{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:31:38Z","timestamp":1793403098325,"version":"4.5.0"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"am","delay-in-days":313,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012640","name":"ExxonMobil Foundation","doi-asserted-by":"publisher","award":["S18200000000256"],"award-info":[{"award-number":["S18200000000256"]}],"id":[{"id":"10.13039\/501100012640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006831","name":"U.S. Air Force","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006831","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550-19-1-0413"],"award-info":[{"award-number":["FA9550-19-1-0413"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.phrs.2021.105526","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T11:57:46Z","timestamp":1614686266000},"page":"105526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":205,"special_numbering":"C","title":["The hormetic dose-response mechanism: Nrf2 activation"],"prefix":"10.1016","volume":"167","author":[{"given":"Edward J.","family":"Calabrese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter J.","family":"Kozumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2021.105526_bib1","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.freeradbiomed.2013.08.190","article-title":"Sulforaphane preconditioning of the Nrf2\/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke","volume":"65","author":"Alfieri","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2021.105526_bib2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: pivotal roles inflammation","volume":"1863","author":"Ahmed","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2021.105526_bib3","series-title":"Thresholds of Genotoxic Carcinogens","first-page":"155","article-title":"Nrf2 as a possible determinant of the threshold for carcinogenesis","author":"Aoki","year":"2016"},{"key":"10.1016\/j.phrs.2021.105526_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1559325817699696","article-title":"Low-dose dose-response for in vitro Nrfs-ARE activation in human HepG2 cells","volume":"15","author":"Bogen","year":"2017","journal-title":"Dose-Response"},{"key":"10.1016\/j.phrs.2021.105526_bib5","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuro.2006.07.019","article-title":"In vivo modulation of the Parkinsonian phenotype by Nrf2","volume":"27","author":"Burton","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.phrs.2021.105526_bib6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/eesa.1998.1729","article-title":"Evidence that hormesis represents an \u201covercompensation\u201d response to a disruption in homeostasis","volume":"42","author":"Calabrese","year":"1999","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.phrs.2021.105526_bib7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/20014091111749","article-title":"Overcompensation stimulation: a mechanism for hormetic effects","volume":"31","author":"Calabrese","year":"2001","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.phrs.2021.105526_bib8","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1897\/07-541.1","article-title":"Hormesis: what does it means for toxicology and toxicologists","volume":"27","author":"Calabrese","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"issue":"7","key":"10.1016\/j.phrs.2021.105526_bib9","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3109\/10408444.2013.808172","article-title":"Hormetic mechanisms","volume":"43","author":"Calabrese","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.phrs.2021.105526_bib10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.phrs.2015.12.021","article-title":"Preconditioning is hormesis. Part 1. Preconditioning is hormesis: documentation, dose-response features and mechanistic foundations","volume":"110","author":"Calabrese","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.phrs.2015.12.020","article-title":"Preconditioning is hormesis. Part 2. How the conditioning dose mediates protection: dose optimization within temporal and mechanistic frameworks","volume":"110","author":"Calabrese","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib12","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/10807039709383710","article-title":"A quantitatively-based methodology for the evaluation of chemical hormesis","volume":"3","author":"Calabrese","year":"1997","journal-title":"Hum. Ecol. Risk Assess."},{"key":"10.1016\/j.phrs.2021.105526_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1191\/0960327102ht217oa","article-title":"Defining hormesis","volume":"21","author":"Calabrese","year":"2002","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.phrs.2021.105526_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yrtph.2011.06.003","article-title":"The hormesis data base: the occurrence of hormetic dose responses in the toxicological literature","volume":"61","author":"Calabrese","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105283","article-title":"The protective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis","volume":"163","author":"Calabrese","year":"2021","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41514-017-0013-z","article-title":"How does hormesis impact biology, toxicology and medicine?","volume":"3","author":"Calabrese","year":"2017","journal-title":"NPJ Aging Mech. Dis."