{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:10:59Z","timestamp":1791940259234,"version":"4.3.4"},"reference-count":447,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"am","delay-in-days":344,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100011563","name":"AANA","doi-asserted-by":"publisher","award":["2022-G-5"],"award-info":[{"award-number":["2022-G-5"]}],"id":[{"id":"10.13039\/100011563","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014741","name":"AAMN Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014741","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA047700"],"award-info":[{"award-number":["DA047700"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS111767"],"award-info":[{"award-number":["NS111767"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.phrs.2022.106492","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T12:37:57Z","timestamp":1665405477000},"page":"106492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Glutamatergic systems in neuropathic pain and emerging non-opioid therapies"],"prefix":"10.1016","volume":"185","author":[{"given":"Rhea","family":"Temmermand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia C.K.","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2022.106492_bib1","first-page":"2","article-title":"Assessment of pain: types, mechanism and treatment","volume":"no. 1","author":"Swieboda","year":"2013","journal-title":"Ann. Agric. Environ. Med. Spec."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the international classification of diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106492_bib3","unstructured":"D.J. Zelaya C.E., Lucas J.W., Connor, EM, Chronic Pain and High-impact Chronic Pain Among U.S. Adults, 2019, 2020."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib4","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1186\/1471-2458-11-770","article-title":"Pain as a global public health priority","volume":"11","author":"Goldberg","year":"2011","journal-title":"BMC Public Health"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jpain.2018.07.006","article-title":"Prevalence and profile of high-impact chronic pain in the United States","volume":"20","author":"Pitcher","year":"2019","journal-title":"J. Pain."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010364","article-title":"Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies","volume":"6","author":"Fayaz","year":"2016","journal-title":"BMJ Open"},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib7","doi-asserted-by":"crossref","DOI":"10.1177\/0300060519888102","article-title":"Prevalence of common causes of neuropathic pain in Korea: population-based observational study","volume":"48","author":"Bang","year":"2020","journal-title":"J. Int. Med. Res"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ejp.1090","article-title":"Chronic widespread pain prevalence in the general population: A systematic review","volume":"22","author":"Andrews","year":"2018","journal-title":"Eur. J. Pain."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib9","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.15537\/smj.2019.12.24690","article-title":"Prevalence of chronic pain and high-impact chronic pain in Saudi Arabia","volume":"40","author":"Almalki","year":"2019","journal-title":"Saudi Med. J."},{"issue":"6s","key":"10.1016\/j.phrs.2022.106492_bib10","doi-asserted-by":"crossref","first-page":"S294","DOI":"10.1097\/RHU.0000000000001642","article-title":"Chronic Musculoskeletal Pain and Chronic Widespread Pain in Chile: Prevalence Study Performed as Part of the National Health Survey","volume":"27","author":"Dur\u00e1n","year":"2021","journal-title":"J. Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/ejp.1306","article-title":"Prevalence of self-reported chronic pain among adolescents: Evidence from 42 countries and regions","volume":"23","author":"Gobina","year":"2019","journal-title":"Eur. J. Pain."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12939-021-01496-1","article-title":"Chronic pain experience and health inequities during the COVID-19 pandemic in Canada: qualitative findings from the chronic pain & COVID-19 pan-Canadian study","volume":"20","author":"Dassieu","year":"2021","journal-title":"Int J. Equity Health"},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib13","article-title":"Prevalence of chronic pain in developing countries: systematic review and meta-analysis","volume":"4","author":"S\u00e1","year":"2019","journal-title":"Pain. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib14","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jpain.2010.07.004","article-title":"Prevalence and characteristics of chronic pain in the general population of Hong Kong","volume":"12","author":"Wong","year":"2011","journal-title":"J. Pain."},{"key":"10.1016\/j.phrs.2022.106492_bib15","doi-asserted-by":"crossref","first-page":"4643830","DOI":"10.1155\/2017\/4643830","article-title":"Prevalence of Chronic Pain, Treatments, Perception, and Interference on Life Activities: Brazilian Population-Based Survey","volume":"2017","author":"de Souza","year":"2017","journal-title":"Pain. Res Manag"},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib16","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1097\/j.pain.0000000000001844","article-title":"Almost 1 in 5 South African adults have chronic pain: a prevalence study conducted in a large nationally representative sample","volume":"161","author":"Kamerman","year":"2020","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib17","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s12877-021-02432-2","article-title":"Prevalence and characteristics of chronic Pain in the Chinese community-dwelling elderly: a cross-sectional study","volume":"21","author":"Li","year":"2021","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.phrs.2022.106492_bib18","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.sjpain.2017.07.008","article-title":"Omar, Prevalence and characteristics of chronic pain: Experience of Niger","volume":"17","author":"Assadeck","year":"2017","journal-title":"Scand. J. Pain."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib19","doi-asserted-by":"crossref","first-page":"1730550","DOI":"10.1080\/19932820.2020.1730550","article-title":"A survey of chronic pain in China","volume":"15","author":"Yongjun","year":"2020","journal-title":"Libyan J. Med."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib20","first-page":"221","article-title":"Neurobiological and clinical relationship between psychiatric disorders and chronic pain","volume":"22","author":"Bras","year":"2010","journal-title":"Psychiatr. Danub"},{"key":"10.1016\/j.phrs.2022.106492_bib21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.genhosppsych.2019.04.008","article-title":"Iatrogenic opioid use disorder, chronic pain and psychiatric comorbidity: A systematic review","volume":"59","author":"van Rijswijk","year":"2019","journal-title":"Gen. Hosp. Psychiatry"},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib22","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/HRP.0000000000000198","article-title":"Pain and Depression: A Systematic Review","volume":"26","author":"IsHak","year":"2018","journal-title":"Harv. Rev. Psychiatry"},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11920-013-0421-0","article-title":"Pain and depression: an integrative review of neurobiological and psychological factors","volume":"15","author":"Goesling","year":"2013","journal-title":"Curr. Psychiatry Rep."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.semarthrit.2020.10.006","article-title":"The Prevalence of Psychiatric and Chronic Pain Comorbidities in Fibromyalgia: an ACTTION systematic review","volume":"51","author":"Kleykamp","year":"2021","journal-title":"Semin. Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11920-018-0872-4","article-title":"Psychiatry and Pain Management: at the Intersection of Chronic Pain and Mental Health","volume":"20","author":"Goesling","year":"2018","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.phrs.2022.106492_bib26","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.2147\/JPR.S127014","article-title":"The prevalence of probable neuropathic pain in the US: results from a multimodal general-population health survey","volume":"10","author":"DiBonaventura","year":"2017","journal-title":"J. Pain. Res"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib27","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","article-title":"Neuropathic pain in the general population: a systematic review of epidemiological studies","volume":"155","author":"van Hecke","year":"2014","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib28","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1526-4637.2009.00588.x","article-title":"The prevalence of neuropathic pain: clinical evaluation compared with screening tools in a community population","volume":"10","author":"Yawn","year":"2009","journal-title":"Pain. Med"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","article-title":"The IASP classification of chronic pain for ICD-11: chronic neuropathic pain","volume":"160","author":"Scholz","year":"2019","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib30","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jpain.2012.03.009","article-title":"The economic costs of pain in the United States","volume":"13","author":"Gaskin","year":"2012","journal-title":"J. Pain."},{"key":"10.1016\/j.phrs.2022.106492_bib31","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib32","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","article-title":"Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment","volume":"9","author":"Baron","year":"2010","journal-title":"Lancet Neurol."},{"issue":"3 Suppl","key":"10.1016\/j.phrs.2022.106492_bib33","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.4065\/mcp.2009.0649","article-title":"Recommendations for the pharmacological management of neuropathic pain: an overview and literature update","volume":"85","author":"Dworkin","year":"2010","journal-title":"Mayo Clin. Proc."},{"issue":"37","key":"10.1016\/j.phrs.2022.106492_bib34","first-page":"616","article-title":"The Pharmacological Therapy of Chronic Neuropathic Pain","volume":"113","author":"Binder","year":"2016","journal-title":"Dtsch Arztebl Int"},{"issue":"11","key":"10.1016\/j.phrs.2022.106492_bib35","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1001\/archneur.60.11.1524","article-title":"Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations","volume":"60","author":"Dworkin","year":"2003","journal-title":"Arch. Neurol."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib36","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.4065\/79.12.1533","article-title":"Contemporary management of neuropathic pain for the primary care physician","volume":"79","author":"Chen","year":"2004","journal-title":"Mayo Clin. Proc."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib37","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nm.4374","article-title":"Battling the biology of opioid addiction","volume":"23","year":"2017","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib38","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mcna.2015.08.012","article-title":"Multimodal Treatment of Chronic Pain","volume":"100","author":"Dale","year":"2016","journal-title":"Med. Clin. North Am."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib40","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1097\/j.pain.0000000000000333","article-title":"Increasing placebo responses over time in U.S. clinical trials of neuropathic pain","volume":"156","author":"Tuttle","year":"2015","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bja.2017.11.064","article-title":"Disambiguating pharmacological mechanisms from placebo in neuropathic pain using functional neuroimaging","volume":"120","author":"Wanigasekera","year":"2018","journal-title":"Br. J. Anaesth."},{"issue":"12 Suppl 4","key":"10.1016\/j.phrs.2022.106492_bib42","first-page":"S7","article-title":"Placebo response in clinical trials of depression and its implications for research on chronic neuropathic pain","volume":"65","author":"Dworkin","year":"2005","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.phrs.2022.106492_bib43","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1097\/j.pain.0000000000001340","article-title":"Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy","volume":"159","author":"Finnerup","year":"2018","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s40261-014-0259-1","article-title":"An investigation of factors contributing to higher levels of placebo response in clinical trials in neuropathic pain: a systematic review and meta-analysis","volume":"35","author":"Arakawa","year":"2015","journal-title":"Clin. Drug Investig."},{"key":"10.1016\/j.phrs.2022.106492_bib45","article-title":"overdose deaths in the United States,1999\u20132019., NCHS","volume":"394","author":"Hedegaard","year":"2020","journal-title":"Data Brief."},{"key":"10.1016\/j.phrs.2022.106492_bib46","unstructured":"R.L. Ahmad F.B., Sutton P, Provisional drug overdose death counts, National Center for Health Statistics (2021)."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib47","first-page":"Cd007938","article-title":"Gabapentin for chronic neuropathic pain in adults","volume":"6","author":"Wiffen","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2014","key":"10.1016\/j.phrs.2022.106492_bib48","first-page":"Cd007938","article-title":"Gabapentin for chronic neuropathic pain and fibromyalgia in adults","volume":"4","author":"Moore","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"issue":"9","key":"10.1016\/j.phrs.2022.106492_bib49","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1468-1331.2010.02999.x","article-title":"EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision","volume":"17","author":"Attal","year":"2010","journal-title":"Eur. J. Neurol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib50","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pain.2010.07.031","article-title":"NeuPSIG guidelines on neuropathic pain assessment","volume":"152","author":"Haanp\u00e4\u00e4","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106492_bib51","unstructured":"N. Centre for Clinical Practice at, National Institute for Health and Care Excellence: Clinical Guidelines, Neuropathic Pain: The Pharmacological Management of Neuropathic Pain in Adults in Non-specialist Settings, National Institute for Health and Care Excellence, (UK) Copyright \u00a9 2013, National Institute for Health and Care Excellence, London, 2013."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib52","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1155\/2014\/754693","article-title":"Pharmacological management of chronic neuropathic pain: revised consensus statement from the Canadian Pain Society","volume":"19","author":"Moulin","year":"2014","journal-title":"Pain. Res Manag"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib53","first-page":"107","article-title":"Update on neuropathic pain treatment for trigeminal neuralgia","volume":"20","author":"Al-Quliti","year":"2015","journal-title":"Pharmacol. Surg. Options, Neurosci. (Riyadh"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib54","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic Pain: From Mechanisms to Treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2022.106492_bib55","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1093\/pm\/pnz075","article-title":"A Comprehensive Algorithm for Management of Neuropathic Pain","volume":"20","author":"Bates","year":"2019","journal-title":"Pain. Med"},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2022.106492_bib56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40122-017-0087-0","article-title":"A review of Neuropathic Pain: From Guidelines to Clinical Practice","volume":"6","author":"Cruccu","year":"2017","journal-title":"Pain. Ther."