{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:19:19Z","timestamp":1791145159927,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.phrs.2022.106469","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T04:11:00Z","timestamp":1663992660000},"page":"106469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Angiotensin II type-2 receptor activation in alveolar macrophages mediates protection against cigarette smoke-induced chronic obstructive pulmonary disease"],"prefix":"10.1016","volume":"184","author":[{"given":"Dan","family":"Mei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wupeng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis X.L.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quy T.N.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christabel C.M.Y.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.K. Matthew","family":"Heng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.S. Fred","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2022.106469_bib1","first-page":"17","article-title":"Chronic obstructive pulmonary disease","volume":"173","author":"Labaki","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.phrs.2022.106469_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S2213-2600(21)00511-7","article-title":"on behalf of NIHR RESPIRE Global Respiratory Health Unit: Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis","volume":"10","author":"Adeloye","year":"2022","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.phrs.2022.106469_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101544","article-title":"Oxidative stress-based therapeutics in COPD","volume":"33","author":"Barnes","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.phrs.2022.106469_bib4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/antiox11030464","article-title":"The emerging role of macrophages in chronic obstructive pulmonary disease: the potential impact of oxidative stress and extracellular vesicle on macrophage polarization and function","volume":"11","author":"Finicelli","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phrs.2022.106469_bib5","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1038\/s41598-017-07101-2","article-title":"Characterization of lung macrophage subpopulations in COPD patients and controls","volume":"7","author":"Dewhurst","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106469_bib6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.it.2020.08.008","article-title":"Teaching old dogs new tricks? The plasticity of lung alveolar macrophage subsets","volume":"41","author":"Kulikauskaite","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.phrs.2022.106469_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1165\/rcmb.2017-0328ED","article-title":"Monocyte-derived alveolar macrophages: the dark side of lung repair?","volume":"58","author":"McQuattie-Pimentel","year":"2018","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.phrs.2022.106469_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2017.09.002","article-title":"Macrophage polarization and allergic asthma","volume":"191","author":"Saradna","year":"2018","journal-title":"Transl. Res."},{"key":"10.1016\/j.phrs.2022.106469_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000504344","article-title":"Role of metabolic reprogramming in pulmonary innate immunity and its impact on lung diseases","volume":"12","author":"Michaeloudes","year":"2020","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.phrs.2022.106469_bib10","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2022.106469_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s004180000235","article-title":"Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease","volume":"115","author":"Bullock","year":"2001","journal-title":"Histochem. Cell. Biol."},{"key":"10.1016\/j.phrs.2022.106469_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI46215","article-title":"Angiotensin receptor blockade attenuates cigarette smoke\u2013induced lung injury and rescues lung architecture in mice","volume":"122","author":"Podowski","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2022.106469_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coph.2017.12.002","article-title":"Targeting the renin\u2013angiotensin system as novel therapeutic strategy for pulmonary diseases","volume":"40","author":"Tan","year":"2018","journal-title":"Curr. Opin. Pharm."},{"key":"10.1016\/j.phrs.2022.106469_bib14","first-page":"5","article-title":"Angiotensin\u2010(1\u20137)\u2010mediated Mas1 receptor\/NF\u2010\u03baB\u2010p65 signaling is involved in a cigarette smoke\u2010induced chronic obstructive pulmonary disease mouse model","volume":"33","author":"Zhang","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.phrs.2022.106469_bib15","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/med.21449","article-title":"Small\u2010molecule AT2 receptor agonists","volume":"38","author":"Hallberg","year":"2018","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.phrs.2022.106469_bib16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/CS20130515","article-title":"Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison","volume":"128","author":"Villela","year":"2015","journal-title":"Clin. Sci."},{"key":"10.1016\/j.phrs.2022.106469_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/CS20110036","article-title":"Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors","volume":"121","author":"Bosnyak","year":"2011","journal-title":"Clin. Sci."},{"key":"10.1016\/j.phrs.2022.106469_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105223","article-title":"Activation of angiotensin II type-2 receptor protects against cigarette smoke-induced COPD","volume":"161","author":"Mei","year":"2020","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phrs.2022.106469_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172855","article-title":"Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages","volume":"868","author":"Isaksson","year":"2020","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.phrs.2022.106469_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jaci.2016.02.017","article-title":"House dust mite-induced asthma causes oxidative damae and DNA double-strand breaks in the lungs","volume":"138","author":"Chan","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phrs.2022.106469_bib21","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/infdis\/jit400","article-title":"Phagocytic dysfunction of human alveolar macrophages and severity of chronic obstructive pulmonary