},{"key":"10.1016\/j.phrs.2021.105526_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.envres.2018.12.020","article-title":"Estimating the range of the maximum hormetic stimulator response","volume":"170","author":"Calabrese","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib18","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.phrs.2018.10.010","article-title":"Hormesis mediates dose-sensitive shifts in macrophage activation patterns","volume":"137","author":"Calabrese","year":"2019","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib19","doi-asserted-by":"crossref","DOI":"10.1177\/1559325820936170","article-title":"Does green tea induce hormesis?","volume":"18","author":"Calabrese","year":"2020","journal-title":"Dose-Response"},{"key":"10.1016\/j.phrs.2021.105526_bib20","article-title":"Putative hormetic mechanisms and effects of atypical antipsychotic agents: implications for study design and clinical psychopharmacotherapeutics","author":"Calabrese","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phrs.2021.105526_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101273","article-title":"Demonstrated hormetic mechanisms subserve riluzole-induced effects in neuroprotection against amyotrophic lateral sclerosis (ALS): implications for research and clinical practice","volume":"67","author":"Calabrese","year":"2021","journal-title":"Aging Res. Rev."},{"key":"10.1016\/j.phrs.2021.105526_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tips.2018.10.010","article-title":"Building biological shields via hormesis","volume":"40","author":"Calabrese","year":"2019","journal-title":"Trends in Pharm. Sci."},{"key":"10.1016\/j.phrs.2021.105526_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.taap.2009.07.038","article-title":"Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells","volume":"241","author":"Chen","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib24","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1073\/pnas.0813361106","article-title":"Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson\u2019s disease","volume":"106","author":"Chen","year":"2009","journal-title":"PNAS"},{"key":"10.1016\/j.phrs.2021.105526_bib25","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1089\/ars.2012.4674","article-title":"Does Nrf2 contribute to p53-mediated control of cell survival and death?","volume":"17","author":"Chen","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phrs.2021.105526_bib26","doi-asserted-by":"crossref","first-page":"833","DOI":"10.7150\/ijbs.10564","article-title":"ROS\/autophagy\/Nrf2 pathway medicated low-dose radiation induced radio-resistance in human lung adenocarcinoma A549 cell","volume":"11","author":"Chen","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phrs.2021.105526_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mrgentox.2016.11.006","article-title":"Upregulation of Nrf2 through autophagy. ERK \u00bd ameliorates ionizing radiation induced cell death of human osteosarcoma U-2 OS","volume":"813","author":"Chen","year":"2017","journal-title":"Mutat. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1021\/tx400036v","article-title":"Bisphenol A activated the Nrf1\/2-antioxidant response element pathway in HEK 293 cells","volume":"26","author":"Chepelev","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.phrs.2021.105526_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41401-018-0154-z","article-title":"Ginsenoside Rg1 protects against ischemic\/reperfusion-induced neuronal injury through miR-144\/Nrf2\/Are pathway","volume":"40","author":"Chu","year":"2018","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phrs.2021.105526_bib30","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1007\/s12035-015-9451-4","article-title":"Sulforaphane ameliorates okadaic acid-induced memory impairment in rat by activating the Nrf2\/HO-1 antioxidant pathway","volume":"53","author":"Dwivedi","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2021.105526_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2012.08.017","article-title":"Age-related cataracts: homocyseine coupled endoplasmic reticulum stress and suppression of Nrfs-dependent antioxidant protection","volume":"200","author":"Elanchezchian","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phrs.2021.105526_bib32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/01480545.2018.1504961","article-title":"Luteolin protects microglia against rotenone-induced toxicity in a hormetic manner through targeting oxidative stress response, genes associated with Parkinson\u2019s disease and inflammatory pathways","volume":"43","author":"Elmazoglu","year":"2020","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.phrs.2021.105526_bib33","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1007\/s00204-019-02548-w","article-title":"Protective effect of methylene blue on TNBAS-induced colitis in rat mediated through the modulation of inflammatory and apoptotic signaling pathways","volume":"93","author":"El Sayed","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phrs.2021.105526_bib34","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/carcin\/bgi160","article-title":"Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-gentoci