{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:21:43Z","timestamp":1780521703779,"version":"3.54.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.phrs.2021.105920","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T10:31:35Z","timestamp":1633084295000},"page":"105920","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"special_numbering":"C","title":["Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through SESN2\/AMPK\/TSC2 pathway"],"prefix":"10.1016","volume":"173","author":[{"given":"Chao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2129-1447","authenticated-orcid":false,"given":"Yunlun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9455","key":"10.1016\/j.phrs.2021.105920_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2021.105920_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/547809","article-title":"Essential hypertension: an approach to its etiology and neurogenic pathophysiology","volume":"2013","author":"Bolivar","year":"2013","journal-title":"Int. J. Hypertens."},{"issue":"4","key":"10.1016\/j.phrs.2021.105920_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phrs.2021.105920_bib4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/5584_2016_90","article-title":"Endothelial dysfunction and hypertension","volume":"956","author":"Konukoglu","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/HYPERTENSIONAHA.110.166314","article-title":"Persistent macrovascular and microvascular dysfunction in patients with malignant hypertension","volume":"57","author":"Shantsila","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2021.105920_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vph.2018.12.005","article-title":"The endothelial status reflected by circulating endothelial cells, circulating endothelial progenitor cells and soluble thrombomodulin in patients with mild and resistant hypertension","volume":"113","author":"Budzyn","year":"2019","journal-title":"Vasc. Pharm."},{"issue":"2 Suppl.","key":"10.1016\/j.phrs.2021.105920_bib7","first-page":"II1S","article-title":"Reactivity of small blood vessels in hypertension: relation with structural changes. State of the art lecture","volume":"19","author":"Schiffrin","year":"1992","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.phrs.2021.105920_bib8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s11906-010-0150-2","article-title":"Vascular endothelial function and hypertension: insights and directions","volume":"12","author":"Dharmashankar","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"issue":"1","key":"10.1016\/j.phrs.2021.105920_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.109.214601","article-title":"Therapeutic targeting of mitochondrial superoxide in hypertension","volume":"107","author":"Dikalova","year":"2010","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.phrs.2021.105920_bib10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/ars.2012.4918","article-title":"Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension","volume":"20","author":"Dikalov","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phrs.2021.105920_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.vph.2019.01.004","article-title":"Angiotensin II and vascular damage in hypertension: role of oxidative stress and sympathetic activation","volume":"115","author":"Masi","year":"2019","journal-title":"Vasc. Pharm."},{"issue":"8","key":"10.1016\/j.phrs.2021.105920_bib12","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1161\/01.ATV.0000021412.56621.A2","article-title":"Vascular inflammation and the renin-angiotensin system","volume":"22","author":"Brasier","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2021.105920_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00041552-200503000-00007","article-title":"Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II","volume":"14","author":"Touyz","year":"2005","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.18388\/abp.2016_1284","article-title":"Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review","volume":"63","author":"Kiewisz","year":"2016","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.phrs.2021.105920_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/835934","article-title":"Are endothelial progenitor cells the real solution for cardiovascular diseases? Focus on controversies and perspectives","volume":"2015","author":"Balistreri","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"2","key":"10.1016\/j.phrs.2021.105920_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jash.2011.11.003","article-title":"Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells","volume":"6","author":"Burger","year":"2012","journal-title":"J. Am. Soc. Hypertens."},{"issue":"1","key":"10.1016\/j.phrs.2021.105920_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12872-020-01326-2","article-title":"Influencing factors of vascular endothelial function in patients with non-obstructive coronary atherosclerosis: a 1-year observational study","volume":"20","author":"Li","year":"2020","journal-title":"BMC Cardiovasc. Disord."},{"issue":"5","key":"10.1016\/j.phrs.2021.105920_bib18","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/jhh.2014.85","article-title":"Quantitative and functional characteristics of endothelial progenitor cells in newly diagnosed hypertensive patients","volume":"29","author":"Skrzypkowska","year":"2015","journal-title":"J. Hum. Hypertens."