},{"issue":"2015","key":"10.1016\/j.phrs.2022.106492_bib57","first-page":"Cd010902","article-title":"Oral nonsteroidal anti-inflammatory drugs for neuropathic pain","volume":"10","author":"Moore","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib58","first-page":"Cd012227","article-title":"Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults","volume":"12","author":"Wiffen","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib59","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/AJP.0000000000000310","article-title":"Anticonvulsants or Antidepressants in Combination Pharmacotherapy for Treatment of Neuropathic Pain in Cancer Patients: A Systematic Review and Meta-analysis","volume":"32","author":"Guan","year":"2016","journal-title":"Clin. J. Pain."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib60","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1016\/j.pain.2014.09.003","article-title":"The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial","volume":"155","author":"Boyle","year":"2014","journal-title":"Pain"},{"issue":"2012","key":"10.1016\/j.phrs.2022.106492_bib61","first-page":"Cd008943","article-title":"Combination pharmacotherapy for the treatment of neuropathic pain in adults","volume":"7","author":"Chaparro","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"issue":"13","key":"10.1016\/j.phrs.2022.106492_bib62","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1001\/jama.2013.2813","article-title":"Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial","volume":"309","author":"Smith","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2022.106492_bib63","first-page":"Cd007115","article-title":"Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia","volume":"1","author":"Lunn","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib64","first-page":"1999","article-title":"Treatment of Neuropathic Pain with Venlafaxine: A Systematic Review","volume":"18","author":"Aiyer","year":"2017","journal-title":"Pain. Med"},{"key":"10.1016\/j.phrs.2022.106492_bib65","doi-asserted-by":"crossref","first-page":"m4825","DOI":"10.1136\/bmj.m4825","article-title":"Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis","volume":"372","author":"Ferreira","year":"2021","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib66","first-page":"Cd010292","article-title":"Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia","volume":"2","author":"Welsch","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib67","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000447034","article-title":"The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature","volume":"85","author":"Carvalho","year":"2016","journal-title":"Psychother. Psychosom."},{"issue":"2015","key":"10.1016\/j.phrs.2022.106492_bib68","first-page":"Cd011091","article-title":"Venlafaxine for neuropathic pain in adults","volume":"8","author":"Gallagher","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib69","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00280-018-3664-y","article-title":"Comparative study of the effects of venlafaxine and duloxetine on chemotherapy-induced peripheral neuropathy","volume":"82","author":"Farshchian","year":"2018","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"2015","key":"10.1016\/j.phrs.2022.106492_bib70","first-page":"Cd011789","article-title":"Milnacipran for neuropathic pain in adults","volume":"7","author":"Derry","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2015","key":"10.1016\/j.phrs.2022.106492_bib71","first-page":"Cd008244","article-title":"Milnacipran for pain in fibromyalgia in adults","volume":"10","author":"Cording","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib72","first-page":"Cd008244","article-title":"Milnacipran for neuropathic pain and fibromyalgia in adults","volume":"3","author":"Derry","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.phrs.2022.106492_bib73","first-page":"Cd003726","article-title":"Tramadol for neuropathic pain","volume":"3","author":"Hollingshead","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib74","first-page":"Cd003726","article-title":"Tramadol for neuropathic pain in adults","volume":"6","author":"Duehmke","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib75","first-page":"395","article-title":"Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review","volume":"18","author":"Beakley","year":"2015","journal-title":"Pain. Physician"},{"issue":"11","key":"10.1016\/j.phrs.2022.106492_bib76","doi-asserted-by":"crossref","first-page":"1382.e1","DOI":"10.1016\/j.amjmed.2018.04.025","article-title":"Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures","volume":"131","author":"Hassamal","year":"2018","journal-title":"Am. J. Med"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib77","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s40264-020-01012-4","article-title":"Real-World Data on Nonmedical Use of Tramadol from Patients Evaluated for Substance Abuse Treatment in the NAVIPPRO Addiction Severity Index-Multimedia Version (ASI-MV(\u00ae)) Network","volume":"44","author":"Green","year":"2021","journal-title":"Drug Saf."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib78","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/08897077.2012.735216","article-title":"Topical review on the abuse and misuse potential of tramadol and tilidine in Germany","volume":"34","author":"Radbruch","year":"2013","journal-title":"Subst. Abus."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib79","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1111\/add.15059","article-title":"Tramadol use and public health consequences in Iran: a systematic review and meta-analysis","volume":"115","author":"Rostam-Abadi","year":"2020","journal-title":"Addiction"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib80","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3109\/00952990.2015.1014959","article-title":"Adolescent tramadol use and abuse in Egypt","volume":"41","author":"Bassiony","year":"2015","journal-title":"Am. J. Drug Alcohol Abus."},{"key":"10.1016\/j.phrs.2022.106492_bib81","unstructured":"US Department of Justice, Drug Enforcement Administration, Final Rule: Placement of Tramadol into Schedule IV, 2014. \u3008https:\/\/www.deadiversion.usdoj.gov\/fed_regs\/rules\/2014\/fr0702.htm\u3009. (Accessed April 6, 2022)."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib82","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1213\/ANE.0000000000001683","article-title":"Trends in Tramadol: Pharmacology, Metabolism, and Misuse","volume":"124","author":"Miotto","year":"2017","journal-title":"Anesth. Analg."},{"issue":"2015","key":"10.1016\/j.phrs.2022.106492_bib83","first-page":"Cd008242","article-title":"Amitriptyline for neuropathic pain in adults","volume":"7","author":"Moore","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib84","first-page":"Cd011209","article-title":"Nortriptyline for neuropathic pain in adults","volume":"1","author":"Derry","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2014","key":"10.1016\/j.phrs.2022.106492_bib85","first-page":"Cd011003","article-title":"Desipramine for neuropathic pain in adults","volume":"9","author":"Hearn","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib86","first-page":"377","article-title":"Cardiovascular toxicity and tricyclic antidepressants","volume":"41","author":"Jackson","year":"1987","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib87","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuropharm.2004.09.012","article-title":"Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain","volume":"48","author":"Bomholt","year":"2005","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib88","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1533-2500.2003.03020.x","article-title":"Antidepressant pharmacotherapy: considerations for the pain clinician","volume":"3","author":"Jackson","year":"2003","journal-title":"Pain. Pr."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib89","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.pain.2008.04.012","article-title":"Escitalopram in painful polyneuropathy: a randomized, placebo-controlled, cross-over trial","volume":"139","author":"Otto","year":"2008","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib90","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/AJP.0000000000000547","article-title":"Review of NMDA Receptor Antagonists for Treatment of Neuropathic Pain in Clinical Practice","volume":"34","author":"Aiyer","year":"2018","journal-title":"Clin. J. Pain."},{"key":"10.1016\/j.phrs.2022.106492_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.699731","article-title":"The Calcium Channel \u03b12\u03b41 Subunit: Interactional Targets in Primary Sensory Neurons and Role in Neuropathic Pain","volume":"15","author":"Cui","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"11","key":"10.1016\/j.phrs.2022.106492_bib92","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.apmr.2014.06.010","article-title":"Gabapentinoids are effective in decreasing neuropathic pain and other secondary outcomes after spinal cord injury: a meta-analysis","volume":"95","author":"Mehta","year":"2014","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.phrs.2022.106492_bib93","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.2147\/DDDT.S185995","article-title":"A comparative double-blind randomized study on the effectiveness of Duloxetine and Gabapentin on painful diabetic peripheral polyneuropathy","volume":"13","author":"Majdinasab","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib94","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2165\/11536200-000000000-00000","article-title":"A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin","volume":"49","author":"Bockbrader","year":"2010","journal-title":"Clin. Pharmacokinet."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib95","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2174\/1570159X1201140117162802","article-title":"Pregabalin in neuropathic pain: evidences and possible mechanisms","volume":"12","author":"Verma","year":"2014","journal-title":"Curr. Neuropharmacol."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib96","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/papr.12516","article-title":"Effects of Pregabalin in Patients with Neuropathic Pain Previously Treated with Gabapentin: A Pooled Analysis of Parallel-Group, Randomized, Placebo-controlled Clinical Trials","volume":"17","author":"Markman","year":"2017","journal-title":"Pain. Pr."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib97","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4140\/TCP.n.2019.490","article-title":"Gabapentin: Change is in the Wind","volume":"34","author":"McPherson","year":"2019","journal-title":"Sr Care Pharm."},{"issue":"2011","key":"10.1016\/j.phrs.2022.106492_bib98","first-page":"Cd009183","article-title":"Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults","volume":"10","author":"Gill","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib99","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1046\/j.1471-4159.2001.00349.x","article-title":"Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate","volume":"77","author":"Hassel","year":"2001","journal-title":"J. Neurochem"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib100","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neulet.2011.07.023","article-title":"Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury","volume":"502","author":"Hobo","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib101","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2007.04.018","article-title":"Anti-glutamatergic effect of riluzole: comparison with valproic acid","volume":"147","author":"Kim","year":"2007","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.phrs.2022.106492_bib102","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jpain.2013.07.007","article-title":"Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury","volume":"14","author":"Yoshizumi","year":"2013","journal-title":"J. Pain."},{"issue":"11","key":"10.1016\/j.phrs.2022.106492_bib103","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.mayocp.2018.04.007","article-title":"Amyotrophic Lateral Sclerosis: An Update for 2018","volume":"93","author":"Oskarsson","year":"2018","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.phrs.2022.106492_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.107986","article-title":"Disease-modifying therapies in amyotrophic lateral sclerosis","volume":"167","author":"Chi\u00f2","year":"2020","journal-title":"Neuropharmacology"},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib105","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1111\/j.1460-9568.2008.06211.x","article-title":"Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro","volume":"27","author":"Lamanauskas","year":"2008","journal-title":"Eur. J. Neurosci."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib106","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1212\/WNL.55.7.971","article-title":"Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions","volume":"55","author":"Galer","year":"2000","journal-title":"Neurology"},{"issue":"2 Suppl","key":"10.1016\/j.phrs.2022.106492_bib107","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1097\/00002508-200006001-00013","article-title":"The use of NMDA-receptor antagonists in the treatment of chronic pain","volume":"16","author":"Hewitt","year":"2000","journal-title":"Clin. J. Pain."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib108","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s40263-019-00618-2","article-title":"Expanding Role of NMDA Receptor Antagonists in the Management of Pain","volume":"33","author":"Kreutzwiser","year":"2019","journal-title":"CNS Drugs"},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib109","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/j.1526-4637.2007.00402.x","article-title":"Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study","volume":"9","author":"Kiefer","year":"2008","journal-title":"Pain. Med"},{"issue":"1\u20133","key":"10.1016\/j.phrs.2022.106492_bib110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.pain.2009.08.015","article-title":"Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study","volume":"147","author":"Schwartzman","year":"2009","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib111","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11916-018-0664-x","article-title":"The Effect of Ketamine Infusion in the Treatment of Complex Regional Pain Syndrome: a Systemic Review and Meta-analysis","volume":"22","author":"Zhao","year":"2018","journal-title":"Curr. Pain. Headache Rep."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib112","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/2045125316631267","article-title":"Ketamine enantiomers in the rapid and sustained antidepressant effects","volume":"6","author":"Muller","year":"2016","journal-title":"Ther. Adv. Psychopharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib113","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0924-977X(97)00406-9","article-title":"Side effects from increased doses of carbamazepine on neuropsychological and posturographic parameters of humans","volume":"7","author":"Delcker","year":"1997","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2022.106492_bib114","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1186\/s10194-015-0563-z","article-title":"Comparison of tolerability and adverse symptoms in oxcarbazepine and carbamazepine in the treatment of trigeminal neuralgia and neuralgiform headaches using the Liverpool Adverse Events Profile (AEP)","volume":"16","author":"Besi","year":"2015","journal-title":"J. Headache Pain."