{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:08:49Z","timestamp":1793765329083,"version":"4.6.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","award":["2021fckbc06"],"award-info":[{"award-number":["2021fckbc06"]}],"id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901493"],"award-info":[{"award-number":["81901493"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801469"],"award-info":[{"award-number":["81801469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.phrs.2022.106127","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T21:30:04Z","timestamp":1644442204000},"page":"106127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2\/PPAR\u03b3\/sFlt-1 axis in preeclampsia"],"prefix":"10.1016","volume":"177","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rencheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuening","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weirong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5728","key":"10.1016\/j.phrs.2022.106127_bib1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"issue":"9461","key":"10.1016\/j.phrs.2022.106127_bib2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"issue":"10297","key":"10.1016\/j.phrs.2022.106127_bib3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","article-title":"Pre-eclampsia","volume":"398","author":"Chappell","year":"2021","journal-title":"Lancet"},{"issue":"14","key":"10.1016\/j.phrs.2022.106127_bib4","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Preeclampsia-pathophysiology and clinical presentations: JACC state-of-the-art review","volume":"76","author":"Ives","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phrs.2022.106127_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","article-title":"Pathogenesis of preeclampsia","volume":"5","author":"Young","year":"2010","journal-title":"Annu. Rev. Pathol."},{"issue":"5","key":"10.1016\/j.phrs.2022.106127_bib6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.phrs.2022.106127_bib7","doi-asserted-by":"crossref","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.phrs.2022.106127_bib8","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrneph.2014.102","article-title":"Pre-eclampsia part 1: current understanding of its pathophysiology","volume":"10","author":"Chaiworapongsa","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"issue":"9","key":"10.1016\/j.phrs.2022.106127_bib9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrneph.2014.103","article-title":"Pre-eclampsia part 2: prediction, prevention and management","volume":"10","author":"Chaiworapongsa","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"issue":"10","key":"10.1016\/j.phrs.2022.106127_bib10","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1177\/0271678X17738701","article-title":"A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury","volume":"38","author":"Chandran","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"5","key":"10.1016\/j.phrs.2022.106127_bib11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.aanat.2014.04.002","article-title":"A possible protective role of Nrf2 in preeclampsia","volume":"196","author":"Kweider","year":"2014","journal-title":"Ann. Anat."},{"key":"10.1016\/j.phrs.2022.106127_bib12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.freeradbiomed.2020.12.441","article-title":"Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK\/Nrf2 signaling pathway in preeclampsia","volume":"164","author":"Wang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.phrs.2022.106127_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/HYPERTENSIONAHA.116.08408","article-title":"Proton pump inhibitors decrease soluble fms-like tyrosine kinase-1 and soluble endoglin secretion, decrease hypertension, and rescue endothelial dysfunction","volume":"69","author":"Onda","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2022.106127_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8839394","article-title":"1-O-hexyl-2,3,5-trimethylhydroquinone ameliorates the development of preeclampsia through suppression of oxidative stress and endothelial cell apoptosis","volume":"2021","author":"Jiang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.phrs.2022.106127_bib15","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/STROKEAHA.109.576942","article-title":"PPAR{gamma} activation prevents hypertensive remodeling of cerebral arteries and improves vascular function in female rats","volume":"41","author":"Cipolla","year":"2010","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.phrs.2022.106127_bib16","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1161\/01.ATV.19.3.546","article-title":"PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease","volume":"19","author":"Marx","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"10","key":"10.1016\/j.phrs.2022.106127_bib17","first-page":"3874","article-title":"Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner","volume":"85","author":"Schaiff","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2022.106127_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.588516","article-title":"The protective effects of peroxisome proliferator-activated receptor gamma in cerebral ischemia-reperfusion injury","volume":"11","author":"Ding","year":"2020","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1210\/en.2013-1350","article-title":"Reduced expression of 11\u03b2-hydroxysteroid dehydrogenase type 2 in preeclamptic placentas is associated with decreased PPAR\u03b3 but increased PPAR\u03b1 expression","volume":"155","author":"He","year":"2014","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.phrs.2022.106127_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.419","article-title":"ANGPTL4 mediates the protective role of PPAR\u03b3 activators in the pathogenesis of preeclampsia","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.phrs.2022.106127_bib21","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1161\/HYPERTENSIONAHA.111.179440","article-title":"Evidence implicating peroxisome proliferator-activated receptor-\u03b3 in the pathogenesis of