{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:28:02Z","timestamp":1777494482361,"version":"3.51.4"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.phrs.2022.106226","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T18:58:41Z","timestamp":1650481121000},"page":"106226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of mice"],"prefix":"10.1016","volume":"179","author":[{"given":"Yeonggwang","family":"Hwang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung-Chun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Joo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2022.106226_bib1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1200\/JCO.2011.36.1360","article-title":"Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors","volume":"30","author":"Bendell","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phrs.2022.106226_bib2","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2217\/fon.15.56","article-title":"Buparlisib in breast cancer","volume":"11","author":"Sirohi","year":"2015","journal-title":"Future Oncol."},{"key":"10.1016\/j.phrs.2022.106226_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.apsb.2016.07.006","article-title":"Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy","volume":"7","author":"Zhao","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phrs.2022.106226_bib4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/14740338.2019.1623877","article-title":"Benefits versus risk profile of buparlisib for the treatment of breast cancer","volume":"18","author":"Patsouris","year":"2019","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.phrs.2022.106226_bib5","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1200\/JCO.18.01207","article-title":"Buparlisib in patients with recurrent glioblastoma harboring phosphatidylinositol 3-kinase pathway activation: an open-label, multicenter, multi-arm, phase II trial","volume":"37","author":"Wen","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phrs.2022.106226_bib6","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41416-020-01074-2","article-title":"Mouse-human co-clinical trials demonstrate superior anti-tumour effects of buparlisib (BKM120) and cetuximab combination in squamous cell carcinoma of head and neck","volume":"123","author":"Kim","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.phrs.2022.106226_bib7","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1200\/JCO.2013.54.0518","article-title":"Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive\/human epidermal growth factor receptor 2-negative metastatic breast cancer","volume":"32","author":"Mayer","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phrs.2022.106226_bib8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2017.02.030","article-title":"Phase II trial of the PI3 kinase inhibitor buparlisib (BKM-120) with or without enzalutamide in men with metastatic castration resistant prostate cancer","volume":"81","author":"Armstrong","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.phrs.2022.106226_bib9","first-page":"821","article-title":"PI3K inhibitors: understanding toxicity mechanisms and management","volume":"31","author":"Greenwell","year":"2017","journal-title":"Oncology"},{"key":"10.1016\/j.phrs.2022.106226_bib10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.stem.2018.03.015","article-title":"Human hippocampal neurogenesis persists throughout aging","volume":"22","author":"Boldrini","year":"2018","journal-title":"Cell. Stem Cell."},{"key":"10.1016\/j.phrs.2022.106226_bib11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nature25975","article-title":"Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults","volume":"555","author":"Sorrells","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2022.106226_bib12","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1038\/npp.2009.75","article-title":"Antidepressants increase neural progenitor cells in the human hippocampus","volume":"34","author":"Boldrini","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2022.106226_bib13","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.neuropharm.2010.01.012","article-title":"Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients","volume":"58","author":"Lucassen","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2022.106226_bib14","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1038\/sj.npp.1301041","article-title":"Hippocampal cytogenesis correlates to escitalopram-mediated recovery in a chronic mild stress rat model of depression","volume":"31","author":"Jayatissa","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2022.106226_bib15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression","volume":"62","author":"David","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2022.106226_bib16","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1248\/bpb.32.1776","article-title":"The function of Notch1 signaling was increased in parallel with neurogenesis in rat hippocampus after chronic fluoxetine administration","volume":"32","author":"Sui","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phrs.2022.106226_bib17","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/mp.2009.15","article-title":"Adult hippocampal neurogenesis is involved in anxiety-related behaviors","volume":"14","author":"Revest","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2022.106226_bib18","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nature10287","article-title":"Adult hippocampal neurogenesis buffers stress responses and depressive behaviour","volume":"476","author":"Snyder","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2022.106226_bib19","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1038\/npp.2015.85","article-title":"Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors","volume":"40","author":"Hill","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2022.106226_bib20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fnana.2015.00074","article-title":"Increased doublecortin (DCX) expression and incidence of DCX-immunoreactive multipolar cells in the subventricular zone-olfactory bulb system of suicides","volume":"9","author":"Maheu","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.phrs.2022.106226_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.620379","article-title":"Intrinsic mechanisms regulating neuronal migration in the postnatal