{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:12:17Z","timestamp":1790266337289,"version":"4.1.0"},"reference-count":125,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202176"],"award-info":[{"award-number":["7202176"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074254"],"award-info":[{"award-number":["82074254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973689"],"award-info":[{"award-number":["81973689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.phrs.2022.106289","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T02:00:18Z","timestamp":1654480818000},"page":"106289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["The crosstalk between NLRP3 inflammasome and gut microbiome in atherosclerosis"],"prefix":"10.1016","volume":"181","author":[{"given":"Xiao-Nan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong-Liang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Ye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.phrs.2022.106289_bib1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/CIRCRESAHA.118.313816","article-title":"Atherosclerosis","volume":"123","author":"Kobiyama","year":"2018","journal-title":"Circ. Res."},{"issue":"13","key":"10.1016\/j.phrs.2022.106289_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136702","article-title":"Renin-angiotensin system in pathogenesis of atherosclerosis and treatment of CVD","volume":"22","author":"Poznyak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.phrs.2022.106289_bib3","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.18632\/aging.102231","article-title":"TPM2 as a potential predictive biomarker for atherosclerosis","volume":"11","author":"Meng","year":"2019","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ctm2.13","article-title":"NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases","volume":"10","author":"Wang","year":"2020","journal-title":"Clin. Transl. Med."},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrcardio.2017.169","article-title":"Atherosclerosis: association between the gut microbiome and atherosclerosis","volume":"14","author":"Barrington","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib6","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/s41467-017-01917-2","article-title":"Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis","volume":"8","author":"Yao","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1161\/CIRCRESAHA.118.313234","article-title":"Gut microbiota increases systemic inflammation and accelerates atherosclerosis","volume":"124","author":"Brandsma","year":"2019","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41568-019-0123-y","article-title":"Diverging inflammasome signals in tumorigenesis and potential targeting","volume":"19","author":"Karki","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/biom9120850","article-title":"Modulatory mechanisms of the NLRP3 inflammasomes in diabetes","volume":"9","author":"Ding","year":"2019","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib10","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41575-018-0054-1","article-title":"Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis","volume":"15","author":"Man","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib11","doi-asserted-by":"crossref","first-page":"21006","DOI":"10.1038\/s41598-020-76497-1","article-title":"NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet","volume":"10","author":"Sokolova","year":"2020","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib12","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202006194","article-title":"The NLRP3-inflammasome as a sensor of organelle dysfunction","volume":"219","author":"Seoane","year":"2020","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.phrs.2022.106289_bib13","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.it.2019.09.005","article-title":"Emerging activators and regulators of inflammasomes and pyroptosis","volume":"40","author":"Xue","year":"2019","journal-title":"Trends Immunol."},{"issue":"8","key":"10.1016\/j.phrs.2022.106289_bib14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"7761","key":"10.1016\/j.phrs.2022.106289_bib15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","article-title":"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.phrs.2022.106289_bib16","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","article-title":"An update on the regulatory mechanisms of NLRP3 inflammasome activation","volume":"18","author":"Paik","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phrs.2022.106289_bib17","article-title":"NLRP3 inflammasome and inflammatory diseases","volume":"2020","author":"Wang","year":"2020","journal-title":"Oxid. Med Cell Longev."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12943-018-0900-3","article-title":"Role of the NLRP3 inflammasome in cancer","volume":"17","author":"Moossavi","year":"2018","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.phrs.2022.106289_bib19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jdermsci.2020.03.001","article-title":"The role of NLRP3 inflammasome in infection-related, immune-mediated and autoimmune skin diseases","volume":"98","author":"Wang","year":"2020","journal-title":"J. Dermatol. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2022.106289_bib20","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.biocel.2010.01.008","article-title":"Nlrp3: an immune sensor of cellular stress and infection","volume":"42","author":"Lamkanfi","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6","key":"10.1016\/j.phrs.2022.106289_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/cells9061552","article-title":"The NLRP3 inflammasome as a critical actor in the inflammaging process","volume":"9","author":"Sebastian-Valverde","year":"2020","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124294","article-title":"Cellular models and assays to study NLRP3 inflammasome biology","volume":"21","author":"Zito","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/genes11020131","article-title":"The roles of the NLRP3 inflammasome in neurodegenerative and metabolic diseases and in relevant advanced therapeutic interventions","volume":"11","author":"Pirzada","year":"2020","journal-title":"Genes"},{"key":"10.1016\/j.phrs.2022.106289_bib24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fendo.2020.00080","article-title":"Role of the NLRP3 inflammasome in preeclampsia","volume":"11","author":"Shirasuna","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020872","article-title":"Structure, activation and regulation of NLRP3 and AIM2 inflammasomes","volume":"22","author":"Sharma","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.phrs.2022.106289_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168780","article-title":"New approach to target NLRP3 inflammasome activation","volume":"22","author":"Akther","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2022.106289_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.609441","article-title":"Distinct molecular mechanisms underlying potassium efflux for NLRP3 inflammasome activation","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Immunol."},{"issue":"13","key":"10.1016\/j.phrs.2022.106289_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2022.106289_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101216","article-title":"Corrigendum to \u2018Reactive oxygen species promote tubular injury in diabetic nephropathy: the role of the mitochondrial ros-txnip-nlrp3 biological axis\u2019 [Redox Biology 16 (2018) 32-46]","volume":"24","author":"Han","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2022.106289_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123034","article-title":"Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway","volume":"399","author":"Jia","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib31","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.4049\/jimmunol.1401624","article-title":"Neutrophil IL-1beta processing induced by pneumolysin is mediated by the NLRP3\/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux","volume":"194","author":"Karmakar","year":"2015","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.phrs.2022.106289_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cells9051219","article-title":"The roles of endoplasmic reticulum in NLRP3 inflammasome activation","volume":"9","author":"Zhou","year":"2020","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.phrs.2022.106289_bib33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2015.08.008","article-title":"Endoplasmic reticulum stress activates the inflammasome via NLRP3- and caspase-2-driven mitochondrial damage","volume":"43","author":"Bronner","year":"2015","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.phrs.2022.106289_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41575-019-0250-7","article-title":"Regulation of intestinal lipid metabolism: current concepts and relevance to disease","volume":"17","author":"Ko","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.phrs.2022.106289_bib35","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.chom.2020.02.009","article-title":"Feeling the burn: intestinal epithelial cells modify their lipid metabolism in response to bacterial fermentation products","volume":"27","author":"Wen","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib36","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1172\/JCI78253","article-title":"UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis","volume":"125","author":"Moon","year":"2015","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.phrs.2022.106289_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102985","article-title":"Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis","volume":"60","author":"Niyonzima","year":"2020","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.phrs.2022.106289_bib38","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phrs.2022.106289_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev-nutr-071816-064836","article-title":"Fatty acids and NLRP3 inflammasome-mediated inflammation in metabolic tissues","volume":"37","author":"Ralston","year":"2017","journal-title":"Annu Rev. Nutr."},{"key":"10.1016\/j.phrs.2022.106289_bib40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.canlet.2020.08.033","article-title":"Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer","volume":"491","author":"Qiao","year":"2020","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00894-018-3886-2","article-title":"Roles of the inflammasome in the gutliver axis (Review)","volume":"19","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume":"15","author":"Jia","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.phrs.2022.106289_bib43","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1136\/gutjnl-2018-316670","article-title":"Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis","volume":"68","author":"Liao","year":"2019","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.phrs.2022.106289_bib44","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/hep.31228","article-title":"Intestinal microbiome-macrophage crosstalk contributes to cholestatic liver disease by promoting intestinal permeability in mice","volume":"72","author":"Isaacs-Ten","year":"2020","journal-title":"Hepatology"},{"issue":"7630","key":"10.1016\/j.phrs.2022.106289_bib45","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nature20138","article-title":"Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs","volume":"539","author":"Cummings","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cyto.2015.06.017","article-title":"The interleukin (IL)-1 cytokine family--balance between agonists and antagonists in inflammatory diseases","volume":"76","author":"Palomo","year":"2015","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib47","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.cmet.2020.09.004","article-title":"The gut microbiota at the service of immunometabolism","volume":"32","author":"Michaudel","year":"2020","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib48","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/imr.12608","article-title":"Metabolic regulation of NLRP3","volume":"281","author":"Hughes","year":"2018","journal-title":"Immunol. Rev."