{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:01:33Z","timestamp":1790949693510,"version":"4.1.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.phrs.2022.106347","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T18:48:40Z","timestamp":1657392520000},"page":"106347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Discovery of novel targets in a complex regional pain syndrome mouse model by transcriptomics: TNF and JAK-STAT pathways"],"prefix":"10.1016","volume":"182","author":[{"given":"Krisztina","family":"Poh\u00f3czky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Kun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolett","family":"Szentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00edmea","family":"Acz\u00e9l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Urb\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Gyenesei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"B\u00f6lcskei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Sz\u0151ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Sensi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"D\u00e9nes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Goebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria","family":"T\u00e9kus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Helyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2022.106347_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fnmol.2018.00219","article-title":"Transcriptional alterations in the trigeminal ganglia, nucleus and peripheral blood mononuclear cells in a rat orofacial pain model","volume":"11","author":"Acz\u00e9l","year":"2018","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.phrs.2022.106347_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12886-016-0262-9","article-title":"Protective effect of etanercept, an inhibitor of tumor necrosis factor-\u03b1, in a rat model of retinal ischemia","volume":"16","author":"Bae","year":"2016","journal-title":"BMC Ophthalmol."},{"issue":"1102","key":"10.1016\/j.phrs.2022.106347_bib3","article-title":"The rodent Tibia fracture model: a critical review and comparison with the complex regional pain syndrome literature","volume":"19","author":"Birklein","year":"2018","journal-title":"J. Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib4","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1097\/01.j.pain.0000460344.54470.20","article-title":"Complex regional pain syndrome\u2014significant progress in understanding","volume":"156","author":"Birklein","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib5","first-page":"713","article-title":"An update on the pathophysiology of complex regional","volume":"113","author":"Bruehl","year":"2010","journal-title":"Pain Syndr. Anesthesiol."},{"key":"10.1016\/j.phrs.2022.106347_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ncpneuro0033","article-title":"Autoimmune channelopathies","volume":"1","author":"Buckley","year":"2005","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.phrs.2022.106347_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.sjpain.2014.10.002","article-title":"Perspectives in Pain Research 2014: neuroinflammation and glial cell activation: the cause of transition from acute to chronic pain?","volume":"6","author":"Cairns","year":"2015","journal-title":"Scand. J. Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pupt.2017.01.002","article-title":"Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS","volume":"43","author":"Calama","year":"2017","journal-title":"Pulm. Pharm. Ther."},{"key":"10.1016\/j.phrs.2022.106347_bib9","first-page":"12","article-title":"Motor coordination and balance in rodents","volume":"8","author":"Carter","year":"2001","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.phrs.2022.106347_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2017.55","article-title":"CD27 expression and its association with clinical outcome in children and adults with pro-B acute lymphoblastic leukemia","volume":"7","author":"Chen","year":"2017","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.phrs.2022.106347_bib11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12974-020-01834-0","article-title":"Expression profiling of spinal cord dorsal horn in a rat model of complex regional pain syndrome type-I uncovers potential mechanisms mediating pain and neuroinflammation responses","volume":"17","author":"Chen","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phrs.2022.106347_bib12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1471-4159.2010.06969.x","article-title":"Therapeutic evaluation of etanercept in a model of traumatic brain injury","volume":"115","author":"Chio","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2022.106347_bib13","first-page":"22","article-title":"Initiators of classical and lectin complement pathways are differently engaged after traumatic brain injury-time-dependent changes in the cortex, striatum, thalamus and hippocampus in a mouse model","author":"Ciechanowska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2022.106347_bib14","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1097\/j.pain.0000000000001607","article-title":"Longitudinal translocator protein-18\u2009kDa-positron emission tomography imaging of peripheral and central myeloid cells in a mouse model of complex regional pain syndrome","volume":"160","author":"Cropper","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib15","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918799127","article-title":"Autoinflammatory and autoimmune contributions to complex regional pain syndrome","volume":"14","author":"David Clark","year":"2018","journal-title":"Mol. Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib16","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/papr.12078","article-title":"Report of a preliminary discontinued double-blind, randomized, placebo-controlled trial of the anti-TNF-\u03b1 chimeric monoclonal antibody infliximab in complex regional pain syndrome","volume":"13","author":"Dirckx","year":"2013","journal-title":"Pain Pract."},{"key":"10.1016\/j.phrs.2022.106347_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phrs.2022.106347_bib18","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1124\/dmd.113.054940","article-title":"The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans","volume":"42","author":"Dowty","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phrs.2022.106347_bib19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/papr.12070","article-title":"Anti tumor necrosis factor - alpha adalimumab for complex regional pain syndrome type 1 (CRPS-I): a case series","volume":"13","author":"Eisenberg","year":"2013","journal-title":"Pain Pract."},{"key":"10.1016\/j.phrs.2022.106347_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neuroscience.2011.11.046","article-title":"The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger-Westphal nucle","volume":"202","author":"Gaszner","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2022.106347_bib21","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1124\/jpet.105.097188","article-title":"Immunomodulatory effects of etanercept in an experimental model of spinal cord injury","volume":"316","author":"Genovese","year":"2006","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.phrs.2022.106347_bib22","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.4049\/jimmunol.1003668","article-title":"Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)","volume":"186","author":"Ghoreschi","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2022.106347_bib23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/ejp.1362","article-title":"Standards for the diagnosis and management of complex regional pain syndrome: results of a European Pain Federation task force","volume":"23","author":"Goebel","year":"2019","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib24","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1097\/j.pain.0000000000002245","article-title":"The Valencia consensus-based adaptation of the IASP complex regional pain syndrome diagnostic criteria","volume":"162","author":"Goebel","year":"2021","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib25","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.autrev.2012.10.015","article-title":"Complex regional pain syndrome, prototype of a novel kind of autoimmune disease","volume":"12","author":"Goebel","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.phrs.2022.106347_bib26","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1111\/pme.12601","article-title":"Treatment of long-standing complex regional pain syndrome with therapeutic plasma exchange: a preliminary case series of patients treated in 2008\u20132014","volume":"15","author":"Goebel","year":"2014","journal-title":"Pain Med."},{"key":"10.1016\/j.phrs.2022.106347_bib27","first-page":"131","article-title":"Passive transfer of fibromyalgia symptoms from patients to mice","author":"Goebel","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2022.106347_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/ana.20400","article-title":"Intravenous immunoglobulin response and evidence for pathogenic antibodies in a case of complex regional pain syndrome 1","volume":"57","author":"Goebel","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phrs.2022.106347_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10571-020-00832-3","article-title":"Bradykinin receptors play a critical role in the chronic post-ischaemia pain model","volume":"41","author":"Gon\u00e7alves","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106347_bib30","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbrc.2016.07.067","article-title":"Global analysis of transcriptome in dorsal root ganglia following peripheral nerve injury in rats","volume":"478","author":"Gong","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2022.106347_bib31","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1213\/ANE.0000000000005440","article-title":"Dimethyl fumarate reduces oxidative stress and pronociceptive immune responses in a murine model of complex regional pain syndrome","volume":"132","author":"Guo","year":"2021","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.phrs.2022.106347_bib32","article-title":"Of mice, microglia, and (wo)men: a case series and mechanistic investigation of hydroxychloroquine for complex regional pain syndrome","volume":"5","author":"Haight","year":"2020","journal-title":"Pain Rep."