},{"key":"10.1016\/j.phrs.2022.106492_bib115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejca.2016.06.025","article-title":"Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer","volume":"65","author":"Haumann","year":"2016","journal-title":"Eur. J. Cancer"},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib116","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1191\/0269216303pm815oa","article-title":"Low-dose methadone has an analgesic effect in neuropathic pain: a double-blind randomized controlled crossover trial","volume":"17","author":"Morley","year":"2003","journal-title":"Palliat. Med."},{"issue":"4 Suppl 1","key":"10.1016\/j.phrs.2022.106492_bib117","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/00325481.2013.1110567111","article-title":"Topical therapies in the management of chronic pain","volume":"125","author":"Stanos","year":"2013","journal-title":"Postgrad. Med"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib118","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s40266-019-00739-9","article-title":"Topical Treatment of Localized Neuropathic Pain in the Elderly","volume":"37","author":"Pickering","year":"2020","journal-title":"Drugs Aging"},{"issue":"2014","key":"10.1016\/j.phrs.2022.106492_bib119","first-page":"Cd010958","article-title":"Topical lidocaine for neuropathic pain in adults","volume":"7","author":"Derry","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib120","first-page":"Cd007393","article-title":"Topical capsaicin (high concentration) for chronic neuropathic pain in adults","volume":"1","author":"Derry","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib121","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2174\/1389200221999201116143701","article-title":"Topical Capsaicin for the Treatment of Neuropathic Pain","volume":"22","author":"Sultana","year":"2021","journal-title":"Curr. Drug Metab."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib122","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12120803","article-title":"Botulinum Toxin in the Treatment of Headache","volume":"12","author":"Becker","year":"2020","journal-title":"Toxins (Basel)"},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib123","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11080459","article-title":"Mechanisms of Botulinum Toxin Type A Action on Pain","volume":"11","author":"Matak","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib124","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2174\/1389201020666191202111534","article-title":"The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities","volume":"21","author":"Xu","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41394-020-00321-1","article-title":"Neuropathic pain in spinal cord injury: topical analgesics as a possible treatment","volume":"6","author":"Crul","year":"2020","journal-title":"Spinal Cord. Ser. Cases"},{"key":"10.1016\/j.phrs.2022.106492_bib126","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuroscience.2011.11.020","article-title":"Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence","volume":"204","author":"Hillard","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2022.106492_bib127","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/bs.apha.2017.05.003","article-title":"Cannabinoids and Pain: Sites and Mechanisms of Action","volume":"80","author":"Starowicz","year":"2017","journal-title":"Adv. Pharm."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib128","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/aas.12851","article-title":"A systematic review of the analgesic efficacy of cannabinoid medications in the management of acute pain","volume":"61","author":"Stevens","year":"2017","journal-title":"Acta Anaesthesiol. Scand."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib129","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/rapm-2020-101340","article-title":"Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis","volume":"45","author":"Abdallah","year":"2020","journal-title":"Reg. Anesth. Pain. Med"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib130","first-page":"Cd012182","article-title":"Cannabis-based medicines for chronic neuropathic pain in adults","volume":"3","author":"M\u00fccke","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib131","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/cpt.1381","article-title":"Positive and Negative Effects of Cannabis and Cannabinoids on Health","volume":"105","author":"Cohen","year":"2019","journal-title":"Clin. Pharm. Ther."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib132","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1111\/ejn.13800","article-title":"Cannabinoid-glutamate interactions and neural oscillations: implications for psychosis","volume":"48","author":"Sherif","year":"2018","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib133","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/03602532.2018.1428343","article-title":"Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin, and glutamate systems","volume":"50","author":"Fantegrossi","year":"2018","journal-title":"Drug Metab. Rev."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib134","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1177\/02698811211001107","article-title":"Cannabidiol modulation of hippocampal glutamate in early psychosis","volume":"35","author":"O'Neill","year":"2021","journal-title":"J. Psychopharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib135","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1113\/expphysiol.2012.069922","article-title":"The glutamatergic system as a target for neuropathic pain relief","volume":"98","author":"Osikowicz","year":"2013","journal-title":"Exp. Physiol."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib136","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/physrev.00025.2008","article-title":"Models and mechanisms of hyperalgesia and allodynia","volume":"89","author":"Sandk\u00fchler","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2022.106492_bib137","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/bs.apha.2015.12.003","article-title":"The Role of Regulatory Transporters in Neuropathic Pain","volume":"75","author":"Yousuf","year":"2016","journal-title":"Adv. Pharm."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib138","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082164","article-title":"General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation","volume":"19","author":"Yam","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib139","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/jnc.13200","article-title":"Current approaches to enhance glutamate transporter function and expression","volume":"134","author":"Fontana","year":"2015","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib140","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00702-014-1180-8","article-title":"Glutamate as a neurotransmitter in the healthy brain","volume":"121","author":"Zhou","year":"2014","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib141","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF02253527","article-title":"Glutamate: its role in learning, memory, and the aging brain","volume":"111","author":"McEntee","year":"1993","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib142","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4103\/1673-5374.266047","article-title":"Glutamate receptors and glutamatergic signalling in the peripheral nerves","volume":"15","author":"Chen","year":"2020","journal-title":"Neural Regen. Res"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib143","doi-asserted-by":"crossref","DOI":"10.3390\/cells8020184","article-title":"Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release","volume":"8","author":"Mahmoud","year":"2019","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib144","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000111288","article-title":"Metabolic trafficking between neurons and astrocytes: the glutamate\/glutamine cycle revisited","volume":"17","author":"Westergaard","year":"1995","journal-title":"Dev. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib145","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.brainresrev.2004.04.004","article-title":"Molecular pharmacology of glutamate transporters, EAATs and VGLUTs","volume":"45","author":"Shigeri","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib146","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neuron.2018.05.018","article-title":"Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert","volume":"98","author":"Reiner","year":"2018","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib147","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10059-013-0113-y","article-title":"NMDA receptor as a newly identified member of the metabotropic glutamate receptor family: clinical implications for neurodegenerative diseases","volume":"36","author":"Chung","year":"2013","journal-title":"Mol. Cells"},{"key":"10.1016\/j.phrs.2022.106492_bib148","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnsyn.2016.00020","article-title":"The Emergence of NMDA Receptor Metabotropic Function: Insights from Imaging","volume":"8","author":"Dore","year":"2016","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.phrs.2022.106492_bib149","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.8366.1","article-title":"Non-ionotropic signaling by the NMDA receptor: controversy and opportunity","volume":"5","author":"Gray","year":"2016","journal-title":"F1000Res"},{"issue":"Pt A","key":"10.1016\/j.phrs.2022.106492_bib150","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neuropharm.2016.08.014","article-title":"Ionotropic glutamate receptors contribute to pain transmission and chronic pain","volume":"112","author":"Zhuo","year":"2017","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib151","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11064-018-2614-8","article-title":"NMDA Receptor Dependent Long-term Potentiation in Chronic Pain","volume":"44","author":"Li","year":"2019","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib152","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuroscience.2004.06.040","article-title":"Peripheral glutamate receptors contribute to mechanical hyperalgesia in a neuropathic pain model of the rat","volume":"128","author":"Jang","year":"2004","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2022.106492_bib153","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pain.2005.02.006","article-title":"Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord","volume":"115","author":"Liaw","year":"2005","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib154","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/1073858402238514","article-title":"Metabotropic glutamate receptors: electrical and chemical signaling properties","volume":"8","author":"Coutinho","year":"2002","journal-title":"Neuroscientist"},{"key":"10.1016\/j.phrs.2022.106492_bib155","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/bs.apha.2015.11.001","article-title":"Modulation of Chronic Pain by Metabotropic Glutamate Receptors","volume":"75","author":"Chiechio","year":"2016","journal-title":"Adv. Pharm."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib156","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/sj.bjp.0706877","article-title":"Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist","volume":"149","author":"El-Kouhen","year":"2006","journal-title":"Br. J. Pharm."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib157","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejphar.2007.09.047","article-title":"Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats","volume":"580","author":"Zhu","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib158","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.neures.2006.12.014","article-title":"Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum","volume":"57","author":"Nakao","year":"2007","journal-title":"Neurosci. Res."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib159","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1124\/jpet.113.211185","article-title":"mGluR5 Antagonist-Induced Psychoactive Properties: MTEP Drug Discrimination, a Pharmacologically Selective Non\u2013NMDA Effect with Apparent Lack of Reinforcing Properties","volume":"349","author":"Swedberg","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2022.106492_bib160","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuropharm.2005.05.008","article-title":"Analgesic effects of the selective group II (mGlu2\/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing","volume":"49","author":"Jones","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2022.106492_bib161","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-7-6","article-title":"mGlu2 Metabotropic Glutamate Receptors Restrain Inflammatory Pain and Mediate the Analgesic Activity of Dual mGlu2\/mGlu3 Receptor Agonists","volume":"7","author":"Zammataro","year":"2011","journal-title":"Mol. Pain."},{"key":"10.1016\/j.phrs.2022.106492_bib162","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2018.00464","article-title":"Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors","volume":"11","author":"Pereira","year":"2019","journal-title":"Front. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib163","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1152\/physrev.00007.2013","article-title":"Mechanisms of glutamate transport","volume":"93","author":"Vandenberg","year":"2013","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib164","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/bj1230211","article-title":"A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain","volume":"123","author":"van den Berg","year":"1971","journal-title":"Biochem. J."},{"issue":"22","key":"10.1016\/j.phrs.2022.106492_bib165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms20225671","article-title":"Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System","volume":"20","author":"Malik","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib166","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0896-6273(88)90162-6","article-title":"Glutamate neurotoxicity and diseases of the nervous system","volume":"1","author":"Choi","year":"1988","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib167","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/jcbfm.1990.115","article-title":"Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats","volume":"10","author":"Nilsson","year":"1990","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib168","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3171\/jns.1998.89.6.0971","article-title":"Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study","volume":"89","author":"Vespa","year":"1998","journal-title":"J. Neurosurg."},{"issue":"4906","key":"10.1016\/j.phrs.2022.106492_bib169","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1126\/science.2567056","article-title":"The role of excitatory amino acids and NMDA receptors in traumatic brain injury","volume":"244","author":"Faden","year":"1989","journal-title":"Science"},{"issue":"1\u20133","key":"10.1016\/j.phrs.2022.106492_bib170","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2012.10.032","article-title":"Excitotoxicity: bridge to various triggers in neurodegenerative disorders","volume":"698","author":"Mehta","year":"2013","journal-title":"Eur. J. Pharm."