preeclampsia","volume":"58","author":"McCarthy","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2022.106127_bib22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12916-014-0176-4","article-title":"Preventing pre-eclampsia - are dietary factors the key?","volume":"12","author":"Dodd","year":"2014","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib23","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bbrc.2006.04.085","article-title":"Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells","volume":"345","author":"Zhang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2022.106127_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101728","article-title":"Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPAR\u03b4-Dependent mechanism","volume":"37","author":"Nie","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2022.106127_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.freeradbiomed.2018.08.024","article-title":"Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state","volume":"126","author":"Su","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phrs.2022.106127_bib26","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.freeradbiomed.2016.10.491","article-title":"Molecular hydrogen ameliorates several characteristics of preeclampsia in the reduced uterine perfusion pressure (RUPP) rat model","volume":"101","author":"Ushida","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.phrs.2022.106127_bib27","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/HYPERTENSIONAHA.117.10681","article-title":"AT1-AA (angiotensin II type 1 receptor agonistic autoantibody) blockade prevents preeclamptic symptoms in placental ischemic rats","volume":"71","author":"Cunningham MW","year":"2018","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.phrs.2022.106127_bib28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1161\/HYPERTENSIONAHA.119.13929","article-title":"L-(+)-Ergothioneine significantly improves the clinical characteristics of preeclampsia in the reduced uterine perfusion pressure rat model","volume":"75","author":"Williamson","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2022.106127_bib29","first-page":"383","article-title":"Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia","volume":"122","author":"Granger","year":"2006","journal-title":"Methods Mol. Med."},{"issue":"6","key":"10.1016\/j.phrs.2022.106127_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.placenta.2004.10.002","article-title":"Human placental explants in culture: approaches and assessments","volume":"26","author":"Miller","year":"2005","journal-title":"Placenta"},{"issue":"14","key":"10.1016\/j.phrs.2022.106127_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147464","article-title":"Placental villous explant culture 2.0: flow culture allows studies closer to the in vivo situation","volume":"22","author":"Kupper","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.phrs.2022.106127_bib32","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1038\/s41596-020-0381-x","article-title":"Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta","volume":"15","author":"Sheridan","year":"2020","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib33","first-page":"1","article-title":"Gestational hypertension and preeclampsia","volume":"133","author":"ACOG Practice Bulletin No. 202","year":"2019","journal-title":"Obstet. Gynecol."},{"issue":"9","key":"10.1016\/j.phrs.2022.106127_bib34","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.placenta.2014.06.374","article-title":"Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells","volume":"35","author":"Brownfoot","year":"2014","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.phrs.2022.106127_bib35","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/HYPERTENSIONAHA.114.04781","article-title":"Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2\/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia","volume":"65","author":"Onda","year":"2015","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.phrs.2022.106127_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.phrs.2011.11.007","article-title":"Loperamide, an antidiarrhea drug, has antitumor activity by inducing cell apoptosis","volume":"65","author":"Gong","year":"2012","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.phrs.2022.106127_bib37","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41419-021-03682-z","article-title":"HIF-1\u03b1 promoted vasculogenic mimicry formation in lung adenocarcinoma through NRP1 upregulation in the hypoxic tumor microenvironment","volume":"12","author":"Fu","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.phrs.2022.106127_bib38","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.HYP.37.4.1191","article-title":"Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide","volume":"37","author":"Alexander","year":"2001","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.phrs.2022.106127_bib39","doi-asserted-by":"crossref","first-page":"H541","DOI":"10.1152\/ajpheart.01113.2007","article-title":"Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction","volume":"294","author":"Gilbert","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7","key":"10.1016\/j.phrs.2022.106127_bib40","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCULATIONAHA.111.054361","article-title":"Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia","volume":"125","author":"Rana","year":"2012","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.phrs.2022.106127_bib41","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.0000147365.86159.f5","article-title":"Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia","volume":"95","author":"Ahmad","year":"2004","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.phrs.2022.106127_bib42","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.ajog.2004.03.043","article-title":"Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. Young investigator award","volume":"190","author":"Chaiworapongsa","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.phrs.2022.106127_bib43","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/HYPERTENSIONAHA.110.164079","article-title":"Expression of placental FLT1 transcript variants relates to both gestational hypertensive disease