{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:50:39Z","timestamp":1793843439404,"version":"4.6.1"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.phrs.2021.105743","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T03:25:32Z","timestamp":1624677932000},"page":"105743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":114,"special_numbering":"C","title":["Role of epigenetic regulation in myocardial ischemia\/reperfusion injury"],"prefix":"10.1016","volume":"170","author":[{"given":"Keyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2021.105743_bib1","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","article-title":"Evolving therapies for myocardial ischemia\/reperfusion injury","volume":"65","author":"Ib\u00e1\u00f1ez","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1089253211436350","article-title":"Myocardial ischemia reperfusion injury: from basic science to clinical bedside","volume":"16","author":"Frank","year":"2012","journal-title":"Semin Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.phrs.2021.105743_bib3","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial reperfusion injury: looking beyond primary PCI","volume":"34","author":"Fr\u00f6hlich","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2021.105743_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","article-title":"Multitarget strategies to reduce myocardial ischemia\/reperfusion injury: JACCreviewtopicoftheweek","volume":"73","author":"Davidson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib5","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.117.310820","article-title":"Critical issues for the translation of cardioprotection","volume":"120","author":"Heusch","year":"2017","journal-title":"Circ. Res"},{"key":"10.1016\/j.phrs.2021.105743_bib6","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1093\/eurheartj\/ehy253","article-title":"Cardioprotection research must leave its comfort zone","volume":"39","author":"Heusch","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2021.105743_bib7","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/bph.12468","article-title":"Targeting mitochondrial cardiolipin and the cytochrome c\/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis","volume":"171","author":"Birk","year":"2014","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2021.105743_bib8","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/eurheartj\/ehv597","article-title":"EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention","volume":"37","author":"Gibson","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2021.105743_bib9","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.amjcard.2010.03.032","article-title":"Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy","volume":"103","author":"Turer","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41569-019-0235-9","article-title":"Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tcm.2012.12.006","article-title":"HDAC-dependent ventricular remodeling","volume":"23","author":"Xie","year":"2013","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.phrs.2021.105743_bib12","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pharmthera.2014.02.012","article-title":"Posttranslational modifications of histone deacetylases: implications for cardiovascular diseases","volume":"143","author":"Eom","year":"2014","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.phrs.2021.105743_bib13","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/CS20180465","article-title":"Histone acetylation and DNA methylation in ischemia\/reperfusion injury","volume":"133","author":"Tang","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.phrs.2021.105743_bib14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10557-019-06893-x","article-title":"The role of non-coding RNAs in ischemic myocardial reperfusion injury","volume":"33","author":"Siebert","year":"2019","journal-title":"Cardiovasc Drugs Ther."},{"key":"10.1016\/j.phrs.2021.105743_bib15","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.110.956839","article-title":"Epigenetic modifications: basic mechanisms and role in cardiovascular disease","volume":"123","author":"Handy","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2021.105743_bib16","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/CIRCRESAHA.118.312497","article-title":"Epigenetic modifications in cardiovascular aging and diseases","volume":"123","author":"Zhang","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2021.105743_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res"},{"key":"10.1016\/j.phrs.2021.105743_bib18","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.phrs.2021.105743_bib19","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/CIRCRESAHA.116.303630","article-title":"Readers, writers, and erasers: chromatin as the whiteboard of heart disease","volume":"116","author":"Gillette","year":"2015","journal-title":"Circ. Res"},{"key":"10.1016\/j.phrs.2021.105743_bib20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrm3890","article-title":"Histone core modifications regulating nucleosome structure and dynamics","volume":"15","author":"Tessarz","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2021.105743_bib21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-pharmtox-010611-134712","article-title":"Therapeutic potential for HDAC inhibitors in the heart","volume":"52","author":"McKinsey","year":"2012","journal-title":"Annu Rev. Pharm. Toxicol."