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib171","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1750-3639.2004.tb00056.x","article-title":"Cell death mechanisms following traumatic brain injury","volume":"14","author":"Raghupathi","year":"2004","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib172","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib173","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.pcad.2017.04.005","article-title":"Neuroprotection in the Treatment of Acute Ischemic Stroke","volume":"59","author":"Patel","year":"2017","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib174","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/aps.2014.1","article-title":"Glutamate transporters in brain ischemia: to modulate or not?","volume":"35","author":"Krzyzanowska","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phrs.2022.106492_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114786","article-title":"Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development","volume":"193","author":"Green","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.phrs.2022.106492_bib176","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s40263-020-00764-y","article-title":"Neurobiology, Functions, and Relevance of Excitatory Amino Acid Transporters (EAATs) to Treatment of Refractory Epilepsy","volume":"34","author":"Zaitsev","year":"2020","journal-title":"CNS Drugs"},{"key":"10.1016\/j.phrs.2022.106492_bib177","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2014.05.003","article-title":"Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn","volume":"1581","author":"Putatunda","year":"2014","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib178","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/TA.0b013e31825133c0","article-title":"The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury","volume":"73","author":"Wei","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib179","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuint.2005.12.001","article-title":"Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury","volume":"48","author":"Yi","year":"2006","journal-title":"Neurochem. Int."},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib180","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1089\/neu.2006.23.1518","article-title":"Decreased expression of glutamate transporters in astrocytes after human traumatic brain injury","volume":"23","author":"van Landeghem","year":"2006","journal-title":"J. Neurotrauma"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib181","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1111\/ejn.12202","article-title":"Decreased expression of GLT-1 in the R6\/2 model of Huntington's disease does not worsen disease progression","volume":"38","author":"Petr","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2022.106492_bib182","doi-asserted-by":"crossref","first-page":"107559","DOI":"10.1016\/j.neuropharm.2019.03.002","article-title":"The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics","volume":"161","author":"Pajarillo","year":"2019","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib183","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/BCJ20160505","article-title":"Astrocytic transporters in Alzheimer's disease","volume":"474","author":"Ugbode","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.phrs.2022.106492_bib184","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3389\/fphar.2019.01510","article-title":"Epigenetic Regulation of Excitatory Amino Acid Transporter 2 in Neurological Disorders","volume":"10","author":"Alam","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2022.106492_bib185","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-3-319-55769-4_11","article-title":"Glutamate Transport System as a Novel Therapeutic Target in Chronic Pain: Molecular Mechanisms and Pharmacology","volume":"16","author":"Gegelashvili","year":"2017","journal-title":"Adv. Neurobiol."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib186","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/jnc.12957","article-title":"High-affinity glutamate transporters in chronic pain: an emerging therapeutic target","volume":"131","author":"Gegelashvili","year":"2014","journal-title":"J. Neurochem"},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib187","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.exer.2007.01.008","article-title":"EAAT1 and D-serine expression are early features of human retinal development","volume":"84","author":"Diaz","year":"2007","journal-title":"Exp. Eye Res."},{"issue":"22","key":"10.1016\/j.phrs.2022.106492_bib188","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1073\/pnas.89.22.10955","article-title":"Structure, expression, and functional analysis of a Na(+)-dependent glutamate\/aspartate transporter from rat brain","volume":"89","author":"Storck","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib189","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.17-01-00001.1997","article-title":"Cellular and regional distribution of the glutamate transporter GLAST in the CNS of rats: nonradioactive in situ hybridization and comparative immunocytochemistry","volume":"17","author":"Schmitt","year":"1997","journal-title":"J. Neurosci."},{"issue":"165","key":"10.1016\/j.phrs.2022.106492_bib190","first-page":"1","article-title":"GABA and Glutamate Transporters in Brain","volume":"4","author":"Zhou","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"6403","key":"10.1016\/j.phrs.2022.106492_bib191","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/360464a0","article-title":"Cloning and expression of a rat brain L-glutamate transporter","volume":"360","author":"Pines","year":"1992","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib192","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1046\/j.1471-4159.2003.01553.x","article-title":"The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings","volume":"84","author":"Suchak","year":"2003","journal-title":"J. Neurochem"},{"key":"10.1016\/j.phrs.2022.106492_bib193","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuint.2016.05.009","article-title":"Neuronal vs glial glutamate uptake: Resolving the conundrum","volume":"98","author":"Danbolt","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phrs.2022.106492_bib194","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuint.2016.04.010","article-title":"GLT-1: The elusive presynaptic glutamate transporter","volume":"98","author":"Rimmele","year":"2016","journal-title":"Neurochem. Int."},{"issue":"44","key":"10.1016\/j.phrs.2022.106492_bib195","doi-asserted-by":"crossref","first-page":"27715","DOI":"10.1074\/jbc.271.44.27715","article-title":"Brain glutamate transporter proteins form homomultimers","volume":"271","author":"Haugeto","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"5319","key":"10.1016\/j.phrs.2022.106492_bib196","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1126\/science.276.5319.1699","article-title":"Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1","volume":"276","author":"Tanaka","year":"1997","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.phrs.2022.106492_bib197","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.1523\/JNEUROSCI.18-21-08751.1998","article-title":"The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain","volume":"18","author":"Lehre","year":"1998","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib198","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1177\/1073858413520347","article-title":"Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis","volume":"20","author":"Scofield","year":"2014","journal-title":"Neuroscientist"},{"issue":"6\u20137","key":"10.1016\/j.phrs.2022.106492_bib199","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuint.2007.03.012","article-title":"The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention","volume":"51","author":"Sheldon","year":"2007","journal-title":"Neurochem. Int"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib200","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/ana.20003","article-title":"Altered expression of the glutamate transporter EAAT2b in neurological disease","volume":"55","author":"Maragakis","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.phrs.2022.106492_bib201","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/sj.mp.4002065","article-title":"EAAT2 regulation and splicing: relevance to psychiatric and neurological disorders","volume":"12","author":"Lauriat","year":"2007","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib202","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/jcp.22609","article-title":"Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics","volume":"226","author":"Kim","year":"2011","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib203","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1158\/1535-7163.MCT-20-0006","article-title":"Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy","volume":"19","author":"Wang","year":"2020","journal-title":"Mol. Cancer Ther."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib204","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/jn.00763.2011","article-title":"Glutamate transporter dysfunction associated with nerve injury-induced pain in mice","volume":"107","author":"Napier","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.phrs.2022.106492_bib205","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neuint.2016.05.007","article-title":"The importance of the excitatory amino acid transporter 3 (EAAT3)","volume":"98","author":"Bjorn-Yoshimoto","year":"2016","journal-title":"Neurochem. Int."},{"issue":"15","key":"10.1016\/j.phrs.2022.106492_bib206","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1093\/hmg\/ddy169","article-title":"Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells","volume":"27","author":"Perkins","year":"2018","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.phrs.2022.106492_bib207","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.visres.2014.07.020","article-title":"Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses","volume":"103","author":"Tse","year":"2014","journal-title":"Vis. Res"},{"key":"10.1016\/j.phrs.2022.106492_bib208","series-title":"Encyclopedia of Basic Epilepsy Research","first-page":"1373","article-title":"TRANSPORTERS | Function of Cell-Surface Glutamate Transporters in the Brain: An Important Role for Development and Preventing Seizures","author":"Aniksztejn","year":"2009"},{"issue":"18","key":"10.1016\/j.phrs.2022.106492_bib209","doi-asserted-by":"crossref","first-page":"8028","DOI":"10.1523\/JNEUROSCI.22-18-08028.2002","article-title":"Distribution of cystine\/glutamate exchange transporter, system x(c)-, in the mouse brain","volume":"22","author":"Sato","year":"2002","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib210","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1471-4159.2006.03921.x","article-title":"Cooperative action of glutamate transporters and cystine\/glutamate antiporter system Xc- protects from oxidative glutamate toxicity","volume":"98","author":"Lewerenz","year":"2006","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib211","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pain.2013.08.030","article-title":"Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain","volume":"155","author":"Ungard","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106492_bib212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1744806918822185","article-title":"xCT knockdown in human breast cancer cells delays onset of cancer-induced bone pain","volume":"15","author":"Ungard","year":"2019","journal-title":"Mol. Pain."},{"key":"10.1016\/j.phrs.2022.106492_bib213","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1744-8069-1-30","article-title":"Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states","volume":"1","author":"Tao","year":"2005","journal-title":"Mol. Pain."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib214","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1124\/mol.53.2.195","article-title":"DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters","volume":"53","author":"Shimamoto","year":"1998","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib215","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1046\/j.1471-4159.2001.00588.x","article-title":"Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)","volume":"79","author":"Shigeri","year":"2001","journal-title":"J. Neurochem"},{"key":"10.1016\/j.phrs.2022.106492_bib216","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejphar.2016.11.008","article-title":"The role of inversely operating glutamate transporter in the paradoxical analgesia produced by glutamate transporter inhibitors","volume":"793","author":"Kim","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2022.106492_bib217","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pnpbp.2014.10.011","article-title":"Blockade of spinal glutamate recycling produces paradoxical antinociception in rats with orofacial inflammatory pain","volume":"57","author":"Yang","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2022.106492_bib218","doi-asserted-by":"crossref","first-page":"i69","DOI":"10.1093\/bja\/aeq323","article-title":"When does acute pain become chronic?","volume":"105","author":"Voscopoulos","year":"2010","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib219","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91164-E","article-title":"Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine","volume":"42","author":"Sugimoto","year":"1990","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib220","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jnr.1062","article-title":"Cell death in the superficial dorsal horn in a model of neuropathic pain","volume":"64","author":"Whiteside","year":"2001","journal-title":"J. Neurosci. Res"},{"issue":"47","key":"10.1016\/j.phrs.2022.106492_bib221","doi-asserted-by":"crossref","first-page":"17028","DOI":"10.1523\/JNEUROSCI.1268-11.2011","article-title":"Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain","volume":"31","author":"Leong","year":"2011","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib222","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1016\/j.pain.2011.06.008","article-title":"Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain","volume":"152","author":"De Felice","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106492_bib223","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-94-017-7537-3_8","article-title":"Pain Modulation and the Transition from Acute to Chronic Pain","volume":"904","author":"Heinricher","year":"2016","journal-title":"Adv. Exp. Med Biol."},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2022.106492_bib224","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.pain.2013.06.022","article-title":"Glia and pain: is chronic pain a gliopathy","volume":"154","author":"Ji","year":"2013","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib225","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/glia.22924","article-title":"Gap junction coupling confers isopotentiality on astrocyte syncytium","volume":"64","author":"Ma","year":"2016","journal-title":"Glia"},{"issue":"11","key":"10.1016\/j.phrs.2022.106492_bib226","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41583-019-0218-1","article-title":"Astrocytes in chronic pain and itch","volume":"20","author":"Ji","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib227","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1523\/JNEUROSCI.4707-08.2009","article-title":"Uniquely hominid features of adult human astrocytes","volume":"29","author":"Oberheim","year":"2009","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib228","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.tins.2006.08.004","article-title":"Astrocytic complexity distinguishes the human brain","volume":"29","author":"Oberheim","year":"2006","journal-title":"Trends Neurosci."