{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:08:47Z","timestamp":1777468127390,"version":"3.51.4"},"reference-count":144,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008257","name":"Tarbiat Modares University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.phrs.2021.105441","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T10:01:53Z","timestamp":1611482513000},"page":"105441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Targeting the brain lesions using peptides: A review focused on the possibility of targeted drug delivery to multiple sclerosis lesions"],"prefix":"10.1016","volume":"167","author":[{"given":"Atefeh","family":"Rayatpour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-6171","authenticated-orcid":false,"given":"Mohammad","family":"Javan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0005","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.phrs.2021.105441_bib0010","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S1474-4422(12)70230-2","article-title":"Measurement and clinical effect of grey matter pathology in multiple sclerosis","volume":"11","author":"Geurts","year":"2012","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0015","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00401-019-02120-x","article-title":"Antibody signatures in patients with histopathologically defined multiple sclerosis patterns","volume":"139","author":"Stork","year":"2020","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0020","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00401-012-0953-0","article-title":"Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity?","volume":"123","author":"Antel","year":"2012","journal-title":"Acta Neuropathol."},{"issue":"10076","key":"10.1016\/j.phrs.2021.105441_bib0025","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0140-6736(16)31320-4","article-title":"Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function","volume":"389","author":"Ontaneda","year":"2017","journal-title":"Lancet (London, England)"},{"issue":"12","key":"10.1016\/j.phrs.2021.105441_bib0030","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nrn.2017.136","article-title":"Regenerating CNS myelin \u2013 from mechanisms to experimental medicines","volume":"18","author":"Franklin","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nrn3898","article-title":"Astrocyte barriers to neurotoxic inflammation","volume":"16","author":"Sofroniew","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0040","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020420","article-title":"Astrogliosis","volume":"7","author":"Sofroniew","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0045","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrn2591","article-title":"The bright side of the glial scar in CNS repair","volume":"10","author":"Rolls","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0050","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1750-3639.2010.00399.x","article-title":"Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells","volume":"20","author":"Mohan","year":"2010","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"key":"10.1016\/j.phrs.2021.105441_bib0055","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.3389\/fimmu.2017.01810","article-title":"Gene expression profiling of multiple sclerosis pathology identifies early patterns of demyelination surrounding chronic active lesions","volume":"8","author":"Hendrickx","year":"2017","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0060","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00401-016-1631-4","article-title":"Multiple sclerosis: experimental models and reality","volume":"133","author":"Lassmann","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.phrs.2021.105441_bib0065","series-title":"Oligodendrocytes","first-page":"377","article-title":"Toxin-based models to investigate demyelination and remyelination","author":"McMurran","year":"2019"},{"key":"10.1016\/j.phrs.2021.105441_bib0070","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pneurobio.2012.11.003","article-title":"Viral models of multiple sclerosis: neurodegeneration and demyelination in mice infected with Theiler\u2019s virus","volume":"101","author":"Mecha","year":"2013","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0075","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/ana.20913","article-title":"How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis","volume":"60","author":"Steinman","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phrs.2021.105441_bib0080","unstructured":"Available from: https:\/\/www.nationalmssociety.org\/Treating-MS\/Medications."