{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:57:49Z","timestamp":1789826269481,"version":"4.0.1"},"reference-count":314,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.phrs.2021.106025","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T20:05:48Z","timestamp":1638821148000},"page":"106025","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Modulatory role of the endocannabinoidome in the pathophysiology of the gastrointestinal tract"],"prefix":"10.1016","volume":"175","author":[{"given":"Jerome","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Casari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Falasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2021.106025_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/S1516-44462006000200015","article-title":"History of cannabis as a medicine: a review","volume":"28","author":"Zuardi","year":"2006","journal-title":"Braz. J. Psychiatry"},{"key":"10.1016\/j.phrs.2021.106025_bib2","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1021\/ja01062a046","article-title":"Isolation, structure, and partial synthesis of an active constituent of Hashish","volume":"86","author":"Gaoni","year":"1964","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phrs.2021.106025_bib3","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/0040-4020(63)85022-X","article-title":"The structure of cannabidiol","volume":"19","author":"Mechoulam","year":"1963","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phrs.2021.106025_bib4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/346561a0","article-title":"Structure of a cannabinoid receptor and functional expression of the cloned cDNA","volume":"346","author":"Matsuda","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"Munro","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib6","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.phrs.2021.106025_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","article-title":"Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors","volume":"50","author":"Mechoulam","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/bbrc.1995.2437","article-title":"2-arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain","volume":"215","author":"Sugiura","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2021.106025_bib9","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/j.pain.2013.03.023","article-title":"Endocannabinoids: a unique opportunity to develop multitarget analgesics","volume":"154","author":"Maione","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2021.106025_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/164_2016_105","article-title":"Cannabinoid receptors in regulating the GI tract: experimental evidence and therapeutic relevance","volume":"239","author":"Taschler","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tips.2015.02.008","article-title":"Endocannabinoid signaling at the periphery: 50 years after THC","volume":"36","author":"Maccarrone","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.plipres.2016.02.002","article-title":"Endocannabinoids and endocannabinoid-related mediators: targets, metabolism and role in neurological disorders","volume":"62","author":"Iannotti","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.phrs.2021.106025_bib13","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s13311-015-0374-6","article-title":"The endocannabinoid system and its modulation by phytocannabinoids","volume":"12","author":"Di Marzo","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.phrs.2021.106025_bib14","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-nutr-043020-090216","article-title":"Roles of endocannabinoids and endocannabinoid-like molecules in energy homeostasis and metabolic regulation: a nutritional perspective","author":"Rahman","year":"2021","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.phrs.2021.106025_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105729","article-title":"The endocannabinoidome in neuropsychiatry: opportunities and potential risks","volume":"170","author":"Morris","year":"2021","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phrs.2021.106025_bib16","first-page":"694","article-title":"Lysophosphatidylinositol signalling: new wine from an old bottle","volume":"2012","author":"Pi\u00f1eiro","year":"1821","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2021.106025_bib17","doi-asserted-by":"crossref","first-page":"27849","DOI":"10.1074\/jbc.M404087200","article-title":"Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha)","volume":"279","author":"Guzm\u00e1n","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2006.02.004","article-title":"Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents","volume":"3","author":"Overton","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib19","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s00018-004-4494-0","article-title":"Regulation of food intake by oleoylethanolamide","volume":"62","author":"Lo Verme","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib20","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.tem.2013.03.001","article-title":"A fatty gut feeling","volume":"24","author":"Piomelli","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib21","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2021.106025_bib22","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1053\/j.gastro.2016.04.015","article-title":"The role of the endocannabinoid system in the brain \u2013 gut axis","volume":"151","author":"Sharkey","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2021.106025_bib23","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/0026-0495(90)90168-C","article-title":"Impaired glucose tolerance and diabetes in obesity: a 6-year follow-up study of glucose metabolism","volume":"39","author":"Jallut","year":"1990","journal-title":"Metabolism"},{"key":"10.1016\/j.phrs.2021.106025_bib24","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/sj.ijo.0800678","article-title":"The metabolic effects of preferential reduction of visceral adipose tissue in abdominally obese men","volume":"22","author":"Marks","year":"1998","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phrs.2021.106025_bib25","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.diabres.2010.04.012","article-title":"The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of propective cohort studies","volume":"89","author":"Abdullah","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.phrs.2021.106025_bib27","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phrs.2021.106025_bib28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/cne.10270","article-title":"Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus","volume":"448","author":"Coutts","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phrs.2021.106025_bib29","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.2337\/db06-0263","article-title":"Adipose tissue: from lipid storage compartment to endocrine organ","volume":"55","author":"Scherer","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2021.106025_bib30","doi-asserted-by":"crossref","first-page":"30817","DOI":"10.1074\/jbc.M402367200","article-title":"Insulin\/Foxo1 pathway regulates expression levels of adiponectic receptors and adiponectic sensitivity","volume":"279","author":"Tsuchida","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature12198","article-title":"Gut metagenome in European women with normal, impaired and diabetic glucose control","volume":"498","author":"Karlsson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009085","article-title":"Gut microbiota in human adults with type 2 diabetes differes from non-diabetic adults","volume":"5","author":"Larsen","year":"2010","journal-title":"PLos ONE"},{"key":"10.1016\/j.phrs.2021.106025_bib33","doi-asserted-by":"crossref","first-page":"G78","DOI":"10.1152\/ajpgi.90285.2008","article-title":"Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats","volume":"295","author":"Duncan","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.phrs.2021.106025_bib34","doi-asserted-by":"crossref","DOI":"10.5376\/gab.2016.07.0003","article-title":"Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults","author":"Kaliyappan","year":"2016","journal-title":"Genom. Appl. Biol."},{"key":"10.1016\/j.phrs.2021.106025_bib35","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4049\/jimmunol.179.1.514","article-title":"NOD1\/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells","volume":"179","author":"Park","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2021.106025_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/432785","article-title":"Collaborative action of toll-like and nod-like receptors as modulators of the inflammatory response to pathogenic bacteria","author":"Oviedo-Boyso","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phrs.2021.106025_bib37","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/pr.110.003004","article-title":"International union of basic and clinical pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB\u2081 and CB\u2082","volume":"62","author":"Pertwee","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phrs.2021.106025_bib38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jmgm.2012.10.005","article-title":"A homology modeling study toward the understanding of three-dimensional structure and putative pharmacological profiule of the G-protein coupled receptor GPR55","volume":"39","author":"Orgil Elbegdorj","year":"2013","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.phrs.2021.106025_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2014.06.007","article-title":"GPR55: from orphan to metabolic regulator?","volume":"145","author":"Liu","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2021.106025_bib40","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2174\/1570159X14666160729155441","article-title":"Advances in the physiology of GPR55 in the central nervous system","volume":"15","author":"Marichal-Cancino","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib41","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1096\/fj.201800171R","article-title":"GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues","volume":"33","author":"Lipina","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.phrs.2021.106025_bib42","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/bph.12356","article-title":"Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice","volume":"170","author":"McKillop","year":"2013","journal-title":"Br. J. Pharmcol."