{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:46:46Z","timestamp":1784090806238,"version":"3.55.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017170","name":"Thailand Science Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.phrs.2020.105239","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T17:32:20Z","timestamp":1602437540000},"page":"105239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Myeloid differentiation factor 2 in the heart: Bench to bedside evidence for potential clinical benefits?"],"prefix":"10.1016","volume":"163","author":[{"given":"Natticha","family":"Sumneang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattayaporn","family":"Apaijai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C.","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10106","key":"10.1016\/j.phrs.2020.105239_bib0005","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/S0140-6736(17)31071-1","article-title":"Heart failure","volume":"390","author":"Metra","year":"2017","journal-title":"Lancet"},{"issue":"16","key":"10.1016\/j.phrs.2020.105239_bib0010","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phrs.2020.105239_bib0015","doi-asserted-by":"crossref","first-page":"9874109","DOI":"10.1155\/2018\/9874109","article-title":"The role of toll-like receptor signaling in the progression of heart failure","volume":"2018","author":"Yu","year":"2018","journal-title":"Mediators Inflamm."},{"issue":"11","key":"10.1016\/j.phrs.2020.105239_bib0020","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.tem.2013.06.004","article-title":"Translation of hemodynamic stress to sterile inflammation in the heart","volume":"24","author":"Nakayama","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.phrs.2020.105239_bib0025","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/157340309788970405","article-title":"Toll-like receptors and myocardial ischemia\/reperfusion, inflammation, and injury","volume":"5","author":"Kaczorowski","year":"2009","journal-title":"Curr. Cardiol. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2020.105239_bib0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00395-016-0599-5","article-title":"MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4\/NF-kappaB signaling pathway","volume":"112","author":"Han","year":"2017","journal-title":"Basic Res. Cardiol."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165683","article-title":"Arachidonic acid inhibits inflammatory responses by binding to myeloid differentiation factor-2 (MD2) and preventing MD2\/toll-like receptor 4 signaling activation","volume":"1866","author":"Zhang","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"4","key":"10.1016\/j.phrs.2020.105239_bib0040","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1056\/NEJM199007263230405","article-title":"Elevated circulating levels of tumor necrosis factor in severe chronic heart failure","volume":"323","author":"Levine","year":"1990","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.phrs.2020.105239_bib0045","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1527-5299.2006.05595.x","article-title":"Inflammatory biomarkers in heart failure","volume":"12","author":"Petersen","year":"2006","journal-title":"Congest. Heart Fail."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0050","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1253\/circj.CJ-17-0261","article-title":"Sterile inflammation and degradation systems in heart failure","volume":"81","author":"Nishida","year":"2017","journal-title":"Circ. J."},{"issue":"3","key":"10.1016\/j.phrs.2020.105239_bib0055","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/acel.12581","article-title":"Pathophysiology of heart failure and frailty: a common inflammatory origin?","volume":"16","author":"Bellumkonda","year":"2017","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.phrs.2020.105239_bib0060","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.bbadis.2017.09.026","article-title":"Inhibition of myeloid differentiation factor-2 attenuates obesity-induced cardiomyopathy and fibrosis","volume":"1864","author":"Fang","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.phrs.2020.105239_bib0065","doi-asserted-by":"crossref","first-page":"13997","DOI":"10.1038\/ncomms13997","article-title":"Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2020.105239_bib0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.taap.2017.11.003","article-title":"An anti-inflammatory chalcone derivative prevents heart and kidney from hyperlipidemia-induced injuries by attenuating inflammation","volume":"338","author":"Chen","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105239_bib0075","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/infdis\/jiq155","article-title":"MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity","volume":"203","author":"Roh","year":"2011","journal-title":"J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.phrs.2020.105239_bib0080","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1189\/jlb.1206727","article-title":"MD-2 as the target of curcumin in the inhibition of response to LPS","volume":"82","author":"Gradisar","year":"2007","journal-title":"J. Leukoc. Biol."},{"issue":"14","key":"10.1016\/j.phrs.2020.105239_bib0085","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1055\/s-0029-1241013","article-title":"Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2)","volume":"76","author":"Peluso","year":"2010","journal-title":"Planta Med."