{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:56:13Z","timestamp":1793361373836,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.phrs.2021.105515","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T23:30:29Z","timestamp":1614123029000},"page":"105515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Association between renin-angiotensin-aldosterone system inhibitors and risk of dementia: A meta-analysis"],"prefix":"10.1016","volume":"166","author":[{"given":"Lorenza","family":"Scotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Soranna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3977-6995","authenticated-orcid":false,"given":"Federico","family":"Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Silani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Torsello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Parati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Zambon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2021.105515_bib1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1001\/jama.2019.4782","article-title":"Diagnosis and management of dementia: review","volume":"322","author":"Arvanitakis","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2021.105515_bib2","unstructured":"http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia."},{"key":"10.1016\/j.phrs.2021.105515_bib3","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0140-6736(96)90608-X","article-title":"15-year longitudinal study of blood pressure and dementia","volume":"347","author":"Skoog","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2021.105515_bib4","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1001\/jama.2020.4249","article-title":"Association of blood pressure lowering with incident dementia or cognitive impairment: a systematic review and meta-analysis","volume":"323","author":"Hughes","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2021.105515_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2021.105515_bib6","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1212\/WNL.0000000000008732","article-title":"Investigation of antihypertensive class, dementia, and cognitive decline: a meta-analysis","volume":"94","author":"Peters","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2021.105515_bib7","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cmet.2008.03.010","article-title":"Hypertension and cerebrovascular dysfunction","volume":"7","author":"Iadecola","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2021.105515_bib8","doi-asserted-by":"crossref","first-page":"H435","DOI":"10.1152\/ajpheart.00262.2004","article-title":"From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension","volume":"287","author":"Schiffrin","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phrs.2021.105515_bib9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00441-006-0190-8","article-title":"The CNS renin-angiotensin system","volume":"326","author":"von Bohlen und Halbach","year":"2006","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.phrs.2021.105515_bib10","first-page":"171","article-title":"Brain renin-angiotensin system in cognitive function: pre-clinical findings and implications for prevention and treatment of dementia","volume":"109","author":"Ciobica","year":"2009","journal-title":"Acta Neurol. Belg."},{"issue":"Suppl 4","key":"10.1016\/j.phrs.2021.105515_bib11","doi-asserted-by":"crossref","first-page":"S575","DOI":"10.3233\/JAD-141284","article-title":"Renin angiotensin aldosterone system inhibition in controlling dementia-related cognitive decline","volume":"42","author":"O\u2019Caoimh","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.phrs.2021.105515_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pneurobio.2011.07.001","article-title":"Brain renin-angiotensin--a new look at an old system","volume":"95","author":"Wright","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phrs.2021.105515_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1474-4422(19)30393-X","article-title":"Antihypertensive medications and risk for incident dementia and Alzheimer\u2019s disease: a meta-analysis of individual participant data from prospective cohort studies","volume":"19","author":"Ding","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2021.105515_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2016.05.003","article-title":"Renin-angiotensin system blockade use and risks of cognitive decline and dementia: a meta-analysis","volume":"624","author":"Zhuang","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2021.105515_bib15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2021.105515_bib16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1034\/j.1600-0404.106.s178.2.x","article-title":"Defining dementia: clinical criteria for the diagnosis of vascular dementia","volume":"Suppl. 178","author":"Rom\u00e1n","year":"2002","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.phrs.2021.105515_bib17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/HRP.0000000000000090","article-title":"DSM-5 and mental disorders in older individuals: an overview","volume":"23","author":"Sachdev","year":"2015","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.phrs.2021.105515_bib18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/WAD.0000000000000034","article-title":"Internationlal society for vascular behavioral and cognitive disorders, diagnostic criteria for vascular cognitive disorders: a VASCOG statement","volume":"28","author":"Sachdev","year":"2014","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.phrs.2021.105515_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.phrs.2021.105515_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin. Trials"},{"key":"10.1016\/j.phrs.2021.105515_bib21","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1002\/sim.1262","article-title":"A simple confidence interval for meta-analysis","volume":"21","author":"Sidik","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.phrs.2021.105515_bib22","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3758\/s13428-014-0527-2","article-title":"Meta-analysis