},{"issue":"3","key":"10.1016\/j.phrs.2022.106289_bib49","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.cell.2016.05.076","article-title":"Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan","volume":"166","author":"Wolf","year":"2016","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib50","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cmet.2019.10.015","article-title":"Pharmacological activation of pyruvate kinase M2 Inhibits CD4(+) t cell pathogenicity and suppresses autoimmunity","volume":"31","author":"Angiari","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.phrs.2022.106289_bib51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.clinbiochem.2017.12.007","article-title":"Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD indices","volume":"53","author":"Almousa","year":"2018","journal-title":"Clin. Biochem."},{"issue":"5","key":"10.1016\/j.phrs.2022.106289_bib52","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1093\/rheumatology\/keaa473","article-title":"PKM2-dependent glycolysis promotes skeletal muscle cell pyroptosis by activating the NLRP3 inflammasome in dermatomyositis\/polymyositis","volume":"60","author":"Liu","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.phrs.2022.106289_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154231","article-title":"The impact of hyperglycaemia on PKM2-mediated NLRP3 inflammasome\/stress granule signalling in macrophages and its correlation with plaque vulnerability: an in vivo and in vitro study","volume":"107","author":"Li","year":"2020","journal-title":"Metab. Clin. Exp."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib54","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40168-020-00821-0","article-title":"Gut microbiota and cardiovascular disease: opportunities and challenges","volume":"8","author":"Kazemian","year":"2020","journal-title":"Microbiome"},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/nu13041244","article-title":"Short-chain fatty acids, maternal microbiota and metabolism in pregnancy","volume":"13","author":"Zietek","year":"2021","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib56","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5853\/jos.2019.00472","article-title":"Gut microbiota and ischemic stroke: the role of trimethylamine N-oxide","volume":"21","author":"Nam","year":"2019","journal-title":"J. Stroke"},{"issue":"5","key":"10.1016\/j.phrs.2022.106289_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051214","article-title":"Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer","volume":"20","author":"Zeng","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2022.106289_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100889","article-title":"The NLRP3 inflammasome: mechanism of action, role in disease and therapies","volume":"76","author":"Wang","year":"2020","journal-title":"Mol. Asp. Med."},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib59","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.cmet.2017.03.007","article-title":"Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis","volume":"25","author":"Hao","year":"2017","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib60","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1182\/blood.2019003990","article-title":"The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice","volume":"136","author":"Wu","year":"2020","journal-title":"Blood"},{"issue":"17","key":"10.1016\/j.phrs.2022.106289_bib61","doi-asserted-by":"crossref","first-page":"21470","DOI":"10.18632\/aging.203487","article-title":"SCFAs promote intestinal double-negative T cells to regulate the inflammatory response mediated by NLRP3 inflammasome","volume":"13","author":"Ruan","year":"2021","journal-title":"Aging"},{"issue":"10","key":"10.1016\/j.phrs.2022.106289_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/nu10101398","article-title":"Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target","volume":"10","author":"Janeiro","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.phrs.2022.106289_bib63","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3389\/fphys.2019.00866","article-title":"Trimethylamine N-oxide exacerbates cardiac fibrosis via activating the NLRP3 inflammasome","volume":"10","author":"Li","year":"2019","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib64","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12967-016-0911-z","article-title":"Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes\/macrophages","volume":"14","author":"Zhang","year":"2016","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib65","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.bbrc.2017.06.075","article-title":"Trimethylamine N-oxide prime NLRP3 inflammasome via inhibiting ATG16L1-induced autophagy in colonic epithelial cells","volume":"490","author":"Yue","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/advances\/nmy125","article-title":"Effects of weight-loss interventions on short-chain fatty acid concentrations in blood and feces of adults: a systematic review","volume":"10","author":"Sowah","year":"2019","journal-title":"Adv. Nutr."