},{"issue":"8","key":"10.1016\/j.phrs.2020.105239_bib0090","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1111\/bph.12091","article-title":"Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2","volume":"168","author":"Kim","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"17","key":"10.1016\/j.phrs.2020.105239_bib0095","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1111\/bph.13221","article-title":"MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis","volume":"172","author":"Wang","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105239_bib0100","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1194\/jlr.D029546","article-title":"Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways","volume":"53","author":"Huang","year":"2012","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.phrs.2020.105239_bib0105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2567.2008.02892.x","article-title":"Fatty acid-induced induction of Toll-like receptor-4\/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity","volume":"126","author":"Schaeffler","year":"2009","journal-title":"Immunology"},{"issue":"11","key":"10.1016\/j.phrs.2020.105239_bib0110","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1161\/CIRCRESAHA.106.142851","article-title":"Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity","volume":"100","author":"Kim","year":"2007","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.phrs.2020.105239_bib0115","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2012.01.023","article-title":"Saturated fatty acid and TLR signaling link \u03b2 cell dysfunction and islet inflammation","volume":"15","author":"Eguchi","year":"2012","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.phrs.2020.105239_bib0120","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/vaccines5040034","article-title":"TLR4 signaling pathway modulators as potential therapeutics in inflammation and Sepsis","volume":"5","author":"Kuzmich","year":"2017","journal-title":"Vaccines (Basel)"},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/09680519000060050101","article-title":"Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes","volume":"6","author":"Dziarski","year":"2000","journal-title":"J. Endotoxin Res."},{"issue":"11","key":"10.1016\/j.phrs.2020.105239_bib0130","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.189.11.1777","article-title":"MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4","volume":"189","author":"Shimazu","year":"1999","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.phrs.2020.105239_bib0135","doi-asserted-by":"crossref","first-page":"G433","DOI":"10.1152\/ajpgi.00163.2009","article-title":"Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice","volume":"300","author":"Csak","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105239_bib0140","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ni809","article-title":"Essential role of MD-2 in LPS responsiveness and TLR4 distribution","volume":"3","author":"Nagai","year":"2002","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105239_bib0145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5483\/BMBRep.2017.50.2.011","article-title":"Dynamic lipopolysaccharide transfer cascade to TLR4\/MD2 complex via LBP and CD14","volume":"50","author":"Kim","year":"2017","journal-title":"BMB Rep."},{"issue":"20","key":"10.1016\/j.phrs.2020.105239_bib0150","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1161\/01.CIR.0000038110.69369.4C","article-title":"CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction","volume":"106","author":"Knuefermann","year":"2002","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.phrs.2020.105239_bib0155","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrmicro3047","article-title":"Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis","volume":"11","author":"Needham","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105239_bib0160","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2009.08.062","article-title":"Toll-like receptors and innate immunity","volume":"388","author":"Kumar","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2020.105239_bib0165","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2020.105239_bib0170","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-1-4419-1603-7_6","article-title":"Lipid A receptor TLR4-mediated signaling pathways","volume":"667","author":"Yamamoto","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105239_bib0175","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrmicro3047","article-title":"Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis","volume":"11","author":"Needham","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105239_bib0180","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/IAI.00890-12","article-title":"TRIF mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferi","volume":"81","author":"Petnicki-Ocwieja","year":"2013","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0185","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.phrs.2020.105239_bib0190","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0021-9258(17)35666-1","article-title":"Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix","volume":"261","author":"Ignotz","year":"1986","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0195","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/08977194.2011.595714","article-title":"TGF-\u03b2 signaling in fibrosis","volume":"29","author":"Biernacka","year":"2011","journal-title":"Growth Factors"},{"issue":"2","key":"10.1016\/j.phrs.2020.105239_bib0200","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.krcp.2012.04.322","article-title":"TGF-\u03b2-activated kinase-1: new insights into the mechanism of TGF-\u03b2 signaling and kidney disease","volume":"31","author":"Kim","year":"2012","journal-title":"Kidney Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.phrs.2020.105239_bib0205","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/celldisc.2017.23","article-title":"TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis","volume":"3","author":"Li","year":"2017","journal-title":"Cell Discov."