"cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation","volume":"35","author":"Bhave","year":"2002","journal-title":"Neuron"},{"issue":"Pt 12","key":"10.1016\/j.phrs.2020.105124_bib0750","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1093\/brain\/awv297","article-title":"TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson\u2019s disease via CNTF","volume":"138","author":"Nam","year":"2015","journal-title":"Brain"},{"issue":"20","key":"10.1016\/j.phrs.2020.105124_bib0755","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.1523\/JNEUROSCI.0181-09.2009","article-title":"Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release","volume":"29","author":"Patel","year":"2009","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0760","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physrev.1994.74.3.595","article-title":"Molecular and cellular physiology of intracellular calcium stores","volume":"74","author":"Pozzan","year":"1994","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0765","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1152\/physrev.00035.2006","article-title":"Inositol trisphosphate receptor Ca2+ release channels","volume":"87","author":"Foskett","year":"2007","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0770","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0143-4160(96)90009-3","article-title":"Calcium-induced calcium release in neurones","volume":"19","author":"Verkhratsky","year":"1996","journal-title":"Cell Calcium"},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0775","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physrev.00013.2002","article-title":"Ryanodine receptor calcium release channels","volume":"82","author":"Fill","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2020.105124_bib0780","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2008.03.077","article-title":"Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists","volume":"1214","author":"Darmani","year":"2008","journal-title":"Brain Res."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib0785","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1111\/j.1476-5381.2010.01176.x","article-title":"Regulation of nausea and vomiting by cannabinoids","volume":"163","author":"Parker","year":"2011","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0790","doi-asserted-by":"crossref","first-page":"G180","DOI":"10.1152\/ajpgi.00413.2002","article-title":"Musings on the wanderer: what\u2019s new in our understanding of vago-vagal reflexes? III. Activity-dependent plasticity in vago-vagal reflexes controlling the stomach","volume":"284","author":"Travagli","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.phrs.2020.105124_bib0795","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.physiol.68.040504.094635","article-title":"Brainstem circuits regulating gastric function","volume":"68","author":"Travagli","year":"2006","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0800","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.brainres.2004.01.056","article-title":"Distribution and ultrastructure of dopaminergic neurons in the dorsal motor nucleus of the vagus projecting to the stomach of the rat","volume":"1006","author":"Hayakawa","year":"2004","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0805","first-page":"193","article-title":"Evidence for the existence of L-dopa- and dopamine-immunoreactive nerve cell bodies in the caudal part of the dorsal motor nucleus of the vagus nerve","volume":"3","author":"Manier","year":"1990","journal-title":"J. Chem. Neuroanat."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib0810","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0361-9230(82)90005-3","article-title":"Dopaminergic mechanisms in the nucleus tractus solitarius and effects on blood pressure","volume":"8","author":"Granata","year":"1982","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0815","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/(SICI)1098-2396(199611)24:3<224::AID-SYN4>3.0.CO;2-G","article-title":"Distribution of dopamine D1-D4 receptor subtypes in human dorsal vagal complex","volume":"24","author":"Hyde","year":"1996","journal-title":"Synapse"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105124_bib0820","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.autneu.2009.08.002","article-title":"Serotonin release and uptake in the gastrointestinal tract","volume":"153","author":"Bertrand","year":"2010","journal-title":"Auton. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0825","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00304213","article-title":"Amine mechanisms in enterochromaffin and enterochromaffin-like cells of gastric mucosa in various mammals","volume":"21","author":"Hakanson","year":"1970","journal-title":"Histochemie"},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib0830","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1210\/jcem.82.11.4339","article-title":"Substantial production of dopamine in the human gastrointestinal tract","volume":"82","author":"Eisenhofer","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0835","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1172\/JCI110504","article-title":"Dopamine stimulation of active Na and Cl absorption in rabbit ileum: interaction with alpha 2-adrenergic and specific dopamine receptors","volume":"69","author":"Donowitz","year":"1982","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0840","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF01537410","article-title":"Dopamine interrupts gastrointestinal fed motility pattern in humans. Effect on motilin and somatostatin blood levels","volume":"35","author":"Marzio","year":"1990","journal-title":"Dig. Dis. Sci."},{"issue":"18","key":"10.1016\/j.phrs.2020.105124_bib0845","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/0024-3205(83)90100-5","article-title":"Dopamine produces vasodilation in specific regions and layers of the rabbit gastrointestinal tract","volume":"32","author":"Kullmann","year":"1983","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib0850","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/BF01537589","article-title":"Dopamine in gastrointestinal disease","volume":"35","author":"Glavin","year":"1990","journal-title":"Dig. Dis. Sci."},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib0855","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1177\/40.11.1431057","article-title":"Demonstration of dopamine-immunoreactive cells in the proximal convoluted tubule of gerbil (Meriones unguiculatus) kidney","volume":"40","author":"Dawirs","year":"1992","journal-title":"J. Histochem. Cytochem."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib0860","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1177\/40.8.1619282","article-title":"Demonstration of dopamine-immunoreactive cells in the gastrointestinal tract of gerbils (Meriones unguiculatus)","volume":"40","author":"Dawirs","year":"1992","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.phrs.2020.105124_bib0865","first-page":"S14","article-title":"Non-neuronal dopamine in the gastrointestinal system","volume":"26","author":"Mezey","year":"1999","journal-title":"Clin. Exp. Pharmacol. Physiol. Suppl."