},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0085","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.neuron.2018.01.021","article-title":"Multiple sclerosis: mechanisms and immunotherapy","volume":"97","author":"Baecher-Allan","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2021.105441_bib0090","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.msard.2018.01.012","article-title":"Pulse steroid therapy in multiple sclerosis and mood changes: an exploratory prospective study","volume":"20","author":"Lorefice","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"28","key":"10.1016\/j.phrs.2021.105441_bib0095","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1002\/adma.201200454","article-title":"Peptides as targeting elements and tissue penetration devices for nanoparticles","volume":"24","author":"Ruoslahti","year":"2012","journal-title":"Adv. Mater. (Deerfield Beach, Fla)"},{"key":"10.1016\/j.phrs.2021.105441_bib0100","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ijbiomac.2019.12.258","article-title":"Enhancing myelin repair in experimental model of multiple sclerosis using immobilized chondroitinase ABC I on porous silicon nanoparticles","volume":"146","author":"Rezaei","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0105","first-page":"310","article-title":"Protective effects of a nano-formulation of curcumin against cuprizone-induced demyelination in the mouse corpus callosum","volume":"19","author":"Motavaf","year":"2020","journal-title":"Iran. J. Pharm. Res."},{"issue":"10","key":"10.1016\/j.phrs.2021.105441_bib0110","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/term.3110","article-title":"Dendrosomal nanocurcumin promotes remyelination through induction of oligodendrogenesis in experimental demyelination animal model","volume":"14","author":"Motavaf","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0115","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jconrel.2012.06.022","article-title":"Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation","volume":"164","author":"Gaillard","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phrs.2021.105441_bib0120","series-title":"Active Targeting. Fundamentals of Pharmaceutical Nanoscience","first-page":"337","author":"Lopez","year":"2013"},{"key":"10.1016\/j.phrs.2021.105441_bib0125","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2017.02.006","article-title":"Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides","volume":"250","author":"Dissanayake","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phrs.2021.105441_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2018.01.029","article-title":"Chemotherapeutic drug delivery by tumoral extracellular matrix targeting","volume":"274","author":"Raav\u00e9","year":"2018","journal-title":"J. Control. Release"},{"issue":"21","key":"10.1016\/j.phrs.2021.105441_bib0135","doi-asserted-by":"crossref","first-page":"10488","DOI":"10.1073\/pnas.1816911116","article-title":"Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis","volume":"116","author":"Willis","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phrs.2021.105441_bib0140","series-title":"Advances in Multiple Sclerosis and Experimental Demyelinating Diseases","first-page":"193","article-title":"Remyelination in experimental models of toxin-induced demyelination","author":"Blakemore","year":"2008"},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/bpa.12454","article-title":"Multiple sclerosis animal models: a clinical and histopathological perspective","volume":"27","author":"Kipp","year":"2017","journal-title":"Brain Pathol."},{"issue":"6","key":"10.1016\/j.phrs.2021.105441_bib0150","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/jnr.24224","article-title":"Animal models of multiple sclerosis: focus on experimental autoimmune encephalomyelitis","volume":"96","author":"Bjelobaba","year":"2018","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0155","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbadis.2010.06.010","article-title":"Mouse models for multiple sclerosis: historical facts and future implications","volume":"1812","author":"Croxford","year":"2011","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol. BasisDisease"},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0160","doi-asserted-by":"crossref","first-page":"e5585","DOI":"10.1371\/journal.pone.0005585","article-title":"Non-invasive molecular imaging of fibrosis using a collagen-targeted peptidomimetic of the platelet collagen receptor glycoprotein VI","volume":"4","author":"Muzard","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0165","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4103\/1673-5374.230273","article-title":"Collagen for brain repair: therapeutic perspectives","volume":"13","author":"Ucar","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phrs.2021.105441_bib0170","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.biomaterials.2014.10.062","article-title":"Astrocytes alignment and reactivity on collagen hydrogels patterned with ECM proteins","volume":"39","author":"Hsiao","year":"2015","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.phrs.2021.105441_bib0175","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrn3550","article-title":"Pathophysiology of the brain extracellular matrix: a new target for remyelination","volume":"14","author":"Lau","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.phrs.2021.105441_bib0180","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nm.4354","article-title":"Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury","volume":"23","author":"Hara","year":"2017","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0185","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12026-018-9011-x","article-title":"RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis","volume":"66","author":"Tatomir","year":"2018","journal-title":"Immunol. Res."