},{"key":"10.1016\/j.phrs.2021.105743_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.taap.2016.07.003","article-title":"Role of histone deacetylases (HDACs) in progression and reversal of liver fibrosis","volume":"306","author":"Li","year":"2016","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.phrs.2021.105743_bib23","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.phrs.2021.105743_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s10020-018-0037-2","article-title":"Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia\/reperfusion injury","volume":"24","author":"Ling","year":"2018","journal-title":"Mol. Med"},{"key":"10.1016\/j.phrs.2021.105743_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.yjmcc.2017.12.004","article-title":"HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury","volume":"114","author":"Herr","year":"2018","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib26","first-page":"3129","article-title":"Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome","volume":"11","author":"Herr","year":"2003","journal-title":"Diabetes care"},{"key":"10.1016\/j.phrs.2021.105743_bib27","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cardiores.2003.09.031","article-title":"SC. Protein kinase activation and myocardial ischemia\/reperfusion injury","volume":"61","author":"Armstrong","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phrs.2021.105743_bib28","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1159\/000358686","article-title":"Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats","volume":"33","author":"Yang","year":"2014","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.phrs.2021.105743_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrcardio.2016.5","article-title":"Ischaemic conditioning and reperfusion injury","volume":"13","author":"Hausenloy","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2021.105743_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004076","article-title":"Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation","volume":"5","author":"Gidl\u00f6f","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.phrs.2021.105743_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pharmthera.2018.03.004","article-title":"Sirtuin activators and inhibitors: Promises, achievements, and challenges","volume":"188","author":"Dai","year":"2018","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.phrs.2021.105743_bib33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrm.2016.93","article-title":"Slowing ageing by design: the rise of NAD (+) and sirtuin-activating compounds","volume":"17","author":"Bonkowski","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2021.105743_bib34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pharmthera.2018.03.004","article-title":"Sirtuin activators and inhibitors: Promises, achievements, and challenges","volume":"188","author":"Dai","year":"2018","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.phrs.2021.105743_bib35","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1161\/CIRCULATIONAHA.110.958033","article-title":"Silent information regulator 1 protects the heart from ischemia\/reperfusion","volume":"122","author":"Hsu","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2021.105743_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12933-015-0299-8","article-title":"SIRT1 protects against myocardial ischemia-reperfusion injury via activating eNOS in diabetic rats","volume":"14","author":"Ding","year":"2015","journal-title":"Cardiovasc Diabetol."},{"key":"10.1016\/j.phrs.2021.105743_bib37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1139\/cjpp-2015-0152","article-title":"Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3","volume":"94","author":"Koentges","year":"2016","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.phrs.2021.105743_bib38","doi-asserted-by":"crossref","first-page":"H1602","DOI":"10.1152\/ajpheart.00027.2014","article-title":"SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts","volume":"306","author":"Porter","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phrs.2021.105743_bib39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijcard.2016.04.092","article-title":"Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia","volume":"215","author":"He","year":"2016","journal-title":"Int J. Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.yjmcc.2015.03.017","article-title":"Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D","volume":"84","author":"Bochaton","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib41","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1016\/j.febslet.2008.07.016","article-title":"SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cells","volume":"582","author":"Lynn","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phrs.2021.105743_bib42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbrc.2018.05.113","article-title":"Amelioration of myocardial ischemia-reperfusion injury by SIRT4 involves mitochondrial protection and reduced apoptosis","volume":"502","author":"Zeng","year":"2018","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.phrs.2021.105743_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yjmcc.2015.09.005","article-title":"Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury","volume":"88","author":"Boylston","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00395-016-0531-z","article-title":"SIRT6 protects cardiomyocytes against ischemia\/reperfusion injury by augmenting FoxO3\u03b1-dependent antioxidant defense mechanisms","volume":"111","author":"Wang","year":"2016","journal-title":"Basic Res Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib45","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCRESAHA.107.164558","article-title":"Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice","volume":"102","author":"Vakhrusheva","year":"2008","journal-title":"Circ. Res"},{"key":"10.1016\/j.phrs.2021.105743_bib46","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/jpi.12267","article-title":"Melatonin: an ancient molecule that makes oxygen metabolically tolerable","volume":"59","author":"Manchester","year":"2015","journal-title":"J. Pineal Res"},{"key":"10.1016\/j.phrs.2021.105743_bib47","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.ijcard.2016.07.108","article-title":"Melatonin effects on myocardial ischemia-reperfusion injury: Impact on the outcome in patients undergoing coronary artery bypass grafting surgery","volume":"221","author":"Dwaich","year":"2016","journal-title":"Int J. Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib48","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12419","article-title":"Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis","volume":"63","author":"Zhai","year":"2017","journal-title":"J. Pineal Res"},{"key":"10.1016\/j.phrs.2021.105743_bib49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"Kahn","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2021.105743_bib50","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature08778","article-title":"SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation","volume":"464","author":"Hirschey","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.105743_bib51","doi-asserted-by":"crossref","first-page":"41337","DOI":"10.1038\/srep41337","article-title":"Melatonin ameliorates myocardial ischemia\/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1\u03b1-SIRT3 signaling","volume":"7","author":"Yu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2021.105743_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6803943","article-title":"Dihydromyricetin ameliorates cardiac ischemia\/reperfusion injury through Sirt3 activation","volume":"2019","author":"Wei","year":"2019","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.phrs.2021.105743_bib53","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3389\/fphar.2018.00722","article-title":"3-Bromo-4,5-dihydroxybenzaldehyde protects against myocardial ischemia and reperfusion injury through the Akt-PGC1\u03b1-Sirt3 pathway","volume":"9","author":"Qin","year":"2018","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2021.105743_bib54","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.phrs.2017.03.001","article-title":"Curcumin as a potential protective compound against cardiac diseases","volume":"119","author":"Jiang","year":"2017","journal-title":"Pharm. Res"},{"key":"10.1016\/j.phrs.2021.105743_bib55","first-page":"1150","article-title":"Curcumin attenuates IR-induced myocardial injury by activating SIRT3","volume":"22","author":"Wang","year":"2018","journal-title":"Eur. Rev. Med Pharm. Sci."},{"key":"10.1016\/j.phrs.2021.105743_bib56","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.intimp.2019.03.056","article-title":"Trans sodium crocetinate alleviates ischemia\/reperfusion-induced myocardial oxidative stress and apoptosis via the SIRT3\/FOXO3a\/SOD2 signaling pathway","volume":"71","author":"Chang","year":"2019","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.phrs.2021.105743_bib57","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1161\/CIRCRESAHA.109.209338","article-title":"Protein acetylation in the cardiorenal axis: the promise of histone deacetylase inhibitors","volume":"106","author":"Bush","year":"2010","journal-title":"Circ. Res"},{"key":"10.1016\/j.phrs.2021.105743_bib58","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd4360","article-title":"Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders","volume":"13","author":"Falkenberg","year":"2014","journal-title":"Nat. Rev. Drug Disco"},{"key":"10.1016\/j.phrs.2021.105743_bib59","doi-asserted-by":"crossref","first-page":"H968","DOI":"10.1152\/ajpheart.00891.2006","article-title":"Inhibition of histone deacetylase on ventricular remodeling in infarcted rats","volume":"293","author":"Lee","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phrs.2021.105743_bib60","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1096\/fj.08-108548","article-title":"deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice","volume":"10","author":"Granger","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.phrs.2021.105743_bib61","doi-asserted-by":"crossref","first-page":"H1834","DOI":"10.1152\/ajpheart.00435.2005","article-title":"Ontogeny of phosphoinositide 3-kinase signaling in developing heart: effect of acute beta-adrenergic stimulation","volume":"5","author":"Tseng","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phrs.2021.105743_bib62","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/01.CIR.104.3.330","article-title":"Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo","volume":"3","author":"Matsui","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2021.105743_bib63","doi-asserted-by":"crossref","first-page":"65474","DOI":"10.1371\/journal.pone.0065474","article-title":"HDAC inhibition elicits myocardial protective effect through modulation of MKK3\/Akt-1","volume":"8","author":"Zhao","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.phrs.2021.105743_bib64","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.arcmed.2012.04.007","article-title":"Trichostatin A ameliorates myocardial ischemia\/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis","volume":"43","author":"Yu","year":"2012","journal-title":"Arch. Med Res"},{"key":"10.1016\/j.phrs.2021.105743_bib65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1748-1716.2007.01780.x","article-title":"FOXO transcription factors in ageing and cancer","volume":"192","author":"Greer","year":"2008","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.phrs.2021.105743_bib66","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8208065","article-title":"Suppression of excessive histone deacetylases activity in diabetic hearts attenuates myocardial ischemia\/reperfusion injury via mitochondria apoptosis pathway","volume":"2017","author":"Wu","year":"2017","journal-title":"J. Diabetes Res"},{"key":"10.1016\/j.phrs.2021.105743_bib67","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3892\/ijmm.2017.3101","article-title":"TrichostatinA attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway","volume":"40","author":"Guo","year":"2017","journal-title":"Int J. Mol. Med"},{"key":"10.1016\/j.phrs.2021.105743_bib68","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/CIRCULATIONAHA.113.002416","article-title":"Histone deacetylase inhibition blunts ischemia\/reperfusion injury by inducing cardiomyocyte autophagy","volume":"129","author":"Xie","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2021.105743_bib69","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yjmcc.2011.04.005","article-title":"Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension","volume":"51","author":"Lemon","year":"2011","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.phrs.2021.105743_bib70","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1073\/pnas.0803749105","article-title":"HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation","volume":"105","author":"Parmigiani","year":"2008","journal-title":"Proc. Natl. Acad. Sci. Usa."