},{"key":"10.1016\/j.phrs.2022.106347_bib33","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s10753-019-00964-9","article-title":"Short-term effects of sepsis and the impact of aging on the transcriptional profile of different brain regions","volume":"42","author":"Hamasaki","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.phrs.2022.106347_bib34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.pain.2010.04.030","article-title":"Validation of proposed diagnostic criteria (the \u201cBudapest Criteria\u201d) for complex regional pain syndrome","volume":"150","author":"Harden","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib35","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/annrheumdis-2016-210322","article-title":"Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study","volume":"76","author":"van der Heijde","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phrs.2022.106347_bib36","first-page":"116","article-title":"Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1\u2013induced mechanisms","author":"Helyes","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phrs.2022.106347_bib37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phrs.2022.106347_bib38","first-page":"318","article-title":"The mechanism of action of tofacitinib \u2013 an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis","volume":"34","author":"Hodge","year":"2016","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.phrs.2022.106347_bib39","doi-asserted-by":"crossref","first-page":"31851","DOI":"10.1038\/srep31851","article-title":"Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106347_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpain.2020.01.007","article-title":"Electroacupuncture alleviates mechanical allodynia in a rat model of complex regional pain syndrome type-I via suppressing spinal CXCL12\/CXCR4 signaling","author":"Hu","year":"2020","journal-title":"J. Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib41","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/exd.13060","article-title":"Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers","volume":"25","author":"Jabbari","year":"2016","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.phrs.2022.106347_bib42","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000005735","article-title":"[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: a pilot study","volume":"96","author":"Jeon","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.phrs.2022.106347_bib43","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/pm\/pny111","article-title":"Brain metabolites and peripheral biomarkers associated with neuroinflammation in complex regional pain syndrome Using [11C]-(R)-PK11195 positron emission tomography and magnetic resonance spectroscopy: a pilot study","volume":"20","author":"Jung","year":"2019","journal-title":"Pain Med."},{"key":"10.1016\/j.phrs.2022.106347_bib44","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2147\/JPR.S166624","article-title":"Anti-allodynic effect of interleukin 10 in a mouse model of complex regional pain syndrome through reduction of NK1 receptor expression of microglia in the spinal cord","volume":"11","author":"Kim","year":"2018","journal-title":"J. Pain Res."},{"key":"10.1016\/j.phrs.2022.106347_bib45","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s11055-016-0231-z","article-title":"Brain microglia and microglial markers","volume":"46","author":"Korzhevskii","year":"2016","journal-title":"Neurosci. Behav. Physiol."},{"key":"10.1016\/j.phrs.2022.106347_bib46","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/jcph.1029","article-title":"Pharmacokinetics, immunogenicity, and efficacy of etanercept in pediatric patients with moderate to severe plaque psoriasis","volume":"58","author":"Langley","year":"2018","journal-title":"J. Clin. Pharm."},{"key":"10.1016\/j.phrs.2022.106347_bib47","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.phrs.2022.106347_bib48","article-title":"Anti-allodynic effects of polydeoxyribonucleotide in an animal model of neuropathic pain and complex regional pain syndrome","volume":"35","author":"Lee","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.phrs.2022.106347_bib49","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2147\/DDDT.S82599","article-title":"Profile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasis","volume":"10","author":"Di Lernia","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.phrs.2022.106347_bib50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jaad.2015.06.045","article-title":"Treatment of recalcitrant atopic dermatitis with the oral Janus kinase inhibitor tofacitinib citrate","volume":"73","author":"Levy","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.phrs.2022.106347_bib51","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.pain.2014.09.007","article-title":"Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome","volume":"155","author":"Li","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib52","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bbi.2021.02.015","article-title":"IL-6 signaling mediates the germinal center response, IgM production and nociceptive sensitization in male mice after tibia fracture","volume":"94","author":"Li","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2022.106347_bib53","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.bbi.2020.05.029","article-title":"Germinal center formation, immunoglobulin production and hindlimb nociceptive sensitization after tibia fracture","volume":"88","author":"Li","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2022.106347_bib54","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz114","article-title":"The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2022.106347_bib55","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1007\/s12035-021-02521-8","article-title":"Hypercholesterolemia and 27-hydroxycholesterol increase S100A8 and RAGE expression in the brain: a link