of multiple outcomes: a multilevel approach","volume":"47","author":"Van den Noortgate","year":"2015","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.phrs.2021.105515_bib23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2021.105515_bib24","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archinternmed.2009.175","article-title":"Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the cardiovascular health study","volume":"169","author":"Sink","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.phrs.2021.105515_bib25","doi-asserted-by":"crossref","first-page":"b5465","DOI":"10.1136\/bmj.b5465","article-title":"Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis","volume":"340","author":"Li","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2021.105515_bib26","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-2011-110347","article-title":"Associations of anti-hypertensive treatments with Alzheimer\u2019s disease, vascular dementia, and other dementias","volume":"26","author":"Davies","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.phrs.2021.105515_bib27","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jalz.2011.05.2414","article-title":"Antihypertensive drug use and the risk of dementia in patients with diabetes mellitus","volume":"8","author":"Johnson","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.phrs.2021.105515_bib28","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1212\/WNL.0b013e3182a35228","article-title":"Ginkgo evaluation of memory (GEM) study investigators, antihypertensive drugs decrease risk of Alzheimer disease: ginkgo evaluation of memory study","volume":"81","author":"Yasar","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2021.105515_bib29","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/ajh\/hpw002","article-title":"High short-term blood pressure variability predicts long-term cardiovascular mortality in untreated hypertensives but not in normotensives","volume":"29","author":"Hsu","year":"2016","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.phrs.2021.105515_bib30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/bcp.12511","article-title":"Angiotensin receptor blockers and risk of dementia: cohort study in UK clinical practice research datalink","volume":"79","author":"Goh","year":"2015","journal-title":"Br. J. Clin. Pharm."},{"key":"10.1016\/j.phrs.2021.105515_bib31","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/HJH.0000000000000086","article-title":"Health data analysis in Taiwan (hDATa) research group, angiotension receptor blockers reduce the risk of dementia","volume":"32","author":"Chiu","year":"2014","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2021.105515_bib32","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1016\/j.neurobiolaging.2014.05.002","article-title":"Cache county investigators, use of diuretics is associated with reduced risk of Alzheimer\u2019s disease: the cache county study","volume":"35","author":"Chuang","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phrs.2021.105515_bib33","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1253\/circj.CJ-16-0692","article-title":"Calcium-channel blockers and dementia risk in older adults\u3000- national health insurance service - senior cohort (2002-2013)","volume":"80","author":"Hwang","year":"2016","journal-title":"Circ. J."},{"key":"10.1016\/j.phrs.2021.105515_bib34","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1212\/WNL.0000000000002946","article-title":"Dementia risk with antihypertensive use and blood pressure variability: a cohort study","volume":"87","author":"Tully","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2021.105515_bib35","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ijcard.2016.06.215","article-title":"Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers reduced dementia risk in patients with diabetes mellitus and hypertension","volume":"220","author":"Kuan","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.phrs.2021.105515_bib36","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1097\/HJH.0000000000001411","article-title":"Lower dementia risk with different classes of antihypertensive medication in older patients","volume":"35","author":"van Middelaar","year":"2017","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phrs.2021.105515_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206705","article-title":"The association of multiple anti-hypertensive medication classes with Alzheimer\u2019s disease incidence across sex, race, and ethnicity","volume":"13","author":"Barthold","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2021.105515_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3233\/JAD-190362","article-title":"The relationship between the use of antihypertensive drugs and the incidence of dementia in general practices in Germany","volume":"70","author":"Bohlken","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.phrs.2021.105515_bib39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ijcard.2016.06.215","article-title":"Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers reduced dementia risk in patients with diabetes mellitus and hypertension","volume":"220","author":"Kuan","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.phrs.2021.105515_bib40","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1471-4159.1982.tb07930.x","article-title":"Angiotensin converting enzyme in Alzheimer\u2019s disease increased activity in caudate nucleus and cortical areas","volume":"38","author":"Arregui","year":"1982","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2021.105515_bib41","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2990.2007.00885.x","article-title":"Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer\u2019s disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy","volume":"34","author":"Miners","year":"2008","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.phrs.2021.105515_bib42","first-page":"163","article-title":"Angiotensin-converting enzyme