{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:38:51Z","timestamp":1790516331573,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["18714"],"award-info":[{"award-number":["18714"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Airc Italian Foundation for Cancer Research","doi-asserted-by":"publisher","award":["M FAG#1871 4"],"award-info":[{"award-number":["M FAG#1871 4"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.phrs.2021.105750","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T02:20:26Z","timestamp":1625019626000},"page":"105750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy"],"prefix":"10.1016","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-8160","authenticated-orcid":false,"given":"Marco","family":"Spreafico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cafora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5420-6018","authenticated-orcid":false,"given":"Cinzia","family":"Bragato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7701-728X","authenticated-orcid":false,"given":"Daniele","family":"Capitanio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Marasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Bodega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-7414","authenticated-orcid":false,"given":"Clara","family":"De Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-2320","authenticated-orcid":false,"given":"Marina","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Gelfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9467-2542","authenticated-orcid":false,"given":"Anna","family":"Pistocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2021.105750_bib1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0092-8674(87)90579-4","article-title":"Dystrophin: the protein product of the duchenne muscular dystrophy locus","volume":"51","author":"Hoffman","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2021.105750_bib2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/gt.2014.53","article-title":"Exon skipping restores dystrophin expression, but fails to prevent disease progression in later stage dystrophic dko mice","volume":"21","author":"Wu","year":"2014","journal-title":"Gene Ther."},{"key":"10.1016\/j.phrs.2021.105750_bib3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10654-020-00613-8","article-title":"Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis","volume":"35","author":"Landfeldt","year":"2020","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.phrs.2021.105750_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11940-014-0287-4","article-title":"Current treatment and management of dystrophinopathies","volume":"16","author":"Goemans","year":"2014","journal-title":"Curr. Treat. Options Neurol."},{"key":"10.1016\/j.phrs.2021.105750_bib5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5966\/sctm.2015-0266","article-title":"Concise review: epigenetic regulation of myogenesis in health and disease","volume":"5","author":"Sincennes","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.phrs.2021.105750_bib6","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1073\/pnas.112218599","article-title":"Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases","volume":"99","author":"Iezzi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2021.105750_bib7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1534-5807(04)00107-8","article-title":"Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin","volume":"6","author":"Iezzi","year":"2004","journal-title":"Dev. Cell."},{"key":"10.1016\/j.phrs.2021.105750_bib8","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nm1479","article-title":"Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors","volume":"12","author":"Minetti","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2021.105750_bib9","doi-asserted-by":"crossref","first-page":"19183","DOI":"10.1073\/pnas.0805514105","article-title":"HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment","volume":"105","author":"Colussi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2021.105750_bib10","article-title":"The HDAC inhibitor TSA Ameliorates a zebrafish model of duchenne muscular dystrophy","volume":"5","author":"Johnson","year":"2013","journal-title":"PLoS Curr."},{"key":"10.1016\/j.phrs.2021.105750_bib11","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.str.2004.04.012","article-title":"Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases","volume":"12","author":"Somoza","year":"2004","journal-title":"Structure"},{"key":"10.1016\/j.phrs.2021.105750_bib12","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/leu.2008.9","article-title":"A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas","volume":"22","author":"Balasubramanian","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.phrs.2021.105750_bib13","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ejmech.2018.03.002","article-title":"Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors","volume":"150","author":"Zhao","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phrs.2021.105750_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.stem.2015.08.004","article-title":"HDAC8 inhibition specifically targets Inv(16) acute myeloid leukemic stem cells by restoring p53 acetylation","volume":"17","author":"Qi","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phrs.2021.105750_bib15","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.18632\/oncotarget.6427","article-title":"Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability","volume":"7","author":"Chao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.phrs.2021.105750_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0133302","article-title":"HDAC8, A potential therapeutic target for the treatment of malignant peripheral nerve sheath tumors (MPNST)","volume":"10","author":"Lopez","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.105750_bib17","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1158\/0008-5472.CAN-14-3786","article-title":"Histone deacetylase HDAC8 promotes insulin resistance and \u03b2-catenin activation in NAFLD-associated hepatocellular carcinoma","volume":"75","author":"Tian","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2021.105750_bib18","article-title":"The HDAC inhibitor TSA ameliorates a zebrafish model of duchenne muscular dystrophy","volume":"5","author":"Johnson","year":"2013","journal-title":"PLoS Curr."