},{"issue":"6","key":"10.1016\/j.phrs.2021.105441_bib0190","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/ana.25461","article-title":"The \u201cCentral Vein Sign\u201d in inflammatory demyelination: the role of fibrillar collagen type I","volume":"85","author":"Absinta","year":"2019","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0195","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmat2116","article-title":"Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage","volume":"7","author":"Rothenfluh","year":"2008","journal-title":"Nat. Mater."},{"issue":"12","key":"10.1016\/j.phrs.2021.105441_bib0200","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrm3902","article-title":"Extracellular matrix assembly: a multiscale deconstruction","volume":"15","author":"Mouw","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"36","key":"10.1016\/j.phrs.2021.105441_bib0205","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1021\/bi00151a021","article-title":"A collagen\/gelatin-binding decapeptide derived from bovine propolypeptide of von Willebrand factor","volume":"31","author":"Takagi","year":"1992","journal-title":"Biochemistry"},{"issue":"7","key":"10.1016\/j.phrs.2021.105441_bib0210","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1158\/1541-7786.MCR-08-0538","article-title":"Targeting of tumor blood vessels: a phage-displayed tumor-homing peptide specifically binds to matrix metalloproteinase-2-processed collagen IV and blocks angiogenesis in vivo","volume":"7","author":"Mueller","year":"2009","journal-title":"Mol. Cancer Res."},{"issue":"8","key":"10.1016\/j.phrs.2021.105441_bib0215","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/01.jnen.0000173894.09553.13","article-title":"Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes","volume":"64","author":"van Horssen","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124510","article-title":"Plasminogen activator inhibitor-1 antagonist TM5484 attenuates demyelination and axonal degeneration in a mice model of multiple sclerosis","volume":"10","author":"Pelisch","year":"2015","journal-title":"PLoS One"},{"issue":"Pt 1","key":"10.1016\/j.phrs.2021.105441_bib0225","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/brain\/aws313","article-title":"Fibronectin aggregation in multiple sclerosis lesions impairs remyelination","volume":"136","author":"Stoffels","year":"2013","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0230","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1021\/acs.bioconjchem.5b00178","article-title":"EDB fibronectin specific peptide for prostate cancer targeting","volume":"26","author":"Han","year":"2015","journal-title":"Bioconjug. Chem."},{"issue":"8","key":"10.1016\/j.phrs.2021.105441_bib0235","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/anie.201107894","article-title":"Bio-inspired design and potential biomedical applications of a novel class of high-affinity peptides","volume":"51","author":"Kim","year":"2012","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"8","key":"10.1016\/j.phrs.2021.105441_bib0240","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1073\/pnas.0511219103","article-title":"Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds","volume":"103","author":"Pilch","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0245","first-page":"161","article-title":"Fibronectin in multiple sclerosis lesions","volume":"135","author":"Sobel","year":"1989","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0250","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/BF00296505","article-title":"Evidence of persistent blood-brain barrier abnormalities in chronic-progressive multiple sclerosis","volume":"90","author":"Claudio","year":"1995","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0255","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1016\/j.neuron.2017.10.008","article-title":"Fibrinogen activates BMP signaling in oligodendrocyte progenitor cells and inhibits remyelination after vascular damage","volume":"96","author":"Petersen","year":"2017","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0260","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/ana.24242","article-title":"The formation of inflammatory demyelinated lesions in cerebral white matter","volume":"76","author":"Maggi","year":"2014","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0265","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.nbd.2005.06.012","article-title":"Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis","volume":"20","author":"Vos","year":"2005","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0270","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1073\/pnas.0610298104","article-title":"Biomimetic amplification of nanoparticle homing to tumors","volume":"104","author":"Simberg","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2021.105441_bib0275","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neulet.2015.06.049","article-title":"Peptide-functionalized polymeric nanoparticles for active targeting of damaged tissue in animals with experimental autoimmune encephalomyelitis","volume":"602","author":"Fuhrmann","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2021.105441_bib0280","doi-asserted-by":"crossref","first-page":"11980","DOI":"10.1038\/ncomms11980","article-title":"A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries","volume":"7","author":"Mann","year":"2016","journal-title":"Nat. Commun."