levels and activity in Alzheimer\u2019s disease: differences in brain and CSF ACE and association with ACE1 genotypes","volume":"1","author":"Miners","year":"2009","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.phrs.2021.105515_bib43","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3233\/JAD-190721","article-title":"Cerebrospinal fluid changes in the renin-angiotensin system in Alzheimer\u2019s disease","volume":"72","author":"Kehoe","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.phrs.2021.105515_bib44","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pbb.2015.04.002","article-title":"Hypertension exacerbates predisposition to neurodegeneration and memory impairment in the presence of a neuroinflammatory stimulus: protection by angiotensin converting enzyme inhibition","volume":"133","author":"Goel","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2021.105515_bib45","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1161\/01.RES.0000185804.79157.C0","article-title":"NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla","volume":"97","author":"Chan","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2021.105515_bib46","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0006-8993(89)90095-4","article-title":"Angiotensin II inhibits the release of [3H]acetylcholine from rat entorhinal cortex in vitro","volume":"491","author":"Barnes","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2021.105515_bib47","doi-asserted-by":"crossref","first-page":"876","DOI":"10.3390\/ijms19030876","article-title":"Within the brain: the renin angiotensin system","volume":"19","author":"Jackson","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2021.105515_bib48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00109-008-0316-4","article-title":"Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice","volume":"86","author":"Maul","year":"2008","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.phrs.2021.105515_bib49","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/jcbfm.2011.133","article-title":"Direct stimulation of angiotensin II type 2 receptor enhances spatial memory","volume":"32","author":"Jing","year":"2012","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.phrs.2021.105515_bib50","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.bbadis.2016.03.013","article-title":"Angiotensin II type-2 receptor stimulation induces neuronal VEGF synthesis after cerebral ischemia","volume":"1862","author":"Mateos","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2021.105515_bib51","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s13311-014-0286-x","article-title":"Angiotensin receptor type 2 activation induces neuroprotection and neurogenesis after traumatic brain injury","volume":"11","author":"Umschweif","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.phrs.2021.105515_bib52","doi-asserted-by":"crossref","first-page":"47863","DOI":"10.1074\/jbc.M104068200","article-title":"Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity","volume":"276","author":"Hu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.105515_bib53","doi-asserted-by":"crossref","first-page":"37644","DOI":"10.1074\/jbc.M508460200","article-title":"Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor","volume":"280","author":"Hemming","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.105515_bib54","doi-asserted-by":"crossref","first-page":"31914","DOI":"10.1074\/jbc.M109.011437","article-title":"Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme","volume":"284","author":"Zou","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.105515_bib55","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.vph.2006.05.002","article-title":"Molecular activation of PPARgamma by angiotensin II type 1-receptor antagonists","volume":"45","author":"Erbe","year":"2006","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105515_bib56","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbrc.2009.04.047","article-title":"PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons","volume":"383","author":"Du","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2021.105515_bib57","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1001\/archneurol.2012.1010","article-title":"Impact of angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series","volume":"69","author":"Hajjar","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.phrs.2021.105515_bib58","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/jamaneurol.2015.1001","article-title":"Association between angiotensin receptor blockers and longitudinal decline in tau in mild cognitive impairment","volume":"72","author":"Hajjar","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.phrs.2021.105515_bib59","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/jama.2018.21442","article-title":"Effect of intensive vs standard blood pressure control on probable dementia: a randomized clinical trial","volume":"321","author":"SPRINT MIND Investigators for the SPRINT Research Group","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2021.105515_bib60","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S1474-4422(20)30071-5","article-title":"Blood phosphorylated tau 181 as a biomarker for Alzheimer\u2019s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts","volume":"19","author":"Karikari","year":"2020","journal-title":"Lancet Neurol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821000992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821000992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:20:16Z","timestamp":1760912416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661821000992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":60,"alternative-id":["S1043661821000992"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105515","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between renin-angiotensin-aldosterone system inhibitors and risk of dementia: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105515","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105515"}}