between cholesterol, alarmins, and neurodegeneration","volume":"58","author":"Loera-Valencia","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2022.106347_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2020.04.037","article-title":"Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I","author":"De Logu","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phrs.2022.106347_bib57","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","article-title":"Pathview: an R\/Bioconductor package for pathway-based data integration and visualization","volume":"29","author":"Luo","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phrs.2022.106347_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079523","article-title":"Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia","volume":"8","author":"Manteniotis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2022.106347_bib59","article-title":"Complex regional pain syndrome evolving to full-blown fibromyalgia: a proposal of common mechanisms","author":"Mart\u00ednez-Lav\u00edn","year":"2020","journal-title":"J. Clin. Rheumatol. Pract. Rep. Rheum. Musculoskelet. Dis."},{"key":"10.1016\/j.phrs.2022.106347_bib60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00540-018-2579-4","article-title":"Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain","volume":"33","author":"Matsuda","year":"2019","journal-title":"J. Anesth."},{"key":"10.1016\/j.phrs.2022.106347_bib61","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jneuroim.2007.05.001","article-title":"Neutrophils rarely invade dorsal root ganglia after peripheral nerve lesions","volume":"187","author":"McLachlan","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.phrs.2022.106347_bib62","doi-asserted-by":"crossref","first-page":"16","DOI":"10.31138\/mjr.30.1.16","article-title":"Complex Regional Pain Syndrome: An update.","volume":"30","author":"Misidou","year":"2019","journal-title":"Mediterr. J. Rheumatol."},{"key":"10.1016\/j.phrs.2022.106347_bib63","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pain.2006.09.008","article-title":"The incidence of complex regional pain syndrome: a population-based study","volume":"129","author":"de Mos","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib64","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/rheumatology\/keh483","article-title":"Anti-TNF-alpha therapies: they are all the same (aren\u2019t they?)","volume":"44","author":"Mpofu","year":"2005","journal-title":"Rheumatology"},{"key":"10.1016\/j.phrs.2022.106347_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193492","article-title":"Cerebrospinal fluid sCD27 levels indicate active T cell-mediated inflammation in premanifest Huntington\u2019s disease","volume":"13","author":"Niemel\u00e4","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2022.106347_bib66","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4049\/jimmunol.1400063","article-title":"Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts","volume":"193","author":"Onda","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2022.106347_bib67","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/j.pain.0000000000001217","article-title":"Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research","volume":"159","author":"Ray","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib68","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phrs.2022.106347_bib69","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phrs.2022.106347_bib70","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/ACO.0000000000000114","article-title":"Diagnosis, mechanisms and treatment of complex regional pain syndrome","volume":"27","author":"Rockett","year":"2014","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"10.1016\/j.phrs.2022.106347_bib71","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mehy.2018.07.026","article-title":"A new hypothesis for the pathophysiology of complex regional pain syndrome","volume":"119","author":"Russo","year":"2018","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.phrs.2022.106347_bib72","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1002\/art.11079","article-title":"Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis","volume":"48","author":"Ryckman","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.phrs.2022.106347_bib73","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.4049\/jimmunol.170.6.3233","article-title":"Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8\/A9 induce neutrophil chemotaxis and adhesion","volume":"170","author":"Ryckman","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2022.106347_bib74","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/ejp.1043","article-title":"Chronic stress-induced mechanical hyperalgesia is controlled by capsaicin-sensitive neurones in the mouse","volume":"21","author":"Scheich","year":"2017","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib75","first-page":"149","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the writing committee of the American Society for Apheresis: the seventh special issue","volume":"31","author":"Schwartz","year":"2016","journal-title":"J. Clin. Apher."},{"key":"10.1016\/j.phrs.2022.106347_bib76","first-page":"E51","article-title":"Comparative study of chronic postischemic pain models in mice: O-ring versus tie method","volume":"23","author":"Seo","year":"2020","journal-title":"Pain Phys."