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0870","doi-asserted-by":"crossref","first-page":"R599","DOI":"10.1152\/ajpregu.2000.279.2.R599","article-title":"Identification and regional distribution of the dopamine D(1A) receptor in the gastrointestinal tract","volume":"279","author":"Vaughan","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0875","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0016-5085(81)90189-X","article-title":"Effect of dopamine on opossum duodenal smooth muscle","volume":"80","author":"Anuras","year":"1981","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0880","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0016-5085(79)90340-8","article-title":"Effect of dopamine on human gastric and pancreatic secretion","volume":"76","author":"Valenzuela","year":"1979","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib0885","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000054332","article-title":"Dopamine produced by the stomach may act as a paracrine\/autocrine hormone in the rat","volume":"67","author":"Mezey","year":"1998","journal-title":"Neuroendocrinology"},{"issue":"10","key":"10.1016\/j.phrs.2020.105124_bib0890","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1523\/JNEUROSCI.4720-05.2006","article-title":"Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice","volume":"26","author":"Li","year":"2006","journal-title":"J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105124_bib0895","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.autneu.2013.01.007","article-title":"Distribution of dopamine receptors D1- and D2 -immunoreactive neurons in the dorsal motor nucleus of vagus in rats","volume":"176","author":"Cai","year":"2013","journal-title":"Auton. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0900","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/ije\/17.2.270","article-title":"Cervical cancer mortality in the Netherlands","volume":"17","author":"van der Graaf","year":"1988","journal-title":"Int. J. Epidemiol."},{"issue":"16","key":"10.1016\/j.phrs.2020.105124_bib0905","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/0024-3205(95)00082-8","article-title":"Different neurotransmitter systems are involved in the development of esophageal achalasia","volume":"56","author":"Sigala","year":"1995","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib0910","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2036.2004.01867.x","article-title":"Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics","volume":"19","author":"Tonini","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"17","key":"10.1016\/j.phrs.2020.105124_bib0915","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1021\/acs.jmedchem.7b00151","article-title":"Return of D4 dopamine receptor antagonists in drug discovery","volume":"60","author":"Lindsley","year":"2017","journal-title":"J. Med. Chem."},{"issue":"4306","key":"10.1016\/j.phrs.2020.105124_bib0920","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/169800b0","article-title":"Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5- hydroxytryptamine","volume":"169","author":"Erspamer","year":"1952","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib0925","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1073\/pnas.91.8.2935","article-title":"Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide","volume":"91","author":"Cetin","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2020.105124_bib0930","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1038\/ctg.2012.8","article-title":"Serotonin and GI disorders: an update on clinical and experimental studies","volume":"3","author":"Manocha","year":"2012","journal-title":"Clin. Transl. Gastroenterol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0935","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/BF00219790","article-title":"Distribution of intrinsic nerve cell bodies and axons which take up aromatic amines and their precursors in the small intestine of the guinea-pig","volume":"188","author":"Furness","year":"1978","journal-title":"Cell Tissue Res."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib0940","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1523\/JNEUROSCI.3982-03.2004","article-title":"Enteric dopaminergic neurons: definition, developmental lineage, and effects of extrinsic denervation","volume":"24","author":"Li","year":"2004","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib0945","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrgastro.2016.107","article-title":"The bowel and beyond: the enteric nervous system in neurological disorders","volume":"13","author":"Rao","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib0950","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11894-010-0129-9","article-title":"Enteric nervous system in the small intestine: pathophysiology and clinical implications","volume":"12","author":"Nezami","year":"2010","journal-title":"Curr. Gastroenterol. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0955","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00001574-200003000-00004","article-title":"5-HT (serotonin) physiology and related drugs","volume":"16","author":"Gershon","year":"2000","journal-title":"Curr. Opin. Gastroenterol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib0960","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0163-7258(96)00195-7","article-title":"Tachykinins in the gut. Part I. Expression, release and motor function","volume":"73","author":"Holzer","year":"1997","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0965","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0022-3565(25)24462-7","article-title":"Dopamine and norepinephrine in the gastrointestinal tract of mice and the effects of neurotoxins","volume":"244","author":"Eaker","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib0970","first-page":"G1044","article-title":"Neuronal release of endogenous dopamine from corpus of guinea pig stomach","volume":"273","author":"Shichijo","year":"1997","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0975","first-page":"71","article-title":"Distribution of dopamine transporter in the rat: an immunohistochemical study","volume":"32","author":"Mitsuma","year":"1998","journal-title":"Endocr. Regul."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib0980","doi-asserted-by":"crossref","first-page":"G311","DOI":"10.1152\/ajpgi.2000.279.2.G311","article-title":"Mice lacking the dopamine transporter display altered regulation of distal colonic motility","volume":"279","author":"Walker","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"8979","key":"10.1016\/j.phrs.2020.105124_bib0985","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0140-6736(95)92707-7","article-title":"Dopaminergic defect of enteric nervous system in Parkinson\u2019s disease patients with chronic constipation","volume":"346","author":"Singaram","year":"1995","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib0990","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.pbb.2009.08.010","article-title":"Receptor-selective agonists induce emesis and Fos expression in the brain and enteric nervous system of the least shrew (Cryptotis