},{"issue":"7","key":"10.1016\/j.phrs.2022.106289_bib67","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-020-0352-5","article-title":"T cell subsets and functions in atherosclerosis","volume":"17","author":"Saigusa","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"7","key":"10.1016\/j.phrs.2022.106289_bib68","first-page":"389","article-title":"Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities","volume":"16","author":"Back","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phrs.2022.106289_bib69","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8563845","article-title":"Targeting early atherosclerosis: a focus on oxidative stress and inflammation","volume":"2019","author":"Marchio","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib70","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/path.4357","article-title":"NLRPs, microbiota, and gut homeostasis: unravelling the connection","volume":"233","author":"Zambetti","year":"2014","journal-title":"J. Pathol."},{"issue":"9","key":"10.1016\/j.phrs.2022.106289_bib71","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201800027","article-title":"The microbiota-inflammasome hypothesis of major depression","volume":"40","author":"Inserra","year":"2018","journal-title":"Bioessays"},{"issue":"7","key":"10.1016\/j.phrs.2022.106289_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8070205","article-title":"NLPR3 inflammasomes and their significance for atherosclerosis","volume":"8","author":"Poznyak","year":"2020","journal-title":"Biomedicines"},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib73","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11883-020-00892-2","article-title":"The role of the gut microbiota in coronary heart disease","volume":"22","author":"Liu","year":"2020","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.phrs.2022.106289_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101806","article-title":"Microbiota-gut-brain axis in health and disease: is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?","volume":"191","author":"Pellegrini","year":"2020","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.phrs.2022.106289_bib75","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1080\/19490976.2020.1770042","article-title":"The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice","volume":"11","author":"Li","year":"2020","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib76","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","article-title":"Immunity and Inflammation in Atherosclerosis","volume":"124","author":"Wolf","year":"2019","journal-title":"Circ. Res"},{"issue":"13","key":"10.1016\/j.phrs.2022.106289_bib77","first-page":"2525","article-title":"Inflammation during the life cycle of the atherosclerotic plaque","volume":"117","author":"Libby","year":"2021","journal-title":"Cardiovasc Res"},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib78","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/mi.2017.19","article-title":"Inflammasomes and intestinal inflammation","volume":"10","author":"Zmora","year":"2017","journal-title":"Mucosal Immunol."},{"issue":"9","key":"10.1016\/j.phrs.2022.106289_bib79","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006347","article-title":"Trimethylamine-N-oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway","volume":"6","author":"Chen","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2022.106289_bib80","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbrc.2016.11.017","article-title":"Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome","volume":"481","author":"Sun","year":"2016","journal-title":"Biochem. Biophys. Res Commun."},{"issue":"7","key":"10.1016\/j.phrs.2022.106289_bib81","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1161\/ATVBAHA.119.312725","article-title":"Inhibition of MPO (Myeloperoxidase) attenuates endothelial dysfunction in mouse models of vascular inflammation and atherosclerosis","volume":"39","author":"Cheng","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.phrs.2022.106289_bib82","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCRESAHA.118.314402","article-title":"Endothelial Foxp1 suppresses atherosclerosis via modulation of Nlrp3 inflammasome activation","volume":"125","author":"Zhuang","year":"2019","journal-title":"Circ. Res."},{"issue":"13","key":"10.1016\/j.phrs.2022.106289_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133294","article-title":"Modulation of nitric oxide synthases by oxidized LDLs: role in vascular inflammation and atherosclerosis development","volume":"20","author":"Gliozzi","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2022.106289_bib84","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/FJC.0000000000000747","article-title":"Dietary apigenin reduces induction of LOX-1 and NLRP3 expression, leukocyte adhesion, and acetylated low-density lipoprotein uptake in human endothelial cells exposed to trimethylamine-N-oxide","volume":"74","author":"Yamagata","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib85","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000484623","article-title":"Trimethylamine-N-oxide instigates NLRP3 inflammasome activation and endothelial dysfunction","volume":"44","author":"Boini","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.phrs.2022.106289_bib86","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1038\/ncomms7734","article-title":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome","volume":"6","author":"Macia","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phrs.2022.106289_bib87","first-page":"1","article-title":"Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs)","volume":"66","author":"Ratajczak","year":"2019","journal-title":"Acta Biochim. Pol."