},{"key":"10.1016\/j.phrs.2021.106025_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179504","article-title":"The role of the \u03b1 cell in the pathogenesis of diabetes: a world beyond the mirror","volume":"22","author":"Mart\u00ednez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib44","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0167-4889(88)90013-4","article-title":"Mobilization of cellular Ca2+ by lysophospholipids in rat islets of Langerhans","volume":"968","author":"Metz","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2021.106025_bib45","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1476-5381.2010.00744.x","article-title":"GPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells","volume":"161","author":"Bondarenko","year":"2010","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2021.106025_bib46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/dom.13062","article-title":"Therapeutic application of GPR119 ligands in metabolic disorders","volume":"20","author":"Yang","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib47","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1365-2982.2008.01248.x","article-title":"The identification of peroxisome proliferator-activated receptor alpha-independent effects of oleoylethanolamide on intestinal transit in mice","volume":"4","author":"Cluny","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.phrs.2021.106025_bib48","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.bbalip.2018.06.007","article-title":"Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR-119","volume":"1863","author":"Arifin","year":"2018","journal-title":"Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.phrs.2021.106025_bib49","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1111\/bph.12746","article-title":"Activation of GPR18 by cannabinoid compounds: a tale of biased agonism","volume":"171","author":"Console-Bram","year":"2014","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2021.106025_bib50","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1111\/j.1476-5381.2011.01497.x","article-title":"\u0394(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells","volume":"165","author":"McHugh","year":"2012","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2021.106025_bib51","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/mnfr.201500449","article-title":"G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction","volume":"60","author":"Rajaraman","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phrs.2021.106025_bib52","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.bbrc.2006.06.175","article-title":"Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18","volume":"347","author":"Kohno","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2021.106025_bib53","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1073\/pnas.0510676103","article-title":"N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties","volume":"103","author":"Milman","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2021.106025_bib54","doi-asserted-by":"crossref","first-page":"842","DOI":"10.4049\/jimmunol.1601650","article-title":"Novel resolvin D2 receptor axis in infectious inflammation","volume":"198","author":"Chiang","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2021.106025_bib55","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2091-10-14","article-title":"The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways","volume":"10","author":"Bradshaw","year":"2009","journal-title":"BMC Biochem."},{"key":"10.1016\/j.phrs.2021.106025_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ph14030270","article-title":"Effects of GPR18 ligands on body weight and metabolic parameters in a female rat model of excessive eating","author":"Kota\u0144ska","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.phrs.2021.106025_bib57","doi-asserted-by":"crossref","first-page":"14216","DOI":"10.1021\/acs.jmedchem.0c00926","article-title":"Therapeutic exploitation of GPR18: beyond the cannabinoids?","volume":"63","author":"Morales","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib58","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1084\/jem.20150225","article-title":"Identification of resolvin D2 receptor mediating resolution of infections and organ protection","volume":"212","author":"Chiang","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2021.106025_bib59","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1755-148X.2010.00781.x","article-title":"Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target","volume":"24","author":"Qin","year":"2011","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.phrs.2021.106025_bib60","doi-asserted-by":"crossref","first-page":"32255","DOI":"10.1038\/srep32255","article-title":"Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18","volume":"6","author":"Flegel","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2021.106025_bib61","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2202-11-44","article-title":"N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor","volume":"11","author":"McHugh","year":"2010","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.phrs.2021.106025_bib62","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1021\/acsptsci.9b00075","article-title":"New advances in targeting the resolution of inflammation: implications for specialized pro-resolving mediator GPCR drug discovery","volume":"3","author":"Park","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib63","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13041-018-0351-1","article-title":"Resolvin D2 protects against cerebral ischemia\/reperfusion injury in rats","volume":"11","author":"Zuo","year":"2018","journal-title":"Mol. Brain"},{"key":"10.1016\/j.phrs.2021.106025_bib64","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.nutres.2008.08.003","article-title":"Endocannabinoids, metabolic regulation, and the role of diet","volume":"28","author":"Carr","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.phrs.2021.106025_bib65","doi-asserted-by":"crossref","first-page":"42639","DOI":"10.1074\/jbc.M107351200","article-title":"Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain","volume":"276","author":"Huang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib66","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3389\/fendo.2018.00420","article-title":"Involvement of TRPV1 channels in energy homeostasis","volume":"9","author":"Christie","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phrs.2021.106025_bib67","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.neuron.2012.12.016","article-title":"TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids","volume":"77","author":"Cao","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2021.106025_bib68","doi-asserted-by":"crossref","first-page":"G130","DOI":"10.1152\/ajpgi.00388.2007","article-title":"Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice","volume":"294","author":"Bielefeldt","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.phrs.2021.106025_bib69","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1161\/01.RES.0000262653.84850.8b","article-title":"Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity","volume":"100","author":"Zhang","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2021.106025_bib70","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1111\/j.1432-1033.2004.04081.x","article-title":"Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels","volume":"271","author":"Van Der Stelt","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.phrs.2021.106025_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/nu11081956","article-title":"Lifestyle and metabolic syndrome: contribution of the endocannabinoidome","volume":"11","author":"Di Marzo","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2021.106025_bib72","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/35050121","article-title":"Induction of vanilloid receptor channel activity by protein kinase C","volume":"408","author":"Premkumar","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib73","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1469-7793.2001.00813.x","article-title":"Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide","volume":"534","author":"Vellani","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.phrs.2021.106025_bib74","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1556\/APhysiol.97.2010.2.1","article-title":"The endogenous cannabinoid anandamide inhibits transient receptor potential vanilloid type 1 receptor-mediated currents in rat cultured primary sensory neurons","volume":"97","author":"S\u00e1ntha","year":"2010","journal-title":"Acta Physiol. Hung."},{"key":"10.1016\/j.phrs.2021.106025_bib75","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1096\/fj.14-268300","article-title":"Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance","volume":"29","author":"Lee","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.phrs.2021.106025_bib76","doi-asserted-by":"crossref","first-page":"450","DOI":"10.18632\/aging.100306","article-title":"Hyperactive when young, hypoactive and overweight when aged: connecting the dots in the story about locomotor activity, body mass, and aging in Trpv1 knockout mice","volume":"3","author":"Wanner","year":"2011","journal-title":"Aging"},{"key":"10.1016\/j.phrs.2021.106025_bib77","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.appet.2014.02.018","article-title":"Capsaicin increases sensation of fullness in energy balance, and decreases desire to eat after dinner in negative energy balance","volume":"77","author":"Janssens","year":"2014","journal-title":"Appetite"},{"key":"10.1016\/j.phrs.2021.106025_bib78","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3945\/jn.112.170613","article-title":"Addition of capsaicin and exchange of carbohydrate with protein counteract energy intake restriction effects on fullness and energy expenditure","volume":"143","author":"Smeets","year":"2013","journal-title":"J. Nutr."},{"key":"10.1016\/j.phrs.2021.106025_bib79","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067786","article-title":"Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance","volume":"8","author":"Janssens","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.106025_bib80","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.foodqual.2010.04.003","article-title":"Effects of hot spices on energy intake, appetite and sensory specific desires in humans","volume":"21","author":"Reinbach","year":"2010","journal-title":"Food Qual. Pref."