brain","volume":"14","author":"Bressan","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib22","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/jnc.14002","article-title":"Mechanisms of neuronal migration in the adult brain","volume":"141","author":"Kaneko","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2022.106226_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fnmol.2017.00199","article-title":"Distinct features of doublecortin as a marker of neuronal migration and its implications in cancer cell mobility","volume":"10","author":"Ayanlaja","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nn1704","article-title":"Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain","volume":"9","author":"Koizumi","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mcn.2006.06.014","article-title":"Doublecortin is necessary for the migration of adult subventricular zone cells from neurospheres","volume":"33","author":"Ocbina","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib26","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/dneu.20833","article-title":"JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration","volume":"70","author":"Jin","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106226_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0896-6273(03)00843-2","article-title":"Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons","volume":"41","author":"Schaar","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2022.106226_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060272","article-title":"Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus","volume":"6","author":"Jessberger","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phrs.2022.106226_bib29","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/dneu.20850","article-title":"The role of Rho GTPase proteins in CNS neuronal migration","volume":"71","author":"Govek","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106226_bib30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fnsyn.2013.00004","article-title":"Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases","volume":"5","author":"Vadodaria","year":"2013","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29062-w","article-title":"Buparlisib is a brain penetrable pan-PI3K inhibitor","volume":"8","author":"de Gooijer","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106226_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11060-016-2158-1","article-title":"Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats","volume":"129","author":"Netland","year":"2016","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.phrs.2022.106226_bib33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbr.2012.10.058","article-title":"Evaluation of emotional behaviors in young offspring of C57BL\/6 J mice after gestational and\/or perinatal exposure to nicotine in six different time-windows","volume":"239","author":"Alkam","year":"2013","journal-title":"Behav. Brain Res"},{"key":"10.1016\/j.phrs.2022.106226_bib34","doi-asserted-by":"crossref","first-page":"7042","DOI":"10.1007\/s12035-016-0239-y","article-title":"Protective potential of the glutathione peroxidase-1 gene in abnormal behaviors induced by phencyclidine in mice","volume":"54","author":"Tran","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106226_bib35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/brb3.182","article-title":"Juvenile stress enhances anxiety and alters corticosteroid receptor expression in adulthood","volume":"4","author":"Brydges","year":"2014","journal-title":"Brain Behav."},{"key":"10.1016\/j.phrs.2022.106226_bib36","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1007\/s12035-015-9527-1","article-title":"N-methyl, N-propynyl-2-phenylethylamine (MPPE), a selegiline analog, attenuates MPTP-induced dopaminergic toxicity with guaranteed behavioral safety: involvement of inhibitions of mitochondrial oxidative burdens and p53 gene-elicited pro-apoptotic change","volume":"53","author":"Shin","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106226_bib37","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1523\/JNEUROSCI.3673-13.2014","article-title":"Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors","volume":"34","author":"Zhong","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118494","article-title":"Enhanced neurogenesis is involved in neuroprotection provided by rottlerin against trimethyltin-induced delayed apoptotic neuronal damage","volume":"262","author":"Hwang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2022.106226_bib39","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nn.3732","article-title":"ALK5-dependent TGF-beta signaling is a major determinant of late-stage adult neurogenesis","volume":"17","author":"He","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib40","doi-asserted-by":"crossref","first-page":"21793","DOI":"10.1038\/srep21793","article-title":"Traumatic brain injury causes aberrant migration of adult-born neurons in the hippocampus","volume":"6","author":"Ibrahim","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106226_bib41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fncel.2017.00171","article-title":"Abnormal development of dendrites in adult-born rat hippocampal granule cells induced by cyclophosphamide","volume":"11","author":"Wu","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.20022","article-title":"Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images","volume":"58","author":"Meijering","year":"2004","journal-title":"Cytom. A"},{"key":"10.1016\/j.phrs.2022.106226_bib43","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nmeth.3125","article-title":"Neuronal morphometry directly from bitmap images","volume":"11","author":"Ferreira","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phrs.2022.106226_bib44","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3389\/fphar.2018.00786","article-title":"Long-term stress and concomitant marijuana smoke exposure affect physiology, behavior and adult hippocampal neurogenesis","volume":"9","author":"Rusznak","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2022.106226_bib45","doi-asserted-by":"crossref","first-page":"fcaa153","DOI":"10.1093\/braincomms\/fcaa153","article-title":"Chronic stress induces significant gene expression changes in the prefrontal cortex alongside alterations in adult hippocampal neurogenesis","volume":"2","author":"Musaelyan","year":"2020","journal-title":"Brain Commun."