},{"key":"10.1016\/j.phrs.2021.105743_bib71","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9494052","article-title":"Inhibition of HDAC6 activity alleviates myocardial ischemia\/reperfusion injury in diabetic rats: potential role of peroxiredoxin 1 acetylation and redox regulation","volume":"2018","author":"Leng","year":"2018","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.phrs.2021.105743_bib72","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrurol.2010.185","article-title":"The epigenome as a therapeutic target in prostate cance","volume":"7","author":"Perry","year":"2010","journal-title":"Nat. Rev. Urol."},{"issue":"218","key":"10.1016\/j.phrs.2021.105743_bib73","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1242\/jeb.107961","article-title":"New insights into mechanisms that regulate DNA methylation patterning","volume":"218","author":"Ficz","year":"2015","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.phrs.2021.105743_bib74","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2021.105743_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101444","article-title":"DNA hypermethylation: A novel mechanism of CREG gene suppression and atherosclerogenic endothelial dysfunction","volume":"32","author":"Liu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2021.105743_bib76","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.3892\/mmr.2016.5120","article-title":"Integration of gene expression and DNA methylation profiles provides a molecular subtype for risk assessment in atherosclerosis","volume":"13","author":"Ma","year":"2016","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.phrs.2021.105743_bib77","doi-asserted-by":"crossref","first-page":"76865","DOI":"10.18632\/oncotarget.20172","article-title":"Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring","volume":"8","author":"Ke","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.phrs.2021.105743_bib78","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1074\/jbc.M112.391680","article-title":"Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons","volume":"288","author":"Rakovic","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.105743_bib79","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrm.2017.129","article-title":"Building and decoding ubiquitin chains for mitophagy","volume":"19","author":"Harper","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2021.105743_bib80","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/s41418-018-0206-4","article-title":"The circular RNA ACR attenuates myocardial ischemia\/reperfusion injury by suppressing autophagy via modulation of the Pink1\/ FAM65B pathway","volume":"26","author":"Zhou","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2021.105743_bib81","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1093\/eurheartj\/ehx165","article-title":"Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives","volume":"39","author":"Poller","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phrs.2021.105743_bib82","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1042\/BCJ20170280","article-title":"The role of interactions of long non-coding RNAs and heterogeneous nuclear ribonucleoproteins in regulating cellular functions","volume":"474","author":"Sun","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.phrs.2021.105743_bib83","doi-asserted-by":"crossref","first-page":"23651","DOI":"10.3390\/ijms161023651","article-title":"Long non-coding RNAs as master regulators in cardiovascular diseases","volume":"16","author":"Archer","year":"2015","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2021.105743_bib84","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.canlet.2015.06.003","article-title":"Circular RNA: a new star of noncoding RNAs","volume":"365","author":"Qu","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2021.105743_bib85","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2021.105743_bib86","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1159\/000489149","article-title":"Inhibition of LncRNA-HRIM increases cell viability by regulating autophagy levels during hypoxia\/reoxygenation in myocytes","volume":"46","author":"Huang","year":"2018","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.phrs.2021.105743_bib87","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2097954","article-title":"Expression profiles and ontology analysis of circular RNAs in a mouse model of myocardial ischemia\/reperfusion injury","volume":"2020","author":"Sun","year":"2020","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.phrs.2021.105743_bib88","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1002\/jcb.27663","article-title":"MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1","volume":"120","author":"Yang","year":"2019","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phrs.2021.105743_bib89","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncomms1981","article-title":"Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis","volume":"3","author":"Lee","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2021.105743_bib90","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2021.105743_bib91","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/CIRCRESAHA.117.305781","article-title":"MicroRNA-103\/107 