{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:07:12Z","timestamp":1790755632448,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2016-I2M-3-007"],"award-info":[{"award-number":["2016-I2M-3-007"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2017-I2M-1-010"],"award-info":[{"award-number":["2017-I2M-1-010"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7182113"],"award-info":[{"award-number":["7182113"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1000905"],"award-info":[{"award-number":["2016YFC1000905"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX09711001-009-009"],"award-info":[{"award-number":["2018ZX09711001-009-009"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.phrs.2021.105650","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T12:49:20Z","timestamp":1620218960000},"page":"105650","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation"],"prefix":"10.1016","volume":"169","author":[{"given":"Nannan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengdi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2021.105650_bib1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s13311-011-0053-1","article-title":"Stroke epidemiology: advancing our understanding of disease mechanism and therapy","volume":"8","author":"Ovbiagele","year":"2011","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.phrs.2021.105650_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/jcbfm.2013.203","article-title":"Hemorrhagic transformation after ischemic stroke in animals and humans","volume":"34","author":"Jickling","year":"2014","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.phrs.2021.105650_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000504742","article-title":"Association between Red Blood Cell distribution width and hemorrhagic transformation in acute ischemic stroke patients","volume":"48","author":"Wang","year":"2019","journal-title":"Cereb. Dis."},{"key":"10.1016\/j.phrs.2021.105650_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/2396987319883461","article-title":"Diagnostic accuracy of computed tomography perfusion in the prediction of haemorrhagic transformation and patient outcome in acute ischaemic stroke: a systematic review and meta-analysis","volume":"5","author":"Adebayo","year":"2020","journal-title":"Eur. Stroke J."},{"key":"10.1016\/j.phrs.2021.105650_bib5","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.08.028","article-title":"Analysis of risk factors increased hemorrhagic transformation after acute ischemic stroke","volume":"27","author":"Ge","year":"2018","journal-title":"J. Stroke Cereb. Dis."},{"key":"10.1016\/j.phrs.2021.105650_bib6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.5551\/jat.RV16006","article-title":"Therapeutic strategies to attenuate hemorrhagic transformation after tissue plasminogen activator treatment for acute ischemic stroke","volume":"24","author":"Kanazawa","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.phrs.2021.105650_bib7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mehy.2017.08.017","article-title":"Hyperglycemia in acute ischemic stroke: is it time to re-evaluate our understanding?","volume":"107","author":"Reshi","year":"2017","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.phrs.2021.105650_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103818","article-title":"Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis","volume":"9","author":"Mishiro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.105650_bib9","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3389\/fneur.2019.01003","article-title":"Stress hyperglycemia and outcome of non-diabetic patients after acute ischemic stroke","volume":"10","author":"Zhu","year":"2019","journal-title":"Front Neurol."},{"key":"10.1016\/j.phrs.2021.105650_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fnagi.2019.00349","article-title":"Insulin-like growth factor-1 is neuroprotective in aged rats with ischemic stroke","volume":"11","author":"Serhan","year":"2019","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.phrs.2021.105650_bib11","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1007\/s12035-020-02016-y","article-title":"Proteomics-guided study on buyang huanwu decoction for its neuroprotective and neurogenic mechanisms for transient ischemic stroke: involvements of EGFR\/PI3K\/Akt\/Bad\/14-3-3 and Jak2\/Stat3\/Cyclin D1 signaling cascades","volume":"57","author":"Chen","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2021.105650_bib12","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3389\/fphar.2020.00822","article-title":"Efficacy and safety of xueshuantong injection on acute cerebral infarction: clinical evidence and GRADE assessment","volume":"11","author":"Lyu","year":"2020","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2021.105650_bib13","article-title":"Sailuotong capsule prevents the cerebral ischaemia-induced neuroinflammation and impairment of recognition memory through inhibition of LCN2 expression","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phrs.2021.105650_bib14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3736\/jcim20060117","article-title":"High-throughput screening assay for groups of effective components extracted from Xiaoxuming recipe","volume":"4","author":"Wang","year":"2006","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phrs.2021.105650_bib15","first-page":"2140","article-title":"Activity evaluation of components and preparation of effective components group of xiaoxuming decoction for anti-cerebral ischemia","volume":"36","author":"Wang","year":"2011","journal-title":"Chin. J. Chin. Mater. Med."