},{"issue":"16","key":"10.1016\/j.phrs.2021.105441_bib0285","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.7150\/thno.26717","article-title":"Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair","volume":"8","author":"Wang","year":"2018","journal-title":"Theranostics"},{"issue":"12","key":"10.1016\/j.phrs.2021.105441_bib0290","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/jnen\/60.12.1198","article-title":"White matter extracellular matrix chondroitin sulfate\/dermatan sulfate proteoglycans in multiple sclerosis","volume":"60","author":"Sobel","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.phrs.2021.105441_bib0295","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1038\/ncomms11312","article-title":"An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination","volume":"7","author":"Keough","year":"2016","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0300","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1535-6108(03)00273-3","article-title":"Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma","volume":"4","author":"Hoffman","year":"2003","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0305","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1750-3639.2008.00152.x","article-title":"Heparan sulfate accumulation with A\u03b2 deposits in Alzheimer\u2019s disease and Tg2576 mice is contributed by glial cells","volume":"18","author":"O\u2019Callaghan","year":"2008","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0310","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1750-3639.2005.tb00098.x","article-title":"Ephrin A receptors and ligands in lesions and normal\u2010appearing white matter in multiple sclerosis","volume":"15","author":"Sobel","year":"2005","journal-title":"Brain Pathol."},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0315","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.mcn.2003.08.006","article-title":"Targeting the EphA4 receptor in the nervous system with biologically active peptides","volume":"24","author":"Murai","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"issue":"11","key":"10.1016\/j.phrs.2021.105441_bib0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080183","article-title":"Discovery and characterization of a novel cyclic peptide that effectively inhibits ephrin binding to the EphA4 receptor and displays anti-angiogenesis activity","volume":"8","author":"Han","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0325","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1046\/j.1365-2990.2003.00491.x","article-title":"Astrocyte characterization in the multiple sclerosis glial scar","volume":"29","author":"Holley","year":"2003","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0330","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1365-2990.1999.00176.x","article-title":"Tenascin-R and C in multiple sclerosis lesions: relevance to extracellular matrix remodelling","volume":"25","author":"Gutowski","year":"1999","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0335","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/S10059-012-2214-4","article-title":"Selection and characterization of tenascin C targeting peptide","volume":"33","author":"Kim","year":"2012","journal-title":"Mol. Cells"},{"issue":"15","key":"10.1016\/j.phrs.2021.105441_bib0340","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1002\/jnr.22231","article-title":"Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination","volume":"87","author":"Zhao","year":"2009","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-62760-y","article-title":"Tumor-penetrating peptide for systemic targeting of tenascin-c","volume":"10","author":"Lingasamy","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0350","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1007\/s10753-018-0748-0","article-title":"A peptide targeting inflammatory CNS lesions in the EAE rat model of multiple sclerosis","volume":"41","author":"Boiziau","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.phrs.2021.105441_bib0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcp.2020.101530","article-title":"A novel CNS-homing peptide for targeting neuroinflammatory lesions in experimental autoimmune encephalomyelitis","author":"Acharya","year":"2020","journal-title":"Mol. Cell. Probes"},{"issue":"Pt 20","key":"10.1016\/j.phrs.2021.105441_bib0360","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1242\/jcs.00059","article-title":"Fibronectin at a glance","volume":"115","author":"Pankov","year":"2002","journal-title":"J. Cell. Sci."},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0365","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/glia.22748","article-title":"The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination","volume":"63","author":"Stoffels","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.phrs.2021.105441_bib0370","doi-asserted-by":"crossref","first-page":"40995","DOI":"10.1038\/srep40995","article-title":"Astrocyte-derived tissue Transglutaminase affects fibronectin deposition, but not aggregation, during cuprizone-induced demyelination","volume":"7","author":"Espitia Pinzon","year":"2017","journal-title":"Sci. Rep."