carcingoens","volume":"26","author":"Fukushima","year":"2005","journal-title":"Carcinogensis"},{"key":"10.1016\/j.phrs.2021.105526_bib35","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.freeradbiomed.2016.08.032","article-title":"The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40 \u00b0C) against heat shock-induced apoptosis","volume":"99","author":"Glory","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2021.105526_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.32725\/jab.2019.008","article-title":"Methylene blue elicits non-genotoxic 202 production and protects brain mitochondria from rotenone toxicity","volume":"17","author":"Gureev","year":"2019","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.phrs.2021.105526_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuint.2010.10.006","article-title":"Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopaine-indcue cytotoxicity","volume":"58","author":"Hara","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phrs.2021.105526_bib38","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1365-2443.2005.00905.x","article-title":"Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema","volume":"10","author":"Iizuka","year":"2005","journal-title":"Genes Cells"},{"key":"10.1016\/j.phrs.2021.105526_bib39","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.4049\/jimmunol.175.10.6968","article-title":"Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema","volume":"175","author":"Ishii","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2021.105526_bib40","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ejphar.2017.11.023","article-title":"Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons","volume":"818","author":"Izumi","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib41","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainres.2007.01.131","article-title":"Nrf-2 mediated protection against 6-hydoxydopame","volume":"1144","author":"Jakel","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2021.105526_bib42","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.bcp.2005.03.015","article-title":"Role of P13K\/Akt and MEK\/ERK signaling pathways in sulforaphane- and eurcin-induced phase II enzymes and MRP2 transcript, G2\/M arrest and cell death on caco-2 cells","volume":"69","author":"Jakubikova","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib43","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1089\/ars.2010.3731","article-title":"Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism","volume":"14","author":"Jazwa","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phrs.2021.105526_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.00029","article-title":"Hydrogen sulfide attenuates particulate matter-induced emphysema and airway inflammation through Nrf2-dependent manner","volume":"11","author":"Jia","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111717","article-title":"Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt\/Nrf2 signaling pathway","volume":"386","author":"Jia","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.phrs.2021.105526_bib46","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/jcb.25109","article-title":"Mechanism of dose-dependent regulation of UBE1L by polyphenols in human bronchial epithelial cells","volume":"116","author":"Jiang","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.phrs.2021.105526_bib47","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s11064-015-1751-6","article-title":"Neuroprotective effects of Tanshinone I against 6-OHDA-induced oxidative stress in cellular and mouse model of Parkinson\u2019s disease through upregulating Nrf2","volume":"41","author":"Jing","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/ars.2011.4491","article-title":"Targeting Nrf2-mediadated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson\u2019s disease","volume":"18","author":"Kaidery","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phrs.2021.105526_bib49","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/carcin\/bgp231","article-title":"Nrf2: friend or foe for chemoprevention?","volume":"31","author":"Kensler","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.phrs.2021.105526_bib50","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s12011-018-1280-7","article-title":"Boron affects the development of the kidney through modulation of apoptosis, antioxidant capacity, and Nrf2 pathway in the African Ostrich chicks","volume":"186","author":"Khaliq","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib51","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1177\/0960327120905962","article-title":"Upregulation of Nrf2-related cytoprotective genes expression b acetaminophen-induced acute hepatotoxity in mice and hepatotoxicity role of betaine","volume":"39","author":"Khodayar","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.phrs.2021.105526_bib52","doi-asserted-by":"crossref","first-page":"E2929","DOI":"10.1073\/pnas.1207718109","article-title":"Target of Nrf2 induces DA damage signaling and protects colonic epithelial cells from ionizing radiation","volume":"109","author":"Kim","year":"2012","journal-title":"PNAS"},{"key":"10.1016\/j.phrs.2021.105526_bib53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/13506129.2012.751367","article-title":"Amelioration of Alzheimer\u2019s disease by neuroprotective effects of sulforaphane in animal model","volume":"20","author":"Kim","year":"2013","journal-title":"Amyloid"},{"key":"10.1016\/j.phrs.2021.105526_bib54","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1667\/0033-7587(2002)157[0275:EOGIBL]2.0.CO;2","article-title":"Elevation of glutathione induced by low-dose gamma rays and its involvement in increased natural killer activity","volume":"157","author":"Kojima","year":"2002","journal-title":"Radiat. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib55","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1128\/JVI.00105-08","article-title":"Mice lacking the ISG 15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus","volume":"83","author":"Lai","year":"2009","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105526_bib56","doi-asserted-by":"crossref","DOI":"10.1177\/1559325818784501","article-title":"Enhancing and extending biological performance and resilience","volume":"16","author":"Leak","year":"2018","journal-title":"Dose-Response"},{"key":"10.1016\/j.phrs.2021.105526_bib57","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/313510","article-title":"Attenuation of beta-amyloid induced oxidative cell death by sulforaphane via activation of Nf-E2 related factor 2","author":"Lee","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phrs.2021.105526_bib58","first-page":"258","article-title":"Low-dose radiation activates Nrf1\/2 through reactive species and the Ca2+\/ERK1\/2 signaling pathway in human skin fibroblast cells","volume":"46","author":"Lee","year":"2013","journal-title":"BNB Rep."},{"key":"10.1016\/j.phrs.2021.105526_bib59","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.brainres.2017.03.018","article-title":"Neuroprotective effects of 2,4-dinitrophenol in an acute model of Parkinson\u2019s disease","volume":"1663","author":"Lee","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2021.105526_bib60","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1089\/ars.2018.7541","article-title":"Nuclear factor (erythroid-derived 2)-like 2 regulates the hepatoprotective effects of remote ischemia conditioning in hemorrhagic shock","volume":"30","author":"Leung","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phrs.2021.105526_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109669","article-title":"Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2\/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells","volume":"121","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phrs.2021.105526_bib62","first-page":"8004","article-title":"Zinc sulphate preconditioning alleviates rat myocardial hypoxia reoxygenation injury in vitro: activation of the Nrf\/ARE signaling pathway","volume":"10","author":"Li","year":"2017","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.phrs.2021.105526_bib63","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1016\/j.bmc.2018.09.010","article-title":"Discovery of natural flavonoids as activators of Nrf2-mediated defense system. Structure-activity relationship and inhibition of intracellular oxidative insults","volume":"26","author":"Li","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.phrs.2021.105526_bib64","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.taap.2018.09.002","article-title":"The effects of Nrf2 knockout on regulation of benzene-induced mouse hematotoxicity","volume":"358","author":"Li","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib65","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.freeradbiomed.2019.06.001","article-title":"Novel diterpenoid-type activators of the Keap1\/Nrf2\/ARE signaling pathway and their regulation of redox homeostasis","volume":"141","author":"Li","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2021.105526_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2016.12.001","article-title":"Anthraquinone derivative exerted hormetic effects on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2\/HO-1 signaling pathway","volume":"262","author":"Liu","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phrs.2021.105526_bib67","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3389\/fphar.2019.00792","article-title":"TTB protects astrocytes against oxygen-glucose deprivation\/reoxygenation-induced injury via activation of Nrf2\/HO-1 signaling pathway","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib68","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuropharm.2013.11.026","article-title":"Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2\/ARE signaling pathway","volume":"79","author":"Lou","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2021.105526_bib69","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3389\/fphar.2020.00466","article-title":"The protective effect of DiDang Tang against AlCl3-induced oxidative stress and apoptosis in PC12 cells through the activation of SIRT1-mediated Akt\/Nrf2\/HO-1 pathway","volume":"11","author":"Lu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib70","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.biopha.2017.01.151","article-title":"Ozone protects rat heart against ischemia-reperfusion injury: a role