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib229","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s11064-015-1605-2","article-title":"GLAST But Not Least--Distribution, Function, Genetics and Epigenetics of L-Glutamate Transport in Brain--Focus on GLAST\/EAAT1","volume":"40","author":"\u0160er\u00fd","year":"2015","journal-title":"Neurochem. Res."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib230","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0896-6273(95)90158-2","article-title":"Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry","volume":"15","author":"Chaudhry","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2022.106492_bib231","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.brainres.2010.10.044","article-title":"Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes","volume":"1368","author":"Liao","year":"2011","journal-title":"Brain Res"},{"issue":"9","key":"10.1016\/j.phrs.2022.106492_bib232","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023059","article-title":"Spinal astrocytic activation is involved in a virally-induced rat model of neuropathic pain","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib233","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060733","article-title":"Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model","volume":"8","author":"Ji","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2022.106492_bib234","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neures.2017.08.009","article-title":"The roles of cortical astrocytes in chronic pain and other brain pathologies","volume":"126","author":"Eto","year":"2018","journal-title":"Neurosci. Res."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib235","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/cns.13123","article-title":"Astrocyte morphology: Diversity, plasticity, and role in neurological diseases","volume":"25","author":"Zhou","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phrs.2022.106492_bib236","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.682056","article-title":"Reactive Astrocytes: Critical Players in the Development of Chronic Pain","volume":"12","author":"Tang","year":"2021","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.phrs.2022.106492_bib237","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32237","article-title":"Neuronal activity determines distinct gliotransmitter release from a single astrocyte","volume":"7","author":"Covelo","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.phrs.2022.106492_bib238","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1744-8069-7-93","article-title":"Gliotransmission modulates baseline mechanical nociception","volume":"7","author":"Foley","year":"2011","journal-title":"Mol. Pain."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib239","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13195-015-0139-9","article-title":"Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains","volume":"7","author":"Walker","year":"2015","journal-title":"Alzheimers Res. Ther."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib240","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib241","article-title":"Spinal microglia contribute to cancer-induced pain through system x(C) (-)-mediated glutamate release","volume":"4","author":"Miladinovic","year":"2019","journal-title":"Pain. Rep."},{"key":"10.1016\/j.phrs.2022.106492_bib242","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.08.016","article-title":"Microglia-neuron interactions in the models of neuropathic pain","volume":"169","author":"Tozaki-Saitoh","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib243","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrn.2018.2","article-title":"Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential","volume":"19","author":"Inoue","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib244","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/jdi.12379","article-title":"Microglia in the spinal cord and neuropathic pain","volume":"7","author":"Tsuda","year":"2016","journal-title":"J. Diabetes Invest."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib245","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0169-328X(00)00022-X","article-title":"Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy","volume":"76","author":"L\u00f3pez-Redondo","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.phrs.2022.106492_bib246","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1744-8069-5-15","article-title":"Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation","volume":"5","author":"Xin","year":"2009","journal-title":"Mol. Pain."},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib247","article-title":"The role of oligodendrocytes in chronic pain: cellular and molecular mechanisms","volume":"70","author":"Malta","year":"2019","journal-title":"J. Physiol. Pharm."},{"issue":"31","key":"10.1016\/j.phrs.2022.106492_bib248","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.2174\/0929867325666180522112441","article-title":"Contribution of Spinal Cord Oligodendrocytes to Neuroinflammatory Diseases and Pain","volume":"26","author":"Borghi","year":"2019","journal-title":"Curr. Med. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib249","first-page":"771","article-title":"Oligodendrocyte precursor cell transplantation promotes functional recovery following contusive spinal cord injury in rats and is associated with altered microRNA expression","volume":"17","author":"Yang","year":"2018","journal-title":"Mol. Med Rep."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib250","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/stem.1258","article-title":"Role of neuregulin-1\/ErbB signaling in stem cell therapy for spinal cord injury-induced chronic neuropathic pain","volume":"31","author":"Tao","year":"2013","journal-title":"Stem Cells"},{"issue":"9","key":"10.1016\/j.phrs.2022.106492_bib251","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/glia.22699","article-title":"Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium\/calmodulin-dependent kinase II\u03b2's actin-binding\/-stabilizing domain","volume":"62","author":"Martinez-Lozada","year":"2014","journal-title":"Glia"},{"issue":"Pt B","key":"10.1016\/j.phrs.2022.106492_bib252","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.neuropharm.2016.06.014","article-title":"Glutamate signalling: A multifaceted modulator of oligodendrocyte lineage cells in health and disease","volume":"110","author":"Spitzer","year":"2016","journal-title":"Neuropharmacology"},{"issue":"24","key":"10.1016\/j.phrs.2022.106492_bib253","doi-asserted-by":"crossref","first-page":"7898","DOI":"10.1523\/JNEUROSCI.6129-08.2009","article-title":"Regulation of glutamate transport in developing rat oligodendrocytes","volume":"29","author":"DeSilva","year":"2009","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib254","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ana.1077","article-title":"Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage","volume":"50","author":"Werner","year":"2001","journal-title":"Ann. Neurol."},{"issue":"9","key":"10.1016\/j.phrs.2022.106492_bib255","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41583-020-0333-z","article-title":"Emerging importance of satellite glia in nervous system function and dysfunction","volume":"21","author":"Hanani","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib256","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1634\/stemcells.2007-0080","article-title":"Isolation and characterization of neural crest progenitors from adult dorsal root ganglia","volume":"25","author":"Li","year":"2007","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib257","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1038\/s41467-020-18642-y","article-title":"Satellite glial cells promote regenerative growth in sensory neurons","volume":"11","author":"Avraham","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phrs.2022.106492_bib258","article-title":"Satellite Glial Cells in Pain Research: A Targeted Viewpoint of Potential and Future Directions","volume":"2","author":"Gazerani","year":"2021","journal-title":"Front Pain. Res (Lausanne)"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib259","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.brainresrev.2004.09.001","article-title":"Satellite glial cells in sensory ganglia: from form to function","volume":"48","author":"Hanani","year":"2005","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib260","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/(SICI)1096-9861(20000605)421:3<385::AID-CNE7>3.0.CO;2-S","article-title":"Distribution of the glutamate transporters GLAST and GLT-1 in rat circumventricular organs, meninges, and dorsal root ganglia","volume":"421","author":"Berger","year":"2000","journal-title":"J. Comp. Neurol."},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib261","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1469-7580.2008.00984.x","article-title":"Expression and distribution of 'high affinity' glutamate transporters GLT1, GLAST, EAAC1 and of GCPII in the rat peripheral nervous system","volume":"213","author":"Carozzi","year":"2008","journal-title":"J. Anat."},{"key":"10.1016\/j.phrs.2022.106492_bib262","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neuroscience.2011.05.065","article-title":"Expression, distribution and glutamate uptake activity of high affinity-excitatory aminoacid transporters in in vitro cultures of embryonic rat dorsal root ganglia","volume":"192","author":"Carozzi","year":"2011","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib263","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068312","article-title":"Evidence for glutamate as a neuroglial transmitter within sensory ganglia","volume":"8","author":"Kung","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2022.106492_bib264","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2014.06.047","article-title":"Glutamate release from satellite glial cells of the murine trigeminal ganglion","volume":"578","author":"Wagner","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2022.106492_bib265","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuroscience.2013.02.031","article-title":"Satellite glia cells in dorsal root ganglia express functional NMDA receptors","volume":"240","author":"Castillo","year":"2013","journal-title":"Neuroscience"},{"issue":"51","key":"10.1016\/j.phrs.2022.106492_bib266","doi-asserted-by":"crossref","first-page":"18363","DOI":"10.1073\/pnas.1420601111","article-title":"Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells","volume":"111","author":"Ferrari","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2022.106492_bib267","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuroscience.2013.10.009","article-title":"Glutamate dysregulation in the trigeminal ganglion: a novel mechanism for peripheral sensitization of the craniofacial region","volume":"256","author":"Laursen","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2022.106492_bib268","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.conb.2017.10.003","article-title":"Unwrapping the unappreciated: recent progress in Remak Schwann cell biology","volume":"47","author":"Harty","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"issue":"6454","key":"10.1016\/j.phrs.2022.106492_bib269","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1126\/science.aax6452","article-title":"Specialized cutaneous Schwann cells initiate pain sensation","volume":"365","author":"Abdo","year":"2019","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib270","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1097\/j.pain.0000000000002169","article-title":"Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia","volume":"162","author":"Rinwa","year":"2021","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib271","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1096\/fj.201601121R","article-title":"Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells","volume":"31","author":"Campana","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.phrs.2022.106492_bib272","doi-asserted-by":"crossref","first-page":"29856","DOI":"10.1038\/srep29856","article-title":"Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation","volume":"6","author":"Saitoh","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib273","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib274","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41583-021-00536-7","article-title":"Innovations and advances in modelling and measuring pain in animals","volume":"23","author":"Sadler","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib275","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3109\/00207454.2014.922559","article-title":"Surgical animal models of neuropathic pain: Pros and Cons","volume":"125","author":"Challa","year":"2015","journal-title":"Int. J. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib276","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1472-8206.2009.00801.x","article-title":"Animal models of neuropathic pain","volume":"25","author":"Jaggi","year":"2011","journal-title":"Fundam. Clin. Pharm."},{"issue":"2\u20133","key":"10.1016\/j.phrs.2022.106492_bib277","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejphar.2004.03.051","article-title":"Pharmacological characterization of the chronic constriction injury model of neuropathic pain","volume":"491","author":"De Vry","year":"2004","journal-title":"Eur. J. Pharm."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib278","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib279","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"Kim","year":"1992","journal-title":"Pain"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2022.106492_bib280","article-title":"Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse","volume":"122","author":"Bourquin","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106492_bib281","first-page":"47","article-title":"Partial sciatic nerve transection","volume":"99","author":"Lindenlaub","year":"2004","journal-title":"Methods Mol. Med"},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib282","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/ejp.1745","article-title":"MiRNA-107 contributes to inflammatory pain by down-regulating GLT-1 expression in rat spinal dorsal horn","volume":"25","author":"Zhang","year":"2021","journal-title":"Eur. J. Pain."