},{"issue":"37","key":"10.1016\/j.phrs.2021.105441_bib0375","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1039\/c3tb20815j","article-title":"Aptide-conjugated liposome targeting tumor-associated fibronectin for glioma therapy","volume":"1","author":"Saw","year":"2013","journal-title":"J. Mater. Chem. B"},{"issue":"7","key":"10.1016\/j.phrs.2021.105441_bib0380","doi-asserted-by":"crossref","first-page":"746","DOI":"10.7150\/thno.10732","article-title":"Effect of PEG pairing on the efficiency of cancer-targeting liposomes","volume":"5","author":"Saw","year":"2015","journal-title":"Theranostics"},{"issue":"28","key":"10.1016\/j.phrs.2021.105441_bib0385","doi-asserted-by":"crossref","first-page":"8215","DOI":"10.1016\/j.biomaterials.2014.06.022","article-title":"PEG-PLA nanoparticles modified with APTEDB peptide for enhanced anti-angiogenic and anti-glioma therapy","volume":"35","author":"Gu","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.phrs.2021.105441_bib0390","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jconrel.2014.01.015","article-title":"Synthesis and therapeutic evaluation of an aptide-docetaxel conjugate targeting tumor-associated fibronectin","volume":"178","author":"Kim","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phrs.2021.105441_bib0395","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.nbd.2018.11.018","article-title":"Inactivation of sphingosine-1-phosphate receptor 2 (S1PR2) decreases demyelination and enhances remyelination in animal models of multiple sclerosis","volume":"124","author":"Seyedsadr","year":"2019","journal-title":"Neurobiol. Dis."},{"issue":"17","key":"10.1016\/j.phrs.2021.105441_bib0400","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1073\/pnas.0303859101","article-title":"Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis","volume":"101","author":"Akassoglou","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0405","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1084\/jem.20061931","article-title":"The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease","volume":"204","author":"Adams","year":"2007","journal-title":"J. Exp. Med."},{"issue":"13","key":"10.1016\/j.phrs.2021.105441_bib0410","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1016\/j.biomaterials.2014.01.046","article-title":"Targeting fibronectins of glioma extracellular matrix by CLT1 peptide-conjugated nanoparticles","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.phrs.2021.105441_bib0415","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jcis.2015.03.019","article-title":"CREKA peptide-conjugated dendrimer nanoparticles for glioblastoma multiforme delivery","volume":"450","author":"Zhao","year":"2015","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.phrs.2021.105441_bib0420","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1038\/ncomms8984","article-title":"MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent","volume":"6","author":"Zhou","year":"2015","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0425","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","article-title":"Regeneration beyond the glial scar","volume":"5","author":"Silver","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phrs.2021.105441_bib0430","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.matbio.2018.04.010","article-title":"Pro-inflammatory roles of chondroitin sulfate proteoglycans in disorders of the central nervous system","volume":"71-72","author":"Stephenson","year":"2018","journal-title":"Matrix Biol."},{"issue":"68\u201369","key":"10.1016\/j.phrs.2021.105441_bib0435","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.matbio.2018.01.015","article-title":"Role of proteoglycans in neuro-inflammation and central nervous system fibrosis","author":"Heindryckx","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.phrs.2021.105441_bib0440","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.2147\/IJN.S202353","article-title":"Targeted delivery of polypeptide nanoparticle for treatment of traumatic brain injury","volume":"14","author":"Wu","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0445","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40820-019-0252-6","article-title":"Synthesis and characterization of a silica-based drug delivery system for spinal cord injury therapy","volume":"11","author":"Sun","year":"2019","journal-title":"Nano-Micro Lett."},{"issue":"42","key":"10.1016\/j.phrs.2021.105441_bib0450","doi-asserted-by":"crossref","first-page":"17450","DOI":"10.1073\/pnas.1114518108","article-title":"Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma","volume":"108","author":"Agemy","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0455","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrd4175","article-title":"Therapeutic targeting of EPH receptors and their ligands","volume":"13","author":"Boyd","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"issue":"30","key":"10.1016\/j.phrs.2021.105441_bib0460","doi-asserted-by":"crossref","first-page":"10694","DOI":"10.1073\/pnas.0504021102","article-title":"Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth","volume":"102","author":"Benson","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0465","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00401-015-1521-1","article-title":"Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination","volume":"131","author":"Syed","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0470","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/BJ20120408","article-title":"Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor","volume":"445","author":"Lamberto","year":"2012","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.phrs.2021.105441_bib0475","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1111\/j.1460-9568.2007.05859.x","article-title":"Regeneration\u2010enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord","volume":"26","author":"Fabes","year":"2007","journal-title":"Eur. J. Neurosci."