},{"key":"10.1016\/j.phrs.2021.106025_bib81","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00394-009-0006-1","article-title":"The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety","volume":"48","author":"Smeets","year":"2009","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.phrs.2021.106025_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135892","article-title":"TRPV1 channels and gastric vagal afferent signalling in lean and high fat diet induced obese mice","volume":"10","author":"Kentish","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.106025_bib83","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1734-1140(13)71055-7","article-title":"Expression of multiple transient receptor potential channel genes in murine 3T3-L1 cell lines and adipose tissue","volume":"65","author":"Bishnoi","year":"2013","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.phrs.2021.106025_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103093","article-title":"Capsaicin induces \"brite\" phenotype in differentiating 3T3-L1 preadipocytes","volume":"9","author":"Baboota","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.106025_bib85","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1111\/bph.13514","article-title":"Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms","volume":"173","author":"Baskaran","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib86","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/ijo.2017.16","article-title":"TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue","volume":"41","author":"Baskaran","year":"2017","journal-title":"Int J. Obes."},{"key":"10.1016\/j.phrs.2021.106025_bib87","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1460-9568.2006.05261.x","article-title":"Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes","volume":"25","author":"Gram","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2021.106025_bib88","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.cell.2006.10.038","article-title":"TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes","volume":"127","author":"Razavi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2021.106025_bib89","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00232-014-9658-8","article-title":"Role for the TRPV1 channel in insulin secretion from pancreatic beta cells","volume":"247","author":"Diaz-Garcia","year":"2014","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.phrs.2021.106025_bib90","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1021\/acs.jafc.7b00132","article-title":"Capsaicin reduces blood glucose by increasing insulin levels and glycogen content better than capsiate in streptozotocin-induced diabetic rats","volume":"65","author":"Zhang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib91","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1017\/S0007114515003104","article-title":"The metabolic effects of a commercially available chicken peri-peri (African bird\u2019s eye chilli) meal in overweight individuals","volume":"117","author":"Kroff","year":"2017","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phrs.2021.106025_bib92","first-page":"915","article-title":"Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators","volume":"2007","author":"Zoete","year":"1771","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2021.106025_bib93","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3389\/fphar.2020.00730","article-title":"Peroxisome proliferator-activated receptors: experimental targeting for the treatment of inflammatory bowel diseases","volume":"11","author":"Decara","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib94","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031001","article-title":"Relevance of peroxisome proliferator activated receptors in multitarget paradigm associated with the endocannabinoid system","volume":"22","author":"Lago-Fernandez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib95","first-page":"200","article-title":"Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine","volume":"2008","author":"Artmann","year":"1781","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2021.106025_bib96","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature01921","article-title":"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha","volume":"425","author":"Fu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib97","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.lfs.2005.05.012","article-title":"The search for the palmitoylethanolamide receptor","volume":"77","author":"LoVerme","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib98","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/sj.bjp.0707478","article-title":"Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism","volume":"152","author":"Sun","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib99","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1124\/mol.105.019117","article-title":"Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2","volume":"70","author":"Rockwell","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib100","doi-asserted-by":"crossref","first-page":"12748","DOI":"10.1074\/jbc.M114.559062","article-title":"Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor \u03b2\/\u03b4 (PPAR\u03b2\/\u03b4) in the brain","volume":"289","author":"Yu","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib101","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1476-511X-11-51","article-title":"Oleamide activates peroxisome proliferator-activated receptor gamma (PPAR\u03b3) in vitro","volume":"11","author":"Dionisi","year":"2012","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.phrs.2021.106025_bib102","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molmet.2014.02.002","article-title":"Integrated physiology and systems biology of PPAR\u03b1","volume":"3","author":"Kersten","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib103","doi-asserted-by":"crossref","first-page":"27307","DOI":"10.1074\/jbc.272.43.27307","article-title":"Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice","volume":"272","author":"Peters","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib104","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/MCB.15.6.3012","article-title":"Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators","volume":"15","author":"Lee","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2021.106025_bib105","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.phrs.2009.01.018","article-title":"PPAR-alpha modulate the anti-inflammatory effect of glucocorticoids in the secondary damage in experimental spinal cord trauma","volume":"59","author":"Genovese","year":"2009","journal-title":"Pharmacol. Res"},{"key":"10.1016\/j.phrs.2021.106025_bib106","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6661642","article-title":"PPAR\u03b1 agonist WY-14643 relieves neuropathic pain through SIRT1-mediated deacetylation of NF-\u03baB","volume":"2020","author":"Wen","year":"2020","journal-title":"PPAR Res."},{"key":"10.1016\/j.phrs.2021.106025_bib107","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/328797","article-title":"Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism","volume":"2013","author":"Di Cesare Mannelli","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phrs.2021.106025_bib108","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.biochem.77.061307.091829","article-title":"Fat and beyond: the diverse biology of PPARgamma","volume":"77","author":"Tontonoz","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.phrs.2021.106025_bib109","doi-asserted-by":"crossref","first-page":"34268","DOI":"10.1074\/jbc.M300043200","article-title":"Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass","volume":"278","author":"Gavrilova","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib110","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1073\/pnas.0403652101","article-title":"Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity","volume":"101","author":"Zhang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2021.106025_bib111","doi-asserted-by":"crossref","first-page":"R345","DOI":"10.1152\/ajpregu.00545.2002","article-title":"Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice","volume":"284","author":"Ravinet Trillou","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.phrs.2021.106025_bib112","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(05)66374-X","article-title":"Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study","volume":"365","author":"Van Gaal","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2021.106025_bib113","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.pbb.2010.03.012","article-title":"The endocannabinoid system, eating behavior and energy homeostasis: the end or a new beginning?","volume":"95","author":"Bermudez-Silva","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2021.106025_bib114","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fendo.2020.00114","article-title":"Phytocannabinoids: useful drugs for the treatment of obesity? special focus on cannabidiol","volume":"11","author":"Bielawiec","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phrs.2021.106025_bib115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.sjpain.2012.08.004","article-title":"Evaluation of the analgesic efficacy of AZD1940, a novel cannabinoid agonist, on post-operative pain after lower third molar surgical removal","volume":"4","author":"Kalliom\u00e4ki","year":"2013","journal-title":"Scand. J. Pain."