},{"key":"10.1016\/j.phrs.2022.106226_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.20699","article-title":"Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy","volume":"59","author":"Parent","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phrs.2022.106226_bib47","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/sj.emboj.7600079","article-title":"DCX, a new mediator of the JNK pathway","volume":"23","author":"Gdalyahu","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.phrs.2022.106226_bib48","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3390\/cells9020440","article-title":"Impact of JNK and Its substrates on dendritic spine morphology","volume":"9","author":"Komulainen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2022.106226_bib49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0896-6273(03)00852-3","article-title":"Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration","volume":"41","author":"Tanaka","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2022.106226_bib50","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nm.4120","article-title":"Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases","volume":"22","author":"Ni","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2022.106226_bib51","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1158\/1078-0432.CCR-16-0064","article-title":"PI3K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo","volume":"22","author":"Niessner","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2022.106226_bib52","doi-asserted-by":"crossref","first-page":"20189","DOI":"10.1038\/srep20189","article-title":"BKM-120 (Buparlisib): a phosphatidyl-inositol-3 kinase inhibitor with anti-invasive properties in glioblastoma","volume":"6","author":"Speranza","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106226_bib53","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1002\/glia.23485","article-title":"PI3K: A master regulator of brain metastasis-promoting macrophages\/micro","volume":"66","author":"Blazquez","year":"2018","journal-title":"Glia, Glia"},{"key":"10.1016\/j.phrs.2022.106226_bib54","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1523\/JNEUROSCI.0110-07.2007","article-title":"Epigenetic modulation of seizure-induced neurogenesis and cognitive decline","volume":"27","author":"Jessberger","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib55","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.1038\/ncomms7606","article-title":"Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline","volume":"6","author":"Cho","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2022.106226_bib56","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fncel.2018.00266","article-title":"The free radical scavenger N-tert-butyl-alpha-phenylnitrone (PBN) administered to immature rats during status epilepticus alters neurogenesis and has variable effects, both beneficial and detrimental, on long-term outcomes","volume":"12","author":"Kubova","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib57","doi-asserted-by":"crossref","first-page":"15374","DOI":"10.1038\/s41598-020-72380-1","article-title":"Abrogation of atypical neurogenesis and vascular-derived EphA4 prevents repeated mild TBI-induced learning and memory impairments","volume":"10","author":"Greer","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106226_bib58","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuropharm.2013.04.012","article-title":"The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus","volume":"71","author":"Lussier","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2022.106226_bib59","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pnpbp.2015.02.001","article-title":"Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation","volume":"60","author":"Fenton","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2022.106226_bib60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2016.07.005","article-title":"Repeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavior","volume":"333","author":"Sanchez-Vidana","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2022.106226_bib61","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neuroscience.2020.05.014","article-title":"Melatonin reverses the depression-associated behaviour and regulates microglia, fractalkine expression and neurogenesis in adult mice exposed to chronic mild stress","volume":"440","author":"Vega-Rivera","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2022.106226_bib62","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1523\/JNEUROSCI.3632-07.2008","article-title":"Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells","volume":"28","author":"Wang","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib63","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1523\/JNEUROSCI.2817-15.2016","article-title":"Anxiety- and depression-like states lead to pronounced olfactory deficits and impaired adult neurogenesis in mice","volume":"36","author":"Siopi","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib64","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuron.2012.12.038","article-title":"Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus","volume":"77","author":"Kheirbek","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2022.106226_bib65","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/hipo.22265","article-title":"Functional dissociation of adult-born neurons along the dorsoventral axis of the dentate gyrus","volume":"24","author":"Wu","year":"2014","journal-title":"Hippocampus"},{"key":"10.1016\/j.phrs.2022.106226_bib66","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1523\/JNEUROSCI.2455-20.2020","article-title":"Mossy cells in the dorsal and ventral dentate gyrus differ in their patterns of axonal projections","volume":"41","author":"Houser","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib67","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bpsgos.2021.04.005","article-title":"Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus","volume":"1","author":"Bauer","year":"2021","journal-title":"Biol. Psychiatry Glob. Open Sci."},{"key":"10.1016\/j.phrs.2022.106226_bib68","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.neunet.2005.08.008","article-title":"Recall of memory sequences by interaction of the dentate and CA3: a revised model of the phase precession","volume":"18","author":"Lisman","year":"2005","journal-title":"Neural Netw."