{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:51:25Z","timestamp":1791849085320,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.phrs.2022.106531","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T12:56:57Z","timestamp":1667480217000},"page":"106531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Therapeutic potential of reserpine in metabolic syndrome: An evidence based study"],"prefix":"10.1016","volume":"186","author":[{"given":"Kanika","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh","family":"Paliwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapnil","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phrs.2022.106531_bib1","first-page":"42","article-title":"Combining other antihypertensive drugs with \u03b2-blockers in hypertension: a focus on safety and tolerability","volume":"30","author":"Richards","year":"2014","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.phrs.2022.106531_bib2","article-title":"Blood pressure\u2010lowering efficacy of reserpine for primary hypertension","volume":"12","author":"Shamon","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.phrs.2022.106531_bib3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0895-7061(96)00508-0","article-title":"Calcium channel blockers for hypertension: dissecting the evidence for adverse effects","volume":"10","author":"Opie","year":"1997","journal-title":"Am. J. Hypertens."},{"issue":"1","key":"10.1016\/j.phrs.2022.106531_bib4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1524-6175.2001.990830.x","article-title":"Choosing initial antihypertensive drug therapy for the uncomplicated hypertensive patient, The","volume":"3","author":"Moore","year":"2001","journal-title":"J. Clin. Hypertens."},{"issue":"8","key":"10.1016\/j.phrs.2022.106531_bib5","first-page":"608","article-title":"No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study","volume":"16","author":"Zhu","year":"2019","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.phrs.2022.106531_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuint.2013.12.003","article-title":"The vesicular monoamine transporter 2: an underexplored pharmacological target","volume":"73","author":"Bernstein","year":"2014","journal-title":"Neurochem. Int."},{"issue":"6\u20137","key":"10.1016\/j.phrs.2022.106531_bib7","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.neuint.2010.02.011","article-title":"Reserpine-induced reduction in norepinephrine transporter function requires catecholamine storage vesicles","volume":"56","author":"Mandela","year":"2010","journal-title":"Neurochem. Int."},{"issue":"6","key":"10.1016\/j.phrs.2022.106531_bib8","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3945\/an.116.012245","article-title":"The role of cytochrome P450 epoxygenases, soluble epoxide hydrolase, and epoxyeicosatrienoic acids in metabolic diseases","volume":"7","author":"Xu","year":"2016","journal-title":"Adv. Nutr."},{"issue":"1","key":"10.1016\/j.phrs.2022.106531_bib9","first-page":"1","article-title":"Dynamic behavior of metabolic syndrome progression: a comprehensive systematic review on recent discoveries","volume":"21","author":"Bagheri","year":"2021","journal-title":"BMC Endocrinol. Disord."},{"key":"10.1016\/j.phrs.2022.106531_bib10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jep.2016.10.008","article-title":"Evaluation of anti-hypertensive activity of Ulmus wallichiana extract and fraction in SHR, DOCA-salt-and L-NAME-induced hypertensive rats","volume":"193","author":"Syed","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phrs.2022.106531_bib11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.biopha.2018.01.107","article-title":"Antihypertensive and antioxidant effects of protocatechuic acid in deoxycorticosterone acetate-salt hypertensive rats","volume":"100","author":"Safaeian","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.phrs.2022.106531_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0014-2999(01)01120-7","article-title":"Effects of \u03b1-lipoic acid on deoxycorticosterone acetate\u2013salt-induced hypertension in rats","volume":"424","author":"Takaoka","year":"2001","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.phrs.2022.106531_bib13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/hr.2009.109","article-title":"Effect of heart rate on the risk of developing metabolic syndrome","volume":"32","author":"Inoue","year":"2009","journal-title":"Hypertens. Res."},{"issue":"1","key":"10.1016\/j.phrs.2022.106531_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-021-00735-4","article-title":"Understanding the role of oxidative stress in the incidence of metabolic syndrome and obstructive sleep apnea","volume":"21","author":"Kargar","year":"2021","journal-title":"BMC Endocr. Disord."