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib283","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pbb.2004.10.016","article-title":"Comparison of five different rat models of peripheral nerve injury","volume":"80","author":"Dowdall","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2022.106492_bib284","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-0716-0989-7_17","article-title":"Pain and Activity Measurements","volume":"2221","author":"Molstad","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.phrs.2022.106492_bib285","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","article-title":"Methods Used to Evaluate Pain Behaviors in Rodents","volume":"10","author":"Deuis","year":"2017","journal-title":"Front Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib286","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib287","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1471-4159.1984.tb12722.x","article-title":"Decreased uptake and release of D-aspartate in the guinea pig spinal cord after dorsal root section","volume":"42","author":"Potashner","year":"1984","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib288","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1523\/JNEUROSCI.23-07-02899.2003","article-title":"Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats","volume":"23","author":"Sung","year":"2003","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib289","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.neuroscience.2005.11.061","article-title":"Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation","volume":"138","author":"Weng","year":"2006","journal-title":"Neuroscience"},{"issue":"7021","key":"10.1016\/j.phrs.2022.106492_bib290","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature03180","article-title":"Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression","volume":"433","author":"Rothstein","year":"2005","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib291","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S1740925X07000695","article-title":"Gliosis alters expression and uptake of spinal glial amino acid transporters in a mouse neuropathic pain model","volume":"3","author":"Cavaliere","year":"2007","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.phrs.2022.106492_bib292","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2202-15-35","article-title":"Differential neuropathic pain sensitivity and expression of spinal mediators in Lewis and Fischer 344 rats","volume":"15","author":"Le Coz","year":"2014","journal-title":"BMC Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib293","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"Ho Kim","year":"1992","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib294","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ar.20673","article-title":"Temporal changes of astrocyte activation and glutamate transporter-1 expression in the spinal cord after spinal nerve ligation-induced neuropathic pain","volume":"291","author":"Wang","year":"2008","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.phrs.2022.106492_bib295","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1744-8069-4-65","article-title":"Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats","volume":"4","author":"Maeda","year":"2008","journal-title":"Mol. Pain."},{"key":"10.1016\/j.phrs.2022.106492_bib296","article-title":"Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects","volume":"2011","author":"Lin","year":"2011","journal-title":"Pain. Res Treat."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib297","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/ALN.0000000000000796","article-title":"Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus","volume":"123","author":"Kimura","year":"2015","journal-title":"Anesthesiology"},{"issue":"9","key":"10.1016\/j.phrs.2022.106492_bib298","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1097\/j.pain.0000000000000608","article-title":"Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus","volume":"157","author":"Kimura","year":"2016","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib299","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/WNR.0000000000000558","article-title":"Suberoylanilide hydroxamic acid prevents downregulation of spinal glutamate transporter-1 and attenuates spinal nerve ligation-induced neuropathic pain behavior","volume":"27","author":"Cui","year":"2016","journal-title":"Neuroreport"},{"key":"10.1016\/j.phrs.2022.106492_bib300","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bbi.2020.07.009","article-title":"Astrocytic NDRG2 is critical in the maintenance of neuropathic pain","volume":"89","author":"Cheng","year":"2020","journal-title":"Brain. Behav. Immun."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib301","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury","volume":"43","author":"Seltzer","year":"1990","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib302","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/jn.00763.2011","article-title":"Glutamate transporter dysfunction associated with nerve injury-induced pain in mice","volume":"107","author":"Napier","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.phrs.2022.106492_bib303","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1742-2094-8-33","article-title":"Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1","volume":"8","author":"Berger","year":"2011","journal-title":"J. Neuroinflamm."},{"issue":"4\u20135","key":"10.1016\/j.phrs.2022.106492_bib304","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.brainresbull.2009.09.006","article-title":"Amitriptyline upregulates EAAT1 and EAAT2 in neuropathic pain rats","volume":"81","author":"Mao","year":"2010","journal-title":"Brain Res Bull."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib305","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.nbd.2010.11.012","article-title":"Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor","volume":"41","author":"Cirillo","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib306","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.pain.2012.08.011","article-title":"Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord","volume":"153","author":"Inquimbert","year":"2012","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib307","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biotechadv.2011.05.008","article-title":"BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury","volume":"30","author":"Cirillo","year":"2012","journal-title":"Biotechnol. Adv."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib308","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1007\/s12035-014-8943-y","article-title":"Purinergic Modulation of Spinal Neuroglial Maladaptive Plasticity Following Peripheral Nerve Injury","volume":"52","author":"Cirillo","year":"2015","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib309","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbrc.2018.08.137","article-title":"Norepinephrine-induced downregulation of GLT-1 mRNA in rat astrocytes","volume":"504","author":"Kurita","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib310","doi-asserted-by":"crossref","DOI":"10.3390\/cells11071224","article-title":"Altered Spinal Homeostasis and Maladaptive Plasticity in GFAP Null Mice Following Peripheral Nerve Injury","volume":"11","author":"De Luca","year":"2022","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib311","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1213\/ANE.0b013e31822d39c1","article-title":"Intrathecal ultra-low dose naloxone enhances the antinociceptive effect of morphine by enhancing the reuptake of excitatory amino acids from the synaptic cleft in the spinal cord of partial sciatic nerve-transected rats","volume":"113","author":"Yang","year":"2011","journal-title":"Anesth. Analg."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib312","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00586-013-2990-3","article-title":"A rat model for chronic spinal nerve root compression","volume":"23","author":"Xue","year":"2014","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.phrs.2022.106492_bib313","doi-asserted-by":"crossref","DOI":"10.1177\/17448069211066221","article-title":"Inhibiting spinal secretory phospholipase A2 after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling","volume":"17","author":"Kartha","year":"2021","journal-title":"Mol. Pain."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib314","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1002\/glia.21241","article-title":"Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury","volume":"59","author":"Lepore","year":"2011","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib315","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/glia.22936","article-title":"GLT1 overexpression reverses established neuropathic pain-related behavior and attenuates chronic dorsal horn neuron activation following cervical spinal cord injury","volume":"64","author":"Falnikar","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.phrs.2022.106492_bib316","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nbd.2015.03.010","article-title":"GLT1 overexpression in SOD1(G93A) mouse cervical spinal cord does not preserve diaphragm function or extend disease","volume":"78","author":"Li","year":"2015","journal-title":"Neurobiol. Dis."},{"issue":"9","key":"10.1016\/j.phrs.2022.106492_bib317","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109099","article-title":"Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury","volume":"9","author":"Watson","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib318","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/jnr.22624","article-title":"Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury","volume":"89","author":"Lepore","year":"2011","journal-title":"J. Neurosci. Res"},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib319","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/ALN.0b013e318205df50","article-title":"Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant","volume":"114","author":"Yaster","year":"2011","journal-title":"Anesthesiology"},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib320","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/nm.1883","article-title":"Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex","volume":"14","author":"Liu","year":"2008","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib321","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ejp.1343","article-title":"Effects of glial glutamate transporter activator in formalin-induced pain behaviour in mice","volume":"23","author":"Alotaibi","year":"2019","journal-title":"Eur. J. Pain."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib322","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.202","article-title":"Models of Inflammation: Carrageenan- or Complete Freund's Adjuvant (CFA)-Induced Edema and Hypersensitivity in the Rat","volume":"1","author":"McCarson","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.phrs.2022.106492_bib323","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918825044","article-title":"Altered glial glutamate transporter expression in descending circuitry and the emergence of pain chronicity","volume":"15","author":"Guo","year":"2019","journal-title":"Mol. Pain."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib324","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.4049\/jimmunol.166.12.7527","article-title":"Minocycline Provides Neuroprotection Against N-Methyl-d-aspartate Neurotoxicity by Inhibiting Microglia","volume":"166","author":"Tikka","year":"2001","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib325","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jpain.2011.12.002","article-title":"Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of Paclitaxel-induced painful neuropathy","volume":"13","author":"Zhang","year":"2012","journal-title":"J. Pain."},{"key":"10.1016\/j.phrs.2022.106492_bib326","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuroscience.2013.09.033","article-title":"Inhibition of glycogen synthase kinase 3beta activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain","volume":"254","author":"Gao","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2022.106492_bib327","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.expneurol.2013.11.018","article-title":"Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain","volume":"252","author":"Weng","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2022.106492_bib328","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbi.2015.06.015","article-title":"Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice","volume":"49","author":"Morioka","year":"2015","journal-title":"Brain. Behav. Immun."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib329","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-08891-1","article-title":"Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug","volume":"7","author":"Yamamoto","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib330","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neulet.2011.12.029","article-title":"The beta-lactam antibiotic, ceftriaxone, inhibits the development of opioid-induced hyperalgesia in mice","volume":"509","author":"Chen","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2022.106492_bib331","doi-asserted-by":"crossref","DOI":"10.1177\/17448069221093016","article-title":"Spinal NLRP3 inflammasome activation mediates IL-1\u03b2 release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 expression in rats","author":"Yuan","year":"2022","journal-title":"Mol. Pain."},{"key":"10.1016\/j.phrs.2022.106492_bib332","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-1-62703-068-7_8","article-title":"Diabetes in Zucker diabetic fatty rat","volume":"933","author":"Shiota","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.phrs.2022.106492_bib333","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2147\/JPR.S118412","article-title":"Involvement of spinal glutamate transporter-1 in the development of mechanical allodynia and hyperalgesia associated with type 2 diabetes","volume":"9","author":"Shi","year":"2016","journal-title":"J. Pain. Res."},{"key":"10.1016\/j.phrs.2022.106492_bib334","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-Induced Diabetic Models in Mice and Rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharm."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib335","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s11064-021-03308-y","article-title":"Clavulanic Acid Attenuating Effect on the Diabetic Neuropathic Pain in Rats","volume":"46","author":"Kolahdouz","year":"2021","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib336","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","article-title":"Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)","volume":"164","author":"Constantinescu","year":"2011","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.phrs.2022.106492_bib337","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.expneurol.2012.12.012","article-title":"Changes in nociceptive sensitivity and object recognition in experimental autoimmune encephalomyelitis (EAE)","volume":"241","author":"Olechowski","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phrs.2022.106492_bib338","article-title":"Neufeld, Animal models of visceral pain and the role of the microbiome, Neurobiol","volume":"10","author":"West","year":"2021","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106492_bib339","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109030","article-title":"Sex differences in pain along the neuraxis","volume":"210","author":"Presto","year":"2022","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms20051196","article-title":"Sex Differences in a Rodent Model of HIV-1-Associated Neuropathic Pain","volume":"20","author":"Guindon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib341","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/0023677215575863","article-title":"Gender differences in a mouse model of chemotherapy-induced neuropathic pain","volume":"50","author":"Naji-Esfahani","year":"2016","journal-title":"Lab. Anim."