regulate programmed necrosis and myocardial ischemia\/reperfusion injury through targeting FADD","volume":"117","author":"Wang","year":"2015","journal-title":"Circ. Res"},{"key":"10.1016\/j.phrs.2021.105743_bib92","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the PTEN tumour suppressor: new modes and prospects","volume":"19","author":"Lee","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2021.105743_bib93","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1146\/annurev-biochem-082411-113907","article-title":"PTEN","volume":"83","author":"Worby","year":"2014","journal-title":"Annu Rev. Biochem"},{"key":"10.1016\/j.phrs.2021.105743_bib94","doi-asserted-by":"crossref","first-page":"9106","DOI":"10.1590\/1414-431x20199106","article-title":"miR-26a-5p protects against myocardial ischemia\/reperfusion injury by regulating the PTEN\/PI3K\/AKT signaling pathway","volume":"53","author":"Xing","year":"2020","journal-title":"Braz. J. Med Biol. Res"},{"key":"10.1016\/j.phrs.2021.105743_bib95","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1590\/1414-431x20186555","article-title":"Long non-coding RNA-ROR aggravates myocardial ischemia\/reperfusion injury","volume":"51","author":"Zhang","year":"2018","journal-title":"Braz. J. Med Biol. Res"},{"key":"10.1016\/j.phrs.2021.105743_bib96","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.3892\/mmr.2020.11597","article-title":"Silencing of long non-coding RNA HRIM protects against myocardial ischemia\/reperfusion injury via inhibition of NF-\u03baB signaling","volume":"22","author":"Niu","year":"2020","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.phrs.2021.105743_bib97","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/cdd.2016.28","article-title":"The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873","volume":"23","author":"Wang","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2021.105743_bib98","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.atherosclerosis.2018.08.031","article-title":"Long non-coding RNA nuclear-enriched abundant transcript 1 inhibition blunts myocardial ischemia reperfusion injury via autophagic flux arrest and apoptosis in streptozotocin-induced diabetic rats","volume":"277","author":"Ma","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.phrs.2021.105743_bib99","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/15384047.2019.1665393","article-title":"MiR-133a-5p inhibits androgen receptor (AR)-induced proliferation in prostate cancer cells via targeting FUsed in Sarcoma (FUS) and AR","volume":"21","author":"Zheng","year":"2020","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.phrs.2021.105743_bib100","first-page":"6323","article-title":"Circ-100338 induces angiogenesis after myocardial ischemia-reperfusion injury by sponging miR-200a-3p","volume":"24","author":"Chang","year":"2020","journal-title":"Eur. Rev. Med Pharm. Sci."},{"key":"10.1016\/j.phrs.2021.105743_bib101","first-page":"6980","article-title":"Hsa-circ-0068566 inhibited the development of myocardial ischemia reperfusion injury by regulating hsa-miR-6322\/PARP2 signal pathway","volume":"24","author":"Zhou","year":"2020","journal-title":"Eur. Rev. Med Pharm. Sci."},{"key":"10.1016\/j.phrs.2021.105743_bib102","first-page":"6980","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Eur. Rev. Med Pharm. Sci."},{"key":"10.1016\/j.phrs.2021.105743_bib103","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phrs.2021.105743_bib104","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrg.2016.59","article-title":"The molecular hallmarks of epigenetic control","volume":"17","author":"Allis","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.phrs.2021.105743_bib105","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","article-title":"FTO-Dependent N (6)-methyladenosine regulates cardiac function during remodeling and repair","volume":"139","author":"Mathiyalagan","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2021.105743_bib106","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1080\/15548627.2019.1586246","article-title":"METTL3 and ALKBH5 oppositely regulate m (6)A modification of TFEB mRNA, which dictates the fate of hypoxia\/reoxygenation-treated cardiomyocytes","volume":"15","author":"Song","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2021.105743_bib107","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/aps.2018.19","article-title":"Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro","volume":"39","author":"Ruan","year":"2018","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phrs.2021.105743_bib108","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/aps.2018.18","article-title":"Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro","volume":"39","author":"Ruan","year":"2018","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phrs.2021.105743_bib109","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.yjmcc.2020.11.011","article-title":"The cardiac methylome: a hidden layer of RNA modifications to regulate gene expression","volume":"152","author":"Rajan","year":"2020","journal-title":"J. Mol. Cell Cardiol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821003273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821003273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:32:31Z","timestamp":1760913151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661821003273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":109,"alternative-id":["S1043661821003273"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105743","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of epigenetic regulation in myocardial ischemia\/reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105743","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105743"}}