},{"issue":"7","key":"10.1016\/j.phrs.2020.105239_bib0210","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1681\/ASN.2010040384","article-title":"Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis","volume":"22","author":"R\u00fcster","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105239_bib0215","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4239\/wjd.v4.i4.101","article-title":"Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures","volume":"4","author":"Roy","year":"2013","journal-title":"World J. Diabetes"},{"issue":"17","key":"10.1016\/j.phrs.2020.105239_bib0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174112","article-title":"TNF-\u03b1 in combination with palmitate enhances IL-8 production via the MyD88- independent TLR4 signaling pathway: potential relevance to metabolic inflammation","volume":"20","author":"Hasan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0225","doi-asserted-by":"crossref","first-page":"E780","DOI":"10.1152\/ajpendo.00187.2018","article-title":"Is palmitate truly proinflammatory? Experimental confounders and context-specificity","volume":"315","author":"Ono-Moore","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0230","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cell.2019.03.018","article-title":"Metabolic and innate immune cues merge into a specific inflammatory response via the UPR","volume":"177","author":"Mogilenko","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2020.105239_bib0235","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1038\/s41598-018-23539-4","article-title":"Interleukin-23 as a therapeutic target for inflammatory myopathy","volume":"8","author":"Umezawa","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.phrs.2020.105239_bib0240","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.jacc.2003.07.021","article-title":"Attenuation of virus-induced myocardial injury by inhibition of the angiotensin II type 1 receptor signal and decreased nuclear factor-kappa B activation in knockout mice","volume":"42","author":"Yamamoto","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/j.phrs.2020.105239_bib0245","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97054","article-title":"CaMKII\u03b4-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis","volume":"3","author":"Willeford","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.phrs.2020.105239_bib0250","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ijcard.2018.06.025","article-title":"MD-2 is a new predictive biomarker in dilated cardiomyopathy and exerts direct effects in isolated cardiomyocytes","volume":"270","author":"Riad","year":"2018","journal-title":"Int. J. Cardiol."},{"issue":"11","key":"10.1016\/j.phrs.2020.105239_bib0255","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/glycob\/cwx075","article-title":"Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling","volume":"27","author":"Iijima","year":"2017","journal-title":"Glycobiology"},{"key":"10.1016\/j.phrs.2020.105239_bib0260","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/bs.acr.2014.11.006","article-title":"Functional impact of tumor-specific N-linked glycan changes in breast and ovarian cancers","volume":"126","author":"Guo","year":"2015","journal-title":"Adv. Cancer Res."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0265","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1464-410X.1989.tb05275.x","article-title":"Risk factors for urinary calcium oxalate crystals as revealed by their specific enzymatic assay","volume":"64","author":"Hallson","year":"1989","journal-title":"Br. J. Urol."},{"key":"10.1016\/j.phrs.2020.105239_bib0270","article-title":"Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88","author":"Yang","year":"2020","journal-title":"Innate Immun."},{"issue":"4","key":"10.1016\/j.phrs.2020.105239_bib0275","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1007\/s10753-019-01174-z","article-title":"Protective effect of a novel (2S, 3R, 4S)-Chromene-3-Carboxamide derivative, Z20 against sepsis-induced organ injury","volume":"43","author":"Zeng","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.phrs.2020.105239_bib0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115811","article-title":"Inhibitory effect of porphyran on lipopolysaccharide-induced activation of human immune cells","volume":"232","author":"Wang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phrs.2020.105239_bib0285","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ijbiomac.2020.05.169","article-title":"Naja kaouthia venom protein, Nk-CRISP, upregulates inflammatory gene expression in human macrophages","volume":"160","author":"Deka","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"11","key":"10.1016\/j.phrs.2020.105239_bib0290","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1039\/c1ib00008j","article-title":"An extended bioreaction database that significantly improves reconstruction and analysis of genome-scale metabolic networks","volume":"3","author":"Stelzer","year":"2011","journal-title":"Integr. Biol. (Camb)"},{"key":"10.1016\/j.phrs.2020.105239_bib0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102706","article-title":"Macrophage-derived myeloid differentiation protein 2 plays an essential role in ox-LDL-induced inflammation and atherosclerosis","volume":"53","author":"Chen","year":"2020","journal-title":"EBioMedicine"},{"issue":"7","key":"10.1016\/j.phrs.2020.105239_bib0300","doi-asserted-by":"crossref","first-page":"E884","DOI":"10.1073\/pnas.1525639113","article-title":"TLR4\/MD-2 activation by a synthetic agonist with no similarity to