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib342","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.physbeh.2005.12.005","article-title":"Effects of sex, hindpaw injection site and stimulus modality on nociceptive sensitivity in arthritic rats","volume":"87","author":"Cook","year":"2006","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib343","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2042-6410-5-4","article-title":"Sex differences in a mouse model of multiple sclerosis: neuropathic pain behavior in females but not males and protection from neurological deficits during proestrus","volume":"5","author":"Rahn","year":"2014","journal-title":"Biol. Sex. Differ."},{"key":"10.1016\/j.phrs.2022.106492_bib344","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.2147\/JPR.S139365","article-title":"Sex differences in complex regional pain syndrome type I (CRPS-I) in mice","volume":"10","author":"Tang","year":"2017","journal-title":"J. Pain. Res"},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib345","first-page":"1963","article-title":"Influence of sex differences on the progression of cancer-induced bone pain","volume":"33","author":"Falk","year":"2013","journal-title":"Anticancer Res"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib346","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0091-3057(00)00461-5","article-title":"Gender and the behavioral manifestations of neuropathic pain","volume":"68","author":"Tall","year":"2001","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2022.106492_bib347","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","article-title":"Neuropathic pain: a maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.phrs.2022.106492_bib348","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neubiorev.2021.01.023","article-title":"Glial and neuroimmune cell choreography in sexually dimorphic pain signaling","volume":"125","author":"Midavaine","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6312","key":"10.1016\/j.phrs.2022.106492_bib349","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.aaf8924","article-title":"Pain regulation by non-neuronal cells and inflammation","volume":"354","author":"Ji","year":"2016","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib350","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1213\/ANE.0000000000004033","article-title":"Microglial Modulation as a Target for Chronic Pain: From the Bench to the Bedside and Back","volume":"128","author":"Haight","year":"2019","journal-title":"Anesth. Analg."},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib351","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1523\/JNEUROSCI.1650-20.2020","article-title":"The Neuroimmunology of Chronic Pain: From Rodents to Humans","volume":"41","author":"Grace","year":"2021","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib352","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1017\/S0140525X97221485","article-title":"Sex differences in pain","volume":"20","author":"Berkley","year":"1997","journal-title":"Behav. Brain Sci."},{"key":"10.1016\/j.phrs.2022.106492_bib353","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jns.2018.03.008","article-title":"Sex differences in neuropathic pain intensity in diabetes","volume":"388","author":"Abraham","year":"2018","journal-title":"J. Neurol. Sci."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib354","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1097\/j.pain.0000000000002215","article-title":"Sex differences in neuroimmune and glial mechanisms of pain","volume":"162","author":"Gregus","year":"2021","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib355","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13293-020-00339-y","article-title":"Sex differences in neuro(auto)immunity and chronic sciatic nerve pain","volume":"11","author":"Linher-Melville","year":"2020","journal-title":"Biol. Sex. Differ."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2022.106492_bib356","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/jnr.23831","article-title":"Sex differences in neuroimmunity and pain","volume":"95","author":"Rosen","year":"2017","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib357","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/jnr.23841","article-title":"Sex Differences in Pain","volume":"95","author":"Sorge","year":"2017","journal-title":"J. Neurosci. Res."},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib358","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib359","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pain.2013.10.027","article-title":"Higher pain perception and lack of recovery from neuropathic pain in females: A behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice","volume":"155","author":"Vacca","year":"2014","journal-title":"Pain"},{"issue":"35","key":"10.1016\/j.phrs.2022.106492_bib360","doi-asserted-by":"crossref","first-page":"6848","DOI":"10.1523\/JNEUROSCI.3257-18.2019","article-title":"Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice","volume":"39","author":"Luo","year":"2019","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.phrs.2022.106492_bib361","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.3390\/ijms22094397","article-title":"Sexually Dimorphic Immune and Neuroimmune Changes Following Peripheral Nerve Injury in Mice: Novel Insights for Gender Medicine","volume":"22","author":"Vacca","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2022.106492_bib362","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/753656","article-title":"Microglia and spinal cord synaptic plasticity in persistent pain","volume":"2013","author":"Taves","year":"2013","journal-title":"Neural Plast."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib363","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0929-6646(11)60074-0","article-title":"Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance","volume":"110","author":"Wen","year":"2011","journal-title":"J. Formos. Med. Assoc."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib364","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/glia.10308","article-title":"Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury","volume":"45","author":"Tsuda","year":"2004","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib365","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12264-017-0145-y","article-title":"Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes","volume":"34","author":"Chen","year":"2018","journal-title":"Neurosci. Bull."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib366","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/j.pain.0000000000001470","article-title":"Tumor necrosis factor receptor 1 inhibition is therapeutic for neuropathic pain in males but not in females","volume":"160","author":"Del Rivero","year":"2019","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib367","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13293-016-0086-6","article-title":"Estrous cycle influences excitatory amino acid transport and visceral pain sensitivity in the rat: effects of early-life stress","volume":"7","author":"Moloney","year":"2016","journal-title":"Biol. Sex. Differ."},{"key":"10.1016\/j.phrs.2022.106492_bib368","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.neuroscience.2016.07.036","article-title":"Sex-dependent activity of the spinal excitatory amino acid transporter: Role of estrous cycle","volume":"333","author":"Sajjad","year":"2016","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib369","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s11011-014-9570-z","article-title":"Estradiol attenuates spinal cord injury-related central pain by decreasing glutamate levels in thalamic VPL nucleus in male rats","volume":"29","author":"Naderi","year":"2014","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib370","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13293-021-00364-5","article-title":"Estrogen receptors in pain modulation: cellular signaling","volume":"12","author":"Chen","year":"2021","journal-title":"Biol. Sex. Differ."},{"issue":"7","key":"10.1016\/j.phrs.2022.106492_bib371","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.bbadis.2018.04.006","article-title":"Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation","volume":"1864","author":"Lee","year":"2018","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib372","doi-asserted-by":"crossref","first-page":"18980","DOI":"10.1038\/srep18980","article-title":"17beta-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical and proteomic investigation on sex-related differences in mice","volume":"6","author":"Vacca","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106492_bib373","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jneuroim.2016.01.011","article-title":"Progesterone modulates pro-inflammatory cytokine expression profile after spinal cord injury: Implications for neuropathic pain","volume":"292","author":"Coronel","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.phrs.2022.106492_bib374","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2014.00040","article-title":"Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed?","volume":"8","author":"Nicotra","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib375","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0197-0186(98)00066-7","article-title":"Influence of the oestrous cycle on L-glutamate and L-aspartate transport in rat brain synaptosomes","volume":"34","author":"Mitrovic","year":"1999","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib376","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/bcp.12094","article-title":"Ketamine for chronic pain: risks and benefits","volume":"77","author":"Niesters","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib377","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tips.2015.11.006","article-title":"Drug Repurposing for the Development of Novel Analgesics","volume":"37","author":"Sisignano","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"11","key":"10.1016\/j.phrs.2022.106492_bib378","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1089\/neu.2015.4079","article-title":"Neuroprotective Effects of the Glutamate Transporter Activator (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153) following Traumatic Brain Injury in the Adult Rat","volume":"33","author":"Fontana","year":"2016","journal-title":"J. Neurotrauma"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib379","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1021\/acschemneuro.7b00308","article-title":"Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2","volume":"9","author":"Kortagere","year":"2018","journal-title":"ACS Chem. Neurosci."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib380","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1021\/acschemneuro.9b00061","article-title":"Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model","volume":"10","author":"Falcucci","year":"2019","journal-title":"ACS Chem. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib381","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pain.2009.11.014","article-title":"An anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats","volume":"148","author":"Hu","year":"2010","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib382","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.neuroscience.2010.06.014","article-title":"Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders","volume":"169","author":"Ramos","year":"2010","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib383","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.sjpain.2011.03.003","article-title":"Effects of the excitatory amino acid transporter subtype 2 (EAAT-2) inducer ceftriaxone on different pain modalities in rat","volume":"2","author":"Eljaja","year":"2018","journal-title":"Scand. J. Pain."},{"issue":"9","key":"10.1016\/j.phrs.2022.106492_bib384","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1002\/glia.23452","article-title":"Region-specific deletions of the glutamate transporter GLT1 differentially affect nerve injury-induced neuropathic pain in mice","volume":"66","author":"Zhao","year":"2018","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib385","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s12031-015-0581-y","article-title":"Targeted Overexpression of Astrocytic Endothelin-1 Attenuates Neuropathic Pain by Upregulating Spinal Excitatory Amino Acid Transporter-2","volume":"57","author":"Hung","year":"2015","journal-title":"J. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib386","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jpain.2013.01.774","article-title":"Analgesic effect of a single preoperative dose of the antibiotic ceftriaxone in humans","volume":"14","author":"Macaluso","year":"2013","journal-title":"J. Pain."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib387","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2011.09.032","article-title":"Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking","volume":"504","author":"Kost","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib388","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1601-5215.2012.00656.x","article-title":"Antiallodynia and antihyperalgesia effects of ceftriaxone in treatment of chronic neuropathic pain in rats","volume":"25","author":"Hajhashemi","year":"2013","journal-title":"Acta Neuropsychiatr."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib389","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/ejp.1117","article-title":"The beta-lactam clavulanic acid mediates glutamate transport-sensitive pain relief in a rat model of neuropathic pain","volume":"22","author":"Kristensen","year":"2018","journal-title":"Eur. J. Pain."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib390","doi-asserted-by":"crossref","first-page":"345","DOI":"10.32598\/bcn.10.4.799.2","article-title":"Upregulation of Glutamate Transporter 1 by Clavulanic Acid Administration and Attenuation of Allodynia and Hyperalgesia in Neuropathic Rats","volume":"10","author":"Amin","year":"2019","journal-title":"Basic Clin. Neurosci."},{"key":"10.1016\/j.phrs.2022.106492_bib391","doi-asserted-by":"crossref","first-page":"977","DOI":"10.2147\/JPR.S154661","article-title":"Ceftriaxone and clavulanic acid induce antiallodynia and anti-inflammatory effects in rats using the carrageenan model","volume":"11","author":"Ochoa-Aguilar","year":"2018","journal-title":"J. Pain. Res"},{"key":"10.1016\/j.phrs.2022.106492_bib392","article-title":"Fundamental Mechanisms of the Cell Death Caused by Nitrosative Stress","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib393","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pbb.2011.04.012","article-title":"Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the \u03b2-lactam antibiotic, ceftriaxone, in mice","volume":"99","author":"Gunduz","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"5","key":"10.1016\/j.phrs.2022.106492_bib394","first-page":"315","article-title":"Antinociceptive effect of clavulanic acid and its preventive activity against development of morphine tolerance and dependence in animal models","volume":"9","author":"Hajhashemi","year":"2014","journal-title":"Res. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib395","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00586-013-2675-y","article-title":"Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy","volume":"22","author":"Albert","year":"2013","journal-title":"Eur. Spine J."