{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:04:29Z","timestamp":1790391869093,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1GM097480"],"award-info":[{"award-number":["RO1GM097480"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.phrs.2020.105272","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T08:57:07Z","timestamp":1604566627000},"page":"105272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Arginine vasopressin receptor 2 activation promotes microvascular permeability in sepsis"],"prefix":"10.1016","volume":"163","author":[{"given":"Ernesto","family":"Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Modis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baigal","family":"Enkhtaivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Trujillo-Abarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Lima-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dannelys","family":"Perez-Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald S.","family":"Prough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perenlei","family":"Enkhbaatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9749","key":"10.1016\/j.phrs.2020.105272_bib0005","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0140-6736(10)60446-1","article-title":"Critical care and the global burden of critical illness in adults","volume":"376","author":"Adhikari","year":"2010","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.phrs.2020.105272_bib0010","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/CCM.0b013e318232db65","article-title":"Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007","volume":"40","author":"Lagu","year":"2012","journal-title":"Crit. Care Med."},{"issue":"7","key":"10.1016\/j.phrs.2020.105272_bib0015","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit. Care Med."},{"issue":"5","key":"10.1016\/j.phrs.2020.105272_bib0020","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1097\/01.CCM.0000260960.94300.DE","article-title":"Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward","volume":"35","author":"Esteban","year":"2007","journal-title":"Crit. Care Med."},{"issue":"2","key":"10.1016\/j.phrs.2020.105272_bib0025","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00134-001-1143-z","article-title":"Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study","volume":"28","author":"Alberti","year":"2002","journal-title":"Intensive Care Med."},{"issue":"6","key":"10.1016\/j.phrs.2020.105272_bib0030","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1586\/eri.12.50","article-title":"Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes","volume":"10","author":"Martin","year":"2012","journal-title":"Expert Rev. Anti. Ther."},{"issue":"3","key":"10.1016\/j.phrs.2020.105272_bib0035","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/joim.12331","article-title":"Endothelial barrier dysfunction in septic shock","volume":"277","author":"Opal","year":"2015","journal-title":"J. Intern. Med."},{"issue":"9","key":"10.1016\/j.phrs.2020.105272_bib0040","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa067373","article-title":"Vasopressin versus norepinephrine infusion in patients with septic shock","volume":"358","author":"Russell","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.phrs.2020.105272_bib0045","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/ACO.0000000000000210","article-title":"Emerging therapies for the treatment of sepsis","volume":"28","author":"Vincent","year":"2015","journal-title":"Curr. Opin. Anaesthesiol."},{"issue":"7","key":"10.1016\/j.phrs.2020.105272_bib0050","doi-asserted-by":"crossref","first-page":"E525","DOI":"10.1097\/CCM.0000000000000300","article-title":"The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe Sepsis","volume":"42","author":"Maybauer","year":"2014","journal-title":"Crit. Care Med."},{"issue":"9","key":"10.1016\/j.phrs.2020.105272_bib0055","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00134-009-1560-y","article-title":"Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality","volume":"35","author":"van der Heijden","year":"2009","journal-title":"Intensive Care Med."},{"issue":"11","key":"10.1016\/j.phrs.2020.105272_bib0060","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1097\/CCM.0000000000001853","article-title":"Elevated plasma Angiopoietin-2 levels are associated with fluid overload, organ dysfunction, and mortality in human septic shock","volume":"44","author":"Fisher","year":"2016","journal-title":"Crit. Care Med."},{"issue":"5","key":"10.1016\/j.phrs.2020.105272_bib0065","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/01.ATV.0000209501.56852.6c","article-title":"Dynamics and plasticity of Weibel-Palade bodies in endothelial cells","volume":"26","author":"Rondaij","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105272_bib0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1172\/JCI9516","article-title":"Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP","volume":"106","author":"Kaufmann","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.phrs.2020.105272_bib0075","doi-asserted-by":"crossref","first-page":"F1005","DOI":"10.1152\/ajprenal.00243.2011","article-title":"Tolvaptan inhibits ERK-dependent cell proliferation, Cl(-) secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin","volume":"301","author":"Reif","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2020.105272_bib0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10549-013-2724-6","article-title":"Reduction of tumor angiogenesis induced by desmopressin in a breast cancer model","volume":"142","author":"Ripoll","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.phrs.2020.105272_bib0085","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40635-019-0227-4","article-title":"Peroxynitrite decomposition catalyst reduces vasopressin requirement in ovine MRSA sepsis","volume":"7","author":"Fujiwara","year":"2019","journal-title":"Intensive Care Med. Exp."