},{"key":"10.1016\/j.phrs.2022.106226_bib69","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.pnpbp.2015.01.005","article-title":"Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: additional evidence","volume":"59","author":"Lisboa","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2022.106226_bib70","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbr.2016.08.049","article-title":"Regional specific modulation of neuronal activation associated with nitric oxide synthase inhibitors in an animal model of antidepressant activity","volume":"316","author":"Sherwin","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2022.106226_bib71","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.aan4074","article-title":"Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory","volume":"359","author":"Bui","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.phrs.2022.106226_bib72","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cub.2020.09.074","article-title":"Ventro-dorsal hippocampal pathway gates novelty-induced contextual memory formation","volume":"31","author":"Fredes","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.phrs.2022.106226_bib73","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuroscience.2010.04.023","article-title":"Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats","volume":"168","author":"Brummelte","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2022.106226_bib74","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/hipo.22134","article-title":"Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis","volume":"23","author":"Tanti","year":"2013","journal-title":"Hippocampus"},{"key":"10.1016\/j.phrs.2022.106226_bib75","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/jnc.13253","article-title":"Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease","volume":"135","author":"Deusser","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2022.106226_bib76","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.3390\/molecules26071978","article-title":"Involvement of neuropeptide galanin receptors 2 and 3 in learning, memory and anxiety in aging mice","volume":"26","author":"Locker","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phrs.2022.106226_bib77","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.biopsych.2020.08.026","article-title":"Critical roles of embryonic born dorsal dentate granule neurons for activity-dependent increases in BDNF, adult hippocampal neurogenesis, and antianxiety-like behaviors","volume":"89","author":"Sun","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2022.106226_bib78","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1242\/dev.129.13.3147","article-title":"Control of cortical interneuron migration by neurotrophins and PI3-kinase signaling","volume":"129","author":"Polleux","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.phrs.2022.106226_bib79","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1074\/jbc.M408251200","article-title":"Involvement of the phosphatidylinositol 3-kinase\/rac1 and cdc42 pathways in radial migration of cortical neurons","volume":"280","author":"Konno","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2022.106226_bib80","doi-asserted-by":"crossref","first-page":"E2955","DOI":"10.1073\/pnas.1516321113","article-title":"PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex","volume":"113","author":"Itoh","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2022.106226_bib81","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/nm.3982","article-title":"An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development","volume":"21","author":"Baek","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2022.106226_bib82","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.574382","article-title":"Non-cell-autonomous mechanisms in radial projection neuron migration in the developing cerebral cortex","volume":"8","author":"Hansen","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.phrs.2022.106226_bib83","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/nn1153","article-title":"RNAi reveals doublecortin is required for radial migration in rat neocortex","volume":"6","author":"Bai","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib84","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1523\/JNEUROSCI.4851-09.2010","article-title":"Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reduction","volume":"30","author":"Pramparo","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib85","doi-asserted-by":"crossref","first-page":"7551","DOI":"10.1523\/JNEUROSCI.6716-10.2011","article-title":"Abnormal neuronal migration changes the fate of developing neurons in the postnatal olfactory bulb","volume":"31","author":"Belvindrah","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib86","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/BJ20040324","article-title":"Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5","volume":"381","author":"Graham","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.phrs.2022.106226_bib87","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bbamcr.2019.01.003","article-title":"Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments","volume":"1866","author":"Moslehi","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"key":"10.1016\/j.phrs.2022.106226_bib88","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12964-019-0485-5","article-title":"Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression","volume":"18","author":"Ayanlaja","year":"2020","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.phrs.2022.106226_bib89","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mcn.2006.01.014","article-title":"Site-specific dephosphorylation of doublecortin (DCX) by protein phosphatase 1 (PP1)","volume":"32","author":"Shmueli","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib90","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.bbrc.2006.03.045","article-title":"Neurabin II mediates doublecortin-dephosphorylation on actin