for oxidative preconditioning in attenuating mitochondrial injury","volume":"88","author":"Meng","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phrs.2021.105526_bib71","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3390\/nu10020250","article-title":"Metabolic responses in endothelial cells following exposure to ketone bodies","volume":"10","author":"Meroni","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2021.105526_bib72","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4062\/biomolther.2018.009","article-title":"Carbon monoxide ameliorate 6-hydroxydopaime-induice cell death in C6 glioma cells","volume":"26","author":"Moon","year":"2018","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.phrs.2021.105526_bib73","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.molmed.2004.09.003","article-title":"Nrf2-Keap1 defines a physiologically important stress response mechanisms","volume":"10","author":"Motohashi","year":"2004","journal-title":"Trends Mol. Med."},{"issue":"307","key":"10.1016\/j.phrs.2021.105526_bib74","first-page":"315","article-title":"Low doses of nanodiamonds and silica nonoparticles have beneficial hormetic effects in normal human skin fibroblasts in culture","volume":"148","author":"Mytych","year":"2016","journal-title":"Chemosphere"},{"issue":"97","key":"10.1016\/j.phrs.2021.105526_bib75","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.physbeh.2016.04.046","article-title":"How sodium arsenite improve amyloid \u03b2-induced memory deficit?","volume":"163","author":"Nassireslami","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.phrs.2021.105526_bib76","first-page":"1","article-title":"Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors","volume":"67","author":"Pall","year":"2015","journal-title":"Shengli Xuebao"},{"key":"10.1016\/j.phrs.2021.105526_bib77","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mrgentox.2018.04.007","article-title":"Early antioxidant responses via the concerted activated of NF-kappa B and Nrf2 characterize the concerted activation of NF-kapa B and Nrf2 characterize the gamma-radiation-induced adaptive response in quiescent human peripheral bold mononuclear cells","volume":"831","author":"Paraswani","year":"2018","journal-title":"Mutat. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.phrs.2021.105526_bib78","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.taap.2007.09.016","article-title":"Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid","volume":"226","author":"Pi","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib79","doi-asserted-by":"crossref","first-page":"10021","DOI":"10.1074\/jbc.M111.277145","article-title":"Nrf2-dependent induction of proteasome and Pa28aB regulator are required for adaptation to oxidative stress","volume":"287","author":"Pickering","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.105526_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/antiox7050063","article-title":"Anti-oxidant and anti-inflammatory activity of ketogenic diet: new perspectives for neuroprotectionin Alzheimer\u2019s Disease","volume":"7","author":"Pinto","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.phrs.2021.105526_bib81","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.redox.2017.02.007","article-title":"Role of Nrf2 and protective effects of metformin against tobacco smoke-induced cerebrovascular toxicity","volume":"12","author":"Prasad","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2021.105526_bib82","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.neuropharm.2011.11.012","article-title":"Potential roles of P13K\/AkT and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation","volume":"62","author":"Qi","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2021.105526_bib83","article-title":"Metformin protects ARPE-19 cells from glyoxal-induced oxidative stress","author":"Qu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phrs.2021.105526_bib84","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/nen.0b013e31802d6da9","article-title":"Expression of Nrf2 in neurodegenerative disease","volume":"66","author":"Ramsey","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.phrs.2021.105526_bib85","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pneurobio.2011.10.007","article-title":"Neurometabolic mechanism for memory enhancement and neuroprotection of methylene blue","volume":"96","author":"Rojas","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phrs.2021.105526_bib86","first-page":"588","article-title":"Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson\u2019s disease","volume":"58","author":"Rojo","year":"2010","journal-title":"Gila"},{"key":"10.1016\/j.phrs.2021.105526_bib87","series-title":"Radiation Hormesis and the Linear No-Threshold Dose Response","author":"Sanders","year":"2017"},{"key":"10.1016\/j.phrs.2021.105526_bib88","doi-asserted-by":"crossref","first-page":"2325e7","DOI":"10.1016\/j.neurobiolaging.2010.12.012","article-title":"Let we forget you-methylene blue","volume":"32","author":"Schirmer","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phrs.2021.105526_bib89","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.redox.2016.06.004","article-title":"A biphasic effect of TNF-a I regulation of the Keap 1\/Nrf2 pathway