},{"key":"10.1016\/j.phrs.2021.106025_bib116","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/AJP.0b013e318219799a","article-title":"A randomized, controlled study to investigate the analgesic efficacy of single doses of the cannabinoid receptor-2 agonist GW842166, ibuprofen or placebo in patients with acute pain following third molar tooth extraction","volume":"27","author":"Ostenfeld","year":"2011","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.phrs.2021.106025_bib117","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2010.11.002","article-title":"Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury","volume":"50","author":"Mukhopadhyay","year":"2011","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.phrs.2021.106025_bib118","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1161\/ATVBAHA.112.300275","article-title":"Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice","volume":"33","author":"Lenglet","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.phrs.2021.106025_bib119","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1476-5381.2010.00908.x","article-title":"A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents","volume":"161","author":"Cluny","year":"2010","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2021.106025_bib120","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2012.07.002","article-title":"Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance","volume":"16","author":"Tam","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib121","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.molmet.2016.10.004","article-title":"Targeting the endocannabinoid\/CB1 receptor system for treating obesity in Prader-Willi syndrome","volume":"5","author":"Knani","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib122","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nm1521","article-title":"Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors","volume":"13","author":"Rousseaux","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2021.106025_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105135","article-title":"Targeting gut barrier dysfunction with phytotherapies: effective strategy against chronic diseases","volume":"161","author":"Dey","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2021.106025_bib124","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1073\/pnas.1612177114","article-title":"Endocannabinoid system acts as a regulator of immune homeostasis in the gut","volume":"114","author":"Acharya","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2021.106025_bib125","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1440-1746.2012.07108.x","article-title":"Oxidative stress in inflammation-based gastrointestinal tract diseases: challenges and opportunities","volume":"27","author":"Kim","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2021.106025_bib126","doi-asserted-by":"crossref","unstructured":"Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation, Antioxidants & Redox Signaling, 29, 2018, 75\u2013108.","DOI":"10.1089\/ars.2017.7144"},{"key":"10.1016\/j.phrs.2021.106025_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105822","article-title":"Pharmacological and structure-activity relationship studies of oleoyl-lysophosphatidylinositol synthetic mimetics","volume":"172","author":"Paternoster","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phrs.2021.106025_bib128","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjp.0707460","article-title":"The orphan receptor GPR55 is a novel cannabinoid receptor","volume":"152","author":"Ryberg","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib129","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1073\/pnas.0711278105","article-title":"GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current","volume":"105","author":"Lauckner","year":"2008","journal-title":"PNAS"},{"key":"10.1016\/j.phrs.2021.106025_bib130","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/sj.bjp.0707419","article-title":"The novel endocannabinoid receptor GRP55 is activated by atypical cannabinoids but does not mediate their vasodilator effects","volume":"152","author":"Johns","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib131","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1476-5381.2009.00625.x","article-title":"GPR55 ligands promote receptor coupling to multiple signalling pathways","volume":"160","author":"Henstridge","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib132","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/dom.13180","article-title":"LH-21 and abnormal cannabidiol improve B-cell function in isolated human and mouse islets through GPR55-dependent and -independent signalling","volume":"20","author":"Ruz-Maldonado","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib133","first-page":"1132","article-title":"Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119","volume":"2018","author":"Arifin","year":"1863","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.phrs.2021.106025_bib134","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.tips.2012.03.014","article-title":"GPR119 as a fat sensor","volume":"33","author":"Hansen","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib135","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/01635581.2013.795599","article-title":"Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer","volume":"65","author":"Slattery","year":"2013","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.phrs.2021.106025_bib136","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biochi.2004.10.018","article-title":"The role of MAPKs in adipocyte differentiation and obesity","volume":"87","author":"Bost","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.phrs.2021.106025_bib137","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bbrc.2012.01.027","article-title":"N-arachidonoyl glycine induces macrophage apoptosis via GPR18","volume":"418","author":"Takenouchi","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2021.106025_bib138","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133854","article-title":"GPR18 controls reconstitution of mouse small intestine intraepithelial lymphocytes following bone marrow transplantation","volume":"10","author":"Becker","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.106025_bib139","doi-asserted-by":"crossref","first-page":"623.621","DOI":"10.1096\/fasebj.29.1_supplement.623.1","article-title":"Endocannabinoid GPR18 receptor activation confers cardiovascular protection in diabetic rats","volume":"29","author":"Ahmed","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.phrs.2021.106025_bib140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-016-0777-2","article-title":"Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity","volume":"14","author":"Pascoal","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2021.106025_bib141","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/bs.acc.2015.06.005","article-title":"Peroxisome proliferator-activated receptor \u03b1 in lipid metabolism and atherosclerosis","volume":"71","author":"Yu","year":"2015","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib142","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/B978-0-12-800101-1.00007-7","article-title":"The roles of peroxisome proliferator-activated receptors in the metabolic syndrome","volume":"121","author":"Mansour","year":"2014","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib143","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/305347","article-title":"The PPAR \u03b1 \/ \u03b3 agonist, tesaglitazar, improves insulin mediated switching of tissue glucose and free fatty acid utilization in vivo in the obese zucker rat","volume":"2013","author":"Wallenius","year":"2013","journal-title":"PPAR Res."},{"key":"10.1016\/j.phrs.2021.106025_bib144","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1475-2840-4-14","article-title":"Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons","volume":"4","author":"Tenenbaum","year":"2005","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.phrs.2021.106025_bib145","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1517\/14728222.2011.581231","article-title":"Targeting the peroxisome proliferator-activated receptors (PPARs) in spinal cord injury","volume":"15","author":"Esposito","year":"2011","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.phrs.2021.106025_bib146","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.neuropharm.2012.05.013","article-title":"WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-\u03b3 pathway","volume":"63","author":"Fakhfouri","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2021.106025_bib147","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/ptr.5095","article-title":"Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP+ cells through PPAR\u03b3 involvement","volume":"28","author":"Scuderi","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phrs.2021.106025_bib148","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1111\/bph.13497","article-title":"An update on PPAR activation by cannabinoids","volume":"173","author":"O\u2019Sullivan","year":"2016","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2021.106025_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101087","article-title":"Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53\/miRNA-22\/SIRT1\/PPAR\u03b1 dependent","volume":"42","author":"Azar","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib150","first-page":"313","article-title":"Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes","volume":"2005","author":"Luquet","year":"1740","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2021.106025_bib151","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s10875-010-9386-5","article-title":"Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome","volume":"30","author":"Miao","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.phrs.2021.106025_bib152","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-38865-4","article-title":"Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer","volume":"9","author":"Grill","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2021.106025_bib153","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/can.2016.0001","article-title":"Endocannabinoids in the gut","volume":"1","author":"DiPatrizio","year":"2016","journal-title":"Cannabis Cannabinoid Res."},{"key":"10.1016\/j.phrs.2021.106025_bib154","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0014-2999(99)00673-1","article-title":"The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats","volume":"384","author":"Izzo","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0014-2999(99)00165-X","article-title":"Delta9-tetrahydrocannabinol inhibits gastric motility in the rat through cannabinoid CB1 receptors","volume":"371","author":"Krowicki","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib156","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s10620-006-3130-2","article-title":"Effects of cannabinoid receptor agonists on rat gastric acid secretion: discrepancy between in vitro and in vivo data","volume":"51","author":"Coruzzi","year":"2006","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib157","first-page":"9","article-title":"Antimicrobial activity of Cannabis sativa extracts on Lancefield group a Streptococcus species associated with streptococcal pharyngitis (Strep throat) African","volume":"2","author":"Anumudu","year":"2020","journal-title":"J. Biol. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib158","doi-asserted-by":"crossref","DOI":"10.1186\/s42238-020-0016-7","article-title":"Delta9-tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes","volume":"2","author":"Abioye","year":"2020","journal-title":"J. Cannabis Res."},{"key":"10.1016\/j.phrs.2021.106025_bib159","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/bph.12944","article-title":"Are cannabidiol and delta9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? a systematic review","volume":"172","author":"McPartland","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.isci.2020.101504","article-title":"Activation of cannabinoid receptor 2 prevents colitis-associated colon cancer through myeloid cell de-activation upstream of IL-22 production","volume":"23","author":"Becker","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.phrs.2021.106025_bib161","doi-asserted-by":"crossref","first-page":"131","DOI":"10.18632\/oncoscience.119","article-title":"Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival","volume":"2","author":"Martinez-Martinez","year":"2015","journal-title":"Oncoscience"},{"key":"10.1016\/j.phrs.2021.106025_bib162","doi-asserted-by":"crossref","DOI":"10.3390\/cells10010071","article-title":"Linking the endocannabinoidome with specific metabolic parameters in an overweight and insulin-resistant population: from multivariate exploratory analysis to univariate analysis and construction of predictive models","volume":"10","author":"Depommier","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2021.106025_bib163","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051554","article-title":"Obesity affects the microbiota-gut-brain axis and the regulation thereof by endocannabinoids and related mediators","volume":"21","author":"Forte","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib164","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/10408690091189248","article-title":"Energy density of foods: effects on energy intake","volume":"40","author":"Stubbs","year":"2000","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phrs.2021.106025_bib165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0014-2999(01)00953-0","article-title":"Critical role of the endogenous cannabinoid system in mouse pup suckling and growth","volume":"419","author":"Fride","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib166","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1203\/PDR.0b013e3181559d42","article-title":"Inhibition of milk ingestion and growth after administration of a neutral cannabinoid CB1 receptor antagonist on the first postnatal day in the mouse","volume":"62","author":"Fride","year":"2007","journal-title":"Pedia Res."},{"key":"10.1016\/j.phrs.2021.106025_bib167","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.2337\/db06-0812","article-title":"Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity","volume":"55","author":"Bl\u00fcher","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2021.106025_bib168","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.drudis.2018.01.029","article-title":"Peripheral modulation of the endocannabinoid system in metabolic disease","volume":"23","author":"Shrestha","year":"2018","journal-title":"Drug Disco Today"},{"key":"10.1016\/j.phrs.2021.106025_bib169","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/bph.13226","article-title":"Role of the endocannabinoid system in diabetes and diabetic complications","volume":"173","author":"Gruden","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib170","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/sj.ijo.0803539","article-title":"Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men","volume":"31","author":"C\u00f4t\u00e9","year":"2007","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phrs.2021.106025_bib171","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00125-008-1178-6","article-title":"Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors","volume":"52","author":"Di Marzo","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2021.106025_bib172","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0091-6773(75)91684-3","article-title":"Cannabis: effects on hunger and thirst","volume":"15","author":"Abel","year":"1975","journal-title":"Behav. Biol."},{"key":"10.1016\/j.phrs.2021.106025_bib173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0195-6663(88)80017-5","article-title":"Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory","volume":"11","author":"Foltin","year":"1988","journal-title":"Appetite"},{"key":"10.1016\/j.phrs.2021.106025_bib174","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nn.2494","article-title":"Bimodal control of stimulated food intake by the endocannabinoid system","volume":"13","author":"Bellocchio","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2021.106025_bib175","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1365-2036.1999.00441.x","article-title":"Delta-9-tetrahydrocannabinol delays the gastric emptying of solid food in humans: a double-blind, randomized study","volume":"13","author":"McCallum","year":"1999","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2021.106025_bib176","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.coph.2012.09.009","article-title":"A potential role for GPR55 in gastrointestinal functions","volume":"12","author":"Schicho","year":"2012","journal-title":"Curr. Opin. Pharm."},{"key":"10.1016\/j.phrs.2021.106025_bib177","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.beem.2008.10.003","article-title":"Role of acylethanolamides in the gastrointestinal tract with special reference to food intake and energy balance","volume":"23","author":"Borrelli","year":"2009","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib178","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jnutbio.2009.07.006","article-title":"Analysis of gene expression pattern reveals potential targets of dietary oleoylethanolamide in reducing body fat gain in C3H mice","volume":"21","author":"Thabuis","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phrs.2021.106025_bib179","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1073\/pnas.0711278105","article-title":"GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current","volume":"105","author":"Lauckner","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2021.106025_bib180","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1530\/JOE-11-0166","article-title":"A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans","volume":"211","author":"Romero-Zerbo","year":"2011","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.phrs.2021.106025_bib181","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/dom.13180","article-title":"LH-21 and abnormal cannabidiol improve \u03b2-cell function in isolated human and mouse islets through GPR55-dependent and -independent signalling","volume":"20","author":"Ruz-Maldonado","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib182","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/ijo.2015.209","article-title":"Deletion of G-protein-coupled receptor 55 promotes obesity by reducing physical activity","volume":"40","author":"Meadows","year":"2016","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phrs.2021.106025_bib183","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167965","article-title":"Deletion of Gpr55 results in subtle effects on energy metabolism, motor activity and thermal pain sensation","volume":"11","author":"Bjursell","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2021.106025_bib184","article-title":"The endocannabinoid system in the adipose organ","author":"Jung","year":"2021","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.phrs.2021.106025_bib185","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nn1457","article-title":"Endocannabinoid control of food intake and energy balance","volume":"8","author":"Di Marzo","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2021.106025_bib186","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2010.02.015","article-title":"CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance","volume":"11","author":"Quarta","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib187","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cmet.2012.01.021","article-title":"2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism","volume":"15","author":"Jung","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib188","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/372686a0","article-title":"Formation and inactivation of endogenous cannabinoid anandamide in central neurons","volume":"372","author":"Di Marzo","year":"1994","journal-title":"Nature"},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2021.106025_bib189","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1365-2826.2008.01682.x","article-title":"Cannabinoid type 1 receptor: another arrow in the adipocytes\u2019 bow","volume":"20","author":"Bellocchio","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.phrs.2021.106025_bib190","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1210\/jc.2007-0768","article-title":"The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms","volume":"92","author":"Pagano","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib191","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.tem.2018.03.001","article-title":"Regulation of adipose tissue metabolism by the endocannabinoid system","volume":"29","author":"van Eenige","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib192","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.2337\/db09-1881","article-title":"Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways","volume":"59","author":"Tedesco","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2021.106025_bib193","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113447","article-title":"PGC-1\u03b1 as a pivotal factor in lipid and metabolic regulation","volume":"19","author":"Cheng","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib194","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1463-1326.2009.01133.x","article-title":"Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes","volume":"12","author":"Perwitz","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib195","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1172\/JCI83626","article-title":"Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages","volume":"127","author":"Ruiz de Azua","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.phrs.2021.106025_bib196","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2741\/s156","article-title":"Physiological importance and control of non-shivering facultative thermogenesis","volume":"3","author":"Silva","year":"2011","journal-title":"Front. Biosci."