},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0480","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.molimm.2007.09.019","article-title":"EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions","volume":"45","author":"Sharfe","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phrs.2021.105441_bib0485","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/321209","article-title":"Astrocyte-secreted matricellular proteins in CNS remodelling during development and disease","volume":"2014","author":"Jones","year":"2014","journal-title":"Neural Plast."},{"issue":"7","key":"10.1016\/j.phrs.2021.105441_bib0490","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1073\/pnas.89.7.2634","article-title":"Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury","volume":"89","author":"Laywell","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"24","key":"10.1016\/j.phrs.2021.105441_bib0495","doi-asserted-by":"crossref","first-page":"9624","DOI":"10.1523\/JNEUROSCI.17-24-09624.1997","article-title":"Macrophage\/microglia regulation of astrocytic tenascin: synergistic action of transforming growth factor-\u03b2 and basic fibroblast growth factor","volume":"17","author":"Smith","year":"1997","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0500","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.canlet.2006.02.017","article-title":"Tenascin-C induced signaling in cancer","volume":"244","author":"Orend","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2021.105441_bib0505","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.biomaterials.2016.05.037","article-title":"Synergistic targeting tenascin C and neuropilin-1 for specific penetration of nanoparticles for anti-glioblastoma treatment","volume":"101","author":"Kang","year":"2016","journal-title":"Biomaterials"},{"issue":"7770","key":"10.1016\/j.phrs.2021.105441_bib0510","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41586-019-1467-x","article-title":"Opposing T cell responses in experimental autoimmune encephalomyelitis","volume":"572","author":"Saligrama","year":"2019","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.phrs.2021.105441_bib0515","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00011-011-0331-8","article-title":"Mimic peptides bonding specifically with the first and second extracellular loops of the CC chemokine receptor 5 derived from a phage display peptide library are potent inhibitors of experimental autoimmune encephalomyelitis","volume":"60","author":"Zheng","year":"2011","journal-title":"Inflamm. Res."},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0520","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri.2017.125","article-title":"Microglia and macrophages in brain homeostasis and disease","volume":"18","author":"Li","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.phrs.2021.105441_bib0525","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nn.4338","article-title":"A polarizing question: do M1 and M2 microglia exist?","volume":"19","author":"Ransohoff","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0530","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.phrs.2021.105441_bib0535","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/brain\/awx113","article-title":"Loss of\u2019 homeostatic\u2019 microglia and patterns of their activation in active multiple sclerosis","volume":"140","author":"Zrzavy","year":"2017","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0540","doi-asserted-by":"crossref","first-page":"14655","DOI":"10.1038\/s41598-017-14709-x","article-title":"Precision targeting of tumor macrophages with a CD206 binding peptide","volume":"7","author":"Scodeller","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2021.105441_bib0545","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.omtn.2018.02.007","article-title":"Gene therapy for neuropathic pain through siRNA-IRF5 gene delivery with homing peptides to microglia","volume":"11","author":"Terashima","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0550","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41467-017-01096-0","article-title":"Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer\u2019s disease","volume":"8","author":"Mann","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0555","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/bc500408p","article-title":"Dual peptide conjugation strategy for improved cellular uptake and mitochondria targeting","volume":"26","author":"Lin","year":"2015","journal-title":"Bioconjug. Chem."