},{"key":"10.1016\/j.phrs.2022.106347_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112500","article-title":"Chronic repeated predatory stress induces resistance to quinine adulteration of ethanol in male mice","volume":"382","author":"Shaw","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2022.106347_bib78","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.neurobiolaging.2005.09.033","article-title":"Inflammatory S100A9 and S100A12 proteins in Alzheimer\u2019s disease","volume":"27","author":"Shepherd","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phrs.2022.106347_bib79","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jneumeth.2010.03.026","article-title":"A rotarod test for evaluation of motor skill learning","volume":"189","author":"Shiotsuki","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.phrs.2022.106347_bib80","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/rapm-2018-100064","article-title":"CRPS: what\u2019s in a name? Taxonomy, epidemiology, neurologic, immune and autoimmune considerations","volume":"44","author":"Stanton-Hicks","year":"2019","journal-title":"Reg. Anesth. Pain Med."},{"key":"10.1016\/j.phrs.2022.106347_bib81","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12864-019-5512-9","article-title":"Sex differences in gene regulation in the dorsal root ganglion after nerve injury","volume":"20","author":"Stephens","year":"2019","journal-title":"BMC Genom."},{"key":"10.1016\/j.phrs.2022.106347_bib82","doi-asserted-by":"crossref","DOI":"10.1124\/jpet.104.082487","article-title":"Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice","volume":"314","author":"Szab\u00f3","year":"2005","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.phrs.2022.106347_bib83","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.hcl.2015.08.003","article-title":"New concepts in complex regional pain syndrome","volume":"32","author":"Tajerian","year":"2016","journal-title":"Hand Clin."},{"key":"10.1016\/j.phrs.2022.106347_bib84","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.pain.2013.10.011","article-title":"A CRPS-IgG-transfer-trauma model reproducing inflammatory and positive sensory signs associated with complex regional pain syndrome","volume":"155","author":"T\u00e9kus","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106347_bib85","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2016.11.030","article-title":"Astrocyte contributes to pain development via MMP2-JNK1\/2 signaling in a mouse model of complex regional pain syndrome","volume":"170","author":"Tian","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2022.106347_bib86","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pharmthera.2007.10.001","article-title":"Tumor necrosis factor antagonist mechanisms of action: a comprehensive review","volume":"117","author":"Tracey","year":"2008","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.phrs.2022.106347_bib87","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/ibd\/izy364","article-title":"A JAK1 selective kinase inhibitor and tofacitinib affect macrophage activation and function","volume":"25","author":"De Vries","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.phrs.2022.106347_bib88","first-page":"1067","article-title":"Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part I)","volume":"20","author":"Wang","year":"2014","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.phrs.2022.106347_bib89","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tins.2015.04.003","article-title":"Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker","volume":"38","author":"Yang","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2022.106347_bib90","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/infdis\/jiu179","article-title":"Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis","volume":"210","author":"Ye","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.phrs.2022.106347_bib91","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2147\/JPR.S188758","article-title":"Transcriptome profiling of dorsal root ganglia in a rat model of complex regional pain syndrome type-I reveals potential mechanisms involved in pain","volume":"12","author":"Yin","year":"2019","journal-title":"J. Pain Res."},{"key":"10.1016\/j.phrs.2022.106347_bib92","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s10875-012-9849-y","article-title":"Tofacitinib, a janus kinase inhibitor demonstrates efficacy in an IL-15 transgenic mouse model that recapitulates pathologic manifestations of celiac disease","volume":"33","author":"Yokoyama","year":"2013","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.phrs.2022.106347_bib93","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.pjnns.2018.03.001","article-title":"Effectiveness of complex regional pain syndrome treatment: a systematic review","volume":"52","author":"\u017byluk","year":"2018","journal-title":"Neurol. Neurochir. Pol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822002924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822002924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:42:14Z","timestamp":1760913734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661822002924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":93,"alternative-id":["S1043661822002924"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106347","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel targets in a complex regional pain syndrome mouse model by transcriptomics: TNF and JAK-STAT pathways","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106347"}}