},{"issue":"7","key":"10.1016\/j.phrs.2022.106289_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0276-5","article-title":"Acetate attenuates inflammasome activation through GPR43-mediated Ca(2+)-dependent NLRP3 ubiquitination","volume":"51","author":"Xu","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"7","key":"10.1016\/j.phrs.2022.106289_bib89","doi-asserted-by":"crossref","first-page":"660","DOI":"10.5551\/jat.RV17006","article-title":"Are short chain fatty acids in gut microbiota defensive players for inflammation and atherosclerosis?","volume":"24","author":"Ohira","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib90","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIRCRESAHA.120.316242","article-title":"Gut microbiota and cardiovascular disease","volume":"127","author":"Witkowski","year":"2020","journal-title":"Circ. Res"},{"key":"10.1016\/j.phrs.2022.106289_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.832092","article-title":"Dysbiosis of gut microbiota and metabolite phenylacetylglutamine in coronary artery disease patients with stent stenosis","volume":"9","author":"Fang","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.phrs.2022.106289_bib92","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.atherosclerosis.2018.04.015","article-title":"Metabolic products of the intestinal microbiome and extremes of atherosclerosis","volume":"273","author":"Bogiatzi","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.phrs.2022.106289_bib93","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.3389\/fimmu.2017.01535","article-title":"The human-associated archaeon methanosphaera stadtmanae is recognized through its RNA and induces TLR8-dependent NLRP3 inflammasome activation","volume":"8","author":"Vierbuchen","year":"2017","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib94","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1021\/acs.chemrestox.8b00306","article-title":"Atypical gasdermin D and mixed lineage kinase domain-like protein leakage aggravates tetrachlorobenzoquinone-induced nod-like receptor protein 3 inflammasome activation","volume":"31","author":"Xia","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.phrs.2022.106289_bib95","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fphys.2017.00319","article-title":"The crosstalk between the gut microbiota and mitochondria during exercise","volume":"8","author":"Clark","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phrs.2022.106289_bib96","article-title":"Quercetin Attenuates Atherosclerotic Inflammation by Inhibiting Galectin-3-NLRP3 Signaling Pathway","author":"Li","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"issue":"11","key":"10.1016\/j.phrs.2022.106289_bib97","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1016\/j.clnu.2020.02.027","article-title":"The Mediterranean diet decreases prothrombotic microvesicle release in asymptomatic individuals at high cardiovascular risk","volume":"39","author":"Chiva-Blanch","year":"2020","journal-title":"Clin. Nutr."},{"issue":"5","key":"10.1016\/j.phrs.2022.106289_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/nu11051155","article-title":"Dietary fiber, atherosclerosis, and cardiovascular disease","volume":"11","author":"Soliman","year":"2019","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.phrs.2022.106289_bib99","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1038\/s41366-018-0187-x","article-title":"Konjaku flour reduces obesity in mice by modulating the composition of the gut microbiota","volume":"43","author":"Kang","year":"2019","journal-title":"Int. J. Obes."},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib100","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700473","article-title":"Soluble dietary fiber reduces trimethylamine metabolism via gut microbiota and co-regulates host AMPK pathways","volume":"61","author":"Li","year":"2017","journal-title":"Mol. Nutr. Food Res"},{"issue":"19","key":"10.1016\/j.phrs.2022.106289_bib101","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1021\/acs.jafc.8b00380","article-title":"Cereal fiber ameliorates high-fat\/cholesterol-diet-induced atherosclerosis by modulating the NLRP3 inflammasome pathway in ApoE(-\/-) Mice","volume":"66","author":"Zhang","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib102","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/CIRCRESAHA.118.311362","article-title":"NLRP3 inflammasome and the IL-1 pathway in atherosclerosis","volume":"122","author":"Grebe","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2022.106289_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117747","article-title":"Rapamycin and MCC950 modified gut microbiota in experimental autoimmune encephalomyelitis mouse by brain gut axis","volume":"253","author":"Xu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2022.106289_bib104","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.toxlet.2020.09.018","article-title":"Colchicine increases intestinal permeability, suppresses inflammatory responses, and alters gut microbiota in mice","volume":"334","author":"Shi","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phrs.2022.106289_bib105","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jconrel.2020.11.064","article-title":"Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy","volume":"329","author":"Ma","year":"2021","journal-title":"J. Control Release"},{"issue":"6","key":"10.1016\/j.phrs.2022.106289_bib106","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Tapia-Abell\u00e1n","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phrs.2022.106289_bib107","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.intimp.2019.05.006","article-title":"NLRP3 inflammasome as a treatment target in atherosclerosis: a focus on statin therapy","volume":"73","author":"Parsamanesh","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phrs.2022.106289_bib108","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3389\/fmicb.2019.01947","article-title":"Alterations in gut microbiota by statin therapy and possible intermediate effects on hyperglycemia and hyperlipidemia","volume":"10","author":"Kim","year":"2019","journal-title":"Front. Microbiol"},{"issue":"14","key":"10.1016\/j.phrs.2022.106289_bib109","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1042\/CS20160090","article-title":"Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation","volume":"130","author":"Robertson","year":"2016","journal-title":"Clin. Sci."