filaments","volume":"343","author":"Tsukada","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2022.106226_bib91","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cell.2007.03.023","article-title":"Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist","volume":"129","author":"Bielas","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2022.106226_bib92","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nn.2755","article-title":"Phosphorylation of SCG10\/stathmin-2 determines multipolar stage exit and neuronal migration rate","volume":"14","author":"Westerlund","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib93","doi-asserted-by":"crossref","first-page":"dev180646","DOI":"10.1242\/dev.180646","article-title":"JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons","volume":"147","author":"Myers","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.phrs.2022.106226_bib94","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1073\/pnas.1508545112","article-title":"Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain","volume":"112","author":"Sun","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.phrs.2022.106226_bib95","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1038\/s41467-019-11206-9","article-title":"Lateral dispersion is required for circuit integration of newly generated dentate granule cells","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2022.106226_bib96","doi-asserted-by":"crossref","first-page":"13659","DOI":"10.1523\/JNEUROSCI.1353-15.2015","article-title":"Downregulation of sphingosine 1-phosphate receptor 1 promotes the switch from tangential to radial migration in the OB","volume":"35","author":"Alfonso","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib97","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/jcb.20094","article-title":"G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival","volume":"92","author":"Radeff-Huang","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.phrs.2022.106226_bib98","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1007\/s12035-018-1448-3","article-title":"The role of ceramide and sphingosine-1-phosphate in Alzheimer\u2019s disease and other neurodegenerative disorders","volume":"56","author":"Czubowicz","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106226_bib99","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pneurobio.2009.02.001","article-title":"Cell migration in the normal and pathological postnatal mammalian brain","volume":"88","author":"Cayre","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106226_bib100","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1242\/dev.129.18.4249","article-title":"The chemokine SDF1 regulates migration of dentate granule cells","volume":"129","author":"Bagri","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.phrs.2022.106226_bib101","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.1073\/pnas.092013799","article-title":"Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor","volume":"99","author":"Lu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.phrs.2022.106226_bib102","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/hipo.22180","article-title":"CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrus","volume":"23","author":"Schultheiss","year":"2013","journal-title":"Hippocampus"},{"key":"10.1016\/j.phrs.2022.106226_bib103","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-05738-7","article-title":"Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development","volume":"7","author":"Mimura-Yamamoto","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106226_bib104","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/glia.23324","article-title":"CXCL12-mediated feedback from granule neurons regulates generation and positioning of new neurons in the dentate gyrus","volume":"66","author":"Abe","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.phrs.2022.106226_bib105","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neures.2010.04.006","article-title":"Upregulation of CXCR4 favoring neural-like cells migration via AKT activation","volume":"67","author":"Li","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.phrs.2022.106226_bib106","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12031-014-0279-6","article-title":"Chemotactic responses of neural stem cells to SDF-1alpha correlate closely with their differentiation status","volume":"54","author":"Chen","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib107","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.stemcr.2020.03.003","article-title":"Repulsive guidance molecule A suppresses adult neurogenesis","volume":"14","author":"Isaksen","year":"2020","journal-title":"Stem Cell. Rep."},{"key":"10.1016\/j.phrs.2022.106226_bib108","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1007\/s12035-017-0525-3","article-title":"Tale of the good and the bad Cdk5: remodeling of the actin cytoskeleton in the brain","volume":"55","author":"Shah","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106226_bib109","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.conb.2014.08.013","article-title":"Depression: from psychopathology to pathophysiology","volume":"30","author":"Belzung","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106226_bib110","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/nn.4101","article-title":"Resolving the neural circuits of anxiety","volume":"18","author":"Calhoon","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2022.106226_bib111","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.2174\/1381612043384402","article-title":"Phosphoinositide 3-kinases as targets for therapeutic intervention","volume":"10","author":"Wetzker","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.phrs.2022.106226_bib112","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1158\/1535-7163.MCT-11-1021","article-title":"Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations","volume":"11","author":"Brachmann","year":"2012","journal-title":"Mol. Cancer Ther."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822001712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822001712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:35:45Z","timestamp":1760913345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661822001712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":112,"alternative-id":["S1043661822001712"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106226","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of mice","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106226"}}