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/10641963.2019.1632339","article-title":"Berberine reduces endothelial injury and arterial stiffness in spontaneously hypertensive rats","volume":"42","author":"Zhang","year":"2020","journal-title":"Clin. Exp. Hypertens."},{"issue":"22","key":"10.1016\/j.phrs.2021.105920_bib20","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1042\/CS20160587","article-title":"Endothelial progenitor cells and hypertension: current concepts and future implications","volume":"130","author":"Luo","year":"2016","journal-title":"Clin. Sci."},{"issue":"12","key":"10.1016\/j.phrs.2021.105920_bib21","doi-asserted-by":"crossref","first-page":"8493","DOI":"10.1111\/jcmm.14739","article-title":"MiR-205 promotes endothelial progenitor cell angiogenesis and deep vein thrombosis recanalization and resolution by targeting PTEN to regulate Akt\/autophagy pathway and MMP2 expression","volume":"23","author":"Sun","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"4","key":"10.1016\/j.phrs.2021.105920_bib22","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib23","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"6","key":"10.1016\/j.phrs.2021.105920_bib24","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D\u2019Arcy","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.phrs.2021.105920_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-981-15-4272-5_14","article-title":"Autophagy and hypertension","volume":"1207","author":"Du","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"6","key":"10.1016\/j.phrs.2021.105920_bib26","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/HYPERTENSIONAHA.111.00469","article-title":"Redox-sensitive endoplasmic reticulum stress and autophagy at rostral ventrolateral medulla contribute to hypertension in spontaneously hypertensive rats","volume":"61","author":"Chao","year":"2013","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.phrs.2021.105920_bib27","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s00109-019-01841-6","article-title":"Autophagy plays a critical role in Klotho gene deficiency-induced arterial stiffening and hypertension","volume":"97","author":"Chen","year":"2019","journal-title":"J. Mol. Med."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib28","first-page":"1327","article-title":"Chemerin stimulates aortic smooth muscle cell proliferation and migration via activation of autophagy in VSMCs of metabolic hypertension rats","volume":"11","author":"Wen","year":"2019","journal-title":"Am. J. Transl. Res."},{"issue":"10","key":"10.1016\/j.phrs.2021.105920_bib29","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/CIRCULATIONAHA.113.002416","article-title":"Histone deacetylase inhibition blunts ischemia\/reperfusion injury by inducing cardiomyocyte autophagy","volume":"129","author":"Xie","year":"2014","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.phrs.2021.105920_bib30","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.jacc.2009.08.031","article-title":"Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction","volume":"54","author":"Buss","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phrs.2021.105920_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7687083","article-title":"Defective autophagy in atherosclerosis: to die or to senesce?","volume":"2018","author":"Grootaert","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.phrs.2021.105920_bib32","first-page":"595","article-title":"MicroRNA-199a-5p aggravates primary hypertension by damaging vascular endothelial cells through inhibition of autophagy and promotion of apoptosis","volume":"16","author":"Tian","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/aps.2017.120","article-title":"Rhynchophylla total alkaloid rescues autophagy, decreases oxidative stress and improves endothelial vasodilation in spontaneous hypertensive rats","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharm. Sin."},{"issue":"1","key":"10.1016\/j.phrs.2021.105920_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41467-017-02280-y","article-title":"LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription","volume":"9","author":"Liu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2021.105920_bib35","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.omtn.2019.06.009","article-title":"lncRNA GAS5 inhibits cell migration and invasion and promotes autophagy by targeting miR-222-3p via the GAS5\/PTEN-signaling pathway in CRC","volume":"17","author":"Liu","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"7","key":"10.1016\/j.phrs.2021.105920_bib36","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1096\/fj.201802744R","article-title":"Nrf2-lncRNA controls cell fate by modulating p53-dependent Nrf2 activation as an miRNA sponge for Plk2 and p21(cip1)","volume":"33","author":"Joo","year":"2019","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib37","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2010.06.040","article-title":"A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response","volume":"142","author":"Huarte","year":"2010","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.phrs.2021.105920_bib38","doi-asserted-by":"crossref","first-page":"6334","DOI":"10.1073\/pnas.0911082107","article-title":"P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis","volume":"107","author":"Yamakuchi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib39","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2010.07.029","article-title":"Noncoding