parva)","volume":"94","author":"Ray","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2020.105124_bib0995","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fpsyt.2018.00044","article-title":"Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders","volume":"9","author":"Breit","year":"2018","journal-title":"Front. Psychiatry"},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1000","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1139\/y90-037","article-title":"Respiratory muscle control during vomiting","volume":"68","author":"Miller","year":"1990","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib1005","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/j.1476-5381.1995.tb13352.x","article-title":"Functional dopamine D2 receptors on rat vagal afferent neurones","volume":"114","author":"Lawrence","year":"1995","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1010","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S1734-1140(12)70933-7","article-title":"Chronic impairment of the vagus nerve function leads to inhibition of dopamine but not serotonin neurons in rat brain structures","volume":"64","author":"Ziomber","year":"2012","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1015","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1748-5827.2009.00820.x","article-title":"Emesis in dogs: a review","volume":"51","author":"Elwood","year":"2010","journal-title":"J. Small Anim. Pract."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib1020","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0168-0102(09)80001-1","article-title":"The Botzinger complex as the pattern generator for retching and vomiting in the dog","volume":"12","author":"Fukuda","year":"1991","journal-title":"Neurosci. Res."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1025","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0168-0102(92)90079-R","article-title":"Non-respiratory neurons in the Botzinger complex exhibiting appropriate firing patterns to generate the emetic act in dogs","volume":"14","author":"Fukuda","year":"1992","journal-title":"Neurosci. Res."},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib1030","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1097\/00001756-199707280-00033","article-title":"Descending pathway from the central pattern generator of vomiting","volume":"8","author":"Koga","year":"1997","journal-title":"Neuroreport"},{"issue":"2\u20133","key":"10.1016\/j.phrs.2020.105124_bib1035","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.appet.2007.09.015","article-title":"Why is the neurobiology of nausea and vomiting so important?","volume":"50","author":"Horn","year":"2008","journal-title":"Appetite"},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1040","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s002210050265","article-title":"The central pattern generator for vomiting may exist in the reticular area dorsomedial to the retrofacial nucleus in dogs","volume":"118","author":"Koga","year":"1998","journal-title":"Exp. Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105124_bib1045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.autneu.2007.03.002","article-title":"Similarities of the neuronal circuit for the induction of fictive vomiting between ferrets and dogs","volume":"136","author":"Onishi","year":"2007","journal-title":"Auton. Neurosci."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1050","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.conb.2011.05.011","article-title":"Neuromodulation and flexibility in central pattern generator networks","volume":"21","author":"Harris-Warrick","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.phrs.2020.105124_bib1055","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2013.10.008","article-title":"The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting","volume":"722","author":"Chu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1060","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/jnnp.68.6.685","article-title":"Dopamine agonists: their role in the treatment of Parkinson\u2019s disease","volume":"68","author":"Brooks","year":"2000","journal-title":"J. Neurol Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0016-5085(19)36357-7","article-title":"A new concept of organization of the central emetic mechanism: recent studies on the sites of action of apomorphine, copper sulfate and cardiac glycosides","volume":"22","author":"Wang","year":"1952","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0014-2999(87)90009-4","article-title":"Central mechanisms for apomorphine-induced emesis in the dog","volume":"144","author":"Harding","year":"1987","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1075","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0014-2999(74)90262-3","article-title":"Carbidopa attenuation of L-DOPA emesis in dogs: evidence for a cerebral site of action outside the blood-brain barrier","volume":"25","author":"Lotti","year":"1974","journal-title":"Eur. J. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.phrs.2020.105124_bib1080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejphar.2008.08.011","article-title":"Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2\/5- HT(1A) antipsychotic compounds","volume":"597","author":"Depoortere","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib1085","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0028-3908(92)90034-M","article-title":"The neuropharmacology of loperamide-induced emesis in the ferret: the role of the area postrema, vagus, opiate and 5-HT3 receptors","volume":"31","author":"Bhandari","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2020.105124_bib1090","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/aja.1001070307","article-title":"A study of the structure of the area postrema with Golgi methods","volume":"107","author":"Morest","year":"1960","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.phrs.2020.105124_bib1095","series-title":"Oxford Clinical Communications., Serotonin and the Scientific Basis of Anti-emetic Therapy","author":"Reynolds","year":"1995"},{"issue":"11\u201312","key":"10.1016\/j.phrs.2020.105124_bib1100","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s007020050222","article-title":"The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew)","volume":"106","author":"Darmani","year":"1999","journal-title":"J. Neural Transm. Vienna"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1105","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0022-3565(24)37948-0","article-title":"Long-term sequential determination of behavioral ontogeny of 5-HT1A and 5-HT2 receptor functions in the rat","volume":"288","author":"Darmani","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"10","key":"10.1016\/j.phrs.2020.105124_bib1110","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s00702-003-0027-5","article-title":"Dopamine receptor agonists in current clinical use: comparative dopamine receptor binding profiles defined in the human striatum","volume":"110","author":"Gerlach","year":"2003","journal-title":"J. Neural Transm. Vienna"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/187152706784111551","article-title":"The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders","volume":"5","author":"Sokoloff","year":"2006","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"12","key":"10.1016\/j.phrs.2020.105124_bib1120","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1007\/s00018-010-0293-y","article-title":"The