},{"issue":"5","key":"10.1016\/j.phrs.2020.105272_bib0090","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1097\/SHK.0b013e318158125b","article-title":"Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis","volume":"29","author":"Enkhbaatar","year":"2008","journal-title":"Shock (Augusta, Ga)"},{"issue":"S3","key":"10.1016\/j.phrs.2020.105272_bib0095","doi-asserted-by":"crossref","DOI":"10.1186\/cc10408","article-title":"Interplay between angiopoietin-2, vascular endothelial growth factor and peroxynitrite is an important determinant of vascular hyperpermeability during methicillin-resistant Staphylococcus aureus sepsis","volume":"15","author":"Enkhbaatar","year":"2011","journal-title":"Crit. Care"},{"issue":"3","key":"10.1016\/j.phrs.2020.105272_bib0100","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bbrc.2008.10.066","article-title":"Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity","volume":"377","author":"Maybauer","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.phrs.2020.105272_bib0105","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1097\/SHK.0000000000001297","article-title":"Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock","volume":"52","author":"Fukuda","year":"2019","journal-title":"Shock"},{"issue":"9","key":"10.1016\/j.phrs.2020.105272_bib0110","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/thoraxjnl-2013-204980","article-title":"Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia","volume":"69","author":"Asmussen","year":"2014","journal-title":"Thorax"},{"issue":"12","key":"10.1016\/j.phrs.2020.105272_bib0115","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1097\/CCM.0b013e3181f8557b","article-title":"Muscarinic receptor antagonist therapy improves acute pulmonary dysfunction after smoke inhalation injury in sheep","volume":"38","author":"Jonkam","year":"2010","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.phrs.2020.105272_bib0120","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9010275","article-title":"Epidemiology, treatment, and prevention of nosocomial bacterial pneumonia","volume":"9","author":"Jean","year":"2020","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.phrs.2020.105272_bib0125","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1097\/CCM.0b013e31824e0fe5","article-title":"Unlike arginine vasopressin, the selective V1a receptor agonist FE 202158 does not cause procoagulant effects by releasing von Willebrand factor","volume":"40","author":"Rehberg","year":"2012","journal-title":"Crit. Care Med."},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2020.105272_bib0130","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1007\/s10557-011-6355-z","article-title":"Anti-edematous effects of tolvaptan in experimental rodent models","volume":"25","author":"Miyazaki","year":"2011","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2020.105272_bib0135","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1007\/s10557-011-6350-4","article-title":"Effects of tolvaptan on systemic and renal hemodynamic function in dogs with congestive heart failure","volume":"25","author":"Onogawa","year":"2011","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"4","key":"10.1016\/j.phrs.2020.105272_bib0140","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/CCM.0b013e318207ec52","article-title":"Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury","volume":"39","author":"Lange","year":"2011","journal-title":"Crit. Care Med."},{"issue":"2","key":"10.1016\/j.phrs.2020.105272_bib0145","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1097\/CCM.0000000000001349","article-title":"Nebulized epinephrine limits pulmonary vascular hyperpermeability to water and protein in ovine with burn and smoke inhalation injury","volume":"44","author":"Lopez","year":"2016","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.phrs.2020.105272_bib0150","doi-asserted-by":"crossref","DOI":"10.1038\/nmeth.f.353","article-title":"The Simple WesternTM: a gel-free, blot-free, hands-free Western blotting reinvention","volume":"8","author":"Nguyen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phrs.2020.105272_bib0155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0076-6879(08)02008-9","article-title":"An assay system for in vitro detection of permeability in human \u201cEndothelium\u201d","volume":"443","author":"Martins-Green","year":"2008","journal-title":"Meth. Enzymol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105272_bib0160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/SHK.0000000000001432","article-title":"Antithrombin III Contributes to the Protective Effects of Fresh Frozen Plasma Following Hemorrhagic Shock by Preventing Syndecan-1 Shedding and Endothelial Barrier Disruption","volume":"53","author":"Lopez","year":"2020","journal-title":"Shock"},{"issue":"5","key":"10.1016\/j.phrs.2020.105272_bib0165","first-page":"749","article-title":"Oxidant-induced cardiomyocyte injury: identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay","volume":"20","author":"Gero","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phrs.2020.105272_bib0170","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v3.24858","article-title":"The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling","volume":"3","author":"Van Deun","year":"2014","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.phrs.2020.105272_bib0175","first-page":"1","article-title":"Nebulized Epinephrine Limits Pulmonary Vascular Hyperpermeability to Water and Protein in Ovine With Burn and Smoke Inhalation Injury","author":"Lopez","year":"2015","journal-title":"Crit. Care Med."},{"issue":"2","key":"10.1016\/j.phrs.2020.105272_bib0180","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.CCM.0000194725.48928.3A","article-title":"Sepsis occurrence in acutely ill patients I. Sepsis in European intensive care units: results of the SOAP study","volume":"34","author":"Vincent","year":"2006","journal-title":"Crit. Care Med."