},{"key":"10.1016\/j.phrs.2021.105650_bib16","first-page":"577","article-title":"GC and GC-MS rapid identification of total components and effective components in petroleum ether extracts of Xiaoxuming decoction","volume":"26","author":"Li","year":"2006","journal-title":"Chin. J. Pharm. Anal."},{"key":"10.1016\/j.phrs.2021.105650_bib17","first-page":"1111","article-title":"UPLC\/Q-TOF-MSE based analysis of chemical composition of AF-Xiao-Xu-Ming decoction","volume":"19","author":"Chen","year":"2017","journal-title":"Mod. Chin. Med"},{"key":"10.1016\/j.phrs.2021.105650_bib18","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.cclet.2014.09.001","article-title":"Rapid discovery and identification of 68 compounds in the active fraction from Xiao\u2013Xu\u2013Ming decoction (XXMD) by HPLC\u2013HRMS and MTSF technique","volume":"25","author":"Wang","year":"2014","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.phrs.2021.105650_bib19","first-page":"2139","article-title":"Effects of active components group of Xiaoxuming decoction on brain mitochondria in cerebral ischemia\/reperfusion rats during early recovery period","volume":"42","author":"Du","year":"2017","journal-title":"Chin. J. Chin. Mater. Med."},{"key":"10.1016\/j.phrs.2021.105650_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.5246\/jcps.2019.02.009","article-title":"Xiao-Xu-Ming decoction extract alleviates LPS-induced neuroinflammation associated with down-regulating TLR4\/MyD88 signaling pathway in vitro and in vivo","volume":"28","author":"Cheng","year":"2019","journal-title":"J. Chin. Pharm. Sci."},{"key":"10.1016\/j.phrs.2021.105650_bib21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4103\/1673-5374.245471","article-title":"Xiao-Xu-Ming decoction extract regulates differentially expressed proteins in the hippocampus after chronic cerebral hypoperfusion","volume":"14","author":"Wang","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phrs.2021.105650_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jns.2015.09.362","article-title":"A novel embolic middle cerebral artery occlusion model induced by thrombus formed in common carotid artery in rat","volume":"359","author":"Ma","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.phrs.2021.105650_bib23","first-page":"938","article-title":"Neuroprotective effect of active components of Xiaoxuming decoction on focal cerebral ischemia\/reperfusion injury in rats during early recovery period","volume":"32","author":"Lu","year":"2016","journal-title":"Chin. Pharm. Bull."},{"key":"10.1016\/j.phrs.2021.105650_bib24","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1742-2094-11-112","article-title":"Neutralization of chemokine-like factor 1, a novel C\u2013C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats","volume":"11","author":"Kong","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2021.105650_bib25","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1161\/01.STR.30.11.2280","article-title":"Hemorrhagic transformation within 36\u2009h of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort","volume":"30","author":"Fiorelli","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.phrs.2021.105650_bib26","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41401-020-00568-2","article-title":"Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway","volume":"42","author":"Liu","year":"2020","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phrs.2021.105650_bib27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1172\/JCI43144","article-title":"Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-\u03baB signaling","volume":"121","author":"Qu","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2021.105650_bib28","first-page":"448","article-title":"The role of pinocembrin in t-PA thrombolysis-induced hemorrhagic transformation","volume":"54","author":"Chen","year":"2019","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phrs.2021.105650_bib29","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3389\/fphar.2019.00264","article-title":"Perturbed lipidomic profiles in rats with chronic cerebral ischemia are regulated by Xiao-Xu-Ming decoction","volume":"10","author":"Jia","year":"2019","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2021.105650_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4147502","article-title":"Xiao-Xu-Ming decoction reduced mitophagy activation and improved mitochondrial function in cerebral ischemia and reperfusion injury","volume":"2018","author":"Lan","year":"2018","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.phrs.2021.105650_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s10020-019-0125-y","article-title":"The neuroprotective mechanisms of ginkgolides and bilobalide in cerebral ischemic injury: a literature review","volume":"25","author":"Feng","year":"2019","journal-title":"Mol. Med."