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib396","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jbspin.2016.08.001","article-title":"Lack of effectiveness of antibiotics in chronic low back pain with Modic 1 changes","volume":"84","author":"Palazzo","year":"2017","journal-title":"Jt. Bone Spine"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib397","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.neuroscience.2010.07.049","article-title":"Minocycline prevents impaired glial glutamate uptake in the spinal sensory synapses of neuropathic rats","volume":"170","author":"Nie","year":"2010","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib398","first-page":"34","article-title":"Minocycline potentiates the anti-hyperalgesic effect of ceftriaxone in CCI-induced neuropathic pain in rats","volume":"10","author":"Amin","year":"2015","journal-title":"Res Pharm. Sci."},{"key":"10.1016\/j.phrs.2022.106492_bib399","first-page":"229","article-title":"Paradoxical effect of minocycline on established neuropathic pain in rat","volume":"16","author":"Zarei","year":"2017","journal-title":"Excli J."},{"key":"10.1016\/j.phrs.2022.106492_bib400","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2147\/JPR.S292824","article-title":"Minocycline for Controlling Neuropathic Pain: A Systematic Narrative Review of Studies in Humans","volume":"14","author":"Shin","year":"2021","journal-title":"J. Pain. Res."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib401","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1172\/JCI66163","article-title":"Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection","volume":"124","author":"Kong","year":"2014","journal-title":"J. Clin. Invest"},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib402","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1021\/acs.jmedchem.7b00383","article-title":"Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators","volume":"60","author":"Chelini","year":"2017","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib403","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.neuroscience.2008.02.055","article-title":"Amitriptyline induces nuclear transcription factor-\u03baB\u2013dependent glutamate transporter upregulation in chronic morphine-infused rats","volume":"153","author":"Tai","year":"2008","journal-title":"Neuroscience"},{"issue":"24","key":"10.1016\/j.phrs.2022.106492_bib404","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells, The","volume":"20","author":"G\u00f6ttlicher","year":"2001","journal-title":"EMBO J."},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib405","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1089\/neu.1996.13.767","article-title":"Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat","volume":"13","author":"McIntosh","year":"1996","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib406","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuint.2011.10.017","article-title":"Riluzole elevates GLT-1 activity and levels in striatal astrocytes","volume":"60","author":"Carbone","year":"2012","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib407","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/neu.2010.1539","article-title":"Antinociceptive effect of riluzole in rats with neuropathic spinal cord injury pain","volume":"28","author":"Hama","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.phrs.2022.106492_bib408","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neulet.2016.02.065","article-title":"Effects of riluzole on P2X7R expression in the spinal cord in rat model of neuropathic pain","volume":"618","author":"Jiang","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib409","doi-asserted-by":"crossref","first-page":"9661","DOI":"10.1038\/s41598-017-08891-1","article-title":"Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug","volume":"7","author":"Yamamoto","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2022.106492_bib410","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuropharm.2018.06.015","article-title":"Small conductance calcium activated potassium (SK) channel dependent and independent effects of riluzole on neuropathic pain-related amygdala activity and behaviors in rats","volume":"138","author":"Thompson","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2022.106492_bib411","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1155\/2012\/643973","article-title":"Electroacupuncture Confers Antinociceptive Effects via Inhibition of Glutamate Transporter Downregulation in Complete Freund's Adjuvant-Injected Rats","volume":"2012","author":"Kim","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.phrs.2022.106492_bib412","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neulet.2016.03.041","article-title":"Electroacupuncture relieves neuropathic pain via upregulation of glutamate transporters in the spinal cord of rats","volume":"620","author":"Zeng","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib413","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3390\/ijms17030357","article-title":"Spinal Glutamate Transporters Are Involved in the Development of Electroacupuncture Tolerance","volume":"17","author":"Cui","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib414","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/ijnp\/pyx050","article-title":"Glutamate Transport: A New Bench to Bedside Mechanism for Treating Drug Abuse","volume":"20","author":"Spencer","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib415","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2174\/1871527314666150529144655","article-title":"Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders","volume":"14","author":"Roberts-Wolfe","year":"2015","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.phrs.2022.106492_bib416","article-title":"Chronic constriction of the sciatic nerve and pain hypersensitivity testing in rats","volume":"61","author":"Austin","year":"2012","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib417","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3959(93)90100-4","article-title":"Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man","volume":"54","author":"Maves","year":"1993","journal-title":"Pain"},{"issue":"9","key":"10.1016\/j.phrs.2022.106492_bib418","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1007\/s11064-019-02850-0","article-title":"Experimental Characterization of the Chronic Constriction Injury-Induced Neuropathic Pain Model in Mice","volume":"44","author":"Gopalsamy","year":"2019","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib419","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neuroscience.2008.02.031","article-title":"Pharmacological characterization and gene expression profiling of an L5\/L6 spinal nerve ligation model for neuropathic pain in mice","volume":"153","author":"Kiso","year":"2008","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib420","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1272\/jnms.71.399","article-title":"[Neuropathic pain intensity depends on the degree of peripheral nerve injury in the rat]","volume":"71","author":"Abuduhadeer","year":"2004","journal-title":"J. Nippon Med Sch."},{"key":"10.1016\/j.phrs.2022.106492_bib421","doi-asserted-by":"crossref","first-page":"6741295","DOI":"10.1155\/2016\/6741295","article-title":"of Surgical Invasions for Spinal Nerve Ligation with or without Paraspinal Muscle Removal in a Rat Neuropathic Pain Model","volume":"2016","author":"Huang","year":"2016","journal-title":"Biomed. Res Int"},{"issue":"1\u20132","key":"10.1016\/j.phrs.2022.106492_bib422","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0304-3959(98)00045-1","article-title":"Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates","volume":"76","author":"Malmberg","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106492_bib423","article-title":"The spared nerve injury (SNI) model of induced mechanical allodynia in mice","volume":"54","author":"Richner","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib424","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1067\/S1526-5900(03)00781-8","article-title":"Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis","volume":"4","author":"Shields","year":"2003","journal-title":"J. Pain."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib425","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-3959(00)00354-7","article-title":"Partial sciatic nerve transection as a model of neuropathic pain: a qualitative and quantitative neuropathological study","volume":"89","author":"Lindenlaub","year":"2000","journal-title":"Pain"},{"issue":"17","key":"10.1016\/j.phrs.2022.106492_bib426","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1097\/01.brs.0000176239.72928.00","article-title":"Transient cervical nerve root compression in the rat induces bilateral forepaw allodynia and spinal glial activation: mechanical factors in painful neck injuries","volume":"30","author":"Hubbard","year":"2005","journal-title":"Spine (Philos. Pa 1976)"},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib427","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1242\/dmm.025833","article-title":"Rat models of spinal cord injury: from pathology to potential therapies","volume":"9","author":"Kjell","year":"2016","journal-title":"Dis. Model Mech."},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib428","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/ilar.48.4.385","article-title":"Rat models of traumatic spinal cord injury to assess motor recovery","volume":"48","author":"Onifer","year":"2007","journal-title":"Ilar J."},{"issue":"1","key":"10.1016\/j.phrs.2022.106492_bib429","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jneumeth.2008.10.015","article-title":"A simple, inexpensive and easily reproducible model of spinal cord injury in mice: morphological and functional assessment","volume":"177","author":"Marques","year":"2009","journal-title":"J. Neurosci. Methods"},{"issue":"4","key":"10.1016\/j.phrs.2022.106492_bib430","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/jmri.22323","article-title":"Neuropathological differences between rats and mice after spinal cord injury","volume":"32","author":"Byrnes","year":"2010","journal-title":"J. Magn. Reson Imaging"},{"key":"10.1016\/j.phrs.2022.106492_bib431","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2017.01.018","article-title":"Formalin injection produces long-lasting hypersensitivity with characteristics of neuropathic pain","volume":"797","author":"Salinas-Abarca","year":"2017","journal-title":"Eur. J. Pharm."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib432","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1460-9568.2004.03514.x","article-title":"Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS","volume":"20","author":"Raghavendra","year":"2004","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib433","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/ilar\/ilt053","article-title":"Rodent models of chemotherapy-induced peripheral neuropathy","volume":"54","author":"H\u00f6ke","year":"2014","journal-title":"Ilar J."},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib434","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/(SICI)1097-4598(199903)22:3<329::AID-MUS5>3.0.CO;2-8","article-title":"Physiological and immunohistochemical characterization of cisplatin-induced neuropathy in mice","volume":"22","author":"Verd\u00fa","year":"1999","journal-title":"Muscle Nerve"},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0221787","article-title":"A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN)","volume":"14","author":"Gadgil","year":"2019","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.phrs.2022.106492_bib436","doi-asserted-by":"crossref","first-page":"8312","DOI":"10.1523\/JNEUROSCI.22-18-08312.2002","article-title":"Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity","volume":"22","author":"Mao","year":"2002","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.phrs.2022.106492_bib437","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jpain.2020.12.008","article-title":"Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice","volume":"22","author":"Sasaki","year":"2021","journal-title":"J. Pain."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2022.106492_bib438","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0169-328X(00)00260-6","article-title":"A murine model of opioid-induced hyperalgesia","volume":"86","author":"Li","year":"2001","journal-title":"Brain Res Mol. Brain Res"},{"issue":"8","key":"10.1016\/j.phrs.2022.106492_bib439","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/cns.12244","article-title":"A Novel Role of Spinal Astrocytic Connexin 43: Mediating Morphine Antinociceptive Tolerance by Activation of NMDA Receptors and Inhibition of Glutamate Transporter-1 in Rats","volume":"20","author":"Shen","year":"2014","journal-title":"CNS Neurosci. Ther."},{"issue":"2","key":"10.1016\/j.phrs.2022.106492_bib440","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/j.phrs.2022.106492_bib441","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.2337\/db06-0885","article-title":"The leptin-deficient (ob\/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity","volume":"55","author":"Drel","year":"2006","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib442","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/cpmo.11","article-title":"Peripheral Neuropathy in Mouse Models of Diabetes","volume":"6","author":"Jolivalt","year":"2016","journal-title":"Curr. Protoc. Mouse Biol."},{"issue":"1\u20132","key":"10.1016\/j.phrs.2022.106492_bib443","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pain.2008.11.002","article-title":"Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE)","volume":"141","author":"Olechowski","year":"2009","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib444","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.pain.2004.03.025","article-title":"Hyperalgesia in an animal model of multiple sclerosis","volume":"110","author":"Aicher","year":"2004","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.phrs.2022.106492_bib445","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.pain.2007.07.007","article-title":"Analysis of nociception, sex and peripheral nerve innervation in the TMEV animal model of multiple sclerosis","volume":"136","author":"Lynch","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2022.106492_bib446","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.793745","article-title":"Neuropathic Pain in Multiple Sclerosis and Its Animal Models: Focus on Mechanisms, Knowledge Gaps and Future Directions","volume":"12","author":"Mirabelli","year":"2021","journal-title":"Front Neurol."},{"issue":"10","key":"10.1016\/j.phrs.2022.106492_bib447","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1038\/nprot.2007.392","article-title":"Assessment of colon sensitivity by luminal distension in mice","volume":"2","author":"Christianson","year":"2007","journal-title":"Nat. Protoc."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822004388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822004388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:39:26Z","timestamp":1760913566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661822004388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":447,"alternative-id":["S1043661822004388"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106492","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutamatergic systems in neuropathic pain and emerging non-opioid therapies","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106492","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106492"}}