},{"issue":"10","key":"10.1016\/j.phrs.2020.105272_bib0185","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1152\/ajpheart.00390.2012","article-title":"Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis","volume":"303","author":"Rehberg","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phrs.2020.105272_bib0190","article-title":"A selective V1A receptor agonist, Selepressin, is superior to arginine vasopressin and to norepinephrine in ovine septic shock","author":"He","year":"2015","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.phrs.2020.105272_bib0195","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/CIRCHEARTFAILURE.109.916114","article-title":"Renal and anti-aldosterone actions of vasopressin-2 receptor antagonism and B-type natriuretic peptide in experimental heart failure","volume":"3","author":"Costello-Boerrigter","year":"2010","journal-title":"Circ. Heart Fail."},{"issue":"6","key":"10.1016\/j.phrs.2020.105272_bib0200","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jjcc.2012.09.002","article-title":"Short-term effects of low-dose tolvaptan on hemodynamic parameters in patients with chronic heart failure","volume":"60","author":"Watanabe","year":"2012","journal-title":"J. Cardiol."},{"issue":"11","key":"10.1016\/j.phrs.2020.105272_bib0205","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1097\/CCM.0b013e31825fdc31","article-title":"Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*","volume":"40","author":"David","year":"2012","journal-title":"Crit. Care Med."},{"issue":"2","key":"10.1016\/j.phrs.2020.105272_bib0210","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/cc7153","article-title":"Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?","volume":"13","author":"van Meurs","year":"2009","journal-title":"Crit. Care"},{"issue":"2","key":"10.1016\/j.phrs.2020.105272_bib0215","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cyto.2015.02.013","article-title":"Evaluation of endothelial biomarkers as predictors of organ failures in septic shock patients","volume":"73","author":"Palud","year":"2015","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.phrs.2020.105272_bib0220","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00430-013-0310-5","article-title":"Differential regulation of angiopoietin 1 and angiopoietin 2 during dengue virus infection of human umbilical vein endothelial cells: implications for endothelial hyperpermeability","volume":"202","author":"Ong","year":"2013","journal-title":"Med. Microbiol. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105272_bib0225","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1164\/rccm.201708-1733OC","article-title":"Capnetz, dagger PSGd. Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia","volume":"198","author":"Gutbier","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7","key":"10.1016\/j.phrs.2020.105272_bib0230","doi-asserted-by":"crossref","first-page":"e230","DOI":"10.1097\/CCM.0000000000000993","article-title":"Drug repurposing screen identifies Foxo1-Dependent Angiopoietin-2 regulation in Sepsis","volume":"43","author":"Ghosh","year":"2015","journal-title":"Crit. Care Med."},{"issue":"8","key":"10.1016\/j.phrs.2020.105272_bib0235","doi-asserted-by":"crossref","first-page":"650","DOI":"10.2174\/13892037113146660085","article-title":"Structure\/Function relationships of phospholipases C Beta","volume":"14","author":"Sandal","year":"2013","journal-title":"Curr. Protein Pept. Sci."},{"issue":"15","key":"10.1016\/j.phrs.2020.105272_bib0240","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1021\/ac8008548","article-title":"Phosphorylation analysis of G protein-coupled receptor by mass spectrometry: identification of a phosphorylation site in V2 vasopressin receptor","volume":"80","author":"Wu","year":"2008","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.phrs.2020.105272_bib0245","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1073\/pnas.93.7.2827","article-title":"G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein","volume":"93","author":"Zhu","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.phrs.2020.105272_bib0250","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1046\/j.1538-7836.2003.00190.x","article-title":"Cellular mechanisms of the hemostatic effects of desmopressin (DDAVP)","volume":"1","author":"Kaufmann","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.phrs.2020.105272_bib0255","doi-asserted-by":"crossref","DOI":"10.1160\/TH05-02-0092","article-title":"Acute tissue-type plasminogen activator release in human microvascular endothelial cells: The roles of G\u03b1q, PLC-\u03b2, IP3 and 5,6-epoxyeicosatrienoic acid","author":"Muldowney","year":"2007","journal-title":"Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.phrs.2020.105272_bib0260","doi-asserted-by":"crossref","first-page":"H1095","DOI":"10.1152\/ajpheart.00016.2002","article-title":"P38 MAPK: critical molecule in thrombin-induced NF-kappa B-dependent leukocyte recruitment","volume":"284","author":"Kaur","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"8","key":"10.1016\/j.phrs.2020.105272_bib0265","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1128\/JVI.02089-06","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1","volume":"81","author":"Ye","year":"2007","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.phrs.2020.105272_bib0270","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820315802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820315802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:26:24Z","timestamp":1760912784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661820315802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":54,"alternative-id":["S1043661820315802"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105272","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arginine vasopressin receptor 2 activation promotes microvascular permeability in sepsis","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105272","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105272"}}