},{"key":"10.1016\/j.phrs.2021.105650_bib32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.phymed.2018.05.003","article-title":"Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats","volume":"48","author":"Zeng","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phrs.2021.105650_bib33","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1097\/WNR.0000000000001072","article-title":"Effects of Ginkgo biloba extract on the cognitive function and expression profile of inflammatory factors in a rat model of hemorrhagic stroke","volume":"29","author":"Luo","year":"2018","journal-title":"Neuroreport"},{"key":"10.1016\/j.phrs.2021.105650_bib34","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.biopha.2018.04.125","article-title":"Investigation of Ginkgo biloba extract (EGb 761) promotes neurovascular restoration and axonal remodeling after embolic stroke in rat using magnetic resonance imaging and histopathological analysis","volume":"103","author":"Li","year":"2018","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phrs.2021.105650_bib35","article-title":"PI3K\/Akt pathway contributes to neurovascular unit protection of Xiao-Xu-Ming decoction against focal cerebral ischemia and reperfusion injury in rats","volume":"2013","author":"Lan","year":"2013","journal-title":"Evid. Based Complement Altern. Med"},{"key":"10.1016\/j.phrs.2021.105650_bib36","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3389\/fphar.2018.00926","article-title":"Beneficial role of rosuvastatin in blood-brain barrier damage following experimental ischemic stroke","volume":"9","author":"Lu","year":"2018","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2021.105650_bib37","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1208\/s12248-017-0091-7","article-title":"Blood-brain barrier protection as a therapeutic strategy for acute ischemic stroke","volume":"19","author":"Sifat","year":"2017","journal-title":"AAPS J."},{"key":"10.1016\/j.phrs.2021.105650_bib38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nbd.2008.08.005","article-title":"Blood-brain barrier tight junction permeability and ischemic stroke","volume":"32","author":"Sandoval","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phrs.2021.105650_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fneur.2013.00032","article-title":"Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke","volume":"4","author":"Lakhan","year":"2013","journal-title":"Front Neurol."},{"key":"10.1016\/j.phrs.2021.105650_bib40","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fncel.2016.00056","article-title":"Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke","volume":"10","author":"Turner","year":"2016","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.phrs.2021.105650_bib41","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3389\/fneur.2020.00473","article-title":"Matrix metalloproteinase-9 relationship with infarct growth and hemorrhagic transformation in the era of thrombectomy","volume":"11","author":"Mechtouff","year":"2020","journal-title":"Front Neurol."},{"key":"10.1016\/j.phrs.2021.105650_bib42","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1161\/STROKEAHA.116.015753","article-title":"Hyperbaric oxygen reduces infarction volume and hemorrhagic transformation through ATP\/NAD (+)\/Sirt1 pathway in hyperglycemic middle cerebral artery occlusion rats","volume":"48","author":"Hu","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.phrs.2021.105650_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116553","article-title":"Protective effect of dexmedetomidine against diabetic hyperglycemia-exacerbated cerebral ischemia\/reperfusion injury: an in vivo and in vitro study","volume":"235","author":"Chen","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2021.105650_bib44","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1161\/STROKEAHA.115.010557","article-title":"Hyperglycemia and PPAR\u03b3 antagonistically influence macrophage polarization and infarct healing after ischemic stroke","volume":"46","author":"Gliem","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.phrs.2021.105650_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8943210","article-title":"Pinocembrin protects blood-brain barrier function and expands the therapeutic time window for tissue-type plasminogen activator treatment in a rat thromboembolic stroke model","volume":"2018","author":"Ma","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phrs.2021.105650_bib46","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s12975-019-00772-1","article-title":"Glycyrrhizin prevents hemorrhagic transformation and improves neurological outcome in ischemic stroke with delayed thrombolysis through targeting peroxynitrite-mediated HMGB1 signaling","volume":"11","author":"Chen","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.phrs.2021.105650_bib47","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4103\/2045-9912.266987","article-title":"Hydrogen inhibits microglial activation and regulates microglial phenotype in a mouse middle cerebral artery occlusion model","volume":"9","author":"Huang","year":"2019","journal-title":"Med. Gas. Res."