},{"issue":"1","key":"10.1016\/j.phrs.2022.106531_bib15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12933-018-0762-4","article-title":"Association between insulin resistance and the development of cardiovascular disease","volume":"17","author":"Ormazabal","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"issue":"11","key":"10.1016\/j.phrs.2022.106531_bib16","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1161\/CIRCRESAHA.119.315896","article-title":"Metabolic inflammation and insulin resistance in obesity","volume":"126","author":"Wu","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.phrs.2022.106531_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7635274","article-title":"Benzbromarone attenuates oxidative stress in angiotensin II-and salt-induced hypertensive model rats","volume":"2018","author":"Muraya","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.phrs.2022.106531_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1747-0285.2011.01286.x","article-title":"Synthesis and pharmacological evaluation of novel arginine analogs as potential inhibitors of acetylcholine\u2010induced relaxation in rat thoracic aortic rings","volume":"79","author":"Jain","year":"2012","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.phrs.2022.106531_bib19","first-page":"694","article-title":"Identification of novel Rho kinase-II inhibitors with vasodilatory activity","volume":"11","author":"Kesar","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.phrs.2022.106531_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-32449-4","article-title":"Discovery of novel soluble epoxide hydrolase inhibitors as potent vasodilators","volume":"8","author":"Tripathi","year":"2018","journal-title":"Sci. Rep."},{"issue":"42751","key":"10.1016\/j.phrs.2022.106531_bib21","article-title":"Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening","volume":"7","author":"Temm","year":"2017","journal-title":"Sci. Rep."},{"issue":"104098","key":"10.1016\/j.phrs.2022.106531_bib22","article-title":"Lycopene-supplemented diet ameliorates metabolic syndrome induced by fructose in rats","volume":"73","author":"Ferreira-Santos","year":"2020","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phrs.2022.106531_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-56538-0","article-title":"High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation","volume":"9","author":"Lasker","year":"2019","journal-title":"Sci. Rep."},{"issue":"104404","key":"10.1016\/j.phrs.2022.106531_bib24","article-title":"Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: a comparison with fenofibrate","volume":"107","author":"Khlifi","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.phrs.2022.106531_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.phrs.2022.106531_bib26","first-page":"2231","article-title":"Superoxide dismutase levels in oral squamous cell carcinoma: a biochemical study","volume":"4","author":"Sadashiva","year":"2014","journal-title":"Asian J. Biochem. Pharm. Res."},{"key":"10.1016\/j.phrs.2022.106531_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.phrs.2022.106531_bib28","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phrs.2022.106531_bib29","article-title":"Inhibition of soluble epoxide hydrolase attenuates high-fat-diet\u2013induced hepatic steatosis by reduced systemic inflammatory status in mice","volume":"7","author":"Liu","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.phrs.2022.106531_bib30","doi-asserted-by":"crossref","unstructured":"K. Verma, S. Jain, S. Paliwal, S. Sharma, A clinical perspective of soluble epoxide hydrolase inhibitors in metabolic and related cardiovascular diseases, Current Molecular Pharmacology (2021a).","DOI":"10.2174\/1874467214666210920104352"},{"key":"10.1016\/j.phrs.2022.106531_bib31","first-page":"747","article-title":"Discovery of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore-based virtual screening","volume":"56","author":"Waltenberger","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phrs.2022.106531_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12986-016-0123-9","article-title":"Animal model of metabolic syndrome: a review","volume":"13","author":"Wong","year":"2016","journal-title":"Nutr. Metab."},{"issue":"3","key":"10.1016\/j.phrs.2022.106531_bib33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1476-5381.1975.tb07370.x","article-title":"Effects of reserpine on the adrenal medulla of the spontaneously hypertensive rat","volume":"53","author":"Slotkin","year":"1975","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.phrs.2022.106531_bib34","first-page":"131","article-title":"Enhancement of blood pressure response to dopamine by angiotensin II","volume":"3","author":"Perez-Olea","year":"1981","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.phrs.2022.106531_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/157016113804547593","article-title":"Soluble epoxide hydrolase inhibitors and cardiovascular diseases","volume":"11","author":"Wang","year":"2013","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2022.106531_bib36","first-page":"305","article-title":"Soluble epoxide hydrolase: a potential target for metabolic diseases","volume":"8","author":"He","year":"2016","journal-title":"J. Diabetol."