{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:23:12Z","timestamp":1785399792014,"version":"3.56.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007839","name":"Yunnan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007839","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.phrs.2020.105386","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T11:56:53Z","timestamp":1608379013000},"page":"105386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Novel clerodane-type diterpenoid Cintelactone A suppresses lipopolysaccharide -induced inflammation by promoting ubiquitination, proteasomal degradation of TRAF6"],"prefix":"10.1016","volume":"164","author":[{"given":"Qianqian","family":"Di","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xibao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilie","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7203","key":"10.1016\/j.phrs.2020.105386_bib0005","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2020.105386_bib0010","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/imr.12294","article-title":"Negative regulation of the inflammasome: keeping inflammation under control","volume":"265","author":"Pedraza-Alva","year":"2015","journal-title":"Immunol. Rev."},{"issue":"11\u201312","key":"10.1016\/j.phrs.2020.105386_bib0015","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1007\/s00018-016-2205-2","article-title":"The intersection of cell death and inflammasome activation","volume":"73","author":"Vince","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phrs.2020.105386_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2019.00108","article-title":"Sepsis: inflammation is a necessary evil","volume":"7","author":"Nedeva","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105386_bib0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabetes Res. Clin. Pract. Suppl."},{"issue":"1","key":"10.1016\/j.phrs.2020.105386_bib0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10571-019-00720-5","article-title":"Melatonin and Parkinson disease: current status and future perspectives for molecular mechanisms","volume":"40","author":"Tamtaji","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2020.105386_bib0035","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/978-3-0348-0837-8_16","article-title":"The role of inflammation in liver cancer","volume":"816","author":"Bishayee","year":"2014","journal-title":"Inflamm. Cancer"},{"issue":"16","key":"10.1016\/j.phrs.2020.105386_bib0040","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.2174\/0929867323666160418115540","article-title":"Management of inflammation by natural polyphenols: a comprehensive mechanistic update","volume":"23","author":"Sarkar","year":"2016","journal-title":"Curr. Med. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2020.105386_bib0045","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/all.14032","article-title":"Progress in understanding hypersensitivity reactions to nonsteroidal anti-inflammatory drugs","volume":"75","author":"Dona","year":"2020","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.phrs.2020.105386_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.survophthal.2019.07.001","article-title":"NSAID-induced corneal melt: clinical importance, pathogenesis, and risk mitigation","volume":"65","author":"Rigas","year":"2020","journal-title":"Surv. Ophthalmol."},{"issue":"2","key":"10.1016\/j.phrs.2020.105386_bib0055","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3390\/metabo2020303","article-title":"A historical overview of natural products in drug discovery","volume":"2","author":"Dias","year":"2012","journal-title":"Metabolites"},{"issue":"19\u201320","key":"10.1016\/j.phrs.2020.105386_bib0060","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.drudis.2008.07.004","article-title":"Natural products in drug discovery","volume":"13","author":"Harvey","year":"2008","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.phrs.2020.105386_bib0065","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.phrs.2020.105386_bib0070","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat. Immunol."},{"issue":"38","key":"10.1016\/j.phrs.2020.105386_bib0075","doi-asserted-by":"crossref","first-page":"15247","DOI":"10.1073\/pnas.1314715110","article-title":"Activation of the canonical IKK complex by K63\/M1-linked hybrid ubiquitin chains","volume":"110","author":"Emmerich","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7260","key":"10.1016\/j.phrs.2020.105386_bib0080","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature08247","article-title":"Direct activation of protein kinases by unanchored polyubiquitin chains","volume":"461","author":"Xia","year":"2009","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.phrs.2020.105386_bib0085","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1080\/15548627.2018.1474995","article-title":"Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation","volume":"14","author":"Min","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2020.105386_bib0090","doi-asserted-by":"crossref","first-page":"14715","DOI":"10.1038\/srep14715","article-title":"Natural small molecule FMHM inhibits lipopolysaccharide-induced inflammatory response by promoting TRAF6 degradation via K48-linked polyubiquitination","volume":"5","author":"Zeng","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.phrs.2020.105386_bib0095","first-page":"77","article-title":"Triterpenes from Callicarpa integerrima champ","volume":"47","author":"Zhu","year":"2012","journal-title":"Yao Xue Xue Bao"},{"issue":"11","key":"10.1016\/j.phrs.2020.105386_bib0100","first-page":"19","article-title":"Citation classic - electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets - procedure and some applications","author":"Towbin","year":"1988","journal-title":"Cc\/Life Sci."