in cardiomyocytes","volume":"9","author":"Shanmugam","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2021.105526_bib90","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1089\/ars.2014.6074","article-title":"A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response","volume":"23","author":"Shen","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phrs.2021.105526_bib91","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s12192-019-01031-w","article-title":"Protodioscin protects PC12 cells against oxygen and glucose deprivation-induced injury through miR-124\/AKT\/Nfr2 pathway","volume":"24","author":"Shu","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.phrs.2021.105526_bib92","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1471-2407-13-253","article-title":"Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer","volume":"13","author":"Singh","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.phrs.2021.105526_bib93","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1113\/EP087122","article-title":"Ischemic and hypoxic conditioning: potential for protection of vital organs","volume":"104","author":"Sprick","year":"2019","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.phrs.2021.105526_bib94","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1093\/hmg\/ddu080","article-title":"Methylene blue upregulates Nrf2\/ARE and prevents tau-related neurotoxicity","volume":"23","author":"Stack","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2021.105526_bib95","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.bbrc.2014.03.081","article-title":"Adaptation to acrolein through upregulating the protection by glutathione inhuman bronchial epithelial cells: the materialization of the hormesis concept","volume":"446","author":"Sthijns","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2021.105526_bib96","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1007\/s11064-018-2672-y","article-title":"Nrf2 signaling elicits a neuroprotective role against PFOS-mediated oxidative damage and apoptosis","volume":"43","author":"Sun","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2795090","article-title":"The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases","volume":"2016","author":"Tan","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phrs.2021.105526_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/415078","article-title":"Sulforaphane as a potential protective phytochemical against neurodegenerative diseases","author":"Tarozzi","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phrs.2021.105526_bib99","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.expneurol.2014.09.021","article-title":"Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity","volume":"263","author":"Tsou","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2021.105526_bib100","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1269\/jrr.10002","article-title":"Low-dose gamma-ray irradiation induces translation of Nrf2 into nuclear in mouse macrophage location of Nrf2 into nuclear in mouse macrophage RaW264.7 cells","volume":"51","author":"Tsukimoto","year":"2010","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.phrs.2021.105526_bib101","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/mnfr.200900197","article-title":"Sulforaphane protects cortical neurons against 5-S-cysteinyldopamine-induced toxicity through the activation of ERK1\/2, Nrf-2 and the upregulation of detoxification enzymes","volume":"54","author":"Vauzour","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"issue":"11","key":"10.1016\/j.phrs.2021.105526_bib102","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1089\/ars.2010.3216","article-title":"When NRF2 talks, whose listening?","volume":"13","author":"Wakabayashi","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phrs.2021.105526_bib103","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/toxsci\/kfn201","article-title":"Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes","volume":"107","author":"Wang","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.phrs.2021.105526_bib104","doi-asserted-by":"crossref","first-page":"13478","DOI":"10.1021\/es502855x","article-title":"Iodoacetic acid activates Nrf2-mediated antioxidant responsein vitro and in vivo","volume":"48","author":"Wang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.phrs.2021.105526_bib105","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1667\/RR15575.1","article-title":"Cytoplasmic radiation induced radio-adaptive response in human lung fibroblast WI-38 cells","volume":"194","author":"Wang","year":"2020","journal-title":"Radiat. Res."