},{"key":"10.1016\/j.phrs.2021.105750_bib19","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1242\/dev.00799","article-title":"Dystrophin is required for the formation of stable muscle attachments in the zebrafish embryo","volume":"130","author":"Bassett","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.phrs.2021.105750_bib20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/hmg\/ddg071","article-title":"The dystrophin associated protein complex in zebrafish","volume":"12","author":"Guyon","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2021.105750_bib21","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/j.ddtec.2012.03.001","article-title":"Zebrafish based small molecule screens for novel DMD drugs","volume":"10","author":"Kawahara","year":"2013","journal-title":"Drug Discov. Today.: Technol."},{"key":"10.1016\/j.phrs.2021.105750_bib22","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.nmd.2010.08.004","article-title":"Dystrophin-deficient zebrafish feature aspects of the Duchenne muscular dystrophy pathology","volume":"20","author":"Berger","year":"2010","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.phrs.2021.105750_bib23","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1073\/pnas.1102116108","article-title":"Drug screening in a zebrafish model of duchenne muscular dystrophy","volume":"108","author":"Kawahara","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2021.105750_bib24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.matbio.2007.06.004","article-title":"Altered extracellular matrix transcript expression and protein modulation in primary Duchenne muscular dystrophy myotubes","volume":"26","author":"Zanotti","year":"2007","journal-title":"Matrix Biol."},{"key":"10.1016\/j.phrs.2021.105750_bib25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/dbio.1997.8779","article-title":"High-frequency generation of transgenic zebrafish which reliably express GFP in whole muscles or the whole body by using promoters of zebrafish origin","volume":"192","author":"ichi Higashijima","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.phrs.2021.105750_bib26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.phrs.2021.105750_bib27","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3389\/fcell.2020.00844","article-title":"HDAC8: a promising therapeutic target for acute myeloid leukemia","volume":"8","author":"Spreafico","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phrs.2021.105750_bib28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/hmg\/ddp528","article-title":"Zebrafish models for human FKRP muscular dystrophies","volume":"19","author":"Kawahara","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2021.105750_bib29","doi-asserted-by":"crossref","DOI":"10.3791\/50925-v","article-title":"Analysis of skeletal muscle defects in larval zebrafish by birefringence and touch-evoke escape response assays","author":"Smith","year":"2013","journal-title":"JoVE"},{"key":"10.1016\/j.phrs.2021.105750_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13395-020-00251-4","article-title":"A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy","volume":"10","author":"Farr","year":"2020","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.phrs.2021.105750_bib31","doi-asserted-by":"crossref","first-page":"75404","DOI":"10.1371\/journal.pone.0075404","article-title":"Optimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid in vivo bioactivity analysis of anti-inflammatory secondary metabolites","volume":"8","author":"Cordero-Maldonado","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.105750_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phrs.2021.105750_bib33","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/dev.000067","article-title":"Dynamic somite cell rearrangements lead to distinct waves of myotome growth","volume":"134","author":"Stellabotte","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.phrs.2021.105750_bib34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00441-010-0976-6","article-title":"Elevated satellite cell number in Duchenne muscular dystrophy","volume":"340","author":"Kottlors","year":"2010","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.phrs.2021.105750_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/438675","article-title":"From innate to adaptive immune response in muscular dystrophies and skeletal muscle regeneration: the role of lymphocytes","volume":"2014","author":"Madaro","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phrs.2021.105750_bib36","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/j.1600-0854.2007.00622.x","article-title":"rAAV6-Microdystrophin rescues aberrant Golgi complex organization in mdx skeletal muscles","volume":"8","author":"Percival","year":"2007","journal-title":"Traffic"},{"key":"10.1016\/j.phrs.2021.105750_bib37","first-page":"1","article-title":"Hypoxia destroys the microstructure of microtubules and causes dysfunction of endothelial cells via the PI3K \/ Stathmin1 pathway","author":"Cao","year":"2019","journal-title":"Cell Biosci."