},{"key":"10.1016\/j.phrs.2021.105650_bib48","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1474-4422(18)30290-4","article-title":"Traditional Chinese medicine for ischaemic stroke","volume":"17","author":"Liu","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2021.105650_bib49","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phrs.2021.105650_bib50","doi-asserted-by":"crossref","first-page":"639","DOI":"10.21037\/atm.2019.10.70","article-title":"Wogonin improves functional neuroprotection for acute cerebral ischemia in rats by promoting angiogenesis via TGF-\u03b21","volume":"7","author":"Kong","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phrs.2021.105650_bib51","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4103\/1673-5374.247465","article-title":"Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway","volume":"14","author":"Bu","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phrs.2021.105650_bib52","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s10517-020-04859-w","article-title":"Mechanisms of neuroprotective action of hesperetin and carnosine in focal ischemia of the brain in rats","volume":"169","author":"Devyatov","year":"2020","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.phrs.2021.105650_bib53","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3389\/fphar.2020.00424","article-title":"Kaempferol protects against cerebral ischemia reperfusion injury through intervening oxidative and inflammatory stress induced apoptosis","volume":"11","author":"Wang","year":"2020","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2021.105650_bib54","doi-asserted-by":"crossref","first-page":"850","DOI":"10.14336\/AD.2017.0829","article-title":"The effects of baicalin and baicalein on cerebral ischemia: a review","volume":"8","author":"Liang","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.phrs.2021.105650_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108436","article-title":"Quercetin protects against cerebral ischemia\/reperfusion and oxygen glucose deprivation\/reoxygenation neurotoxicity","volume":"83","author":"Wang","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phrs.2021.105650_bib56","article-title":"Ephedrine attenuates cerebral ischemia\/reperfusion injury in rats through NF-\u03baB signaling pathway","author":"Shi","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.phrs.2021.105650_bib57","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/01.RES.84.5.489","article-title":"Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis","volume":"84","author":"Schmidt","year":"1999","journal-title":"Circ. Res"},{"key":"10.1016\/j.phrs.2021.105650_bib58","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2337\/db12-1528","article-title":"sRAGE and risk of diabetes, cardiovascular disease, and death","volume":"62","author":"Selvin","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2021.105650_bib59","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1161\/STROKEAHA.114.008336","article-title":"Receptor for advanced glycation end-product antagonist reduces blood-brain barrier damage after intracerebral hemorrhage","volume":"46","author":"Yang","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.phrs.2021.105650_bib60","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neuint.2011.12.008","article-title":"RAGE mediates vascular injury and inflammation after global cerebral ischemia","volume":"60","author":"Kamide","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phrs.2021.105650_bib61","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41598-018-37215-0","article-title":"Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation","volume":"9","author":"Hsieh","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2021.105650_bib62","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1182\/blood-2008-03-142760","article-title":"Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response","volume":"112","author":"Shi","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.phrs.2021.105650_bib63","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.atherosclerosis.2006.12.025","article-title":"High glucose induces plasminogen activator inhibitor-1 expression through Rho\/Rho-kinase-mediated NF-kappaB activation in bovine aortic endothelial cells","volume":"196","author":"Iwasaki","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.phrs.2021.105650_bib64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2015.10.035","article-title":"Blockade of high mobility group box-1 signaling via the receptor for advanced glycation end-products ameliorates inflammatory damage after acute intracerebral hemorrhage","volume":"609","author":"Li","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2021.105650_bib65","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1152\/physrev.00012.2018","article-title":"The Neutrophil\u2019s role during health and disease","volume":"99","author":"Liew","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2021.105650_bib66","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-0038-1677040","article-title":"Neutrophil extracellular traps in arterial and venous thrombosis","volume":"45","author":"Laridan","year":"2019","journal-title":"Semin Thromb. Hemost."},{"key":"10.1016\/j.phrs.2021.105650_bib67","doi-asserted-by":"crossref","first-page":"26554","DOI":"10.1038\/srep26554","article-title":"Honokiol suppresses TNF-\u03b1-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of I\u03baB\u03b1","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821002346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821002346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:27:42Z","timestamp":1760912862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661821002346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":67,"alternative-id":["S1043661821002346"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105650","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105650","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105650"}}