RNAs: the missing \"linc\" in p53-mediated repression","volume":"142","author":"Barsotti","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.phrs.2021.105920_bib40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.molcel.2013.11.004","article-title":"Reciprocal regulation of HIF-1alpha and lincRNA-p21 modulates the Warburg effect","volume":"53","author":"Yang","year":"2014","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.phrs.2021.105920_bib41","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.molcel.2014.04.025","article-title":"LincRNA-p21 activates p21 in cis to promote polycomb target gene expression and to enforce the G1\/S checkpoint","volume":"54","author":"Dimitrova","year":"2014","journal-title":"Mol. Cell"},{"issue":"17","key":"10.1016\/j.phrs.2021.105920_bib42","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/CIRCULATIONAHA.114.011675","article-title":"LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity","volume":"130","author":"Wu","year":"2014","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.phrs.2021.105920_bib43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1089\/dna.2015.2966","article-title":"The role of long intergenic noncoding RNA p21 in vascular endothelial cells","volume":"34","author":"He","year":"2015","journal-title":"DNA Cell Biol."},{"issue":"6","key":"10.1016\/j.phrs.2021.105920_bib44","doi-asserted-by":"crossref","first-page":"8513","DOI":"10.3892\/mmr.2017.7623","article-title":"Long intergenic noncoding RNA p21 mediates oxidized LDL induced apoptosis and expression of LOX1 in human coronary artery endothelial cells","volume":"16","author":"Zhou","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"17","key":"10.1016\/j.phrs.2021.105920_bib45","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/CIRCULATIONAHA.114.011675","article-title":"LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity","volume":"130","author":"Wu","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2021.105920_bib46","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s12265-020-10074-9","article-title":"p53-dependent LincRNA-p21 protects against proliferation and anti-apoptosis of vascular smooth muscle cells in atherosclerosis by upregulating SIRT7 via microRNA-17-5p","volume":"14","author":"Wang","year":"2020","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.phrs.2021.105920_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.15","article-title":"LincRNA-p21 acts as a mediator of ING1b-induced apoptosis","volume":"6","author":"Tran","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phrs.2021.105920_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.67","article-title":"Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes","volume":"6","author":"Hall","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phrs.2021.105920_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104990","article-title":"Sestrin2 as a potential therapeutic target for cardiovascular diseases","volume":"159","author":"Gao","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib50","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cell.2008.06.028","article-title":"p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling","volume":"134","author":"Budanov","year":"2008","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.phrs.2021.105920_bib51","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2174\/1574888X13666180502100620","article-title":"Endothelial progenitor cells as molecular targets in vascular senescence and repair","volume":"13","author":"Rana","year":"2018","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.phrs.2021.105920_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1960804","article-title":"The use of endothelial progenitor cells for the regeneration of musculoskeletal and neural tissues","volume":"2017","author":"Kamei","year":"2017","journal-title":"Stem Cells Int."},{"issue":"1","key":"10.1016\/j.phrs.2021.105920_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4330\/wjc.v9.i1.1","article-title":"Endothelial progenitor cells: exploring the pleiotropic effects of statins","volume":"9","author":"Sandhu","year":"2017","journal-title":"World J. Cardiol."},{"issue":"1","key":"10.1016\/j.phrs.2021.105920_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190494","article-title":"Effect of intensive multifactorial treatment on vascular progenitor cells in hypertensive patients","volume":"13","author":"Maroun-Eid","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.105920_bib55","article-title":"PGC-1alpha gene transfer restores adhesion and reendothelialization of endothelial progenitor cells from patients with hypertension","author":"Xie","year":"2020","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.phrs.2021.105920_bib56","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7453161","article-title":"Angiotensin II attenuates the bioactivities of human endothelial progenitor cells via downregulation of \u03b22-adrenergic receptor","volume":"2018","author":"Lee","year":"2018","journal-title":"Stem Cells Int."