},{"key":"10.1016\/j.phrs.2021.105750_bib38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2119\/molmed.2011.00049","article-title":"Histone deacetylase inhibitors in the treatment of muscular dystrophies: epigenetic drugs for genetic diseases","volume":"17","author":"Consalvi","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.phrs.2021.105750_bib39","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.3390\/ph3092751","article-title":"Clinical toxicities of histone deacetylase inhibitors","volume":"3","author":"Subramanian","year":"2010","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"key":"10.1016\/j.phrs.2021.105750_bib40","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/cddis.2015.24","article-title":"Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation","volume":"6","author":"Rettig","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phrs.2021.105750_bib41","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1517\/17460441.2014.927435","article-title":"Recent advances using zebrafish animal models for muscle disease drug discovery","volume":"9","author":"Maves","year":"2014","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.phrs.2021.105750_bib42","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/emmm.201202096","article-title":"Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice","volume":"5","author":"Mozzetta","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.phrs.2021.105750_bib43","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2141.2010.08266.x","article-title":"A pilot study of the Histone-Deacetylase inhibitor Givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms","volume":"150","author":"Rambaldi","year":"2010","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.phrs.2021.105750_bib44","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1002\/jcp.27341","article-title":"HDAC8 regulates canonical Wnt pathway to promote differentiation in skeletal muscles","volume":"234","author":"Ferrari","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phrs.2021.105750_bib45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature11316","article-title":"HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle","volume":"489","author":"Deardorff","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.105750_bib46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.molcel.2018.06.008","article-title":"A muscle-specific enhancer RNA mediates cohesin recruitment and regulates transcription in trans","volume":"71","author":"Tsai","year":"2018","journal-title":"Mol. Cell."},{"key":"10.1016\/j.phrs.2021.105750_bib47","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2443.2007.01052.x","article-title":"c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases","volume":"12","author":"Kobayashi","year":"2007","journal-title":"Genes Cells"},{"key":"10.1016\/j.phrs.2021.105750_bib48","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1101\/gad.234468.113","article-title":"HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles","volume":"28","author":"Saccone","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.phrs.2021.105750_bib49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12964-018-0231-4","article-title":"Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6","volume":"16","author":"Vanaja","year":"2018","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phrs.2021.105750_bib50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1083\/jcb.200905048","article-title":"Dystrophin is a microtubule-associated protein","volume":"186","author":"Prins","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2021.105750_bib51","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/scisignal.2002829","article-title":"Microtubules underlie dysfunction in duchenne muscular dystrophy","volume":"5","author":"Khairallah","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.phrs.2021.105750_bib52","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1152\/japplphysiol.00857.2016","article-title":"Altered nuclear dynamics in MDX myofibers","volume":"122","author":"Iyer","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.phrs.2021.105750_bib53","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1007\/s00018-015-2000-5","article-title":"Tubulin acetylation: responsible enzymes, biological functions and human diseases","volume":"72","author":"Li","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phrs.2021.105750_bib54","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1083\/jcb.109.5.2275","article-title":"Generation of a stable, posttranslationally modified microtubule array is an early event in myogenic differentiation","volume":"109","author":"Gundersen","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2021.105750_bib55","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.cell.2010.06.037","article-title":"Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation","volume":"142","author":"Conacci-Sorrell","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2021.105750_bib56","doi-asserted-by":"crossref","first-page":"30690","DOI":"10.1074\/jbc.M204930200","article-title":"Alteration of the C-terminal amino acid of tubulin specifically inhibits myogenic differentiation","volume":"277","author":"Chang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.105750_bib57","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1096\/fj.04-2303fje","article-title":"Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility","volume":"19","author":"Waltregny","year":"2005","journal-title":"Faseb"},{"key":"10.1016\/j.phrs.2021.105750_bib58","doi-asserted-by":"crossref","first-page":"C288","DOI":"10.1152\/ajpcell.00102.2014","article-title":"Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues","volume":"307","author":"Li","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821003340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821003340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:33:40Z","timestamp":1760913220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661821003340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":58,"alternative-id":["S1043661821003340"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105750","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105750","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105750"}}