disease","volume":"208","author":"Berenson","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.phrs.2022.106469_bib22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1136\/thoraxjnl-2013-203669","article-title":"Impaired innate immune alveolar macrophage response and the predilection for COPD exacerbations","volume":"69","author":"Berenson","year":"2014","journal-title":"Thorax"},{"key":"10.1016\/j.phrs.2022.106469_bib23","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS\u2013) vs. alternatively activated macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phrs.2022.106469_bib24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.niox.2011.03.079","article-title":"Nitrative stress in inflammatory lung diseases","volume":"25","author":"Sugiura","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.phrs.2022.106469_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-13888-x","article-title":"Abnormal M1\/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)","volume":"7","author":"Eapen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106469_bib26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41385-020-00356-5","article-title":"Macrophage metabolic reprogramming during chronic lung disease","volume":"14","author":"Ogger","year":"2020","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.phrs.2022.106469_bib27","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1111\/febs.15327","article-title":"Glycolysis \u2013 a key player in the inflammatory response","volume":"287","author":"Soto-Heredero","year":"2020","journal-title":"FEBS J."},{"key":"10.1016\/j.phrs.2022.106469_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40364-020-00251-y","article-title":"Metabolic reprogramming in macrophage responses","volume":"9","author":"Liu","year":"2021","journal-title":"Biomark. Res."},{"key":"10.1016\/j.phrs.2022.106469_bib29","doi-asserted-by":"crossref","first-page":"9624","DOI":"10.1038\/s41598-019-46045-7","article-title":"Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress","volume":"9","author":"Aridgides","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106469_bib30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12931-022-01986-y","article-title":"Roles of sirtuin family members in chronic obstructive pulmonary disease","volume":"23","author":"Zhang","year":"2022","journal-title":"Respir. Res."},{"key":"10.1016\/j.phrs.2022.106469_bib31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.chest.2017.05.004","article-title":"Decreased serum sirtuin-1 in chronic obstructive pulmonary disease","volume":"152","author":"Yanagisawa","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.phrs.2022.106469_bib32","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1164\/rccm.200708-1269OC","article-title":"SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease","volume":"177","author":"Rajendrasozhan","year":"2008","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"10.1016\/j.phrs.2022.106469_bib33","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.phrs.2022.106469_bib34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1152\/ajplung.00308.2006","article-title":"Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA\/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging","volume":"292","author":"Yang","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.phrs.2022.106469_bib35","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/ATVBAHA.108.166991","article-title":"SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells","volume":"28","author":"Miyazaki","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.phrs.2022.106469_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2018.01.043","article-title":"The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system","volume":"270","author":"Kim","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.phrs.2022.106469_bib37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI46215","article-title":"Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice","volume":"122","author":"Podowski","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2022.106469_bib38","doi-asserted-by":"crossref","first-page":"00394","DOI":"10.1183\/23120541.00394-2020","article-title":"Losartan reduces cigarette smoke-induced airway inflammation and mucus hypersecretion","volume":"7","author":"Kim","year":"2021","journal-title":"ERJ Open Res."},{"key":"10.1016\/j.phrs.2022.106469_bib39","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.3748\/wjg.v21.i26.8021","article-title":"Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation","volume":"21","author":"Pantazi","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phrs.2022.106469_bib40","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/17476348.2020.1732821","article-title":"Role of p38-mitogen-activated protein kinase in COPD: pathobiological implications and therapeutic perspectives","volume":"14","author":"Pelaia","year":"2020","journal-title":"Expert. Rev. Respir. Med."},{"key":"10.1016\/j.phrs.2022.106469_bib41","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1096\/fj.201800965R","article-title":"MicroRNA-570 is a novel regulator of cellular senescence and inflammaging","volume":"33","author":"Baker","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.phrs.2022.106469_bib42","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12931-017-0637-3","article-title":"Role and regulation of MKP-1 in airway inflammation","volume":"18","author":"Moosavi","year":"2017","journal-title":"Respir. Res."},{"key":"10.1016\/j.phrs.2022.106469_bib43","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3390\/cancers12040909","article-title":"ERK dephosphorylation through MKP1 deacetylation by SIRT1 attenuates RAS-driven tumorigenesis","volume":"12","author":"Kwon","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.phrs.2022.106469_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117157","article-title":"MAP kinase phosphatase-1, a gatekeeper of the acute innate immune response","volume":"241","author":"Kirk","year":"2020","journal-title":"Life Sci."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822004157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822004157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:45:36Z","timestamp":1760913936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661822004157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":44,"alternative-id":["S1043661822004157"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106469","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin II type-2 receptor activation in alveolar macrophages mediates protection against cigarette smoke-induced chronic obstructive pulmonary disease","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106469"}}