},{"issue":"9","key":"10.1016\/j.phrs.2022.106289_bib110","doi-asserted-by":"crossref","first-page":"914","DOI":"10.5551\/jat.4929","article-title":"Molecular mechanisms of ezetimibe-induced attenuation of postprandial hypertriglyceridemia","volume":"17","author":"Sandoval","year":"2010","journal-title":"J. Atheroscler. Thromb."},{"issue":"12","key":"10.1016\/j.phrs.2022.106289_bib111","article-title":"Ezetimibe impairs transcellular lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells","volume":"1865","author":"Nakano","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"10","key":"10.1016\/j.phrs.2022.106289_bib112","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1080\/15548627.2017.1356977","article-title":"Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition","volume":"13","author":"Kim","year":"2017","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib113","doi-asserted-by":"crossref","first-page":"e02210","DOI":"10.1128\/mBio.02210-15","article-title":"Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota","volume":"7","author":"Chen","year":"2016","journal-title":"mBio"},{"issue":"9","key":"10.1016\/j.phrs.2022.106289_bib114","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/intimm\/dxv018","article-title":"Resveratrol inhibits the acetylated alpha-tubulin-mediated assembly of the NLRP3-inflammasome","volume":"27","author":"Misawa","year":"2015","journal-title":"Int Immunol."},{"key":"10.1016\/j.phrs.2022.106289_bib115","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.biopha.2018.08.148","article-title":"Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-\/- mice","volume":"107","author":"Shi","year":"2018","journal-title":"Biomed. Pharm."},{"issue":"2","key":"10.1016\/j.phrs.2022.106289_bib116","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1124\/mol.116.106617","article-title":"Orally administered berberine modulates hepatic lipid metabolism by altering microbial bile acid metabolism and the intestinal FXR signaling pathway","volume":"91","author":"Sun","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phrs.2022.106289_bib117","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.intimp.2016.12.031","article-title":"Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats","volume":"44","author":"Dinesh","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"45","key":"10.1016\/j.phrs.2022.106289_bib118","doi-asserted-by":"crossref","first-page":"12651","DOI":"10.1021\/acs.jafc.0c05800","article-title":"Naringin alleviates atherosclerosis in apoE(-\/-) mice by regulating cholesterol metabolism involved in gut microbiota remodeling","volume":"68","author":"Wang","year":"2020","journal-title":"J. Agric. Food Chem."},{"issue":"50","key":"10.1016\/j.phrs.2022.106289_bib119","doi-asserted-by":"crossref","first-page":"13133","DOI":"10.1021\/acs.jafc.8b03942","article-title":"Protective effect of naringin on DSS-induced ulcerative colitis in mice","volume":"66","author":"Cao","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phrs.2022.106289_bib120","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.621339","article-title":"Ferulic acid ameliorates atherosclerotic injury by modulating gut microbiota and lipid metabolism","volume":"12","author":"Gu","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.phrs.2022.106289_bib121","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.lfs.2016.02.004","article-title":"Targeting inflammatory mediators with ferulic acid, a dietary polyphenol, for the suppression of monosodium urate crystal-induced inflammation in rats","volume":"148","author":"Doss","year":"2016","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.phrs.2022.106289_bib122","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/s41591-018-0128-1","article-title":"Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential","volume":"24","author":"Roberts","year":"2018","journal-title":"Nat. Med"},{"issue":"5","key":"10.1016\/j.phrs.2022.106289_bib123","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1165\/rcmb.2017-0086OC","article-title":"Intermittent hypoxia and hypercapnia accelerate atherosclerosis, partially via trimethylamine-oxide","volume":"57","author":"Xue","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"4","key":"10.1016\/j.phrs.2022.106289_bib124","article-title":"The potential of probiotics in the prevention and treatment of atherosclerosis","volume":"64","author":"O\u2019Morain","year":"2020","journal-title":"Mol. Nutr. Food Res"},{"issue":"3","key":"10.1016\/j.phrs.2022.106289_bib125","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/19490976.2017.1293224","article-title":"Fecal microbiota transplantation in metabolic syndrome: history, present and future","volume":"8","author":"de Groot","year":"2017","journal-title":"Gut Microbes"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822002341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822002341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:22:20Z","timestamp":1777605740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661822002341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":125,"alternative-id":["S1043661822002341"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106289","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The crosstalk between NLRP3 inflammasome and gut microbiome in atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106289","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106289"}}