dopamine D4 receptor: biochemical and signalling properties","volume":"67","author":"Rondou","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1125","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0922-4106(95)90013-6","article-title":"Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors","volume":"290","author":"Mierau","year":"1995","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0014-2999(96)00454-2","article-title":"Inhibition of dopamine neuron firing by pramipexole, a dopamine D3 receptor-preferring agonist: comparison to other dopamine receptor agonists","volume":"312","author":"Piercey","year":"1996","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1135","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1124\/jpet.102.039867","article-title":"Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes","volume":"303","author":"Millan","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1140","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0091-3057(91)90603-Y","article-title":"Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist","volume":"38","author":"Eden","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2\u20133","key":"10.1016\/j.phrs.2020.105124_bib1145","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0014-2999(98)00896-6","article-title":"Functional potencies of new antiparkinsonian drugs at recombinant human dopamine D1, D2 and D3 receptors","volume":"366","author":"Perachon","year":"1999","journal-title":"Eur. J. Pharmacol."},{"issue":"1 Pt 2","key":"10.1016\/j.phrs.2020.105124_bib1150","first-page":"17S","article-title":"Clinical pharmacology of dopamine agonists","volume":"20","author":"Lam","year":"2000","journal-title":"Pharmacotherapy"},{"issue":"21","key":"10.1016\/j.phrs.2020.105124_bib1155","doi-asserted-by":"crossref","first-page":"L347","DOI":"10.1016\/0024-3205(95)02186-M","article-title":"A dopamine D3 receptor agonist, 7-OH-DPAT, causes vomiting in the dog","volume":"57","author":"Yoshida","year":"1995","journal-title":"Life Sci."},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib1160","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.sleep.2014.05.009","article-title":"Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)","volume":"15","author":"Earley","year":"2014","journal-title":"Sleep Med."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1165","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41398-017-0071-9","article-title":"Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience","volume":"8","author":"Kesby","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.phrs.2020.105124_bib1170","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/BF01485901","article-title":"[Distribution of noradrenaline and dopamine (3 -hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system]","volume":"38","author":"Ehringer","year":"1960","journal-title":"Klin. Wochenschr."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib1175","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2147\/NDT.S2006","article-title":"Current approaches to the treatment of Parkinson\u2019s disease","volume":"4","author":"Jankovic","year":"2008","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1180","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2165\/00023210-199605050-00006","article-title":"Comparative review of dopamine receptor agonists in Parkinson\u2019s disease","volume":"5","author":"Uitti","year":"1996","journal-title":"CNS Drugs"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1185","first-page":"89","article-title":"Parkinson\u2019s disease: drug therapy","volume":"6","author":"Oertel","year":"1997","journal-title":"Baillieres Clin. Neurol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib1190","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/jnnp.57.9.1034","article-title":"A randomised controlled study comparing bromocriptine to which levodopa was later added, with levodopa alone in previously untreated patients with Parkinson\u2019s disease: a five year follow up","volume":"57","author":"Montastruc","year":"1994","journal-title":"J. Neurol Neurosurg. Psychiatry"},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1195","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/mds.26422","article-title":"Apomorphine: a potential modifier of amyloid deposition in Parkinson\u2019s disease?","volume":"31","author":"Yarnall","year":"2016","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1200","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.3390\/molecules17055289","article-title":"The pharmacological properties and therapeutic use of apomorphine","volume":"17","author":"Ribaric","year":"2012","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1205","first-page":"69","article-title":"The risk of neuroleptic discontinuation in schizophrenia","volume":"33","author":"Jarema","year":"1999","journal-title":"Psychiatr. Pol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib1210","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jocn.2013.10.041","article-title":"Meta-analysis of the efficacy and safety of long-acting non-ergot dopamine agonists in Parkinson\u2019s disease","volume":"21","author":"Zhou","year":"2014","journal-title":"J. Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1215","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10620-018-4937-3","article-title":"Prevalence of nausea and vomiting in adults using ropinirole: a systematic review and meta-analysis","volume":"63","author":"Kurin","year":"2018","journal-title":"Dig. Dis. Sci."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1220","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.parkreldis.2012.01.001","article-title":"Apomorphine injections: predictors of initial common adverse events and long term tolerability","volume":"18","author":"Ondo","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib1225","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1001\/archneur.58.9.1385","article-title":"A randomized, double-blind, placebo-controlled trial of subcutaneously injected apomorphine for parkinsonian off-state events","volume":"58","author":"Dewey","year":"2001","journal-title":"Arch. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2020.105124_bib1230","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jns.2007.03.013","article-title":"Subcutaneous apomorphine in patients with advanced Parkinson\u2019s disease: a dose-escalation study with randomized, double-blind, placebo-controlled crossover evaluation of a single dose","volume":"258","author":"Pahwa","year":"2007","journal-title":"J. Neurol. Sci."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1235","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.parkreldis.2006.06.012","article-title":"Continued efficacy and safety of subcutaneous apomorphine in patients with advanced Parkinson\u2019s disease","volume":"13","author":"Pfeiffer","year":"2007","journal-title":"Parkinsonism Relat. Disord."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1240","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/jnnp.65.5.709","article-title":"Subcutaneous apomorphine in late stage Parkinson\u2019s disease: a long term follow up","volume":"65","author":"Pietz","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib1245","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/mol.117.110890","article-title":"Biased agonism in drug discovery-is it too soon to choose a path?","volume":"93","author":"Michel","year":"2018","journal-title":"Mol. Pharmacol."