},{"key":"10.1016\/j.phrs.2020.105386_bib0105","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00565","article-title":"Teuvincenone F suppresses LPS-Induced inflammation and NLRP3 inflammasome activation by attenuating NEMO ubiquitination","volume":"8","author":"Zhao","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105386_bib0110","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.phrs.2020.105386_bib0115","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1006\/jmbi.1996.0477","article-title":"A fast flexible docking method using an incremental construction algorithm","volume":"261","author":"Rarey","year":"1996","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.phrs.2020.105386_bib0120","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nsmb.1605","article-title":"E2 interaction and dimerization in the crystal structure of TRAF6","volume":"16","author":"Yin","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.phrs.2020.105386_bib0125","first-page":"13","article-title":"Bcl::cluster\u202f: a method for clustering biological molecules coupled with visualization in the pymol molecular graphics system, IEEE \u2026 International Conference on computational advances in bio and medical sciences\u202f: [proceedings]","author":"Alexander","year":"2011","journal-title":"IEEE International Conference on Computational Advances in Bio and Medical Sciences 2011"},{"issue":"2","key":"10.1016\/j.phrs.2020.105386_bib0130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/protein\/8.2.127","article-title":"LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions","volume":"8","author":"Wallace","year":"1995","journal-title":"Protein Eng."},{"issue":"6","key":"10.1016\/j.phrs.2020.105386_bib0135","doi-asserted-by":"crossref","first-page":"441","DOI":"10.14348\/molcells.2014.0104","article-title":"Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases","volume":"37","author":"Choi","year":"2014","journal-title":"Mol. Cells"},{"issue":"11","key":"10.1016\/j.phrs.2020.105386_bib0140","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.4161\/21645515.2014.979640","article-title":"Mechanisms and pathways of innate immune activation and regulation in health and cancer","volume":"10","author":"Cui","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"issue":"11","key":"10.1016\/j.phrs.2020.105386_bib0145","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.phrs.2020.105386_bib0150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nri3111","article-title":"The role of ubiquitylation in immune defence and pathogen evasion","volume":"12","author":"Jiang","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.phrs.2020.105386_bib0155","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.phrs.2020.105386_bib0160","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-017-0639-8","article-title":"Cytokine storm and sepsis disease pathogenesis","volume":"39","author":"Chousterman","year":"2017","journal-title":"Semin. Immunopathol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105386_bib0165","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23040935","article-title":"Structural diversity and biological activities of diterpenoids derived from Euphorbia fischeriana steud","volume":"23","author":"Jian","year":"2018","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.phrs.2020.105386_bib0170","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1039\/C8NP00016F","article-title":"Halimane diterpenoids: sources, structures, nomenclature and biological activities","volume":"35","author":"Roncero","year":"2018","journal-title":"Nat. Prod. Rep."},{"issue":"6","key":"10.1016\/j.phrs.2020.105386_bib0175","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1039\/b705951p","article-title":"Diterpenoids","volume":"24","author":"Hanson","year":"2007","journal-title":"Nat. Prod. Rep."},{"issue":"5","key":"10.1016\/j.phrs.2020.105386_bib0180","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1476-5381.2009.00609.x","article-title":"16alpha-Hydroxycleroda-3,13 (14)Z-dien-15,16-olide from Polyalthia longifolia: a safe and orally active antileishmanial agent","volume":"159","author":"Misra","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2020.105386_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2015.02.054","article-title":"Clerodane type diterpene as a novel antifungal agent from Polyalthia longifolia var. pendula","volume":"94","author":"Bhattacharya","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.phrs.2020.105386_bib0190","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/ni0605-544","article-title":"A smooth operator for LPS responses","volume":"6","author":"Godowski","year":"2005","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.phrs.2020.105386_bib0195","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.apsb.2015.01.010","article-title":"Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-kappa B and iNOS signaling pathways","volume":"5","author":"Wu","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2020.105386_bib0200","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.3389\/fmicb.2019.03040","article-title":"BICP0 negatively regulates TRAF6-Mediated NF-kappaB and interferon activation by promoting K48-Linked polyubiquitination of TRAF6","volume":"10","author":"Cao","year":"2019","journal-title":"Front. Microbiol."},{"issue":"6","key":"10.1016\/j.phrs.2020.105386_bib0205","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.4049\/jimmunol.1103255","article-title":"E3 ubiquitin ligase tripartite motif 38 negatively regulates TLR-mediated immune responses by proteasomal degradation of TNF receptor-associated factor 6 in macrophages","volume":"188","author":"Zhao","year":"2012","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.phrs.2020.105386_bib0210","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bbrc.2010.01.037","article-title":"NUMBL interacts with TRAF6 and promotes the degradation of TRAF6","volume":"392","author":"Zhou","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2020.105386_bib0215","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s11658-019-0156-y","article-title":"C-Cbl negatively regulates TRAF6-mediated NF-kappaB activation by promoting K48-linked polyubiquitination of TRAF6","volume":"24","author":"Jang","year":"2019","journal-title":"Cell. Mol. Biol. Lett."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820316947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661820316947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:21:46Z","timestamp":1760912506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661820316947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":43,"alternative-id":["S1043661820316947"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105386","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel clerodane-type diterpenoid Cintelactone A suppresses lipopolysaccharide -induced inflammation by promoting ubiquitination, proteasomal degradation of TRAF6","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2020.105386","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105386"}}