},{"key":"10.1016\/j.phrs.2021.106025_bib197","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/npp.2011.19","article-title":"The cannabinoid receptor agonist THC attenuates weight loss in a rodent model of activity-based anorexia","volume":"36","author":"Verty","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2021.106025_bib198","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrm1592","article-title":"The mitochondrial uncoupling-protein homologues","volume":"6","author":"Krauss","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2021.106025_bib199","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1096\/fj.13-247643","article-title":"Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity","volume":"28","author":"Boon","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.phrs.2021.106025_bib200","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1136\/gutjnl-2018-316723","article-title":"Human gut microbiome: hopes, threats and promises","volume":"67","author":"Cani","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2021.106025_bib201","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1136\/gutjnl-2014-306928","article-title":"Microbiota and diabetes: an evolving relationship","volume":"63","author":"Tilg","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.phrs.2021.106025_bib202","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-4939-0897-4_14","article-title":"Microbiota, inflammation and obesity","volume":"817","author":"Sanz","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phrs.2021.106025_bib203","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrendo.2015.211","article-title":"Endocannabinoids--at the crossroads between the gut microbiota and host metabolism","volume":"12","author":"Cani","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.phrs.2021.106025_bib204","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.cell.2020.09.022","article-title":"Endocannabinoids inhibit the induction of virulence in enteric pathogens","volume":"183","author":"Ellermann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2021.106025_bib205","article-title":"Exploring the endocannabinoidome in genetically obese (ob\/ob) and diabetic (db\/db) mice: links with inflammation and gut microbiota","author":"Suriano","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.phrs.2021.106025_bib206","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091246","article-title":"Oral capsaicinoid administration alters the plasma endocannabinoidome and fecal microbiota of reproductive-aged women living with overweight and obesity","volume":"9","author":"Manca","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.phrs.2021.106025_bib207","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.phrs.2021.106025_bib208","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2217\/fmb.11.142","article-title":"The relationship between gut microbiota and weight gain in humans","volume":"7","author":"Angelakis","year":"2012","journal-title":"Future Microbiol."},{"key":"10.1016\/j.phrs.2021.106025_bib209","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2021.106025_bib210","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4161\/gmic.19625","article-title":"Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity","volume":"3","author":"Cani","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phrs.2021.106025_bib211","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib212","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib213","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib214","first-page":"1","article-title":"The gut microbiome profile in obesity: a systematic review","author":"Castaner","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.phrs.2021.106025_bib215","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/ijo.2011.153","article-title":"Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii","volume":"36","author":"Million","year":"2011","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phrs.2021.106025_bib216","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3945\/ajcn.110.010132","article-title":"Energy-balance studies reveal associations between gut microbes, caloric load and nutrient absorption in humans","volume":"94","author":"Jumpertz","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phrs.2021.106025_bib217","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1016\/j.febslet.2014.09.039","article-title":"Meta-analyses of human gut microbes associated with obesity and IBD","volume":"588","author":"Walters","year":"2017","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phrs.2021.106025_bib218","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01995-17","article-title":"Looking for a signal in the noise: revisiting obesity and the microbiome","volume":"8","author":"Sze","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.phrs.2021.106025_bib219","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature23874","article-title":"Commensal bacteria product GPCR ligands that mimic human signalling molecules","volume":"549","author":"Cohen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib220","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1210\/edrv-16-3-390","article-title":"Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide","volume":"16","author":"Fehmann","year":"1995","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phrs.2021.106025_bib221","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2337\/diabetes.51.2007.S434","article-title":"The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion","volume":"51","author":"Patrick","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2021.106025_bib222","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/endo.142.2.7983","article-title":"Minireview: the glucagon-like peptides","volume":"142","author":"Drucker","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2021.106025_bib223","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3389\/fendo.2018.00584","article-title":"Dissecting the physiology and pathophysiology of glucagon-like peptide-1","volume":"9","author":"Paternoster","year":"2018","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.phrs.2021.106025_bib224","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3727\/105221618X15156018385515","article-title":"Bile acid metabolism in liver pathobiology","volume":"18","author":"Chiang","year":"2018","journal-title":"Gene Expr."},{"key":"10.1016\/j.phrs.2021.106025_bib225","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jobm.3630220505","article-title":"Microbial transformation of bile acids. a unified scheme for bile acid degradation and hydroxylation of bile acids","volume":"22","author":"Hayakawa","year":"2007","journal-title":"Zeit . Allg. Mikrobiolgie"},{"key":"10.1016\/j.phrs.2021.106025_bib226","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/01.sla.0000133117.12646.48","article-title":"The early effect of the roux-en-y gastric bypass on hormones involved in body weight regulation and glucose metabolism","volume":"240","author":"Rubino","year":"2004","journal-title":"Ann. Surg."},{"key":"10.1016\/j.phrs.2021.106025_bib227","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.phrs.2009.03.019","article-title":"Endocannabinoids and immune regulation","volume":"60","author":"Pandey","year":"2009","journal-title":"Pharm. Res"},{"key":"10.1016\/j.phrs.2021.106025_bib228","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21238929","article-title":"The immune endocannabinoid system of the tumor microenvironment","volume":"21","author":"Kienzl","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib229","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0014-5793(98)00275-0","article-title":"The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines","volume":"425","author":"Derocq","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phrs.2021.106025_bib230","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3181\/00379727-180-42195","article-title":"Effects of acute and subchronic delta 9-tetrahydrocannabinol administration on the plasma catecholamine, beta-endorphin, and corticosterone levels and splenic natural killer cell activity in rats","volume":"180","author":"Patel","year":"1985","journal-title":"Proc. Soc. Exp. Biol. Med"},{"key":"10.1016\/j.phrs.2021.106025_bib231","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/15287398709530986","article-title":"Inhibition of natural killer cell function by marijuana components","volume":"20","author":"Klein","year":"1987","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.phrs.2021.106025_bib232","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.lfs.2004.02.007","article-title":"Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide","volume":"75","author":"Kraft","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib233","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nri2778","article-title":"Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria","volume":"10","author":"Varol","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2021.106025_bib234","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/mi.2011.50","article-title":"Oral ingestion of Capsaicin, the pungent component of chili pepper, enhances a discreet population of macrophages and confers protection from autoimmune diabetes","volume":"5","author":"Nevius","year":"2012","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.phrs.2021.106025_bib235","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00418-018-1719-0","article-title":"Cellular localization and regulation of receptors and enzymes of the endocannabinoid system in intestinal and systemic inflammation","volume":"151","author":"Grill","year":"2019","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.phrs.2021.106025_bib236","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","article-title":"Inflammatory bowel disease","volume":"28","author":"Kaser","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.phrs.2021.106025_bib237","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2021.106025_bib238","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2021.07.042","article-title":"Extraintestinal manifestations of inflammatory bowel disease: current concepts, treatment, and implications for disease management","author":"Rogler","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2021.106025_bib239","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41577-019-0268-7","article-title":"Host-microbiota