},{"issue":"2","key":"10.1016\/j.phrs.2021.105920_bib57","first-page":"131","article-title":"Decreased FENDRR and LincRNA-p21 expression in atherosclerotic plaque","volume":"19","author":"Cekin","year":"2018","journal-title":"Anatol. J. Cardiol."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib58","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cmet.2008.08.010","article-title":"p53 strikes mTORC1 by employing sestrins","volume":"8","author":"Hay","year":"2008","journal-title":"Cell Metab."},{"issue":"9","key":"10.1016\/j.phrs.2021.105920_bib59","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1101\/gad.212282.112","article-title":"Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses","volume":"27","author":"Kenzelmann Broz","year":"2013","journal-title":"Genes Dev."},{"issue":"8","key":"10.1016\/j.phrs.2021.105920_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0221104","article-title":"LncRNA expression profile during autophagy and Malat1 function in macrophages","volume":"14","author":"Ma","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.105920_bib61","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.biopha.2018.02.134","article-title":"Overexpression of long non-coding RNA H19 promotes invasion and autophagy via the PI3K\/AKT\/mTOR pathways in trophoblast cells","volume":"101","author":"Xu","year":"2018","journal-title":"Biomed. Pharm."},{"issue":"10","key":"10.1016\/j.phrs.2021.105920_bib62","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1111\/jcmm.13754","article-title":"Knockdown of lncRNA AK139328 alleviates myocardial ischaemia\/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy","volume":"22","author":"Yu","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phrs.2021.105920_bib63","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3389\/fphar.2019.01617","article-title":"Rhynchophylline attenuates senescence of endothelial progenitor cells by enhancing autophagy","volume":"10","author":"Lin","year":"2019","journal-title":"Front. Pharm."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib64","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10456-016-9504-y","article-title":"Quercitrin treatment protects endothelial progenitor cells from oxidative damage via inducing autophagy through extracellular signal-regulated kinase","volume":"19","author":"Zhi","year":"2016","journal-title":"Angiogenesis"},{"issue":"1","key":"10.1016\/j.phrs.2021.105920_bib65","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/jcmm.13296","article-title":"Sitagliptin-mediated preservation of endothelial progenitor cell function via augmenting autophagy enhances ischaemic angiogenesis in diabetes","volume":"22","author":"Dai","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"3","key":"10.1016\/j.phrs.2021.105920_bib66","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1111\/jcmm.13434","article-title":"Monotropein promotes angiogenesis and inhibits oxidative stress-induced autophagy in endothelial progenitor cells to accelerate wound healing","volume":"22","author":"Wang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"6","key":"10.1016\/j.phrs.2021.105920_bib67","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1002\/stem.2005","article-title":"Icariin promotes angiogenic differentiation and prevents oxidative stress-induced autophagy in endothelial progenitor cells","volume":"33","author":"Tang","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.phrs.2021.105920_bib68","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/aji.12625","article-title":"Circulating endothelial cells, circulating endothelial progenitor cells, and von Willebrand factor in pregnancies complicated by hypertensive disorders","volume":"77","author":"Szpera-Gozdziewicz","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"issue":"7","key":"10.1016\/j.phrs.2021.105920_bib69","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/01.ATV.0000073832.49290.B5","article-title":"Endothelial progenitor cells: mobilization, differentiation, and homing","volume":"23","author":"Hristov","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5302","key":"10.1016\/j.phrs.2021.105920_bib70","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.phrs.2021.105920_bib71","doi-asserted-by":"crossref","first-page":"94783","DOI":"10.1371\/journal.pone.0094783","article-title":"Co-transplantation of endothelial progenitor cells and pancreatic islets to induce long-lasting normoglycemia in streptozotocin-treated diabetic rats","volume":"9","author":"Quaranta","year":"2014","journal-title":"PLoS One"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821005041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821005041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T01:49:41Z","timestamp":1734400181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661821005041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":71,"alternative-id":["S1043661821005041"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105920","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through SESN2\/AMPK\/TSC2 pathway","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2021.105920","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105920"}}