and fetal growth","volume":"58","author":"Jebbink","year":"2011","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.phrs.2022.106127_bib45","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1161\/CIRCRESAHA.108.171504","article-title":"A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia","volume":"102","author":"Sela","year":"2008","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.phrs.2022.106127_bib46","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating antiangiogenic factors in preeclampsia","volume":"355","author":"Levine","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.phrs.2022.106127_bib47","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.phrs.2022.106127_bib48","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1161\/HYPERTENSIONAHA.119.13348","article-title":"Soluble endoglin as a marker for preeclampsia, its severity, and the occurrence of adverse outcomes","volume":"74","author":"Lea\u00f1os-Miranda","year":"2019","journal-title":"Hypertension"},{"issue":"Suppl A","key":"10.1016\/j.phrs.2022.106127_bib49","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.placenta.2008.11.009","article-title":"The two stage model of preeclampsia: variations on the theme","volume":"30","author":"Roberts","year":"2009","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/HYPERTENSIONAHA.119.13101","article-title":"Endothelial PPAR\u03b3 (peroxisome proliferator-activated receptor-\u03b3) protects from angiotensin ii-induced endothelial dysfunction in adult offspring born from pregnancies complicated by hypertension","volume":"74","author":"Nair","year":"2019","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/01.RES.0000254703.11154.18","article-title":"Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy","volume":"100","author":"Zhou","year":"2007","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/jmf.12.1.19.27","article-title":"Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia","volume":"12","author":"Chaiworapongsa","year":"2002","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0301-2115(96)02647-4","article-title":"Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia","volume":"71","author":"Austgulen","year":"1997","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.phrs.2022.106127_bib54","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/164_2020_381","article-title":"Perspectives on the clinical development of NRF2-targeting drugs","volume":"264","author":"Lastra","year":"2021","journal-title":"Handb. Exp. Pharm."},{"issue":"2","key":"10.1016\/j.phrs.2022.106127_bib55","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1165\/rcmb.2006-0340TR","article-title":"How many transcription factors does it take to turn on the heme oxygenase-1 gene?","volume":"36","author":"Alam","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","article-title":"NRF2 and the hallmarks of cancer","volume":"34","author":"Rojo de la Vega","year":"2018","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.phrs.2022.106127_bib57","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.pharmthera.2005.08.007","article-title":"Peroxisome proliferator-activated receptors and inflammation","volume":"110","author":"Moraes","year":"2006","journal-title":"Pharm. Ther."},{"issue":"3","key":"10.1016\/j.phrs.2022.106127_bib58","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/HYPERTENSIONAHA.115.05445","article-title":"Effects of pravastatin on human placenta, endothelium, and women with severe preeclampsia","volume":"66","author":"Brownfoot","year":"2015","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.phrs.2022.106127_bib59","doi-asserted-by":"crossref","first-page":"356.e1","DOI":"10.1016\/j.ajog.2015.12.019","article-title":"Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction","volume":"214","author":"Brownfoot","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.phrs.2022.106127_bib60","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ebiom.2019.02.013","article-title":"Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction","volume":"41","author":"Brownfoot","year":"2019","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.phrs.2022.106127_bib61","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jnutbio.2015.03.003","article-title":"Grape seed procyanidins administered at physiological doses to rats during pregnancy and lactation promote lipid oxidation and up-regulate AMPK in the muscle of male offspring in adulthood","volume":"26","author":"Crescenti","year":"2015","journal-title":"J. Nutr. Biochem."},{"issue":"13","key":"10.1016\/j.phrs.2022.106127_bib62","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1161\/CIRCULATIONAHA.106.660134","article-title":"Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1","volume":"115","author":"Cudmore","year":"2007","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.phrs.2022.106127_bib63","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00418-020-01892-8","article-title":"AT-rich interactive domain 1A protein expression in normal and pathological pregnancies complicated by preeclampsia","volume":"154","author":"Fantone","year":"2020","journal-title":"Histochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106127_bib64","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/HYPERTENSIONAHA.121.17267","article-title":"Induction of the PPAR\u03b3 (peroxisome proliferator-activated receptor \u03b3)-GCM1 (glial cell missing 1) syncytialization axis reduces sFLT1 (soluble fms-like tyrosine kinase 1) in the preeclamptic placenta","volume":"78","author":"Armistead","year":"2021","journal-title":"Hypertension"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182200072X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366182200072X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:22:04Z","timestamp":1777605724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366182200072X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":64,"alternative-id":["S104366182200072X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106127","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2\/PPAR\u03b3\/sFlt-1 axis in preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106127"}}