interactions in inflammatory bowel disease","volume":"20","author":"Caruso","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2021.106025_bib240","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib241","doi-asserted-by":"crossref","DOI":"10.3390\/nu11071532","article-title":"Dietary approach-a way forward to manage nutrient deficiency, effects of the western diet, and food intolerances in inflammatory bowel disease","volume":"11","author":"Laing","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2021.106025_bib242","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/17474124.2017.1292851","article-title":"Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?","volume":"11","author":"Hasenoehrl","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2021.106025_bib243","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000120","article-title":"Cannabinoids and opioids in the treatment of inflammatory bowel diseases","volume":"11","author":"Kienzl","year":"2020","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.phrs.2021.106025_bib244","article-title":"Cannabis for the treatment of Crohn\u2019s disease","volume":"11","author":"Kafil","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.phrs.2021.106025_bib245","article-title":"Cannabis for the treatment of ulcerative colitis","volume":"11","author":"Kafil","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.phrs.2021.106025_bib246","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cgh.2013.04.034","article-title":"Cannabis induces a clinical response in patients with Crohn\u2019s disease: a prospective placebo-controlled study","volume":"11","author":"Naftali","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phrs.2021.106025_bib247","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI200419465","article-title":"The endogenous cannabinoid system protects against colonic inflammation","volume":"113","author":"Massa","year":"2004","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.phrs.2021.106025_bib248","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.plipres.2011.01.001","article-title":"Is lipid signaling through cannabinoid 2 receptors part of a protective system?","volume":"50","author":"Pacher","year":"2011","journal-title":"Prog. Lipid Res"},{"key":"10.1016\/j.phrs.2021.106025_bib249","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.gastro.2005.05.026","article-title":"Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing","volume":"129","author":"Wright","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2021.106025_bib250","first-page":"639","article-title":"No association between the functional cannabinoid receptor type 2 Q63R variants and inflammatory bowel disease in Turkish subjects","volume":"25","author":"Yonal","year":"2014","journal-title":"Turk. J. Gastroenterol."},{"key":"10.1016\/j.phrs.2021.106025_bib251","article-title":"Safety, pharmacokinetics, and efficacy of olorinab, a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, in a phase 2a study of patients with chronic abdominal pain associated with Crohn\u2019s disease","volume":"3","author":"Yacyshyn","year":"2020","journal-title":"Crohn\u2019s Colitis"},{"key":"10.1016\/j.phrs.2021.106025_bib252","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000332079","article-title":"Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study","volume":"85","author":"Lahat","year":"2012","journal-title":"Digestion"},{"key":"10.1016\/j.phrs.2021.106025_bib253","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1080\/00365521.2017.1298834","article-title":"G protein-coupled receptor 55 (GPR55) expresses differently in patients with Crohn\u2019s disease and ulcerative colitis","volume":"52","author":"W\u0142odarczyk","year":"2017","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.phrs.2021.106025_bib254","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/bph.12907","article-title":"Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent","volume":"172","author":"Borrelli","year":"2015","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2021.106025_bib255","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/ibd.21538","article-title":"The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment","volume":"17","author":"Schicho","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.phrs.2021.106025_bib256","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/MPA.0b013e318259f6f0","article-title":"Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice","volume":"42","author":"Li","year":"2013","journal-title":"Pancreas"},{"key":"10.1016\/j.phrs.2021.106025_bib257","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1176\/appi.ajp.2017.17040413","article-title":"Cannabis use and risk of prescription opioid use disorder in the United States","volume":"175","author":"Olfson","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2021.106025_bib258","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.tins.2012.04.006","article-title":"THe thrifty lipids: endocannabinoids and the neural control of energy conservation","volume":"35","author":"DiPatrizio","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2021.106025_bib259","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1476-5381.2009.00183.x","article-title":"Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding","volume":"158","author":"Izzo","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib260","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.yebeh.2016.09.040","article-title":"Cannabis and epilepsy: an ancient treasure returns to the fore","volume":"70","author":"Russo","year":"2017","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.phrs.2021.106025_bib261","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ibror.2019.07.1138","article-title":"Subtyping austism: can we predict treatment response in Autism Spectrum Disorder?","volume":"6","author":"Eapen","year":"2019","journal-title":"IBRO Rep."},{"key":"10.1016\/j.phrs.2021.106025_bib262","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/sj.ijo.0802583","article-title":"CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity","volume":"28","author":"Ravinet Trillou","year":"2004","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phrs.2021.106025_bib263","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/j.1476-5381.2008.00107.x","article-title":"Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice","volume":"156","author":"Riedel","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib264","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.2337\/dc16-0650","article-title":"Efficacy and safety of cannabidiol and tetrahydrocannabivarin on glycemic and lipid parameters in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel group pilot study","volume":"39","author":"Jadoon","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phrs.2021.106025_bib265","first-page":"180","article-title":"Medicinal Cannabis: history, pharmacology and implications for the acute care setting","volume":"42","author":"Bridgeman","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phrs.2021.106025_bib266","article-title":"Medicinal cannabis: history, pharmacology and implicationsl","volume":"3","author":"Wargent","year":"2013","journal-title":"Nutr. Diabet."},{"key":"10.1016\/j.phrs.2021.106025_bib267","doi-asserted-by":"crossref","DOI":"10.3390\/metabo6010006","article-title":"Lysophosphatidylinositol signalling and metabolic diseases","volume":"6","author":"Arifin","year":"2016","journal-title":"Metabolites"},{"key":"10.1016\/j.phrs.2021.106025_bib268","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2337\/db11-0649","article-title":"The L-\u03b1-lysophosphatidylinositol\/GPR55 system and its potential role in human obesity","volume":"61","author":"Moreno-Navarrete","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2021.106025_bib269","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41586-019-1797-8","article-title":"The integrative biology of type 2 diabetes","volume":"576","author":"Roden","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib270","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jpainsymman.2017.09.001","article-title":"Results of a double-blind, randomized, placebo-controlled study of nabiximols oromucosal spray as an adjunctive therapy in advanced. cancer patients with chronic uncontrolled pain","volume":"55","author":"Aron","year":"2018","journal-title":"J. Pain. Symptom Manag."},{"key":"10.1016\/j.phrs.2021.106025_bib271","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/156720512799015064","article-title":"Metabolic dysfunction in Alzheimer\u2019s disease and related neurodegenerative disorders","volume":"9","author":"Huan Cai","year":"2012","journal-title":"Curr. Alzheimer Res"},{"key":"10.1016\/j.phrs.2021.106025_bib272","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1212\/WNL.53.9.1937","article-title":"Diabetes mellitus and the risk of dementia: The Rotterdam Study","volume":"53","author":"Ott A","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2021.106025_bib273","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3390\/ijms16010378","article-title":"Oxidative stress in obesity: a criticial component in human diseases","volume":"16","author":"Lucia Marseglia","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib274","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1210\/er.2005-0009","article-title":"The endocannabinoid system in endocrine regulation and energy balance","volume":"27","author":"M.G. Pagotto","year":"2006","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phrs.2021.106025_bib275","article-title":"Cannabinoids, opoids and eating behaviour: the molecular face of hedonism?","volume":"51","author":"M.G. Bellocchio","year":"2006","journal-title":"Bran Res. Rev."},{"key":"10.1016\/j.phrs.2021.106025_bib276","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbior.2019.100672","article-title":"Abilities of \u03b2-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells","volume":"75","author":"Akula","year":"2020","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.phrs.2021.106025_bib277","article-title":"profile and functional characterization of AVE1625, a novel cannabinoid CB1 receptor antaganoist","author":"Diu-Hercent","year":"2005","journal-title":"Soc. Neurosci."