},{"key":"10.1016\/j.phrs.2022.106531_bib37","first-page":"2175","article-title":"An insight on multicentric signaling of angiotensin ii in cardiovascular system: A recent update","author":"Verma","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"51","key":"10.1016\/j.phrs.2022.106531_bib38","doi-asserted-by":"crossref","first-page":"40504","DOI":"10.1074\/jbc.M008106200","article-title":"Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation","volume":"275","author":"Sinal","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.phrs.2022.106531_bib39","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3109\/13880201003739304","article-title":"Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats","volume":"48","author":"Jadeja","year":"2010","journal-title":"Pharm. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2022.106531_bib40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/jphp.13032","article-title":"Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo\/cytokines","volume":"71","author":"Gomaa","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"issue":"2012 (","key":"10.1016\/j.phrs.2022.106531_bib41","article-title":"Amelioration of obesity, glucose intolerance, and oxidative stress in high-fat diet and low-dose streptozotocin-induced diabetic rats by combination consisting of \u201ccurcumin with piperine and quercetin\u201d","author":"Kaur","year":"2012","journal-title":"Int. Sch. Res. Not."},{"issue":"11","key":"10.1016\/j.phrs.2022.106531_bib42","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.3390\/ani11113187","article-title":"Anti-obesity effects of combined Cornus officinalis and Ribes fasciculatum extract in high-fat diet-induced obese male mice","volume":"11","author":"Park","year":"2021","journal-title":"Animals"},{"issue":"1","key":"10.1016\/j.phrs.2022.106531_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-016-1049-5","article-title":"Effects of phenolic-rich extracts of Clinacanthus nutans on high fat and high cholesterol diet-induced insulin resistance","volume":"16","author":"Sarega","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"issue":"4","key":"10.1016\/j.phrs.2022.106531_bib44","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/01.HYP.35.4.1009","article-title":"Development of hypertension in a rat model of diet-induced obesity","volume":"35","author":"Dobrian","year":"2000","journal-title":"Hypertension"},{"issue":"19","key":"10.1016\/j.phrs.2022.106531_bib45","doi-asserted-by":"crossref","first-page":"7039","DOI":"10.3390\/ijms21197039","article-title":"Soluble epoxide hydrolase inhibition by t-TUCB promotes brown adipogenesis and reduces serum triglycerides in diet-induced obesity","volume":"21","author":"Overby","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.phrs.2022.106531_bib46","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1111\/bph.12066","article-title":"Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline\u2010induced cardiac hypertrophy","volume":"168","author":"Althurwi","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"20","key":"10.1016\/j.phrs.2022.106531_bib47","doi-asserted-by":"crossref","first-page":"14189","DOI":"10.1074\/jbc.M113.458414","article-title":"Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue","volume":"288","author":"Bettaieb","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2022.106531_bib48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pharmthera.2017.06.006","article-title":"Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases","volume":"180","author":"Wagner","year":"2017","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.phrs.2022.106531_bib49","article-title":"Inhibition of soluble epoxide hydrolase attenuates high-fat-diet\u2013induced hepatic steatosis by reduced systemic inflammatory status in mice","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2022.106531_bib50","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3389\/fphar.2019.00731","article-title":"Epoxy-oxylipins and soluble epoxide hydrolase metabolic pathway as targets for NSAID-induced gastroenteropathy and inflammation-associated carcinogenesis","volume":"10","author":"Jones","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2022.106531_bib51","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fphar.2019.00036","article-title":"Role of soluble epoxide hydrolase in metabolism of PUFAs in psychiatric and neurological disorders","volume":"10","author":"Hashimoto","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2022.106531_bib52","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/1753-0407.12358","article-title":"Soluble epoxide hydrolase: A potential target for metabolic diseases","volume":"8","author":"He","year":"2016","journal-title":"J. Diabetes."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822004777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661822004777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:39:28Z","timestamp":1760913568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661822004777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":52,"alternative-id":["S1043661822004777"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106531","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of reserpine in metabolic syndrome: An evidence based study","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2022.106531","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106531"}}