},{"issue":"22","key":"10.1016\/j.phrs.2020.105124_bib1250","doi-asserted-by":"crossref","first-page":"9841","DOI":"10.1021\/acs.jmedchem.8b00435","article-title":"Biased ligands of g protein-coupled receptors (GPCRs): structure-functional selectivity relationships (SFSRs) and therapeutic potential","volume":"61","author":"Tan","year":"2018","journal-title":"J. Med. Chem."},{"issue":"45","key":"10.1016\/j.phrs.2020.105124_bib1255","doi-asserted-by":"crossref","first-page":"18488","DOI":"10.1073\/pnas.1104807108","article-title":"Discovery of beta-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy","volume":"108","author":"Allen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.106.104463","article-title":"Functional selectivity and classical concepts of quantitative pharmacology","volume":"320","author":"Urban","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"50","key":"10.1016\/j.phrs.2020.105124_bib1265","doi-asserted-by":"crossref","first-page":"E8178","DOI":"10.1073\/pnas.1614347113","article-title":"Distinct cortical and striatal actions of a beta-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties","volume":"113","author":"Urs","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1270","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2165\/00003495-199243030-00002","article-title":"Pharmacological agents affecting emesis. A review (Part I)","volume":"43","author":"Mitchelson","year":"1992","journal-title":"Drugs"},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1275","doi-asserted-by":"crossref","first-page":"352","DOI":"10.7326\/0003-4819-95-3-352","article-title":"The control of chemotherapy-induced emesis","volume":"95","author":"Seigel","year":"1981","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.phrs.2020.105124_bib1280","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.neuro.28.061604.135722","article-title":"Multiple dopamine functions at different time courses","volume":"30","author":"Schultz","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.phrs.2020.105124_bib1285","first-page":"269","article-title":"Phenothiazines and Azaphenothiazines as drugs","volume":"5","author":"Schenker","year":"1963","journal-title":"Fortschr. Arzneimittelforsch."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1290","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archneur.61.5.641","article-title":"The neurobiology of dopamine signaling","volume":"61","author":"Girault","year":"2004","journal-title":"Arch. Neurol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1295","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF03013781","article-title":"Comparison of droperidol, haloperidol and prochlorperazine as postoperative anti-emetics","volume":"26","author":"Loeser","year":"1979","journal-title":"Can. Anaesth. Soc. J."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib1300","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/bja\/58.8.879","article-title":"Comparison of the use of domperidone, droperidol and metoclopramide in the prevention of nausea and vomiting following gynaecological surgery in day cases","volume":"58","author":"Madej","year":"1986","journal-title":"Br. J. Anaesth."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1305","first-page":"38","article-title":"Influence of hippophae rhamnoides on two appetite factors, gastric emptying and metabolic parameters, in children with functional dyspepsia","volume":"16","author":"Xiao","year":"2013","journal-title":"Hell. J. Nucl. Med."},{"issue":"48","key":"10.1016\/j.phrs.2020.105124_bib1310","doi-asserted-by":"crossref","first-page":"7371","DOI":"10.3748\/wjg.v18.i48.7371","article-title":"Itopride therapy for functional dyspepsia: a meta-analysis","volume":"18","author":"Huang","year":"2012","journal-title":"World J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib1315","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1111\/j.1572-0241.2007.01255.x","article-title":"Domperidone: review of pharmacology and clinical applications in gastroenterology","volume":"102","author":"Reddymasu","year":"2007","journal-title":"Am. J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1320","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2165\/00003495-198325050-00002","article-title":"Metoclopramide. An updated review of its pharmacological properties and clinical use","volume":"25","author":"Harrington","year":"1983","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib1325","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0014-2999(79)90275-9","article-title":"Sulpiride blocks the action of dopamine in the rat substantia nigra","volume":"56","author":"Pinnock","year":"1979","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1330","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00569723","article-title":"Metoclopramide and sulpiride as selective blocking agents of pre- and postsynaptic dopamine receptors","volume":"312","author":"Alander","year":"1980","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"12","key":"10.1016\/j.phrs.2020.105124_bib1335","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1021\/jm00150a015","article-title":"Substituted benzamides with conformationally restricted side chains. 1. Quinolizidine derivatives as selective gastric prokinetic agents","volume":"28","author":"Hadley","year":"1985","journal-title":"J. Med. Chem."},{"issue":"7 Suppl 1","key":"10.1016\/j.phrs.2020.105124_bib1340","doi-asserted-by":"crossref","first-page":"46S","DOI":"10.1093\/bja\/69.supplement_1.46S","article-title":"Current management of postoperative nausea and vomiting","volume":"69","author":"Rowbotham","year":"1992","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1345","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/bcp.13128","article-title":"Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects","volume":"83","author":"Taubel","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1350","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00213-009-1521-8","article-title":"Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo","volume":"205","author":"Abbas","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1355","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/bja\/aet251","article-title":"I.V. APD421 (amisulpride) prevents postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled, multicentre trial","volume":"111","author":"Kranke","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.phrs.2020.105124_bib1360","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104603","article-title":"The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva)","volume":"132","author":"Zhong","year":"2020","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1365","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s40263-014-0221-z","article-title":"Role of apomorphine in the treatment of Parkinson\u2019s disease","volume":"29","author":"Boyle","year":"2015","journal-title":"CNS Drugs"},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1370","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0169-409X(98)00033-7","article-title":"An