},{"key":"10.1016\/j.phrs.2021.106025_bib278","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.2337\/dc16-0650","article-title":"Efficacy and safety of cannabidiol and tetrahydrocannabivarin on glycemic and lipid parameters in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel group pilot study","volume":"39","author":"Khalid","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phrs.2021.106025_bib279","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1056\/NEJMsr1606602","article-title":"Body fatness and cancer - viewpoint of the IARC working group","volume":"375","author":"Lauby-Secretan","year":"2016","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.phrs.2021.106025_bib280","article-title":"The intricate relationship between diabetes, obesity and pancreatic cancer","volume":"2020","author":"Paternoster","year":"1873","journal-title":"Biochim Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.phrs.2021.106025_bib281","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cell.2004.09.005","article-title":"At the crossroads of inflammationa and cancer","volume":"118","author":"Clevers","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2021.106025_bib282","article-title":"Does dietary fat affect inflammatory markers in overweight and obese individuals?- a review of randomized controlled trials from 2010-2016","volume":"12","author":"Telle-Hensen","year":"2017","journal-title":"Genes Nutr."},{"key":"10.1016\/j.phrs.2021.106025_bib283","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cmet.2015.03.001","article-title":"Regulation of obesity-related insulin resistance with gut anti-inflammatory agents","volume":"21","author":"Luck","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2021.106025_bib284","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/431405a","article-title":"Cancer: an inflammatory link","volume":"431","author":"Balkwill","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib285","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.07.013","article-title":"Inflammation and tumorigenesis in a mouse model of colitis-associated cancer","volume":"118","author":"Greten","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2021.106025_bib286","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02924","article-title":"NF-kappaB functions as a tumour promoter in inflammation-associated cancer","volume":"431","author":"Pikarsky","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2021.106025_bib287","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2019.00339","article-title":"The endocannabinoid system as a target in cancer diseases: are we there yet?","volume":"10","author":"Moreno","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib288","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nrc3247","article-title":"Towards the use of cannabinoids as antitumour agents","volume":"12","author":"Velasco","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phrs.2021.106025_bib289","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1158\/0008-5472.CAN-05-4566","article-title":"Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation","volume":"66","author":"Caffarel","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.phrs.2021.106025_bib290","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1517\/14728222.2011.553606","article-title":"Update on the endocannabinoid system as an anticancer target.","volume":"15","author":"Malfitano","year":"2011","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.phrs.2021.106025_bib291","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nrc3247","article-title":"Towards the use of cannabinoids as antitumour agents","volume":"12","author":"Velasco","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phrs.2021.106025_bib292","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/978-3-319-20825-1_16","article-title":"Endocannabinoids and Cancer","author":"Velasco","year":"2015","journal-title":"Handb. Exp. Pharmacol. Endocannab."},{"key":"10.1016\/j.phrs.2021.106025_bib293","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113275","article-title":"The interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment","volume":"12","author":"Moreno","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.phrs.2021.106025_bib294","unstructured":"U. DATABASE, UALCAN DATABASE. Available online, 2020."},{"key":"10.1016\/j.phrs.2021.106025_bib295","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1038\/s41388-018-0390-1","article-title":"GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine","volume":"37","author":"Ferro","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.phrs.2021.106025_bib296","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jneumeth.2011.05.021","article-title":"Production of functional recombinant G-protein coupled receptors for heteromerization studies","volume":"199","author":"Cavic","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.phrs.2021.106025_bib297","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.1471-4159.2010.06810.x","article-title":"Gi protein coupling to adenosine A1-A2A receptor heteromers in human brain caudate nucleus","volume":"114","author":"Casado","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2021.106025_bib298","doi-asserted-by":"crossref","first-page":"21960","DOI":"10.1074\/jbc.M114.561761","article-title":"Targeting CB2-GPR55 receptor heteromers modulates cancer cell signalling","volume":"289","author":"Moreno","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2021.106025_bib299","first-page":"9991","article-title":"Simultaneous activation of induced heterodimerization between CXCR4 chemokine receptor and cannabinoid receptor 2 (CB2) reveals a mechanism for regulation of tumor progression","volume":"291","author":"Coke","year":"2016","journal-title":"J. Biochem."},{"key":"10.1016\/j.phrs.2021.106025_bib300","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1158\/1541-7786.MCR-16-0481","article-title":"Agonist-induced CXCR4 and CB2heterodimerizationinhibits Galpha13\/RhoA-mediated migration","volume":"16","author":"Scarlett","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.phrs.2021.106025_bib301","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1046\/j.1472-8206.2002.00094.x","article-title":"Effect on cancer cell profileration of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems","volume":"16","author":"de Petrocellis","year":"2002","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib302","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/ijc.23114","article-title":"Cannabinoids in pancreatic cancer: correlation with survival and pain","volume":"122","author":"O.F. Michalski","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.phrs.2021.106025_bib303","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1158\/0008-5472.CAN-06-0169","article-title":"Cannabinoids induce apoptosis in pancreatic tumor cells via endoplasmic reticulum stress-related genes","volume":"66","author":"G.M. Carracedo","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.phrs.2021.106025_bib304","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.febslet.2006.02.024","article-title":"Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism","volume":"580","author":"Stefano Fogli","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phrs.2021.106025_bib305","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fphar.2019.00430","article-title":"Modulation of the endocannabinoid system as a potential anticancer strategy","volume":"10","author":"Robert Ramer","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib306","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11481-015-9608-y","article-title":"The antitumor activity of plant-derived non-psychoactive cannabinoids","volume":"10","author":"McAllister","year":"2015","journal-title":"J. Neuroimm. Pharmacol."},{"key":"10.1016\/j.phrs.2021.106025_bib307","first-page":"301","article-title":"Critical appraisal of the potential use of cannabinoids in cancer management","volume":"5","author":"Cridge","year":"2013","journal-title":"Cancer Manag. Res"},{"key":"10.1016\/j.phrs.2021.106025_bib308","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1158\/0008-5472.CAN-03-3720","article-title":"Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE\/ADAM17)-mediated transactivation of the epidermal growth factor receptor","volume":"64","author":"Hart","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.phrs.2021.106025_bib309","doi-asserted-by":"crossref","first-page":"14","DOI":"10.17305\/bjbms.2018.3532","article-title":"Cannabinoids in cancer treatment: Therapeutic potential and legislation","volume":"19","author":"Barbara Daris","year":"2019","journal-title":"Bosn. J. Basic Med Sci."},{"key":"10.1016\/j.phrs.2021.106025_bib310","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.18632\/oncotarget.1723","article-title":"FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EFG\/EFGR pathway","volume":"5","author":"Ravi","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.phrs.2021.106025_bib311","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4103\/0976-500X.189661","article-title":"What failed BIA 10-2474 phase I clinical trail? Global speculations and recommendations for future Phase I trials","volume":"7","author":"Kaur","year":"2016","journal-title":"J. Pharm. Pharmacother."},{"key":"10.1016\/j.phrs.2021.106025_bib312","unstructured":"W. Q, The price of mistakes in clinical trials NY: The Rockerfeller University, 2012."},{"key":"10.1016\/j.phrs.2021.106025_bib313","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1021\/acs.molpharmaceut.8b01344","article-title":"Cannabidiol enhances the passage of lipid nanocapsules across the blood-brain barrier both in vitro and in vivo","volume":"16","author":"Juan Aparicio-Blanco","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2021.106025_bib314","doi-asserted-by":"crossref","first-page":"69","DOI":"10.7150\/jca.36588","article-title":"Recent advances of drug delivery nanocarriers in osteosarcoma treatment","volume":"11","author":"Shang-Yu Wang","year":"2020","journal-title":"J. Cancer"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821006095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661821006095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:32:34Z","timestamp":1760913154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661821006095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":314,"alternative-id":["S1043661821006095"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2021.106025","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulatory role of the endocannabinoidome in the pathophysiology of the gastrointestinal tract","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2021.106025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106025"}}