LPS","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.phrs.2020.105239_bib0305","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/ATVBAHA.115.305789","article-title":"HMGB1-driven inflammation and intimal hyperplasia after arterial injury involves cell-specific actions mediated by TLR4","volume":"35","author":"Cai","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"10","key":"10.1016\/j.phrs.2020.105239_bib0310","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41584-018-0077-6","article-title":"Targeting the TLR4-MD2 axis in systemic sclerosis","volume":"14","author":"O\u2019Reilly","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0315","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s00395-014-0428-7","article-title":"Cardiac fibroblasts support cardiac inflammation in heart failure","volume":"109","author":"Lindner","year":"2014","journal-title":"Basic Res. Cardiol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105239_bib0320","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1161\/ATVBAHA.112.251181","article-title":"Toll-like receptor 4 activation in microvascular endothelial cells triggers a robust inflammatory response and cross talk with mononuclear cells via interleukin-6","volume":"32","author":"Lu","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105239_bib0325","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007849","article-title":"Role of monocytes in heart failure and Atrial Fibrillation","volume":"7","author":"Shahid","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0330","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2796.2008.01989.x","article-title":"Aspirin and clopidogrel with or without phenprocoumon after drug eluting coronary stent placement in patients on chronic oral anticoagulation","volume":"264","author":"Sarafoff","year":"2008","journal-title":"J. Intern. Med."},{"issue":"6","key":"10.1016\/j.phrs.2020.105239_bib0335","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","article-title":"Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia\/reperfusion injury","volume":"123","author":"Kawaguchi","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.phrs.2020.105239_bib0340","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1476-9255-9-48","article-title":"Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation","volume":"9","author":"Ahmad","year":"2012","journal-title":"J. Inflamm. (Lond)"},{"issue":"1","key":"10.1016\/j.phrs.2020.105239_bib0345","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ddr.21607","article-title":"L6H9 attenuates LPS-induced acute lung injury in rats through targeting MD2","volume":"81","author":"Wu","year":"2020","journal-title":"Drug Dev. Res."},{"issue":"10","key":"10.1016\/j.phrs.2020.105239_bib0350","doi-asserted-by":"crossref","first-page":"18731","DOI":"10.1002\/jcp.28513","article-title":"C1q\/TNF-related protein-9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction","volume":"234","author":"Liu","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.phrs.2020.105239_bib0355","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.phrs.2020.105239_bib0360","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12929-017-0322-3","article-title":"Macrophage activation and polarization in post-infarction cardiac remodeling","volume":"24","author":"Gombozhapova","year":"2017","journal-title":"J. Biomed. Sci."},{"issue":"9","key":"10.1016\/j.phrs.2020.105239_bib0365","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/oby.21916","article-title":"MD2 blockage protects obesity-induced vascular remodeling via activating AMPK\/Nrf2","volume":"25","author":"Wang","year":"2017","journal-title":"Obesity (Silver Spring)"},{"issue":"17","key":"10.1016\/j.phrs.2020.105239_bib0370","doi-asserted-by":"crossref","first-page":"15028","DOI":"10.1074\/jbc.M200497200","article-title":"Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4","volume":"277","author":"Asea","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.phrs.2020.105239_bib0375","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133121","article-title":"Unveiling the interplay between the TLR4\/MD2 complex and HSP70 in the human cardiovascular system: a computational approach","volume":"20","author":"de Oliveira","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.phrs.2020.105239_bib0380","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11883-014-0435-z","article-title":"Inflammation and cardiovascular disease: from pathogenesis to therapeutic target","volume":"16","author":"Golia","year":"2014","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.phrs.2020.105239_bib0385","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9874109","article-title":"The role of toll-like receptor signaling in the progression of heart failure","volume":"2018","author":"Yu","year":"2018","journal-title":"Mediators Inflamm."},{"issue":"2","key":"10.1016\/j.phrs.2020.105239_bib0390","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/1573403X12666160901145313","article-title":"Endotoxin, toll-like receptor-4, and atherosclerotic heart disease","volume":"13","author":"Bowman","year":"2017","journal-title":"Curr. Cardiol. Rev."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820315474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820315474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:25:14Z","timestamp":1760912714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661820315474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":78,"alternative-id":["S1043661820315474"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105239","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myeloid differentiation factor 2 in the heart: Bench to bedside evidence for potential clinical benefits?","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105239"}}