integrated pharmacokinetic-pharmacodynamic approach to optimization of R-apomorphine delivery in Parkinson\u2019s disease","volume":"33","author":"Bodde","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1375","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1124\/jpet.301.3.1166","article-title":"Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase","volume":"301","author":"Mottola","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib1380","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1358\/mf.1999.21.7.550110","article-title":"Behavioral profile of quinpirole in agonistic encounters between male mice","volume":"21","author":"Navarro","year":"1999","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"issue":"10","key":"10.1016\/j.phrs.2020.105124_bib1385","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1038\/sj.npp.1300483","article-title":"Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats","volume":"29","author":"Culm","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib1390","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.clinthera.2006.08.004","article-title":"A review of the receptor-binding and pharmacokinetic properties of dopamine agonists","volume":"28","author":"Kvernmo","year":"2006","journal-title":"Clin. Ther."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1395","first-page":"141","article-title":"Pharmacology of pramipexole, a dopamine D3- preferring agonist useful in treating Parkinson\u2019s disease","volume":"21","author":"Piercey","year":"1998","journal-title":"Clin. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1400","first-page":"35","article-title":"Pramipexole in restless legs syndrome: an evidence-based review of its effectiveness on clinical outcomes","volume":"1","author":"Winlow","year":"2005","journal-title":"Core Evid."},{"issue":"7","key":"10.1016\/j.phrs.2020.105124_bib1405","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.sleep.2007.11.020","article-title":"Meta-analysis of the efficacy and tolerability of pramipexole versus ropinirole in the treatment of restless legs syndrome","volume":"9","author":"Quilici","year":"2008","journal-title":"Sleep Med."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib1410","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/bph.12988","article-title":"Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors","volume":"172","author":"Wood","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1415","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00210-008-0341-4","article-title":"The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson\u2019s disease","volume":"379","author":"Scheller","year":"2009","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib1420","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1358\/dot.2009.45.9.1399952","article-title":"Rotigotine for restless legs syndrome","volume":"45","author":"Davies","year":"2009","journal-title":"Drugs Today (Barc)"},{"issue":"12","key":"10.1016\/j.phrs.2020.105124_bib1425","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1592\/phco.29.12.1452","article-title":"Transdermal rotigotine: a clinically innovative dopamine-receptor agonist for the management of Parkinson\u2019s disease","volume":"29","author":"Chen","year":"2009","journal-title":"Pharmacotherapy"},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib1430","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2165\/00023210-200519110-00006","article-title":"Rotigotine: in Parkinson\u2019s disease","volume":"19","author":"Reynolds","year":"2005","journal-title":"CNS Drugs"},{"issue":"11","key":"10.1016\/j.phrs.2020.105124_bib1435","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00003072-197811000-00013","article-title":"Splenic cysts demonstrated on radionuclide angiogram","volume":"3","author":"Moinuddin","year":"1978","journal-title":"Clin. Nucl. Med."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1440","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.tjog.2018.10.011","article-title":"Effects of silymarin, cabergoline and letrozole on rat model of endometriosis","volume":"57","author":"Jouhari","year":"2018","journal-title":"Taiwan. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1445","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2165\/00003495-199549020-00009","article-title":"Cabergoline. A review of its pharmacological properties and therapeutic potential in the treatment of hyperprolactinaemia and inhibition of lactation","volume":"49","author":"Rains","year":"1995","journal-title":"Drugs"},{"issue":"13","key":"10.1016\/j.phrs.2020.105124_bib1450","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/0024-3205(91)90074-L","article-title":"Pergolide: a dopamine agonist at both D1 and D2 receptors","volume":"49","author":"Fuller","year":"1991","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1455","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ana.410120305","article-title":"Pergolide in late-stage Parkinson disease","volume":"12","author":"Lang","year":"1982","journal-title":"Ann. Neurol."},{"issue":"12","key":"10.1016\/j.phrs.2020.105124_bib1460","article-title":"Aripiprazole alone or in combination for acute mania","author":"Brown","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1465","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/pr.110.002642","article-title":"The physiology, signaling, and pharmacology of dopamine receptors","volume":"63","author":"Beaulieu","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phrs.2020.105124_bib1470","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12888-015-0504-z","article-title":"Aripiprazole for the treatment of tic disorders in children: a systematic review and meta-analysis","volume":"15","author":"Yang","year":"2015","journal-title":"BMC Psychiatry"},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1475","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1517\/13543784.16.6.771","article-title":"Aripiprazole acts as a selective dopamine D2 receptor partial agonist","volume":"16","author":"Wood","year":"2007","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.phrs.2020.105124_bib1480","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/PHMT.S87121","article-title":"Safety and efficacy of aripiprazole for the treatment of pediatric Tourette syndrome and other chronic tic disorders","volume":"7","author":"Cox","year":"2016","journal-title":"Pediatric Health Med. Ther."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1485","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2515\/therapie\/2015036","article-title":"Severe quetiapine withdrawal syndrome with nausea and vomiting in a 65-year-old patient with psychotic depression","volume":"70","author":"Koch","year":"2015","journal-title":"Therapie"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1490","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0006-3223(97)00030-9","article-title":"Antipsychotic properties of the partial dopamine agonist (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine (preclamol) in schizophrenia","volume":"43","author":"Lahti","year":"1998","journal-title":"Biol. Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.phrs.2020.105124_bib1495","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejphar.2005.02.051","article-title":"Aripiprazole\u2019s low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic","volume":"515","author":"Tadori","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2020.105124_bib1500","first-page":"1571","article-title":"The effects of additional treatment with terguride, a partial dopamine agonist, on hyperprolactinemia induced by antipsychotics in schizophrenia patients: a preliminary study","volume":"10","author":"Hashimoto","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1505","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbr.2009.03.037","article-title":"Co-administration of the partial dopamine D2 agonist terguride with L-dopa attenuates L-dopa-induced locomotor sensitization in hemiparkinsonian mice","volume":"202","author":"Kalda","year":"2009","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1510","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/art.25062","article-title":"Evaluation of the efficacy and safety of terguride in patients with fibromyalgia syndrome: results of a twelve-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study","volume":"62","author":"Distler","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1515","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF00450549","article-title":"Terguride in parkinsonism. A multicenter trial","volume":"237","author":"Filipova","year":"1988","journal-title":"Eur. Arch. Psychiatry Neurol. Sci."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib1520","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/jm00060a015","article-title":"Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives","volume":"36","author":"Lin","year":"1993","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1525","article-title":"Chlorpromazine versus placebo for schizophrenia","author":"Adams","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.phrs.2020.105124_bib1530","article-title":"Chlorpromazine dose for people with schizophrenia","volume":"4","author":"Dudley","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1535","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1001\/archinte.1955.00250170100015","article-title":"Control of nausea and vomiting with chlorpromazine; incidence of side-effects","volume":"96","author":"Stephen","year":"1955","journal-title":"AMA Arch. Intern. Med."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1540","first-page":"292","article-title":"Clinical uses of chlorpromazine in veterinary medicine","volume":"128","author":"Estrada","year":"1956","journal-title":"J. Am. Vet. Med. Assoc."},{"issue":"8","key":"10.1016\/j.phrs.2020.105124_bib1545","article-title":"Fluphenazine versus low-potency first-generation antipsychotic drugs for schizophrenia","author":"Tardy","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.phrs.2020.105124_bib1550","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0022-3565(25)25952-3","article-title":"Antiemetic action of fluphenazine (Prolixin): a comparison with other phenothiazines","volume":"131","author":"Laffan","year":"1961","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1555","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.130","article-title":"Pharmacokinetic study of metopimazine by oral route in children","volume":"3","author":"Mallet","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"issue":"12","key":"10.1016\/j.phrs.2020.105124_bib1560","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/EJA.0b013e32833b7969","article-title":"Efficacy of perphenazine to prevent postoperative nausea and vomiting: a quantitative systematic review","volume":"27","author":"Schnabel","year":"2010","journal-title":"Eur. J. Anaesthesiol."},{"key":"10.1016\/j.phrs.2020.105124_bib1565","series-title":"Prochlorperazine","author":"Din","year":"2020"},{"key":"10.1016\/j.phrs.2020.105124_bib1570","series-title":"Antipsychotic Medications","author":"Chokhawala","year":"2020"},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1575","first-page":"137","article-title":"Dopamine receptor antagonists","volume":"1","author":"Smith","year":"2012","journal-title":"Ann. Palliat. Med."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1580","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jopan.2014.01.009","article-title":"A comparison of two differing doses of promethazine for the treatment of postoperative nausea and vomiting","volume":"30","author":"Deitrick","year":"2015","journal-title":"J. Perianesth. Nurs."},{"issue":"4","key":"10.1016\/j.phrs.2020.105124_bib1585","doi-asserted-by":"crossref","DOI":"10.5812\/aapm.57810","article-title":"Comparison effect of promethazine\/dexamethasone and metoclopramide\/dexamethasone on postoperative nausea and vomiting after laparascopic gastric placation: a randomized clinical trial","volume":"7","author":"Talebpour","year":"2017","journal-title":"Anesth. Pain Med."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1590","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/1043-6618(91)90070-E","article-title":"Pretreatment with bendazac attenuates retinal damage induced by intense light in rats","volume":"24","author":"Scorza Barcellona","year":"1991","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1595","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/01.pra.0000351878.45260.94","article-title":"Use and safety of antipsychotic drugs during pregnancy","volume":"15","author":"Einarson","year":"2009","journal-title":"J. Psychiatry Pract."},{"key":"10.1016\/j.phrs.2020.105124_bib1600","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.reprotox.2019.06.002","article-title":"The effect of anti-emetic drugs on rat embryonic heart activity","volume":"87","author":"Ritchie","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.phrs.2020.105124_bib1605","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF03002087","article-title":"The effectiveness of anti-emetic agents: a comparison of the anti-emetic activity of trifluopromazine (vesprin), perphenazine (trilafon), and trifluoperazine (stelazine) with that of dimenhydrinate (gravol) in postanesthetic vomiting","volume":"10","author":"Purkis","year":"1963","journal-title":"Can. Anaesth. Soc. J."},{"issue":"29","key":"10.1016\/j.phrs.2020.105124_bib1610","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.2174\/1568026616666160608084834","article-title":"Dopamine targeting drugs for the treatment of schizophrenia: past, present and future","volume":"16","author":"Li","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1615","article-title":"Benperidol for schizophrenia","author":"Leucht","year":"2005","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1620","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12868-017-0394-8","article-title":"In silico repurposing of antipsychotic drugs for Alzheimer\u2019s disease","volume":"18","author":"Kumar","year":"2017","journal-title":"BMC Neurosci."},{"issue":"12","key":"10.1016\/j.phrs.2020.105124_bib1625","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1176\/ajp.137.12.1518","article-title":"Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency","volume":"137","author":"Peroutka","year":"1980","journal-title":"Am. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1630","first-page":"1","article-title":"Evidence-based review and appraisal of the use of droperidol in the emergency department","volume":"30","author":"Lai","year":"2018","journal-title":"Ci Ji Yi Xue Za Zhi"},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1635","first-page":"857","article-title":"Long-term use of intrathecal droperidol as an excellent antiemetic in nonmalignant pain\u2013a retrospective study","volume":"21","author":"Ahmad-Sabry","year":"2012","journal-title":"Middle East J. Anaesthesiol."},{"key":"10.1016\/j.phrs.2020.105124_bib1640","series-title":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury","author":"Antipsychotic Agents","year":"2012"},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1645","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1097\/00000542-200412000-00028","article-title":"Is low-dose haloperidol a useful antiemetic?: A meta-analysis of published and unpublished randomized trials","volume":"101","author":"Buttner","year":"2004","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1650","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0022-3565(25)04467-2","article-title":"The anti-emetic activity of 10-(gamma-dimethylaminopropyl)-2-chlorophenothiazine (chlorpromazine) in dog and cat","volume":"110","author":"Brand","year":"1954","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1655","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/2045125311399800","article-title":"Melperone in treatment-refractory schizophrenia: a case series","volume":"1","author":"Whiskey","year":"2011","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"10.1016\/j.phrs.2020.105124_bib1660","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/512047","article-title":"Auditing clinical outcomes after introducing off-licence prescribing of atypical antipsychotic melperone for patients with treatment refractory schizophrenia","volume":"2012","author":"Rohricht","year":"2012","journal-title":"ScientificWorldJournal"},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1665","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0165-1781(01)00346-8","article-title":"Melperone in the treatment of neuroleptic-resistant schizophrenia","volume":"105","author":"Meltzer","year":"2001","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1670","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000118074","article-title":"Melperone in low doses in anxious neurotic patients. A double-blind placebo-controlled clinical study","volume":"11","author":"Poldinger","year":"1984","journal-title":"Neuropsychobiology"},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1675","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0022-3565(24)36394-3","article-title":"Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2\/D3 dopamine receptor antagonist activity and limbic selectivity","volume":"280","author":"Perrault","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1680","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/ALN.0000000000002133","article-title":"Amisulpride prevents postoperative nausea and vomiting in patients at high risk: a randomized, double-blind, placebo-controlled trial","volume":"128","author":"Kranke","year":"2018","journal-title":"Anesthesiology"},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1685","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1590\/S0102-86502012000600003","article-title":"Effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis","volume":"27","author":"Silva","year":"2012","journal-title":"Acta Cir. Bras."},{"issue":"6","key":"10.1016\/j.phrs.2020.105124_bib1690","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1528-1157.1986.tb03595.x","article-title":"Dicarboxylic amino acids block epileptiform activity in hippocampal slice","volume":"27","author":"ffrench-Mullen","year":"1986","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1695","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/BF02336697","article-title":"Phase I-trial of clebopride, a new antiemetic, in chemotherapy\u2013induced nausea and vomiting","volume":"38","author":"Lenz","year":"1990","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1700","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1124\/jpet.110.174847","article-title":"Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride","volume":"336","author":"Matsunaga","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2020.105124_bib1705","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2036.2010.04487.x","article-title":"The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man","volume":"33","author":"Scarpellini","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.phrs.2020.105124_bib1710","first-page":"353","article-title":"Pharmacokinetic basis for predicting steady-state serum drug concentrations of imipramine from single dose data","volume":"3","author":"DeVane","year":"1979","journal-title":"Commun. Psychopharmacol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105124_bib1715","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/aps.2017.24","article-title":"Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer","volume":"38","author":"Li","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phrs.2020.105124_bib1720","first-page":"30","article-title":"The system of cyclic nucleotides in the growth regulation of cerebral tumors in the young","volume":"18","author":"Kumakura","year":"1976","journal-title":"Mod. Probl. Paediatr."},{"issue":"12","key":"10.1016\/j.phrs.2020.105124_bib1725","first-page":"855","article-title":"Antiemetic properties of levo-sulpiride","volume":"81","author":"Guslandi","year":"1990","journal-title":"Minerva Med."},{"key":"10.1016\/j.phrs.2020.105124_bib1730","first-page":"43","article-title":"Neurotransmitter receptor imaging in Alzheimer\u2019s disease","volume":"24","author":"Sedvall","year":"1987","journal-title":"J. Neural Transm. Suppl."},{"issue":"3","key":"10.1016\/j.phrs.2020.105124_bib1735","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1527-3458.2001.tb00199.x","article-title":"Pharmacology of the atypical antipsychotic remoxipride, a dopamine D2 receptor antagonist","volume":"7","author":"Nadal","year":"2001","journal-title":"CNS Drug Rev."},{"issue":"2","key":"10.1016\/j.phrs.2020.105124_bib1740","first-page":"109","article-title":"Tiapride versus metoclopramide: comparison after minor gynaecological surgery","volume":"10","author":"Joshi","year":"1993","journal-title":"Eur. J. Anaesthesiol."},{"issue":"Suppl. 1","key":"10.1016\/j.phrs.2020.105124_bib1745","doi-asserted-by":"crossref","first-page":"29s","DOI":"10.1016\/S0924-9338(00)00526-5","article-title":"The preclinical pharmacologic profile of tiapride","volume":"16","author":"Scatton","year":"2001","journal-title":"Eur. Psychiatry"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820314328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820314328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:23:54Z","timestamp":1760912634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661820314328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":349,"alternative-id":["S1043661820314328"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105124","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dopamine receptors in emesis: Molecular mechanisms and potential therapeutic function","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105124"}}