},{"issue":"3","key":"10.1016\/j.phrs.2021.105526_bib106","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neuro.2012.01.015","article-title":"Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity","volume":"33","author":"Williamson","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.phrs.2021.105526_bib107","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.taap.2009.04.007","article-title":"Dose-dependent transition of Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages","volume":"238","author":"Woods","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib108","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12264-012-1273-z","article-title":"Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation\/reoxygenation via anti-apoptosis","volume":"28","author":"Wu","year":"2012","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.phrs.2021.105526_bib109","article-title":"Neuroprotection by curcumin in ischemic brain injury involves the Akt\/Nrf2 pathway","volume":"8","author":"Wu","year":"2013","journal-title":"PLOS One"},{"key":"10.1016\/j.phrs.2021.105526_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108741","article-title":"Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells","volume":"310","author":"Wu","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phrs.2021.105526_bib111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/291087","article-title":"Low-dose radiation activates AKT and Nrf2 in the kidney of diabetic mice: a potential mechanism to prevent diabetic nephropathy","volume":"2012","author":"Xing","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phrs.2021.105526_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101626","article-title":"Metformin alleviates lead-induced mitochondrial fragmentation via AMPK\/Nrf2 activation in SH-SY5Y cells","volume":"36","author":"Yang","year":"2020","journal-title":"Redox Biol."},{"issue":"13","key":"10.1016\/j.phrs.2021.105526_bib113","doi-asserted-by":"crossref","first-page":"10556","DOI":"10.1074\/jbc.M111.322420","article-title":"Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells","volume":"287","author":"Yeang","year":"2012","journal-title":"JBC"},{"key":"10.1016\/j.phrs.2021.105526_bib114","doi-asserted-by":"crossref","first-page":"28962","DOI":"10.1074\/jbc.272.46.28962","article-title":"Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated kinases","volume":"272","author":"Yu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.105526_bib115","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.taap.2009.04.005","article-title":"Phase 1 and II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses","volume":"237","author":"Zhang","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib116","doi-asserted-by":"crossref","first-page":"14396","DOI":"10.3390\/ijms150814396","article-title":"Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer\u2019s Disease-like lesions","volume":"15","author":"Zhang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2021.105526_bib117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.redox.2016.10.019","article-title":"Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving P13K\/AKT\/BCL-2 and Nrf2\/HO-1 pathway","volume":"11","author":"Zhang","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2021.105526_bib118","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mce.2015.12.012","article-title":"Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation","volume":"422","author":"Zhao","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phrs.2021.105526_bib119","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.toxlet.2017.04.011","article-title":"JWQ antagonizes paraquat-induced neurotoxicity via activation of Nr2a","volume":"277","author":"Zhao","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phrs.2021.105526_bib120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2018.01.046","article-title":"Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer\u2019s disease","volume":"824","author":"Zhao","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib121","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.biopha.2018.12.073","article-title":"Lycium barbarium polysaccharide reduces hyperoxic acute lung injury in mice throught Nrf2 pathway","volume":"111","author":"Zheng","year":"2019","journal-title":"Biomed. Pharmacol."},{"key":"10.1016\/j.phrs.2021.105526_bib122","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.redox.2017.09.004","article-title":"Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells","volume":"14","author":"Zhou","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2021.105526_bib123","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jff.2019.01.019","article-title":"(2 S)-5,6,7,3\u20324\u2032-pentametholxyflavanone, a citrus polymethoxyflavone ameliorates arsenic- and cigarette smoke extract-extract-induced cytotoxicity via activating Nrf2-mediaed defense system","volume":"54","author":"Zhou","year":"2019","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phrs.2021.105526_bib124","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1177\/0960327119842273","article-title":"Effect of fluoride on PERK-Nrf2 signaling pathway in mouse ameloblasts","volume":"38","author":"Zhou","year":"2019","journal-title":"Hum. Exp. Toxicol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821001109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821001109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:32:47Z","timestamp":1778581967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661821001109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":124,"alternative-id":["S1043661821001109"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105526","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The hormetic dose-response mechanism: Nrf2 activation","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105526"}}