},{"issue":"33","key":"10.1016\/j.phrs.2021.105441_bib0560","doi-asserted-by":"crossref","first-page":"34682","DOI":"10.1074\/jbc.M402999200","article-title":"Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury","volume":"279","author":"Zhao","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0565","doi-asserted-by":"crossref","first-page":"E277","DOI":"10.1007\/BF02854898","article-title":"Cell-permeable, mitochondrial-targeted, peptide antioxidants","volume":"8","author":"Szeto","year":"2006","journal-title":"AAPS J."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0570","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1007\/s11064-016-2088-5","article-title":"Role of matricellular proteins in disorders of the central nervous system","volume":"42","author":"Jayakumar","year":"2017","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0575","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(02)00670-X","article-title":"Connective tissue growth factor in Alzheimer\u2019s disease","volume":"116","author":"Ueberham","year":"2003","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0580","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00401-003-0741-y","article-title":"Increased expression of connective tissue growth factor in amyotrophic lateral sclerosis human spinal cord","volume":"106","author":"Spliet","year":"2003","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0585","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3171\/spi.2005.2.3.0319","article-title":"Spinal cord injury induction of lesional expression of profibrotic and angiogenic connective tissue growth factor confined to reactive astrocytes, invading fibroblasts and endothelial cells","volume":"2","author":"Conrad","year":"2005","journal-title":"J. Neurosurg. Spine"},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0590","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/089771501750170930","article-title":"Differential cellular accumulation of connective tissue growth factor defines a subset of reactive astrocytes, invading fibroblasts, and endothelial cells following central nervous system injury in rats and humans","volume":"18","author":"Schwab","year":"2001","journal-title":"J. Neurotrauma"},{"issue":"5","key":"10.1016\/j.phrs.2021.105441_bib0595","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1046\/j.1365-2990.2000.00271.x","article-title":"Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarction","volume":"26","author":"Schwab","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"Pt 5","key":"10.1016\/j.phrs.2021.105441_bib0600","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/brain\/awp046","article-title":"Mitochondrial changes within axons in multiple sclerosis","volume":"132","author":"Mahad","year":"2009","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0605","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/17425247.2016.1218461","article-title":"Mitochondria and neurodegenerative diseases: the promising role of nanotechnology in targeted drug delivery","volume":"14","author":"Pezzini","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"issue":"16","key":"10.1016\/j.phrs.2021.105441_bib0610","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1007\/s00018-005-5178-0","article-title":"Bacterial signal peptide recognizes HeLa cell mitochondrial import receptors and functions as a mitochondrial leader sequence","volume":"62","author":"Mukhopadhyay","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"12","key":"10.1016\/j.phrs.2021.105441_bib0615","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.bcp.2005.08.022","article-title":"Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines","volume":"70","author":"Zhao","year":"2005","journal-title":"Biochem. Pharmacol."},{"issue":"s2","key":"10.1016\/j.phrs.2021.105441_bib0620","doi-asserted-by":"crossref","first-page":"S609","DOI":"10.3233\/JAD-2010-100564","article-title":"Mitochondria-targeted antioxidants protect against amyloid-\u03b2 toxicity in Alzheimer\u2019s disease neurons","volume":"20","author":"Manczak","year":"2010","journal-title":"J. Alzheimer Dis."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0625","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbrc.2016.07.071","article-title":"Mitochondria-targeted antioxidant mitotempo protects mitochondrial function against amyloid beta toxicity in primary cultured mouse neurons","volume":"478","author":"Hu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.phrs.2021.105441_bib0630","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1074\/jbc.M609388200","article-title":"A novel cell-permeable antioxidant peptide, SS31, attenuates ischemic brain injury by down-regulating CD36","volume":"282","author":"Cho","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2021.105441_bib0635","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep33249","article-title":"Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis","volume":"6","author":"Sadeghian","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0640","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/17425247.2016.1213237","article-title":"Cell-penetrating peptides with intracellular organelle targeting","volume":"14","author":"Cerrato","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"issue":"3","key":"10.1016\/j.phrs.2021.105441_bib0645","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/BJ20041095","article-title":"Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers","volume":"383","author":"Ross","year":"2004","journal-title":"Biochem. J."},{"issue":"17","key":"10.1016\/j.phrs.2021.105441_bib0650","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1039\/C6CS00076B","article-title":"Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery","volume":"45","author":"Oller-Salvia","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.phrs.2021.105441_bib0655","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2016.05.044","article-title":"Nanoparticle-mediated brain drug delivery: overcoming blood\u2013brain barrier to treat neurodegenerative diseases","volume":"235","author":"Saraiva","year":"2016","journal-title":"J. Control. Release"},{"issue":"22","key":"10.1016\/j.phrs.2021.105441_bib0660","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4155\/fmc-2018-0208","article-title":"Nanodelivery systems for overcoming limited transportation of therapeutic molecules through the blood\u2013brain barrier","volume":"10","author":"Kim","year":"2018","journal-title":"Future Med. Chem."},{"issue":"5433","key":"10.1016\/j.phrs.2021.105441_bib0665","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1126\/science.285.5433.1569","article-title":"In vivo protein transduction: delivery of a biologically active protein into the mouse","volume":"285","author":"Schwarze","year":"1999","journal-title":"Science"},{"issue":"5594","key":"10.1016\/j.phrs.2021.105441_bib0670","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1126\/science.1072873","article-title":"Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions","volume":"298","author":"Aarts","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.phrs.2021.105441_bib0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2019.103391","article-title":"Modulating proteoglycan receptor PTP\u03c3 using intracellular sigma peptide improves remyelination and functional recovery in mice with demyelinated optic chiasm","volume":"99","author":"Niknam","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2021.105441_bib0680","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1007\/s11095-012-0667-y","article-title":"Targeted delivery of proteins into the central nervous system mediated by rabies virus glycoprotein-derived peptide","volume":"29","author":"Fu","year":"2012","journal-title":"Pharm. Res."},{"issue":"8","key":"10.1016\/j.phrs.2021.105441_bib0685","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3109\/1061186X.2010.523788","article-title":"Targeted delivery of large fusion protein into hippocampal neurons by systemic administration","volume":"19","author":"Xiang","year":"2011","journal-title":"J. Drug Target."},{"key":"10.1016\/j.phrs.2021.105441_bib0690","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biomaterials.2015.11.060","article-title":"Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer\u2019s disease mice","volume":"80","author":"Liu","year":"2016","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.phrs.2021.105441_bib0695","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1242\/dev.01103","article-title":"Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone","volume":"131","author":"Caill\u00e9","year":"2004","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.phrs.2021.105441_bib0700","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0962-8924(98)80017-2","article-title":"Trojan peptides: the penetratin system for intracellular delivery","volume":"8","author":"Derossi","year":"1998","journal-title":"Trends Cell Biol."},{"issue":"7","key":"10.1016\/j.phrs.2021.105441_bib0705","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235979","article-title":"Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins","volume":"15","author":"Tanaka","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.phrs.2021.105441_bib0710","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0026-895X(24)26466-X","article-title":"New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy","volume":"57","author":"Rousselle","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105441_bib0715","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.neuroscience.2011.09.025","article-title":"The design and delivery of a thermally responsive peptide to inhibit S100B-mediated neurodegeneration","volume":"197","author":"Hearst","year":"2011","journal-title":"Neuroscience"},{"issue":"43","key":"10.1016\/j.phrs.2021.105441_bib0720","article-title":"Bioinspired peptoid nanotubes for targeted tumor cell imaging and chemo\u2010photodynamic therapy","volume":"15","author":"Luo","year":"2019","journal-title":"Small"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821000244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821000244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:27:41Z","timestamp":1760912861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661821000244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":144,"alternative-id":["S1043661821000244"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105441","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the brain lesions using peptides: A review focused on the possibility of targeted drug delivery to multiple sclerosis lesions","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105441","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105441"}}